2,612 results on '"Shan, H."'
Search Results
2. Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars
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Li Y, Sun Q, Hao L, Shan H, Jiang Z, Wang Y, Chen Z, Zhu W, and Zhao S
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liposome ,pathological scar ,5-fluorouracil ,fibroblast ,Medicine (General) ,R5-920 - Abstract
Yixin Li,1– 6,* Qi Sun,2,3,7,* Lingjia Hao,1,8 Han Shan,2,3,7 Zixi Jiang,1– 6 Ying Wang,1– 6 Zeyu Chen,2,3,7 Wu Zhu,1– 6 Shuang Zhao1– 6 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2Furong Laboratory (Precision Medicine), Changsha, 410008, People’s Republic of China; 3National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 4Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 5Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 6National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 7School of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, People’s Republic of China; 8Xiangya School of Medicine, Central South University, Changsha, 410083, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuang Zhao; Wu Zhu, Department of Dermatology, Xiangya Hospital of Central South University, 87 Xiangya Road, Kaifu District, Changsha, Hunan Province, People’s Republic of China, Email shuangxy@csu.edu.cn; zhuwuxy@csu.edu.cnIntroduction: Pathological scars, such as hypertrophic scars and keloids, are characterized by the proliferation of fibroblasts and the deposition of collagen that often cause pruritus, pain, and disfigurement. Due to their high incidence and deformity, pathological scars have resulted in severe physical and psychological trauma for patients. Intralesional injection of 5-fluorouracil (5-Fu) is a recommended option for treating pathological scars. However, the efficacy of 5-Fu injection was limited and unstable due to limited drug penetration and short retention time.Methods: Liposomes are promising carriers that have advantages, such as high biocompatibility, controlled release property, and enhanced clinical efficacy. Here, we constructed a transdermal 5-Fu-loaded liposome (5-Fu-Lip) to provide a more effective and safer modality to scar treatment.Results: Compared to 5-Fu, 5-Fu-Lip showed superior ability in inhibiting primary keloid fibroblasts proliferation, migration, and collagen deposition, and also significantly inhibited human umbilical vein endothelial cells (HUVECs) proliferation and microvessel construction. In vivo experiments demonstrated that 5-Fu-Lip can significantly reduce the severity of hypertrophic scars in a rabbit ear wounding model.Discussion: 5-Fu-Lip provides a promising strategy to improve drug efficacy, which has great potential in the treatment of pathological scars.Keywords: liposome, pathological scar, 5-fluorouracil, fibroblast
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- 2024
3. DES Y3 + KiDS-1000: Consistent cosmology combining cosmic shear surveys
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Survey, Dark Energy, Collaboration, Kilo-Degree Survey, Abbott, T. M. C., Aguena, M., Alarcon, A., Alves, O., Amon, A., Andrade-Oliveira, F., Asgari, M., Avila, S., Bacon, D., Bechtol, K., Becker, M. R., Bernstein, G. M., Bertin, E., Bilicki, M., Blazek, J., Bocquet, S., Brooks, D., Burger, P., Burke, D. L., Camacho, H., Campos, A., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C., Chen, R., Choi, A., Conselice, C., Cordero, J., Crocce, M., da Costa, L. N., Pereira, M. E. da Silva, Dalal, R., Davis, C., de Jong, J. T. A., DeRose, J., Desai, S., Diehl, H. T., Dodelson, S., Doel, P., Doux, C., Drlica-Wagner, A., Dvornik, A., Eckert, K., Eifler, T. F., Elvin-Poole, J., Everett, S., Fang, X., Ferrero, I., Ferté, A., Flaugher, B., Friedrich, O., Frieman, J., García-Bellido, J., Gatti, M., Giannini, G., Giblin, B., Gruen, D., Gruendl, R. A., Gutierrez, G., Harrison, I., Hartley, W. G., Herner, K., Heymans, C., Hildebrandt, H., Hinton, S. R., Hoekstra, H., Hollowood, D. L., Honscheid, K., Huang, H., Huff, E. M., Huterer, D., James, D. J., Jarvis, M., Jeffrey, N., Jeltema, T., Joachimi, B., Joudaki, S., Kannawadi, A., Krause, E., Kuehn, K., Kuijken, K., Kuropatkin, N., Lahav, O., Leget, P. -F., Lemos, P., Li, S. -S., Li, X., Liddle, A. R., Lima, M., Lin, C. -A, Lin, H., MacCrann, N., Mahony, C., Marshall, J. L., McCullough, J., Mena-Fernández, J., Menanteau, F., Miquel, R., Mohr, J. J., Muir, J., Myles, J., Napolitano, N., Navarro-Alsina, A., Ogando, R. L. C., Palmese, A., Pandey, S., Park, Y., Paterno, M., Peacock, J. A., Petravick, D., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Prat, J., Radovich, M., Raveri, M., Reischke, R., Robertson, N. C., Rollins, R. P., Romer, A. K., Roodman, A., Rykoff, E. S., Samuroff, S., Sánchez, C., Sanchez, E., Sanchez, J., Schneider, P., Secco, L. F., Sevilla-Noarbe, I., Shan, H. -Y., Sheldon, E., Shin, T., Sifón, C., Smith, M., Soares-Santos, M., Stölzner, B., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., To, C., Troxel, M. A., Tröster, T., Tutusaus, I., Busch, J. L. van den, Varga, T. N., Walker, A. R., Weaverdyck, N., Wechsler, R. H., Weller, J., Wiseman, P., Wright, A. H., Yanny, B., Yin, B., Yoon, M., Zhang, Y., and Zuntz, J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a joint cosmic shear analysis of the Dark Energy Survey (DES Y3) and the Kilo-Degree Survey (KiDS-1000) in a collaborative effort between the two survey teams. We find consistent cosmological parameter constraints between DES Y3 and KiDS-1000 which, when combined in a joint-survey analysis, constrain the parameter $S_8 = \sigma_8 \sqrt{\Omega_{\rm m}/0.3}$ with a mean value of $0.790^{+0.018}_{-0.014}$. The mean marginal is lower than the maximum a posteriori estimate, $S_8=0.801$, owing to skewness in the marginal distribution and projection effects in the multi-dimensional parameter space. Our results are consistent with $S_8$ constraints from observations of the cosmic microwave background by Planck, with agreement at the $1.7\sigma$ level. We use a Hybrid analysis pipeline, defined from a mock survey study quantifying the impact of the different analysis choices originally adopted by each survey team. We review intrinsic alignment models, baryon feedback mitigation strategies, priors, samplers and models of the non-linear matter power spectrum., Comment: 40 pages, 21 figures, 15 tables, accepted Open Journal of Astrophysics. Download the chains from https://des.ncsa.illinois.edu/releases/y3a2/Y3key-joint-des-kids or create your own chains with CosmoSIS using https://github.com/joezuntz/cosmosis-standard-library/blob/main/examples/des-y3_and_kids-1000.ini Watch the core team discuss this analysis at https://cosmologytalks.com/2023/05/26/des-kids
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- 2023
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4. Mechanisms of Action of TMS in the Treatment of Depression
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Downar, Jonathan, Siddiqi, Shan H., Mitra, Anish, Williams, Nolan, Liston, Conor, Ellenbroek, Bart A., Series Editor, Barnes, Thomas R. E., Series Editor, Andersen, Susan L., Series Editor, Paulus, Martin P., Series Editor, Olivier, Jocelien, Series Editor, Browning, Michael, editor, Cowen, Philip J., editor, and Sharp, Trevor, editor
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- 2024
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5. Experimental and numerical study on the bending performance of GFRP/Kraft honeycomb panel after natural aging
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Kong, Z., Kalutskiy, N. S., Shan, H., and Yang, Z.
