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5. Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies

Author

Shah, Ashu, Chaudhary, Sanjib, Lakshmanan, Imayavaramban, Aithal, Abhijit, Kisling, Sophia G., Sorrell, Claire, Marimuthu, Saravanakumar, Gautam, Shailendra K., Rauth, Sanchita, Kshirsagar, Prakash, Cox, Jesse L., Natarajan, Gopalakrishnan, Bhatia, Rakesh, Mallya, Kavita, Rachagani, Satyanarayana, Nasser, Mohd Wasim, Ganti, Apar Kishor, Salgia, Ravi, Kumar, Sushil, Jain, Maneesh, Ponnusamy, Moorthy P., and Batra, Surinder K.

Published
2023
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7. Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma

Author

Lakshmanan, Imayavaramban, Marimuthu, Saravanakumar, Chaudhary, Sanjib, Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Muniyan, Sakthivel, Chirravuri-Venkata, Ramakanth, Atri, Pranita, Rauth, Sanchita, Nimmakayala, Rama Krishna, Siddiqui, Jawed Akhtar, Gautam, Shailendra K., Shah, Ashu, Natarajan, Gopalakrishnan, Parte, Seema, Bhyravbhatla, Namita, Mallya, Kavita, Haridas, Dhanya, Talmon, Geoffrey A., Smith, Lynette M., Kumar, Sushil, Ganti, Apar Kishor, Jain, Maneesh, Ponnusamy, Moorthy P., and Batra, Surinder K.

Published
2022
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18. Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

Author

Marimuthu, Saravanakumar, primary, Lakshmanan, Imayavaramban, primary, Muniyan, Sakthivel, primary, Gautam, Shailendra K., primary, Nimmakayala, Rama Krishna, primary, Rauth, Sanchita, primary, Atri, Pranita, primary, Shah, Ashu, primary, Bhyravbhatla, Namita, primary, Mallya, Kavita, primary, Grandgenett, Paul M., primary, Hollingsworth, Michael A., primary, Datta, Kaustubh, primary, Jain, Maneesh, primary, Ponnusamy, Moorthy P., primary, and Batra, Surinder K., primary

Published
2023
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19. Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

Author

Marimuthu, Saravanakumar, primary, Lakshmanan, Imayavaramban, primary, Muniyan, Sakthivel, primary, Gautam, Shailendra K., primary, Nimmakayala, Rama Krishna, primary, Rauth, Sanchita, primary, Atri, Pranita, primary, Shah, Ashu, primary, Bhyravbhatla, Namita, primary, Mallya, Kavita, primary, Grandgenett, Paul M., primary, Hollingsworth, Michael A., primary, Datta, Kaustubh, primary, Jain, Maneesh, primary, Ponnusamy, Moorthy P., primary, and Batra, Surinder K., primary

Published
2023
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20. Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

Author

Marimuthu, Saravanakumar, primary, Lakshmanan, Imayavaramban, primary, Muniyan, Sakthivel, primary, Gautam, Shailendra K., primary, Nimmakayala, Rama Krishna, primary, Rauth, Sanchita, primary, Atri, Pranita, primary, Shah, Ashu, primary, Bhyravbhatla, Namita, primary, Mallya, Kavita, primary, Grandgenett, Paul M., primary, Hollingsworth, Michael A., primary, Datta, Kaustubh, primary, Jain, Maneesh, primary, Ponnusamy, Moorthy P., primary, and Batra, Surinder K., primary

Published
2023
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21. Small molecule inhibitor against onco-mucins disrupts Src/FosL1 axis to enhance gemcitabine efficacy in pancreatic ductal adenocarcinoma

Author

Zhang, Chunmeng, primary, Atri, Pranita, additional, Nallasamy, Palanisamy, additional, Parte, Seema, additional, Rauth, Sanchita, additional, Nimmakayala, Rama Krishna, additional, Marimuthu, Saravanakumar, additional, Chirravuri-Venkata, Ramakanth, additional, Bhatia, Rakesh, additional, Halder, Sushanta, additional, Shah, Ashu, additional, Cox, Jesse L., additional, Smith, Lynette, additional, Kumar, Sushil, additional, Foster, Jason M., additional, Kukreja, Rakesh C., additional, Seshacharyulu, Parthasarathy, additional, Ponnusamy, Moorthy P., additional, and Batra, Surinder K., additional

Published
2022
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23. MUC16 promotes Triple-Negative Breast Cancer Lung Metastasis by Modulating RNA- Binding Protein ELAVL1/HUR

Author

Chaudhary, Sanjib, primary, Maurya, Shailendra Kumar, additional, Nallasamy, Palanisamy, additional, Saravanakumar, Marimuthu, additional, Shah, Ashu, additional, Atri, Pranita, additional, Ramakanth, Chirravuri Venkata, additional, Lele, Subodh M., additional, Seshacharyulu, Parthasarathy, additional, Ponnusamy, Moorthy P., additional, Nasser, Mohd W., additional, Batra, Surinder K., additional, and Lakshmanan, Imayavaramban, additional

Published
2022
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24. MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

