Search

Your search keyword '"Shah, Sanjiv"' showing total 3,534 results
Start Over Author "Shah, Sanjiv"
3,534 results on '"Shah, Sanjiv"'

1. Implementation of a Technology-Enabled Diabetes Self-Management Peer Coaching Intervention for Patients With Poorly Controlled Diabetes: Quasi-Experimental Case Study.

Author

Arévalo Avalos, Marvyn, Patel, Ashwin, Duru, Haci, Shah, Sanjiv, Rivera, Madeline, Sorrentino, Eleanor, Dy, Marika, Sarkar, Urmimala, Nguyen, Kim, Lyles, Courtney, and Aguilera, Adrian

Subjects
behavioral determinants of health, diabetes experiences, eHealth, mHealth, peer coach, peer coaching, peer support, self-management, social determinants of health, type 1 diabetes, type 2 diabetes
Abstract

BACKGROUND: Patients with diabetes experience worse health outcomes and greater health care expenditure. Improving diabetes outcomes requires involved self-management. Peer coaching programs can help patients engage in self-management while addressing individual and structural barriers. These peer coaching programs can be scaled with digital platforms to efficiently connect patients with peer supporters who can help with diabetes self-management. OBJECTIVE: This study aimed to evaluate the implementation of a technology-enabled peer coaching intervention to support diabetes self-management among patients with uncontrolled diabetes. METHODS: MetroPlusHealth, a predominant Medicaid health maintenance organization based in New York City, partnered with Pyx Health to enroll 300 Medicaid patients with uncontrolled diabetes into its 6-month peer coaching intervention. Pyx Health peer coaches conduct at least 2 evidence-based and goal-oriented coaching sessions per month with their assigned patients. These sessions are focused on addressing both behavioral and social determinants of health (SDoH) with the goal of helping patients increase their diabetes self-management literacy, implement self-management behaviors, and reduce barriers to ongoing self-care. Data analyzed in this study included patient demographic data, clinical data (patients hemoglobin A1c [HbA1c]), and program implementation data including types of behavioral determinants of health and SDoH reported by patients and types of interventions used by peer coaches. RESULTS: A total of 330 patients enrolled in the peer mentoring program and 2118 patients were considered to be on a waitlist group and used as a comparator. Patients who enrolled in the peer coaching program were older; more likely to be English speakers, female, and African American; and less likely to be White or Asian American or Pacific Islander than those in the waitlist condition, and had similar HbA1c laboratory results at baseline (intervention group 10.59 vs waitlist condition 10.62) Patients in the enrolled group had on average a -1.37 point reduction in the HbA1c score (n=70; pre: 10.99, post 9.62; P

Published
2024

2. Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes

Author

Vaduganathan, Muthiah, Filippatos, Gerasimos, Claggett, Brian L., Desai, Akshay S., Jhund, Pardeep S., Henderson, Alasdair, Brinker, Meike, Kolkhof, Peter, Schloemer, Patrick, Lay-Flurrie, James, Viswanathan, Prabhakar, Lam, Carolyn S. P., Senni, Michele, Shah, Sanjiv J., Voors, Adriaan A., Zannad, Faiez, Rossing, Peter, Ruilope, Luis M., Anker, Stefan D., Pitt, Bertram, Agarwal, Rajiv, McMurray, John J. V., and Solomon, Scott D.

Published
2024
Full Text
View/download PDF

3. Associations of Circulating Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 With Long-Term Cardiac Function.

Author

Mathew, Daniel, Peigh, Graham, Lima, Joao, Bielinski, Suzette, Larson, Nicholas, Shah, Sanjiv, Patel, Ravi, and Allison, Matthew

Subjects
atrial fibrillation, cellular adhesion molecule, heart failure, interstitial fibrosis, left atrial strain, myocardial scar, Female, Humans, Male, Atrial Fibrillation, Cicatrix, Heart Failure, Intercellular Adhesion Molecule-1, Stroke Volume, Vascular Cell Adhesion Molecule-1, Middle Aged, Aged
Abstract

