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4. Real-world effectiveness of original BNT162b2 mRNA COVID-19 against symptomatic Omicron infection among children 5–11 years of age in Brazil: A prospective test-negative design study

Author

Rodrigues, Cristina de Oliveira, Spinardi, Julia, Rosa, Regis Goulart, Falavigna, Maicon, de Souza, Emanuel Maltempi, Manfio, Josélia Larger, de Souza, Ana Paula, de Araujo, Cintia Laura Pereira, Cohen, Mírian, Barbosa, Gynara Rezende Gonzalez do Valle, Silva, Fernanda Kelly Romeiro, Sganzerla, Daniel, da Silva, Mariana Motta Dias, Ferreira, Diogo, Kunkel, Nicolas Taciano, Camargo, Nathan Iori, Sarturi, Jean Carlos, Guilhem, Márcia Cristina, de Oliveira, Jaqueline Carvalho, Lopes, Caroline Cardoso, Widmar, Fernanda, Barufi, Letícia Killes, da Silva, Gabrielle Nunes, Gradia, Daniela Fiori, Brandalize, Ana Paula Carneiro, Royer, Carla Adriane, Luiz, Rafael Messias, Baura, Valter Antonio, Abreu, Hellen, Poitevin, Carolina Gracia, Kucharski, Gabriela Almeida, Pedrotti, Fernando, Valluri, Srinivas Rao, Srivastava, Amit, Julião, Viviane Wal, Melone, Olga Chameh, Allen, Kristen E., Kyaw, Moe H, Castillo, Graciela del Carmen Morales, and McLaughlin, John M

Published
2024
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5. Reply to the letter “Understanding lactate and its clearance during extracorporeal membrane oxygenation for supporting refractory cardiogenic shock patients”

Author

Scolari, Fernando Luís, Schneider, Daniel, Fogazzi, Débora Vacaro, Gus, Miguel, Rover, Marciane Maria, Bonatto, Marcely Gimenes, de Araújo, Gustavo Neves, Zimerman, André, Sganzerla, Daniel, Goldraich, Lívia Adams, Teixeira, Cassiano, Friedman, Gilberto, Polanczyk, Carisi Anne, Rohde, Luis Eduardo, Rosa, Regis Goulart, and Wainstein, Rodrigo Vugman

Published
2023
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6. BNT162b2 mRNA COVID-19 against symptomatic Omicron infection following a mass vaccination campaign in southern Brazil: A prospective test-negative design study

Author

Rosa, Regis Goulart, Falavigna, Maicon, Manfio, Josélia Larger, de Araujo, Cintia Laura Pereira, Cohen, Mírian, do Valle Barbosa, Gynara Rezende Gonzalez, de Souza, Ana Paula, Romeiro Silva, Fernanda Kelly, Sganzerla, Daniel, da Silva, Mariana Motta Dias, Ferreira, Diogo, de Oliveira Rodrigues, Cristina, de Souza, Emanuel Maltempi, de Oliveira, Jaqueline Carvalho, Gradia, Daniela Fiori, Brandalize, Ana Paula Carneiro, Royer, Carla Adriane, Luiz, Rafael Messias, Kucharski, Gabriela Almeida, Pedrotti, Fernando, Valluri, Srinivas Rao, Srivastava, Amit, Julião, Viviane Wal, Melone, Olga Chameh, Allen, Kristen E., Kyaw, Moe H., Spinardi, Julia, del Carmen Morales Castillo, Graciela, and McLaughlin, John M.

Published
2023
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7. Higher frequency of interstate over international transmission chains of SARS-CoV-2 virus at the Rio Grande do Sul - Brazil state borders

Author

Dezordi, Filipe Zimmer, primary, Silva Junior, José Valter Joaquim, additional, Ruoso, Terimar Facin, additional, Batista, Angela Giovana, additional, Fonseca, Pedro Mesquita, additional, Salvato, Richard Steiner, additional, Gregianini, Tatiana Schäffer, additional, Lopes, Thaísa Regina Rocha, additional, Flores, Eduardo Furtado, additional, Weiblen, Rudi, additional, Brites, Patricia Chaves, additional, Silva, Mônica de Medeiros, additional, da Rocha, João Batista Teixeira, additional, Barbosa, Gustavo de Lima, additional, Machado, Lais Ceschini, additional, da Silva, Alexandre Freitas, additional, Paiva, Marcelo Henrique Santos, additional, Bezerra, Matheus Filguera, additional, Campos, Tulio de Lima, additional, Gräf, Tiago, additional, Sganzerla, Daniel Angelo, additional, Loreto, Elgion Lucio da Silva, additional, and Wallau, Gabriel da Luz, additional

Published
2024
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8. Long-Term Mortality and Health-Related Quality of Life After Continuous Versus Intermittent Renal Replacement Therapy in ICU Survivors: A Secondary Analysis of the Quality of Life After ICU Study.

Author

Siqueira Santos, Mariana Martins, Sganzerla, Daniel, Pereira, Isabel Jesus, Rosa, Regis Goulart, Granja, Cristina, Teixeira, Cassiano, and Azevedo, Luís

Subjects
*RENAL replacement therapy, *INTENSIVE care units, *QUALITY of life, *ACUTE kidney failure, *HOSPITAL admission & discharge
Abstract

Purpose: We assessed long-term outcomes in intensive care unit (ICU) survivors with acute kidney injury (AKI) submitted to intermittent or continuous renal replacement therapy (RRT) for comparisons between groups. Methods: The multicenter prospective cohort study included 195 adult ICU survivors with an ICU stay >72 h in 10 ICUs that had at least one episode of AKI treated with intermittent RRT (IRRT) or continuous RRT (CRRT) during ICU stay. The main outcomes were mortality and health-related quality of life (HRQoL). Hospital readmissions and physical dependence were also assessed. Results: Regarding RRT, 83 (42.6%) patients received IRRT and 112 (57.4%) received CRRT. Despite the similarity regarding sociodemographic characteristics, pre-ICU state of health and type of admission between groups, the risk of death (23.5% vs 42.7%; P <.001), the prevalence of sepsis (60.7%) and acute respiratory distress syndrome (17%) were higher at ICU admission among CRRT patients. The severity of critical illness was higher among CRRT patients, regarding the need for mechanical ventilation (75.0% vs 50.6%, P =.002) and vasopressors (91.1% vs 63.9%, P <.001). One year after ICU discharge, 67 of 195 ICU survivors died (34.4%) and, after adjustment for confounders, there were no significant differences in mortality when comparing IRRT and CRTT patients (34.9% vs 33.9%; P =.590), on HRQoL in both physical (41.9% vs 42.2%; P =.926) and mental dimensions (57.6% vs 56.6%; P =.340), and on the number of hospital readmissions and physical dependence. Conclusions: Our study suggests that among ICU survivors RRT modality (IRRT vs CRRT) in the ICU does not impact long-term outcomes after ICU discharge. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Brazilian Translation, Cross-Cultural Adaptation, Validity, and Reliability of the EMpowerment of PArents in THe Intensive Care 30 Questionnaire to Measure Parental Satisfaction in PICUs

Author

Lessa, Alessandra D., Cabral, Felipe C., Tonial, Cristian T., Costa, Caroline A. D., Andrades, Gabriela R. H., Crestani, Francielly, Einloft, Paulo R., Bruno, Francisco, Sganzerla, Daniel, Matte, Maria C. C., Fiori, Humberto H., Latour, Jos M., and Garcia, Pedro Celiny R.

