205 results on '"Sha, Shi"'
Search Results
2. Coherent signal localization with multiple arrays: a successive perspective.
- Author
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Haowei Zeng, Sha Shi, Heng Yue, and Jianfeng Li
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- 2023
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3. A novel application of probabilistic teleportation: p-Rabin qubit-oblivious transfer
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MeiLing, Zhang, Jin, Li, YuanHua, Liu, sha, Shi, Dong, Zheng, QingJi, Zheng, and Min, Nie
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Quantum Physics - Abstract
All existing quantum oblivious transfer protocols are to realize the oblivious transfer of bit or bit-string. In this paper, p-Rabin quantum oblivious transfer of a qubit (abbr. p-Rabin qubit-OT) is achieved by using a probabilistic teleportation (abbr. PT) protocol. Here, this is the first time that the concept of qubit-OT is presented. As the PT protocol is able to transfer an (un)known pure state with a certain probability, this feature makes the PT protocol well fit for Rabin OT. Furthermore, the PT protocol can be used for OT of a bit by encoding classical bit with two pre-agreed orthogonal states. Finally, security analysis shows that the PT protocol can be against participants attacks, and what's more, the discussion of relationship with no-go theorem demonstrates that the PT protocol is able to evade the no-go theorem., Comment: 11 pages
- Published
- 2018
4. Comment on Quantum teleportation and information splitting via four-qubit cluster state and a Bell state
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Meiling, Zhang, Sha, Shi, Yuanhua, Liu, Qingji, Zheng, and Yunjiang, Wang
- Subjects
Quantum Physics - Abstract
We study the quantum controlled and probabilistic teleportation protocol via a four-cluster state (Front. Phys. (2017) 12: 120306). The protocol cannot achieve the goal that if the teleportation fails, it can be repeated without copies of the teleported state. And the reason is that all the information of the teleported state shifts to the receiver's particle after Bell measurement and the information cannot shift back to the sender without other entangled states. To realize the claimed goal, a new quantum controlled and probabilistic teleportation protocol using the same four-cluster state is presented. Because no information of the teleported stated is lost during the whole teleportation process, the teleportation process can be repeated until the teleportation success., Comment: 7 pages, 3 figures
- Published
- 2018
5. Physiological and transcriptome analyses reveal the response of Ammopiptanthus mongolicus to extreme seasonal temperatures in a cold plateau desert ecosystem
- Author
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Zimeng Yang, Yiying Liu, Hang Han, Xinyu Zhao, Siyu Chen, Guofang Li, Sha Shi, and Jinchao Feng
- Subjects
Medicine ,Science - Abstract
Abstract Ammopiptanthus mongolicus is the only evergreen broad-leaved shrub present in arid areas of Northwest China and plays an important role in maintaining the stability of the local desert ecosystem. It can survive under extreme temperatures (e.g., extreme low temperature: − 24.8 °C and extreme high temperature: 37.7 °C). To understand the gene expression-physiological regulation network of A. mongolicus in extreme temperature environments, we monitored the changes in gene expression and photosynthetic traits of the leaves. The results showed that at low temperatures, the net photosynthetic rates (A), Fv'/Fm' and electron transport rate (ETR) decreased, the Fv/Fm ratio was only 0.32, and the proportion of nonregulatory heat dissipation Y(NO) increased. Based on a KEGG analysis of the differentially expressed genes, 15 significantly enriched KEGG pathways were identified, which were mainly related to circadian rhythm, photosynthesis, lipid metabolism, carbohydrate metabolism, plant hormones and other life activities. At high temperatures, the A value increased, and the proportion of regulatory energy dissipation Y(NPQ) increased. The KEGG analysis identified 24 significantly enriched KEGG pathways, which are mainly related to circadian rhythm, carbon sequestration of photosynthesis, carotenoid biosynthesis, secondary metabolites, cofactors and vitamin metabolism. In general, at the expense of photosynthesis, A. mongolicus can ensure the survival of leaves by increasing Y(NO) levels, regulating the circadian rhythm, increasing the synthesis of unsaturated fatty acids and changing the role of plant hormones. Under high-temperature stress, a high photosynthetic capacity was maintained by adjusting the stomatal conductance (gsw), increasing Y(NPQ), consuming excess light energy, continuously assembling and maintaining PSII, and changing the production of antioxidants.
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- 2022
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6. A Preprocessing Manifold Learning Strategy Based on t-Distributed Stochastic Neighbor Embedding
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Sha Shi, Yefei Xu, Xiaoyang Xu, Xiaofan Mo, and Jun Ding
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manifold learning ,t-SNE ,dimensionality reducing ,k-nearest neighbor ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
In machine learning and data analysis, dimensionality reduction and high-dimensional data visualization can be accomplished by manifold learning using a t-Distributed Stochastic Neighbor Embedding (t-SNE) algorithm. We significantly improve this manifold learning scheme by introducing a preprocessing strategy for the t-SNE algorithm. In our preprocessing, we exploit Laplacian eigenmaps to reduce the high-dimensional data first, which can aggregate each data cluster and reduce the Kullback–Leibler divergence (KLD) remarkably. Moreover, the k-nearest-neighbor (KNN) algorithm is also involved in our preprocessing to enhance the visualization performance and reduce the computation and space complexity. We compare the performance of our strategy with that of the standard t-SNE on the MNIST dataset. The experiment results show that our strategy exhibits a stronger ability to separate different clusters as well as keep data of the same kind much closer to each other. Moreover, the KLD can be reduced by about 30% at the cost of increasing the complexity in terms of runtime by only 1–2%.
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- 2023
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7. Etiological and epidemiological features of acute respiratory infections in China
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Zhong-Jie Li, Hai-Yang Zhang, Li-Li Ren, Qing-Bin Lu, Xiang Ren, Cui-Hong Zhang, Yi-Fei Wang, Sheng-Hong Lin, Xiao-Ai Zhang, Jun Li, Shi-Wen Zhao, Zhi-Gang Yi, Xiao Chen, Zuo-Sen Yang, Lei Meng, Xin-Hua Wang, Ying-Le Liu, Xin Wang, Ai-Li Cui, Sheng-Jie Lai, Tao Jiang, Yang Yuan, Lu-Sha Shi, Meng-Yang Liu, Yu-Liang Zhu, An-Ran Zhang, Zhi-Jie Zhang, Yang Yang, Michael P. Ward, Lu-Zhao Feng, Huai-Qi Jing, Liu-Yu Huang, Wen-Bo Xu, Yu Chen, Jian-Guo Wu, Zheng-Hong Yuan, Meng-Feng Li, Yu Wang, Li-Ping Wang, Li-Qun Fang, Wei Liu, Simon I. Hay, George F. Gao, Wei-Zhong Yang, and The Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team
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Science - Abstract
China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.
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- 2021
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8. Numerical Investigation of the Stress on a Cylinder Exerted by a Stratified Current Flowing on Uneven Ground
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Yin Wang, Ming Xu, Lingling Wang, Sha Shi, Chenhui Zhang, Xiaobin Wu, Hua Wang, Xiahui Xiong, and Chunling Wang
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internal wave ,terrain ,force on the cylinder ,flow field ,numerical simulation ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
In this study, a three-dimensional internal wave (IW)—cylinder—terrain coupled numerical model is established. Based on the large-eddy simulation (LES) method, the IW mechanical characteristics of the cylinder and the flow field evolution around the cylinder over different types of terrains are explored. The similarities and differences in the mechanical characteristics of the cylinders in the environments with and without terrains are compared. The research results show that, when the IWs propagate over terrain, the waveform structures are prone to continuous changes. The intense reverse alternating flow of the upper and the lower water, bounded by the pycnocline, results in huge IWs forces differences between the case without terrains and the cases with terrains. In the case without terrains, the maximum horizontal resultant force on the cylinder is positive, while the resultant forces are negative in the cases with terrain. Compared with the case without terrain, the shallow-water effect caused by the combined action of the terrain and the IWs enhances the flow field strength, making the lower parts of the cylinder suffer larger horizontal forces in the opposite direction to the IW direction. Moreover, the additional vortices produced by the interaction between the IWs and the terrain causes a more complex flow field around the cylinder and the greater forces on the cylinder.