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- 2024
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6. The future of brain circuit-targeted therapeutics
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Siddiqi, Shan H., Khosravani, Sanaz, Rolston, John D., and Fox, Michael D.
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- 2024
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7. The Relationship Between Insulin Resistance Indicated by Triglyceride and Glucose Index and Left Ventricular Hypertrophy and Decreased Left Ventricular Diastolic Function with Preserved Ejection Fraction
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Yang C, Liu W, Tong Z, Lei F, Lin L, Huang X, Zhang X, Sun T, Wu G, Shan H, Chen S, and Li H
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insulin resistance ,triglyceride and glucose index ,left ventricular hypertrophy ,left ventricular diastolic function ,Specialties of internal medicine ,RC581-951 - Abstract
Chengzhang Yang,1,2,* Weifang Liu,2,3,* Zijia Tong,1,* Fang Lei,3,4 Lijin Lin,2,3 Xuewei Huang,3,5 Xingyuan Zhang,3,6 Tao Sun,2,3 Gang Wu,1 Huajing Shan,1 Shaoze Chen,1 Hongliang Li2,3 1Department of Cardiology, Huanggang Central Hospital, Huanggang, People’s Republic of China; 2Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 3Institute of Model Animal, Wuhan University, Wuhan, People’s Republic of China; 4Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 5Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 6School of Basic Medical Science, Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongliang Li, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China, Tel/Fax +86-27-68759302, Email lihl@whu.edu.cn Shaoze Chen, Department of Cardiology, Huanggang Central Hospital, Huanggang, People’s Republic of China, Tel/Fax +86-713-8381191, Email chenshaoze@hgyy.org.cnAim: The evidence on the association between insulin resistance (IR) and the prevalence or incidence of cardiac dysfunction has been controversial, and the relationship between pre-diabetic IR and cardiac function is lacking. Large sample studies in the Chinese general population are urgently needed to explore the association between IR and the risk of left ventricular hypertrophy (LVH) and decreased left ventricular diastolic function with preserved ejection fraction (LVDFpEF).Methods: Based on a National Health Check-up database in China, we conducted a multicenter cross-sectional retrospective study in 344,420 individuals. Furthermore, at a single center, we performed two retrospective longitudinal studies encompassing 8270 and 5827 individuals to investigate the association between IR and the development of new-onset LVH and LVDFpEF, respectively. The median follow-up duration exceeded 2.5 years. The triglyceride and glucose (TyG) index, known for its high sensitivity in detecting IR, serves as a reliable alternative marker of IR. The logistic and cox proportional hazard regression models were used to determine the relationships.Results: In the cross-sectional study, IR showed a positive association with the prevalence of LVH and decreased LVDFpEF after adjusting for confounders. In the longitudinal cohort, IR was also correlated with the new onset of LVH and decreased LVDFpEF, with hazard ratios (HR) of 1.986 (95% CI: 1.307, 3.017) and 1.386 (95% CI: 1.167, 1.647) in the fourth quartile of TyG levels compared to the lowest quartile, respectively, after adjusting for confounders. The subgroup analysis in non-hypertensive or non-diabetic people and the sensitivity analysis in the population with homeostasis model assessment of insulin resistance (HOMA-IR) further verified the above-mentioned results.Conclusion: IR was associated with LVH and decreased LVDFpEF. Effective management of IR may prevent or delay the development of adverse LVH and decreased LVDFpEF.Keywords: insulin resistance, triglyceride and glucose index, left ventricular hypertrophy, left ventricular diastolic function
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- 2024
8. Mechanisms of Action of TMS in the Treatment of Depression
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Downar, Jonathan, primary, Siddiqi, Shan H., additional, Mitra, Anish, additional, Williams, Nolan, additional, and Liston, Conor, additional
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- 2024
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9. Potential scientific synergies in weak lensing studies between the CSST and Euclid space probes
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Liu, D. Z., Meng, X. M., Er, X. Z., Fan, Z. H., Kilbinger, M., Li, G. L., Li, R., Schrabback, T., Scognamiglio, D., Shan, H. Y., Tao, C., Ting, Y. S., Zhang, J., Cheng, S. H., Farrens, S., Fu, L. P., Hildebrandt, H., Kang, X., Kneib, J. P., Liu, X. K., Mellier, Y., Nakajima, R., Schneider, P., Starck, J. L., Wei, C. L., Wright, A. H., and Zhan, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Aims. With the next generation of large surveys coming to the stage of observational cosmology soon, it is important to explore their potential synergies and to maximise their scientific outcomes. In this study, we aim to investigate the complementarity of the two upcoming space missions Euclid and the China Space Station Telescope (CSST), focusing on weak lensing (WL) cosmology. In particular, we analyse the photometric redshifts (photo-zs) and the galaxy blending effects. For Euclid, WL measurements suffer from chromatic PSF effects. For this, CSST can provide valuable information for Euclid to obtain more accurate PSF, and to calibrate the color and color-gradient biases for WL measurements. Methods. We create image simulations for different surveys, and quantify the photo-z performance. For blending analyses, we employ high-resolution HST/CANDELS data to mock Euclid, CSST, and an LSST-like survey. We analyse the blending fraction for different cases, and the blending effects on galaxy photometry. Furthermore, we demonstrate that CSST can provide a large enough number of high SNR multi-band galaxy images to calibrate the color-gradient biases for Euclid. Results. The sky coverage of Euclid lies entirely within the CSST footprint. The combination of Euclid with CSST data can be done more uniformly than with the various ground-based data. Our studies show that by combining Euclid and CSST, we can reach a photo-z precision of $\sigma_{\rm NMAD} \approx 0.04$, and an outlier fraction of $\eta\approx 2.4\%$. Because of the similarly high resolutions, the data combination of Euclid and CSST can be relatively straightforward for photometry. To include ground-based data, however, sophisticated deblending utilizing priors from high-resolution space data is demanded. The color-gradient biases for Euclid can be well calibrated to the level of 0.1% using galaxies from CSST deep survey., Comment: 18 pages, 19 figures and 2 tables. Accepted for publication in A&A
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- 2022
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10. Multiple sclerosis lesions that impair memory map to a connected memory circuit
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Kletenik, Isaiah, Cohen, Alexander L., Glanz, Bonnie I., Ferguson, Michael A., Tauhid, Shahamat, Li, Jing, Drew, William, Polgar-Turcsanyi, Mariann, Palotai, Miklos, Siddiqi, Shan H., Marshall, Gad A., Chitnis, Tanuja, Guttmann, Charles R. G., Bakshi, Rohit, and Fox, Michael D.
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- 2023
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11. Heterogeneous neuroimaging findings across substance use disorders localize to a common brain network
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Stubbs, Jacob L., Taylor, Joseph J., Siddiqi, Shan H., Schaper, Frederic L. W. V. J., Cohen, Alexander L., Drew, William, Hanlon, Colleen A., Abdolahi, Amir, Wang, Henry Z., Honer, William G., Panenka, William J., and Fox, Michael D.
