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16. Most cutaneous squamous cell carcinoma recurrences occur in the first 3 years after diagnosis: A multicenter retrospective cohort study.

Author

Granger, Emily E., Ran, Nina A., Groover, Morgan K., Koyfman, Shlomo A., Vidimos, Allison T., Wysong, Ashley, Carr, David R., Shahwan, Kathryn T., Hirotsu, Kelsey E., Carucci, John A., Carter, Joi B., Cañueto, Javier, Girardi, Fabio Muradás, Mangold, Aaron R., Srivastava, Divya, Brodland, David G., Zitelli, John A., Willenbrink, Tyler J., and Ruiz, Emily S.

Published
2024
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17. Standardizing Retrospective Observational Research in Cutaneous Squamous Cell Carcinoma: Expert Panel Guidelines from ITSCC.

Author

Cheraghlou, Shayan, Stevenson, Mary L., Christensen, Sean R., Bordeaux, Jeremy S., Walker, Joanna L., Srivastava, Divya, Ferrándiz-Pulido, Carla, Bibee, Kristin P., Carter, Joi B., Samie, Faramarz H., Patel, Vishal A., Carroll, Bryan T., Vidimos, Allison T., Baum, Christian L., Leitenberger, Justin J., Jambusaria-Pahlajani, Anokhi, Ruiz, Emily S., Carucci, John A., Carr, David R., and Shahwan, Kathryn T.

Published
2024
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27. Cemiplimab for the Treatment of Advanced Cutaneous Squamous Cell Carcinoma: Appropriate Patient Selection and Perspectives

Author

Mager,Layna, Gardeen,Samantha, Carr,David R, Shahwan,Kathryn T, Mager,Layna, Gardeen,Samantha, Carr,David R, and Shahwan,Kathryn T

Abstract

Layna Mager,1,* Samantha Gardeen,2,* David R Carr,3 Kathryn T Shahwan3– 5 1College of Medicine, The Ohio State University, Columbus, OH, USA; 2Division of Dermatology, HealthPartners, Minneapolis, MN, USA; 3Department of Dermatology, The Ohio State University Medical Center, Columbus, OH, USA; 4Department of Dermatology, Altru Health System, Grand Forks, ND, USA; 5Department of Internal Medicine, University of North Dakota, Grand Forks, ND, USA*These authors contributed equally to this workCorrespondence: Kathryn T Shahwan, Email kathryn.shahwan@osumc.eduAbstract: Five percent of patients with cutaneous squamous cell carcinoma develop locally advanced or metastatic disease that is not amenable to definitive surgical or radiation therapy. Cemiplimab, an antibody against programmed death receptor-1, was approved in the United States for the treatment of locally advanced and metastatic cutaneous squamous cell carcinoma in 2018. We performed a literature review on the use of cemiplimab in cutaneous squamous cell carcinoma, with an emphasis on efficacy, safety and tolerability, patient selection, and future directions. Embase and PubMed were searched for relevant terms, and 23 peer-reviewed journal articles presenting primary data on cemiplimab treatment in 5 or more subjects with cutaneous squamous cell carcinoma were included and summarized. Objective response rates in locally advanced and metastatic disease ranged from 42.9% to 50.8% in Phase I/II clinical trials and 32– 77% (median 58%) in post-approval observational studies. Phase II trials looking at neoadjuvant use also had favorable response rates. Real-world studies demonstrated cemiplimab efficacy in periorbital tumors, tumors with large caliber perineural invasion, and tumors in solid organ transplant recipients. Cemiplimab was safe and well-tolerated in most patients. While side effects such as fatigue, diarrhea, pruritus, and rash were fairly common, only 9.8% of adverse events re

Published
2023

28. Performance of Staging Systems for Non–Head and Neck Cutaneous Squamous Cell Carcinoma.

Author

Guerra, Ricardo, Shahwan, Kathryn T., Nikahd, Melica, Hyer, Madison, and Carr, David R.

Abstract

BACKGROUND The performance of staging systems in non–head and neck cutaneous squamous cell carcinomas has not been well established. OBJECTIVE To evaluate the performance of the American Joint Committee on Cancer 8th Edition and Brigham and Women’s Hospital staging systems in non–head and neck squamous cell carcinomas. MATERIALS AND METHODS Eligible tumors were identified and staged from an existing retrospective database. Cumulative incidence function curves of any poor outcome were generated. Distinctiveness, sensitivity, specificity, positive and negative predictive value, and concordance index were calculated. RESULTS 1,042 primary tumors were included, with 38 resulting in any poor outcome and 16 in any major poor outcome. High-stage tumors represented 2.2% and 3.5% of tumors; these accounted for 10/38 of the poor outcomes (26.3%) and 8/ 16 of the major poor outcomes (50%). High-stage tumors predicted major poor outcomes with a sensitivity of 0.5 and specificity of 0.99 for the Brigham and Women’s Hospital system, and a sensitivity of 0.5 and specificity of 0.97 for the American Joint Committee on Cancer 8th edition system. The concordance index for both was 0.74. CONCLUSION Current staging systems can be used to predict poor outcomes in cutaneous squamous cell carcinomas off the head and neck. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Learning Experiences in LGBT Health During Dermatology Residency.

Author

Hyde, Jordan T., Trinidad, John C., Shahwan, Kathryn T., Cuong Nguyen, Howa Yeung, and Carr, David R.

Subjects
TRAINING of medical residents, MEDICAL students, RESIDENTS (Medicine), DERMATOLOGY, PSYCHOLOGY of students, STUDENT health services
Abstract

The article discusses role of dermatologist in lesbian, gay, bisexual, transgender (LGBT) community health concerns. It mentions LGBT education in dermatologic residency from the residents' perspective and assessed preparedness of dermatology residents to care for the community, also discusses the online surveys done on American dermatology residents through program coordinator and program director and the study shows that dermatology residents are not effectively taught LGBT health topics.

Published
2022
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43. Use of the Retroauricular Pull-Through Sandwich Flap for Repair of an Extensive Conchal Bowl Defect With Complete Cartilage Loss.

Author

Libson, Karissa, Varra, Vamsi, Shahwan, Kathryn T., and Carr, David R.

Subjects
CARTILAGE, EAR canal, MOHS surgery
Abstract

The article focuses on the reconstruction of extensive conchal bowl defects with cartilage loss, addressing challenges related to the unique shape of the concha and the need for structural support. The topics include techniques like the retroauricular pull-through sandwich flap, combining a cartilage graft and retroauricular interpolation flap, for repairing conchal bowl defects with significant cartilage loss and intact posterior auricular skin, providing aesthetic and functional outcomes.

Published
2023
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