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- 2023
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9. A Rate Scalable Construction of Non-Homogeneous Quantum LDPC Codes of CSS Type Based on Balanced Incomplete Block Design.
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Yun-Jiang Wang, Zhuo-Yan Xiao, Xing-Yu Xiong, Junzhi Yan, Chao Wang, and Sha Shi
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- 2021
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10. Etiological, epidemiological, and clinical features of acute diarrhea in China
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Li-Ping Wang, Shi-Xia Zhou, Xin Wang, Qing-Bin Lu, Lu-Sha Shi, Xiang Ren, Hai-Yang Zhang, Yi-Fei Wang, Sheng-Hong Lin, Cui-Hong Zhang, Meng-Jie Geng, Xiao-Ai Zhang, Jun Li, Shi-Wen Zhao, Zhi-Gang Yi, Xiao Chen, Zuo-Sen Yang, Lei Meng, Xin-Hua Wang, Ying-Le Liu, Ai-Li Cui, Sheng-Jie Lai, Meng-Yang Liu, Yu-Liang Zhu, Wen-Bo Xu, Yu Chen, Jian-Guo Wu, Zheng-Hong Yuan, Meng-Feng Li, Liu-Yu Huang, Zhong-Jie Li, Wei Liu, Li-Qun Fang, Huai-Qi Jing, Simon I. Hay, George F. Gao, Wei-Zhong Yang, and The Chinese Centers for Disease Control and Prevention (CDC) Etiology of Diarrhea Surveillance Study Team
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Science - Abstract
Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.
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- 2021
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11. Extended sparse array exploiting fourth-order cumulant for DOA estimation of non-Gaussian signals: Increased DOF perspective.
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Sha Shi, Heng Yue, Liancheng Zhao, and Qiang Zhao
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- 2023
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12. Highly Secure Privacy-Preserving Outsourced k-Means Clustering under Multiple Keys in Cloud Computing.
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Ying Zou 0008, Zhen Zhao 0005, Sha Shi, Lei Wang 0031, Yunfeng Peng, Yuan Ping, and Baocang Wang
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- 2020
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13. Improved Cloud-Assisted Privacy-Preserving Profile-Matching Scheme in Mobile Social Networks.
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Ying Zou 0008, Yanting Chai, Sha Shi, Lei Wang 0031, Yunfeng Peng, Yuan Ping, and Baocang Wang
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- 2020
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14. Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study
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Li-Ping Wang, Yang Yuan, Ying-Le Liu, Qing-Bin Lu, Lu-Sha Shi, Xiang Ren, Shi-Xia Zhou, Hai-Yang Zhang, Xiao-Ai Zhang, Xin Wang, Yi-Fei Wang, Sheng-Hong Lin, Cui-Hong Zhang, Meng-Jie Geng, Jun Li, Shi-Wen Zhao, Zhi-Gang Yi, Xiao Chen, Zuo-Sen Yang, Lei Meng, Xin-Hua Wang, Ai-Li Cui, Sheng-Jie Lai, Meng-Yang Liu, Yu-Liang Zhu, Wen-Bo Xu, Yu Chen, Zheng-Hong Yuan, Meng-Feng Li, Liu-Yu Huang, Huai-Qi Jing, Zhong-Jie Li, Wei Liu, Li-Qun Fang, Jian-Guo Wu, Simon I. Hay, Wei-Zhong Yang, and George F. Gao
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meningitis ,encephalitis ,sentinel surveillance ,etiology ,China ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China. Methods: Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods. Findings: Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children
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- 2022
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15. Experimental Study on Measurement of Drag Coefficient of Sandy Soil Nonlinear Vadose
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Yu-ping Xu, Jing-yuan Liu, Xiu-wei Chai, and Sha-sha Shi
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The seepage characteristics of sand affect its strength, mechanical deformation characteristics, and find safety and stability. The drag coefficient is a dimensionless physical quantity expressing the interaction between fluid and particles, it is also an important parameter that characterizes the permeability of granular soils. Through the seepage test of standard sand with single particle sizes and different grades, analyze the seepage laws of standard sand with different particle sizes in the Darcy and non-Darcy seepage. The relationship between parameters a and b in the seepage equation and porosity (n), average particle size (d50), nonuniformity coefficient (CU), and curvature coefficient (CC), and their influence degree were studied. An empirical formula for determining the permeability coefficient of standard sand is established. By adding a correction factor and verifying its rationality, the empirical formula of standard sand permeability parameters is finally obtained.
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- 2022
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16. DOA Estimation for Non-Gaussian Signals: Three-Level Nested Array and a Successive SS-MUSIC Algorithm
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Sha Shi, Haowei Zeng, Heng Yue, Changbo Ye, and Jianfeng Li
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Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Cellular telephone services industry. Wireless telephone industry ,HE9713-9715 - Abstract
Direction of arrival (DOA) estimation for non-Gaussian signals using three-level nested array (THL-NA) is investigated in this paper. Motivation from larger consecutive degree of freedom (DOF) and array aperture, the THL-NA is proposed, which can take full advantages of the consecutive coarrays of TL-NA and has the closed-form expression of DOF. Specifically, firstly, the array aperture is expanded by the second order sum coarray (2-SC) of the proposed array, secondly, the nested relationship between subarrays is employed to obtain the difference coarray of 2-SC (2-DCSC), finally, a consecutive virtual array with large array aperture is obtained. Besides, a successive SS-MUSIC algorithm is proposed, which employs the spatial smoothing estimating signal parameter via rotational invariance techniques (SS-ESPRIT) algorithm and partial spectrum searching multiple signal classification (PSS-MUSIC) to obtain initial estimations and fine estimations, respectively, resulting in a better balance between computational complexity and estimation accuracy.
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- 2022
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17. Thermal-constrained energy efficient real-time scheduling on multi-core platforms
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Sha, Shi, Wen, Wujie, Chaparro-Baquero, Gustavo A., and Quan, Gang
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- 2019
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18. Fingerprint Recognition Strategies Based on a Fuzzy Commitment for Cloud-Assisted IoT: A Minutiae-Based Sector Coding Approach.
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Sha Shi, Jia Cui, Xin-Li Zhang, Yang Liu, Jing-Liang Gao, and Yun-Jiang Wang
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- 2019
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19. On the parity-check matrix of generalized concatenated code.
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Sha Shi, Yang Liu, Junzhi Yan, Jingliang Gao, and Yun-Jiang Wang
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- 2020
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20. Oxidative Stress Marker Aberrations in Multiple Sclerosis: A Meta-Analysis Study
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Shu-Yao Zhang, Lue-Ning Gui, Yi-Ying Liu, Sha Shi, and Yong Cheng
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oxidative stress ,multiple sclerosis ,peripheral blood ,cerebrospinal fluid ,meta-analysis ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Oxidative stress has been suggested to play a key role in multiple sclerosis (MS), but clinical data on oxidative stress markers in MS patients were inconsistent. This study sought to quantitatively summarize the data of oxidative stress markers in the blood and cerebrospinal fluid (CSF) of patients with MS in the literature. We conducted a systematic search of PubMed and Web of Science and included studies if they provided data on the concentrations of oxidative stress markers in the peripheral blood and CSF of MS patients and healthy control (HC) subjects. The systematic search resulted in the inclusion of 31 studies with 2,001 MS patients and 2,212 HC subjects for meta-analysis. Random-effects meta-analysis demonstrated that patients with MS had significantly increased concentrations of blood oxidative stress markers compared with HC subjects for malondialdehyde (MDA; Hedges' g, 2.252; 95% CI, 1.080 to 3.424; p < 0.001) and lipid hydroperoxide by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH; Hedges' g, 0.383; 95% CI, 0.065 to 0.702; p = 0.018). In contrast, concentrations of albumin (Hedges' g, −1.036; CI, −1.679 to −0.394; p = 0.002) were significantly decreased in MS patients when compared with those in HC subjects. However, the other analyzed blood oxidative stress markers did not show significant differences between cases and controls. Furthermore, this meta-analysis showed significant association between CSF MDA and MS (Hedges' g, 3.275; 95% CI, 0.859 to 5.691; p = 0.008). Taken together, our results revealed increased blood and CSF MDA and decreased blood albumin levels in patients with MS, strengthening the clinical evidence of increased oxidative stress in MS.