Author

Marimuthu, Saravanakumar, primary, Lakshmanan, Imayavaramban, additional, Muniyan, Sakthivel, additional, Gautam, Shailendra K., additional, Nimmakayala, Rama Krishna, additional, Rauth, Sanchita, additional, Atri, Pranita, additional, Shah, Ashu, additional, Bhyravbhatla, Namita, additional, Mallya, Kavita, additional, Grandgenett, Paul M., additional, Hollingsworth, Michael A., additional, Datta, Kaustubh, additional, Jain, Maneesh, additional, Ponnusamy, Moorthy P., additional, and Batra, Surinder K., additional

Published
2022
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25. SUMO Modification of PAF1/PD2 Enables PML Interaction and Promotes Radiation Resistance in Pancreatic Ductal Adenocarcinoma

Author

Rauth, Sanchita, primary, Karmakar, Saswati, additional, Shah, Ashu, additional, Seshacharyulu, Parthasarathy, additional, Nimmakayala, Rama Krishna, additional, Ganguly, Koelina, additional, Bhatia, Rakesh, additional, Muniyan, Sakthivel, additional, Kumar, Sushil, additional, Dutta, Samikshan, additional, Lin, Chi, additional, Datta, Kaustubh, additional, Batra, Surinder K., additional, and Ponnusamy, Moorthy P., additional

Published
2021
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27. Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

Author

Ganguly, Koelina, primary, Krishn, Shiv Ram, additional, Rachagani, Satyanarayana, additional, Jahan, Rahat, additional, Shah, Ashu, additional, Nallasamy, Palanisamy, additional, Rauth, Sanchita, additional, Atri, Pranita, additional, Cox, Jesse L., additional, Pothuraju, Ramesh, additional, Smith, Lynette M., additional, Ayala, Sudhua, additional, Evans, Christopher, additional, Ponnusamy, Moorthy P., additional, Kumar, Sushil, additional, Kaur, Sukhwinder, additional, and Batra, Surinder K., additional

Published
2021
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29. Abstract 4438: Role of post translational modification of PAF1/PD2 in gemcitabine resistance of pancreatic cancer

Author

Rauth, Sanchita, primary, Karmakar, Saswati, additional, Shah, Ashu, additional, Nimmakayala, Rama Krishna, additional, Bhatia, Rakesh, additional, Muniyan, Sakthivel, additional, Kumar, Sushil, additional, Dutta, Samikshan, additional, Datta, Kaustubh, additional, Batra, Surinder K., additional, and Ponnusamy, Moorthy Palanimuthu, additional

Published
2019
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30. MUC16 as a novel target for cancer therapy

Author

Aithal, Abhijit, primary, Rauth, Sanchita, additional, Kshirsagar, Prakash, additional, Shah, Ashu, additional, Lakshmanan, Imayavaramban, additional, Junker, Wade M., additional, Jain, Maneesh, additional, Ponnusamy, Moorthy P., additional, and Batra, Surinder K., additional

Published
2018
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32. Effect of Organic Solvents on the Molten Globule State of Procerain: -Sheet to -Helix Switchover in Presence of Trifluoroethanol

Author

Dubey, Vikash, Shah, Ashu, Jagannadham, Medicherla, and Kayastha, Arvind

Abstract

The effect of methanol and trifluoroethanol (TFE) on the structure and folding of molten globule state of procerain, a cysteine protease from Calotropis procera, was studied by circular dichroism spectroscopy. The magnitude of ellipticity at 215 nm, as a measure of -sheet content, is dependent on the concentration of the TFE. Interestingly, a switch over from the -sheet structure of the molten globule state to -helix was observed at 60 TFE and the ellipticity at 222 nm increased as a function of TFE concentration beyond this critical TFE concentration. Temperature induced unfolding of the molten globule state of procerain in 10 methanol showed stabilization of -rich domain with concomitant destabilization of -rich domain. Using higher concentration of methanol (20-40 ) had no stabilizing effect on the -rich domain however, the -rich domain was destabilized, indicating that the stability of the domains were not interdependent and that a low concentration of methanol induced stabilization in -rich domain.

Published
2006

33. Effect of organic solvents on the molten globule state of procerain: beta-sheet to alpha-helix switchover in presence of trifluoroethanol.

Author

Dubey VK, Shah A, Jagannadham MV, and Kayastha AM

Subjects
Calotropis, Circular Dichroism, Hot Temperature, Protein Denaturation drug effects, Protein Structure, Secondary drug effects, Thermodynamics, Trifluoroethanol pharmacology, Cysteine Endopeptidases chemistry, Solvents chemistry, Trifluoroethanol chemistry
Abstract

The effect of methanol and trifluoroethanol (TFE) on the structure and folding of molten globule state of procerain, a cysteine protease from Calotropis procera, was studied by circular dichroism spectroscopy. The magnitude of ellipticity at 215 nm, as a measure of beta-sheet content, is dependent on the concentration of the TFE. Interestingly, a switch over from the beta-sheet structure of the molten globule state to alpha-helix was observed at 60% TFE and the ellipticity at 222 nm increased as a function of TFE concentration beyond this critical TFE concentration. Temperature induced unfolding of the molten globule state of procerain in 10% methanol showed stabilization of alpha-rich domain with concomitant destabilization of beta-rich domain. Using higher concentration of methanol (20-40 %) had no stabilizing effect on the alpha-rich domain however, the beta-rich domain was destabilized, indicating that the stability of the domains were not interdependent and that a low concentration of methanol induced stabilization in alpha-rich domain.

Published
2006
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