BACKGROUND: Although VCAM-1 (vascular cell adhesion molecule-1) and ICAM-1 (intercellular adhesion molecule-1) have been associated with incident heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), the associations of VCAM-1 and ICAM-1 with sensitive measures of cardiac structure/function are unclear. The objective of this study is to evaluate associations between VCAM-1, ICAM-1, and measures of cardiac structure and function as potential pathways through which cellular adhesion molecules promote HFpEF and AF risk. METHODS AND RESULTS: In MESA (Multi-Ethnic Study of Atherosclerosis), we evaluated the associations of circulating VCAM-1 and ICAM-1 at examination 2 (2002-2004) with measures of cardiac structure/function on cardiac magnetic resonance imaging at examination 5 (2010-2011) after multivariable adjustment. Mediation analysis of left atrial (LA) strain on the association between VCAM-1 or ICAM-1 and AF or HFpEF was also performed. Overall, 2304 individuals (63±10 years; 47% men) with VCAM-1 or ICAM-1, cardiac magnetic resonance imaging, and covariate data were included in analysis. Higher VCAM-1 and ICAM-1 were associated with lower LA peak longitudinal strain and worse global circumferential left ventricular strain but were not associated with left ventricular myocardial scar or interstitial fibrosis. Lower LA peak longitudinal strain mediated 8% (95% CI, 2-30) of the relationship between VCAM-1 and HFpEF and 9% (95% CI, 2-21) of the relationship between VCAM-1 and AF. CONCLUSIONS: Higher VCAM-1 and ICAM-1 were associated with lower LA function and left ventricular systolic function but were not associated with myocardial scar or interstitial fibrosis. VCAM-1 and ICAM-1 may promote HFpEF and AF risk through impaired LA reservoir function.

Published
2024

4. Proceedings of the NHLBI Workshop on Artificial Intelligence in Cardiovascular Imaging: Translation to Patient Care.

Author

Dey, Damini, Arnaout, Rima, Antani, Sameer, Badano, Aldo, Jacques, Louis, Li, Huiqing, Leiner, Tim, Margerrison, Edward, Samala, Ravi, Sengupta, Partho, Shah, Sanjiv, Slomka, Piotr, Williams, Michelle, Bandettini, W, and Sachdev, Vandana

Subjects
AI algorithms, artificial intelligence, cardiovascular imaging, data science, deep learning, machine learning, United States, Humans, Artificial Intelligence, National Heart, Lung, and Blood Institute (U.S.), Predictive Value of Tests, Cardiovascular System, Patient Care
Abstract

Artificial intelligence (AI) promises to revolutionize many fields, but its clinical implementation in cardiovascular imaging is still rare despite increasing research. We sought to facilitate discussion across several fields and across the lifecycle of research, development, validation, and implementation to identify challenges and opportunities to further translation of AI in cardiovascular imaging. Furthermore, it seemed apparent that a multidisciplinary effort across institutions would be essential to overcome these challenges. This paper summarizes the proceedings of the National Heart, Lung, and Blood Institute-led workshop, creating consensus around needs and opportunities for institutions at several levels to support and advance research in this field and support future translation.

Published
2023

9. Medical Image Deidentification, Cleaning and Compression Using Pylogik

Author

Kline, Adrienne, Appadurai, Vinesh, Luo, Yuan, and Shah, Sanjiv

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Leveraging medical record information in the era of big data and machine learning comes with the caveat that data must be cleaned and de-identified. Facilitating data sharing and harmonization for multi-center collaborations are particularly difficult when protected health information (PHI) is contained or embedded in image meta-data. We propose a novel library in the Python framework, called PyLogik, to help alleviate this issue for ultrasound images, which are particularly challenging because of the frequent inclusion of PHI directly on the images. PyLogik processes the image volumes through a series of text detection/extraction, filtering, thresholding, morphological and contour comparisons. This methodology de-identifies the images, reduces file sizes, and prepares image volumes for applications in deep learning and data sharing. To evaluate its effectiveness in processing ultrasound data, a random sample of 50 cardiac ultrasounds (echocardiograms) were processed through PyLogik, and the outputs were compared with the manual segmentations by an expert user. The Dice coefficient of the two approaches achieved an average value of 0.976. Next, an investigation was conducted to ascertain the degree of information compression achieved using the algorithm. Resultant data was found to be on average ~72% smaller after processing by PyLogik. Our results suggest that PyLogik is a viable methodology for data cleaning and de-identification, determining ROI, and file compression which will facilitate efficient storage, use, and dissemination of ultrasound data. Variants of the pipeline have also been created for use with other medical imaging data types., Comment: updates needed to manuscript

