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7. Neonatal Outcomes among Fetuses with an Abdominal Circumference <3rd %ile and Estimated Fetal Weight 3rd to 9th %ile Compared to Fetuses with an EFW <3rd %ile.

Author

Horgan, Rebecca, Nehme, Lea, Jensen, Hannah J., Shah, Anika P., Saal, Ryan, Onishi, Kazuma, Kawakita, Tetsuya, Martins, Juliana G., and Abuhamad, Alfred

Subjects
ABDOMEN, ACADEMIC medical centers, PATIENTS, SMALL for gestational age, BODY weight, FETAL growth retardation, NEONATAL intensive care units, HOSPITAL admission & discharge, PREGNANCY outcomes, FETAL ultrasonic imaging, RETROSPECTIVE studies, TERTIARY care, NEONATAL intensive care, PERINATAL death, INFANT death, DESCRIPTIVE statistics, LONGITUDINAL method, NEONATAL necrotizing enterocolitis, ODDS ratio, GESTATIONAL age, ARTIFICIAL respiration, SEIZURES (Medicine), FETAL development, COMPARATIVE studies, RESPIRATORY distress syndrome, CONFIDENCE intervals, NEONATAL sepsis, RETROLENTAL fibroplasia, CEREBRAL hemorrhage
Abstract

Objective Fetal growth restriction (FGR) is defined as an estimated fetal weight (EFW) or abdominal circumference (AC) <10th percentile (%ile) for gestational age (GA). An EFW <3rd %ile for GA is considered severe FGR (sFGR). It remains unknown if fetuses with isolated AC <3rd %ile should be considered sFGR. Our primary objective was to assess composite neonatal outcomes in fetuses with an AC <3 rd %ile and overall EFW 3rd to 9th %ile compared with those with an EFW <3rd %ile. Study Design This retrospective cohort study was undertaken at a tertiary academic center from January 2016 to December 2021. Inclusion criteria were singleton fetuses with an EFW <3rd %ile (Group 1) or AC <3rd %ile with EFW 3rd to 9th %ile (Group 2) at 28 weeks' gestation or greater. Exclusion criteria were multiple gestations, presence of a major fetal anomaly, resolution of FGR, genetic syndrome, or infection. Composite neonatal outcome was defined by any of the following: neonatal intensive care unit admission >48 hours, necrotizing enterocolitis, sepsis, respiratory distress syndrome, mechanical ventilation, retinopathy of prematurity, seizures, intraventricular hemorrhage, stillbirth, or death before discharge. Small for gestational age (SGA) was defined as birth weight <10th %ile for GA. Results A total of 743 patients fulfilled our study criteria, with 489 in Group 1 and 254 in Group 2. The composite neonatal outcome occurred in 281 (57.5%) neonates in Group 1 and 53 (20.9%) in Group 2 (p < 0.01). The rates of SGA at birth were 94.9 and 75.6% for Group 1 and Group 2, respectively (OR 5.99, 95% confidence interval 3.65–9.82). Conclusion Although AC <3rd %ile with EFW 3rd to 9th %ile is associated with a lower frequency of SGA and neonatal morbidity than EFW <3 %ile, fetuses with AC <3 %ile still exhibited moderate rates of these adverse perinatal outcomes. Consideration should be given to inclusion of an AC <3rd %ile with EFW 3rd to 9th %ile as a criterion for sFGR. However, prospective studies comparing delivery at 37 versus 38 to 39 weeks' gestation are needed to ensure improved outcomes before widespread adaptation in clinical practice. Key Points The composite neonatal outcome occurred in 57.5% of fetuses with an overall EFW <3rd %ile and 20.9% of fetuses with an AC <3rd %ile but EFW 3rd to 9th %ile. Both groups demonstrated a high positive predictive value for SGA birth weight. Consideration should be given to inclusion of an AC <3rd %ile as a criterion for sFGR. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response

Author

Gurbel, Paul A., primary, Bliden, Kevin P., additional, Kundan, Parshotam, additional, Kraft, Danielle, additional, Parekh, Rueshil, additional, Singh, Sahib, additional, Babu, Aravind D., additional, Shah, Anika P., additional, Chaudhary, Rahul, additional, and Tantry, Udaya S., additional

Published
2023
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12. CRISPR Screens in Colon Cancer