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- 2023
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12. KiDS-1000: cosmic shear with enhanced redshift calibration
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Busch, J. L. van den, Wright, A. H., Hildebrandt, H., Bilicki, M., Asgari, M., Joudaki, S., Blake, C., Heymans, C., Kannawadi, A., Shan, H. Y., and Tröster, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a cosmic shear analysis with an improved redshift calibration for the fourth data release of the Kilo-Degree Survey (KiDS-1000) using self-organising maps (SOMs). Compared to the previous analysis of the KiDS-1000 data, we expand the redshift calibration sample to more than twice its size, now consisting of data of 17 spectroscopic redshift campaigns, and significantly extending the fraction of KiDS galaxies we are able to calibrate with our SOM redshift methodology. We then enhance the calibration sample with precision photometric redshifts from COSMOS2015 and the Physics of the Accelerated Universe Survey (PAUS), allowing us to fill gaps in the spectroscopic coverage of the KiDS data. Finally we perform a Complete Orthogonal Sets of E/B-Integrals (COSEBIs) cosmic shear analysis of the newly calibrated KiDS sample. We find $S_8 = 0.748_{-0.025}^{+0.021}$, which is in good agreement with previous KiDS studies and increases the tension with measurements of the cosmic microwave background to 3.4{\sigma}. We repeat the redshift calibration with different subsets of the full calibration sample and obtain, in all cases, agreement within at most 0.5{\sigma} in $S_8$ compared to our fiducial analysis. Including additional photometric redshifts allows us to calibrate an additional 6 % of the source galaxy sample. Even though further systematic testing with simulated data is necessary to quantify the impact of redshift outliers, precision photometric redshifts can be beneficial at high redshifts and to mitigate selection effects commonly found in spectroscopically selected calibration samples., Comment: 18 pages, 15 figures, 6 tables
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- 2022
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13. Academic Association through Overseas Visits: A Multiple-Case Study of Chinese Doctoral Students from the Perspectives of A(N)T
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Shan, H., Ren, Z., and Ma, Y.
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Studies of Chinese (visiting) international doctoral students typically focus on how students are socialized into the Western academy. Not only does the literature reinforce Western institutions as 'the academic centre', but it also conjures a unidirectional image of academic learning and knowledge transfer from the West to the rest of the world. This paper complexifies these images by proposing academic association as an alternative image to understand students' experiences. Inspired by assemblage thinking and actor network theory, academic association directs attention to the processes through which students translate themselves within research and knowledge practices and become researchers and knowledge producers. Empirically, drawing on a multiple-case study, this paper traces how 18 short-term Chinese visiting doctoral students built pathways to overseas studies, became enrolled within academic networks and practices, and assembled research and knowledge projects. It also highlights how the students' subjectivities shifted as they knotted themselves into various relations with others, both human and non-human, in the academy. It is argued that as students articulated themselves to 'the academic highways' during their visits, they also multiplied the highways and became, simultaneously, the subjects of academic 'freedom' and 'control'.
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- 2023
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14. Consistent lensing and clustering in a low-$S_8$ Universe with BOSS, DES Year 3, HSC Year 1 and KiDS-1000
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Amon, A., Robertson, N. C., Miyatake, H., Heymans, C., White, M., DeRose, J., Yuan, S., Wechsler, R. H., Varga, T. N., Bocquet, S., Dvornik, A., More, S., Ross, A. J., Hoekstra, H., Alarcon, A., Asgari, M., Blazek, J., Campos, A., Chen, R., Choi, A., Crocce, M., Diehl, H. T., Doux, C., Eckert, K., Elvin-Poole, J., Everett, S., Ferté, A., Gatti, M., Giannini, G., Gruen, D., Gruendl, R. A., Hartley, W. G., Herner, K., Hildebrandt, H., Huang, S., Huff, E. M., Joachimi, B., Lee, S., MacCrann, N., Myles, J., Alsina, A. Navarro, Nishimichi, T., Prat, J., Secco, L. F., Sevilla-Noarbe, I., Sheldon, E., Shin, T., Trster, T., Troxel, M. A., Tutusaus, I., Wright, A. H., Yin, B., Aguena, M., Allam, S., Annis, J., Bacon, D., Bilicki, M., Brooks, D., Burke, D. L., Rosell, A. Carnero, Carretero, J., Castander, F. J., Cawthon, R., Costanzi, M., da Costa, L. N., Pereira, M. E. S., de Jong, J., De Vicente, J., Desai, S., Dietrich, J. P., Doel, P., Ferrero, I., Frieman, J., García-Bellido, J., Gerdes, D. W., Gschwend, J., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Huterer, D., Kannawadi, A., Kuehn, K., Kuropatkin, N., Lahav, O., Lima, M., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Mohr, J. J., Morgan, R., Muir, J., Paz-Chinchon, F., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Rodriguez-Monroy, M., Roodman, A., Sanchez, E., Serrano, S., Shan, H., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., To, C., and Zhang, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We evaluate the consistency between lensing and clustering probes of large-scale structure based on measurements of projected galaxy clustering from BOSS combined with overlapping galaxy-galaxy lensing from three surveys: DES Y3, HSC Y1, and KiDS-1000. An intra-lensing-survey study finds good agreement between these lensing data. We model the observations using the Dark Emulator and fit the data at two fixed cosmologies: Planck, with $S_8=0.83$, and a Lensing cosmology with $S_8=0.76$. For a joint analysis limited to scales with $R>5.25h^{-1}$Mpc, we find that both cosmologies provide an acceptable fit to the data. Full utilisation of the small-scale clustering and lensing measurements is hindered by uncertainty in the impact of baryon feedback and assembly bias, which we account for with a reasoned theoretical error budget. We incorporate a systematic scaling parameter for each redshift bin, $A$, that decouples the lensing and clustering to capture any inconsistency. When a wide range of scales ($0.15
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- 2022
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15. Author Correction: Probing prefrontal-sgACC connectivity using TMS-induced heart–brain coupling
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Dijkstra, Eva S. A., Frandsen, Summer B., van Dijk, Hanneke, Duecker, Felix, Taylor, Joseph J., Sack, Alexander T., Arns, Martijn, and Siddiqi, Shan H.