Published
2023

10. Author Correction: Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes

Author

Vaduganathan, Muthiah, Filippatos, Gerasimos, Claggett, Brian L., Desai, Akshay S., Jhund, Pardeep S., Henderson, Alasdair, Brinker, Meike, Kolkhof, Peter, Schloemer, Patrick, Lay-Flurrie, James, Viswanathan, Prabhakar, Lam, Carolyn S. P., Senni, Michele, Shah, Sanjiv J., Voors, Adriaan A., Zannad, Faiez, Rossing, Peter, Ruilope, Luis M., Anker, Stefan D., Pitt, Bertram, Agarwal, Rajiv, McMurray, John J. V., and Solomon, Scott D.

Published
2024
Full Text
View/download PDF

11. Interatrial Shunt Devices

Author

Safder, Taimur, Shah, Sanjiv, Narang, Akhil, Kelsey, Anita M., editor, Vemulapalli, Sreek, editor, and Sadeghpour, Anita, editor

Published
2024
Full Text
View/download PDF

13. Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Trainor, Patrick J, Brambatti, Michela, Carlisle, Samantha M, Mullick, Adam E, Shah, Sanjiv J, Kahlon, Tanvir, Mostacero, Diana Otero, Mousavi, Hossein, Morgan, Erin S, Tami, Yvonne, Michos, Erin D, Ouyang, Pamela, Tsimikas, Sotirios, and DeFilippis, Andrew P

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Disparities, Clinical Research, Minority Health, Women's Health, Cardiovascular, Atherosclerosis, Hypertension, Aging, 2.1 Biological and endogenous factors, Male, Adult, Female, Humans, Angiotensinogen, Aldosterone, Renin-Angiotensin System, Blood Pressure, angiotensinogen, blood pressure, hypertensions, renin-angiotensin-aldosterone system, sex difference, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundAngiotensinogen is the proximal precursor of the angiotensin peptide hormones of the renin-angiotensin-aldosterone system (RAAS). Clinical trials are ongoing targeting angiotensinogen for the treatment of hypertension and heart failure. The epidemiology of angiotensinogen is not well defined, particularly its relationship to ethnicity, sex, and blood pressure (BP)/hypertension.ObjectivesThe authors sought to determine the relationship of circulating angiotensinogen levels to ethnicity, sex, BP, incident hypertension, and prevalent hypertension in a modern sex-balanced ethnically diverse cohort.MethodsPlasma angiotensinogen levels were measured in 5,786 participants from the MESA (Multi-Ethnic Study of Atherosclerosis). Linear, logistic, and Cox proportional hazards models were utilized to examine the associations of angiotensinogen with BP, prevalent hypertension, and incident hypertension, respectively.ResultsAngiotensinogen levels were significantly higher in females than males and differed across self-reported ethnicities with the ordering (from highest to lowest): White, Black, Hispanic, and Chinese adults. Higher levels were associated with higher BP and odds of prevalent hypertension, after adjusting for other risk factors. Equivalent relative differences in angiotensinogen were associated with greater differences in BP in males vs females. In males not taking RAAS-blocking medications, a standard deviation increment in log-angiotensinogen was associated with 2.61 mm Hg higher systolic BP (95% CI: 1.49-3.80), while in females the same increment in angiotensinogen was associated with 0.97 mm Hg higher systolic BP (95% CI: 0.30-1.65).ConclusionsSignificant differences in angiotensinogen levels are present between sexes and ethnicities. A positive association is present between levels and prevalent hypertension and BP, which differs between sexes.

