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Paraneoplastic neurologic syndromes are cancer-associated, immune-mediated neurologic manifestations that may involve any part of the nervous system. They usually present with characteristic neurologic features and should be considered in high-risk phenotypes such as limbic encephalitis, encephalomyelitis, rapidly progressive cerebellar syndrome, opsoclonus–myoclonus, sensory neuronopathy, enteric neuropathy, and Lambert–Eaton myasthenic syndrome. The diagnosis is made by antibody positivity in the serum or cerebrospinal fluid, in the presence of an appropriate clinical phenotype. Findings on antibody testing by immunoblot should always be verified by immunofluorescence. We report a rare case of sensory neuronopathy with triple paraneoplastic antibody positivity (anti-Hu, anti-collapsing response-mediator protein 5, and anti-amphiphysin) on immunoblot but only anti-Hu positivity on immunofluorescence. The presence of lower facial dyskinesias should raise the possibility of an immune-mediated neurologic syndrome in the appropriate clinical context.

Abstract Background Anaemia is a significant public health concern in Bangladesh, yet data on the prevalence of anaemia in pregnancy and the contribution of iron deficiency are limited. Given the reliance on groundwater for drinking, a better understanding of the role of drinking water iron in anaemia aetiology is also required to inform anaemia prevention strategies. Methods This cross-sectional study enrolled 1500 pregnant women from Narayanganj district, Bangladesh, during their second or third trimester. Anaemia and iron status were described and their relationship with drinking water iron assessed using regression analyses. Results The prevalence of anaemia was 38% (95% confidence interval, CI: 35%, 40%), with 10% (95% CI: 9%, 12%) experiencing moderate-to-severe anaemia. Iron deficiency affected 48% (95% CI: 45%, 50%) of participants. Although drinking water iron concentrations were generally low (median: 0 mg/L; interquartile range: 0–1), high concentrations (≥ 2 mg/L) were associated with increased ferritin levels but did not significantly impact iron deficiency (95% CI: 0·73, 1·02) or anaemia (95% CI: 0·79, 1·17) prevalence. Iron deficient women had a 1·86 (95% CI: 1·61, 2·15) adjusted prevalence ratio for anaemia and a 4·22 (95% CI: 2·89, 6·17) adjusted prevalence ratio for moderate-to-severe anaemia, compared to iron replete women. Conclusions Anaemia and iron deficiency are highly prevalent among pregnant women in Narayanganj. These findings challenge the assumption of low iron deficiency prevalence throughout Bangladesh and highlight iron deficiency in pregnancy as a potentially underrecognized public health problem, particularly in regions with low drinking water iron. Further research is needed to clarify the contribution of drinking water iron to iron deficiency and anaemia in Bangladesh. Trial registration The study is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12621000982819, registered 26/07/2021)

Introduction: Prostate cancer is one of the most prevalent malignancies affecting men globally, with a significant impact on health-related quality of life (HRQOL). With the recent therapeutic advancements and improvements in survival, there is a need to understand the determinants of HRQOL in metastatic prostate cancer patients to optimize treatment strategies for quality of life as the number of survivors increases. The aim of this study was to identify clinical variables that affect HRQOL and its domains in patients with metastatic prostate cancer. Methods: We conducted a cross-sectional questionnaire-based study in patients diagnosed with metastatic prostate cancer at a tertiary cancer center in India. Baseline clinical features, treatment details, and completed Functional Assessment of Cancer Therapy—Prostate (FACT-P), composed of FACT-general (FACT-G) and prostate cancer-specific concerns subscale (PCS) and FACT-P Trial Outcome Index (FACT-P TOI) questionnaires, were collected. The mean total, as well as individual domain scores, were calculated. Additionally, these were stratified by the current treatment being received by patients. Linear regression was used to identify independent factors affecting HRQOL in these patients. Results: Of the 106 enrolled patients, 84 completed the FACT-P questionnaire and were included in the analysis. The median age was 66 years, and at the time of assessment, 3 patients (3.6%) were receiving androgen deprivation therapy only, 53 patients (63.1%) were on ADT + androgen receptor-targeted agents (ARTAs), and 18 patients (21.4%) patients received ADT + chemotherapy. The mean (±standard deviation) of the FACT-P TOI score was 70.33 (±15.16); the PCS subscale was the most affected, followed by functional well-being. Patients on chemotherapy scored significantly higher on PCS, but the composite scores were not significantly different. Univariable regression identified obesity (body mass index > 25 kg/m2) and duration of first-line treatment as significant predictors of better HRQOL; however, obesity was the only independent predictor in multivariable analysis (β = 8.2; 95% confidence interval, 1.2 to 15.0; p = 0.022). Obesity also independently predicted a better FACT-P and its physical well-being domain score and PCS. Conclusion: Prostate cancer patients experience impaired QoL, especially in the prostate cancer-specific and functional well-being domains. Lower BMI is an independent predictor of poor QoL, and this requires efforts to assess the impact of strategies to manage the nutritional status of patients with metastatic disease on QoL outcomes.

Histiocytic disorders mostly occur as de-novo nodal or extranodal benign masses with rare secondary malignant transformation. A 10-year-old female presented with 10-cm cervical swelling since 9 months associated with fever. Computed tomography revealed left cervical lymphadenopathy and bilateral lung nodules. Lymph node excision biopsy showed effacement of architecture by atypical histiocytes with marked nuclear pleomorphism and frequent mitosis. Focal areas showed mature histiocytes with emperipolesis. The cells were immunopositive for CD68, CD163, and S100 (focal), whereas they were negative for Langerin and CD1a. The Ki67 proliferative index was 30%. A diagnosis of histiocytic sarcoma in a background of Rosai-Dorfman disease was made.

Agro-based small and medium enterprises (SMEs) are currently receiving top priority among policymakers of the South Asian Association for Regional Cooperation (SAARC) nations due to their great contribution to employment and GDP growth. This study examines the impact of financial literacy on the sustainable competitive performance of agro-based SMEs, with a focus on the mediating role of access to digital finance and the moderating role of business experience. Using Partial Least Squares Structural Equation Modelling (PLS-SEM), we analysed data from 345 SME owner-managers. The results indicate that financial literacy positively affects sustainable competitive performance, with access to digital finance serving as a significant mediator. However, business experience does not moderate the relationship between financial literacy and access to digital finance. These findings suggest that improving financial literacy and enhancing digital finance access are critical for the sustainable development of agro-based SMEs in the SAARC region.

This study investigates the performance of different groups of binary liquid mixtures for various aliphatic hydrocarbons of both polar and non-polar types. This highlights the importance of selecting appropriate models based on the specific composition of the mixture for accurate predictions in industrial processes and product optimization. For this purpose, well-known equations of Grunberg-Nissan, Hind, Heric, Ausländer, McAllister 3- body and McAllister 4- body are utilized and tested for the viscosity data of different binary liquid systems, collected from previous research. The systems consist of various aliphatic alkanes, cycloalkanes, and alkanols. They are classified into four groups: Group A (Aliphatic Alkane + Alkane), Group B (Aliphatic Alkane + Cycloalkane), Group C (Aliphatic Alkane + Alkanol) and Group D (Aliphatic Cycloalkane + Alkanol). In order to measure the fitting capabilities for every group of systems, Standard Percentage Deviations (SPD) as well as temperature Average Standard Percentage Deviations (ASPD) for all of the systems are estimated. For both dynamic and kinematic viscosity correlations, among four categories, the best results are found for Group A (Aliphatic Alkanes + Aliphatic Alkanes), followed by Group B (Aliphatic Alkanes + Cycloalkanes), with the poorest results for Group C (Aliphatic Alkanes + Alkanols). In addition, with the increment of the chain length of the systems, a linear change in deviation is also observed.