Published
2020
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11. Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study

Author

Scolari, Fernando Luís, Schneider, Daniel, Fogazzi, Débora Vacaro, Gus, Miguel, Rover, Marciane Maria, Bonatto, Marcely Gimenes, de Araújo, Gustavo Neves, Zimerman, André, Sganzerla, Daniel, Goldraich, Lívia Adams, Teixeira, Cassiano, Friedman, Gilberto, Polanczyk, Carisi Anne, Rohde, Luis Eduardo, Rosa, Regis Goulart, and Wainstein, Rodrigo Vugman

Published
2020
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12. Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study)

Author

Giordani, Natalia Elis, Robinson, Caroline Cabral, Westphal, Glauco Adrieno, Rosa, Regis Goulart, Sganzerla, Daniel, Cavalcanti, Alexandre Biasi, Machado, Flávia Ribeiro, Azevedo, Luciano Cesar Pontes, Bozza, Fernando Augusto, Teixeira, Cassiano, de Andrade, Joel, Franke, Cristiano Augusto, Guterres, Cátia Moreira, Madalena, Itiana Cardoso, Rohden, Adriane Isabel, da Silva, Sabrina Souza, Andrighetto, Luiza Vitelo, Rech, Gabriela Soares, Gimenes, Bruna dos Passos, Hammes, Luciano Serpa, Pontes, Daniela Ferreira Salomão, Meade, Maureen O., and Falavigna, Maicon

Published
2020
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13. Early and Late Mortality Following Discharge From the ICU: A Multicenter Prospective Cohort Study*

Author

Rosa, Regis G., Falavigna, Maicon, Robinson, Caroline C., Sanchez, Evelin C., Kochhann, Renata, Schneider, Daniel, Sganzerla, Daniel, Dietrich, Camila, Barbosa, Mirceli G., de Souza, Denise, Rech, Gabriela S., dos Santos, Rosa da R., da Silva, Alice P., Santos, Mariana M., Dal Lago, Pedro, Sharshar, Tarek, Bozza, Fernando A., and Teixeira, Cassiano

Published
2020
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14. Impact of vertical positioning on lung aeration among mechanically ventilated intensive care unit patients: a randomized crossover clinical trial.

Author

Neves, Douglas, Marques Filho, Paulo Ricardo, da Silva Townsend, Raquel, dos Santos Rodrigues, Cristiano, Tagliari, Luciana, Cordeiro Madeira, Laura, Fensterseifer Mattioni, Mariana, Ferreira de Camillis, Márcio Luiz, Soares Leães, Clarissa Garcia, Stormovski de Andrade, Juliana Mara, Cabral Robinson, Caroline, Sganzerla, Daniel, Drehmer, Laura, Madruga da Costa, Denis Fernandes, Sant'Ana Machado, André, Goulart Rosa, Regis, and Dal Lago, Pedro

Subjects
ARTIFICIAL respiration, HEMODYNAMICS, RESPIRATORY mechanics, ADULTS, VENTILATION
Abstract

Objective: To assess the impact of different vertical positions on lung aeration in patients receiving invasive mechanical ventilation. Methods: An open-label randomized crossover clinical trial was conducted between January and July 2020. Adults receiving invasive mechanical ventilation for > 24 hours and < 7 days with hemodynamic, respiratory and neurological stability were randomly assigned at a 1:1 ratio to the sitting position followed by passive orthostasis condition or the passive orthostasis followed by the sitting position condition. The primary outcome was lung aeration assessed using the lung ultrasound score (score ranges from 0 [better] to 36 [worse]). Results: A total of 186 subjects were screened; of these subjects, 19 were enrolled (57.8% male; mean age, 73.2 years). All participants were assigned to receive at least one verticalization protocol. Passive orthostasis resulted in mean lung ultrasound scores that did not differ significantly from the sitting position (11.0 versus 13.7; mean difference, -2.7; [95%CI -6.1 to 0.71; p = 0.11). Adverse events occurred in three subjects in the passive orthostasis group and in one in the sitting position group (p = 0.99). Conclusion: This analysis did not find significant differences in lung aeration between the sitting and passive orthostasis groups. A randomized crossover clinical trial assessing the impact of vertical positioning on lung aeration in patients receiving invasive mechanical ventilation is feasible. Unfortunately, the study was interrupted due to the need to treat COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Desempenho do Escore SHARPEN e do Índice de Comorbidade de Charlson para Predição de Mortalidade durante a Internação Hospitalar e após a Alta na Endocardite Infecciosa

Author

Alves, Sofia Giusti, primary, Pivatto, Fernando, additional, Filippini, Filippe Barcellos, additional, Dannenhauer, Gustavo Paglioli, additional, Seroiska, Gabriel, additional, Bischoff, Helena Marcon, additional, Birk, Luiz Felipe Schmidt, additional, Terra, Diego Henrique, additional, Sganzerla, Daniel, additional, and Miglioranza, Marcelo Haertel, additional

Published
2023
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16. Impacto do posicionamento vertical na aeração pulmonar em pacientes de unidades de terapia intensiva ventilados mecanicamente: um estudo clínico transversal randomizado

Author

Neves, Douglas, primary, Marques, Paulo Ricardo, additional, Townsend, Raquel da Silva, additional, Rodrigues, Cristiano dos Santos, additional, Tagliari, Luciana, additional, Madeira, Laura Cordeiro, additional, Mattioni, Mariana Fensterseifer, additional, Camillis, Márcio Luiz Ferreira de, additional, Leães, Clarissa Garcia Soares, additional, Andrade, Juliana Mara Stormovski de, additional, Robinson, Caroline Cabral, additional, Sganzerla, Daniel, additional, Drehmer, Laura, additional, Costa, Denis Fernandes Madruga da, additional, Machado, André Sant'Ana, additional, Rosa, Regis Goulart, additional, and Lago, Pedro Dal, additional

Published
2023
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19. Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)

Author

Sganzerla, Daniel, Teixeira, Cassiano, Robinson, Caroline Cabral, Kochhann, Renata, Santos, Mariana Martins Siqueira, de Moura, Rafaela Moraes, Barbosa, Mirceli Goulart, da Silva, Daiana Barbosa, Ribeiro, Tarissa, Eugênio, Cláudia, Schneider, Daniel, Mariani, Débora, Jeffman, Rodrigo Wiltgen, Bozza, Fernando, Cavalcanti, Alexandre Biasi, Azevedo, Luciano Cesar Pontes, Machado, Flávia Ribeiro, Salluh, Jorge Ibrain, Pellegrini, José Augusto Santos, Moraes, Rafael Barberena, Damiani, Lucas Petri, da Silva, Nilton Brandão, Falavigna, Maicon, and Rosa, Regis Goulart

Published
2018
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20. More than the tip of the iceberg: association between disabilities and inability to attend a clinic-based post-ICU follow-up and how it may impact on health inequalities