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- 2024
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16. Accelerated 1 Hz dorsomedial prefrontal transcranial magnetic stimulation for generalized anxiety disorder in adolescents and young adults: A case series
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Paul E. Croarkin, Aleksandra Dojnov, Victoria J. Middleton, Jennifer Bowman, Joseph Kriske, Nancy Donachie, Shan H. Siddiqi, and Jonathan Downar
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2024
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17. A New Angle on Transcranial Magnetic Stimulation Coil Orientation: A Targeted Narrative Review
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Cerins, Andris, Thomas, Elizabeth H.X., Barbour, Tracy, Taylor, Joseph J., Siddiqi, Shan H., Trapp, Nicholas, McGirr, Alexander, Caulfield, Kevin A., Brown, Joshua C., and Chen, Leo
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- 2024
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18. Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites
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Meyer, Garance M., Hollunder, Barbara, Li, Ningfei, Butenko, Konstantin, Dembek, Till A., Hart, Lauren, Nombela, Cristina, Mosley, Philip, Akram, Harith, Acevedo, Nicola, Borron, Benjamin M., Chou, Tina, Castaño Montoya, Juan Pablo, Strange, Bryan, Barcia, Juan A., Tyagi, Himanshu, Castle, David J., Smith, Andrew H., Choi, Ki Sueng, Kopell, Brian H., Mayberg, Helen S., Sheth, Sameer A., Goodman, Wayne K., Leentjens, Albert F.G., Richardson, R. Mark, Rossell, Susan L., Bosanac, Peter, Cosgrove, G. Rees, Kuhn, Jens, Visser-Vandewalle, Veerle, Figee, Martijn, Dougherty, Darin D., Siddiqi, Shan H., Zrinzo, Ludvic, Joyce, Eileen, Baldermann, Juan Carlos, Fox, Michael D., Neudorfer, Clemens, and Horn, Andreas
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- 2024
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19. KiDS & Euclid: Cosmological implications of a pseudo angular power spectrum analysis of KiDS-1000 cosmic shear tomography
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Loureiro, A., Whittaker, L., Mancini, A. Spurio, Joachimi, B., Cuceu, A., Asgari, M., Stölzner, B., Tröster, T., Wright, A. H., Bilicki, M., Dvornik, A., Giblin, B., Heymans, C., Hildebrandt, H., Shan, H., Amara, A., Auricchio, N., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cimatti, A., Cledassou, R., Congedo, G., Conversi, L., Copin, Y., Corcione, L., Cropper, M., Da Silva, A., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Fumana, M., Garilli, B., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Holmes, W., Hormuth, F., Jahnke, K., Kermiche, S., Kiessling, A., Kilbinger, M., Kitching, T., Kümmel, M., Kuijken, K., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lloro, I., Mansutti, O., Marggraf, O., Markovic, K., Marulli, F., Massey, R., Meneghetti, M., Meylan, G., Moresco, M., Morin, B., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Pettorino, V., Pires, S., Poncet, M., Popa, L., Raison, F., Rhodes, J., Rix, H., Roncarelli, M., Saglia, R., Schneider, P., Secroun, A., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Starck, J. L., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Valentijn, E. A., Wang, Y., Welikala, N., Weller, J., Zamorani, G., Zoubian, J., Andreon, S., Baldi, M., Camera, S., Farinelli, R., Polenta, G., and Tessore, N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a tomographic weak lensing analysis of the Kilo Degree Survey Data Release 4 (KiDS-1000), using a new pseudo angular power spectrum estimator (pseudo-$C_{\ell}$) under development for the ESA Euclid mission. Over 21 million galaxies with shape information are divided into five tomographic redshift bins, ranging from 0.1 to 1.2 in photometric redshift. We measured pseudo-$C_{\ell}$ using eight bands in the multipole range $76<\ell<1500$ for auto- and cross-power spectra between the tomographic bins. A series of tests were carried out to check for systematic contamination from a variety of observational sources including stellar number density, variations in survey depth, and point spread function properties. While some marginal correlations with these systematic tracers were observed, there is no evidence of bias in the cosmological inference. B-mode power spectra are consistent with zero signal, with no significant residual contamination from E/B-mode leakage. We performed a Bayesian analysis of the pseudo-$C_{\ell}$ estimates by forward modelling the effects of the mask. Assuming a spatially flat $\Lambda$CDM cosmology, we constrained the structure growth parameter $S_8 = \sigma_8(\Omega_{\rm m}/0.3)^{1/2} = 0.754_{-0.029}^{+0.027}$. When combining cosmic shear from KiDS-1000 with baryon acoustic oscillation and redshift space distortion data from recent Sloan Digital Sky Survey (SDSS) measurements of luminous red galaxies, as well as the Lyman-$\alpha$ forest and its cross-correlation with quasars, we tightened these constraints to $S_8 = 0.771^{+0.006}_{-0.032}$. These results are in very good agreement with previous KiDS-1000 and SDSS analyses and confirm a $\sim 3\sigma$ tension with early-Universe constraints from cosmic microwave background experiments., Comment: 24 pages, 17 figures, Accepted by A&A
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- 2021
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20. An ancient psychedelic for traumatic brain injury
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Brody, David L. and Siddiqi, Shan H.
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- 2024
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21. Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults
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Lee, Soyoung, Zide, Benjamin S., Palm, Stephan T., Drew, William J., Sperling, Reisa A., Jacobs, Heidi I.L., Siddiqi, Shan H., and Donovan, Nancy J.
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- 2024
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22. Toward Personalized Medicine in Connectomic Deep Brain Stimulation
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Hollunder, Barbara, Rajamani, Nanditha, Siddiqi, Shan H., Finke, Carsten, Kühn, Andrea A., Mayberg, Helen S., Fox, Michael D., Neudorfer, Clemens, and Horn, Andreas
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Quantitative Biology - Neurons and Cognition - Abstract
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite "optimal" electrode placement at established treatment coordinates. This may be partly explained by limitations of disease-centric strategies that are unable to account for heterogeneous phenotypes and comorbidities observed in clinical practice. Instead, tailoring electrode placement and programming to individual patients' symptom profiles may increase the fraction of top responding patients. Here, we propose a three-step, circuit-based framework that aims to develop patient-specific treatment targets that address the unique symptom constellation prevalent in each patient. First, we describe how a symptom network target library could be established by mapping beneficial or undesirable DBS effects to distinct circuits based on (retrospective) group-level data. Second, we suggest ways of matching the resulting symptom networks to circuits defined in the individual patient (template matching). Third, we introduce network blending as a strategy to calculate optimal stimulation targets and parameters by selecting and weighting a set of symptom-specific networks based on the symptom profile and subjective priorities of the individual patient. We integrate the approach with published literature and conclude by discussing limitations and future challenges.
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- 2021
23. Older age associated with better antidepressant response to H1-coil transcranial magnetic stimulation in female patients
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Kryatova, Maria S., Seiner, Stephen J., Brown, Joshua C., and Siddiqi, Shan H.
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- 2024
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24. Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression
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Siddiqi, Shan H., Kandala, Sridhar, Hacker, Carl D., Trapp, Nicholas T., Leuthardt, Eric C., Carter, Alexandre R., and Brody, David L.
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- 2023
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25. On the spectral radius of unicyclic and bicyclic graphs with a fixed diameter
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Wang, F. F., Shan, H. Y., and Zhai, Y. Y.
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Mathematics - Combinatorics - Abstract
The $\alpha$-spectral radius of a connected graph $G$ is the spectral radius of $A_\alpha$-matrix of $G$. In this paper, we discuss the methods for comparing $\alpha$-spectral radius of graphs. As applications, we characterize the graphs with the maximal $\alpha$-spectral radius among all unicyclic and bicyclic graphs of order $n$ with diameter $d$, respectively. Finally, we determine the unique graph with maximal signless Laplacian spectral radius among bicyclic graphs of order $n$ with diameter $d$.