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- 2020
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21. Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer
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Xing Xin, Ti Wen, Li-Bao Gong, Ming-Ming Deng, Ke-Zuo Hou, Lu Xu, Sha Shi, Xiu-Juan Qu, Yun-Peng Liu, Xiao-Fang Che, and Yue-E Teng
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FEN1 ,ROS ,arsenic trioxide ,GSH ,Nrf2 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, which is very difficult to treat and commonly develops resistance to chemotherapy. The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. Our data showed that ATO could increase the expression of FEN1, and the knockdown of FEN1 could significantly enhance the sensitivity of TNBC cells to ATO both in vitro and in vivo. Further mechanism studies revealed that silencing FEN1 in combination with low doses of ATO might increase intracellular ROS and reduce glutathione (GSH) levels, by reducing the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2); elevating ROS leaded to apoptosis and p38 and JNK pathway activating. In conclusion, our study suggested the combination of FEN1 knockdown and ATO could induce TNBC cell death by promoting ROS production. FEN1 knockdown can effectively decrease the application concentrations of ATO, thus providing a possibility for the treatment of TNBC with ATO.
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- 2020
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22. C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells
- Author
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Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu, and Yuee Teng
- Subjects
Breast cancer ,Tamoxifen ,Resistance ,HER2 ,C-Cbl ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resistance is not well understood. Here we examined whether ER-c-Src-HER2 complex formation is involved in tamoxifen resistance. Methods MTT and colony formation assays were used to measure cell viability and proliferation. Western blot was used to detect protein expression and protein complex formations were detected by immunoprecipitation and immunofluorescence. SiRNA was used to examine the function of HER2 in of BT474 cells. An in vivo xenograft animal model was established to examine the role of c-Cbl in tumor growth. Results MTT and colony formation assay showed that BT474 cells are resistant to tamoxifen and T47D cells are sensitive to tamoxifen. Immunoprecipitation experiments revealed ER-c-Src-HER2 complex formation in BT474 cells but not in T47D cells. However, ER-c-Src-HER2 complex formation was detected after overexpressing HER2 in T47D cells and these cells were more resistant to tamoxifen. HER2 knockdown by siRNA in BT474 cells reduced ER-c-Src-HER2 complex formation and reversed tamoxifen resistance. ER-c-Src-HER2 complex formation was also disrupted and tamoxifen resistance was reversed in BT474 cells by the c-Src inhibitor PP2 and HER2 antibody trastuzumab. Nystatin, a lipid raft inhibitor, reduced ER-c-Src-HER2 complex formation and partially reversed tamoxifen resistance. ER-c-Src-HER2 complex formation was disrupted by overexpression of c-Cbl but not by the c-Cbl ubiquitin ligase mutant. In addition, c-Cbl could reverse tamoxifen resistance in BT474 cells, but the ubiquitin ligase mutant had no effect. The effect of c-Cbl was validated in BT474 tumor-bearing nude mice in vivo. Immunofluorescence also revealed ER-c-Src-HER2 complex formation was reduced in tumor tissues of nude mice with c-Cbl overexpression. Conclusions Our results suggested that c-Cbl can reverse tamoxifen resistance in HER2-overexpressing breast cancer cells by inhibiting the formation of the ER-c-Src-HER2 complex.
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- 2018
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23. Enhanced Successive Cancellation List Decoding of Polar Codes.
- Author
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Sha Shi, Bing Han 0007, Jing-Liang Gao, and Yun-Jiang Wang
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- 2017
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24. Discussion of 'Some Insights on Flow over Sharp-Crested Weirs Using Computational Fluid Dynamics: Implications for Enhanced Flow Measurement'
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Li Yao, Sha Shi, Hao Chen, and Arniza Fitri
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Agricultural and Biological Sciences (miscellaneous) ,Water Science and Technology ,Civil and Structural Engineering - Published
- 2023
25. Peripheral Blood and Cerebrospinal Fluid Cytokine Levels in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis
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Ting Sun, Xi Chen, Sha Shi, Qingshan Liu, and Yong Cheng
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inflammation ,cytokine ,Guillain Barré Syndrome ,peripheral blood ,cerebrospinal fluid ,meta-analysis ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Guillain Barré Syndrome (GBS) is an autoimmune disorder caused by the immune-mediated damage of the peripheral nervous system. Increasing evidence suggests that inflammatory cytokines are important mediators for the onset and progression of GBS. A number of clinical studies have demonstrated elevated levels of T helper-1 (Th1-), Th2-, and Th17-related cytokines in patients with GBS; however, the results were inconsistent across studies.Methods: We performed a systematic review and a meta-analysis of studies comparing the levels of inflammatory cytokines in the cerebrospinal fluid and peripheral blood between patients with GBS and healthy individuals, using Comprehensive Meta-Analysis Version 2 software. A database search identified 30 studies comprising 1,302 patients with GBS and 1,073 healthy controls.Results: The random-effects meta-analysis demonstrated that peripheral blood tumor necrosis factor-α (Hedges g, 1.544; 95% confidence interval (CI), 0.923–2.165; p < 0.001), interleukin-1β (IL-1β; Hedges g, 0.678; 95% CI, 0.183–1.172; p = 0.007), IL-6 (Hedges g, 0.630; 95% CI, 0.100–1.160; p = 0.02), IL-4 (Hedges g, 0.822; 95% CI, 0.220–1.423; p = 0.007), IL-17 (Hedges g, 1.452; 95% CI, 0.331–2.573; p = 0.011), interferon-γ (Hedges g, 1.104; 95% CI, 0.490–1.719; p < 0.001), and C-reactive protein (Hedges g, 0.909; 95% CI, 0.453–1.365; p < 0.001) levels were significantly increased in patients with GBS when compared with healthy controls. Contrastingly, the blood IL-10 and transforming growth factor-β levels were not significantly associated with GBS. Furthermore, the meta-analysis found that cerebrospinal fluid IL-17 levels were significantly associated with GBS (Hedges g, 1.882; 95% CI, 0.104–3.661; p = 0.038).Conclusion: Altogether, our results clarified the circulating inflammatory cytokine profile in patients with GBS, and revealed that Th1-, Th2-, and Th17-related cytokines were highly elevated in the GBS patients, suggesting the potential use of these cytokines as biomarkers for GBS.
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- 2019
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26. Key Blasting Parameters for Deep-Hole Excavation in an Underground Tunnel of Phosphorite Mine
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Xiu-wei Chai, Sha-sha Shi, Yao-feng Yan, Jian-guo Li, and Long Zhang
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Ever increasing mine production capacity and mechanized operations enable advanced drilling equipment to be widely adopted in underground mines. In order to achieve satisfactory blasting performance in tunnel advance, there is a critical need to optimize the blasting technique to match the large deep-hole drilling capability. In this study, through theoretical analysis of tunnel blasting, the layout of cutting holes was found to be the key factor controlling the blasting performance. The deep-hole cutting effect was first investigated by analyzing the influence of the free surface of a hollow hole using the fluid-structure interaction modeling method in ANSYS/LS-DYNA. Then the rock dynamic evolution processes of blasting using a double-cavity grooving and a four-cavity grooving were compared and analyzed towards an understanding of the influence of the spacing and layout of cutting holes on the blasting performance. The comparison results show that four empty hole cut layouts yield larger effective free surface than that of the two empty hole cut layouts. This is because larger compensation space for breaking of rock and expansion of gas is more conducive to improving the energy utilization rate of explosives and thus improving the blasting performance and the footage of cyclic blasting. The results indicated that the blasting performance can be improved by reserving reasonable compensation space in the grooving area.