Author

Rosa, Regis Goulart, Kochhann, Renata, Berto, Paula, Biason, Livia, Maccari, Juçara Gasparetto, De Leon, Patrícia, Dutra, Francine, da Silva, Sâmia Faria, Sganzerla, Daniel, Schneider, Daniel, Cardoso, Paulo Ricardo, Gomes, Frederico Klein, Machado, Vitória Homem, Medeiros, Gregory, Tonietto, Tulio Frederico, Tagliari, Luciana, Mattioni, Mariana, Anzolin, Luisa, Oliveira, Maicon, de Andrade, Juliana Mara Stormovski, Falavigna, Maicon, Robinson, Caroline Cabral, and Teixeira, Cassiano

Published
2018
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21. BNT162b2 against COVID-19 in Brazil using a test-negative design: Study protocol and statistical analysis plan

Author

Goulart Rosa, Regis, primary, Spinardi, Julia, additional, Allen, Kristen E., additional, Manfio, Josélia, additional, de Araujo, Cintia Laura Pereira, additional, Cohen, Mírian, additional, Robinson, Caroline Cabral, additional, Sganzerla, Daniel, additional, Ferreira, Diogo, additional, de Souza, Emanuel Maltempi, additional, de Oliveira, Jaqueline Carvalho, additional, Gradia, Daniela Fiori, additional, Brandalize, Ana Paula Carneiro, additional, Kucharski, Gabriela Almeida, additional, Pedrotti, Fernando, additional, Rodrigues, Cristina de Oliveira, additional, Kyaw, Moe H., additional, Castillo, Graciela del Carmen Morales, additional, Srivastava, Amit, additional, McLaughlin, John M., additional, and Falavigna, Maicon, additional

Published
2022
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22. IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva

Author

Tomazini, Bruno M, Nassar Jr, Antonio Paulo, Lisboa, Thiago Costa, Azevedo, Luciano César Pontes de, Veiga, Viviane Cordeiro, Catarino, Daniela Ghidetti Mangas, Fogazzi, Debora Vacaro, Arns, Beatriz, Piastrelli, Filipe Teixeira, Dietrich, Camila, Negrelli, Karina Leal, Jesuíno, Isabella de Andrade, Reis, Luiz Fernando Lima, Mattos, Renata Rodrigues de, Pinheiro, Carla Cristina Gomes, Luz, Mariane Nascimento, Spadoni, Clayse Carla da Silva, Moro, Elisângela Emilene, Bueno, Flávia Regina, Sampaio, Camila Santana Justo Cintra, Silva, Débora Patrício, Baldassare, Franca Pellison, Silva, Ana Cecilia Alcantara, Veiga, Thabata, Barbante, Leticia, Lambauer, Marianne, Campos, Viviane Bezerra, Santos, Elton, Santos, Renato Hideo Nakawaga, Laranjeiras, Ligia Nasi, Valeis, Nanci, Santucci, Eliana, Miranda, Tamiris Abait, Patrocínio, Ana Cristina Lagoeiro do, Carvalho, Andréa de, Sousa, Eduvirgens Maria Couto de, Sousa, Ancelmo Honorato Ferraz de, Malheiro, Daniel Tavares, Bezerra, Isabella Lott, Rodrigues, Mirian Batista, Malicia, Julliana Chicuta, Silva, Sabrina Souza da, Gimenes, Bruna dos Passos, Sesin, Guilhermo Prates, Zavascki, Alexandre Prehn, Sganzerla, Daniel, Medeiros, Gregory Saraiva, Santos, Rosa da Rosa Minho dos, Silva, Fernanda Kelly Romeiro, Cheno, Maysa Yukari, Abrahão, Carolinne Ferreira, Oliveira Junior, Haliton Alves de, Rocha, Leonardo Lima, Nunes Neto, Pedro Aniceto, Pereira, Valéria Chagas, Paciência, Luis Eduardo Miranda, Bueno, Elaine Silva, Caser, Eliana Bernadete, Ribeiro, Larissa Zuqui, Fernandes, Caio Cesar Ferreira, Garcia, Juliana Mazzei, Silva, Vanildes de Fátima Fernandes, Santos, Alisson Junior dos, Machado, Flávia Ribeiro, Souza, Maria Aparecida de, Ferronato, Bianca Ramos, Urbano, Hugo Corrêa de Andrade, Moreira, Danielle Conceição Aparecida, Souza-Dantas, Vicente Cés de, Duarte, Diego Meireles, Coelho, Juliana, Figueiredo, Rodrigo Cruvinel, Foreque, Fernanda, Romano, Thiago Gomes, Cubos, Daniel, Spirale, Vladimir Miguel, Nogueira, Roberta Schiavon, Maia, Israel Silva, Zandonai, Cassio Luis, Lovato, Wilson José, Cerantola, Rodrigo Barbosa, Toledo, Tatiana Gozzi Pancev, Tomba, Pablo Oscar, Almeida, Joyce Ramos de, Sanches, Luciana Coelho, Pierini, Leticia, Cunha, Mariana, Sousa, Michelle Tereza, Azevedo, Bruna, Dal-Pizzol, Felipe, Damasio, Danusa de Castro, Bainy, Marina Peres, Beduhn, Dagoberta Alves Vieira, Jatobá, Joana D’Arc Vila Nova, Moura, Maria Tereza Farias de, Rego, Leila Rezegue de Moraes, Silva, Adria Vanessa da, Oliveira, Luana Pontes, Sodré Filho, Eliene Sá, Santos, Silvana Soares dos, Neves, Itallo de Lima, Leão, Vanessa Cristina de Aquino, Paes, João Lucidio Lobato, Silva, Marielle Cristina Mendes, Oliveira, Cláudio Dornas de, Santiago, Raquel Caldeira Brant, Paranhos, Jorge Luiz da Rocha, Wiermann, Iany Grinezia da Silva, Pedroso, Durval Ferreira Fonseca, Sawada, Priscilla Yoshiko, Prestes, Rejane Martins, Nascimento, Glícia Cardoso, Grion, Cintia Magalhães Carvalho, Carrilho, Claudia Maria Dantas de Maio, Dantas, Roberta Lacerda Almeida de Miranda, Silva, Eliane Pereira, Silva, Antônio Carlos da, Oliveira, Sheila Mara Bezerra de, Golin, Nicole Alberti, Tregnago, Rogerio, Lima, Valéria Paes, Silva, Kamilla Grasielle Nunes da, Boschi, Emerson, Buffon, Viviane, Machado, André Sant’Ana, Capeletti, Leticia, Foernges, Rafael Botelho, Carvalho, Andréia Schubert de, Oliveira Junior, Lúcio Couto de, Oliveira, Daniela Cunha de, Silva, Everton Macêdo, Ribeiro, Julival, Pereira, Francielle Constantino, Salgado, Fernanda Borges, Deutschendorf, Caroline, Silva, Cristofer Farias da, Gobatto, Andre Luiz Nunes, Oliveira, Carolaine Bomfim de, Dracoulakis, Marianna Deway Andrade, Alvaia, Natália Oliveira Santos, Souza, Roberta Machado de, Araújo, Larissa Liz Cardoso de, Melo, Rodrigo Morel Vieira de, Passos, Luiz Carlos Santana, Vidal, Claudia Fernanda de Lacerda, Rodrigues, Fernanda Lopes de Albuquerque, Kurtz, Pedro, Shinotsuka, Cássia Righy, Tavares, Maria Brandão, Santana, Igor das Virgens, Gavinho, Luciana Macedo da Silva, Nascimento, Alaís Brito, Pereira, Adriano J, and Cavalcanti, Alexandre Biasi

Subjects
Intensive care units, Sistemas de gerenciamento de bases de dados, General Medicine, Critical Care and Intensive Care Medicine, Database, Unidades de terapia intensiva, Infecções bacterianas, Bacterial infections, Farmacorresistência bacteriana, bacterial, IMPACTO-MR, Database management systems, Bases de dados, Software, Drug-resistance
Abstract

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials.

