Background: Laparotomy incision closure can be done using different suture materials and techniques. These factors affect the incidence of post operative wound complications such as wound dehiscence, surgical site infection, stitch granuloma, incisional hernia. Material & Methods: Study included 50 patients who underwent laparotomy from January 2019 to October 2019. Equal number of cases(25 each) were studied for closure with two suture materials; Polyglactin and Polypropylene. The patients were followed-up at 1 week, 2 weeks, 1 month and then 3 months after surgery. Result: The incidence of wound infection was higher in Polyglactin (12%) compared to Polypropylene (8%) whereas incidence of stitch granuloma is 3 (12%) in Polypropylene as compared to 1(4%) in Polyglactin group. Wound dehiscence incidence was more in polyglactin (12%) as compared to polypropylene (4%) group. None of patients developed incisional hernia upto 3 months of follow up visits. Conclusion: Suture materials like polypropylene, polyglactin, PDS, nylon can be used for laparotomy incision closure. Use of absorbable suture material is more related to development of post operative surgical site infection, wound dehiscence, incisional hernia whereas stitch granuloma is more related to use of non-absorbable suture material. Overall, polypropylene has higher merits over polyglactin for laparotomy mass closure in present study. [ABSTRACT FROM AUTHOR]