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1. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Author

Gault, Abigail, Agnieszka, Michael, Bedair, Ahmed, Ghaus, Aisha, Akingboye, Akinfemi, Maynard, Alec, Pawsey, Alexander, Suwaidan, Ali Abdulnabi, Okines, Alicia, Massey, Alison, Kwan, Amy, Ferreira, Ana, Angelakas, Angelos, Wu, Anjui, Tivey, Ann, Armstrong, Anne, Madhan, Annet, Pillai, Annet, Poon-King, Ashley, Kurec, Bartlomiej, Usborne, Caroline, Dobeson, Caroline, Thirlwell, Christina, Mitchell, Christian, Sng, Christopher, Scrase, Christopher, Jingree, Christopher, Brunner, Clair, Fuller, Claire, Griffin, Clare, Barrington, Craig, Muller, Daniel, Ottaviani, Diego, Gilbert, Duncan, Tacconi, Eliana, Copson, Ellen, Renninson, Emily, Cattell, Emma, Burke, Emma, Smith, Fiona, Holt, Francesca, Soosaipillai, Gehan, Boyce, Hayley, Shaw, Heather, Hollis, Helen, Bowyer, Helen, Anil, Iris, Illingworth, Jack, Gibson, Jack, Bhosle, Jaishree, Best, James, Barrett, Jane, Noble, Jillian, Sacco, Joseph, Chacko, Joseph, Chackathayil, Julia, Banfill, Kathryn, Feeney, Laura, Horsley, Laura, Cammaert, Lauren, Mukherjee, Leena, Eastlake, Leonie, Devereaux, Louise, Melcher, Lucinda, Cook, Lucy, Teng, Mabel, Hewish, Madeleine, Bhattacharyya, Madhumita, Choudhury, Mahbuba, Baxter, Mark, Scott-Brown, Martin, Fittall, Matthew, Tilby, Michael, Rowe, Michael, Alihilali, Mohammed, Galazi, Myria, Yousaf, Nadia, Chopra, Neha, Cox, Nicola, Chan, Olivia, Sheikh, Omar, Ramage, Paul, Greaves, Paul, Leonard, Pauline, Hall, Peter S, Naksukpaiboon, Piangfan, Corrie, Pippa, Peck, Rahul, Sharkey, Rachel, Bolton, Rachel, Sargent, Rebecca, Jyothirmayi, Rema, Goldstein, Robert, Oakes, Roderick, Shotton, Rohan, Kanani, Ruhi, Board, Ruth, Pettengell, Ruth, Claydon, Ryan, Moody, Sam, Massalha, Samah, Kathirgamakarthigeyan, Sangary, Dolly, Saoirse, Derby, Sarah, Lowndes, Sarah, Benafif, Sarah, Eeckelaers, Sarah, Kingdon, Sarah, Ayers, Sarah, Brown, Sean, Ellis, Shawn, Parikh, Shefali, Pugh, Sian, Shamas, Simon, Wyatt, Simon, Grumett, Simon, Lau, Sin, Wong, Yien Ning Sophia, McGrath, Sophie, Cornthwaite, Stephanie, Hibbs, Stephen, Tillet, Tania, Rabbi, Taslima, Robinson, Tim, Roques, Tom, Angelis, Vasileios, Woodcock, Victoria, Brown, Victoria, Peng, YingYing, Drew, Yvette, Hudson, Zoe, Lee, Lennard Y W, Cazier, Jean-Baptiste, Starkey, Thomas, Briggs, Sarah E W, Arnold, Roland, Bisht, Vartika, Booth, Stephen, Campton, Naomi A, Cheng, Vinton W T, Collins, Graham, Curley, Helen M, Earwaker, Philip, Fittall, Matthew W, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin J X, Lee, Rebecca J, Lee, Siow Ming, Mckenzie, Hayley, Middleton, Chris P, Murugaesu, Nirupa, Newsom-Davis, Tom, Olsson-Brown, Anna C, Palles, Claire, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Topping, Oliver, Turnbull, Chris D, Várnai, Csilla, Briggs, Adam D M, Middleton, Gary, and Kerr, Rachel

Published
2020
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2. Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19