Published
2022

23. Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Author

Sekine, Leo, Arns, Beatriz, Fabro, Bruna Rosa, Cipolat, Murillo Machado, Machado, Rafael Rahal Guaragna, Durigon, Edison Luiz, Parolo, Edino, Pellegrini, José Augusto Santos, Viana, Marina Verçoza, Schwarz, Patrícia, Lisboa, Thiago Costa, Dora, José Miguel Silva, Portich, Julia Plentz, Paz, Alessandra Aparecida, Silla, Lucia Mariano da Rocha, Balsan, Almeri Marlene, Schirmer, Felippe da Silva, Franz, Juliana Pires Marafon, Silveira, Luciana M. da, Breunig, Raquel Cristine, Petersen, Viviana, Sosnoski, Monalisa, Mesquita, Nanci Felix, Volpato, Fabiana Caroline Zempulski, Sganzerla, Daniel, Falavigna, Maicon, Rosa, Regis Goulart, Zavascki, Alexandre Prehn, Oliveira, Ana Claudia Tonelli de, Malaquias, Andreia Rocha, Silva, Ane Katiussa Siqueira Fröhlic da, Araujo, Anelise Bergmann, Araújo Antônia Cícera da Silva, Blos, Bruna, Cohen, Carolina Rodrigues, Borges, Cristiane Tavares, Rocha, Cristiano Rossa da, Speransa, Daniela Michelim Rodriguez, Oliveira, Delany da Silva, Rados, Dimitris Rucks Varvaki, Bonacina, Francine, Salton, Gabrielle Dias, Zucchetti, Giovana, Freitas, Isabel Cristina, Constante, Juliana Goncalves, Furlan, Juliana Monteiro, Kleber, Karine, Vieira, Laís Pelentier, Pires, Leonardo Martins, Röhsig, Liane Marise, Vargas, Luciana do Nascimento, Leão, Marize do Socorro Vulcão, Angeli, Melissa Helena, Seltenreich, Patricia Paim Ferreira, Silva, Patricia Santos da, Scheffel, Rafael Selbach, Boehm, Renata Eliane, Mello, Renato Gorga Bandeira de, and Souza, Thabyta Silva Franco de

Subjects
COVID-19
Abstract

Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone.

Published
2022

24. Retorno ao trabalho após a alta da unidade de terapia intensiva: uma coorte multicêntrica brasileira

Author

Mattioni, Mariana F, Dietrich, Camila, Sganzerla, Daniel, Rosa, Régis Goulart, and Teixeira, Cassiano

Subjects
Unidades de terapia intensiva, Intensive care units, Return to work, Prognóstico, Health expenditures, General Medicine, Retorno ao trabalho, Gastos em saúde, Prognosis, Critical Care and Intensive Care Medicine
Abstract

RESUMO Objetivo: Descrever a taxa e os fatores relacionados ao não retorno ao trabalho no terceiro mês pós-alta da unidade de terapia intensiva, além dos impactos do desemprego, da perda de renda e dos gastos com saúde para os sobreviventes. Métodos: Estudo de coorte prospectivo multicêntrico, que incluiu sobreviventes da doença aguda grave, hospitalizados entre 2015 e 2018, previamente empregados, que permaneceram mais de 72 horas internados na unidade de terapia intensiva. Os desfechos foram avaliados por entrevista telefônica no terceiro mês após a alta. Resultados: Dos 316 pacientes incluídos no estudo que trabalhavam previamente, 193 (61,1%) não retornaram ao trabalho nos 3 meses após a alta da unidade de terapia intensiva. Foram associados ao não retorno ao trabalho: baixo nível educacional (razão de prevalência de 1,39; IC95% 1,10 - 1,74; p = 0,006), vínculo empregatício prévio (razão de prevalência de 1,32; IC95% 1,10 - 1,58; p = 0,003), necessidade de ventilação mecânica (razão de prevalência de 1,20; IC95% 1,01 - 1,42; p = 0,04) e dependência física no terceiro mês pós-alta (razão de prevalência de 1,27; IC95% 1,08 - 1,48; p = 0,003). Os sobreviventes incapazes de retornar ao trabalho mais frequentemente apresentaram redução da renda familiar (49,7% versus 33,3%; p = 0,008) e aumento dos gastos em saúde (66,9% versus 48,3%; p = 0,002) quando comparados àqueles que retornaram ao trabalho no terceiro mês após a alta da unidade de terapia intensiva. Conclusão: Frequentemente, os sobreviventes de unidade de terapia intensiva não retornam ao trabalho até o terceiro mês pós-alta da unidade de terapia intensiva. Baixo nível educacional, trabalho formal, necessidade de suporte ventilatório e dependência física no terceiro mês pós-alta relacionaram-se ao não retorno ao trabalho. O não retorno ao trabalho também se relacionou com redução na renda familiar e aumento dos custos com saúde após a alta da unidade de terapia intensiva. ABSTRACT Objective: To describe the rate and factors related to nonreturn to work in the third month after discharge from the intensive care unit and the impact of unemployment, loss of income and health care expenses for survivors. Methods: This was a prospective multicenter cohort study that included survivors of severe acute illness who were hospitalized between 2015 and 2018, previously employed, and who stayed more than 72 hours in the intensive care unit. Outcomes were assessed by telephone interview in the third month after discharge. Results: Of the 316 patients included in the study who had previously worked, 193 (61.1%) did not return to work within 3 months after discharge from the intensive care unit. The following factors were associated with nonreturn to work: low educational level (prevalence ratio 1.39; 95%CI 1.10 - 1.74; p = 0.006), previous employment relationship (prevalence ratio 1.32; 95%CI 1 10 - 1.58; p = 0.003), need for mechanical ventilation (prevalence ratio 1.20; 95%CI 1.01 - 1.42; p = 0.04) and physical dependence in the third month after discharge (prevalence ratio 1.27; 95%CI 1.08 - 1.48; p = 0.003). Survivors who were unable to return to work more often had reduced family income (49.7% versus 33.3%; p = 0.008) and increased health expenditures (66.9% versus 48.3%; p = 0.002). compared to those who returned to work in the third month after discharge from the intensive care unit. Conclusion: Intensive care unit survivors often do not return to work until the third month after discharge from the intensive care unit. Low educational level, formal job, need for ventilatory support and physical dependence in the third month after discharge were related to nonreturn to work. Failure to return to work was also associated with reduced family income and increased health care costs after discharge.