- Published
- 2021
26. Case Report: Severe Diarrhea Caused by Cryptosporidium Diagnosed by Metagenome Next-Generation Sequencing in Blood
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Shan H, Wei C, Zhang J, He M, and Zhang Z
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nitazoxanide ,cryptosporidiosis ,cryptosporidium ,transplant recipient ,azithromycin ,Infectious and parasitic diseases ,RC109-216 - Abstract
Huifang Shan,1 Chunyan Wei,1 Jingyi Zhang,1 Min He,2 Zhongwei Zhang2 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Zhongwei Zhang, Email 716461751@qq.comBackground: Cryptosporidium is one of the major pathogens causing diarrhea worldwide. At present, cryptosporidiosis is difficult to prevent and control, especially in immunocompromised hosts. It may cause life-threatening diarrhea and malabsorption among children and immunocompromised patients. Therefore, it is very important to explore rapid diagnostic tools and treatment methods for Cryptosporidium infection.Case Presentation: We reported a case of severe diarrhea caused by cryptosporidiosis in a liver transplant recipient, whose condition was finally confirmed by metagenomic next-generation sequencing (mNGS) and fecal microscopy. His illness was resolved with immunosuppression regulation, nitazoxanide administration, and infection control.Conclusion: So far, nitazoxanide is still the first choice for the treatment of cryptosporidiosis. Our institutional experience suggested that nitazoxanide alone may be effective on the basis of adjusting immunosuppressant. In addition, even though diagnosis of Cryptosporidium infection is a challenge, mNGS can serve as a rapid screening tool in low-prevalence setting.Keywords: nitazoxanide, cryptosporidiosis, Cryptosporidium, transplant recipient, azithromycin
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- 2023
27. Targeting Symptom-Specific Networks With Transcranial Magnetic Stimulation
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Siddiqi, Shan H. and Fox, Michael D.
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- 2024
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28. Lesion voxels to lesion networks: The enduring value of the Vietnam Head Injury Study
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Howard, Calvin W., Ferguson, Michael H., Siddiqi, Shan H., and Fox, Michael D.
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- 2024
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29. Critically Assessing the Unanswered Questions of How, Where, and When to Induce Plasticity in the Posttraumatic Stress Disorder Network With Transcranial Magnetic Stimulation
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Brown, Joshua C., Kweon, Jamie, Sharma, Prayushi, Siddiqi, Shan H., Isserles, Moshe, and Ressler, Kerry J.
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- 2024
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30. Bright galaxy sample in the Kilo-Degree Survey Data Release 4: selection, photometric redshifts, and physical properties
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Bilicki, M., Dvornik, A., Hoekstra, H., Wright, A. H., Chisari, N. E., Vakili, M., Asgari, M., Giblin, B., Heymans, C., Hildebrandt, H., Holwerda, B. W., Hopkins, A., Johnston, H., Kannawadi, A., Kuijken, K., Nakoneczny, S. J., Shan, H. Y., Sonnenfeld, A., and Valentijn, E.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a bright galaxy sample with accurate and precise photometric redshifts (photo-zs), selected using $ugriZYJHK_\mathrm{s}$ photometry from the Kilo-Degree Survey (KiDS) Data Release 4 (DR4). The highly pure and complete dataset is flux-limited at $r<20$ mag, covers $\sim1000$ deg$^2$, and contains about 1 million galaxies after artifact masking. We exploit the overlap with Galaxy And Mass Assembly (GAMA) spectroscopy as calibration to determine photo-zs with the supervised machine learning neural network algorithm implemented in the ANNz2 software. The photo-zs have mean error of $|\langle \delta z \rangle| \sim 5 \times 10^{-4}$ and low scatter (scaled mean absolute deviation of $\sim 0.018(1+z)$), both practically independent of the $r$-band magnitude and photo-z at $0.05 < z_\mathrm{phot} < 0.5$. Combined with the 9-band photometry, these allow us to estimate robust absolute magnitudes and stellar masses for the full sample. As a demonstration of the usefulness of these data we split the dataset into red and blue galaxies, use them as lenses and measure the weak gravitational lensing signal around them for five stellar mass bins. We fit a halo model to these high-precision measurements to constrain the stellar-mass--halo-mass relations for blue and red galaxies. We find that for high stellar mass ($M_\star>5\times 10^{11} M_\odot$), the red galaxies occupy dark matter halos that are much more massive than those occupied by blue galaxies with the same stellar mass. The data presented here are publicly released via the KiDS webpage at http://kids.strw.leidenuniv.nl/DR4/brightsample.php., Comment: Matches the published version. Data available at http://kids.strw.leidenuniv.nl/DR4/brightsample.php
- Published
- 2021
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31. CODEX Weak Lensing Mass Catalogue and implications on the mass-richness relation
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Kiiveri, K., Gruen, D., Finoguenov, A., Erben, T., van Waerbeke, L., Rykoff, E., Miller, L., Hagstotz, S., Dupke, R., Henry, J. Patrick, Kneib, J-P., Gozaliasl, G., Kirkpatrick, C. C., Cibirka, N., Clerc, N., Costanzi, M., Cypriano, E. S., Rozo, E., Shan, H., Spinelli, P., Valiviita, J., and Weller, J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The COnstrain Dark Energy with X-ray clusters (CODEX) sample contains the largest flux limited sample of X-ray clusters at $0.35 < z < 0.65$. It was selected from ROSAT data in the 10,000 square degrees of overlap with BOSS, mapping a total number of 2770 high-z galaxy clusters. We present here the full results of the CFHT CODEX program on cluster mass measurement, including a reanalysis of CFHTLS Wide data, with 25 individual lensing-constrained cluster masses. We employ $lensfit$ shape measurement and perform a conservative colour-space selection and weighting of background galaxies. Using the combination of shape noise and an analytic covariance for intrinsic variations of cluster profiles at fixed mass due to large scale structure, miscentring, and variations in concentration and ellipticity, we determine the likelihood of the observed shear signal as a function of true mass for each cluster. We combine 25 individual cluster mass likelihoods in a Bayesian hierarchical scheme with the inclusion of optical and X-ray selection functions to derive constraints on the slope $\alpha$, normalization $\beta$, and scatter $\sigma_{\ln \lambda | \mu}$ of our richness-mass scaling relation model in log-space: $\left<\ln \lambda | \mu \right> = \alpha \mu + \beta$, with $\mu = \ln (M_{200c}/M_{\mathrm{piv}})$, and $M_{\mathrm{piv}} = 10^{14.81} M_{\odot}$. We find a slope $\alpha = 0.49^{+0.20}_{-0.15}$, normalization $ \exp(\beta) = 84.0^{+9.2}_{-14.8}$ and $\sigma_{\ln \lambda | \mu} = 0.17^{+0.13}_{-0.09}$ using CFHT richness estimates. In comparison to other weak lensing richness-mass relations, we find the normalization of the richness statistically agreeing with the normalization of other scaling relations from a broad redshift range ($0.0
- Published
- 2021
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32. Discovery of two Einstein crosses from massive post--blue nugget galaxies at z>1 in KiDS
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Napolitano, N. R., Li, R., Spiniello, C., Tortora, C., Sergeyev, A., D'Ago, G., Guo, X., Xie, L., Radovich, M., Roy, N., Koopmans, L. V. E., Kuijken, K., Bilicki, M., Erben, T., Getman, F., Heymans, C., Hildebrandt, H., Moya, C., Shan, H. Y., Vernardos, G., and Wright, A. H.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the discovery of two Einstein Crosses (ECs) in the footprint of the Kilo-Degree Survey (KiDS): KIDS J232940-340922 and KIDS J122456+005048. Using integral field spectroscopy from MUSE@VLT, we confirm their gravitational-lens nature. In both cases, the four spectra of the source clearly show a prominence of absorption features, hence revealing an evolved stellar population with little star formation. The lensing model of the two systems, assuming a singular isothermal ellipsoid (SIE) with external shear, shows that: 1) the two crosses, located at redshift $z=0.38$ and 0.24, have Einstein radius $R_{\rm E}=5.2$ kpc and 5.4 kpc, respectively; 2) their projected dark matter fractions inside the half effective radius are 0.60 and 0.56 (Chabrier IMF); 3) the sources are ultra-compact galaxies, $R_{\rm e}\sim0.9$ kpc (at redshift $z_{\rm s}=1.59$) and $R_{\rm e}\sim0.5$ kpc ($z_{\rm s}=1.10$), respectively. These results are unaffected by the underlying mass density assumption. Due to size, blue color and absorption-dominated spectra, corroborated by low specific star-formation rates derived from optical-NIR spectral energy distribution fitting, we argue that the two lensed sources in these ECs are blue nuggets migrating toward their quenching phase., Comment: Accepted for publication on APJL
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- 2020
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33. A transdiagnostic network for psychiatric illness derived from atrophy and lesions
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Taylor, Joseph J., Lin, Christopher, Talmasov, Daniel, Ferguson, Michael A., Schaper, Frederic L. W. V. J., Jiang, Jing, Goodkind, Madeleine, Grafman, Jordan, Etkin, Amit, Siddiqi, Shan H., and Fox, Michael D.