Author

Várnai, Csilla, Palles, Claire, Arnold, Roland, Curley, Helen M., Purshouse, Karin, Cheng, Vinton W. T., Booth, Stephen, Campton, Naomi A., Collins, Graham P., Hughes, Daniel J., Kulasekararaj, Austin G., Lee, Alvin J. X., Olsson-brown, Anna C., Sharma-oates, Archana, Van Hemelrijck, Mieke, Lee, Lennard Y. W., Kerr, Rachel, Middleton, Gary, Cazier, Jean-baptiste, Pugh, Sian, Corrie, Pippa, Bedair, Ahmed, Hewish, Madeleine, Leonard, Pauline, Illingworth, Jack, Hibbs, Stephen, Diamantis, Nicolaos, Massalha, Samah, Fuller, Claire, Usbourne, Caroline, Gilbert, Duncan, Davies, Jennifer, Newsom-davis, Tom, Sharkey, Rachel, Lee, Rebecca, Tivey, Ann, Shotton, Rohan, Griffin, Clare, Horsley, Laura, Shamas, Simon, Sacco, Joseph J, Choudhury, Madbuba, Noble, Jillian, Shaw, Heather, Bolton, Rachel, Ferreira, Ana, Hall, Peter, Ramage, Paul, Bhosle, Jaishree, Massey, Alison, Hill, Michaela, Mukherjee, Leena, Ghaus, Aisha, Derby, Sarah, Brown, Sean, Lowndes, Sarah, Dolly, Saorise, Russell, Beth, Moss, Charlotte, Muller, Daniel, Pillai, Annet, Lowe, Shakeel, Cook, Lucy, Scrase, Christopher, Jyothirmayi, Rema, Board, Ruth, Cornthwaite, Stephanie, Parikh, Shefail, Cattell, Emma, Cox, Nicola, Gault, Abigail, Moody, Sam, Dobeson, Caroline, Baxter, Mark, Roques, Tom, Pawsey, Alexander, Oakes, Roderick, Melcher, Lucinda, Chan, Olivia, Ayers, Sarah, Bowyer, Helen, Althohami, Mohammed, Mittal, Sajjan, Feeney, Laura, Aujayeb, Avinash, Sheikh, Omar, Kathirgamakarthigeyan, Sangary, Woodcock, Victoria, Holt, Francesca, Wyatt, Simon, Topping, Oliver, Tilby, Michael, Bhattacharyya, Madhumita, Burke, Emma, Ellis, Shawn, Chacko, Joseph, Rabbi, Taslima, Rowe, Michael, Sargent, Rebecca, Thirlwell, Christina, Gibson, Jack, Goldstein, Robert, Fittall, Mathew, Gennatas, Spyridon, Okines, Alicia, Best, James, Tillett, Tania, Renninson, Emily, Grumett, Simon, Barrington, Craig, Pettengell, Ruth, Peng, Yingyying, Chackathayil, Julia, Akingboye, Akinfemi, Hollis, Helen, Shin Chin, Ik, Bisht, Vartika, Hartley, Simon, Middleton, Christopher P, Goel, Anshita, Protheroe, Emily, Naksukpaiboon, Paingfan, Anil, Iris, Michell, Joel, D'costa, Jamie, Wu, Anjui, Ottaviani, Diego, Soosaipillai, Gehan, Galazi, Myria, Chopra, Neha, Benafif, Sarah, Sng, Christopher Ct, Wong, Sophia Yn, Scott-brown, Martin, Copson, Ellen, Robinson, Timothy, Hudson, Zoe, Smith, Fiona, Abdulnabi Mohamed, Ali-abdulnabi, Angelakas, Angelos, Eastlake, Leoni, Poon-king, Ashley, Brunner, Clair, Kwan, Amy, Maynard, Alec, Boyce, Hayley, Spurrell, Emma, Peck, Rahul, and Kurec, Bartlomiej

Subjects
Aged, 80 and over, Male, Lung Neoplasms, SARS-CoV-2, COVID-19, General Medicine, Middle Aged, United Kingdom, Cohort Studies, Drug Therapy, Hematologic Neoplasms, Humans, Female, Immunotherapy, Prospective Studies, Registries, Aged
Abstract