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- 2019
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27. Thermal Aware System-Wide Reliability Optimization for Automotive Distributed Computing Applications
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Bankar, Ajinkya S., primary, Sha, Shi, additional, Bhimani, Janki, additional, Chaturvedi, Vivek, additional, and Quan, Gang, additional
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- 2022
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28. Spread of Staphylococcus aureus between medical staff and high-frequency contact surfaces in a large metropolitan hospital
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Li-sha Shi, Chun-juan Xu, Hong-bing Jia, Wei Chen, Xiao-feng Zhou, and Xiu-hua Li
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Pathogenic bacteria ,Hand contamination ,Medical staff ,Nosocomial infection ,Cross-contamination ,Nursing ,RT1-120 - Abstract
Objective: To examine whether bacteria are transferred between the hands of medical staff and high-frequency contact surfaces within and between departments of a major metropolitan hospital, and to further analyze the patterns of cross-transmission. Methods: Microbiological samples were collected from the hands of 112 hospital employees as well as from 120 high-frequency contact surfaces in four hospital departments. Samples were collected on agar plates, analyzed for the presence of Staphylococcus aureus or methicillin-resistant S. aureus (MRSA) by standard microbiology testing, and partially genotyped using pulsed-field gel electrophoresis. Results: Genetically identical MRSA was identified on the surface of an electrocardiography device in the medical intensive care unit and on the same type of device in the neurosurgical unit. Genetically similar S. aureus was identified on an infusion pump in the medical intensive care unit and on the hands of several doctors in a different department who regularly use that pump. Genetically identical S. aureus was also identified on bedside rail restraint in the medical intensive care unit and on the hands of the nurse in the neurosurgical unit. Finally, genetically similar MRSA was identified both on the surface of an electrocardiography device and on the suction apparatus in the medical intensive care unit. Conclusion: Cross-contamination of S. aureus or MRSA on medical workers' hands and contact surfaces was demonstrated within and between departments of a large metropolitan hospital. Improvements are needed in medical staff hygiene habits and in the cleaning of high-frequency contact surfaces to help prevent and control nosocomial infections.
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- 2015
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29. Sesquiterpenoids from Artemisia vestita and Their Antifeedant and Antifungal Activities
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Ying-Hui Ding, Hui-Ting Wang, Sha Shi, Yao Meng, Jin-Chao Feng, and Hai-Bo Wu
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artemisia vestita ,sesquiterpenoids ,absolute configuration ,antifeedant ,antifungal ,Organic chemistry ,QD241-441 - Abstract
Four new sesquiterpenoids, named artemivestinolide D−G (1−4) and three known sesquiterpenoids (5−7), were isolated from Artemisia vestita. The structures of these new compounds were determined based on extensive spectroscopic data analyses. Furthermore, the electronic circular dichroism data determined the absolute configurations of the new compounds. The antifeedant and antifungal activities of the isolates were evaluated against third-instar larvae of Plutella xylostella and three plant pathogenic fungi. Compounds 1−7 showed moderate antifeedant activities and compounds 1−4 and 6−7 exhibited antifungal activities.
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- 2019
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30. Research on Mobile Electronically Published Materials Protection.
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Sha Shi, Qiaoyan Wen, and Mingzhu Li
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- 2011
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31. Distributed Steganography.
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Xin Liao, Qiao-Yan Wen, and Sha Shi
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- 2011
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32. Study on the Technology of the Secure Computation in the Different Adversarial Models
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Zhang, Xiaolan, Sun, Hongxiang, Wen, Qiaoyan, Sha, Shi, Kacprzyk, Janusz, editor, Jin, David, editor, and Lin, Sally, editor
- Published
- 2011
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33. Bioinformatic Analysis Revealing Independent Predictors of Poor Prognosis and Immunologic/Metastatic Behaviors in Squamous Cell Lung Cancer
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Jinshan Yan, Fangjian Na, Xinyao Li, Sha Shi, Xin Li, Junli Hao, Ying Wu, Xiaoyu Gang, and Mingfang Zhao
- Abstract
Background Squamous cell carcinoma of the lung (LUSC) is a malignant tumor with a high mortality rate and few treatment options. Methods This study explored novel biomarkers and the related mechanisms in LUSC development via integrated bioinformatics analysis based on multiple databases. TCGA-LUSC, GSE30219, and GSE37745 datasets were selected, and univariate Cox analysis was applied to each. The candidate prognostic genes were those survival hazardous genes that overlapped in the three datasets and were further applied in Kaplan-Meier log-rank test. Receiver-operating characteristics (ROC) curves were made to compare the candidate prognostic genes’ predictive accuracy and traditional clinicopathological parameters (CPPs). Moreover, fast preranked gene set enrichment analysis, single-sample gene set enrichment analysis, gene set variation analysis, and correlation analysis was sequentially performed to explore the candidate prognostic genes’ potential functions. Results Based on the data for stage I–III LUSC, aldehyde dehydrogenase 7 family member A1 (ALDH7A1), progestogen-associated endometrial protein (PAEP), and vav guanine nucleotide exchange factor 2 (VAV2) were identified as prognostic candidate biomarkers that could improve the accuracy of traditional CPPs for predicting overall survival (OS). Moreover, ALDH7A1, PAEP, and VAV2 were, respectively, correlated with the immune microenvironment and epithelial–mesenchymal transition (EMT), but not with tumor mutation burden, microsatellite instability, or CPPs. The EMT biomarker vimentin (but not E-cadherin) was consistent with ALDH7A1, PAEP, and VAV2. Conclusion This study elucidated the prognostic roles and potential functions of ALDH7A1, PAEP, and VAV2 in LUSC.
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- 2022
34. A Rate Scalable Construction of Non-Homogeneous Quantum LDPC Codes of CSS Type Based on Balanced Incomplete Block Design
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Xiao Zhuoyan, Chao Wang, Xiong Xingyu, Sha Shi, Yun-Jiang Wang, and Jun-Zhi Yan
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Discrete mathematics ,020206 networking & telecommunications ,Cascading Style Sheets ,02 engineering and technology ,Type (model theory) ,Computer Science Applications ,Block design ,Base (group theory) ,Modeling and Simulation ,Scalability ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Low-density parity-check code ,computer ,Quantum ,Decoding methods ,computer.programming_language ,Mathematics - Abstract
Balanced incomplete block design (BIBD) offers an important way to construct non-homogeneous quantum low-density-parity-check (LDPC) codes of Calderbank-Shor-Steane (CSS) type. However, the rates of the quantum codes based on this method are limited to be $1-2/m$ approximately, where $m$ , the number of base blocks chosen from the associated BIBD, is even. We overcome this limitation by providing a rate scalable way to construct non-homogeneous quantum LDPC codes of CSS type. With our method, the rates of the resultant quantum codes are $1-2/m'$ , where $m'=m/e$ and $e\in \{1, 2\}$ . Note that here $m'$ can be odd . Thus, we double the rate range of the codes yielded from the existing strategies. Moreover, one can switch codes between the two rates flexibly adapting to various application scenarios.