- Published
- 2023
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34. Lesion network localization of depression in multiple sclerosis
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Siddiqi, Shan H., Kletenik, Isaiah, Anderson, Mark C., Cavallari, Michele, Chitnis, Tanuja, Glanz, Bonnie I., Khalil, Samar, Palotai, Miklos, Bakshi, Rohit, Guttmann, Charles R. G., and Fox, Michael D.
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- 2023
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35. KiDS-1000 catalogue: Redshift distributions and their calibration
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Hildebrandt, H., Busch, J. L. van den, Wright, A. H., Blake, C., Joachimi, B., Kuijken, K., Tröster, T., Asgari, M., Bilicki, M., de Jong, J. T. A., Dvornik, A., Erben, T., Getman, F., Giblin, B., Heymans, C., Kannawadi, A., Lin, C. -A., and Shan, H. -Y.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present redshift distribution estimates of galaxies selected from the fourth data release of the Kilo-Degree Survey over an area of $\sim1000$ deg$^2$ (KiDS-1000). These redshift distributions represent one of the crucial ingredients for weak gravitational lensing measurements with the KiDS-1000 data. The primary estimate is based on deep spectroscopic reference catalogues that are re-weighted with the help of a self-organising map (SOM) to closely resemble the KiDS-1000 sources, split into five tomographic redshift bins in the photometric redshift range $0.1
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- 2020
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36. KiDS-1000 Methodology: Modelling and inference for joint weak gravitational lensing and spectroscopic galaxy clustering analysis
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Joachimi, B., Lin, C. -A., Asgari, M., Tröster, T., Heymans, C., Hildebrandt, H., Köhlinger, F., Sánchez, A. G., Wright, A. H., Bilicki, M., Blake, C., Busch, J. L. van den, Crocce, M., Dvornik, A., Erben, T., Getman, F., Giblin, B., Hoekstra, H., Kannawadi, A., Kuijken, K., Napolitano, N. R., Schneider, P., Scoccimarro, R., Sellentin, E., Shan, H. Y., von Wietersheim-Kramsta, M., and Zuntz, J.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the methodology for a joint cosmological analysis of weak gravitational lensing from the fourth data release of the ESO Kilo-Degree Survey (KiDS-1000) and galaxy clustering from the partially overlapping BOSS and 2dFLenS surveys. Cross-correlations between galaxy positions and ellipticities have been incorporated into the analysis, necessitating a hybrid model of non-linear scales that blends perturbative and non-perturbative approaches, and an assessment of contributions by astrophysical effects. All weak lensing signals are measured consistently via Fourier-space statistics that are insensitive to the survey mask and display low levels of mode mixing. The calibration of photometric redshift distributions and multiplicative gravitational shear bias has been updated, and a more complete tally of residual calibration uncertainties is propagated into the likelihood. A dedicated suite of more than 20000 mocks is used to assess the performance of covariance models and to quantify the impact of survey geometry and spatial variations of survey depth on signals and their errors. The sampling distributions for the likelihood and the $\chi^2$ goodness-of-fit statistic have been validated, with proposed changes to the number of degrees of freedom. Standard weak lensing point estimates on $S_8=\sigma_8\,(\Omega_{\rm m}/0.3)^{1/2}$ derived from its marginal posterior are easily misinterpreted to be biased low, and an alternative estimator and associated credible interval have been proposed. Known systematic effects pertaining to weak lensing modelling and inference are shown to bias $S_8$ by no more than 0.1 standard deviations, with the caveat that no conclusive validation data exist for models of intrinsic galaxy alignments. Compared to the previous KiDS analyses, $S_8$ constraints are expected to improve by 20% for weak lensing alone and by 29% for the joint analysis. [abridged], Comment: 45 pages, 34 figures, 7 tables; minor changes to match version accepted by A&A. The KiDS-1000 data products are available for download at http://kids.strw.leidenuniv.nl/DR4/lensing.php. This data release includes open source software, the shear-photo-z catalogue, the cosmic shear and 3x2pt data vectors and covariances, and posteriors in the form of Multinest chains
- Published
- 2020
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37. Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression
- Author
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Shan H. Siddiqi, Sridhar Kandala, Carl D. Hacker, Nicholas T. Trapp, Eric C. Leuthardt, Alexandre R. Carter, and David L. Brody
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Medicine ,Science - Abstract
Abstract At the group level, antidepressant efficacy of rTMS targets is inversely related to their normative connectivity with subgenual anterior cingulate cortex (sgACC). Individualized connectivity may yield better targets, particularly in patients with neuropsychiatric disorders who may have aberrant connectivity. However, sgACC connectivity shows poor test–retest reliability at the individual level. Individualized resting-state network mapping (RSNM) can reliably map inter-individual variability in brain network organization. Thus, we sought to identify individualized RSNM-based rTMS targets that reliably target the sgACC connectivity profile. We used RSNM to identify network-based rTMS targets in 10 healthy controls and 13 individuals with traumatic brain injury-associated depression (TBI-D). These “RSNM targets” were compared with consensus structural targets and targets based on individualized anti-correlation with a group-mean-derived sgACC region (“sgACC-derived targets”). The TBI-D cohort was also randomized to receive active (n = 9) or sham (n = 4) rTMS to RSNM targets with 20 daily sessions of sequential high-frequency left-sided stimulation and low-frequency right-sided stimulation. We found that the group-mean sgACC connectivity profile was reliably estimated by individualized correlation with default mode network (DMN) and anti-correlation with dorsal attention network (DAN). Individualized RSNM targets were thus identified based on DAN anti-correlation and DMN correlation. These RSNM targets showed greater test–retest reliability than sgACC-derived targets. Counterintuitively, anti-correlation with the group-mean sgACC connectivity profile was also stronger and more reliable for RSNM-derived targets than for sgACC-derived targets. Improvement in depression after RSNM-targeted rTMS was predicted by target anti-correlation with the portions of sgACC. Active treatment also led to increased connectivity within and between the stimulation sites, the sgACC, and the DMN. Overall, these results suggest that RSNM may enable reliable individualized rTMS targeting, although further research is needed to determine whether this personalized approach can improve clinical outcomes.
