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33. The interactive effect of vitamin D3 supplementation and vitamin D receptor polymorphisms on weight and body composition in overweight women with hypovitaminosis D: a randomized, double-blind, placebo-controlled clinical trial

Author

Ebrahimof, Samira, Angoorani, Pooneh, Shab-Bidar, Sakineh, Abedidni, Somayeh, Jahangir, Farzaneh, and Hedayati, Mehdi

Subjects
Obesity -- Risk factors -- Diet therapy, Dietary supplements -- Health aspects -- Physiological aspects -- Usage, Genetic polymorphisms -- Physiological aspects, Vitamin D3 -- Health aspects -- Physiological aspects -- Usage, Vitamin D deficiency -- Complications and side effects, Biological sciences
Abstract

Different responses to vitamin D supplementation may be due to genes involved in vitamin D metabolism, including the vitamin D receptor (VDR) gene. The present study aimed to determine the interactive effect of vitamin D supplementation and VDR polymorphisms, including FokI (rs2228570) and BsmI (1544410) on weight and body composition in overweight women with hypovitaminosis D. This study comprised two phases: a double-blind, randomized and a before-after clinical trial. In the first phase, 50 healthy overweight women aged 20-45 years with hypovitaminosis D were randomly categorized into intervention and control groups and were given 50 000 IU/w vitamin D3 or placebo for 12 weeks. In the second phase, 75 women received 50 000 IU/w of vitamin D3 for 12 weeks. All variables were measured at baseline and after 12 weeks. Circulating 25(OH)D was measured using an ELISA kit. Anthropometric indices were calculated according to standard protocol (WHO-TRH-854). Body composition was determined using the body impedance analysis method. The VDR polymorphisms were detected using the PCR sequence. Supplementation resulted in a significant increase in the level of 25(OH)D in the intervention group but did not affect the anthropometric profile of the subjects. When considering FokI genotypes, carriers of the FF genotype had higher fat mass reduction than carriers of Ff + ff genotypes. Key words: vitamin D3 supplementation, VDR polymorphism, overweight, hypovitaminosis, body composition Les reactions differentielles a la supplementation en vitamine D pourraient etre le fait de genes jouant un role dans la biotransformation de la vitamine D, y compris le gene du recepteur de la vitamine D (VDR). La presente etude visait a etablir l'effet de l'interaction entre la supplementation en vitamine D et les polymorphismes de VDR, y compris FokI (rs2228570) et BsmI (1544410), sur le poids et la composition corporelle chez des femmes en surpoids presentant une hypovitaminose D. Cette etude comprenait deux phases : un essai clinique a double insu avec repartition aleatoire et un autre de type avant/apres. Au cours de la premiere phase, nous avons reparti aleatoirement 50 femmes en surpoids, mais en bonne sante, agees de 20 a 45 ans et presentant une hypovitaminose D dans des groupes intervention et temoin auxquelles nous avons administre pendant 12 semaines de la vitamine D3 a 50 000 UI/semaine ou un placebo. Au cours de la seconde phase, nous avons administre de la vitamine D3 a 50 000 UI/semaine a 75 femmes pendant 12 semaines. Nous avons mesure toutes les variables au debut de l'etude et apres 12 semaines. Nous avons mesure la 25(OH)D en circulation a l'aide d'un kit ELISA. Nous avons calcule les donnees anthropometriques selon un protocole standard (WHO-TRH-854). Nous avons etabli la composition corporelle a l'aide de la methode d'analyse d'impedance corporelle. Nous avons decele les polymorphismes de VDR a l'aide de la technique de PCR et analyse sequentielle. La supplementation a entraine une augmentation marquee des taux de 25(OH)D dans le groupe intervention, mais sans modification du profil anthropometrique des sujets. Quant aux genotypes de FokI, les porteuses du genotype FF presentaient un abaissement de la masse adipeuse plus importante que les porteuses des genotypes Ff et ff. Mots-cles : supplementation en vitamine D3, polymorphisme de VDR, surpoids, hypovitaminose, composition corporelle, Introduction Vitamin D deficiency due to insufficient sun exposure and inadequate intake or absorption of vitamin D has become a significant health problem. One billion people have hypovitaminosis D deficiency [...]

Published
2022
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