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- 2021
35. Inhibition control impairments in adolescent smokers: electrophysiological evidence from a Go/NoGo study
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Yin, Junsen, Yuan, Kai, Feng, Dan, Cheng, Jiadong, Li, Yangding, Cai, Chenxi, Bi, Yanzhi, Sha, Shi, Shen, Xiaomin, Zhang, Ben, Xue, Ting, Qin, Wei, Yu, Dahua, Lu, Xiaoqi, and Tian, Jie
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- 2016
- Full Text
- View/download PDF
36. Lightweight Neural Network Architectures for Resource-Limited Devices
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Reed, April L., primary, Yang, Xiaokun, additional, and Sha, Shi, additional
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- 2022
- Full Text
- View/download PDF
37. Biological and clinical significance of flap endonuclease-1 in triple-negative breast cancer: Support of metastasis and a poor prognosis
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Xiaofang Che, Yunpeng Liu, Na Song, Lingyun Zhang, Xue Zeng, Sha Shi, Zu‑Ying Feng, Jing‑Lei Qu, Ke‑Zuo Hou, Lu Xu, Xiujuan Qu, and Yue‑E Teng
- Subjects
0301 basic medicine ,Cancer Research ,Lung Neoplasms ,Flap Endonucleases ,Triple Negative Breast Neoplasms ,Disease-Free Survival ,Metastasis ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Breast cancer ,Cell Line, Tumor ,Biomarkers, Tumor ,Medicine ,metastasis ,Animals ,Humans ,FEN1 ,Breast ,RNA-Seq ,Triple-negative breast cancer ,Mastectomy ,Cell Proliferation ,Neoplasm Staging ,Oncogene ,business.industry ,Cancer ,General Medicine ,Articles ,Cell cycle ,Middle Aged ,Actin cytoskeleton ,medicine.disease ,Prognosis ,Molecular medicine ,Xenograft Model Antitumor Assays ,030104 developmental biology ,Oncology ,Tissue Array Analysis ,030220 oncology & carcinogenesis ,triple negative breast cancer ,Gene Knockdown Techniques ,Lymphatic Metastasis ,Cancer research ,PLK4 ,Female ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Flap endonuclease‑1 (FEN1), a structure‑specific nuclease participating in DNA replication and repair processes, has been confirmed to promote the proliferation and drug resistance of tumor cells. However, the biological functions of FEN1 in cancer cell migration and invasion have not been defined. In the present study, using online database analysis and immunohistochemistry of the specimens, it was found that FEN1 expression was associated with a highly invasive triple‑negative breast cancer (TNBC) subtype in both breast cancer samples from the Oncomine database and from patients recruited into the study. Furthermore, FEN1 was an important biomarker of lymph node metastasis and poor prognosis in patients with TNBC. FEN1 promoted migration of TNBC cell lines and FEN1 knockdown reduced the number of spontaneous lung metastasis in vivo. Ingenuity Pathway Analysis of FEN1‑related transcripts in 198 patients with TNBC demonstrated that the polo‑like kinase family may be the downstream target of FEN1. PLK4 was further identified as a critical target of FEN1 mediating TNBC cell migration, by regulating actin cytoskeleton rearrangement. The results of the present study validate FEN1 as a therapeutic target in patients with TNBC and revealed a new role for FEN1 in regulating TNBC invasion and metastasis.
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- 2020
38. Cross-talk between the ER pathway and the lncRNA MAFG-AS1/miR-339-5p/ CDK2 axis promotes progression of ER+ breast cancer and confers tamoxifen resistance
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Zhi Li, Liang Feng, Jing Feng, Zichang Yang, Ti Wen, Kezuo Hou, Jiming Shen, Xu Han, Yuee Teng, Sha Shi, Lu Xu, and Lu Zhou
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MafG Transcription Factor ,Aging ,MAFG-AS1 ,Antineoplastic Agents, Hormonal ,tamoxifen resistance ,Estrogen receptor ,Breast Neoplasms ,Breast cancer ,breast cancer ,lncRNA ,Medicine ,Humans ,business.industry ,Competing endogenous RNA ,Cell growth ,Cyclin-Dependent Kinase 2 ,Cell Biology ,ceRNA ,Receptor Cross-Talk ,Cell cycle ,Middle Aged ,medicine.disease ,Repressor Proteins ,MicroRNAs ,Tamoxifen ,Receptors, Estrogen ,Tumor progression ,Apoptosis ,Drug Resistance, Neoplasm ,Cancer research ,Disease Progression ,cell cycle ,Female ,RNA, Long Noncoding ,Signal transduction ,business ,Research Paper ,Signal Transduction - Abstract
Hormone receptor-positive breast cancer accounts for around 75% of breast cancers. The estrogen receptor pathway promotes tumor progression and endocrine resistance. Recently, the cross-talk between the ER signaling pathway and cell cycle regulation has been identified. It is necessary to determine the underlying molecular mechanisms involved in the ER signaling pathway and find new target genes for prognosis and drug resistance in ER+ breast cancer. In this study, lncRNA MAFG-AS1 was shown to be up-regulated and associated with poor prognosis in ER+ breast cancer. Functionally, down-regulation of MAFG-AS1 could inhibit cell proliferation and promote apoptosis. In addition, MAFG-AS1 which contained an estrogen-responsive element could promote CDK2 expression by sponging miR-339-5p. Subsequently, MAFG-AS1 and CDK2 were found to be up-regulated in tamoxifen-resistant MCF-7 cells. Cross-talk between the ER signaling pathway and cell cycle conducted by MAFG-AS1 and CDK2 could promote tamoxifen resistance. In conclusion, our study indicated that estrogen-responsive lncRNA MAFG-AS1 up-regulated CDK2 by sponging miR-339-5p, which promoted ER+ breast cancer proliferation. Cross-talk between the ER signaling pathway and cell cycle suggested that lncRNA MAFG-AS1 is a potential biomarker and therapeutic target in ER+ breast cancer. CDK2 inhibitors may be applied to endocrine resistance therapy.
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- 2020
39. Physiological and Transcriptome Analyses Reveal the Response of Ammopiptanthus Mongolicus to Extreme Seasonal Temperature in Plateau Cold Desert Ecosystem
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Zimeng Yang, Yiying Liu, Hang Han, Xinyu Zhao, Siyu Chen, Guofang Li, Sha Shi, and Jinchao Feng
- Abstract
Ammopiptanthus mongolicus is an evergreen broad-leaved shrub living in plateau cold desert ecosystem, which with remarkable tolerance to diverse abiotic stresses. We measured the photosynthetic physiological indexes of A. mongolicus. under extreme seasonal climate in the field, and analyzed the transcriptome of its leaves. We found that the photosynthetic physiological indexes and gene expression at transcriptome level have significant characteristics when temperature changes. Under the low temperature condition, A. mongolicus. consumes excess light energy by increasing PSII non-regulatory energy dissipation Y (NO) at the physiological level. At the molecular level, it resists low temperature stress by changing photosynthesis, circadian rhythm and synthesis of unsaturated fatty acids, but its photosynthetic machinery is still damaged and photosynthesis is blocked. At the physiological level, A. mongolicus. regulates its own water content and improves the regulation of the PSII regulatory energy dissipation Y(NPQ) to consumes excess light energy and to adapt to high temperature stress. At the molecular level, A. mongolicus. protects itself from high temperature and strong light by using the LHCII of PSII to consume excess energy, continuously assembling and maintaining PSII, and changing the production of antioxidants and so on.
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- 2022
40. Prediction of RNA Secondary Structure Using Quantum-inspired Genetic Algorithms
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Le Yang, Sha Shi, Xin-Li Zhang, Yun-Jiang Wang, Wei Du, and Xian-Li Zhao
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0303 health sciences ,Computer science ,020207 software engineering ,02 engineering and technology ,Computational biology ,Biochemistry ,Nucleic acid secondary structure ,03 medical and health sciences ,Computational Mathematics ,0202 electrical engineering, electronic engineering, information engineering ,Genetics ,Molecular Biology ,Quantum ,030304 developmental biology - Abstract
Background: The prediction of RNA secondary structure using optimization algorithms is key to understand the real structure of an RNA. Evolutionary algorithms (EAs) are popular strategies for RNA secondary structure prediction. However, compared to most state-of-the-art software based on DPAs, the performances of EAs are a bit far from satisfactory. Objective: Therefore, a more powerful strategy is required to improve the performances of EAs when applied to the prediciton of RNA secondary structures. Methods: The idea of quantum computing is introduced here yielding a new strategy to find all possible legal paired-bases with the constraint of minimum free energy. The sate of a stem pool with size N is encoded as a population of QGA, which is represented by N quantum bits but not classical bits. The updating of populations is accomplished by so-called quantum crossover operations, quantum mutation operations and quantum rotation operations. Results: The numerical results show that the performances of traditional EAs are significantly improved by using QGA with regard to not only prediction accuracy and sensitivity but also complexity. Moreover, for RNA sequences with middle-short length, QGA even improves the state-of-art software based on DPAs in terms of both prediction accuracy and sensitivity. Conclusion: This work sheds an interesting light on the applications of quantum computing on RNA structure prediction.
