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16 results on '"Shang, Haibao"'

1. Extracellular RIPK3 Acts as a Danger-Associated Molecular Pattern to Exaggerate Cardiac Ischemia/Reperfusion Injury

Author

Zhang, Wenjia, Zhang, Junxia, Wang, Zeyuan, Li, Ting, Changyun, Liu, Kang, Xuya, Cui, Xiaomeng, Yang, Jingli, Qu, Huilin, Duanmu, Jiaxin, Peng, Ying, Wang, Kai, Jin, Li, Xie, Peng, Zheng, Wen, Shang, Haibao, Liu, Yahan, Tian, Zhuang, Liu, Zhenyu, Jin, Ye, Li, Yingjia, Li, Nan, Zhuo, Xiaozhen, Wu, Yue, Shi, Xiaolu, Ma, Runhao, Sun, Yueshen, Zhang, Kai, Fang, Xiangming, Hu, Xiaomin, Dong, Erdan, Zhang, Shuyang, and Zhang, Yan

Published
2024
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6. Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

Author

Wang, Jue, primary, Zheng, Wen, additional, Zheng, Shuquan, additional, Yuan, Ye, additional, Wen, Wei, additional, Cui, Weiyi, additional, Xue, Lifang, additional, Sun, Xueting, additional, Shang, Haibao, additional, Zhang, Hongyan, additional, Xiao, Rui-Ping, additional, Gao, Shan, additional, and Zhang, Xiuqin, additional

Published
2023
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8. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis

Author

Zhang, Ting, Zhang, Yan, Cui, Mingyao, Jin, Li, Wang, Yimei, Lv, Fengxiang, Liu, Yuli, Zheng, Wen, Shang, Haibao, Zhang, Jun, Zhang, Mao, Wu, Hongkun, Guo, Jiaojiao, Zhang, Xiuqin, Hu, Xinli, Cao, Chun-Mei, and Xiao, Rui-Ping

Subjects
Heart diseases -- Physiological aspects, Medical research, Medicine, Experimental, Oxidative stress -- Physiological aspects, Apoptosis -- Research, Necrosis -- Physiological aspects, Biological sciences, Health
Abstract

Regulated necrosis (necroptosis) and apoptosis are crucially involved in severe cardiac pathological conditions, including myocardial infarction, ischemia-reperfusion injury and heart failure. Whereas apoptotic signaling is well defined, the mechanisms that underlie cardiomyocyte necroptosis remain elusive. Here we show that receptor-interacting protein 3 (RIP3) triggers myocardial necroptosis, in addition to apoptosis and inflammation, through activation of [Ca.sup.2+]-calmodulin-dependent protein kinase (CaMKII) rather than through the well-established RIP3 partners RIP1 and MLKL. In mice, RIP3 deficiency or CaMKII inhibition ameliorates myocardial necroptosis and heart failure induced by ischemia-reperfusion or by doxorubicin treatment. RIP3-induced activation of CaMKII, via phosphorylation or oxidation or both, triggers opening of the mitochondrial permeability transition pore and myocardial necroptosis. These findings identify CaMKII as a new RIP3 substrate and delineate a RIP3CaMKII-mPTP myocardial necroptosis pathway, a promising target for the treatment of ischemia- and oxidative stress-induced myocardial damage and heart failure., Cell death is a fundamental process involved in development, aging and demise and has been classified into distinct forms, including necrosis, apoptosis and autophagy (1,2). Whereas apoptosis is understood to [...]

