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6. Integrated design and application of stimuli-responsive metal–organic frameworks in biomedicine: current status and future perspectives.

Author

Hao Liu, Fei Xing, Peiyun Yu, Shakya, Sujan, Kun Peng, Ming Liu, Zhou Xiang, and Ritz, Ulrike

Abstract

In recent years, metal–organic frameworks (MOFs) have garnered widespread attention due to their distinctive attributes, such as high surface area, tunable properties, biodegradability, extremely low density, high loading capacity, diverse chemical functionalities, thermal stability, well-defined pore sizes, and molecular dimensions. Increasingly, biomedical researchers have turned their focus towards their multifaceted development. Among these, stimuli-responsive MOFs, with their unique advantages, have captured greater interest from researchers. This review will delve into the merits and drawbacks of both endogenous and exogenous stimuli-responsive MOFs, along with their application directions. Furthermore, it will outline the characteristics of different synthesis routes of MOFs, exploring various design schemes and modification strategies and their impacts on the properties of MOF products, as well as how to control them. Additionally, we will survey different types of stimuli-responsive MOFs, discussing the significance of various MOF products reported in biomedical applications. We will categorically summarize different strategies such as anticancer therapy, antibacterial treatment, tissue repair, and biomedical imaging, as well as insights into the development of novel MOFs nanomaterials in the future. Finally, this review will conclude by summarizing the challenges in the development of stimuli-responsive MOFs in the field of biomedicine and providing prospects for future research endeavors. [ABSTRACT FROM AUTHOR]

Published
2024
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12. [Clavicular hook plate with coracoclavicular ligament augmentation by suture anchor in the treatment of unstable distal clavicle fractures]

Author

Shuang, Wu, Jialei, Chen, Jie, Zhang, Shakya, Sujan, Fei, Xing, and Zhou, Xiang

Subjects
Male, Fracture Fixation, Internal, Fractures, Bone, Treatment Outcome, 骨与关节修复重建, Suture Anchors, Ligaments, Articular, Humans, Female, Middle Aged, Bone Plates, Clavicle, Retrospective Studies
Abstract

To evaluate the effectiveness of a clavicular hook plate with coracoclavicular ligament augmentation by suture anchor in the treatment of Neer types Ⅱ and Ⅴ distal clavicle fractures.Between January 2010 and June 2016, 16 patients with Neer types Ⅱ and Ⅴ distal clavicle fractures were treated with clavicle hook plates and coracoclavicular ligament augmentation by suture anchor. There were 12 males and 4 females with an average age of 45.6 years (range, 14-81 years). The injury mechanism included falling in 10 cases, traffic accident injury in 2 cases, falling from height in 2 cases, and heavy object injury in 2 cases. The Neer classification of clavicle fractures included 2 cases of type Ⅱa, 13 cases of type Ⅱb, and 1 case of type Ⅴ. The injury severity score (ISS) was 6-29, with an average of 11.2. The time from injury to operation was 1-18 days, with an average of 6.4 days. The operation time, intraoperative blood loss, hospitalization stay, fracture healing, and postoperative complications were recorded; the disability of arm, shoulder, and hand (DASH) score, the shoulder joint Constant score, and the Oxford shoulder score (OSS) were used to evaluate the shoulder joint at last follow-up.All operations were successfully completed. The operation time was 50-100 minutes, with an average of 75.6 minutes; intraoperative blood loss was 30-100 mL, with an average of 52.8 mL; hospitalization stay was 4-47 days, with an average of 13.7 days. All patients were followed up 1.2-7.5 years, with an average of 3.5 years. All clavicle fractures healed, and the healing time was 9.4-13.6 weeks, with an average of 11.9 weeks. No fracture nonunion, fracture displacement, failure of internal fixation, or incision infection,Clavicular hook plate with coracoclavicular ligament augmentation by suture anchor can help achieve good effectiveness with less postoperative complication in the treatment of Neer types Ⅱ and Ⅴ distal clavicular fractures.探讨锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗 Neer Ⅱ型或Ⅴ型锁骨远端骨折的疗效。.2010 年 1 月—2016 年 6 月使用锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗 16 例 Neer Ⅱ型或Ⅴ型锁骨远端骨折患者。其中男 12 例，女 4 例；年龄 14～81 岁，平均 45.6 岁。致伤原因：摔伤 10 例，交通事故伤 2 例，高处坠落伤 2 例，重物砸伤 2 例。锁骨骨折 Neer 分型：Ⅱa 型 2 例，Ⅱb 型 13 例，Ⅴ型 1 例。损伤严重程度评分（ISS）为 6～29 分，平均 11.2 分。受伤至手术时间为 1～18 d，平均 6.4 d。记录患者手术时间、术中出血量、住院时间、骨折愈合情况和术后并发症；末次随访时采用上肢功能评定表（DASH）评分、肩关节 Constant 评分和牛津肩关节评分（OSS）评价肩关节功能。.所有手术均顺利完成，手术时间 50～100 min，平均 75.6 min；术中出血量 30～100 mL，平均 52.8 mL；住院时间 4～47 d，平均 13.7 d。所有患者均获随访，随访时间 1.2～7.5 年，平均 3.5 年。锁骨骨折均愈合，愈合时间 9.4～13.6 周，平均 11.9 周。无骨折不愈合、骨折移位、内固定失效、切口感染等并发症发生。15 例患者于骨折愈合和功能恢复后取出锁骨钩钢板，1 例因无明显不适拒绝二次手术取出锁骨钩钢板。末次随访时，DASH 评分为 0～13 分，平均 2.2 分；肩关节 Constant 评分为 90～100 分，平均 96.8 分；OSS 评分为 12～14 分，平均 12.3 分。.锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗 Neer Ⅱ型或Ⅴ型锁骨远端骨折可获得较好临床疗效，术后并发症少，是一种治疗不稳定锁骨远端骨折的良好方法。.

Published
2021

15. Integrated design and application of stimuli-responsive metal-organic frameworks in biomedicine: current status and future perspectives.

Author

Liu H, Xing F, Yu P, Shakya S, Peng K, Liu M, Xiang Z, and Ritz U

Subjects
Humans, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Biocompatible Materials chemical synthesis, Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents chemical synthesis, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemical synthesis, Metal-Organic Frameworks chemistry, Metal-Organic Frameworks pharmacology, Metal-Organic Frameworks chemical synthesis
Abstract

In recent years, metal-organic frameworks (MOFs) have garnered widespread attention due to their distinctive attributes, such as high surface area, tunable properties, biodegradability, extremely low density, high loading capacity, diverse chemical functionalities, thermal stability, well-defined pore sizes, and molecular dimensions. Increasingly, biomedical researchers have turned their focus towards their multifaceted development. Among these, stimuli-responsive MOFs, with their unique advantages, have captured greater interest from researchers. This review will delve into the merits and drawbacks of both endogenous and exogenous stimuli-responsive MOFs, along with their application directions. Furthermore, it will outline the characteristics of different synthesis routes of MOFs, exploring various design schemes and modification strategies and their impacts on the properties of MOF products, as well as how to control them. Additionally, we will survey different types of stimuli-responsive MOFs, discussing the significance of various MOF products reported in biomedical applications. We will categorically summarize different strategies such as anticancer therapy, antibacterial treatment, tissue repair, and biomedical imaging, as well as insights into the development of novel MOFs nanomaterials in the future. Finally, this review will conclude by summarizing the challenges in the development of stimuli-responsive MOFs in the field of biomedicine and providing prospects for future research endeavors.

Published
2024
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