Background: & Purpose: In the rapidly evolving digital landscape, digital human resource (HR) practices in small and medium-sized enterprises (SMEs) have become a vital success factor. This study adopts the resource-based view of the firm to explore the complicated relationships among digital HR practices, digital transformation, innovative work behavior, disruptive innovation, and work productivity in the context of Chinese SMEs. Methods: This study provides fundamental insights by drawing data from Jiangsu province, China. Data from 339 managerial staff members were collected and analyzed using SmartPLS (4.0) with a partial least squares structural equation model (PLS-SEM). Several measures, model fit, and hypothesis tests were conducted. Findings: Digital HR practices significantly affect digital transformation, innovative work behavior, and productivity. Furthermore, digital transformation is a powerful driver that positively influences innovative work behavior and productivity in SMEs. Interestingly, innovative work behavior positively influenced work productivity, exemplifying the vital role of inspired thinking and problem-solving abilities. This study also investigates the moderating role of disruptive innovation, highlighting its influence on the association between digital HR practices and digital transformation. However, disruptive innovation does not significantly moderate the association between digital transformation and innovative work behavior, suggesting fascinating nuances for SMEs. Conclusion/value: This research extends our understanding of the interaction between digitalization, HR, and innovation, and proposes practical implications for SMEs aiming to harness the transformative potential of digitization. Several theoretical and practical implications are developed for future studies on related SMEs.

Abstract Pain-insomnia-depression syndrome (PIDS) is a complex triad of chronic pain, insomnia, and depression that has profound effects on an individual's quality of life and mental health. The pathobiological context of PIDS involves complex neurobiological and physiological mechanisms, including alterations in neurotransmitter systems and impaired pain processing pathways. The first-line therapeutic approaches for the treatment of chronic pain, depression, and insomnia are a combination of pharmacological and non-pharmacological therapies. In cases where patients do not respond adequately to these treatments, additional interventions such as deep brain stimulation (DBS) may be required. Despite advances in understanding and treatment, there are still gaps in knowledge that need to be addressed. To improve our understanding, future research should focus on conducting longitudinal studies to uncover temporal associations, identify biomarkers and genetic markers associated with PIDS, examine the influence of psychosocial factors on treatment responses, and develop innovative interventions that address the complex nature of PIDS. The aim of this study is to provide a comprehensive overview of these components and to discuss their underlying pathobiological relationships.

Abstract The COVID-19 pandemic has had far-reaching consequences worldwide and has also led to significant changes in people’s lifestyles, resulting in an increase in social problems, such as early marriages for girls in different contexts. This study aimed to examine the relationship between the COVID-19 pandemic and early marriage among girls. Our analysis of 36 studies published between 2020 and 2023 shows that the pandemic has accelerated the number of early marriages for girls in several ways. In many countries, early marriages often result from social disintegration, loss of social support, inability to pay for basic needs, prolonged school closures, economic collapse, and parental death due to COVID-19. Although people in different contexts have different opinions about early marriages for girls due to COVID-19, there is evidence that early marriages for girls are sometimes seen as a solution to ease the financial burden and reduce stress for parents. However, there was a significant decline in traditional marriages in developed countries during the COVID-19 pandemic, including the United States, Mexico, Japan, Korea, and Indonesia. Early marriage can have serious consequences for young adolescents, including mental health problems, such as depression, anxiety, low self-esteem, and feelings of powerlessness. Mixed results, such as an increase or decrease in early marriage among girls, indicate a need for detailed contextual empirical research. It is known that actions are being taken to reduce the prevalence of early marriages, especially in developing countries, but certain situations may accelerate or reverse trends in girls’ early marriages because of various social, economic, and cultural influences. This study suggests further consideration of strategic planning for emergencies, such as the COVID-19 pandemic, that people may face again in the future. Therefore, it is necessary to implement appropriate support for abused and mistreated girls by raising awareness to reduce the psychological and physiological consequences of early marriage due to the pandemic in the near past.

Abstract Background Pakistan reports a significant burden of neonatal mortality, with infections as one of the major causes. We aim to assess the long-term impact of early infancy infections on neurodevelopmental outcomes during later childhood. Methods We conducted a prospective follow-up study of the cohort enrolled at the Karachi site of the Aetiology of Neonatal Infection in South Asia (ANISA) during 2019–2020. Children with a possible serious bacterial infection (based on the WHO IMCI algorithm) at early infancy were assessed for neurodevelopment at 6–9 years of age and compared with healthy controls. The Ten Questions (TQS) questionnaire, Strengths and Difficulties Questionnaire (SDQ), and Parent’s Evaluation of Developmental Stage Assessment Level (PEDS: DM-AL) neurodevelopmental assessment tools, were administered and scored by the research staff who were blinded to the child’s exposure status. Generalized Structural Equation Modelling (GSEM) was employed to verify relationships and associations among developmental milestones, anthropometry, and sociodemographic variables. Results A total of 398 children (241 cases and 157 controls) completed neurodevelopmental and growth assessments. Cases had a significantly higher rate of abnormal TQS scores (54.5% vs. 35.0%, p-value 0.001), greater delays in motor milestones (21.2% vs. 12.1%, p-value 0.02), lower fine motor skills (78.4 ± 1.4 vs. 83.2 ± 1.5, p-value 0.02). The receptive language skills were well-developed in both groups. According to the logistic regression model, exposure to infection during the first 59 days of life was associated with delayed TQS milestones (β = -0.6, 95% CI -1.2,-0.04), TQS hearing domain (β = -0.3, 95% CI: -1.2 to 0.7), PEDS: DM-AL fine motor domain (β = -1.3, 95% CI: -4.4 to 1.7), PEDS: DM-AL receptive language development (β = -1.1, 95% CI: -3.7 to 1.4) and child anthropometric measurements such as weight and height (β = -0.2, 95% CI: -0.4 to 0.01 and β = -0.2, 95% CI: -0.4 to -0.01, respectively). Early pSBI exposure was positively associated with PEDS: DM-AL self-help domain (β = 0.6, 95% CI: -1.2 to 2.4) and SDQ-P overall score (β = 0.02, 95% CI: -0.3 to 0.3). Conclusion Children exposed to PSBI during early infancy have higher rates of abnormal development, motor delays, and lower fine motor skills during later childhood in Pakistan. Socioeconomic challenges and limited healthcare access contribute to these challenges, highlighting the need for long-term follow-ups with integrated neurodevelopment assessments.

Biosolids and Dairy Shed Effluent (DSE) can contain high concentrations of plant nutrients, making them potential resources for enhancing forest tree species growth and soil fertility. This study aimed to investigate the effects of biosolids and DSE application on the growth and nutrient uptake of Leptospermum scoparium and Kunzea robusta, while also considering the potential accumulation of contaminants. The results demonstrated that amending low-fertility soil with 2600 kg N ha-1 of biosolids and 200 kg N ha-1 of DSE positively influenced the growth of both L. scoparium and K. robusta. This improvement was evident through increased biomass production and enhanced uptake of essential elements such as calcium (Ca), potassium (K), and sulfur (S). Notably, L. scoparium exhibited superior growth when combined with DSE, while both species showed similar positive responses when combined with biosolids. However, it should be noted that the application of biosolids resulted in elevated concentrations of certain trace elements in the plants, whereas DSE did not. These trace elements included cadmium (Cd), copper (Cu), manganese (Mn), and zinc (Zn). Despite the increase, the levels of these elements did not exceed unacceptable thresholds. Considering the potential influence of biosolids on plant rhizodeposition, it is recommended that future studies investigate the interactions between plant roots and microbes, particularly in relation to plant element uptake. This line of research would further enhance our understanding of the underlying mechanisms involved. In conclusion, the findings suggest that the application of biosolids and DSE can effectively improve forest tree growth and nutrient uptake. However, careful management is necessary to mitigate the potential accumulation of trace elements. These results provide valuable insights for optimizing the use of biosolids and DSE in forestry practices, with potential economic and environmental benefits.