Published
2023

15. Mitochondria regulate proliferation in adult cardiac myocytes

Author

Waypa, Gregory B., Smith, Kimberly A., Mungai, Paul T., Dudley, Vincent J., Helmin, Kathryn A., Singer, Benjamin D., Peek, Clara Bien, Bass, Joseph, Nelson, Lauren, Shah, Sanjiv J., Ofman, Gaston, Wasserstrom, J. Andrew, Muller, William A., Misharin, Alexander V., Budinger, G.R. Scott, Abdala-Valencia, Hiam, Chandel, Navdeep S., Dokic, Danijela, Bartom, Elizabeth, Zhang, Shuang, Tatekoshi, Yuki, Mahmoodzadeh, Amir, Ardehali, Hossein, Thorp, Edward B., and Schumacker, Paul T.

Subjects
Oxidative phosphorylation -- Health aspects, RNA sequencing -- Analysis, Ischemia -- Complications and side effects -- Care and treatment, Epigenetic inheritance -- Analysis, Mitochondrial DNA -- Analysis, Health care industry, Care and treatment, Analysis, Complications and side effects, Health aspects
Abstract

Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype that utilizes mitochondrial oxidative phosphorylation but loses mitotic capacity. We tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. We deleted Uqcrfsl (mitochondrial Rieske iron- sulfur protein, RISP) in hearts of adult mice. As RISP protein decreased, heart mitochondrial function declined, and glucose utilization increased. Simultaneously, the hearts underwent hyperplastic remodeling during which cardiomyocyte number doubled without cellular hypertrophy. Cellular energy supply was preserved, AMPK activation was absent, and mTOR activation was evident. In ischemic hearts with RISP deletion, new cardiomyocytes migrated into the infarcted region, suggesting the potential for therapeutic cardiac regeneration. RNA sequencing revealed upregulation of genes associated with cardiac development and proliferation. Metabolomic analysis revealed a decrease in a-ketoglutarate (required for TET-mediated demethylation) and an increase in 5-adenosylmethionine (required for methyltransferase activity). Analysis revealed an increase in methylated CpGs near gene transcriptional start sites. Genes that were both differentially expressed and differentially methylated were linked to upregulated cardiac developmental pathways. We conclude that decreased mitochondrial function and increased glucose utilization can restore mitotic capacity in adult cardiomyocytes, resulting in the generation of new heart cells, potentially through the modification of substrates that regulate epigenetic modification of genes required for proliferation., Introduction Mitochondria generate ATP through oxidative phosphorylation (OXPHOS), but they also participate in diverse biological functions that include redox signaling (1), metabolite signaling (2), calcium signaling (3), and the generation [...]

Published
2024
Full Text
View/download PDF

16. Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program

Author

Verma, Subodh, Petrie, Mark C., Borlaug, Barry A., Butler, Javed, Davies, Melanie J., Kitzman, Dalane W., Shah, Sanjiv J., Rönnbäck, Cecilia, Abildstrøm, Steen Z., Liisberg, Karoline, Wolf, Dennis, von Lewinski, Dirk, Lelonek, Malgorzata, Melenovsky, Vojtech, Senni, Michele, and Kosiborod, Mikhail N.

Published
2024
Full Text
View/download PDF

18. Effect of Semaglutide on Cardiac Structure and Function in Patients With Obesity-Related Heart Failure

Author

Solomon, Scott D., Ostrominski, John W., Wang, Xiaowen, Shah, Sanjiv J., Borlaug, Barry A., Butler, Javed, Davies, Melanie J., Kitzman, Dalane W., Verma, Subodh, Abildstrøm, Steen Z., Nygaard Einfeldt, Mette, Rasmussen, Søren, Abhayaratna, Walter P., Ahmed, Fozia Z., Ben-Gal, Tuvia, Chopra, Vijay, Ito, Hiroshi, Merkely, Bela, Núñez, Julio, Senni, Michele, van der Meer, Peter, Wolf, Dennis, Petrie, Mark C., and Kosiborod, Mikhail N.