Published
2022

25. IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units

Author

Tomazini, Bruno M., primary, Nassar Júnior, Antonio Paulo, additional, Lisboa, Thiago Costa, additional, Azevedo, Luciano César Pontes de, additional, Veiga, Viviane Cordeiro, additional, Catarino, Daniela Ghidetti Mangas, additional, Fogazzi, Debora Vacaro, additional, Arns, Beatriz, additional, Piastrelli, Filipe Teixeira, additional, Dietrich, Camila, additional, Negrelli, Karina Leal, additional, Jesuíno, Isabella de Andrade, additional, Reis, Luiz Fernando Lima, additional, Mattos, Renata Rodrigues de, additional, Pinheiro, Carla Cristina Gomes, additional, Luz, Mariane Nascimento, additional, Spadoni, Clayse Carla da Silva, additional, Moro, Elisângela Emilene, additional, Bueno, Flávia Regina, additional, Sampaio, Camila Santana Justo Cintra, additional, Silva, Débora Patrício, additional, Baldassare, Franca Pellison, additional, Silva, Ana Cecilia Alcantara, additional, Veiga, Thabata, additional, Barbante, Leticia, additional, Lambauer, Marianne, additional, Campos, Viviane Bezerra, additional, Santos, Elton, additional, Santos, Renato Hideo Nakawaga, additional, Laranjeiras, Ligia Nasi, additional, Valeis, Nanci, additional, Santucci, Eliana, additional, Miranda, Tamiris Abait, additional, Patrocínio, Ana Cristina Lagoeiro do, additional, Carvalho, Andréa de, additional, Sousa, Eduvirgens Maria Couto de, additional, Sousa, Ancelmo Honorato Ferraz de, additional, Malheiro, Daniel Tavares, additional, Bezerra, Isabella Lott, additional, Rodrigues, Mirian Batista, additional, Malicia, Julliana Chicuta, additional, Silva, Sabrina Souza da, additional, Gimenes, Bruna dos Passos, additional, Sesin, Guilhermo Prates, additional, Zavascki, Alexandre Prehn, additional, Sganzerla, Daniel, additional, Medeiros, Gregory Saraiva, additional, Santos, Rosa da Rosa Minho dos, additional, Silva, Fernanda Kelly Romeiro, additional, Cheno, Maysa Yukari, additional, Abrahão, Carolinne Ferreira, additional, Oliveira Junior, Haliton Alves de, additional, Rocha, Leonardo Lima, additional, Nunes Neto, Pedro Aniceto, additional, Pereira, Valéria Chagas, additional, Paciência, Luis Eduardo Miranda, additional, Bueno, Elaine Silva, additional, Caser, Eliana Bernadete, additional, Ribeiro, Larissa Zuqui, additional, Fernandes, Caio Cesar Ferreira, additional, Garcia, Juliana Mazzei, additional, Silva, Vanildes de Fátima Fernandes, additional, Santos, Alisson Junior dos, additional, Machado, Flávia Ribeiro, additional, Souza, Maria Aparecida de, additional, Ferronato, Bianca Ramos, additional, Urbano, Hugo Corrêa de Andrade, additional, Moreira, Danielle Conceição Aparecida, additional, Souza-Dantas, Vicente Cés de, additional, Duarte, Diego Meireles, additional, Coelho, Juliana, additional, Figueiredo, Rodrigo Cruvinel, additional, Foreque, Fernanda, additional, Romano, Thiago Gomes, additional, Cubos, Daniel, additional, Spirale, Vladimir Miguel, additional, Nogueira, Roberta Schiavon, additional, Maia, Israel Silva, additional, Zandonai, Cassio Luis, additional, Lovato, Wilson José, additional, Cerantola, Rodrigo Barbosa, additional, Toledo, Tatiana Gozzi Pancev, additional, Tomba, Pablo Oscar, additional, Almeida, Joyce Ramos de, additional, Sanches, Luciana Coelho, additional, Pierini, Leticia, additional, Cunha, Mariana, additional, Sousa, Michelle Tereza, additional, Azevedo, Bruna, additional, Dal-Pizzol, Felipe, additional, Damasio, Danusa de Castro, additional, Bainy, Marina Peres, additional, Beduhn, Dagoberta Alves Vieira, additional, Jatobá, Joana D’Arc Vila Nova, additional, Moura, Maria Tereza Farias de, additional, Rego, Leila Rezegue de Moraes, additional, Silva, Adria Vanessa da, additional, Oliveira, Luana Pontes, additional, Sodré Filho, Eliene Sá, additional, Santos, Silvana Soares dos, additional, Neves, Itallo de Lima, additional, Leão, Vanessa Cristina de Aquino, additional, Paes, João Lucidio Lobato, additional, Silva, Marielle Cristina Mendes, additional, Oliveira, Cláudio Dornas de, additional, Santiago, Raquel Caldeira Brant, additional, Paranhos, Jorge Luiz da Rocha, additional, Wiermann, Iany Grinezia da Silva, additional, Pedroso, Durval Ferreira Fonseca, additional, Sawada, Priscilla Yoshiko, additional, Prestes, Rejane Martins, additional, Nascimento, Glícia Cardoso, additional, Grion, Cintia Magalhães Carvalho, additional, Carrilho, Claudia Maria Dantas de Maio, additional, Dantas, Roberta Lacerda Almeida de Miranda, additional, Silva, Eliane Pereira, additional, Silva, Antônio Carlos da, additional, Oliveira, Sheila Mara Bezerra de, additional, Golin, Nicole Alberti, additional, Tregnago, Rogerio, additional, Lima, Valéria Paes, additional, Silva, Kamilla Grasielle Nunes da, additional, Boschi, Emerson, additional, Buffon, Viviane, additional, Machado, André Sant’Ana, additional, Capeletti, Leticia, additional, Foernges, Rafael Botelho, additional, Carvalho, Andréia Schubert de, additional, Oliveira Junior, Lúcio Couto de, additional, Oliveira, Daniela Cunha de, additional, Silva, Everton Macêdo, additional, Ribeiro, Julival, additional, Pereira, Francielle Constantino, additional, Salgado, Fernanda Borges, additional, Deutschendorf, Caroline, additional, Silva, Cristofer Farias da, additional, Gobatto, Andre Luiz Nunes, additional, Oliveira, Carolaine Bomfim de, additional, Dracoulakis, Marianna Deway Andrade, additional, Alvaia, Natália Oliveira Santos, additional, Souza, Roberta Machado de, additional, Araújo, Larissa Liz Cardoso de, additional, Melo, Rodrigo Morel Vieira de, additional, Passos, Luiz Carlos Santana, additional, Vidal, Claudia Fernanda de Lacerda, additional, Rodrigues, Fernanda Lopes de Albuquerque, additional, Kurtz, Pedro, additional, Shinotsuka, Cássia Righy, additional, Tavares, Maria Brandão, additional, Santana, Igor das Virgens, additional, Gavinho, Luciana Macedo da Silva, additional, Nascimento, Alaís Brito, additional, Pereira, Adriano J., additional, and Cavalcanti, Alexandre Biasi, additional

Published
2022
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29. Teaming-up nurses with ophthalmologists to expand the reach of eye care in a middle-income country: Validation of health data acquisition by nursing staff in a telemedicine strategy

Author

Garcia Moraes Pagano, Cassia, primary, de Campos Moreira, Tais, additional, Sganzerla, Daniel, additional, Matzenbacher, Ana Maria Frölich, additional, Faria, Amanda Gomes, additional, Matturro, Lucas, additional, Cabral, Felipe Cezar, additional, Rucks Varvaki Rados, Dimitris, additional, Decavata Szortyka, Anelise, additional, Falavigna, Maicon, additional, Vinadé Chagas, Maria Eulalia, additional, Harzheim, Erno, additional, Gonçalves, Marcelo, additional, Umpierre, Roberto, additional, and Lutz de Araujo, Aline, additional