Sylhet division is the major tea-producing region of Bangladesh. This study was conducted to explore the potential of rainwater harvesting by a designed model to fulfill the water requirement of the Lackatoorah tea garden during the dry season. Data were collected from both primary and secondary sources, and remote sensing data were analyzed using ArcGIS 10.7 to assess soil texture and slope. Four potential sites of (1.5 m ×1m) area were identified to estimate the volume of runoff water in the study. Four tanks with a capacity of 4000 liters were placed to store water as a reservoir for four sites. This study reveals that the study area received maximum average rainfall during June (742.7 mm - 839.2 mm) and July (667.7 mm - 787.2 mm) and the months from October-March received minimum rainfall (

Abstract Background Pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae) has become a potential pest of cotton by causing substantial yield losses around the world including Pakistan. Keeping in view the facts like limited research investigations, unavailability, and high cost of artificial diet’s constituents and their premixes, the present research investigations on the dietary aspect of P. gossypiella were conducted. The larvae of P. gossypiella were reared on different diets that were prepared using indigenous elements. The standard/laboratory diet comprised of wheat germ meal 34.5 g, casein 30.0 g, agar–agar 20.0 g, sucrose 10.0 g, brewer’s yeast 5.0 g, α-cellulose 1.0 g, potassium-sorbate1.5 g, niplagin 0.5 g, decavitamin 0.01 g, choline-chloride 0.06 g, maize-oil 3.30 g, honey 2.0 g, and water 730.0 mL. Alternatives to cotton bolls and wheat germ meal were okra seed sprouts, okra fruit, cottonseed meal, and okra seed meals, which were included in the study to introduce an efficient and economic mass-rearing system. Results The larval development completed in 19.68 d ± 0.05 d with a weight of 20.18 mg ± 0.20 mg at the fourth instar fed on the cottonseed meal-based diet instead of wheat germ meal based diet. On the same diet, 84.00% ± 4.00%, 17.24 mg ± 0.03 mg, and 7.76 d ± 0.06 d were recorded as pupae formation, pupal weight, and pupal duration, respectively. Adult emergence, 76.00% ± 1.00% was recorded from pupae collected from larvae raised on cottonseed meal-based diet. These male and female moths lived for 40.25 d ± 0.10 d, and 44.34 d ± 0.11 d, respectively. Females deposited 21.28 ± 0.04 eggs per day with the viability of 65.78% ± 0.14%. The larval mortality at the fourth instar was 37.20% ± 1.36% and malformed pupation of 12.00% ± 1.41% was recorded. Replacement of wheat germ meal with that of local meals (cottonseed and okra seed) in the standard laboratory diet has saved 463.80 to 467.10 PKR with 1.62 to 1.63 cost economic returns, respectively. Conclusion This research is of novel nature as it provides a concise and workable system for the economic and successful rearing of P. gossypiella under laboratory conditions.

Inflammation is one of the pertinent responses of the body, depending mainly on the process and factors involved in combating the oxidative species produced either by any infection or failure of the antioxidant pathways. In search of new compounds to exhibit antioxidant and anti-inflammatory activity here, we have successfully reported the synthesis of three novel compounds of Piperidin-4-one skeleton by adopting simple and convenient methods. Compound 1, (3, 3-dimethyl-2, 6-bis(3,4,5-trimethoxyphenyl) piperidin-4-one) was synthesized by one-pot Mannich condensation reaction having good yield (88 %). Furthermore in the next step highly functionalized imine derivatives, Compound 2 (3,3-dimethyl-2,6-bis (3,4,5-trimethoxyphenyl) piperidine-4-one) hydrazine carbothioamide) and Compound 3 (3,3-dimethyl-2,6-bis(3,4,5-trimethoxyphenyl) piperidin-4-one oxime) were prepared by the condensation reaction with thiosemicarbazide and hydroxylamine hydrochloride with compound 1, respectively. The structure of the compounds has been deduced by the combined use of modern spectroscopic and single crystal x-ray diffraction (XRD) techniques. in-silico ADMET studies predict pharmacokinetic properties and showed that compounds are non toxic on vital organs. The optimized geometry and reactivity parameters of compounds were further calculated based on the B3LYP/6-31G (d, p) density functional theory (DFT). The negative values of chemical potential follow the trend as 2 (−0.2101) > 3 (−0.2198) > 1(-0.2233) signifies that all compounds are reactive in nature as evident from in-vitro antioxidant and anti-inflammatory response were determined by using the DDPH assay and protein denaturation methods respectively. Compounds possess good radical scavenging activity having IC 50 values 30.392 μM (2), 37.802 (1) μM, and 72.285 (3) μM, and anti-inflammatory response in same manner indicating that 2 (71.3 %) is more active than compound 1 (43.5 %) and 3 (39.3 %) marking them as a potential antioxidant and anti-inflammatory agents.

Chicken (Gallus domesticus) is a significant source of animal protein for the people of Bangladesh. However, anthropogenic activity may contaminate chicken meat with potentially toxic elements (PTEs) despite the nutritional benefits. Current work aims to determine the accumulated content of PTEs (Pb, Cd, Cr, As, and Hg) in chickens and poultry feeds commercially sold in Bangladesh markets and compare with WHO, FAO, EU, EC, FSANZ standards. Three different chicken varieties, native (local variety, freehand raised), poultry (raised for meat only), and layer chicken (commercially raised for eggs and later used for meat), were investigated, and commercial poultry feeds were used to raise the latter two varieties. The Pb, Cd, Cr, As, and Hg contents (mg kg–1 fresh weight (f.w.) were 0.481–1.067, 0.025–0.118, 0.069–0.319, 0.007–0.071, 0.002–0.019, respectively. In addition, associated health risks due to the PTEs in different varieties of chicken organs, e.g., meat, liver, and kidney, were evaluated. The study suggests that the poultry feeds should be carefully monitored regarding PTEs content to avoid potential human health risks due to chicken consumption in Bangladesh.

The consideration of students’ emotional and psychological health is crucial to facilitate effective teaching and grading practices. This study set out to shed light on the interplay between self-esteem (S-E), cognitive-emotion regulation (CER), academic enjoyment (AE), and language success (LS) in artificial intelligence (AI)-supported online language learning. To this end, the foreign language learning self-esteem scale, the Cognitive Emotion Control Questionnaire, the foreign language enjoyment scale, and a researcher-made test were distributed to 389 English as a foreign language learners in China. Screening the data with confirmatory factor analysis and structural equation modeling, the effects of S-E, CER, AE, and LS were identified and quantified. These results highlighted the important function that online courses assisted by AI perform in enhancing students’ CER and AE. This implied that students who have cultivated a robust sense of self-efficacy are adept at effectively regulating their cognitive and affective processes in AI-supported language learning. Possible improvements in language education are discussed, as are the study’s broader implications.

Various industries polluting the water bodies by discharging untreated wastewater directly into the environment and conventional wastewater treatments are often insufficient for effectively treating the pollutants. However, membrane bioreactors (MBRs) offer a promising solution for wastewater treatment where membrane serving as the heart of the system. In this study, polyethersulfone (PES) was used as the membrane material and hydrophilicity of the membranes were tuned up by mixing with hydrophilic additives such as polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) and the membranes have shown promising results in treating wastewater, particularly in terms of chemical oxygen demand (COD), biochemical oxygen demand (BOD), and color removal. For example, PES-PEG membrane demonstrated COD, BOD, and color removal of 96 %, 94 %, and 92 %, respectively while those were 95 %, 94 %, and 92 %, respectively for PES-based commercial membrane. Although the performances of fabricated membranes were comparable to that of commercial membrane in COD, BOD, and color removal efficiencies, there is room for improvement in permeate yields. Notably, the average permeate efficiency for MBR modules produced with PES-3PEG and PES-5PVP membranes was recorded as 47 % (18 L/m2h) and 13 % (5 L/m2h) respectively of the commercial membrane (38 L/m2h). Despite the variance in permeate yields, the fabricated membranes also showcased significant efficacy in removing microorganisms, a crucial aspect of wastewater treatment. Their performance in this regard proved highly comparable to that of the commercial membrane, emphasizing the potential of these fabricated membranes in enhancing the wastewater treatment.

