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216 results on '"Shang, Xiaofei"'

7. Isolation, biological activity, and synthesis of isoquinoline alkaloids.

Author

Yang, Xiaorong, Miao, Xiaolou, Dai, Lixia, Guo, Xiao, Jenis, Janar, Zhang, Jiyu, and Shang, Xiaofei

Subjects
ISOQUINOLINE synthesis, HETEROCYCLIC compounds, AUTHORSHIP in literature, NATURAL products, RESEARCH personnel, ISOQUINOLINE alkaloids
Abstract

Covering: 2019 to 2023 Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014–2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019–2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Evolution of regional collaborative innovation network by the ‘two-wheel drive' of external proximity and endogenous gravity.

Author

Shen, Neng, Shang, Xiaofei, Guo, Wenna, and Zhang, Guoping

Subjects
*REGIONAL development, *SCIENCE education, *EDUCATIONAL finance, *INVESTMENT education, *GRAVITY
Abstract

Collaborative innovation is the key support for promoting high-quality regional development. Taking Guangdong, Fujian and Zhejiang coastal city clusters as an example, this paper analyzes the evolution mechanism of collaborative innovation network based on the ‘two-wheel drive' perspective of external proximity and endogenous gravity. The results show that the difference of resource control ability among nodes in the network is decreasing, and the inverted ‘V’ structure with Xiamen and Putian as the main apex has evolved into a more robust ‘dual core’ (Fuzhou-Xiamen) radiation-type spatial structure. In addition, the evolution of regional collaborative innovation network is driven by ‘two wheels’. In external proximity, institutional proximity plays the strongest role in promoting, followed by geographical proximity, and the promoting role of technological proximity is gradually weakened. In the endogenous gravity, the influence of investment in science and education is strengthening, while the influence of the administrative level is declining. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Multiplex Profiling of miR-122 for Preclinical and Clinical Evaluation of Drug-Induced Liver Injury by a Full-Scale Platform

Author

Dong, Wuqi, Yan, Weizhen, Xu, Yuechen, Shang, Xiaofei, Wang, Wanrong, Qiu, Jie, Wang, Baoxin, Wang, Hua, Zhang, Zhongping, and Zhao, Tingting

Abstract

Diagnostic and monitoring for drug-induced liver injury (DILI) predominantly rely on serum aminotransferases. However, owing to their widespread expression across multiple organs, a significant challenge emerges from the absence of reliable biomarkers for DILI diagnosis. Herein, we introduce a concept for DILI detection, circumventing the nonspecific elevation and delayed release of aminotransferases and then straightforwardly focusing on the core feature of DILI, abnormal gene expression caused by drug overdose. The developed full-scale platform integrates the properties of spherical nucleic acids with elaborately designed fluorescence in situhybridization sequences, enabling the sensitive and specific profiling of drug-overdosed miR-122 expression alterations across molecular, cellular, organismal, and clinical scales and effectively bypassing the phenotypic features of disease. Furthermore, the diagnostic efficacies of serum and total RNA extracted from both mouse and human blood samples for DILI diagnosis were analyzed using the receiver operating characteristic curve and principal component analysis. We anticipate that this universal platform holds potential in facilitating DILI diagnosis, therapeutic evaluation, and prognosis.

Published
2024
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18. Molecular Engineering Design of Enhanced Donor–Acceptor Therapeutic Reagent for Efficient Image‐Guided Photodynamic Therapy (Adv. Healthcare Mater. 28/2023)

Author

Zhao, Tingting, primary, Xu, Yanli, additional, Liu, Rui, additional, Shang, Xiaofei, additional, Huang, Ciyuan, additional, Dong, Wuqi, additional, Long, Min, additional, Zou, Bingsuo, additional, Wang, Xianwen, additional, Li, Gang, additional, Shen, Yuxian, additional, Liu, Tao, additional, and Tang, Bo, additional

Published
2023
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23. The effect of light-irradiated area on the spin dependent photocurrent in zigzag graphene nanoribbon junctions.

