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10. Peripherally administered desacetyl [alpha]-MSH and [alpha]-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression

Author

Wu, Chia-Shan Jenny, Greenwood, David R., Cooney, Janine M., Jensen, Dwayne J., Tatnell, Michele A., Cooper, Garth J.S., and Mountjoy, Kathleen G.

Subjects
Hypothalamus -- Research, Gel electrophoresis -- Research, Biological sciences
Abstract

Desacetyl [alpha]-MSH predominates over [alpha]-MSH during development, but whether it is biologically active and has a physiological role is unclear. We compared the effects of 0.3 [micro]g*[g-l]*[day.sup.-1] desacetyl [alpha]-MSH with that of 0.3 [micro]g*[g.sup.-1*[day.sup.-1] [alpha]-MSH on postnatal body growth by administering the peptides subcutaneously daily for postnatal days 0-14 and also used a two-dimensional gel electrophoresis gel-based proteomic approach to analyze protein changes in hypothalami, the relay center for body weight and growth regulation, after 14 days of treatment. We found that the growth rate between days 1 and 10 was significantly decreased by desacetyl [alpha]-MSH but not by [alpha]-MSH, but by day 14, a time reported for development of a mature pattern of hypothalamic innervation, both peptides had significantly increased neonatal growth compared with PBS-treated control rats. Desacetyl [alpha]-MSH significantly increased spleen weight, but [alpha]-MSH had no effect. [alpha]-MSH significantly decreased kidney weight, but desacetyl [alpha]-MSH had no effect. Both desacetyl [alpha]-MSH and [alpha]-MSH significantly decreased brain weight. By 14 days, both peptides significantly changed expression of a number of hypothalamic proteins, specifically metabolic enzymes, cytoskeleton, signaling, and stress response proteins. We show that peripherally administered desacetyl [alpha]-MSH is biologically active and induces responses that can differ from those for [alpha]-MSH. In conclusion, desacetyl [alpha]-MSH appears to be an important regulator of neonatal rat growth. melanocortin peptides; [alpha]-melanocyte-stimulating hormone; melano-cortin receptors; proopiomelanocortin; hypothalamus

Published
2006

11. Immune modulation of minimal residual disease in early chronic phase chronic myelogenous leukemia: A randomized trial of frontline high-dose imatinib mesylate with or without pegylated interferon alpha-2b and granulocyte-macrophage colony-stimulating factor

Author

Cortes, Jorge, Quintás-Cardama, Alfonso, Jones, Dan, Ravandi, Farhad, Garcia-Manero, Guillermo, Verstovsek, Srdan, Koller, Charles, Hiteshew, Jody, Shan, Jenny, OʼBrien, Susan, and Kantarjian, Hagop

Published
2011
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19. Multi-Faceted Rasch Measurement and Bias Patterns in EFL Writing Performance Assessment

Author

Ya Chen Chien, Shanmao Frank Chang, Wen Johnny Gou, Tung Hsien He, and Ia Shan Jenny Chen

Subjects
Cross-Cultural Comparison, Observer Variation, Argumentative, Rasch model, Psychometrics, Writing, media_common.quotation_subject, Applied psychology, Taiwan, English as a foreign language, Multilingualism, Faculty, Cross-cultural studies, Literature, Rating scale, Perception, Academic Training, Humans, Students, Psychology, Social psychology, General Psychology, media_common
Abstract

This study applied multi-faceted Rasch measurement to examine rater bias in the assessment of essays written by college students learning English as a foreign language. Four raters who had received different academic training from four distinctive disciplines applied a six-category rating scale to analytically rate essays on an argumentative topic and on a descriptive topic. FACETS, a Rasch computer program, was utilized to pinpoint bias patterns by analyzing the rater-topic, rater-category, and topic-category interactions. Results showed: argumentative essays were rated more severely than were descriptive essays; the linguistics-major rater was the most lenient rater, while the literature-major rater was the severest one; and the category of language use received the severest ratings, whereas content was given the most lenient ratings. The severity hierarchies for raters, essay topics, and rating categories suggested that raters' academic training and their perceptions of the importance of categories were associated with their bias patterns. Implications for rater training are discussed.