Background and aim: N-acetyl-p-benzoquinoneimine (NAPQI), a toxic byproduct of paracetamol (Acetaminophen, APAP), can accumulate and cause liver damage by depleting glutathione and forming protein adducts in the mitochondria. These adducts disrupt the respiratory chain, increasing superoxide production and reducing ATP. The goal of this study was to provide computational proof that succinate dehydrogenase (SDH), a subunit of complex II in the mitochondrial respiratory chain, is a favorable binding partner for NAPQI in this regard. Method: Molecular docking, molecular dynamics simulation, protein-protein interaction networks (PPI), and KEGG metabolic pathway analysis were employed to identify binding characteristics, interaction partners, and their associations with metabolic pathways. A lipid membrane was added to the experimental apparatus to mimic the natural cellular environment of SDH. This modification made it possible to develop a context for investigating the role and interactions of SDH within a cellular ecosystem that was more realistic and biologically relevant. Result: The molecular binding affinity score for APAP and NAPQI with SDH was predicted −6.5 and −6.7 kcal/mol, respectively. Furthermore, RMSD, RMSF, and Rog from the molecular dynamics simulations study revealed that NAPQI has slightly higher stability and compactness compared to APAP at 100 ns timeframe with mitochondrial SDH. Conclusion: This study serves to predict the mechanistic process of paracetamol toxicity by using different computational approaches. In addition, this study will provide information about the drug target against APAP hepatotoxicity.

MFCs (Microbial Fuel Cell) are bio-electrochemical devices that use microorganisms as biocatalysts to transform the chemical energy found in organic or inorganic compounds into electric currents. However, one of the limitations of this technology in terms of practical application is its lower electric efficiency, which greatly depends on the selection of anode material and the types of waste water used. In this work, organically rich wastewater and pure magnesium anode materials were utilized. Also, to investigate the effect of electrode size on power generation, five different sizes of coin-shaped anodes were employed for the variation in anode size, whose diameter and thickness were (15 mm × 2 mm), (20 mm × 2 mm), (20 mm × 3 mm), (20 mm × 4 mm), and (25 mm × 2 mm) with corresponding surface areas [2πr(r+h)] are 448 mm 2, 754 mm 2, 817 mm 2, 880 mm 2 and 1139 mm 2, respectively. The maximum obtained current density, power density, and energy densities were 4734.26 mA/m2, 37400.625 mW/m2 and 81.59 kW-h/kg respectively, by the smallest anode of size (15 mm × 2 mm). This investigation showed that a reduction in the size of the anode decreases the loss in the activation zone. As a result, from the smallest anode, maximum power and energy output were obtained. Finally, this analysis outlines the process and approaches for MFC to produce more power at a potentially lower cost. It is noted that same waste water has been used throughout the study where surface area of the samples vary from lowest to highest level.

BackgroundApproximately 20%-25% of patients with metastatic castration-resistant prostate cancer (mCRPC) harbor a deleterious germline or somatic mutation in the homologous recombination repair (HRR) pathway genes, which is involved in the repair of double-stranded DNA damage. Half of these mutations are germline, while the remaining are exclusively somatic. While polyadenosine 5’diphosphoribose [poly (ADP-ribose)] polymerase inhibitors, such as olaparib and rucaparib, are effective in this subgroup, their widespread use is limited due to the associated high cost, especially in resource-constrained settings. Notably, platinum agents like carboplatin have exquisite sensitivity to cells with defective DNA repair machinery. Carboplatin, a conventional, inexpensive chemotherapeutic agent, offers a potential alternative treatment in such patients. Several retrospective small case series support this hypothesis. However, there are no prospective clinical trials of carboplatin in patients with mCRPC with HRR mutations. ObjectiveThe primary objective is to assess the objective response rate of 3 weekly carboplatin treatments in patients with mCRPC harboring deleterious mutations in the HRR pathway genes and previously treated with a taxane or a novel antiandrogen agent. The secondary objectives include progression-free survival, health-related quality of life, and safety profile of carboplatin. MethodsPatients diagnosed with mCRPC harboring HRR pathway mutations previously treated with docetaxel or novel antiandrogen agents (abiraterone, enzalutamide, apalutamide, or darolutamide) or both will be eligible. Genes involved directly or indirectly in the HRR pathway will be tested. In this single-arm phase II study, we will screen approximately 200 patients to enroll 49 patients, and carboplatin (dosing at the area under curve=5) will be administered every 3 weeks until progression or intolerable side effects. The primary end point will be assessed as the proportion of patients with a reduction of serum prostate-specific antigen by more than 50% from enrollment. Secondary outcomes include progression-free survival—soft-tissue disease progression (by response evaluation criteria in solid tumors, version 1.1, and bone lesion progression using Prostate Cancer Clinical Trials Working Group 3 criteria), health-related quality of life during carboplatin treatment using the Functional Assessment of Cancer Therapy—Prostate questionnaire and the European Organisation for Research and Treatment of Cancer questionnaire and safety profile of carboplatin (National Cancer Institute’s Common Terminology Criteria for Adverse Events version 5.0). ResultsThe trial started enrollment in September 2023. This trial is ongoing, and 12 patients have been recruited to date. All 49 participants will be enrolled according to plan. ConclusionsThis prospective phase II trial represents a critical step toward addressing the therapeutic gap in patients with mCRPC harboring HRR pathway mutations, particularly in demographic regions with limited access to poly (ADP-ribose) polymerase inhibitors. Outcomes from this study will inform clinical practice and guide future phase III randomized trials, ultimately improving patient outcomes globally. Trial RegistrationClinical Trials Registry of India CTRI/2023/04/051507; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=Njc0NjU=&Enc=&userName= International Registered Report Identifier (IRRID)DERR1-10.2196/54086

Abstract Multi‐walled carbon nanotubes (MWCNTs) were successfully synthesized and functionalized by chemical vapour deposition and acid reflux methods, respectively. Chitosan (CTS) was prepared by a chemical extraction method from waste prawn shells. Various weight fractions of functionalized multi‐walled carbon nanotubes (f‐MWCNTs) have been used as reinforcing agent in CTS biopolymer matrix. Fourier transform infrared spectroscopy analysis was done, which confirms the presence of absorption bands of the various functional groups of chitin, CTS, and MWCNTs. Raman spectra revealed the quality of MWCNTs, the extent of their functionalization, and the quality of nanocomposites. The X‐ray diffraction analysis showed the distinctive peaks for f‐MWCNTs’ and also revealed the formation of CTS/f‐MWCNTs nanocomposites. Transmission Electron Microscopy (TEM) analysis also exhibited that the CTS/f‐MWCNTs nanoparticles have a well‐defined crystalline structure. The highest coercivity and magnetization (Ms) of the CTS/5%f‐MWCNTs nanocomposite are 602 Oe and 0.1202 emu/g, respectively that have been enhanced by 3.83 and 5.27 times compared to the pure CTS respectively. It showed that the conductivity is getting higher with the addition of f‐MWCNTs in the CTS matrix. CTS/5% f‐MWCNTs composites exhibit the highest conductivity than other composites and the conductivity of CTS/5% f‐MWCNTs composite is 4.0×10−4 S/m.

In order to systematically investigate the correlating capability of viscosity models, six well-known correlative models of Grunberg-Nissan (GN), Hind (HND), Heric (HRC), Ausländer (AUS) for dynamic viscosity, η, and McAllister 3-body (MAC3) and McAllister 4-body (MAC4) for kinematic viscosity, ν, were employed and tested for viscosity data of 83 organic binary liquid systems consisting of 33 different aromatic hydrocarbons (ArH), alkanes (RH), cycloalkanes (CyRH) and alkanols (ROH). Keeping ArH as a common component and increasing the chain length of other components, the systems were categorized as Category 1: ArH + RH, Category 2: ArH + CyRH, Category 3: ArH + ArH and Category 4: ArH + ROH. For all the models fitting parameters along with the statistical parameters such as SPD σ(%), ASPD σ(%), OASPD σ(%) and GOASPD σ(%) were computed by the Nonlinear Least Squares Minimization (NLSM) technique with the ‘Solver’ add-in package. Among the four categories, Category 3, OASPD, σ(%) values lie between 0.16 and 0.21, indicating that all the models fitted extremely well. However, for dynamic viscosities, the η AUS model demonstrated the best correlating capabilities with GOASPD σ(%) of 0.48, while the HND model performed the poorest with GOASPD σ(%) at 3.8. For the kinematic viscosities, ν in both the MAC3 and MAC4 models yielded satisfactory results with GOASPD σ(%) as < 1.0 %.

