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Inflammation is one of the pertinent responses of the body, depending mainly on the process and factors involved in combating the oxidative species produced either by any infection or failure of the antioxidant pathways. In search of new compounds to exhibit antioxidant and anti-inflammatory activity here, we have successfully reported the synthesis of three novel compounds of Piperidin-4-one skeleton by adopting simple and convenient methods. Compound 1, (3, 3-dimethyl-2, 6-bis(3,4,5-trimethoxyphenyl) piperidin-4-one) was synthesized by one-pot Mannich condensation reaction having good yield (88 %). Furthermore in the next step highly functionalized imine derivatives, Compound 2 (3,3-dimethyl-2,6-bis (3,4,5-trimethoxyphenyl) piperidine-4-one) hydrazine carbothioamide) and Compound 3 (3,3-dimethyl-2,6-bis(3,4,5-trimethoxyphenyl) piperidin-4-one oxime) were prepared by the condensation reaction with thiosemicarbazide and hydroxylamine hydrochloride with compound 1, respectively. The structure of the compounds has been deduced by the combined use of modern spectroscopic and single crystal x-ray diffraction (XRD) techniques. in-silico ADMET studies predict pharmacokinetic properties and showed that compounds are non toxic on vital organs. The optimized geometry and reactivity parameters of compounds were further calculated based on the B3LYP/6-31G (d, p) density functional theory (DFT). The negative values of chemical potential follow the trend as 2 (−0.2101) > 3 (−0.2198) > 1(-0.2233) signifies that all compounds are reactive in nature as evident from in-vitro antioxidant and anti-inflammatory response were determined by using the DDPH assay and protein denaturation methods respectively. Compounds possess good radical scavenging activity having IC 50 values 30.392 μM (2), 37.802 (1) μM, and 72.285 (3) μM, and anti-inflammatory response in same manner indicating that 2 (71.3 %) is more active than compound 1 (43.5 %) and 3 (39.3 %) marking them as a potential antioxidant and anti-inflammatory agents.

The consideration of students’ emotional and psychological health is crucial to facilitate effective teaching and grading practices. This study set out to shed light on the interplay between self-esteem (S-E), cognitive-emotion regulation (CER), academic enjoyment (AE), and language success (LS) in artificial intelligence (AI)-supported online language learning. To this end, the foreign language learning self-esteem scale, the Cognitive Emotion Control Questionnaire, the foreign language enjoyment scale, and a researcher-made test were distributed to 389 English as a foreign language learners in China. Screening the data with confirmatory factor analysis and structural equation modeling, the effects of S-E, CER, AE, and LS were identified and quantified. These results highlighted the important function that online courses assisted by AI perform in enhancing students’ CER and AE. This implied that students who have cultivated a robust sense of self-efficacy are adept at effectively regulating their cognitive and affective processes in AI-supported language learning. Possible improvements in language education are discussed, as are the study’s broader implications.

Abstract Consequential validity, a facet of construct validity, has been extensively explored by educational psychologists and scholars focused on English language assessment. It is widely recognized that English language instructors must possess a thorough understanding of high-stake language tests. However, the body of research concerning EFL teachers’ perceptions of high-stake tests is quite limited. This study aims to delve into the cognitions of Iranian EFL teachers regarding the social and psychological ramifications of high-stake English language tests. Additionally, the study investigates the influence of a teacher training workshop on EFL teachers’ perceptions of test consequences. The research employs a two-phase quantitative research design. A total of 210 EFL teachers participated in the survey, completing a scale comprising 25 items that delineated their perceptions of test consequences. Furthermore, thirty teachers engaged in a two-session workshop focused on test consequences. Data analysis encompassed both one-sample and paired-sample t tests. The results reveal that EFL teachers possess knowledge regarding certain social and psychological consequences of language tests; however, their awareness of some adverse consequences remains limited. Notably, the outcomes indicate that teacher training workshops have a positive impact on teachers’ cognitions of both positive and negative test consequences. The implications of these findings extend to teacher trainers and English language educators, offering practical insights to enhance the effectiveness of their teaching practices.

Objective: Regular physical activity is beneficial to both physical and emotional well-being. The present study goal is to observe how lack of physical exercise leads to various noncommunicable diseases. Methodology:A study was conducted at Central Park Housing Society, Lahore using cross sectional study design. Data was collected from 250 residents of Lahore, Pakistan’s Central Park Housing Society using the structured tool IPAQ-LF. Structured tool used in this study was applicable on age group between 15-69 years, therefore we included participants aged between 15-69 years in this study. While children, adolescences having age between 10-14 years, adults > 69 years old, pregnant women and those with existing non- communicable diseases were excluded from the study. The Kruskal-Wallis ANOVA test was used to determine whether there was a significant relationship between physical activity and non-communicable diseases. Results: About 20.8% participants had family history of hypertension. Greater physical activity is linked to reduce hypertension risk. Lower physical activity is associated with a higher diabetes risk (18%) compared to the higher activity levels (14%). BMI (p-value=0.00) and random blood sugar level (p-value=0.03) is associated with physical activity. Conclusion: Most of the participants were not involved in moderate physical activity. People who participated in physical activities are at a lower risk of developing diabetes and hypertension. In general, physical activity aids in mitigating harmful chronic diseases.