Published
2013
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20. Peripherally administered desacetyl α-MSH and α-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression

Author

Michele A. Tatnell, Kathleen G. Mountjoy, Janine M. Cooney, Garth J. S. Cooper, Chia Shan Jenny Wu, David R. Greenwood, and Dwayne J. Jensen

Subjects
endocrine system, medicine.medical_specialty, animal structures, Growth regulation, Physiology, Injections, Subcutaneous, Endocrinology, Diabetes and Metabolism, Hypothalamus, Nerve Tissue Proteins, Spleen, Growth, Biology, Mass Spectrometry, Protein expression, Proopiomelanocortin, Physiology (medical), Internal medicine, medicine, Animals, Cytoskeleton, Gel electrophoresis, integumentary system, Body Weight, Biological activity, Organ Size, Rats, medicine.anatomical_structure, Endocrinology, Animals, Newborn, alpha-MSH, biology.protein, Electrophoresis, Polyacrylamide Gel, hormones, hormone substitutes, and hormone antagonists, Chromatography, Liquid
Abstract

Desacetyl α-MSH predominates over α-MSH during development, but whether it is biologically active and has a physiological role is unclear. We compared the effects of 0.3 μg·g−1·day−1desacetyl α-MSH with that of 0.3 μg·g−1·day−1α-MSH on postnatal body growth by administering the peptides subcutaneously daily for postnatal days 0–14 and also used a two-dimensional gel electrophoresis gel-based proteomic approach to analyze protein changes in hypothalami, the relay center for body weight and growth regulation, after 14 days of treatment. We found that the growth rate between days 1 and 10 was significantly decreased by desacetyl α-MSH but not by α-MSH, but by day 14, a time reported for development of a mature pattern of hypothalamic innervation, both peptides had significantly increased neonatal growth compared with PBS-treated control rats. Desacetyl α-MSH significantly increased spleen weight, but α-MSH had no effect. α-MSH significantly decreased kidney weight, but desacetyl α-MSH had no effect. Both desacetyl α-MSH and α-MSH significantly decreased brain weight. By 14 days, both peptides significantly changed expression of a number of hypothalamic proteins, specifically metabolic enzymes, cytoskeleton, signaling, and stress response proteins. We show that peripherally administered desacetyl α-MSH is biologically active and induces responses that can differ from those for α-MSH. In conclusion, desacetyl α-MSH appears to be an important regulator of neonatal rat growth.

Published
2006
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21. α-MSH and Desacetyl-α-MSH Signaling through Melanocortin Receptors

Author

Jillian Cornish, Kathleen G. Mountjoy, Chia-Shan Jenny Wu, and Karen E. Callon

Subjects
endocrine system, medicine.medical_specialty, animal structures, integumentary system, General Neuroscience, HEK 293 cells, Biology, General Biochemistry, Genetics and Molecular Biology, Melanocortin 3 receptor, Cell biology, Adenylyl cyclase, chemistry.chemical_compound, Endocrinology, History and Philosophy of Science, Melanocortin receptor, chemistry, Internal medicine, medicine, ACTH receptor, Melanocortin, Signal transduction, Receptor, hormones, hormone substitutes, and hormone antagonists
Abstract

The functional significance of N-terminal acetylation of ACTH[1-13]NH(2) is unknown. N-terminal acetylation of ACTH[1-13]NH(2) (known as desacetyl-alpha-MSH) to produce alpha-MSH enhances some activities of ACTH[1-13]NH(2) and virtually eliminates others. To determine whether alpha-MSH and desacetyl-alpha-MSH diverge in their coupling to melanocortin receptors in vitro, we measured the sensitivity of MC1, MC3, MC4, and MC5 receptors stably expressed in HEK293 cells to these peptides, functionally coupling them to adenylyl cyclase and a calcium signaling pathway. alpha-MSH and desacetyl-alpha-MSH similarly coupled these overexpressed receptors to both signaling pathways. In contrast, we discovered that alpha-MSH significantly increased primary rat osteoblast proliferation while for desacetyl-alpha-MSH there was only a trend to do the same. Osteoblast cells expressing very low levels of endogenous melanocortin receptors, in contrast with transfected HEK293 cells overexpressing a single melanocortin receptor, may provide an in vitro model for differentiating between alpha-MSH and desacetyl-alpha-MSH signaling.

Published
2003
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22. alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors

Author

Kathleen G, Mountjoy, Chia-Shan Jenny, Wu, Jillian, Cornish, and Karen E, Callon

Subjects
Osteoblasts, Pro-Opiomelanocortin, Pigmentation, Receptors, Melanocortin, Proteins, Peptide Fragments, Cell Line, Eating, Receptors, Corticotropin, alpha-MSH, Animals, Humans, Intercellular Signaling Peptides and Proteins, Agouti-Related Protein, Calcium, Adenylyl Cyclases, Signal Transduction
Abstract