Background:Intrauterine growth restriction (IUGR) and preeclampsia (PE) are intricately linked with specific maternal health conditions, exhibit shared placental abnormalities, and play pivotal roles in precipitating preterm birth (PTB) incidences. However, the molecular mechanism underlying the association between PE and IUGR has not been determined. Therefore, we aimed to analyze the data of females with PE and those with PE + IUGR to identify the key gene(s), their molecular pathways, and potential therapeutic interactions.Methods:In this study, a comprehensive relationship analysis of both PE and PE + IUGR was conducted using RNA sequence datasets. Using two datasets (GSE148241 and GSE114691), differential gene expression analysis via DESeq2 through R-programming was performed. Gene set enrichment analysis was performed using ClusterProfiler, protein‒protein interaction (PPI) networks were constructed, and cluster analyses were conducted using String and MCODE in Cytoscape. Functional enrichment analyses of the resulting subnetworks were performed using ClueGO software. The hub genes were identified under both conditions using the CytoHubba method. Finally, the most common hub protein was docked against a library of bioactive flavonoids and PTB drugs using the PyRx AutoDock tool, followed by molecular dynamic (MD) simulation analysis. Pharmacokinetic analysis was performed to determine the ADMET properties of the compounds using pkCSM.Results:We identified eight hub genes highly expressed in the case of PE, namely, PTGS2, ENG, KIT, MME, CGA, GAPDH, GPX3, and P4HA1, and the network of the PE + IUGR gene set demonstrated that nine hub genes were overexpressed, namely, PTGS2, FGF7, FGF10, IL10, SPP1, MPO, THBS1, CYBB, and PF4. PTGS2 was the most common hub gene found under both conditions (PE and PEIUGR). Moreover, the greater (−9.1 kcal/mol) molecular binding of flavoxate to PTGS2 was found to have satisfactory pharmacokinetic properties compared with those of other compounds. The flavoxate-bound PTGS2 protein complex remained stable throughout the simulation; with a ligand fit to protein, i.e., a RMSD ranging from ∼2.0 to 4.0 Å and a RMSF ranging from ∼0.5 to 2.9 Å, was observed throughout the 100 ns analysis.Conclusion:The findings of this study may be useful for treating PE and IUGR in the management of PTB.

ABSTRACTThe envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing antibodies. Broadly neutralizing antibodies (bnAbs) that target gp120 V3-glycan of HIV-1 Env trimer are potent and block the entry of diverse HIV-1 strains. Most V3-glycan bnAbs interact, to a different extent, with a glycan attached to N332, but Asn at this position is not absolutely conserved or required for HIV-1 entry based on the prevalence of N332 in different circulating HIV-1 strains from diverse clades. Here, we studied the effects of amino acid changes at position 332 of HIV-1AD8 Envs on HIV-1 sensitivity to antibodies, cold exposure, and soluble CD4. We further investigated how these changes affect Env function and HIV-1 infectivity in vitro. Our results suggest robust tolerability of HIV-1AD8 Env N332 to changes, with specific changes that resulted in extended exposure of gp120 V3 loop, which is typically concealed in most primary HIV-1 isolates. Viral evolution leading to Asn at position 332 of HIVAD8 Envs is supported by the selection advantage of high levels of cell–cell fusion, transmission, and infectivity with high levels of cell surface expression and slightly higher gp120 shedding than most N332 variants. Thus, tolerance of HIV-1AD8 Envs to different amino acids at position 332 provides increased flexibility to respond to changing conditions/environments and evade the immune system. Modeling studies of the distance between N332 glycan and specific bnAbs were in agreement with N332 glycan dependency on bnAb neutralization. Overall, our studies provide insights into the contribution of specific amino acids at position 332 to Env antigenicity, stability on ice, and conformational states.IMPORTANCEGlycan attached to amino acid asparagine at position 332 of HIV-1 envelope glycoproteins is a main target of a subset of broadly neutralizing antibodies that block HIV-1 infection. Here, we defined the contribution of different amino acids at this position to Env antigenicity, stability on ice, and conformational states.

Soil parameters are crucial aspects in increasing agricultural production. Even though Bangladesh is heavily dependent on agriculture, little research has been done regarding its automation. And a vital aspect of agricultural automation is predicting soil parameters. Generally, sensors relating to soil parameters are quite expensive and are often done in a controlled environment such as a greenhouse. However, a large scale implementation of such expensive sensors is not very feasible. This work tries to find an inexpensive solution towards predicting soil parameters such as soil moisture and temperature, both of which are crucial to the growth of crops. We focus on finding a robust relation between the above mentioned soil parameters with the nearby weather parameters such as humidity and temperature, irrespective of the weather. We apply different machine learning models like multilayer perceptron (MLP), random forest, etc. to predict the soil parameters, given the humidity and temperature of the surrounding environment. For all the experiments we have used a custom made dataset, which contains around 9000 datapoints of soil moisture & temperature, ambient humidity & temperature. The data has been collected in an uncontrolled agriculture bed via inexpensive sensors. Our results show that XGBoost regressor achieves the best results with an R2 score of 0.93 and 0.99 for soil moisture and soil temperature data respectively. This suggests very high correlation between the weather parameters and soil parameters. The model also portrayed a very low root mean squared error and mean absolute error of 0.037 & 0.015 for soil moisture and 0.001 & 0.0008 for soil temperature. Our results show that it is indeed possible to find the soil parameters from the corresponding weather, which will have great impact on mass agricultural automation. The dataset has been made publicly available at https://github.com/Nadimulhaque0403/Soil_parameter_prediction_dataset.

A 35-year-old individual with carpal tunnel syndrome presented with tingling and numbness in the left thumb, index, and middle finger. A 3D printed CTS splint was crafted to immobilize the affected wrist joint, aiding pharmacotherapy. At six weeks, evaluations included the Boston Carpal Tunnel Questionnaire (BCTQ), Visual Analogue Scale (VAS) for pain, and Evaluation of Satisfaction with assistive Technology (QUEST) version 2.0.9. Substantial improvements were observed in Bangla-BCTQ scores (symptom severity scale: 3.68 vs. 1.27; functional status scale: 2.74 vs. 1.31), VAS (70 vs. 30), and QUEST scores. 3D printing technology may contribute to better personalized musculoskeletal care enhancing quality of life.

Abstract Acne vulgaris (AV) is a psychosomatic disorder and can negatively affect individuals, especially in terms of psychological well-being, self-esteem, and quality of life (QoL). The current study aimed to investigate the association between AV and psychological health, as well as the influence of acne and psychological distress in predicting patients' self-esteem and QoL. This cross-sectional study included 150 patients clinically diagnosed with AV. The severity of acne was measured using GAGS, and following that, patients were instructed to complete the following forms: DASS-21, RSES, CADI, DLQI, and WHOQoL. Female AV patients had significantly higher depression (p = 0.003, t = 3.025) and anxiety (p

Abstract Consequential validity, a facet of construct validity, has been extensively explored by educational psychologists and scholars focused on English language assessment. It is widely recognized that English language instructors must possess a thorough understanding of high-stake language tests. However, the body of research concerning EFL teachers’ perceptions of high-stake tests is quite limited. This study aims to delve into the cognitions of Iranian EFL teachers regarding the social and psychological ramifications of high-stake English language tests. Additionally, the study investigates the influence of a teacher training workshop on EFL teachers’ perceptions of test consequences. The research employs a two-phase quantitative research design. A total of 210 EFL teachers participated in the survey, completing a scale comprising 25 items that delineated their perceptions of test consequences. Furthermore, thirty teachers engaged in a two-session workshop focused on test consequences. Data analysis encompassed both one-sample and paired-sample t tests. The results reveal that EFL teachers possess knowledge regarding certain social and psychological consequences of language tests; however, their awareness of some adverse consequences remains limited. Notably, the outcomes indicate that teacher training workshops have a positive impact on teachers’ cognitions of both positive and negative test consequences. The implications of these findings extend to teacher trainers and English language educators, offering practical insights to enhance the effectiveness of their teaching practices.

