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Introduction: Diabetes mellitus which is characterized by chronic hyperglycaemia accounts for 1.6 million deaths per year globally. In Sri Lanka, 7.4% of adults are with raised fasting blood glucose. Phyllanthus emblica, some fruit, which is also called by Nelli, Amla or Indian Gooseberry, is traditionally believed to facilitate control of hyperglycaemia. Objectives: To systematically review the glycaemic control effect of Phyllanthus emblica. Methods: PubMed, EMBASE, Cochrane Library, CINAHL and AGRICOLA databases were searched to select relevant studies. Studies were selected in two rounds. Three screening questions consisted of; whether study was a human study with Phyllanthus emblica included as a fruit or an ingredient, outcomes were related to glycaemic control and outcomes being reported quantitatively. Following the review of titles and abstracts, full articles were reviewed with screening questions such as, study design, participants, intervention, and findings of outcome. Two reviewers independently screened articles with the third intervening in resolving the conflicts. Meta-analysis was not performed following the heterogeneity assessments and narrative review of the findings was done. Results: Eighteen studies were selected, having respectively excluding 81, 106 and 22 studies with reference to three screening questions. Six studies were done among healthy individuals and 12 were done among patients with diabetes. The studies were conducted among the age group of 18-75 years. Sample sizes of studies ranged from 10 to 150 participants, with 951 participants in total. In three studies, Phyllanthus emblica was used as a single entity and in 15, it was one component of a combined product. Fifteen selected studies described the mean fasting blood sugar (FBS) levels and 13 of them showed statistically what Phyllanthus emblica or products containing it had on glycaemic control, compared to control group (p

Documented literature includes mixed interpretations of the impact of paternal alcoholism on psychobehavioral well-being of offspring. A systematic review and a meta-analysis would facilitate the accurate establishment of this association. This review was done to evaluate the effects of paternal alcohol use disorder (AUD) or problem drinking (PD) on the psycho-behavioral well-being of the offspring at different stages of their lifecycle. This PROSPERO-registered review (CRD42018114754) was conducted by reviewing literature in MEDLINE, EMBASE and PsycINFO databases. A total of 29 articles out of 18113 were selected for data extraction after three selection rounds. Eleven were included in the meta-analyses for three numerically and one categorically assessed outcomes on internalizing behaviour, externalizing behaviour and anxiety. Heterogeneity, risk of bias and the certainty-of-evidence were assessed. Sensitivity analysis was done. Rev-Man (version 5.3) software and “GRADEproGDT” online applications were used. A narrative review was done with studies and sub-groups not included in the meta-analysis under five identified themes: depression and mood disorders, self-perceived mental health problems and personality, aggression, attention deficit hyperactive disorder and other problems. With meta-analyses, all outcomes demonstrated significant standardized mean differences or odds ratio with higher unfavourable values in the exposed group. 'Low' level GRADE certainty was assigned. In sensitivity analysis, associations of similar directions were observed. Narrative review reflected other negative psycho-behavioral consequences of children associated with paternal alcoholism, falling under the five identified themes. In conclusion, robust findings of the meta-analyses and narrative review suggest that paternal AUD and PD are associated with unfavourable psycho-behavioural consequences among their offspring at many stages of the life cycle.