The functional significance of N-terminal acetylation of ACTH[1-13]NH(2) is unknown. N-terminal acetylation of ACTH[1-13]NH(2) (known as desacetyl-alpha-MSH) to produce alpha-MSH enhances some activities of ACTH[1-13]NH(2) and virtually eliminates others. To determine whether alpha-MSH and desacetyl-alpha-MSH diverge in their coupling to melanocortin receptors in vitro, we measured the sensitivity of MC1, MC3, MC4, and MC5 receptors stably expressed in HEK293 cells to these peptides, functionally coupling them to adenylyl cyclase and a calcium signaling pathway. alpha-MSH and desacetyl-alpha-MSH similarly coupled these overexpressed receptors to both signaling pathways. In contrast, we discovered that alpha-MSH significantly increased primary rat osteoblast proliferation while for desacetyl-alpha-MSH there was only a trend to do the same. Osteoblast cells expressing very low levels of endogenous melanocortin receptors, in contrast with transfected HEK293 cells overexpressing a single melanocortin receptor, may provide an in vitro model for differentiating between alpha-MSH and desacetyl-alpha-MSH signaling.

Published
2003

25. EUTOS Score Is Not Predictive for Survival and Outcome in Patients (pts) with Chronic Myeloid Leukemia in Early Chronic Phase (CML-CP) Treated with Tyrosine Kinase Inhibitors (TKIs) At MD Anderson Cancer Center (MDACC),

Author

Nazha, Aziz, primary, Jabbour, Elias, additional, Cortes, Jorge E., additional, O'Brien, Susan, additional, Shan, Jenny, additional, Garcia-Manero, Guillermo, additional, Quintas-Cardama, Alfonso, additional, and Kantarjian, Hagop M., additional

Published
2011
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26. Improved Survival in Chronic Myeloid Leukemia (CML) Since the Introductin of Imatinib Therapy - A Single Institution Historical Experience

Author

Lee, Hun, primary, Cortes, Jorge E., additional, O'Brien, Susan, additional, Jabbour, Elias, additional, Garcia-Manero, Guillermo, additional, Quintas-Cardama, Alfonso, additional, Shan, Jenny, additional, Rios, Mary Beth, additional, Ravandi, Farhad, additional, Faderl, Stefan, additional, Kadia, Tapan, additional, Borthakur, Gautam, additional, Huang, Xuelin, additional, and Kantarjian, Hagop M., additional

Published
2011
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28. Impact of Treatment End Point Definitions on Perceived Differences in Long-Term Outcome With Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia

Author

Kantarjian, Hagop, primary, O'Brien, Susan, additional, Jabbour, Elias, additional, Shan, Jenny, additional, Ravandi, Farhad, additional, Kadia, Tapan, additional, Faderl, Stefan, additional, Garcia-Manero, Guillermo, additional, Borthakur, Gautam, additional, and Cortes, Jorge, additional

Published
2011
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29. The Achievement of a 3-Month Complete Cytogenetic Response (3-mo CCyR) to Second Generation (2nd) Tyrosine Kinase Inhibitors (TKI) Post Imatinib Failure Is the Only Predictive Factor for Event-Free (EFS) and Overall Survival (OS)

Author

Jabbour, Elias, primary, Kantarjian, Hagop M., additional, Shan, Jenny, additional, O'Brien, Susan, additional, Quintas-Cardama, Alfonso, additional, Garcia-Manero, Guillermo, additional, and Cortes, Jorge, additional

Published
2010
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30. The Achievement of An Early Complete Cytogenetic Response (CCyR) Is A Major Determinant for Outcome In Patients (pts) with Early Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKIs).

Author

Jabbour, Elias, primary, Kantarjian, Hagop M., additional, Shan, Jenny, additional, O'Brien, MD, Susan, additional, Kadia, Tapan, additional, Borthakur, Gautam, additional, Quintas-Cardama, Alfonso, additional, Garcia-Manero, Guillermo, additional, Ravandi, Farhad, additional, and Cortes, Jorge, additional

Published
2010
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31. Incidence of Secondary Neoplasms In Patients with Acute Promyelocytic Leukemia Treated with All-Trans-Retinoic Acid (ATRA) with Chemotherapy or with Arsenic Trioxide (ATO).

Author

Eghtedar, Alireza, primary, Faderl, Stefan, additional, Kantarjian, Hagop, additional, O'Brien, Susan, additional, Garcia-Manero, Guillermo, additional, Ferrajoli, Alessandra, additional, Kadia, Tapan, additional, Pierce, Sherry A., additional, Shan, Jenny, additional, Cortes, Jorge E., additional, and Ravandi, Farhad, additional

Published
2010
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35. Efficacy of Nilotinib in Patients (Pts) with Newly Diagnosed, Previously Untreated Philadelphia Chromosome (Ph)-Positive Chronic Myelogenous Leukemia in Early Chronic Phase (CML-CP).