Author

Li, Yuejun, Shang, Xiaofei, Zhou, Yan-Hong, and Zheng, Xiaohong

Abstract

In this work, we study the photogalvanic effect of a zigzag graphene nanoribbon junction with a centro-symmetrical structure which consists of 8 zigzag chains by density functional calculations. Specifically, we focus on the cases where the irradiated region is just part of the central region and located at different positions, with an aim to see how the spin dependent photocurrents will change and whether pure spin current can be obtained. It is found that the magnitude of the spin-dependent photocurrents increases with a gradual increase of the irradiated region and pure spin current is achieved when and only when the entire central region is irradiated. In addition, we studied the additive effect in this device to see that if we divide the central region into two parts, whether the sum of the spin current generated by irradiating the two parts individually is equal to that produced when the entire central region is irradiated. It is found that the sum of the spin currents produced by irradiating the two parts individually is smaller than that obtained by irradiating the whole central region, which means that the rule of "1 + 2 = 3" does not hold and the coupling effect between the two parts is important in photocurrent generation. [ABSTRACT FROM AUTHOR]

Published
2023
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32. The occurrence of antibiotic resistance genes in the microbiota of yak, beef and dairy cattle characterized by a metagenomic approach

Author

Shang Xiaofei, Xuzheng Zhou, Wei Xiaojuan, Weiwei Wang, Jiyu Zhang, Lingyu Wu, Bing Li, and Cheng Fusheng

Subjects
0301 basic medicine, Veterinary medicine, Meat, medicine.drug_class, Animal feed, Antibiotics, Drug resistance, 010501 environmental sciences, Gut flora, Antimicrobial resistance, Integron, 01 natural sciences, Article, Integrons, Feces, 03 medical and health sciences, Antibiotic resistance, Species Specificity, Drug Resistance, Bacterial, Drug Discovery, medicine, Animals, Humans, Soil Microbiology, Dairy cattle, 0105 earth and related environmental sciences, Pharmacology, biology, Microbiota, biology.organism_classification, Animal Feed, Computational biology and bioinformatics, Interspersed Repetitive Sequences, 030104 developmental biology, biology.protein, Cattle, Dairy Products, Metagenomics
Abstract

Drug resistance has been partly driven by the overuse of antimicrobials in agricultural animal feed. Better understanding of antibiotic resistance in bovine gut is needed to assess its potential effects based on metagenomic approach and analysis. In this study, we collected 40 fecal samples to explore drug resistance derived from antibiotic use in the bacterial community by an analysis of the diversities and differences of antibiotic-resistant genes (ARGs) in the gut microbiota from yak, beef, and dairy cattle. Overall, 1688 genes were annotated, including 734 ARG subtypes. The ARGs were related to tetracyclines, quinolones, β-lactam, and aminoglycosides, in accordance with the antibiotics widely used in the clinic for humans or animals. The emergence, prevalence, and differences in resistance genes in the intestines of yaks, beef, and dairy cattle may be caused by the selective pressure of different feeding patterns, where yaks were raised without antibiotics for growth promotion. In addition, the abundance of ARGs in yak was lower than in beef and dairy cattle, whereas the abundance of integron, a kind of mobile genetic elements (MGEs) was higher in yaks than those in beef and dairy cattle. Furthermore, the results of this study could provide the basis for a comprehensive profile of various ARGs among yak, beef, and dairy cattle in future.