Published
2024
Full Text
View/download PDF

20. Clinical-transcriptional prioritization of the circulating proteome in human heart failure

Author

Perry, Andrew S., Amancherla, Kaushik, Huang, Xiaoning, Lance, Michelle L., Farber-Eger, Eric, Gajjar, Priya, Amrute, Junedh, Stolze, Lindsey, Zhao, Shilin, Sheng, Quanhu, Joynes, Cassandra M., Peng, Zhongsheng, Tanaka, Toshiko, Drakos, Stavros G., Lavine, Kory J., Selzman, Craig, Visker, Joseph R., Shankar, Thirupura S., Ferrucci, Luigi, Das, Saumya, Wilcox, Jane, Patel, Ravi B., Kalhan, Ravi, Shah, Sanjiv J., Walker, Keenan A., Wells, Quinn, Tucker, Nathan, Nayor, Matthew, Shah, Ravi V., and Khan, Sadiya S.

Published
2024
Full Text
View/download PDF

21. Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials

Author

Kosiborod, Mikhail N, Deanfield, John, Pratley, Richard, Borlaug, Barry A, Butler, Javed, Davies, Melanie J, Emerson, Scott S, Kahn, Steven E, Kitzman, Dalane W, Lingvay, Ildiko, Mahaffey, Kenneth W, Petrie, Mark C, Plutzky, Jorge, Rasmussen, Søren, Rönnbäck, Cecilia, Shah, Sanjiv J, Verma, Subodh, Weeke, Peter E, and Lincoff, A Michael

Published
2024
Full Text
View/download PDF

22. Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant

Author

Giro, Pedro, Filipp, Mallory, Zhang, Michael J., Moser, Ethan D., Thorp, Edward B., Dalal, Prarthana J., Shah, Ravi V., Ellinor, Patrick T., Cunningham, Jonathan W., Jurgens, Sean J., Sinha, Arjun, Rasmussen-Torvik, Laura, Kizer, Jorge, Taylor, Kent D., Greenland, Philip, Psaty, Bruce M., Tracy, Russell P., Chen, Lin Yee, Shah, Amil M., Yu, Bing, Shah, Sanjiv J., and Patel, Ravi B.

Published
2024
Full Text
View/download PDF

25. Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial

Author

Borlaug, Barry A., Kitzman, Dalane W., Davies, Melanie J., Rasmussen, Søren, Barros, Eric, Butler, Javed, Einfeldt, Mette Nygaard, Hovingh, G. Kees, Møller, Daniél Vega, Petrie, Mark C., Shah, Sanjiv J., Verma, Subodh, Abhayaratna, Walter, Ahmed, Fozia Z., Chopra, Vijay, Ezekowitz, Justin, Fu, Michael, Ito, Hiroshi, Lelonek, Małgorzata, Melenovsky, Vojtech, Núñez, Julio, Perna, Eduardo, Schou, Morten, Senni, Michele, van der Meer, Peter, Von Lewinski, Dirk, Wolf, Dennis, and Kosiborod, Mikhail N.

Published
2023
Full Text
View/download PDF

28. Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials

Author

Litwin, Sheldon E., Komtebedde, Jan, Borlaug, Barry A., Kaye, David M., Hasenfuβ, Gerd, Kawash, Rami, Hoendermis, Elke, Hummel, Scott L., Cikes, Maja, Gustafsson, Finn, Chung, Eugene S., Mohan, Rajeev C., Sverdlov, Aaron L., Swarup, Vijendra, Winkler, Sebastian, Hayward, Christopher S., Bergmann, Martin W., Bugger, Heiko, McKenzie, Scott, Nair, Ajith, Rieth, Andreas, Burkhoff, Daniel, Cutlip, Donald E., Solomon, Scott D., van Veldhuisen, Dirk J., Leon, Martin B., and Shah, Sanjiv J.

Published
2024
Full Text
View/download PDF

29. Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE‐HF trial roll‐in cohort

