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145 results on '"Shakhtshneider, T."'

33. Pressure-induced phase transitions in organic molecular crystals: a combination of x-ray single-crystal and powder diffraction, raman and IR-spectroscopy

Author

Boldyreva, E V, primary, Sowa, H, additional, Ahsbahs, H, additional, Goryainov, S V, additional, Chernyshev, V V, additional, Dmitriev, V P, additional, Seryotkin, Y V, additional, Kolesnik, E N, additional, Shakhtshneider, T P, additional, Ivashevskaya, S N, additional, and Drebushchak, T N, additional

Published
2008
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36. Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides.

Author

SHAKHTSHNEIDER, T. P., MYZ, S. A., BOLDYREVA, E. V., NIZOVSKII, A. I., and KUMAR, RAKESH

Subjects
*BALL mills, *HYDROXIDES, *PIROXICAM, *ANTIARTHRITIC agents, *X-ray photoelectron spectroscopy, *NANOCOMPOSITE materials
Abstract

The composites of piroxicam and meloxicam with gamma-alumina, aluminium hydroxides (gibbsite and boehmite), alpha and gamma polymorphs of iron(III) oxide having different surface area and morphology were prepared by planetary ball-milling. It has been shown that the initial state of the excipient (specific surface area, particle size and morphology) had a pronounced effect on the formation of the core-shell composites with the drugs and their properties. The X-ray diffraction patterns and IR spectra measured for co-milled samples as well as X-ray photoelectron spectroscopy studies gave evidence that the components of the mixtures interacted with each other and became amorphous, as composites were formed. The drug release from the composites was different as compared with pure drugs, meloxicam and piroxicam behaving differently that can be explained by formation of strong or weak bonds with the active sites of the carriers. In the case of mechanocomposites, the drugs dissolved quickly due to high surface of organic phase in the core-shell composites. The high-porous carriers can serve as the sorbents for the drugs in solution. [ABSTRACT FROM AUTHOR]

Published
2014
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40. Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides.

Author

SHAKHTSHNEIDER, T. P., MYZ, S. A., DYAKONOVA, M. A., BOLDYREV, V. V., BOLDYREVA, E. V., NIZOVSKII, A. I., KALINKIN, A. V., and KUMAR, RAKESH

Subjects
*PIROXICAM, *ALUMINUM oxide, *CHEMICAL bonds, *DRUG stability, *MECHANICAL chemistry
Abstract

The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms. It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form. [ABSTRACT FROM AUTHOR]

Published
2011
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49. New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents

Author

Shakhtshneider, T. P., Kuznetsova, S. A., Zamay, A. S., Zamay, T. N., Spivak, E. A., Mikhailenko, M. M., Malyar, Yu. N., Kuznetsov, B. N., Chesnokov, N. V., Boldyrev, V. V., Shakhtshneider, T. P., Kuznetsova, S. A., Zamay, A. S., Zamay, T. N., Spivak, E. A., Mikhailenko, M. M., Malyar, Yu. N., Kuznetsov, B. N., Chesnokov, N. V., and Boldyrev, V. V.

Abstract

Betulin and its esters are the natural compounds with high in vitro cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared to the initial substances without losing the structural integrity and functionality of these compounds. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascite carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin esters derivatives against cancer cells.

50. New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents.

Author

Shakhtshneider TP, Kuznetsova SA, Zamay AS, Zamay TN, Spivak EA, Mikhailenko MA, Malyar YN, Kuznetsov BN, Chesnokov NV, and Boldyrev VV

Subjects
Cell Line, Tumor, Cell Survival drug effects, Drug Screening Assays, Antitumor methods, Esters chemistry, Galactans pharmacology, Humans, Lung Neoplasms drug therapy, Lung Neoplasms pathology, Microscopy, Electron, Scanning, Solubility, Triterpenes pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Galactans chemistry, Triterpenes chemistry
Abstract

Betulin and its esters are the natural compounds with high in vitro cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball-milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared with the initial substances without losing the structural integrity and functionality. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascites carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin ester derivatives against cancer cells.

Published
2016
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