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- 2020
41. Screening and identification of Chinese sorghum landraces for salt tolerance at germination and seedling stages
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Ping Lu, Li-Ge Bao, Min-Xuan Liu, Meng-Sha Shi, and Yue Xu
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chemistry.chemical_classification ,Soil salinity ,biology ,Salt (chemistry) ,Plant Science ,biology.organism_classification ,Sorghum ,Inner mongolia ,Crop ,Horticulture ,chemistry ,Dry weight ,Seedling ,Germination ,Agronomy and Crop Science ,Biotechnology - Abstract
The deterioration of soil salinization has caused great harm to modern agricultural production in the world. Sorghum is not only one of five main crops, but also an outstanding salt tolerant crop. The screening and identification of sorghum salt toletion of sorghum salt tolerance will be very important to the development and utilization of salinized land, increasing grain yield and maintaining sustainable agricultural development. In this experiment, 110 sorghum landraces were selected to test salt tolerance at germination (200 mmol L-1 NaCl treated) and seedling stages (100 mmol L-1 NaCl treated). The two germination indicators including the germination potential and the germination rate, as well as seven seedling indicators, including the relative chlorophyll content (SPAD), seedling length, root length, seedling fresh weight, seedling dry weight, root fresh weight, root dry weight were measured. The relative values of various indicators under salt stress were calculated, showing that the relative germination potential and relative germination rate of 110 sorghum landraces were 0 – 98.89% and 23.65 %– 101.79%, and The seven seedling indicators were 59.53% – 99.91%, 52.47% – 95.23%, 47.87% – 100.14%, 27.43% – 95.28%, 30.48% – 98.26%, 21.62% – 100.34%, 31.46% – 102.13%, respectively. Combined the membership function value analysis, principal component analysis with cluster analysis, the salt tolephyll content (SPAD), seedling length, root length, seedling fresh weight, seedling dry weight, root fresh weight, root dry weight were measured. The relative values of various indicators under salt stress were calculated, showing that the relative germination potential and relative germination rate of 110 sorghum landraces were 0 – 98.89% and 23.65 %– 101.79%, and The seven seedling indicators were 59.53% – 99.91%, 52.47% – 95.23%, 47.87% – 100.14%, 27.43% – 95.28%, 30.48% – 98.26%, 21.62% – 100.34%, 31.46% – 102.13%, respectively. Combined the membership function value analysis, principal component analysis with cluster analysis, the salt tolerance ability of the 110 landraces at germination stage and seedling stage was comprehensively evaluated and the 110 landraces were clustered into four groups. A batch of sorghum landraces with salt tolerance at germination and seedling stages were identified, especially ten landraces, including Chaoyangbangchui (00003011) from Inner Mongolia and the Baidazimao (00001081) from Beijing showed high salt tolerance, which can be used in further research. There was no significant correlation in salt toleghum landraces with salt tolerance at germination and seedling stages were identified, especially ten landraces, including Chaoyangbangchui (00003011) from Inner Mongolia and the Baidazimao (00001081) from Beijing showed high salt tolerance, which can be used in further research. There was no significant correlation in salt tolerance between the germination stage and the seedling stage. Principal component analysis results indicated that seedling dry weight and root fresh weight can be used as indicators for the evaluation of salt tolerance of a large number of sorghum landraces at seedling stage.
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- 2020
42. MiR-891a-5p as a prognostic marker and therapeutic target for hormone receptor-positive breast cancer
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Yuee Teng, Lu Xu, Sha Shi, Lijie He, Zhi Li, Zhiqiang Zhang, Kezuo Hou, Xiaonan Shi, Jin Wang, and Xiujuan Qu
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,medicine.drug_class ,miR-383-5p ,ADAM10 ,Metastasis ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Downregulation and upregulation ,Internal medicine ,microRNA ,medicine ,metastasis ,Gene silencing ,skin and connective tissue diseases ,miR-891a-5p ,business.industry ,medicine.disease ,microRNAs ,030104 developmental biology ,Estrogen ,Hormone receptor ,030220 oncology & carcinogenesis ,prognosis ,business ,Research Paper - Abstract
Background: Breast cancer is one of the most frequent malignant tumors worldwide, with 1.67 million newly-diagnosed cases and 522,000 deaths each year. Therefore, seeking the novel biomarkers and therapeutic targets that contribute to postoperative recurrence and metastasis in patients with breast cancer is emerging and facilitates the development of innovative therapeutics. Methods: Retrieving the dataset of patients with hormone receptor (HR)-positive breast cancers from Gene Expression Omnibus (GEO) and collecting the data from the patients with HR-positive breast cancers enrolled in the First Affiliated Hospital of China Medical University are so as to identify the miRNAs associated with metastasis and distant metastasis-free survival (DMFS). Then MTT and Transwell migration assays were used to validate the effect of miRNAs on cell proliferation and migration of estrogen receptor-positive breast cancer T47D and MCF7 cells in vitro, respectively. Results: From GSE59829 dataset, the miRNA expression levels of miR-891a-5p, miR-383-5p and miR-1295a were significantly downregulated while the levels of miR-128-3p, miR-661 and miR-296-3p were significantly upregulated in breast cancers from patients with metastasis as compared to the matched non-metastatic group. Moreover, low expression levels of miR-891a-5p, miR-383-5p and miR-1295a or high expression levels of miR-128-3p, miR-661 and miR-296-3p were respectively associated with low DMFS in patients with breast cancer. Our clinical cohort study supported that the levels of miR-891a-5p, miR-383-5p and miR-1295a were significantly lower in breast cancers from the metastasis group when compared with non-metastatic group. However, there is no significant difference with regard to the levels of miR-128-3p, miR-661 and miR-296-3p in breast cancer between these two groups. Moreover, low expression levels of miR-891a-5p and miR-383-5p but not miR-1295a in breast cancer were significantly associated with low DMFS in patients, implying that the expression of miR-891a-5p and miR-383-5p were the potential prognosis markers for metastatic human breast cancers. Further investigation disclosed that miR-891a-5p but not miR-383-5p restrained both proliferation and migration of T47D and MCF7 cells. In silico analysis of miRNAs target gene through online computational algorithms revealed that A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is the downstream target for miR-891a-5p. Further study confirmed that miR-891a-5p impeded ADAM10 expression by directly binding to its 3'UTR, leading to the inhibition of breast cancer cells proliferation and migration. Moreover, silencing ADAM10 inhibited T47D and MCF7 cells growth and migration. Conclusion: miR-891a-5p is the vital prognostic marker for HR-positive breast cancer. In addition, miR-891a-5p and miR-383-5p are the potential targets for HR-positive breast cancer therapeutics.
