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36 results on '"Shang, Xueliang"'

9. Study on the Coarsening Behavior of Interphase Precipitates and Random Precipitates in Steel Under the High-Temperature Environment of Fire.

Author

Cong, Jinghua, Yang, Yongzhe, Zhu, Haibin, Shang, Xueliang, Wu, Hongyu, Song, Zhendong, Wang, Xuemin, and Xu, Xiangyu

Subjects
ELECTRON microscope techniques, TRANSMISSION electron microscopy, PRECIPITATION (Chemistry), CONCENTRATION gradient, SCANNING electron microscopy
Abstract

In the domain of fire-resistant steels, the characteristics of precipitates significantly influence material properties. This study developed a novel heat treatment protocol to concurrently achieve both interphase precipitation and random precipitation. Samples were subjected to isothermal treatments at various temperatures and durations, while techniques such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed to thoroughly analyze the coarsening behavior of the two types of precipitate and reveal their thermal stability differences. The results show that the growth and coarsening rates of interphase precipitates are substantially lower than random precipitates. Coarsening kinetics analysis reveals that the radius of random precipitates follows a 1/3 power law with time at 600 °C and 650 °C, whereas the radius of interphase precipitates adheres to a 1/6 power law at 600 °C and a 1/5 power law at 650 °C. Furthermore, interphase precipitation demonstrates excellent size uniformity, which hinders the formation of a concentration gradient, thereby reducing the coarsening rate and enhancing thermal stability. After prolonged tempering treatment, interphase precipitation maintains a higher strengthening contribution than random precipitation. This study provides novel insights and theoretical foundations for the design and development of fire-resistant steels. [ABSTRACT FROM AUTHOR]

Published
2025
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28. Identification of four novel mutations in the COL4A5 gene identified in Chinese patients with X-linked Alport syndrome

Author

Zhao, Xuechao, Shang, Xueliang, Chen, Chen, Liu, Lina, Wang, Conghui, Zhao, Ganye, Zhang, Junjun, and Kong, Xiangdong

Subjects
targeted next-generation sequencing, COL4A5, Articles, novel mutations, Alport syndrome
Abstract

Alport syndrome (AS) is an inherited progressive nephropathy caused by mutations in one or two of the type IV collagen novel chains (α3, α4 and α5), which are encoded by COL4A3, COL4A4 and COL4A5, respectively. To date, three genetic forms of AS have been reported, including X-linked AS, autosomal recessive AS, and autosomal dominant AS, and ~80% of patients have X-linked AS caused by mutations in COL4A5. In the present study, four novel and one previously reported COL4A5 mutations were identified using targeted next-generation sequencing in Chinese patients suspected of having AS. The results were confirmed by Sanger sequencing, which revealed two novel missense mutations resulting in the substitution of various glycine residues in a collagenous domain containing Gly-X-Y triplet sequence repeats [c.4198G>C, p.(Gly1400Arg) and c.3428G>T, p.(Gly1143Val)], a previously reported missense mutation [c.3071G>A, p.(Gly1024Glu)], a splice site mutation (c.2146+2T>A) and one frameshift mutation [c.1810delC (p.Thr605Ilefs*13)]. After analyzing the affected family members, it was shown that the identified mutations were associated with severe clinical phenotypes. These results broaden the known spectrum of mutations of the COL4A5 gene associated with AS and may have implications for genetic diagnosis, therapy and genetic counseling of affected families.

Published
2020

29. La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice

Author

Yuan,Lu, Li,Qingzhao, Bai,Disi, Shang,Xueliang, Hu,Fen, Chen,Zhenfei, An,Tianyang, Chen,Yajing, and Zhang,Xiujun

