Search

The pandemic caused significant changes and consequences in all areas of daily life. The impact of the COVID-19 virus completely changed the way of living and working, and consequently, new working conditions were imposed on it. Daily exposure to new conditions causes certain stressful situations for all, and it has aggregated mental health suffering throughout the entire world. It affects not only working employees, migrant workers, and senior citizens but also students, who can become more agitated and restless. It is becoming very common among students in this world; many of them do not realize that they are affected by stress, but it is a very serious and emerging problem about stress among students, which affects students' learning, motivation, concentration, and social interaction. The study recognizes the pervasive nature of stress among students globally, with many remaining unaware of its profound effects. Stress emerges as a substantial and escalating problem affecting students' learning, motivation, concentration, and social interactions. This research aims to know the primary stress factors confronting students during crisis situations. Data synthesis involves a simple tabulation method, offering insights into the impact of stress on social work students across key parameters such as, academic, physical, psychological, and social stress. [ABSTRACT FROM AUTHOR]

This paper focuses on hyperglycemic hyperosmolar syndrome (HHS), a unique hyperglycemic state requiring divergent diagnosis and treatment approaches from diabetic ketoacidosis (DKA) despite some shared characteristics. We introduce the mnemonic DI-FF-ER-EN-CE-S to encapsulate unique HHS management and complications. ‘DI’ emphasizes the need to delay and decrease initial insulin therapy until serum glucose decline is managed by fluid resuscitation alone. ‘FF’ stresses the importance of double fluid replacement compared to DKA due to severe dehydration and ‘ER’ electrolyte replacement due to profound losses and imbalances. ‘EN’ denotes the potential for encephalopathy and the requirement for a controlled serum osmolality reduction. ‘CE’ indicates cerebral edema, a rare complication in HHS. ‘S’ signifies systemic multiorgan failure. We categorize the associated risks into three mnemonic groups: the 3Rs (renal failure, respiratory distress, rhabdomyolysis), the 3Hs (heart failure, hypercoagulation, hyperthermia), and AP (arrhythmias, pancreatitis) to facilitate awareness and screening of HHS.

This study was designed to compare the efficiency of using conventional acupuncture (CA) and electroacupuncture (EA) in the laminitis therapy in race horses, twenty adult race horses with laminitis were randomly selected. Clinical examination was carried out and acupuncture points were determined according to the results of diagnostic palpation of acupuncture. The horses were grouped into two equal groups; the 1st group was treated daily for 6 consecutive weeks, with CA and the 2nd group with EA. evaluation of lameness was depended on the visual and objective examination using the “American Association of Equine Practitioners” (AAEP) lameness scale and confidence stride lengths criterion for forelimbs which performed by the force plate indices. The lameness level was statistically analyzed applying t-test and Wilcoxon signed-rank analysis and p-value (P

Understanding and controlling molecular transport in hydrogel materials is important for biomedical tools, including engineered tissues and drug delivery, as well as life sciences tools for single-cell analysis. Here, we scrutinize the ability of microwells—micromolded in hydrogel slabs—to compartmentalize lysate from single cells. We consider both (i) microwells that are “open” to a large fluid (i.e., liquid) reservoir and (ii) microwells that are “closed,” having been capped with either a slab of high-density polyacrylamide gel or an impermeable glass slide. We use numerical modeling to gain insight into the sensitivity of time-dependent protein concentration distributions on hydrogel partition and protein diffusion coefficients and open and closed microwell configurations. We are primarily concerned with diffusion-driven protein loss from the microwell cavity. Even for closed microwells, confocal fluorescence microscopy reports that a fluid (i.e., liquid) film forms between the hydrogel slabs (median thickness of 1.7 μm). Proteins diffuse from the microwells and into the fluid (i.e., liquid) layer, yet concentration distributions are sensitive to the lid layer partition coefficients and the protein diffusion coefficient. The application of a glass lid or a dense hydrogel retains protein in the microwell, increasing the protein solute concentration in the microwell by ∼7-fold for the first 15 s. Using triggered release of Protein G from microparticles, we validate our simulations by characterizing protein diffusion in a microwell capped with a high-density polyacrylamide gel lid (p > 0.05, Kolmogorov-Smirnov test). Here, we establish and validate a numerical model useful for understanding protein transport in and losses from a hydrogel microwell across a range of boundary conditions.