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- 2020
43. Prognostic Value and Influence of Receptor Conversion on Treatment Regimen in Metastatic Breast Cancer at the First Time of Recurrence
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Dongni Wang, Jing Shi, Jing Feng, Jiming Shen, Xu Han, Sha Shi, Yu Shi, Mingfang Sun, Lu Xu, Yuee Teng, Xiaoyi Mi, Lei Zhao, and Qiaochu Wei
- Subjects
Adult ,Oncology ,Cancer Research ,medicine.medical_specialty ,Receptor Status ,Receptor, ErbB-2 ,Biopsy ,medicine.medical_treatment ,Estrogen receptor ,Breast Neoplasms ,Kaplan-Meier Estimate ,Disease-Free Survival ,Breast cancer ,Internal medicine ,Progesterone receptor ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Metastasis ,Receptor ,Aged ,Chemotherapy ,business.industry ,Treatment regimen ,Hematology ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Metastatic breast cancer ,Survival Rate ,Receptors, Estrogen ,Female ,Neoplasm Recurrence, Local ,Receptors, Progesterone ,business - Abstract
Purpose: At the first time of metastatic breast cancer recurrence, conversion of the receptors status may occur between primary lesions and metastatic lesions, including the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Whether the decision of the treatment regimen is based on the primary receptor status or that of metastatic lesions is still unclear. Methods: This study enrolled 411 female patients with a diagnosis of metastatic breast cancer at the first time of recurrence to explore the influence of receptor conversion on prognosis prediction and treatment regimen of patients with metastatic breast cancer. Results: ER and PR changes from negative to positive are both prognostic factors for patients with breast cancer. Patients receiving endocrine therapy showed a better survival after recurrence than those using chemotherapy alone in the ER or PR Prim– Met+ subgroup. Patients in the HER2 Prim– Met+ subgroup using HER2-targeted therapy in multilines showed a post-recurrence survival advantage. In the bone re-biopsy subgroup, the PR change from positive to negative appeared to be more frequent than at other re-biopsy sites. Conclusions: Patients with metastatic breast cancer should perform re-biopsy to clarify the receptor status of the first metastatic lesions, which may provide clinicians valuable evidence to conduct treatments with higher precision.
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- 2020
44. Etiological and epidemiological features of acute respiratory infections in China
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Xiang Ren, Aili Cui, Lili Ren, Xinhua Wang, Mengyang Liu, Qing-Bin Lu, Tao Jiang, Lu-Sha Shi, An-Ran Zhang, Yang Yang, Sheng-Hong Lin, Yingle Liu, Zuo-Sen Yang, Jianguo Wu, Zhongjie Li, Xiao-Ai Zhang, Mengfeng Li, Jun Li, Wei Liu, Cui-Hong Zhang, Yu-Liang Zhu, Zhenghong Yuan, Simon I. Hay, George F. Gao, Huaiqi Jing, Liu-Yu Huang, Yu Chen, Shengjie Lai, Weizhong Yang, Yi-Fei Wang, Hai-Yang Zhang, Liping Wang, Zhi-Gang Yi, Xin Wang, Luzhao Feng, Li-Qun Fang, Yu Wang, Lei Meng, Zhijie Zhang, Michael P. Ward, Yang Yuan, Shiwen Zhao, Xiao Chen, and Wenbo Xu
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Mycoplasma pneumoniae ,Adolescent ,Epidemiology ,Science ,General Physics and Astronomy ,medicine.disease_cause ,Article ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,Internal medicine ,Streptococcus pneumoniae ,medicine ,Humans ,Prospective Studies ,Child ,Respiratory Tract Infections ,Acute respiratory tract infection ,Respiratory tract diseases ,Multidisciplinary ,Bacteria ,Respiratory tract infections ,business.industry ,Infant ,Bacterial Infections ,General Chemistry ,medicine.disease ,Pneumonia ,Virus Diseases ,Child, Preschool ,Viruses ,Etiology ,Infectious diseases ,Female ,Seasons ,Rhinovirus ,business - Abstract
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children, China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.
- Published
- 2021
45. Antioxidant interventions in autism spectrum disorders: A meta-analysis
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Yi-Ying Liu, Yang Du, Sha Shi, Zi-Meng Yang, and Yong Cheng
- Subjects
medicine.medical_specialty ,Autism Spectrum Disorder ,Psychological intervention ,Irritability ,Placebo ,Antioxidants ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Biological Psychiatry ,Randomized Controlled Trials as Topic ,Pharmacology ,business.industry ,Publication bias ,medicine.disease ,Acetylcysteine ,Oxidative Stress ,Autism spectrum disorder ,Meta-analysis ,Autism ,medicine.symptom ,Stereotyped Behavior ,business - Abstract
Background Autism spectrum disorder (ASD) might be associated with oxidative stress, and antioxidants are commonly used in the treatment of young people with ASD. However, the evidence about the effectiveness of these interventions remains debatable. We performed a meta-analysis to evaluate the effect of antioxidants on the symptoms of patients with autism. Methods Data sources: PubMed and Web of Science databases. Study selection: We selected placebo-controlled, double-blind, randomized clinical trials published until February 2021 to evaluate the efficacy of antioxidant interventions on ASD. Data analysis: Aberrant Behavior Checklist (ABC), Repetitive Behavior Scale-Revised (RBS), Social Responsiveness Scale (SRS), Developmental Behavior Checklist (DBC) and Clinical Global Impressions Severity scale (CGI S) were used to evaluate the 22 different symptom outcomes. The Hedges-adjusted g value was used to estimate the effect of each dietary intervention relative to the placebo. Results In this meta-analysis, we examined 13 double-blind randomized clinical trials, comprising a total of 570 patients with ASD: 293 in the intervention group and 277 in the placebo group. Antioxidants (N-acetylcysteine (NAC), other antioxidants) are more effective than placebos in improving the irritability among symptoms in the ABC and communication disturbance symptoms in the DBC. There was a good trend of improvement in the stereotypic behavior symptoms in the ABC. Treatment with NAC antioxidants showed a good trend of improvement in irritability in the ABC and symptoms of hyperactivity. The effect size was small, and there was a low risk of statistical heterogeneity and publication bias. Limitations: The number of studies in this meta-analysis was small and the sample size was small. Conclusion This meta-analysis suggests that antioxidant intervention has a potential role in the management of some symptoms in patients with ASD, and indicates the feasibility of using antioxidants to treat autism in the future.
- Published
- 2021
46. Etiological, epidemiological, and clinical features of acute diarrhea in China
- Author
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Xinhua Wang, Zhenghong Yuan, Mengyang Liu, Huaiqi Jing, Xiao-Ai Zhang, Jianguo Wu, Shengjie Lai, Xiao Chen, Qing-Bin Lu, Zhongjie Li, Liping Wang, Simon I. Hay, Liu-Yu Huang, Jun Li, Zhi-Gang Yi, Cui-Hong Zhang, Weizhong Yang, Yi-Fei Wang, Yu Chen, George F. Gao, Zuo-Sen Yang, Aili Cui, Shiwen Zhao, Wei Liu, Lu-Sha Shi, Hai-Yang Zhang, Lei Meng, Xiang Ren, Wenbo Xu, Shi-Xia Zhou, Xin Wang, Yu-Liang Zhu, Yingle Liu, Mengfeng Li, Sheng-Hong Lin, Mengjie Geng, and Li-Qun Fang
- Subjects
Rotavirus ,0301 basic medicine ,Epidemiology ,General Physics and Astronomy ,medicine.disease_cause ,0302 clinical medicine ,Salmonella ,Shigella ,030212 general & internal medicine ,Child ,Escherichia coli Infections ,Caliciviridae Infections ,Multidisciplinary ,biology ,Vibrio parahaemolyticus ,Age Factors ,Middle Aged ,Gastroenteritis ,Diarrhea ,Child, Preschool ,Salmonella Infections ,Pathogens ,medicine.symptom ,Adult ,China ,medicine.medical_specialty ,Adolescent ,Science ,030106 microbiology ,Rotavirus Infections ,Article ,General Biochemistry, Genetics and Molecular Biology ,Astrovirus ,Applied microbiology ,Young Adult ,03 medical and health sciences ,Internal medicine ,Escherichia coli ,medicine ,Humans ,business.industry ,Norovirus ,General Chemistry ,biology.organism_classification ,Vibrio Infections ,Etiology ,business - Abstract
National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Diarrheagenic Escherichia coli and nontyphoidal Salmonella are the two leading bacterial pathogens, followed by Shigella and Vibrio parahaemolyticus. Patients aged, Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.