Author

Shah, Anika and Cooper, Garrett

Abstract

CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats – Cas9) is an innovative technology that enables researchers to interrogate the function of genes through precise editing of genes. Researchers have recently utilized this technology to assess the function of all genes in a system using CRISPR-Cas9 screens. These screens are powerful techniques that enable the unbiased interrogation of gene function in various model systems and organisms. These pooled screens employ a predefined set of genetic perturbations called sgRNAs, which are introduced into a pool of cells. This pool of cells, each with its own genetic perturbation, is then grown in competition with each other. After a period of competition, the effects of each perturbation are assessed through the sequencebased counting of each specific mutation, or sgRNA. CRISPR-Cas9 screens have revealed numerous molecular pathways that may confer resistance or sensitivity to various biological challenges. This review will describe how these techniques have advanced our understanding of colon cancer and demonstrate how these screens can be modeled and optimized in silico using computational simulation tools. It will further describe how these screens have been applied to living organisms and provide insight into how these may advance our understanding of various biological mechanisms and organ functions.

Published
2023
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15. MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis

Author

Del Rosario, Othello, primary, Suresh, Karthik, additional, Kallem, Medha, additional, Singh, Gayatri, additional, Shah, Anika, additional, Zheng, Linda, additional, Yun, Xin, additional, Philip, Nicolas M., additional, Putcha, Nirupama, additional, McClure, Marni B., additional, Jiang, Haiyang, additional, D’Alessio, Franco, additional, Srivastava, Meera, additional, Bera, Alakesh, additional, Shimoda, Larissa A., additional, Merchant, Michael, additional, Rane, Madhavi J., additional, Machamer, Carolyn E., additional, Mock, Jason, additional, Hagan, Robert, additional, Koch, Abigail L., additional, Punjabi, Naresh M., additional, Kolb, Todd M., additional, and Damarla, Mahendra, additional

Published
2023
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16. Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer

Author

Suresh, Karthik, primary, Del Rosario, Othello, additional, Kallem, Medha, additional, Singh, Gayatri, additional, Shah, Anika, additional, Zheng, Linda, additional, Yun, Xin, additional, Philip, Nicolas M., additional, Putcha, Nirupama, additional, McClure, Marni B., additional, Jiang, Haiyang, additional, D’Alessio, Franco, additional, Srivastava, Meera, additional, Bera, Alakesh, additional, Shimoda, Larissa A., additional, Merchant, Michael, additional, Rane, Madhavi J., additional, Machamer, Carolyn E., additional, Mock, Jason, additional, Hagan, Robert, additional, Koch, Abigail L., additional, Punjabi, Naresh M., additional, Kolb, Todd M., additional, and Damarla, Mahendra, additional

Published
2023
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19. Complement-Binding Donor-Specific Anti-HLA Antibodies: Biomarker for Immunologic Risk Stratification in Pediatric Kidney Transplantation Recipients

Author

Sigurjonsdottir, Vaka K., primary, Purington, Natasha, additional, Chaudhuri, Abanti, additional, Zhang, Bing M., additional, Fernandez-Vina, Marcelo, additional, Palsson, Runolfur, additional, Kambham, Neeraja, additional, Charu, Vivek, additional, Piburn, Kim, additional, Maestretti, Lynn, additional, Shah, Anika, additional, Gallo, Amy, additional, Concepcion, Waldo, additional, and Grimm, Paul C., additional

Published
2022
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21. MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

Author

Del Rosario, Othello, primary, Suresh, Karthik, additional, Kallem, Medha, additional, Singh, Gayatri, additional, Shah, Anika, additional, Xin, Yun, additional, Philip, Nicolas, additional, D'Alessio, Franco, additional, Srivastava, Meera, additional, Bera, Alakesh, additional, Shimoda, Larissa, additional, Merchant, Michael, additional, Rane, Madhavi, additional, Machamer, Carolyn, additional, Mock, Jason, additional, Hagan, Robert, additional, Kolb, Todd, additional, and Damarla, Mahendra, additional

Published
2021
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24. Should abdominal circumference

Author

Horgan, Rebecca, Nehme, Lea, Jensen, Hannah J., Shah, Anika P., Saal, Ryan C., Onishi, Kazuma, Kawakita, Tetsuya, Martins, Juliana Gevaerd, and Abuhamad, Alfred

Published
2023
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25. CMC extends test-optional policy to fall 2022 application cycle

Author

Shah, Anika KimmeRicha

Subjects
News, opinion and commentary, Sports and fitness, Claremont McKenna College
Abstract

Byline: Anika KimmeRicha Shah Claremont McKenna College will not require students to submit ACT or SAT scores until fall 2022. (Chris Nardi Çó The Student Life) Claremont McKenna College announced [...]

Published
2021

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