Published
2021
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31. Convalescent plasma for COVID-19 in hospitalised patients: an open-label, randomised clinical trial

Author

Sekine, Leo, primary, Arns, Beatriz, additional, Fabro, Bruna R., additional, Cipolatt, Murillo M., additional, Machado, Rafael R.G., additional, Durigon, Edison L., additional, Parolo, Edino, additional, Pellegrini, José Augusto S., additional, Viana, Marina V., additional, Schwarz, Patrícia, additional, Lisboa, Thiago C., additional, Dora, José Miguel S., additional, Portich, Julia P., additional, Paz, Alessandra A., additional, Silla, Lucia, additional, Balsan, Almeri M., additional, Schirmer, Felipe da-Silva, additional, Franz, Juliana P.M., additional, da-Silveira, Luciana M., additional, Breunig, Raquel C., additional, Petersen, Viviana, additional, Sosnoski, Monalisa, additional, Mesquita, Nanci F., additional, Volpato, Fabiana Caroline Z., additional, Sganzerla, Daniel, additional, Falavigna, Maicon, additional, Rosa, Regis G., additional, and Zavascki, Alexandre P., additional

Published
2021
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32. The Burden of Mental Illness Among Survivors of Critical Care—Risk Factors and Impact on Quality of Life

Author

Teixeira, Cassiano, primary, Rosa, Regis Goulart, additional, Sganzerla, Daniel, additional, Sanchez, Evelin C., additional, Robinson, Caroline Cabral, additional, Dietrich, Camila, additional, Kochhann, Renata, additional, de Souza, Denise, additional, Rech, Gabriela S., additional, da R. dos Santos, Rosa, additional, Schneider, Daniel, additional, Boldo, Rodrigo, additional, Sharshar, Tarek, additional, Bozza, Fernando Augusto, additional, Falavigna, Maicon, additional, and Friedman, Gilberto, additional

Published
2021
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33. SHARPEN SCORE ACCURATELY PREDICTS MORTALITY IN SURGICAL AND NON-SURGICAL PATIENTS WITH INFECTIVE ENDOCARDITIS

Author

Alves, Sofia Giusti, primary, Pivatto, Fernando, additional, Filippini, Filippe Barcellos, additional, Dannenhauer, Gustavo Paglioli, additional, Seroiska, Gabriel, additional, Bischoff, Helena Marcon, additional, Birk, Luiz Felipe Schmidt, additional, Terra, Diego, additional, Sganzerla, Daniel, additional, and Miglioranza, Marcelo, additional

Published
2021
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34. Mechanism of a Flexible ICU Visiting Policy for Anxiety Symptoms Among Family Members in Brazil: A Path Mediation Analysis in a Cluster-Randomized Clinical Trial

Author

Rosa, Regis Goulart, primary, Pellegrini, José Augusto Santos, additional, Moraes, Rafael Barberena, additional, Prieb, Rita Gigliola Gomes, additional, Sganzerla, Daniel, additional, Schneider, Daniel, additional, Robinson, Caroline Cabral, additional, Kochhann, Renata, additional, da Silva, Daiana Barbosa, additional, Amaral, Alexandre, additional, Prestes, Rejane Martins, additional, Medeiros, Gregory Saraiva, additional, Falavigna, Maicon, additional, and Teixeira, Cassiano, additional

Published
2021
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35. Epidemiology and burden of chronic respiratory diseases in Brazil from 1990 to 2017 : analysis for the Global Burden of Disease 2017 Study

Author

Leal, Lisiane Freitas, Cousin Sobrinho, Ewerton Luiz Porto, Bidinotto, Augusto Bacelo, Sganzerla, Daniel, Borges, Rogério Boff, Malta, Deborah Carvalho, Ikuta, Kevin, and Dal Pizzol, Tatiane da Silva

Subjects
Doenças não transmissíveis, Carga global da doença, Respiratory tract diseases, Anos de vida ajustados pela incapacidade, Doenças respiratórias, Doença pulmonar obstrutiva crônica, Noncommunicable diseases, Global burden of Disease, Farmácia, Pulmonary disease, Disability-adjusted life years, Chronic obstructive
Abstract

Introdução: No Brasil, pouco se sabe sobre as tendências das doenças respiratórias crônicas, que foram estimadas como a terceira principal causa de mortes em 2017 em todo o mundo. Métodos: Analisamos as estimativas do Global Burden of Disease (GBD) 2017 para prevalência, incidência, mortalidade, anos de vida ajustados por incapacidade (DALY), uma medida resumida de anos de vida perdidos (YLL) e anos vividos com deficiência (YLD), e fatores de risco atribuíveis a doenças respiratórias crônicas no Brasil, de 1990 a 2017. Resultados: As estimativas gerais diminuíram para todas as idades e ambos os sexos, assim como para as taxas padronizadas por idade. Para a prevalência ajustada pela idade, houve uma redução de 21% e, aproximadamente, 16% para a incidência. Houve uma redução de 42% na mortalidade para ambos os sexos, embora a taxa de mortes para homens tenha sido 30% maior do que a taxa para mulheres. O aumento no número de DALY deveu-se ao crescimento e envelhecimento da população. Observamos um aumento de 34% no número absoluto de DALYs no Brasil durante o período do estudo. A maioria das taxas de DALY foi devido a Doença Pulmonar Obstrutiva Crônica (DPOC). Para todas as idades e ambos os sexos, tabagismo foi o principal fator de risco atribuível. Conclusão: No Brasil, embora a mortalidade, a prevalência e a incidência de doenças respiratórias crônicas tenham diminuído ao longo dos anos, maior atenção deve ser dada ao aumento dos DALYs. O tabagismo permaneceu como principal fator de risco, apesar da redução significativa do seu uso, reforçando a necessidade de manutenção de políticas e programas direcionados à sua cessação. Introduction: In Brazil, little is known about the trends of chronic respiratory diseases, which was estimated as the third leading cause of deaths in 2017 worldwide. Methods: We analyzed Global Burden of Disease (GBD) 2017 estimates for prevalence, incidence, mortality, disability-adjusted life years (DALY), a summary measure of years of life lost (YLLs) and years lived with disability (YLDs), and risk factors attributable to chronic respiratory diseases in Brazil from 1990 to 2017. Results: The overall estimates have decreased for all ages and both sexes, and for age-standardized rates. For age-adjusted prevalence, there was a 21% reduction, and nearly 16% reduction for incidence. There was a 42% reduction in mortality for both sexes, though the rate of deaths for men was 30% greater than the rate in women. The increase in the number of DALY was essentially due to the population growth and population ageing. We observed a 34% increase in the absolute number of DALY in Brazil over the study period. The majority of the DALY rates were due to Chronic Obstructive Pulmonary Disease (COPD). For all ages and both sexes, smoking was the main attributable risk factor. Conclusion: In Brazil, although mortality, prevalence and incidence for chronic respiratory diseases have decreased over the years, attention should be taken to the DALYs increase. Smoking remained as the main risk factor, despite the significant decrease of tobacco use, reinforcing the need for maintenance of policies and programs directed at its cessation.