Author

Fudim, Marat, Fail, Peter S, Litwin, Sheldon E, Shaburishvili, Tamaz, Goyal, Parag, Hummel, Scott L, Borlaug, Barry A, Mohan, Rajeev C, Patel, Ravi B, Mitter, Sumeet S, Klein, Liviu, Rocha‐Singh, Krishna, Patel, Manesh R, Reddy, Vivek Y, Burkhoff, Daniel, and Shah, Sanjiv J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Patient Safety, Prevention, Heart Disease, Cardiovascular, Aged, Female, Heart Failure, Humans, Male, Pulmonary Wedge Pressure, Splanchnic Nerves, Stroke Volume, Ventricular Function, Left, Heart failure with preserved ejection fraction, Splanchnic nerve ablation, Therapeutics, Clinical trial, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsIn heart failure (HF) with preserved ejection fraction (HFpEF), excessive redistribution of blood volume into the central circulation leads to elevations of intracardiac pressures with exercise limitations. Splanchnic ablation for volume management (SAVM) has been proposed as a therapeutic intervention. Here we present preliminary safety and efficacy data from the initial roll-in cohort of the REBALANCE-HF trial.Methods and resultsThe open-label (roll-in) arm of REBALANCE-HF will enrol up to 30 patients, followed by the randomized, sham-controlled portion of the trial (up to 80 additional patients). Patients with HF, left ventricular ejection fraction (LVEF) ≥50%, and invasive peak exercise pulmonary capillary wedge pressure (PCWP) ≥25 mmHg underwent SAVM. Baseline and follow-up assessments included resting and exercise PCWP, New York Heart Association (NYHA) class, Kansas City Cardiomyopathy Questionnaire (KCCQ), 6-min walk test, and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Efficacy and safety were assessed at 1 and 3 months. Here we report on the first 18 patients with HFpEF that have been enrolled into the roll-in, open-label arm of the study across nine centres; 14 (78%) female; 16 (89%) in NYHA class III; and median (interquartile range) age 75.2 (68.4-81) years, LVEF 61.0 (56.0-63.2)%, and average (standard deviation) 20 W exercise PCWP 36.4 (±8.6) mmHg. All 18 patients were successfully treated. Three non-serious moderate device/procedure-related adverse events were reported. At 1-month, the mean PCWP at 20 W exercise decreased from 36.4 (±8.6) to 28.9 (±7.8) mmHg (p

Published
2022

30. Association of Pericardial Fat with Cardiac Structure, Function, and Mechanics: The Multi-Ethnic Study of Atherosclerosis

Author

Min, Jeff, Putt, Mary E, Yang, Wei, Bertoni, Alain G, Ding, Jingzhong, Lima, Joao AC, Allison, Matthew A, Barr, R Graham, Al-Naamani, Nadine, Patel, Ravi B, Beussink-Nelson, Lauren, Kawut, Steven M, Shah, Sanjiv J, and Freed, Benjamin H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Atherosclerosis, Clinical Research, Heart Disease, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Adipose Tissue, Adiposity, Adult, Cardiomyopathies, Humans, Pericardium, Pericardial fat, Echocardiography, Myocardial strain analysis, Early heart failure, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundPericardial fat has been associated with adverse cardiovascular outcomes through adiposity-associated inflammation and insulin resistance, which in turn are linked to cardiac dysfunction. We sought to evaluate the association between pericardial fat volume and cardiac structure and function in adults without baseline cardiovascular disease.MethodsWe analyzed data from the Multi-Ethnic Study of Atherosclerosis. Linear regression was used to examine the association between pericardial fat volume (by cardiac computed tomography during exam 1, 2000-2002) and cardiac function by echocardiography, six-minute walk distance (6MWD), and symptom severity as assessed using the Kansas City Cardiomyopathy Questionnaire-12 (exam 6, 2016-18).ResultsAmong 3,032 participants, each 1 SD (39.3 cm3) increase in pericardial fat volume was associated with lower (worse) absolute left atrial reservoir strain (β = -0.98%; 95% CI, -1.29, -0.68; P

Published
2022

33. SNPs Filtered by Allele Frequency Improve the Prediction of Hypertension Subtypes

Author

Li, Yiming, Shah, Sanjiv J., Arnett, Donna, Irvin, Ryan, and Luo, Yuan

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning, Quantitative Biology - Populations and Evolution, Statistics - Applications
Abstract

Hypertension is the leading global cause of cardiovascular disease and premature death. Distinct hypertension subtypes may vary in their prognoses and require different treatments. An individual's risk for hypertension is determined by genetic and environmental factors as well as their interactions. In this work, we studied 911 African Americans and 1,171 European Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) cohort. We built hypertension subtype classification models using both environmental variables and sets of genetic features selected based on different criteria. The fitted prediction models provided insights into the genetic landscape of hypertension subtypes, which may aid personalized diagnosis and treatment of hypertension in the future., Comment: Submitted to the 12th International Workshop on Biomedical and Health Informatics (BHI 2021)