Importance Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence of the association of recent cancer treatment and cancer type with COVID-19 mortality.Objective To evaluate whether systemic anticancer treatments (SACTs), tumor subtypes, patient demographic characteristics (age and sex), and comorbidities are associated with COVID-19 mortality.Design, Setting, and Participants The UK Coronavirus Cancer Monitoring Project (UKCCMP) is a prospective cohort study conducted at 69 UK cancer hospitals among adult patients (≥18 years) with an active cancer and a clinical diagnosis of COVID-19. Patients registered from March 18 to August 1, 2020, were included in this analysis.Exposures SACT, tumor subtype, patient demographic characteristics (eg, age, sex, body mass index, race and ethnicity, smoking history), and comorbidities were investigated.Main Outcomes and Measures The primary end point was all-cause mortality within the primary hospitalization.Results Overall, 2515 of 2786 patients registered during the study period were included; 1464 (58%) were men; and the median (IQR) age was 72 (62-80) years. The mortality rate was 38% (966 patients). The data suggest an association between higher mortality in patients with hematological malignant neoplasms irrespective of recent SACT, particularly in those with acute leukemias or myelodysplastic syndrome (OR, 2.16; 95% CI, 1.30-3.60) and myeloma or plasmacytoma (OR, 1.53; 95% CI, 1.04-2.26). Lung cancer was also significantly associated with higher COVID-19–related mortality (OR, 1.58; 95% CI, 1.11-2.25). No association between higher mortality and receiving chemotherapy in the 4 weeks before COVID-19 diagnosis was observed after correcting for the crucial confounders of age, sex, and comorbidities. An association between lower mortality and receiving immunotherapy in the 4 weeks before COVID-19 diagnosis was observed (immunotherapy vs no cancer therapy: OR, 0.52; 95% CI, 0.31-0.86).Conclusions and Relevance The findings of this study of patients with active cancer suggest that recent SACT is not associated with inferior outcomes from COVID-19 infection. This has relevance for the care of patients with cancer requiring treatment, particularly in countries experiencing an increase in COVID-19 case numbers. Important differences in outcomes among patients with hematological and lung cancers were observed

Published
2022
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4. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Author