Abstract Purpose Anorexia nervosa (AN) is a neuropsychological public health concern with a socially disabling routine and affects a person’s healthy relationship with food. The role of the NNAT (Neuronatin) gene in AN is well established. The impact of mutation at the protein’s post-translational modification (PTM) site has been exclusively associated with the worsening of the protein’s biochemical dynamics. Methods To understand the relationship between genotype and phenotype, it is essential to investigate the appropriate molecular stability of protein required for proper biological functioning. In this regard, we investigated the PTM-acetylation site of the NNAT gene in terms of 19 other specific amino acid probabilities in place of wild type (WT) through various in silico algorithms. Based on the highest pathogenic impact computed through the consensus classifier tool, we generated 3 residue-specific (K59D, P, W) structurally modified 3D models of NNAT. These models were further tested through the AutoDock Vina tool to compute the molecular drug binding affinities and inhibition constant (Ki) of structural variants and WT 3D models. Results With trained in silico machine learning algorithms and consensus classifier; the three structural modifications (K59D, P, W), which were also the most deleterious substitution at the acetylation site of the NNAT gene, showed the highest structural destabilization and decreased molecular flexibility. The validation and quality assessment of the 3D model of these structural modifications and WT were performed. They were further docked with drugs used to manage AN, it was found that the ΔGbind (kcal/mol) values and the inhibition constants (Ki) were relatively lower in structurally modified models as compared to WT. Conclusion We concluded that any future structural variation(s) at the PTM-acetylation site of the NNAT gene due to possible mutational consequences, will serve as a basis to explore its relationship with the propensity of developing AN. Level of evidence No level of evidence—open access bioinformatics research.

Abstract An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bnAbs) against HIV-1 envelope glycoproteins (Envs) to block viral entry is still not available. Thus, identifying triggers for elicitation of different types of anti-HIV-1 Env antibodies by vaccination could provide further guidance for immunogen design and vaccine development. Here, we studied the immune response to HIV-1 Env immunogens in rabbits. We show that sequential immunizations with conformation-specific Env immunogens can elicit low titer but broad neutralization responses against heterologous, neutralization-resistant (tier 2/3) transmitted/founder (T/F) HIV-1 strains. More importantly, an mRNA vaccine candidate that could mediate the presentation of a cytoplasmic tail-deleted (ΔCT) HIV-1AD8 Env immunogen on virus-like particles significantly increased the neutralization response. This strategy shifted the type of elicited antibodies, decreasing the level of binding to soluble Envs while significantly increasing their overall viral neutralization activity. The breadth and potency of neutralizing response against heterologous, T/F HIV-1 strains significantly increased in a subset of rabbits. Efficient neutralization activity was associated with high cellular immune responses specific to HIV-1 Envs. These results help to understand the immune response to different immunization schemes and will allow developing new approaches to selectively manipulate the type of humoral immune response by specific vaccination.

Abstract Background Liver transplantation, the last treatment for advanced liver failure, necessitates patient education due to its wide range of complications and subsequent disabilities. The present study was development-applied research and aimed to design a mobile-based educational program to provide liver transplant patients with critical health information. Methods In the first phase of the study, the crucial educational components were collected from the literature and organized in the form of a questionnaire using library studies and available global guidelines. The validity and reliability of this researcher-made questionnaire were confirmed by a panel of experts (n = 15), including gastroenterologists and liver specialists working in the Motahari liver clinic and AbuAli Sina Hospital in Shiraz. The application was designed followed by analyzing the data gathered from the first phase. To evaluate the mobile phone program’s usability, to evaluate the application, 30 liver transplant patients were randomly selected. Results Most educational components covered in the questionnaire were deemed necessary by experts in the first phase. As a result, the educational contents were classified under 10 categories. The application had a good level of usability since the participants’ satisfaction score was 8.1 (out of 9 points). Conclusions Due to the increase in liver transplantation and the use of mobile phones, applications increase the patient’s role in their health, and their awareness. It also leads to a better interaction and follow-up of the patient, the treatment staff of the medical centers.

Abstract Synovial sarcoma (SS) is one of the commonest non-rhabdomyosarcoma soft tissue sarcoma with limited treatment options in the relapsed and advanced settings. The combination of gemcitabine and docetaxel has demonstrated its role predominantly in leiomyosarcoma and pleomorphic sarcomas but has not been prospectively studied in SS. This trial assesses the efficacy, tolerability and quality of life (QoL) with this regimen in metastatic/unresectable locally advanced relapsed SS. Patients and methods This was a single-arm, two-stage, phase II, investigator-initiated interventional study among patients with metastatic or unresectable locally advanced SS who had progressed after at least one line of chemotherapy. Gemcitabine 900 mg/m2 on days 1 and 8 and docetaxel 75 mg/m2 on day 8 were administered intravenously every 21 days. The primary endpoint was 3-month progression-free rate (PFR); overall survival (OS), progression-free survival (PFS), overall response rate (ORR), safety and quality of life (QoL) constituted the secondary endpoints. Results Twenty-two patients were enrolled between March 2020 and September 2021 and the study had to be closed early due to slow accrual. The study population comprised of 18 (81.8%) patients with metastatic disease and 4 (18.2%) patients with locally advanced, unresectable disease. The most common primary sites of disease were extremity in 15 (68%) and the median number of lines of prior therapies received was 1 (range 1–4). 3-month PFR was 45.4% (95% CI 24.8–66.1) and ORR was 4.5%. Median progression-free survival (PFS) was 3 months (95% CI 2.3–3.6) and median OS was 14 months (95% CI 8.9–19.0). 7 (31.8%) patients experienced grade 3 or worse toxicities, including anemia (18%), neutropenia (9%) and mucositis (9%). QoL analysis demonstrated significant decline in certain functional and symptom scales, while financial and global health scales remained stable. Conclusion This is the first prospective study on the combination of gemcitabine and docetaxel performed specifically in patients with advanced, relapsed SS. Although the accrual of patients could not be completed as planned, the therapy did produce clinically meaningful outcomes and met its primary endpoint of 3-month PFR. This result, along with the manageable toxicity profile and stable global health status on QoL analysis, should encourage further studies. Trial registration This trial was prospectively registered under the Clinical Trials Registry of India on 26/02/2020 (Registration number: CTRI/2020/02/023612).

The ‘Learning Meta-Learning’ dataset presented in this paper contains both categorical and continuous data of adult learners for 7 meta-learning parameters: age, gender, degree of illusion of competence, sleep duration, chronotype, experience of the imposter phenomenon, and multiple intelligences. Convenience sampling and Simple Random Sampling methods are used to structure the anonymous online survey data collection voluntarily for LML dataset creation. The responses from the 54 survey questionnaires contain raw data from 1021 current students from 11 universities in Bangladesh. The entire dataset is stored in an excel file and the entire questionnaire is accessible at (10.5281/zenodo.8112213)In this article mean and standard deviation for the participant's baseline attributes are given for scale parameters, and frequency and percentage are calculated for categorical parameters. Academic curriculum, courses as well as professional training materials can be reviewed and redesigned with a focus on the diversity of learners. How the designed courses will be learned by learners along with how they will be taught is a significant point for education in any discipline. As the survey questionnaires are set for adult learners and only current university students have participated in this survey, this dataset is appropriate for study andragogy and heutagogy but not pedagogy.