Published
2020

36. Additional file 1 of Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study

Author

Scolari, Fernando Luís, Schneider, Daniel, Fogazzi, Débora Vacaro, Gus, Miguel, Marciane Maria Rover, Marcely Gimenes Bonatto, Araújo, Gustavo Neves De, Zimerman, André, Sganzerla, Daniel, Goldraich, Lívia Adams, Teixeira, Cassiano, Friedman, Gilberto, Carisi Anne Polanczyk, Rohde, Luis Eduardo, Rosa, Regis Goulart, and Wainstein, Rodrigo Vugman

Abstract

Additional file 1. Supplementary material.

Published
2020
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37. Evidence-Based Checklist for Organ Donor Management – A Cluster-Randomized Trial

Author

Westphal, Glauco Adrieno, primary, Robinson, Caroline Cabral, additional, Giordani, Natalia Elis, additional, Teixeira, Cassiano, additional, Rohden, Adriane Isabel, additional, Gimenes, Bruna dos Passos, additional, Guterres, Cátia Moreira, additional, Madalena, Itiana Cardoso, additional, Andrighetto, Luiza Vitelo, additional, da Silva, Sabrina Souza, additional, da Silva, Daiana Barbosa, additional, Sganzerla, Daniel, additional, Cavalcanti, Alexandre Biasi, additional, Franke, Cristiano Augusto, additional, Bozza, Fernando A., additional, Machado, Flávia Ribeiro, additional, de Andrade, Joel, additional, Azevedo, Luciano Cesar Pontes, additional, Schneider, Silvana, additional, Orlando, Bianca Rodrigues, additional, Grion, Cintia Magalhães Carvalho, additional, Bezerra, Fernando Albuerne, additional, Roman, Fernando Roberto, additional, Leite Júnior, Francisco Olon, additional, Siqueira, Íris de Lima Ferraz, additional, Oliveira, João Fernando Picollo, additional, de Oliveira Júnior, Lúcio Couto, additional, de Melo, Maria de Fátima Rodrigues Bua, additional, Leal, Patrícia Berg Gonçalves Perei, additional, Diniz, Pedro Carvalho, additional, Moraes, Rafael Barberena, additional, Pontes, Daniela Ferreira Salomão, additional, Queiroz, Joselio Emar de Araujo, additional, Hammes, Luciano Serpa, additional, Meade, Maureen, additional, Rosa, Regis Goulart, additional, and Falavigna, Maicon, additional

Published
2021
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38. The 6-Minute Walk Test predicts long-term physical improvement among intensive care unit survivors: a prospective cohort study

Author

Rosa, Regis Goulart, primary, Dietrich, Camila, additional, Valle, Enio Luiz Tschiedel do, additional, Souza, Denise, additional, Tagliari, Luciana, additional, Mattioni, Mariana, additional, Tonietto, Túlio Frederico, additional, Rosa, Rosa da, additional, Barbosa, Mirceli Goulart, additional, Lovatel, Gisele Agustini, additional, Lago, Pedro Dal, additional, Oliveira, Eubrando Silvestre, additional, Sganzerla, Daniel, additional, Andrade, Juliana M. S., additional, Berto, Paula, additional, Cardoso, Paulo Ricardo, additional, Sanchez, Evelin Carneiro, additional, Falavigna, Maicon, additional, Maccari, Juçara G., additional, Rech, Gabriela, additional, Robinson, Caroline, additional, Schneider, Daniel, additional, Leon, Patrícia de, additional, Biason, Lívia, additional, and Teixeira, Cassiano, additional

Published
2021
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39. Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort study

Author

Scolari, Fernando, primary, Schneider, Daniel, additional, Fogazzi, Débora Vacaro, additional, Gus, Miguel, additional, Rover, Marciane Maria, additional, Bonatto, Marcely Gimenes, additional, de Araújo, Gustavo Neves, additional, Zimerman, André, additional, Sganzerla, Daniel, additional, Goldraich, Lívia Adams, additional, Teixeira, Cassiano, additional, Friedman, Gilberto, additional, Polanczyk, Carisi Anne, additional, Rohde, Luis Eduardo, additional, Rosa, Regis Goulart, additional, and Wainstein, Rodrigo Vugman, additional

Published
2020
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40. Brazilian Translation, Cross-Cultural Adaptation, Validity, and Reliability of the EMpowerment of PArents in THe Intensive Care 30 (EMPATHIC-30) Questionnaire to Measure Parental Satisfaction in PICUs

Author

Lessa, Alessandra D., primary, Cabral, Felipe C., additional, Tonial, Cristian T., additional, Costa, Caroline A. D., additional, Andrades, Gabriela R. H., additional, Crestani, Francielly, additional, Einloft, Paulo R., additional, Bruno, Francisco, additional, Sganzerla, Daniel, additional, Matte, Maria C. C., additional, Fiori, Humberto H., additional, Latour, Jos M., additional, and Garcia, Pedro Celiny R., additional

Published
2020
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42. Quality of life after intensive care unit: a multicenter cohort study protocol for assessment of long-term outcomes among intensive care survivors in Brazil

Author

Robinson,Caroline Cabral, Rosa,Regis Goulart, Kochhann,Renata, Schneider,Daniel, Sganzerla,Daniel, Dietrich,Camila, Sanchez,Évelin Carneiro, Dutra,Francine Hoffmann, Oliveira,Maicon Quadro de, Anzolin,Luisa Barbosa, Menezes,Suelen Fardim de, Jeffman,Rodrigo, Souza,Denise de, Silva,Sâmia Faria da, Cruz,Luciane Nascimento, Boldo,Rodrigo, Cardoso,Juliana Rezende, Birriel,Daniella Cunha, Gamboa,Mariana Nunes, Machado,André Sant'Ana, Andrade,Juliana Mara Stormosvski de, Alencar,Cesar, Teixeira,Michelle Carneiro, Vieira,Silvia Regina Rios, Moreira,Fernanda Caleffe, Amaral,Alexandre, Silveira,Ana Paula Menezes, Teles,José Mario Meira, Oliveira,Daniela Cunha de, Oliveira Júnior,Lúcio Couto de, Castro,Lívia Correa e, Silva,Marli Sarmento da, Neves,Rafael Trevizoli, Gomes,Renata de Andrade, Ribeiro,Cinthia Mucci, Cavalcanti,Alexandre Biasi, Oliveira,Roselaine Pinheiro de, Maccari,Juçara Gasparetto, Berto,Paula Pinheiro, Martins,Lucieda Araújo, Santos,Rui Leandro da Silva, Ue,Luciana Yumi, Hammes,Luciano Serpa, Sharshar,Tarek, Bozza,Fernando, Falavigna,Maicon, and Teixeira,Cassiano

Subjects
Quality of life, Disabled persons, Depression, Transtornos de estresse pós-traumáticos, lcsh:Medical emergencies. Critical care. Intensive care. First aid, lcsh:RC86-88.9, Anxiety, Resultados de cuidados críticos, Pessoas com deficiência, Qualidade de vida, Cognitive dysfunction, Critical care outcomes, Depressão, Ansiedade, Stress disorders, Posttraumatic, Disfunção Cognitiva
Abstract