Objective: Regular physical activity is beneficial to both physical and emotional well-being. The present study goal is to observe how lack of physical exercise leads to various noncommunicable diseases. Methodology:A study was conducted at Central Park Housing Society, Lahore using cross sectional study design. Data was collected from 250 residents of Lahore, Pakistan’s Central Park Housing Society using the structured tool IPAQ-LF. Structured tool used in this study was applicable on age group between 15-69 years, therefore we included participants aged between 15-69 years in this study. While children, adolescences having age between 10-14 years, adults > 69 years old, pregnant women and those with existing non- communicable diseases were excluded from the study. The Kruskal-Wallis ANOVA test was used to determine whether there was a significant relationship between physical activity and non-communicable diseases. Results: About 20.8% participants had family history of hypertension. Greater physical activity is linked to reduce hypertension risk. Lower physical activity is associated with a higher diabetes risk (18%) compared to the higher activity levels (14%). BMI (p-value=0.00) and random blood sugar level (p-value=0.03) is associated with physical activity. Conclusion: Most of the participants were not involved in moderate physical activity. People who participated in physical activities are at a lower risk of developing diabetes and hypertension. In general, physical activity aids in mitigating harmful chronic diseases.

COVID-19 has greatly affected various aspects of societies worldwide, including the mental health and quality of education for students. Different studies investigated the consequences of the pandemic, but only a few studies have addressed the negative psychological and educational impacts of Corona Virus Anxiety (CVA). This study addresses the effects of CVA on Chinese students and explores university perceptions of its consequences. A mixed-methods research design was used, with 440 university students selected through convenience sampling. The researchers used the CVA scale, generalized anxiety scale, mental health questionnaire, and a self-report scale to assess the students' educational attainment. In addition, 14 students were interviewed for the qualitative phase of the study. Data from the quantitative phase were analyzed using Pearson correlation and descriptive statistics, while content analysis techniques were employed for analyzing the qualitative data. Results showed that CVA is negatively associated with students' anxiety, stress, and depression. Furthermore, stress, anxiety, depression, and CVA were found to be negatively associated with students' GPAs. Qualitative findings revealed that CVA negatively affected students' GPAs, research projects, classroom engagement, and graduations. The findings are theoretically and practically important to universities, schools, and educational centers to avoid the effects of the CVA on students' educational attainment and mental health through appropriate planning and providing facilities to the students during the lockdown.

Although a range of studies has explored the effects of the content and language integrated learning (CLIL) approach on students’ achievement, its impact on improving university students’ transversal skills (TSs) has remained largely unexplored in Iran. Thus, the present study has a two-fold purpose. First, it aims to investigate the role of the CLIL approach in improving Iranian university students’ TSs. Second, it purports to explore the mediating role of emotional intelligence (EI) in the relationship between the CLIL approach and TSs. For this purpose, a survey design was used wherein a research-made questionnaire was distributed among 123 university students to gather the required data. Findings disclosed that the CLIL approach had a positive role in developing the university students’ TSs. Further, the results indicated that EI positively affected the development of TSs in university students. Moreover, the findings evidenced that EI significantly mediated the relationship between the CLIL approach and the development of the university students’ TSs. The study concludes that applying the CLIL approach involves an entirely new paradigm, offering valuable implications for relevant stakeholders.

It has become essential to create and apply new media in visual communication design due to social media existence. This study aims to investigate the role of innovative applications of new media in visual communication design in educational institutions. Traditional media design in visual communication lacks to disseminate information more effectively, which requires innovative change. Therefore, this study attempts to highlight the role of innovative application of new media in visual communication by considering visual expression design with information technology (IT), flexible layout, diversified modes of transmission, and interactivity of integration. For this purpose, this study adopted a quantitative research approach in which a cross-sectional research design is followed. A questionnaire survey is carried out to collect data from educational institutions in China. Partial Least Square-Structural Equation Modeling (PLS-SEM) is used for data analysis. Results of the study indicated that innovative applications of new media have central importance in visual communication. However, resistance to innovative change has a negative role in the relationship between innovative applications of new media and visual communication design. Results of the study highlighted that visual expression design with IT, flexible layout, diversified modes of transmission, and interactivity of integration have a positive effect on visual communication design. Therefore, among the educational intuitions of China, implementing innovative applications related to the new media can lead to visual communication design. The results of this study provided several insights for the practitioners to promote communication methods among educational institutions.