- Published
- 2023
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38. Carbon Dots-Based Nanozyme for Drug-Resistant Lung Cancer Therapy by Encapsulated Doxorubicin/siRNA Cocktail
- Author
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Yu H, Tang K, Cai Z, Lin X, Huang Y, Yu T, Zhang Q, Wang Q, Wu L, Yang L, Shan H, and Luo H
- Subjects
carbon dots ,chemoresistance ,co-delivery ,sirna ,Medicine (General) ,R5-920 - Abstract
Hailing Yu,1,* Kexin Tang,1,* Zeyu Cai,2,* Xi Lin,1 Yongquan Huang,3 Ting Yu,1 Qianqian Zhang,1 Qiang Wang,4 Lili Wu,5 Lei Yang,6 Hong Shan,1 Hui Luo1 1Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, People’s Republic of China; 2Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 3Department of Ultrasound, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 4The Green Aerotechnics Research Institute of Chongqing Jiaotong University, Chongqing, People’s Republic of China; 5Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin, Heilongjiang, People’s Republic of China; 6Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Luo; Hong Shan, Email luoh53@mail.sysu.edu.cn; shanhong@mail.sysu.edu.cnBackground: Nanomaterials exhibited intrinsic enzyme-like properties due to the unique properties compared with natural enzyme. Carbon dots (CDs) are an important kind of quantum-sized nanomaterials, which have enormous application potential in bio-imaging, drug carrier, and nanosystems. Carbon dots possess intrinsic enzyme-like properties, such as glutathione (GSH) oxidase or peroxidase activities.Methods: A co-delivery nanosystem that could carry siRNA and doxorubucin (DOX) simultaneously has been studied in this work. The co-delivery based on carbon dots was surface-modified with poly-ethylenimine (PEI) and loaded the siMRP1 with chemotherapeutics on the surface with pH-triggered drug release. The CD-PEI was synthesized by one-step microwave assisted method; the PEI was raw materials and passivator during the reaction process that makes CDs exhibit excellent optical property.Results: The CD-PEI was capable of loading and delivering siMRP1 and DOX to tumors and releasing them synchronously in cells in an acid-triggered manner. The particles exhibited GSH oxidase-like catalytic property, oxidizing GSH to oxidized glutathione with concomitant increase of reactive oxygen species (ROS). We found that silencing of MRP1 by co-delivery system antagonized chemoresistance by increasing DOX accumulation and significantly enhancing the inhibitory effect of cell viability induced by CD-PEI-DOX. The co-delivery system dramatically inhibited tumor growth in xenograft model, and CDs counteracted MRP1 function by siRNA-mediated knockdown of MRP1.Conclusion: Taken together, we uncover the potential role of CDs with a combination of siRNA and chemotherapeutics in overcoming chemoresistance of lung cancer by suppressing MRP1 and oxidation of GSH. Our findings imply its potential of antagonizing chemoresistance to enhance therapeutic efficiency of doxorubicin in clinical practices of lung cancer treatment.Keywords: carbon dots, chemoresistance, co-delivery, siRNA
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- 2023
39. How Machine Learning is Powering Neuroimaging to Improve Brain Health
- Author
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Singh, Nalini M., Harrod, Jordan B., Subramanian, Sandya, Robinson, Mitchell, Chang, Ken, Cetin-Karayumak, Suheyla, Dalca, Adrian Vasile, Eickhoff, Simon, Fox, Michael, Franke, Loraine, Golland, Polina, Haehn, Daniel, Iglesias, Juan Eugenio, O’Donnell, Lauren J., Ou, Yangming, Rathi, Yogesh, Siddiqi, Shan H., Sun, Haoqi, Westover, M. Brandon, Whitfield-Gabrieli, Susan, and Gollub, Randy L.
- Published
- 2022
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40. Testing gravity with galaxy-galaxy lensing and redshift-space distortions using CFHT-Stripe 82, CFHTLenS and BOSS CMASS datasets
- Author
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Jullo, E., de la Torre, S., Cousinou, M. -C., Escoffier, S., Giocoli, C., Metcalf, R. Benton, Comparat, J., Shan, H. -Y., Makler, M., Kneib, J. -P., Prada, F., Yepes, G., and Gottlöber, S.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The combination of Galaxy-Galaxy Lensing (GGL) and Redshift Space Distortion of galaxy clustering (RSD) is a privileged technique to test General Relativity predictions, and break degeneracies between the growth rate of structure parameter $f$ and the amplitude of the linear power-spectrum $\sigma_8$. We perform a joint GGL and RSD analysis on 250 sq. degrees using shape catalogues from CFHTLenS and CFHT-Stripe 82, and spectroscopic redshifts from the BOSS CMASS sample. We adjust a model that includes non-linear biasing, RSD and Alcock-Paczynski effects. We find $f(z=0.57) =0.95\pm0.23$, $\sigma_8(z=0.57)=0.55\pm0.07$ and $\Omega_{\rm m} = 0.31\pm0.08$, in agreement with Planck cosmological results 2018. We also estimate the probe of gravity $E_{\rm G} = 0.43\pm0.10$ in agreement with $\Lambda$CDM-GR predictions of $E_{\rm G} = 0.40$. This analysis reveals that RSD efficiently decreases the GGL uncertainty on $\Omega_{\rm m}$ by a factor of 4, and by 30\% on $\sigma_8$. We use an N-body simulation supplemented by an abundance matching prescription for CMASS to build a set of overlapping lensing and clustering mocks. Together with additional spectroscopic data, this helps us to quantify and correct several systematic errors, such as photometric redshifts. We make our mock catalogues available on the Skies and Universe database., Comment: 19 pages, 14 figures, re-submitted to A&A. Mock catalogues available at http://www.skiesanduniverses.org
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- 2019
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41. The fourth data release of the Kilo-Degree Survey: ugri imaging and nine-band optical-IR photometry over 1000 square degrees
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Kuijken, K., Heymans, C., Dvornik, A., Hildebrandt, H., de Jong, J. T. A., Wright, A. H., Erben, T., Bilicki, M., Giblin, B., Shan, H. -Y., Getman, F., Grado, A., Hoekstra, H., Miller, L., Napolitano, N., Paolilo, M., Radovich, M., Schneider, P., Sutherland, W., Tewes, M., Tortora, C., Valentijn, E. A., and Kleijn, G. A. Verdoes