RESUMO Objetivo: Avaliar a prevalência de incapacidades físicas, cognitivas e psiquiátricas, fatores associados e sua relação com qualidade de vida em pacientes sobreviventes de internação em unidades de terapia intensiva brasileiras. Métodos: Um estudo de coorte prospectivo multicêntrico está sendo conduzido em dez unidades de terapia intensiva adulto clínico-cirúrgicas representativas das cinco regiões geopolíticas do Brasil. Pacientes com idade ≥ 18 anos que receberam alta das unidades de terapia intensiva participantes e permaneceram internados na unidade de terapia intensiva por 72 horas ou mais, nos casos de internação clínica ou cirúrgica de urgência, e por 120 horas ou mais, nos casos de internação cirúrgica eletiva, serão incluídos de forma consecutiva. Estes pacientes serão seguidos por 1 ano, por meio de entrevistas telefônicas estruturadas 3, 6 e 12 meses pós-alta da unidade de terapia intensiva. Dependência funcional, disfunção cognitiva, sintomas de ansiedade e depressão, sintomas de estresse pós-traumático, qualidade de vida relacionada à saúde, re-hospitalizações e mortalidade em longo prazo serão avaliados como desfechos. Discussão: O presente estudo tem o potencial de contribuir para o conhecimento a respeito da prevalência e dos fatores associados à síndrome pós-cuidados intensivos na população de pacientes adultos sobreviventes de internação em unidades de terapia intensiva brasileiras. Ademais, a associação entre síndrome pós-cuidados intensivos e qualidade de vida relacionada à saúde poderá ser estabelecida. ABSTRACT Objective: To establish the prevalence of physical, cognitive and psychiatric disabilities, associated factors and their relationship with the qualities of life of intensive care survivors in Brazil. Methods: A prospective multicenter cohort study is currently being conducted at 10 adult medical-surgical intensive care units representative of the 5 Brazilian geopolitical regions. Patients aged ≥ 18 years who are discharged from the participating intensive care units and stay 72 hours or more in the intensive care unit for medical or emergency surgery admissions or 120 hours or more for elective surgery admissions are consecutively included. Patients are followed up for a period of one year by means of structured telephone interviews conducted at 3, 6 and 12 months after discharge from the intensive care unit. The outcomes are functional dependence, cognitive dysfunction, anxiety and depression symptoms, posttraumatic stress symptoms, health-related quality of life, rehospitalization and long-term mortality. Discussion: The present study has the potential to contribute to current knowledge of the prevalence and factors associated with postintensive care syndrome among adult intensive care survivors in Brazil. In addition, an association might be established between postintensive care syndrome and health-related quality of life.

Published
2019

43. Mechanism of a Flexible ICU Visiting Policy for Anxiety Symptoms Among Family Members in Brazil: A Path Mediation Analysis in a Cluster-Randomized Clinical Trial.

Author

Goulart Rosa, Regis, Santos Pellegrini, José Augusto, Barberena Moraes, Rafael, Gomes Prieb, Rita Gigliola, Sganzerla, Daniel, Schneider, Daniel, Cabral Robinson, Caroline, Kochhann, Renata, Barbosa da Silva, Daiana, Amaral, Alexandre, Martins Prestes, Rejane, Saraiva Medeiros, Gregory, Falavigna, Maicon, Teixeira, Cassiano, Rosa, Regis Goulart, Pellegrini, José Augusto Santos, Moraes, Rafael Barberena, Prieb, Rita Gigliola Gomes, Robinson, Caroline Cabral, and da Silva, Daiana Barbosa

Published
2021
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44. The 6-Minute Walk Test predicts long-term physical improvement among intensive care unit survivors: a prospective cohort study.

Author

Goulart Rosa, Regis, Dietrich, Camila, Tschiedel do Valle, Enio Luiz, Souza, Denise, Tagliari, Luciana, Mattioni, Mariana, Tonietto, Túlio Frederico, da Rosa, Rosa, Goulart Barbosa, Mirceli, Lovatel, Gisele Agustini, Dal Lago, Pedro, Silvestre Oliveira, Eubrando, Sganzerla, Daniel, Andrade, Juliana M. S., Berto, Paula, Cardoso, Paulo Ricardo, Carneiro Sanchez, Evelin, Falavigna, Maicon, Maccari, Jugara G., and Rech, Gabriela

Subjects
PHYSIOLOGICAL aspects of walking, INTENSIVE care patients, EXERCISE tests
Abstract

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Published
2021
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45. Brazilian Translation, Cross-Cultural Adaptation, Validity, and Reliability of the EMpowerment of PArents in THe Intensive Care 30 (EMPATHIC-30) Questionnaire to Measure Parental Satisfaction in PICUs.

Author

Lessa, Alessandra D., Cabral, Felipe C., Tonial, Cristian T., Costa, Caroline A. D., Andrades, Gabriela R. H., Crestani, Francielly, Einloft, Paulo R., Bruno, Francisco, Sganzerla, Daniel, Matte, Maria C. C., Fiori, Humberto H., Latour, Jos M., and Garcia, Pedro Celiny R.

Published
2021
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46. Statistical analysis plan for a clusterrandomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)

Author

Sganzerla, Daniel, Pellegrini, José Augusto Santos, and Rosa, Regis Goulart

Subjects
Unidades de terapia intensiva, Visitas a pacientes, Ensaio clínico controlado aleatório, Delírio
Abstract

Background Most adult intensive care units (ICUs) worldwide adopt restrictive family visitation models (RFVMs). However, evidence, mostly from non-randomized studies, suggests that flexible adult ICU visiting hours are safe policies that can result in benefits such as prevention of delirium and increase in satisfaction with care. Accordingly, the ICU Visits Study was designed to compare the effectiveness and safety of a flexible family visitation model (FFVM) vs. an RFVM on delirium prevention among ICU patients, and also to analyze its potential effects on family members and ICU professionals. Methods/design The ICU Visits Study is a cluster-randomized crossover trial which compares an FFVM (12 consecutive ICU visiting hours per day) with an RFVM (

Published
2018

48. DONORS (Donation Network to Optimise Organ Recovery Study): Study protocol to evaluate the implementation of an evidence-based checklist for brain-dead potential organ donor management in intensive care units, a cluster randomised trial

Author

Westphal, Glauco Adrieno, primary, Robinson, Caroline Cabral, additional, Biasi, Alexandre, additional, Machado, Flávia Ribeiro, additional, Rosa, Regis Goulart, additional, Teixeira, Cassiano, additional, de Andrade, Joel, additional, Franke, Cristiano Augusto, additional, Azevedo, Luciano Cesar Pontes, additional, Bozza, Fernando, additional, Guterres, Cátia Moreira, additional, da Silva, Daiana Barbosa, additional, Sganzerla, Daniel, additional, do Prado, Débora Zechmeister, additional, Madalena, Itiana Cardoso, additional, Rohden, Adriane Isabel, additional, da Silva, Sabrina Souza, additional, Giordani, Natalia Elis, additional, Andrighetto, Luiza Vitelo, additional, Benck, Patrícia Spessatto, additional, Roman, Fernando Roberto, additional, de Melo, Maria de Fátima Rodrigues Buarque, additional, Pereira, Thattyane Borba, additional, Grion, Cintia Magalhães Carvalho, additional, Diniz, Pedro Carvalho, additional, Oliveira, João Fernando Picollo, additional, Mecatti, Giovana Colozza, additional, Alves, Flávio André Cardona, additional, Moraes, Rafael Barberena, additional, Nobre, Vandack, additional, Hammes, Luciano Serpa, additional, Meade, Maureen O, additional, Nothen, Rosana Reis, additional, and Falavigna, Maicon, additional

Published
2019
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