Social media channels are interactive channels that let users spread content, participate, and generate positive or negative news. In this era of social media (SM), organizations run structured and systematic campaigns to shape their corporate images. The present study examines the role of social consciousness (SC) of employees, entertainment (Ent), and altruism (Alt) on unverified news sharing (UVN) with the mediation of corporate image (CI) and the moderation of workplace stress (WS). We conducted the study on 375 employees of the social media teams in the corporate sector in China. The sampling technique used in this study is convenience sampling. We carried out data analysis using structural equation modeling (SEM) with the help of Smart PLS (Partial Least Square) software. The results reveal that the entertainment and altruism of employees affect UVN. However, the direct negative effect of social consciousness of employees and CI on UVN came out to be insignificant. The findings also show that CI mediates the relationship between the social consciousness (SC) of employees and UVN, altruism and UVN, and entertainment and UVN. The moderating role of WS between CI and UVN is significant. Theoretically, the study contributes to the literature by examining the effect of different determinants of UVN on SM on the role of CI and WS. Practically, the present study provides implications for the managers and the organizations. The study finds that Alt is an essential factor that fosters UVN and CI; therefore, altruistic values of the employees should be instigated to reduce the flow of UVN.

Music education is frequently growing around the globe and needs emotional attachments and adoption innovation for the attractive music education that needs researcher’s emphasis. Thus, the current article investigates the impact of lack of emotional experience and resistance to innovation on unattractive music education in China. The current research also investigates the mediating impact of dissatisfied musicians among the association of lack of emotional experience, resistance to innovation, and unattractive music education in China. The study has used the primary data collected using questionnaires. The current article examines the validity and reliability using the measurement assessment model and also tests the hypotheses using the structural assessment model with the help of smart-PLS. The results indicated that the lack of emotional experience and resistance to innovation has a positive and significant impact on unattractive music education in China. The findings also revealed that dissatisfied musicians significantly mediate among lack of emotional experience, resistance to innovation, and unattractive music education in China. This article helps policymakers establish policies about making music education attractive for musicians by adopting innovation.

Recently, uncreative music products have become a global issue due to the unhappy musicians and resistance to innovation that needs researchers’ focus. This article explores the impact of unhappy musicians and resistance to innovation on uncreative music products in Malaysia. This article also investigates the moderating role of psychological security among the relationships of unhappy musicians, resistance to innovation, and uncreative music products in Malaysia. This study has applied the questionnaire method to gather the primary data from the selected respondents. The researchers have also applied the smart-PLS to check the nexus among constructs and test the hypotheses. The results revealed that unhappy musicians and resistance to innovation have a significant and positive linkage with uncreative music products in Malaysia. The results also revealed that psychological security significantly moderates the linkage among unhappy musicians, resistance to innovation, and uncreative music products in Malaysia. Thus, this study guides the regulators to develop the regulations to reduce the unhappiness among musicians and motivates the regulators to adopt innovation to increase the creative music product in Malaysia.

In this global village, easy access to news has resulted in many changes in the preferences and patterns of people for accessing news. Therefore, the present study has attempted to investigate the effects of news relevance, perceived quality, and news overloading on people’s news curation preferences. This study has also examined the mediating role of news avoidance between the news relevance, perceived quality, and news overloading on the news curation. A quantitative technique has been employed to check the relationships proposed in the study. A sample size of 217 has been analyzed to check these hypotheses. The findings of the study revealed that news relevance has a negative impact while news overload positively and significantly impact the news curation. However, the news avoidance only mediated the relationship of news quality and news curation. Theoretically, the study has contributed to the literature of journalism and social media by finding that relevance of news has a negative significant impact on the news curation behavior of people, such that if they do not find the news relevant, they happily curate it. Practically, the study implies that the people are more prone to the quality of news rather than quantity; therefore, it is important for the news agencies to ensure that they produce and deliver the quality based news considering the accuracy to penetrate the Theoretic lass level.