- Published
- 2021
47. A Novel Application of Probabilistic Teleportation: p-Rabin Quantum Oblivious Transfer of a Qubit
- Author
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MeiLing Zhang, QingJi Zheng, YuanHua Liu, Jin Li, and Sha Shi
- Subjects
TheoryofComputation_MISCELLANEOUS ,Security analysis ,Theoretical computer science ,Physics and Astronomy (miscellaneous) ,Oblivious transfer ,010308 nuclear & particles physics ,Computer science ,General Mathematics ,Data_CODINGANDINFORMATIONTHEORY ,Quantum Physics ,01 natural sciences ,Computer Science::Robotics ,Computer Science::Emerging Technologies ,Encoding (memory) ,Qubit ,0103 physical sciences ,State (computer science) ,Computer Science::Data Structures and Algorithms ,010306 general physics ,Protocol (object-oriented programming) ,Realization (systems) ,Quantum ,Computer Science::Cryptography and Security - Abstract
So far, all existing quantum oblivious transfer protocols focused on realization of the oblivious transfer of a classical bit or classical bit-string. In this paper, p-Rabin quantum oblivious transfer of a qubit protocol is achieved by using a probabilistic teleportation protocol. As the probabilistic teleportation protocol is able to transfer an (un)known pure state with a certain probability, this feature makes the probabilistic teleportation protocol well fit for Rabin oblivious transfer. Here, this is the first time that the concept of qubit oblivious transfer is presented. Furthermore, p-Rabin quantum oblivious transfer of a qubit protocol can also be used for oblivious of a bit by encoding classical bit with two pre-agreed orthogonal states. Finally, security analysis shows that the protocol satisfies the security requirements of oblivious transfer, and what’s more, the discussion of relationship with no-go theorem demonstrates that the probabilistic teleportation protocol is able to evade the no-go theorem.
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- 2019
48. De novo transcriptome sequencing and identification of genes related to salt and PEG stress in Tetraena mongolica Maxim
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Ningmei Chen, Junqing He, Sha Shi, Buerbatu Song, Jinchao Feng, Yijun Zhou, Shuai Tang, and Xiaojing Xu
- Subjects
0106 biological sciences ,0301 basic medicine ,Genetics ,Ecology ,biology ,Physiology ,Plant physiology ,RNA ,Forestry ,Plant Science ,biology.organism_classification ,01 natural sciences ,Transcriptome Sequencing ,Transcriptome ,03 medical and health sciences ,030104 developmental biology ,Zygophyllaceae ,Gene ,Transcription factor ,Tetraena mongolica ,010606 plant biology & botany - Abstract
The first transcriptome analyses of Tetraena mongolica provided 224,618 Unigenes and identified the genes that were differentially expressed under salt and drought conditions, giving some insights into the unique adaptive capacity of this relic plant. Tetraena mongolica Maxim, the only member of the Tetraena genus in the Zygophyllaceae, is endemic to the northwest of China. As one of the relic shrubs of the Paleo-Mediterranean flora, T. mongolica plays a key role in preserving the local ecological environment. To investigate its good adaptability in desert, we studied the transcriptome of T. mongolica under NaCl and PEG6000 stresses. Three libraries were constructed from a mixture of seedlings and mature plants of T. mongolica, and the de novo transcriptome was sequenced using an Illumina HiSeq 4000. Approximately 218.15 million clean reads were assembled de novo into 383,612 transcripts, and 116,027 All-Unigenes were identified. By aligning All-Unigene sequences against the NR database, we found that most of the All-Unigenes had very low matches with the sequences from other plants. A total of 21,112 SSRs and 6 types of SNP variants were identified. The RNA-Seq data revealed 60 transcription factor (TF) families with 3163 genes in total. Six libraries were constructed from the separate control or stressed seedlings, and the transcriptome was sequenced using a BGISEQ-500 platform. There are 1105 and 1383 differentially expressed genes (DEGs) with 42 and 54 TFs under NaCl and PEG6000 treatment, respectively. The genes that were putatively involved in salt and osmotic stresses were searched and analyzed. Quantitative reverse transcription PCR (qRT-PCR) showed that DEG expression profiles were consistent with those from RNA-seq (RNA sequencing). Overall, this study provides new insights into the molecular mechanisms that control salt and drought stress responses in T. mongolica.
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- 2019
49. FEN1 mediates miR‐200a methylation and promotes breast cancer cell growthviaMET and EGFR signaling
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Xue Zeng, Na Zhang, Lu Xu, Kezuo Hou, Yuee Teng, Jing Feng, Yunpeng Liu, Lingyun Zhang, Zhigang Guo, Jiawen Xiao, Chen‑Yang Zhao, Sha Shi, Xiaofang Che, and Xiujuan Qu
- Subjects
0301 basic medicine ,biology ,Cancer ,Methylation ,medicine.disease ,Biochemistry ,DNA methyltransferase ,Proliferating cell nuclear antigen ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Tumor progression ,microRNA ,Genetics ,medicine ,Cancer research ,biology.protein ,Hepatocyte growth factor ,Epidermal growth factor receptor ,Molecular Biology ,030217 neurology & neurosurgery ,Biotechnology ,medicine.drug - Abstract
Flap endonuclease 1 (FEN1) is recognized as a pivotal factor in DNA replication, long-patch excision repair, and telomere maintenance. Excessive FEN1 expression has been reported to be closely associated with cancer progression, but the specific mechanism has not yet been explored. In the present study, we demonstrated that FEN1 promoted breast cancer cell proliferation via an epigenetic mechanism of FEN1-mediated up-regulation of DNA methyltransferase (DNMT)1 and DNMT3a. FEN1 was proved to interact with DNMT3a through proliferating cell nuclear antigen (PCNA) to suppress microRNA (miR)-200a-5p expression mediated by methylation. Furthermore, miR-200a-5p was identified to repress breast cancer cell proliferation by inhibiting the expression of its target genes, hepatocyte growth factor (MET), and epidermal growth factor receptor (EGFR). Overall, our data surprisingly demonstrate that FEN1 promotes breast cancer cell growth via the formation of FEN1/PCNA/DNMT3a complex to inhibit miR-200a expression by DNMT-mediated methylation and to recover the target genes expression of miR-200a, MET, and EGFR. The novel epigenetic mechanism of FEN1 on proliferation promotion provides a significant clue that FEN1 might serve as a predictive biomarker and therapeutic target for breast cancer.-Zeng, X., Qu, X., Zhao, C., Xu, L., Hou, K., Liu, Y., Zhang, N., Feng, J., Shi, S., Zhang, L., Xiao, J., Guo, Z., Teng, Y., Che, X. FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling.
- Published
- 2019
50. Prediction of the RNA Secondary Structure Using a Multi-Population Assisted Quantum Genetic Algorithm
- Author
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Xin-Li Zhang, Wei Du, Sha Shi, Le Yang, Xian-Li Zhao, and Yun-Jiang Wang
- Subjects
0303 health sciences ,Base Sequence ,business.industry ,Computer science ,030305 genetics & heredity ,Evolutionary algorithm ,Nucleic acid secondary structure ,03 medical and health sciences ,Software ,Operator (computer programming) ,Genetic algorithm ,Genetics ,RNA ,Quantum algorithm ,Sensitivity (control systems) ,business ,Algorithm ,Algorithms ,Genetics (clinical) ,030304 developmental biology ,Quantum computer - Abstract
Quantum-inspired genetic algorithms (QGAs) were recently introduced for the prediction of RNA secondary structures, and they showed some superiority over the existing popular strategies. In this paper, for RNA secondary structure prediction, we introduce a new QGA named multi-population assisted quantum genetic algorithm (MAQGA). In contrast to the existing QGAs, our strategy involves multi-populations which evolve together in a cooperative way in each iteration, and the genetic exchange between various populations is performed by an operator transfer operation. The numerical results show that the performances of existing genetic algorithms (evolutionary algorithms [EAs]), including traditional EAs and QGAs, can be significantly improved by using our approach. Moreover, for RNA sequences with middle-short length, the MAQGA improves even this state-of-the-art software in terms of both prediction accuracy and sensitivity.
- Published
- 2019
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