Author

Cortes, Jorge, primary, O'Brien, Susan, additional, Jones, Dan, additional, Jabbour, Elias, additional, Konopleva, Marina, additional, Ferrajoli, Alessandra, additional, Kadia, Tapan, additional, Borthakur, Gautam, additional, Stigliano, Denise, additional, Shan, Jenny, additional, and Kantarjian, Hagop, additional

Published
2009
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36. Predictive Factors for Response and Outcome in Patients (pts) Treated with Second Generation Tyrosine Kinase Inhibitors (2-TKI) for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Post Imatinib Failure.

Author

Jabbour, Elias, primary, Kantarjian, Hagop, additional, O'Brien, Susan, additional, Shan, Jenny, additional, Garcia-Manero, Guillermo, additional, Wierda, William, additional, Ravandi, Farhad, additional, Borthakur, Gautam, additional, Rios, Mary Beth, additional, and Cortes, Jorge, additional

Published
2009
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38. Hypomethylating Therapy in Patients with AML and High-Risk MDS and Chromosome 5 and 7 Abnormalities Is Associated with An Improved Outcome Compared to Conventional Chemotherapy

Author

Ravandi, Farhad, primary, Issa, Jean-Pierre, primary, Garcia-Manero, Guillermo, primary, O’Brien, Susan, primary, Pierce, Sherry, primary, Shan, Jenny, primary, Verstovsek, Srdan, primary, Faderl, Stefan, primary, Cortes, Jorge, primary, and Kantarjian, Hagop, primary

Published
2008
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39. Prognostic Significance of Prior Best Response to Imatinib in Patients (pts) with Chronic Myeloid Leukemia (CML) in Chronic Phase (CP) Treated with Second Generation Tyrosine Kinase Inhibitors (TKIs).

Author

Jabbour, Elias, primary, Kantarjian, Hagop, primary, Shan, Jenny, primary, O’Brien, Susan, primary, Wierda, William, primary, Ravandi, Farhad, primary, Borthakur, Gautam, primary, Kornblau, Steven, primary, Walker, Brenda K., primary, Rios, Mary Beth, primary, and Cortes, Jorge, primary

Published
2007
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44. Delayed Achievement of Molecular Responses Is Associated with Increased Risk of Progression among Patients (pts) with Chronic Myelogenous Leukemia (CML) In Chronic Phase (CP) Treated with Imatinib (IM).

Author

Quintas-Cardama, Alfonso, primary, Kantarjian, Hagop M., primary, Jones, Dan, primary, Garcia-Manero, Guillermo, primary, O’Brien, Susan, primary, Shan, Jenny, primary, Ravandi, Farhad, primary, Wierda, William G., primary, and Cortes, Jorge, primary

Published
2006
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47. Molecular Responses in Patients with Chronic Myelogenous Leukemia in Chronic Phase Treated with Imatinib Mesylate

Author

Cortes, Jorge, primary, Talpaz, Moshe, additional, O'Brien, Susan, additional, Jones, Dan, additional, Luthra, Rajyalakshmi, additional, Shan, Jenny, additional, Giles, Francis, additional, Faderl, Stefan, additional, Verstovsek, Srdan, additional, Garcia-Manero, Guillermo, additional, Rios, Mary B., additional, and Kantarjian, Hagop, additional

Published
2005
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50. MULTI-FACETED RASCH MEASUREMENT AND BIAS PATTERNS IN EFL WRITING PERFORMANCE ASSESSMENT.

Author

TUNG-HSIEN HE, WEN JOHNNY GOU, YA-CHEN CHIEN, I-SHAN JENNY CHEN, and SHAN-MAO CHANG

Subjects
ENGLISH as a foreign language, RASCH models, GRADING of students -- Universities & colleges, RATING of students, COLLEGE graduates
Abstract

This study applied multi-faceted Rasch measurement to examine rater bias in the assessment of essays written by college students learning English as a foreign language. Four raters who had received different academic training from four distinctive disciplines applied a six-category rating scale to analytically rate essays on an argumentative topic and on a descriptive topic. FACETS, a Rasch computer program, was utilized to pinpoint bias patterns by analyzing the rater-topic, rater-category, and topic-category interactions. Results showed: argumentative essays were rated more severely than were descriptive essays; the linguistics-major rater was the most lenient rater, while the literature-major rater was the severest one; and the category of language use received the severest ratings, whereas content was given the most lenient ratings. The severity hierarchies for raters, essay topics, and rating categories suggested that raters' academic training and their perceptions of the importance of categories were associated with their bias patterns. Implications for rater training are discussed. [ABSTRACT FROM AUTHOR]

Published
2013
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