Aims This study investigated the clinical and physiological significance of the dynamic left ventricle outflow gradient observed in some patients during dobutamine stress echocardiography. Methods Three hundred and ninety-four consecutive patients completed dobutamine stress echocardiography using Doppler echocardiography to assess the presence of myocardial ischaemia and left ventricular outflow gradient. The prevalence of left ventricular outflow gradient was evaluated and correlated with echocardiographic and clinical findings. Fifteen patients with left ventricular outflow gradient during dobutamine infusion underwent exercise echocardiography for appearance of left ventricular outflow gradient. Results Sixty-nine of 394 (17·5%) patients developed a left ventricular outflow gradient of more than 36mmHg. In nine of them (13%) the anterior mitral valve leaflet had a systolic anterior motion. In 60 of the 69 patients (87%) there was a dynamic obstruction at the level of the papillary muscles. The mean intracavitary gradient was 75·4 (range 36–175)mmHg.There was no correlation between the presence or absence of a dobutamine stress echocardiography-induced left ventricle outflow gradient and chest pain or shortness of breath. In patients who developed a left ventricular outflow gradient ischaemic wall motion abnormalities occurred at a significantly lower frequency during dobutamine stress echocardiography (2·9 vs 16·4%P<0·001).None of the 15 patients who underwent exercise echo-cardiography developed significant left ventricular outflow gradient. Conclusion Left ventricular outflow gradient occurs occasionally during dobutamine stress echocardiography examination. Its presence is of no physiological or clinical significance. [ABSTRACT FROM PUBLISHER]

Broadcast is used in wireless sensor networks for operations such as software updates, network queries, and command dissemination. Applications such as battlefield control and natural resource management require not only authentication of broadcast messages, but also secrecy against eavesdroppers. In this paper we design, implement, and evaluate a novel scheme that meets the requirements of secrecy, authenticity, integrity, and freshness of broadcast messages in the context of a single-hop wireless sensor network. Our contributions are three-fold: first, we propose the use of time-varying keys (based on a key-chain) for broadcast encryption, emphasising advantages such as non-forgeability, protection against old-key compromise, and allowance for dynamic data. Second, we extend the basic key-chain mechanism to incorporate limited protection against key loss, allowing legitimate receivers to recover even if they have lost a small number of keys. Third, we prototype our scheme by incorporating it into Deluge, the network programming protocol distributed with TinyOS, and quantify its cost in terms of time, space, and power consumption on a TelosB mote platform. Our scheme represents a practical, efficient and scalable means of delivering broadcast data secretly to a large number of low-power sensor nodes.

Surgical repair of atrial septal defect in adults reduces right ventricular and right atrial diameters and volumes, and improves left ventricular filling. [ABSTRACT FROM AUTHOR]

Introduction and Importance: Solitary Fibrous Tumors are highly rare spindle cell tumors of mesenchymal origin. They comprise <2 % of all types of soft tissue tumors and are characterized by an age-adjusted annual incidence rate of 0.61 per 1 million individuals for extra-meningeal Solitary Fibrous Tumors. The disease course is mostly asymptomatic but can still present with non-specific symptoms. This results in misdiagnosis and delayed treatment. In turn, morbidity and mortality rises and it will constitute a clinical and surgical burden for the affected patients., Case Presentation: We present the case of a 67-year-old female who has a known history of controlled hypertension, who presented to our hospital complaining of non-specific pain in her right flank and lower lumbar region. Our preoperative diagnostic radiological workup demonstrated an isolated antero-sacral mass., Clinical Discussion: Comprehensive excision of the mass was laparoscopically achieved. Following the necessary analysis via histopathology and immunohistochemistry, we definitively established the diagnosis of an isolated primary benign Solitary Fibrous Tumor., Conclusion: To the best of our knowledge, no previous cases of SFTs from our country were documented. Clinical suspicion and complete surgical resection are vital determinants in treatment of such patients. Further research and documentation are warranted to set-up the necessary guidelines for preoperative assessment, intraoperative techniques, and adequate follow-up protocols to limit the ensuing morbidity and to detect any possible neoplastic recurrence., Competing Interests: Conflicts of interest Not applicable., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Bouveret Syndrome (BS) is a rare type of gallstone ileus, where a gallstone passes via a cholecystoduodenal fistula and causes gastric outlet obstruction. It comprises 0.3-0.5% of cholelithiasis complications. It primarily affects females with an average incidence age of 74 years. Gastric Neuroendocrine Tumors (G-NETs) make up merely 2% of all forms of gastric neoplasia and are known to be an extremely rare occurrence. Their annual incidence is estimated to be one to two per 1 million individuals, and they comprise 8.7% of all known neuroendocrine neoplasia of the gastrointestinal system., Case Presentation: We present the case of a 44-year-old Middle Eastern female who presented to the clinic due to multiple episodes of food containing biliary nonprojectile emesis accompanied by epigastric pain. Preoperative radiological workup revealed a Bezoar blocking the gastric outlet and a G-NET in the mucosal layer of the stomach., Clinical Discussion: Surgical intervention consisted of excising the impacted calculus to relieve the existing gastric outlet obstruction simultaneous to performing an uncut Roux-en-Y to treat the G-NET condition. The patient underwent complete recovery., Conclusion: BS is an extremely rare form of gallstone ileus and gastric outlet obstruction. Its clinical presentation is nonspecific and results in misdiagnosis. Additionally, it is rare to occur in our patient's age group. NETs are also profoundly rare forms of neoplasia. To the best of our knowledge, no previous cases of simultaneous BS and G-NET have been documented. Therefore, clinical awareness should be raised to timely implement the necessary therapeutic interventions., Competing Interests: None.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)