Subjects
International Journal of Nanomedicine
Abstract

Lu Yuan,1 Qingzhao Li,1 Disi Bai,2 Xueliang Shang,2 Fen Hu,3 Zhenfei Chen,4 Tianyang An,5 Yajing Chen,6 Xiujun Zhang1 1College of Public Health; 2College of Psychology; 3College of Life Sciences; 4Environmental Monitoring Center Tang Shan, Tangshan 063210, Hebei, People’s Republic of China; 5College of Ji Tang; 6College of Pharmacy of North China University of Science and Technology, Tangshan 063210, Hebei, People’s Republic of ChinaCorrespondence: Xiujun ZhangNorth China University of Science and Technology, Bohai Avenue 21, Tangshan 063210, Hebei, People’s Republic of ChinaTel +86-315-3726335Fax +86-315-3726341Email xiujunzhang66@126.comDisi BaiCollege of Psychology, North China University of Science and Technology, Bohai Avenue 21, Tangshan 063000, People’s Republic of ChinaEmail baidisi@163.comPurpose: Lanthanum oxide (La2O3) nanoparticles (NPs) have been widely used in catalytic and photoelectric applications, but the reproductive toxicity is still unclear. This study evaluated the reproductive toxicity of two different-sized La2O3 particles in the testes.Materials and Methods: Fifty Kunming mice were randomly divided into five groups. Mice were treated with La2O3 NPs by repeated intragastric administration for 90 days (control, nano-sized with 5, 10, 50 mg/kg BW and micro-sized with 50 mg/kg BW). Mice in the control group were treated with de-ionised water without La2O3 NPs. Sperm parameters, testicular histopathology, TEM assessment, hormone assay and nuclear factor erythroid 2-related factor 2 (Nrf-2) pathway were performed and evaluated.Results: The body weight of mice treated with La2O3 NPs or not had no difference; sperm parameters and histological assessment showed that La2O3 NPs could induce reproductive toxicity in the testicle. Serum testosterone and gonadotropin-releasing hormone (GnRH) in the NH (nano-sizedwith 50mg/kgBW) group were markedly decreased relative to control group, and an increase of luteinizing hormone (LH) in NH group was detected . Additionally, transmission electron microscopy revealed that the ultrastructural abnormalities induced by La2O3 NPs were more severe than La2O3 MPs in the testes. Furthermore, La2O3 NPs treatment inhibited the translocation of nuclear factor erythroid 2-related factor 2 (Nrf-2) from the cytoplasm into the nucleus as well as the expression of downstream genes NAD(P)H quinone oxidoreductase1 (NQO1), hemeoxygenase 1 (HO-1) and (glutathione peroxidase) GSH-Px, thus abrogating Nrf-2-mediated defense mechanisms against oxidative stress.Conclusions: The results of this study demonstrated that La2O3 NPs improved the spermatogenesis defects in mice. La2O3 NPs inhibited Nrf-2/ARE signaling pathway that resulted in apoptosis in the mice testes.Keywords: La2O3 nanoparticles, reproductive toxicity, inflammation, Nrf-2/ARE signaling pathway, apoptosis

Published
2020

33. Hot-deformation characteristics of Al-alloyed δ-ferritic and martensitic dual-phase steel

Author

Xu, Xiangyu, Yan, Zepeng, Niu, Zhenzhen, Shang, Xueliang, Wang, Xuemin, and Shang, Chengjia

Abstract

The hot working behavior of Al-alloyed δ-ferritic/martensitic dual-phase steel was investigated using a Gleeble-3800 thermomechanical simulator and compression tests at deformation temperatures and strain rates ranging from 800 to 1100 °C and 0.1 to 3 s−1, respectively. The shape of the flow stress curve of the experimental steel resembled that of traditional dynamic recovery (DRV) flow stress curves produced by work hardening, ferritic DRV, ferritic dynamic recrystallization (DRX), and austenitic dynamic phase transformation (DPT). Additionally, constitutive equations were established to predict the steady-state stress. The apparent deformation activation energy of the steel was approximately 264.7 kJ/mol. Moreover, the microstructure following deformation was investigated using electron backscatter diffraction. The primary dynamic restoration mechanisms of δ-ferrite comprised DRV and DRX at temperatures below and above 900 °C, respectively. However, with increasing deformation temperature and strain rate, the primary dynamic restoration mechanism of δ-ferrite shifted from continuous DRX (CDRX) to discontinuous DRX (DDRX). Additionally, the processing maps of the steel were established using the dynamic materials model. Further, based on the microstructure results, it was found that the power dissipation efficiency of ferritic CDRX, ferritic DDRX, ferritic DRV, and austenitic DPT gradually decreased. Additionally, only one domain of flow instability was identified, and it was located at 1025–1075 °C/0.6–3 s−1. Thus, to avoid unstable deformation regions, a two-stage design of the optimal process parameters for industrial processing is highly essential.

Published
2021
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34. Low-frequency Transcranial Magnetic Stimulation Ameliorates Anhedonic Behaviors and Regulates the Gut Microbiome in Mice Exposed to Chronic Unpredictable Mild Stress.

Author

Gao L, Zhao X, Wu L, Liu C, Ding R, Wang H, and Shang X

Abstract

Objective: This paper presents a preliminary study on whether low-frequency transcranial magnetic stimulation (LF-TMS) can modulate the gut microbiota in mice with chronic unpredictable mild stress (CUMS)., Methods: Mice received LF-TMS (1 Hz, 20 mT) for 28 consecutive days under chronic unpredictable mild stress (CUMS). The composition of gut microbiota of stool samples were tested., Results: CUMS caused significant changes in gut microbiotas, specifically in community diversity of gut microbiotas ( P < .05). Compared with the stressed group mice, the Chao1 index ( P < .05), Observed species index ( P < .05), Faith's PD index ( P < .05) and Shannon index ( P < .05) of the LF-TMS treatment group were significantly increased. Furthermore, 1 Hz LF-TMS-treatment partially recovered chronic stress induced changes of microbiotas, such as the abundance of Chloroflexi , Actinobacteria ., Conclusion: These results manifested that LF-TMS treatment can improve the anhedonic behaviors caused by CUMS in mice, which are connected with regulating the related intestinal microbial community disturbance, including species diversity, structure of gut microbiota, and species composition., Competing Interests: Declaration of Interests: The authors have no conflict of interest to declare., (2024 authors.)