Published
2021

35. Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis: Insights From THAOS

Author

Emdin, Michele, Hanna, Mazen, Azevedo, Olga, Lino Cirami, Calogero, Gonzalez Costello, Jose, Slosky, David, Moelgaard, Henning, Nativi Nicolau, Jose, Hummel, Scott, Jeon, Eun-Seok, Fine, Nowell, Murali, Srinivas, Miller, Edward, Shah, Sanjiv, Witteles, Ronald, Waddington-Cruz, Marcia, Lenihan, Daniel, Sekijima, Yoshiki, Van Cleemput, Johan, Correia, Edileide de Barros, Cariou, Eve, Quan, Dianna, Freimer, Miriam, Steidley, David, Hüsing-Kabar, Anna, Plante-Bordeneuve, Violaine, Nienhuis, Hans, Wixner, Jonas, Ralph, Jeffrey, Ventura, Hector, Zivkovic, Sasa, Delgado, Diego, Fernandéz Torrón, Roberto, Gottlieb, Stephen, Cotts, William, Tallaj, Jose, Brunkhorst, Robert, Polydefkis, Michael, Mueller, Christopher, Tschoepe, Carsten, Gonzalez Moreno, Juan, Sarswat, Nitasha, Luo, Jin, Tauras, James, Warner, Alberta, Mora-Ayestaran, Nerea, Dispenzieri, Angela, Kristen, Arnt V., Maurer, Mathew S., Diemberger, Igor, Drachman, Brian M., Grogan, Martha, Gupta, Pritam, Glass, Oliver, Amass, Leslie, and Garcia-Pavia, Pablo

Published
2024
Full Text
View/download PDF

37. 2-Year Outcomes of an Atrial Shunt Device in HFpEF/HFmrEF: Results From REDUCE LAP-HF II

Author

Gustafsson, Finn, Petrie, Mark C., Komtebedde, Jan, Swarup, Vijendra, Winkler, Sebastian, Hasenfuß, Gerd, Borlaug, Barry A., Mohan, Rajeev C., Flaherty, James D., Sverdlov, Aaron L., Fail, Peter S., Chung, Eugene S., Lurz, Philipp, Lilly, Scott, Kaye, David M., Cleland, John G.F., Cikes, Maja, Leon, Martin B., Cutlip, Donald E., van Veldhuisen, Dirk J., Solomon, Scott D., and Shah, Sanjiv J.

Published
2024
Full Text
View/download PDF

43. Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: Rationale, Design and Lead-in Phase Results of the REBALANCE-HF Trial

Author

Fudim, Marat, Litwin, Sheldon E., Borlaug, Barry A., Mohan, Rajeev C., Price, Matthew J., Fail, Peter, Zirakashvili, Teona, Shaburishvili, Tamaz, Goyal, Parag, Hummel, Scott L., Patel, Ravi B., Reddy, Vivek Y., Burkhoff, Daniel, Patel, Manesh R., Somo, Sami I., and Shah, Sanjiv J.

Published
2024
Full Text
View/download PDF

48. Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure.

Author

Sinha, Arjun, Bavishi, Avni, Hibler, Elizabeth A, Yang, Eric H, Parashar, Susmita, Okwuosa, Tochukwu, DeCara, Jeanne M, Brown, Sherry-Ann, Guha, Avirup, Sadler, Diego, Khan, Sadiya S, Shah, Sanjiv J, Yancy, Clyde W, and Akhter, Nausheen

Abstract

Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.

Published
2022

49. Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus—results from the randomized, double-blind, placebo-controlled EmDia trial

Author

Prochaska, Jürgen H., Jünger, Claus, Schulz, Andreas, Arnold, Natalie, Müller, Felix, Heidorn, Marc William, Baumkötter, Rieke, Zahn, Daniela, Koeck, Thomas, Tröbs, Sven-Oliver, Lackner, Karl J., Daiber, Andreas, Binder, Harald, Shah, Sanjiv J., Gori, Tommaso, Münzel, Thomas, and Wild, Philipp S.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results