Lee, Lennard Y W, primary, Cazier, Jean-Baptiste, additional, Starkey, Thomas, additional, Briggs, Sarah E W, additional, Arnold, Roland, additional, Bisht, Vartika, additional, Booth, Stephen, additional, Campton, Naomi A, additional, Cheng, Vinton W T, additional, Collins, Graham, additional, Curley, Helen M, additional, Earwaker, Philip, additional, Fittall, Matthew W, additional, Gennatas, Spyridon, additional, Goel, Anshita, additional, Hartley, Simon, additional, Hughes, Daniel J, additional, Kerr, David, additional, Lee, Alvin J X, additional, Lee, Rebecca J, additional, Lee, Siow Ming, additional, Mckenzie, Hayley, additional, Middleton, Chris P, additional, Murugaesu, Nirupa, additional, Newsom-Davis, Tom, additional, Olsson-Brown, Anna C, additional, Palles, Claire, additional, Powles, Thomas, additional, Protheroe, Emily A, additional, Purshouse, Karin, additional, Sharma-Oates, Archana, additional, Sivakumar, Shivan, additional, Smith, Ashley J, additional, Topping, Oliver, additional, Turnbull, Chris D, additional, Várnai, Csilla, additional, Briggs, Adam D M, additional, Middleton, Gary, additional, Kerr, Rachel, additional, Gault, Abigail, additional, Agnieszka, Michael, additional, Bedair, Ahmed, additional, Ghaus, Aisha, additional, Akingboye, Akinfemi, additional, Maynard, Alec, additional, Pawsey, Alexander, additional, Suwaidan, Ali Abdulnabi, additional, Okines, Alicia, additional, Massey, Alison, additional, Kwan, Amy, additional, Ferreira, Ana, additional, Angelakas, Angelos, additional, Wu, Anjui, additional, Tivey, Ann, additional, Armstrong, Anne, additional, Madhan, Annet, additional, Pillai, Annet, additional, Poon-King, Ashley, additional, Kurec, Bartlomiej, additional, Usborne, Caroline, additional, Dobeson, Caroline, additional, Thirlwell, Christina, additional, Mitchell, Christian, additional, Sng, Christopher, additional, Scrase, Christopher, additional, Jingree, Christopher, additional, Brunner, Clair, additional, Fuller, Claire, additional, Griffin, Clare, additional, Barrington, Craig, additional, Muller, Daniel, additional, Ottaviani, Diego, additional, Gilbert, Duncan, additional, Tacconi, Eliana, additional, Copson, Ellen, additional, Renninson, Emily, additional, Cattell, Emma, additional, Burke, Emma, additional, Smith, Fiona, additional, Holt, Francesca, additional, Soosaipillai, Gehan, additional, Boyce, Hayley, additional, Shaw, Heather, additional, Hollis, Helen, additional, Bowyer, Helen, additional, Anil, Iris, additional, Illingworth, Jack, additional, Gibson, Jack, additional, Bhosle, Jaishree, additional, Best, James, additional, Barrett, Jane, additional, Noble, Jillian, additional, Sacco, Joseph, additional, Chacko, Joseph, additional, Chackathayil, Julia, additional, Banfill, Kathryn, additional, Feeney, Laura, additional, Horsley, Laura, additional, Cammaert, Lauren, additional, Mukherjee, Leena, additional, Eastlake, Leonie, additional, Devereaux, Louise, additional, Melcher, Lucinda, additional, Cook, Lucy, additional, Teng, Mabel, additional, Hewish, Madeleine, additional, Bhattacharyya, Madhumita, additional, Choudhury, Mahbuba, additional, Baxter, Mark, additional, Scott-Brown, Martin, additional, Fittall, Matthew, additional, Tilby, Michael, additional, Rowe, Michael, additional, Alihilali, Mohammed, additional, Galazi, Myria, additional, Yousaf, Nadia, additional, Chopra, Neha, additional, Cox, Nicola, additional, Chan, Olivia, additional, Sheikh, Omar, additional, Ramage, Paul, additional, Greaves, Paul, additional, Leonard, Pauline, additional, Hall, Peter S, additional, Naksukpaiboon, Piangfan, additional, Corrie, Pippa, additional, Peck, Rahul, additional, Sharkey, Rachel, additional, Bolton, Rachel, additional, Sargent, Rebecca, additional, Jyothirmayi, Rema, additional, Goldstein, Robert, additional, Oakes, Roderick, additional, Shotton, Rohan, additional, Kanani, Ruhi, additional, Board, Ruth, additional, Pettengell, Ruth, additional, Claydon, Ryan, additional, Moody, Sam, additional, Massalha, Samah, additional, Kathirgamakarthigeyan, Sangary, additional, Dolly, Saoirse, additional, Derby, Sarah, additional, Lowndes, Sarah, additional, Benafif, Sarah, additional, Eeckelaers, Sarah, additional, Kingdon, Sarah, additional, Ayers, Sarah, additional, Brown, Sean, additional, Ellis, Shawn, additional, Parikh, Shefali, additional, Pugh, Sian, additional, Shamas, Simon, additional, Wyatt, Simon, additional, Grumett, Simon, additional, Lau, Sin, additional, Wong, Yien Ning Sophia, additional, McGrath, Sophie, additional, Cornthwaite, Stephanie, additional, Hibbs, Stephen, additional, Tillet, Tania, additional, Rabbi, Taslima, additional, Robinson, Tim, additional, Roques, Tom, additional, Angelis, Vasileios, additional, Woodcock, Victoria, additional, Brown, Victoria, additional, Peng, YingYing, additional, Drew, Yvette, additional, and Hudson, Zoe, additional

Published
2020
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5. Immune checkpoint inhibitors and the orbit; two cases of reactive dacryoadenitis.

Author

Fenech, Matthew, Ajanaku, Ayodeji, Hsuan, James, McCormick, Austin, Shamas, Simon, and Ghadiri, Nima

Subjects
*IMMUNE checkpoint inhibitors, *IMMUNE checkpoint proteins, *LACRIMAL apparatus, *IMMUNOREGULATION, *MONOCLONAL antibodies
Abstract

Immune checkpoints refer to mechanisms entrusted with the modulation of immune responses in peripheral tissues and are required for minimising collateral damage. Immune checkpoint inhibitors (ICPi) work through numerous pathways, including the anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti-PD-1 (programmed cell death protein 1) and the PD-L1 (protein cell death protein-ligand-1) pathways. They are proving to be an exciting therapeutic avenue in the attempt to activate anti-tumour activity. Ipilimumab is a fully human monoclonal antibody working on the anti-CTLA-4 pathway, while nivolumab and pembrolizumab are humanised monoclonal IgG4 antibodies that work on the PD-1 pathway. Despite a growing body of research pertinent to these novel therapies, early indications show that they are limited by their side effect profile. Furthermore, their efficacy appears to be greater in cancers with a high mutational burden. We present two female patients with bilateral reactive dacryoadenitis secondary to ICPi therapy, a finding that to the best of our knowledge was not previously described in the literature. [ABSTRACT FROM AUTHOR]

Published
2024
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