BACKGROUND AND OBJECTIVES: Hepatitis C virus (HCV) is considered a hepatotropic virus, but it can replicate in peripheral blood mononuclear cells (PBMCs), which influence the sustained virological response (SVR) of the patients, as well as relapse in successfully treated patients. The main objective of this study was to establish the importance of PBMC HCV RNA detection as a primary test to declare the patient as a responder, and the secondary objective was to investigate the risk of non-SVR or relapse in individuals who showed an end-of-treatment (ETR). DESIGN AND SETTINGS: Blood samples were collected after the completion of 6 months of therapy, and they were collected 6 months after the completion of treatment. PATIENTS AND METHODS: A total 103 patients infected with the 3a genotype of HCV and those who were treated with interferon-α-2b and ribavirin for 24 weeks were selected. HCV RNA in plasma of at the end of treatment and 6 months after the completion of treatment was determined with the help of quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: Of the 103 patients, 74.8% (number [n]=77) were end-of-treatment responders, while 25.2% (n=26) were nonresponders. Seventy-seven responders were tested for HCV RNA in their PBMCs. The HCV RNA was detected in the PBMCs of 29 patients (37.7%). After 6 months of the end of treatment, 15 (19.5%) of 77 ETR patients showed virological relapse, while 62 (80.5%) patients attained SVR. Relapse appeared significantly more often in patients with HCV RNA in their PBMCs at the ETR stage when compared to the patients who did not have the viral RNA (34.5% versus 10.4%, respectively; R2=6.67, P=.01; odds ratio [OR]: 1.3; 95% confidence interval [CI]=1.032–1.811). CONCLUSION: Patients with HCV RNA in their PBMCs after attaining an ETR are more likely to show relapse as compared to patients who are negative for viral RNA in PBMCs at the ETR stage.

VGF (non-acronymic)is a secreted chromogranin/secretogranin that gives rise to a number of bioactive peptides by a complex proteolysis mechanism. VGF-derived peptides exert an extensive array of biological effects in energy metabolism, mood regulation, pain, gastric secretion function, reproduction and, perhaps, cancer. It is therefore surprising that very little is known about receptors and binding partners of VGF-derived peptides and their downstream molecular mechanisms of action. Here, using affinity chromatography and mass spectrometry-based protein identification, we have identified the heat shock cognate 71 kDa protein A8 (HSPA8)as a binding partner of human TLQP-21 on the surface of human neuroblastomaSH-SY5Y cells. Binding of TLQP-21 to membrane associated HSPA8 in live SH-SY5Y cells was further supported by cross-linking to live cells. Interaction between HSPA8 and TLQP-21 was confirmed in vitro by label-free Dynamic Mass Redistribution (DMR) studies. Furthermore, molecular modeling studies show that TLQP-21 can be docked into the HSPA8 peptide binding pocket. Identification of HSPA8 as a cell surface binding partner of TLQP-21 opens new avenues to explore the molecular mechanisms of its physiological actions, and of pharmacological modulation thereof.

The present study was conducted at Poultry Research Institute, Rawalpindi (Pakistan) with the objective of evaluating egg quality, proximate composition and cholesterol content of eggs and meat in Fayoumi (FAY) and commercial (Nick chick) White Leghorn (WLH) breeds of chickens. For this purpose, 64 adult (40 weeks-old) laying hens, 32 each of FAY and WLH breeds were maintained on littered floor in two separate pens under optimal management conditions. The birds were fed ad libitum a balanced layers ration. They had free access to clean and fresh drinking water and were kept under 16 h daily lighting schedule. Egg quality parameters, proximate composition and cholesterol content of eggs were studied for 6 weeks by randomly collecting 3 eggs daily from each breed. Thigh and breast meat samples were obtained from randomly selecting two birds from each breed by slaughtering them at the termination of experiment for determination of proximate composition and cholesterol content. The results show significantly higher egg weight, albumen weight and moisture content in WLH eggs in comparison to FAY eggs, whereas significantly higher yolk, ether extract content and yolk: albumen ratio were observed in FAY. Non-significant differences in shell weight, shell thickness, crude protein, ash and cholesterol contents were recorded between breeds. Breed differences in ether extract content both in breast and thigh meat and in cholesterol content in thigh portion were significant (p

This study was designed to assess the effect of Centratherum anthelminticum seeds administration on blood and serum risk factor markers in type 2 diabetic (T2D) patients using metformin. It was a randomized non-blinded, controlled, 3month trial. T2D patients were registered from Sindh Government Hospital New Karachi, Karachi. There were 3 groups, DT (Diabetic Test, n=20), DC (Diabetic Control, n=20) HC (Healthy Control n=20, healthy individuals of similar age were selected). DC (metformin 500mg), DT (capsule of C. anthelminticum seeds powder CAPca + metformin 500mg each) and HC (CAPca 500mg) were given daily. Fasting blood glucose, body weights were monitored weekly while blood samples were collected on first and final day of the trial for biochemistry. Administration of CAPca showed significant decrease in % glycaemia (p<0.0001) and % Hb glycosylation (p<0.05) values. Serum risk factor markers including direct bilirubin & uric acid (p<0.01), creatine kinase & alanine aminotransferase (p<0.0001) and creatinine (p<0.05) were reduced significantly. CAPca administration improved blood and serum markers in healthy volunteers too. These improved blood & serum markers in T2D patients indorsed synergistic effect of CAPca with metformin to manage secondary challenges of T2D. [ABSTRACT FROM AUTHOR]