(1) Shigella spp. (Shigella) is known for causing dysentery with blood in stool, but most children infected with Shigella have non-dysentery Shigella-associated diarrhea (NDSD). The World Health Organization recommends the use of antibiotics when diarrhea is bloody, leaving most NDSD cases untreated. The absence of dysentery may not indicate a low risk of death and severe morbidity. Rapid diagnosis and treatment of shigellosis in vulnerable, young children may be lifesaving. INSIGHT aims to determine the potential benefit of identifying NDSD cases (n = 296) and their outcomes compared to cases of Shigella dysentery [DS (n = 148)] and non-Shigella watery diarrhea [WD (n = 148)]. (2) Children seeking care at hospitals in Bangladesh will be enrolled and followed for 1 year (NDSD and DS) or 90 days (WD). We will determine the impact of NDSD on morbidity, mortality, gut health, nutritional status, and cognitive development compared to DS and WD in children and whether the simple “Rapid LAMP-based Diagnostic Test (RLDT)” can accelerate the detection and treatment of shigellosis in the clinical settings of rural Bangladesh. (3) INSIGHT will determine the impact of NDSD in children and determine if the treatment guidelines of shigellosis need to be revisited to improve clinical outcomes and the development of these children.

Introduction Central nervous system (CNS) tumors account for around 1 to 2% of all neoplasms, commonest of them being gliomas. Gliomas constitute a large, heterogenous group of tumors known for a wide variation in clinical presentation, gross and microscopic features, and biologic behavior. Squash cytology can be a great asset in the intraoperative diagnosis of CNS pathology. In this article, we correlate it with the histopathology of gliomas.

Abstract Keratins are an integral part of cell structure and function. Here, it is shown that ectopic expression of a truncated isoform of keratin 81 (tKRT81) in breast cancer is upregulated in metastatic lesions compared to primary tumors and patient‐derived circulating tumor cells, and is associated with more aggressive subtypes. tKRT81 physically interacts with keratin 18 (KRT18) and leads to changes in the cytosolic keratin intermediate filament network and desmosomal plaque formation. These structural changes are associated with a softer, more elastically deformable cancer cell with enhanced adhesion and clustering ability leading to greater in vivo lung metastatic burden. This work describes a novel biomechanical mechanism by which tKRT81 promotes metastasis, highlighting the importance of the biophysical characteristics of tumor cells.

Internet of things (IoT) and software-defined networking (SDN) are two relatively recent developments in the field of communication technology that have emerged in response to the growing demand for more efficient, flexible, and dynamic network architectures. As both of these concepts are new, they have received increasing attention from academic or industrial sources to emphasize their potential for integration. This study is aimed at reviewing the literature on SDN for IoT (SDN-IoT) published from 2014 to 2022 and presenting insights and directions for future research, with a particular focus on cloud, fog, and edge computing. The study collects data from Science Direct, IEEE Explore, and Google Scholar and objectively selects 126 papers and conducts metadata analysis. The study articulates the challenges of managing and orchestrating IoT systems and how SDN can be used to address these challenges by enabling dynamic and flexible network configurations. It delineates not only the function of blockchain (BC) technology in securing and managing IoT networks but also how SDN can be utilized to incorporate BC-based solutions. Additionally, the potential of SDN for mobile networks is explored, which are increasingly being used to support IoT devices. Finally, this study outlines the issues, challenges, and potential future research directions that may present opportunities for the researchers working in this field, underscoring the demand for more in-depth investigation and advancement.

Objective: Regular physical activity is beneficial to both physical and emotional well-being. The present study goal is to observe how lack of physical exercise leads to various noncommunicable diseases. Methodology:A study was conducted at Central Park Housing Society, Lahore using cross sectional study design. Data was collected from 250 residents of Lahore, Pakistan’s Central Park Housing Society using the structured tool IPAQ-LF. Structured tool used in this study was applicable on age group between 15-69 years, therefore we included participants aged between 15-69 years in this study. While children, adolescences having age between 10-14 years, adults > 69 years old, pregnant women and those with existing non- communicable diseases were excluded from the study. The Kruskal-Wallis ANOVA test was used to determine whether there was a significant relationship between physical activity and non-communicable diseases. Results: About 20.8% participants had family history of hypertension. Greater physical activity is linked to reduce hypertension risk. Lower physical activity is associated with a higher diabetes risk (18%) compared to the higher activity levels (14%). BMI (p-value=0.00) and random blood sugar level (p-value=0.03) is associated with physical activity. Conclusion: Most of the participants were not involved in moderate physical activity. People who participated in physical activities are at a lower risk of developing diabetes and hypertension. In general, physical activity aids in mitigating harmful chronic diseases.

Saltwater intrusion in the coastal areas of Bangladesh is a prevalent phenomenon. However, it is not conducive to activities such as irrigation, navigation, fish spawning and shelter, and industrial usage. The present study analyzed 45 water samples collected from 15 locations in coastal areas during three seasons: monsoon, pre-monsoon, and post-monsoon. The aim was to comprehend the seasonal variation in physicochemical parameters, including water temperature, pH, electrical conductivity (EC), salinity, total dissolved solids (TDS), hardness, and concentrations of Na+, K+, Mg2+, Ca2+, Fe2+, HCO3-, PO43-, SO42-, and Cl-. Additionally, parameters essential for agriculture, such as soluble sodium percentage (SSP), sodium absorption ratio (SAR), magnesium absorption ratio (MAR), residual sodium carbonate (RSC), Kelly's ratio (KR), and permeability index (PI), were examined. Their respective values were found to be 63%, 16.83 mg/L, 34.92 mg/L, 145.44 mg/L, 1.28 mg/L, and 89.29%. The integrated water quality index was determined using entropy theory and principal component analysis (PCA). The resulting entropy water quality index (EWQI) and SAR of 49.56% and 63%, respectively, indicated that the samples are suitable for drinking but unsuitable for irrigation. These findings can assist policymakers in implementing the Bangladesh Deltaplan-2100, focusing on sustainable land management, fish cultivation, agricultural production, environmental preservation, water resource management, and environmental protection in the deltaic areas of Bangladesh. This research contributes to a deeper understanding of seasonal variations in the hydrochemistry and water quality of coastal rivers, aiding in the comprehension of salinity intrusion origins, mechanisms, and causes.

The present study investigates an environmentally conscious method for synthesizing silver nanoparticles (AgNPs) by employing extracts from pomegranate peel (PgP) and pineapple peel (PnP). This green synthesis approach offers a sustainable alternative to traditional chemical methods, thereby reducing the ecological footprint associated with nanoparticle production. The PgP and PnP extracts serve as both reducing and capping agents during the synthesis process, enhancing the biocompatibility of the resultant AgNPs. Various characterization techniques, including UV-Vis spectroscopy, Raman analysis, X-ray diffraction (XRD), dynamic light scattering (DLS), Fourier transform infrared (FTIR), and transmission electron microscopy (TEM), were utilized to analyze the synthesized AgNPs. UV-Vis spectroscopy confirmed the formation of AgNPs through characteristic surface plasmon resonance peaks, while FTIR examined the interaction between biomaterial components and the oxidation and coating of silver nanoparticles. Raman analysis elucidated the functional groups responsible for reducing and stabilizing AgNPs, while XRD provided insights into their crystalline structure. TEM images revealed the size and morphology of the nanoparticles, while DLS characterized their average size and morphology. In addition, the synthesized AgNPs were utilized in a bioelectrochemical cell to leverage their unique properties for enhanced electrochemical performance, showcasing their potential application in energy storage and conversion systems. Overall, this study demonstrates the feasibility of utilizing agricultural waste products such as PgP and PnP for sustainable AgNP synthesis, offering promising prospects for environmentally friendly nanotechnology advancement.