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Kilo-Degree Survey (KiDS) is an ongoing optical wide-field imaging survey with the OmegaCAM camera at the VLT Survey Telescope, specifically designed for measuring weak gravitational lensing by galaxies and large-scale structure. When completed it will consist of 1350 square degrees imaged in four filters (ugri). Here we present the fourth public data release which more than doubles the area of sky covered by data release 3. We also include aperture-matched ZYJHKs photometry from our partner VIKING survey on the VISTA telescope in the photometry catalogue. We illustrate the data quality and describe the catalogue content. Two dedicated pipelines are used for the production of the optical data. The Astro-WISE information system is used for the production of co-added images in the four survey bands, while a separate reduction of the r-band images using the theli pipeline is used to provide a source catalogue suitable for the core weak lensing science case. All data have been re-reduced for this data release using the latest versions of the pipelines. The VIKING photometry is obtained as forced photometry on the theli sources, using a re-reduction of the VIKING data that starts from the VISTA pawprints. Modifications to the pipelines with respect to earlier releases are described in detail. The photometry is calibrated to the Gaia DR2 G band using stellar locus regression. In this data release a total of 1006 square-degree survey tiles with stacked ugri images are made available, accompanied by weight maps, masks, and single-band source lists. We also provide a multi-band catalogue based on r-band detections, including homogenized photometry and photometric redshifts, for the whole dataset. Mean limiting magnitudes (5 sigma in a 2" aperture) are 24.23, 25.12, 25.02, 23.68 in ugri, respectively, and the mean r-band seeing is 0.70"., Comment: 25 pages, accepted for publication in Astronomy and Astrophysics. For access to the images and catalogues see http://kids.strw.leidenuniv.nl/DR4/
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- 2019
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42. LinKS: Discovering galaxy-scale strong lenses in the Kilo-Degree Survey using Convolutional Neural Networks
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Petrillo, C. E., Tortora, C., Vernardos, G., Koopmans, L. V. E., Kleijn, G. Verdoes, Bilicki, M., Napolitano, N. R., Chatterjee, S., Covone, G., Dvornik, A., Erben, T., Getman, F., Giblin, B., Heymans, C., de Jong, J. T. A., Kuijken, K., Schneider, P., Shan, H., Spiniello, C., and Wright, A. H.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present a new sample of galaxy-scale strong gravitational-lens candidates, selected from 904 square degrees of Data Release 4 of the Kilo-Degree Survey (KiDS), i.e., the "Lenses in the Kilo-Degree Survey" (LinKS) sample. We apply two Convolutional Neural Networks (ConvNets) to $\sim88\,000$ colour-magnitude selected luminous red galaxies yielding a list of 3500 strong-lens candidates. This list is further down-selected via human inspection. The resulting LinKS sample is composed of 1983 rank-ordered targets classified as "potential lens candidates" by at least one inspector. Of these, a high-grade subsample of 89 targets is identified with potential strong lenses by all inspectors. Additionally, we present a collection of another 200 strong lens candidates discovered serendipitously from various previous ConvNet runs. A straightforward application of our procedure to future Euclid or LSST data can select a sample of $\sim3000$ lens candidates with less than 10 per cent expected false positives and requiring minimal human intervention., Comment: 19 pages, 11 figures, accepted for publication in MNRAS
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- 2018
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43. Circuit-Targeted Neuromodulation for Anhedonia
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Siddiqi, Shan H., Haddad, Nichola, Fox, Michael D., Geyer, Mark A., Series Editor, Marsden, Charles A., Series Editor, Ellenbroek, Bart A., Series Editor, Barnes, Thomas R.E., Series Editor, Andersen, Susan L., Series Editor, Paulus, Martin P., Series Editor, and Pizzagalli, Diego A., editor
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- 2022
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44. Wavelet based tone mapping (TM) enhancement to a detection system for faint and compact sources in HDR and large FOV radio scenes
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Shan, H., Cui, L., Hong, X.Y., Liu, X., and Chang, N.
- Published
- 2023
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45. Real-World Outcomes and Predictors of Accelerated rTMS Treatment Response for Treatment-Resistant Depression
- Author
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DeSouza, Danielle D, primary, Nakano, Erica, additional, Hoang, Vivian, additional, Hoang, Kim, additional, Ling, David, additional, Muir, Owen, additional, Meng, Nathan, additional, DeGaetano, Noah, additional, Siddiqi, Shan H, additional, and Carreon, David, additional
- Published
- 2024
- Full Text
- View/download PDF
46. Lesions that Cause Psychosis Map to a Common Brain Circuit in the Hippocampus
- Author
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Pines, Andrew R, primary, Frandsen, Summer B, additional, Drew, William, additional, Meyer, Garance M, additional, Howard, Calvin, additional, Palm, Stephan T, additional, Schaper, Frederic L.W.V.J., additional, Lin, Christopher, additional, Butenko, Konstantin, additional, Ferguson, Michael A, additional, Friedrich, Maximilian U, additional, Grafman, Jordan H, additional, Kappel, Ari D, additional, Neudorfer, Clemens, additional, Rost, Natalia S, additional, Sanderson, Lauren L, additional, Wu, Ona, additional, Kletenik, Isaiah, additional, Vogel, Jacob W, additional, Cohen, Alexander L, additional, Horn, Andreas, additional, Fox, Michael D, additional, Silbersweig, David, additional, and Siddiqi, Shan H, additional
- Published
- 2024
- Full Text
- View/download PDF
47. CRISPR-Cas Genome Editing in Ex Vivo Human Lungs
- Author
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Mesaki, K., primary, Yamamoto, H., additional, Juvet, S., additional, Yeung, J., additional, Guan, Z., additional, Yao, Y., additional, Chen, M., additional, Gokhale, H., additional, Shan, H., additional, Wang, A., additional, Wilson, G., additional, Mariscal, A., additional, Hu, J., additional, Davidson, A., additional, Kleinstiver, B., additional, Cypel, M., additional, Liu, M., additional, and Keshavjee, S., additional
- Published
- 2024
- Full Text
- View/download PDF
48. CRISPR Genome Engineering in Donor Lung During Cyclic EVLP with 10°C Preservation: Usage of TorEx Lung Perfusion System
- Author
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Yoshiyasu, N., primary, Mariscal, A., additional, Salvador, A., additional, Hough, O., additional, Yamamoto, H., additional, Gokhale, H., additional, Shan, H., additional, Chen, M., additional, Guan, Z., additional, Suzuki, Y., additional, Yao, Y., additional, Mesaki, K., additional, Nagoya, A., additional, Juvet, S., additional, Waddell, T.K., additional, Liu, M., additional, Cypel, M., additional, and Keshavjee, S., additional
- Published
- 2024
- Full Text
- View/download PDF
49. Older Age Associated with Better Antidepressant Response to Deep Transcranial Magnetic Stimulation
- Author
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Maria S. Kryatova, Stephen J. Seiner, Joshua C. Brown, and Shan H. Siddiqi
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2023
- Full Text
- View/download PDF
50. Brain lesions disrupting addiction map to a common human brain circuit
- Author
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Joutsa, Juho, Moussawi, Khaled, Siddiqi, Shan H., Abdolahi, Amir, Drew, William, Cohen, Alexander L., Ross, Thomas J., Deshpande, Harshawardhan U., Wang, Henry Z., Bruss, Joel, Stein, Elliot A., Volkow, Nora D., Grafman, Jordan H., van Wijngaarden, Edwin, Boes, Aaron D., and Fox, Michael D.
- Published
- 2022
- Full Text
- View/download PDF
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