Published
2016
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9. Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth

Author

Zhang, Junxia, primary, Liang, Ruqi, additional, Wang, Kai, additional, Zhang, Wenjia, additional, Zhang, Mao, additional, Jin, Li, additional, Xie, Peng, additional, Zheng, Wen, additional, Shang, Haibao, additional, Hu, Qingmei, additional, Li, Jiayi, additional, Chen, Gengjia, additional, Wu, Fujian, additional, Lan, Feng, additional, Wang, Lipeng, additional, Wang, Shi-Qiang, additional, Li, Yongfeng, additional, Zhang, Yong, additional, Liu, Jinghao, additional, Lv, Fengxiang, additional, Hu, Xinli, additional, Xiao, Rui-Ping, additional, Lei, Xiaoguang, additional, and Zhang, Yan, additional

Published
2022
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12. Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity‐related type 2 diabetes mellitus

Author

Wang, Can, primary, Xiao, Yao, additional, Wang, Jue, additional, Hou, Ning, additional, Cui, Weiyi, additional, Hu, Xiaomin, additional, Zeng, Fanxin, additional, Yuan, Ye, additional, Ma, Dongwei, additional, Sun, Xueting, additional, Zhang, Yan, additional, Zheng, Wen, additional, Liu, Yuli, additional, Shang, Haibao, additional, Chen, Liangyi, additional, Xiao, Rui‐Ping, additional, and Zhang, Xiuqin, additional

Published
2019
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13. Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders

Author

Xiao, Yao, primary, Wang, Can, additional, Chen, Jia-Yu, additional, Lu, Fujian, additional, Wang, Jue, additional, Hou, Ning, additional, Hu, Xiaomin, additional, Zeng, Fanxin, additional, Ma, Dongwei, additional, Sun, Xueting, additional, Ding, Yi, additional, Zhang, Yan, additional, Zheng, Wen, additional, Liu, Yuli, additional, Shang, Haibao, additional, Zhu, Wenzhen, additional, Han, Chensheng, additional, Zhang, Yulin, additional, Ouyang, Kunfu, additional, Chen, Liangyi, additional, Chen, Ju, additional, Xiao, Rui-Ping, additional, Li, Chuan-Yun, additional, and Zhang, Xiuqin, additional

Published
2018
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15. Eplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome

Author

Zhang, Yan, primary, Zheng, Wen, additional, Liu, Yuli, additional, Wang, Jue, additional, Peng, Ying, additional, Shang, Haibao, additional, Hou, Ning, additional, Hu, Xiaomin, additional, Ding, Yi, additional, Xiao, Yao, additional, Wang, Can, additional, Zeng, Fanxin, additional, Mao, Jiaming, additional, Zhang, Jun, additional, Ma, Dongwei, additional, Sun, Xueting, additional, Li, Chuanyun, additional, Xiao, Rui-Ping, additional, and Zhang, Xiuqin, additional

Published
2016
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16. Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys.

Author

Wang J, Zheng W, Zheng S, Yuan Y, Wen W, Cui W, Xue L, Sun X, Shang H, Zhang H, Xiao RP, Gao S, and Zhang X

Abstract

Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia. In the present study, a modified small interfering RNA (siRNA) conjugated with GalNAc ANGsiR10 was characterized by in vivo and in vitro studies for its effect on ANGPTL3 silencing, the reduction of plasma triglycerides (TGs), and cholesterol levels in disease models. The results showed that ANGsiR10 displayed a significant and long-lasting efficacy in reducing blood TG and cholesterol levels in both mice and monkeys. Remarkably, the maximal reductions of plasma TG levels in the hApoC3-Tg mice, a model with high TG levels, and the spontaneous dyslipidemia model of rhesus monkey were 96.3% and 67.7%, respectively, after a single dose of ANGsiR10 , with long-lasting effects up to 15 weeks. The cholesterol levels were also reduced in response to treatment, especially the non-HDL-c level, without altering the ApoA/ApoB ratio. This study showed that ANGsiR10 is effective in treating dyslipidemia and is worth further development., Competing Interests: The present study was partially supported by Suzhou Ribo Life Science Co., Ltd. S.Z., H.Z., and S.G. are employees of Ribo. We have fully disclosed these interests and have developed an approved plan to manage any potential conflicts that may arise from such an arrangement., (© 2022 The Authors.)

Published
2022
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