Published
2021

38. Short communication: Detection and molecular characterization of methicillin-resistant Staphylococcus aureus isolated from subclinical bovine mastitis cases in China

Author

Feng Yang, Cui Dongan, Hongsheng Li, Xurong Wang, Zuoting Yan, Shang Xiaofei, Wang Ling, Yan Sun, Hang Zhang, and Shidong Zhang

Subjects
Methicillin-Resistant Staphylococcus aureus, China, Tetracycline, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Polymerase Chain Reaction, Microbiology, 03 medical and health sciences, Antibiotic resistance, Genetics, medicine, Animals, Adhesins, Bacterial, Mastitis, Bovine, 030304 developmental biology, 0303 health sciences, Virulence, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, Antimicrobial, 040201 dairy & animal science, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Mastitis, Bacterial adhesin, Penicillin, Staphylococcus aureus, Cattle, Female, Animal Science and Zoology, Gentamicins, Food Science, medicine.drug
Abstract

This study investigated the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) isolated from cases of subclinical bovine mastitis in China, as well as resistance mechanisms and virulence genes encoding adhesins and toxins. We determined antimicrobial susceptibility using the disk diffusion method, and analyzed resistance, adhesin, and toxin genes using PCR. We confirmed MRSA in 73 of 498 (14.7%) Staph. aureus isolates recovered from subclinical mastitic milk samples. All isolates were positive for mecA. The MRSA isolates showed high resistance to penicillin (100.0%), gentamicin (100.0%), and tetracycline (98.6%). All MRSA isolates harbored resistance genes blaZ (penicillin), aacA/aphD (gentamicin), and tetM (alone or in combination with tetK, tetracycline). Moreover, all isolates carried the adhesin genes fnbpA, clfA, clfB, cna, sdrE, and map/eap, and most carried sdrC (98.6%), sdrD (95.9%), bbp (94.5%), and ebpS (80.8%). The toxin genes seh, hla, and hld were present in all isolates, and most isolates carried sea (71.2%), seg (84.9%), sei (82.2%), lukE-lukD (97.3%), and hlg (72.6%). These findings of high-level resistance to antimicrobials commonly used in dairy cattle should lead to calls for antibiogram analysis before antimicrobial therapy. The high frequency of adhesin and toxin genes in MRSA indicates their potential virulence in bovine mastitis in China.

Published
2020

46. Short communication: Antimicrobial resistance and virulence genes of Enterococcus faecalis isolated from subclinical bovine mastitis cases in China

Author

Jianxi Li, Feng Yang, Shang Xiaofei, Zuoting Yan, Hongsheng Li, Xurong Wang, and Shidong Zhang

Subjects
China, Virulence Factors, medicine.drug_class, Tetracycline, Antibiotics, Virulence, Erythromycin, Microbial Sensitivity Tests, Biology, Polymerase Chain Reaction, Enterococcus faecalis, Macrolide Antibiotics, Microbiology, 03 medical and health sciences, Antibiotic resistance, RNA, Ribosomal, 16S, Drug Resistance, Bacterial, Genetics, medicine, Animals, Mastitis, Bovine, 030304 developmental biology, 0303 health sciences, Tetracycline Resistance, 0402 animal and dairy science, 04 agricultural and veterinary sciences, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, medicine.disease, 040201 dairy & animal science, Anti-Bacterial Agents, Mastitis, Cattle, Female, Animal Science and Zoology, Food Science, medicine.drug
Abstract

This study aimed to investigate the antimicrobial resistance and virulence genes of Enterococcus faecalis isolated from subclinical bovine mastitis cases in China. Enterococcus faecalis isolates were identified by 16S rRNA amplification and sequencing. Antimicrobial susceptibility was determined by the disc diffusion method. Antimicrobial resistance and virulence genes were tested by PCR. Overall, E. faecalis was recovered from 81 of 1,787 (4.5%) mastitic milk samples. The isolates showed high resistance against tetracycline (87.7%) and erythromycin (79.0%). The most prevalent resistance genes found in the E. faecalis were tetK (96.3%), tetL (79.0%), and tetM (87.7%) for tetracycline and ermC (97.5%) for erythromycin. Moreover, gelE (70.4%), esp (85.2%), efaA (91.4%) were the most common virulence genes. This is the first report to characterize E. faecalis recovered from subclinical bovine mastitis cases in China.

Published
2019

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