Published
2024
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35. La 2 O 3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

Author

Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, and Zhang X

Subjects
Animals, Apoptosis drug effects, Gene Expression Regulation drug effects, Hydrogen-Ion Concentration, Inflammation pathology, Lanthanum blood, Male, Mice, Nanoparticles ultrastructure, Oxidative Stress drug effects, Oxides blood, Spermatozoa drug effects, Spermatozoa metabolism, Testis drug effects, Testis metabolism, Testis pathology, Testis ultrastructure, Testosterone biosynthesis, Testosterone metabolism, Antioxidant Response Elements genetics, Lanthanum toxicity, NF-E2-Related Factor 2 metabolism, Nanoparticles toxicity, Oxides toxicity, Reproduction drug effects, Signal Transduction drug effects
Abstract

Purpose: Lanthanum oxide (La 2 O 3 ) nanoparticles (NPs) have been widely used in catalytic and photoelectric applications, but the reproductive toxicity is still unclear. This study evaluated the reproductive toxicity of two different-sized La 2 O 3 particles in the testes., Materials and Methods: Fifty Kunming mice were randomly divided into five groups. Mice were treated with La 2 O 3 NPs by repeated intragastric administration for 90 days (control, nano-sized with 5, 10, 50 mg/kg BW and micro-sized with 50 mg/kg BW). Mice in the control group were treated with de-ionised water without La 2 O 3 NPs. Sperm parameters, testicular histopathology, TEM assessment, hormone assay and nuclear factor erythroid 2-related factor 2 (Nrf-2) pathway were performed and evaluated., Results: The body weight of mice treated with La 2 O 3 NPs or not had no difference; sperm parameters and histological assessment showed that La 2 O 3 NPs could induce reproductive toxicity in the testicle. Serum testosterone and gonadotropin-releasing hormone (GnRH) in the NH (nano-sized with 50 mg/kg BW) group were markedly decreased relative to control group, and an increase of luteinizing hormone (LH) in NH group was detected . Additionally, transmission electron microscopy revealed that the ultrastructural abnormalities induced by La 2 O 3 NPs were more severe than La 2 O 3 MPs in the testes. Furthermore, La 2 O 3 NPs treatment inhibited the translocation of nuclear factor erythroid 2-related factor 2 (Nrf-2) from the cytoplasm into the nucleus as well as the expression of downstream genes NAD(P)H quinone oxidoreductase1 (NQO1), hemeoxygenase 1 (HO-1) and (glutathione peroxidase) GSH-Px, thus abrogating Nrf-2-mediated defense mechanisms against oxidative stress., Conclusions: The results of this study demonstrated that La 2 O 3 NPs improved the spermatogenesis defects in mice. La 2 O 3 NPs inhibited Nrf-2/ARE signaling pathway that resulted in apoptosis in the mice testes., Competing Interests: The authors declared they have no competing interests., (© 2020 Yuan et al.)

Published
2020
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36. [The effects and mechanism of islet amyloid polypeptide on insulin secretion in INS-1 cells stimulated by glibenclamide].

Author

Xiao J, Li X, Zhao X, He B, Shang X, Han L, Wu G, Ding X, and Zhu T

Subjects
Calcium, Glucose, Glyburide, Insulin Secretion, Patch-Clamp Techniques, Sulfonylurea Compounds, Insulin metabolism, Insulin-Secreting Cells metabolism, Islet Amyloid Polypeptide pharmacology, Islets of Langerhans drug effects, Islets of Langerhans metabolism
Abstract

Objective: To observe the effects, and study the mechanism of islet amyloid polypeptide (IAPP) on insulin secretion in INS-1 cells stimulated by glibenclamide., Methods: Whole cell patch clamp technique was employed to study the influences of short exposure to IAPP on electrophysiological characteristics of ATP-sensitive K+ channel (K(ATP) channel) upon sulfonylurea stimulation. Intracellular free calcium changes in this process was observed by laser scanning confocal microscope. Insulin was measured by enzyme-linked immunoassay., Results: (1) Insulin secretion stimulated by 1 micomol/L glibenclamide was significantly decreased from (11.43 +/- 1.22) microg/L to (9.40 +/- 0.87) microg/L and to (7.11 +/- 1.85) microg/L after 1 micromol/L and 10 micromol/L IAPP incubation, respectively. (2) Glibenclamide-stimulated calcium influx was dose dependently inhibited by IAPP from 1 micromol/L to 10 micromol/L, with the AUC of fluorescence intensity-time reduced from 427.78 +/- 2.32 to 380.59 +/- 1.49, and to 246.53 +/- 8.41, respectively. (3) Compared with that in control cells (14.59 +/- 0.69) mV, the half activation voltage of KA, channel in response to glibenclamide was significantly increased to (28.75 +/- 0.77) mV and to (46.95 +/- 1.81) mV in cells pretreated with 1 micromol/L and 10 micromol/L IAPP, implicating an inhibitory effect of IAPP on activation of K(ATP) channel., Conclusion: Short-term exposure to high concentration of IAPP inhibited glibenclamide-induced closure of K(ATP) channels and decreased calcium influx, which may ultimately lead to the reduction of insulin secretion in INS-1 cells

Published
2015

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