Abstract In this investigation, a nanostructured Cu2O thin film absorber layer is electrodeposited, exploring the impact of varying negative applied voltages and deposition time. Notably, the Cu2O thin film demonstrated optimal absorbance at −0.95 V, contrasting sharply with a minimum at −0.97 V. The authors' findings underscore that the peak absorbance was achieved at −0.95 V, coinciding with the lowest transmittance observed after 80 min of deposition, aligning with a maximal absorption coefficient of 21 × 103 cm−1. At a deposition time of 5 min, the Cu2O thin film exhibited a noteworthy maximum Urbach energy of 2.00 eV and a minimum steepness parameter of 0.013. In contrast, the lowest Urbach energy was recorded at 0.34 eV, with the highest steepness parameter occurring at an applied voltage of 0.93 V. Furthermore, this study revealed a gradual increase in the refractive index with higher applied voltages, reaching its pinnacle at −1.5 V. These results collectively emphasize the nuanced interplay between applied voltage, deposition time and the optical properties of the nanostructured Cu2O thin film. The observed trends hold significant implications for optimizing the performance of thin film absorber layers, particularly in the context of enhancing absorbance and tailoring optical characteristics for specific applications.

In this research paper, our primary objective is centered around the creation, characterization, and evaluation of zinc sulfate (ZnSO4) nanoparticles through the utilization of Nigella sativa as a natural reducing agent. We embraced an environmentally conscious and uncomplicated green synthesis approach to synthesize these ZnSO4 nanoparticles. For a comprehensive examination of their structural and physical properties, we employed techniques such as x-ray diffraction, Raman spectroscopy, scanning electron microscopy, and dynamic light scattering analysis. Our results unequivocally confirmed the successful production of ZnSO4 nanoparticles with well-defined crystalline structures, distinct wavelength patterns, prominent peak values, and specific particle sizes. This study underscores the impressive efficacy of Zn nanoparticles in the context of bio-electrolyte power generation systems. In addition, it introduces an economically feasible and environmentally friendly method for their fabrication. The Zn nanoparticles display great potential as a solid basis for advancing bio-electrochemical cells, underscoring the significance of further exploration into their effects on these cells.

Objective: Regular physical activity is beneficial to both physical and emotional well-being. The present study goal is to observe how lack of physical exercise leads to various noncommunicable diseases. Methodology:A study was conducted at Central Park Housing Society, Lahore using cross sectional study design. Data was collected from 250 residents of Lahore, Pakistan’s Central Park Housing Society using the structured tool IPAQ-LF. Structured tool used in this study was applicable on age group between 15-69 years, therefore we included participants aged between 15-69 years in this study. While children, adolescences having age between 10-14 years, adults > 69 years old, pregnant women and those with existing non- communicable diseases were excluded from the study. The Kruskal-Wallis ANOVA test was used to determine whether there was a significant relationship between physical activity and non-communicable diseases. Results: About 20.8% participants had family history of hypertension. Greater physical activity is linked to reduce hypertension risk. Lower physical activity is associated with a higher diabetes risk (18%) compared to the higher activity levels (14%). BMI (p-value=0.00) and random blood sugar level (p-value=0.03) is associated with physical activity. Conclusion: Most of the participants were not involved in moderate physical activity. People who participated in physical activities are at a lower risk of developing diabetes and hypertension. In general, physical activity aids in mitigating harmful chronic diseases.

Viruses rely on host cell machinery, an obligation that forces a myriad of interactions between the viral proteins and host cell organelles to create an intracellular environment conducive to viral dissemination. In their pursuit to exploit the cellular organelles and modulate their function, viruses affect the overall physiology of the cell. The consequence of viral infection on host cell physiology largely varies between acute vs chronic infection, cell type infected, and the productive or abortive nature of the infection. Viruses leading to chronic infection favor viral persistence by promoting the viability of infected cells by inducing cellular homeostatic pathways. In contrast, viruses causing an acute infection trigger physiological alterations that often lead to the cytocidal effect.

Pleomorphic myxoid liposarcoma (PML) is a newly recognized entity with aggressive clinical behavior and a tendency to recur. It has histological features of both myxoid and pleomorphic liposarcoma and lacks the molecular and structural chromosomal abnormalities associated with myxoid and pleomorphic liposarcoma. The data about their response to chemotherapy is quite sparse. We report a case of incidentally detected pleomorphic myxoid liposarcoma of the mediastinum in a 32-year-old gentleman. After resection and adjuvant chemotherapy with doxorubicin and ifosfamide, there was no evidence of residual disease at the end of treatment. During a routine follow-up 5 months later, he was found to have a recurrence of the disease with histological confirmation. He received a trabectedin given its activity in myxoid liposarcoma. However, he had toxicities and progression leading to its discontinuation. Subsequently, eribulin was started as the next line of therapy. After 4 cycles of chemotherapy, response assessment was suggestive of partial response, which is still maintained after 7 cycles of eribulin. This is the first report of this entity responding to a newer chemotherapy regimen.

Abstract Obesity is a major risk factor for hypertension, type 2 diabetes and other morbidities. On the other hand, hypertension is a leading cause of cardiovascular disease. The presence of obesity in hypertensive persons increases cardiovascular risk and related mortality. Data on the prevalence of obesity and hypertension in academic staff in Bangladesh are scarce. This study aimed to determine the prevalence and factors associated with obesity and hypertension among university academic staff in Bangladesh. In total, 352 academic staff were enrolled in this study from two universities in Bangladesh. A pre-structured questionnaire was used to obtain data on anthropometric, demographic and lifestyle-related factors. Bivariate and multivariate logistic regression analyses were performed to assess the factors associated with obesity and hypertension. Overall, the prevalence of general and abdominal obesity and hypertension was 26.7%, 46.9% and 33.7%, respectively. Female staff had a significantly higher prevalence of both general and abdominal obesity (41% and 64.1%, respectively) than male staff (21.5% and 34.9%, respectively) (p 50 years and 41–50 years age groups, respectively. According to the regression analysis, female gender and inadequate physical activity were independently associated with general and abdominal obesity. On the other hand, increased age, BMI, WC, presence of diabetes and smoking showed a significant association with hypertension. In conclusion, the prevalence of obesity and hypertension was higher among university academic staff members in Bangladesh. Our findings suggest that comprehensive screening programs are needed to facilitate the diagnosis, control, and prevention of obesity and hypertension in high-risk population groups.

Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing pneumonia in-hospital mortality risk factors. Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identify mortality risk factors. Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumonia case fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%, 95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawing pneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94, 95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI 1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32). Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalized with chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutrition were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry should be integrated in pneumonia hospital care for children under 5 years.

Abstract Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody production. This study aimed to determine the association of human leukocyte antigen (HLA)‐DQ and ‐DR alleles with SLE at a tertiary hospital in Bangladesh. Methods This case–control study was conducted in the Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. The patients who fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE were considered cases (n = 41). The controls (n = 32) were selected from the hospital staff of BSMMU, including doctors and nurses who did not suffer from any known rheumatic diseases, and there was no such disease in their first‐degree relatives. Polymerase chain reaction using a sequence‐specific primer (PCR‐SSP) in a low‐resolution typing method was carried out on blood samples collected for HLA‐DQ and ‐DR allele typing. Results The cases and controls had comparable mean ages (31 vs. 32 years), and most cases were female (95.1% vs. 34.4%). The most frequent clinical manifestations were mucocutaneous (85.4%), followed by musculoskeletal (70.7%) and constitutional symptoms (58.5%). The cases had a significantly higher frequency of HLA‐DR2 allele compared with healthy controls (70.7% vs. 43.8%; odds ratio: 3.1; 95% confidence interval: 1.2–8.2). In addition, HLA‐DQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases (88.9%, P = 0.03). Conclusions Bangladeshi adults having HLA‐DR2 may be more susceptible to SLE. HLA‐DQ6 allele might be associated with mucocutaneous manifestations of SLE.

Neurosarcoidosis (NS) is a protean illness with multiple clinical and radiological presentations giving it the moniker of “a chameleon” or the great mimic. NS can present as a wide spectrum of neurological syndromes localizing both to the central and peripheral nervous systems. The absence of a diagnostic serum test makes it difficult to diagnose with certainty and remains largely a histopathological diagnosis and one of exclusion. A high index of suspicion should be there in suspecting NS, and it should always be excluded among patients presenting with acute to subacute neurological deficits.