AlEidan,Fahad A S, AlManea,Reem K, AlMoneef,Alyah T, Shalash,Nada A, AlRajhi,Norah A, AlMousa,Sarah F, Al Raizah,Abdulrahman, Abuelgasim,Khadega A, AlEidan,Fahad A S, AlManea,Reem K, AlMoneef,Alyah T, Shalash,Nada A, AlRajhi,Norah A, AlMousa,Sarah F, Al Raizah,Abdulrahman, and Abuelgasim,Khadega A
Fahad A S AlEidan,1,2 Reem K AlManea,2 Alyah T AlMoneef,2 Nada A Shalash,2 Norah A AlRajhi,2 Sarah F AlMousa,2 Abdulrahman Al Raizah,1â 3 Khadega A Abuelgasim1,2 1King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 2College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 3King Abdullah International Medical Research Center, Saudi Society for Bone Marrow Transplant, Ministry of National Guard Health Affairs, Riyadh, Saudi ArabiaCorrespondence: Fahad A S AlEidan, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, Tel +966118011111, Email faleidan@gmail.comBackground: Little is written about recurrence and mortality rates after a first episode of venous thromboembolism (VTE) among Saudi population.Aim: Determine incidence rates and assess predictors of recurrence and mortality following the first VTE event.Patients and Methods: A total of 1124 patients aged ⥠18 years with symptomatic VTE confirmed by imaging tests were evaluated. The incidence of VTE recurrence and mortality were assessed. The association between patient characteristics, and VTE recurrence and mortality was explored by estimating the hazard ratio (HR) and 95% confidence interval (CI). The difference between cancer-related, provoked and unprovoked VTE in terms of recurrence and mortality was explored using KaplanâMeier curves.Results: The annual incidence rate of the first VTE was 1.7 per 1000 patients. Of 1124 patients with first VTE, 214 (19%) developed recurrent VTE, and 192 (17%) died with overall incidence rates of 15.8 per 100 person-years (95% CI, 13.8â 18.0) and 10.0 per 100 person-years (95% CI, 8.7â 11.5). Intensive care unit (ICU) admission (HR, 2.15; 95% CI, 1.67â 3.10), presence of active cancer (HR, 2.97; 95% CI, 1.87â 3.95), immobilization (HR, 2.52; 95% CI, 1.79â 3.67), infection (HR, 2.32; 95% CI, 1.94â 3.45), and pulmonary embolism ± d