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38 results on '"Sforza, Giorgia"'

4. Prenatal mTOR Inhibitors in Tuberous Sclerosis Complex: Current Insights and Future Directions.

Author

Racioppi, Giacomo, Proietti Checchi, Martina, Sforza, Giorgia, Voci, Alessandra, Mazzone, Luigi, Valeriani, Massimiliano, and Moavero, Romina

Abstract

Background: Tuberous sclerosis complex (TSC) can present prenatally, often with cardiac rhabdomyomas, which, if large, may cause complications such as hydrops fetalis and reduced cardiac output. Prenatal treatment of these lesions with mTOR inhibitors, approved for other TSC manifestations, is under investigation. We hypothesize that mTOR inhibitors could help manage or prevent other TSC-related conditions, particularly neurological issues like epilepsy and CNS lesions, potentially improving neurodevelopmental outcomes. However, the safety of prenatal mTOR treatment remains a concern, especially for foetal development, and limited data are available on neurological outcomes. Methods: We conducted a literature review using PubMed, EMBASE, and Cochrane CENTRAL, focusing on studies involving mTOR inhibitors for prenatal TSC management. The search included case reports and series involving pregnant women diagnosed with TSC or early manifestations like cardiac rhabdomyomas. Keywords included "mTOR Inhibitor", "Rapamycin", "tuberous sclerosis complex", "prenatal", and "rhabdomyoma". Results: Three prenatal mouse studies and eight papers reporting on ten pregnant women treated with mTOR inhibitors were identified. Conclusions: The literature confirms that prenatal mTOR inhibitors may reduce cardiac rhabdomyomas. However, further studies are needed to explore their broader potential, particularly in preventing neurological complications, while carefully considering their impact on intrauterine growth and neurodevelopment. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Unsatisfactory Response to Acute Medications Does Not Affect the Medication Overuse Headache Development in Pediatric Chronic Migraine

Author

Frattale, Ilaria, primary, Ferilli, Michela Ada Noris, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Monte, Gabriele, additional, Checchi, Martina Proietti, additional, Tarantino, Samuela, additional, Mazzone, Luigi, additional, Valeriani, Massimiliano, additional, and Papetti, Laura, additional

Published
2024
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11. Visual Disturbances Spectrum in Pediatric Migraine

Author

Frattale, Ilaria, primary, Papetti, Laura, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Monte, Gabriele, additional, Voci, Alessandra, additional, Proietti Checchi, Martina, additional, Mazzone, Luigi, additional, and Valeriani, Massimiliano, additional

Published
2023
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14. Long-Term Effects of COVID-19 Pandemic on Migraine in Adolescents. A Retrospective Analysis of the Population Attending the Headache Center in Different Phases of the Pandemic

Author

Checchi, Martina Proietti, primary, Tarantino, Samuela, additional, Ursitti, Fabiana, additional, Monte, Gabriele, additional, Moavero, Romina, additional, Sforza, Giorgia, additional, Ferilli, Michela Ada Noris, additional, Grimaldi Capitello, Teresa, additional, Vigevano, Federico, additional, Valeriani, Massimiliano, additional, and Papetti, Laura, additional

Published
2023
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15. Safety of SARS-CoV2 vaccination and COVID-19 short-term outcome in pediatric acquired demyelinating disorders of central nervous system: A single center experience

Author

Monte, Gabriele, primary, Papetti, Laura, additional, Ferilli, Michela Ada Noris, additional, Ursitti, Fabiana, additional, Moavero, Romina, additional, Sforza, Giorgia, additional, Panella, Elena, additional, Tarantino, Samuela, additional, Checchi, Martina Proietti, additional, Vigevano, Federico, additional, Palma, Paolo, additional, and Valeriani, Massimiliano, additional

Published
2023
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16. Case report: A pediatric case of Bickerstaff brainstem encephalitis after COVID-19 vaccination and Mycoplasma pneumoniae infection: Looking for the culprit

Author

Monte, Gabriele, Pro, Stefano, Ursitti, Fabiana, Ferilli, Michela Ada Noris, Moavero, Romina, Papetti, Laura, Sforza, Giorgia, Bracaglia, Giorgia, Vigevano, Federico, Palma, Paolo, and Valeriani, Massimiliano

Subjects
COVID-19 Vaccines, COVID-19 vaccination, Vaccination, Immunology, COVID-19, immune-mediated diseases, Bickerstaff brainstem encephalitis, Mycoplasma pneumoniae, anti-GQ1b antibody, Autoimmune Diseases of the Nervous System, Gangliosides, Pneumonia, Mycoplasma, Encephalitis, Humans, Immunology and Allergy, Child, Brain Stem
Abstract

Bickerstaff brainstem encephalitis (BBE) is a rare, immune-mediated disease characterized by the acute onset of external ophthalmoplegia, ataxia, and consciousness disturbance. It has a complex multifactorial etiology, and a preceding infectious illness is seen in the majority of cases. Immune-mediated neurological syndromes following COVID-19 vaccination have been increasingly described. Here we report the case of a child developing BBE 2 weeks after COVID-19 vaccination. Despite nerve conduction studies and CSF analysis showing normal results, BBE was diagnosed on clinical ground and immunotherapy was started early with a complete recovery. Later, diagnosis was confirmed by positive anti-GQ1b IgG in serum. Even if there was a close temporal relationship between disease onset and COVID-19 vaccination, our patient also had evidence of a recent Mycoplasma pneumoniae infection that is associated with BBE. Indeed, the similarity between bacterial glycolipids and human myelin glycolipids, including gangliosides, could lead to an aberrantly immune activation against self-antigens (i.e., molecular mimicry). We considered the recent Mycoplasma pneumoniae infection a more plausible explanation of the disease onset. Our case report suggests that suspect cases of side effects related to COVID-19 vaccines need a careful evaluation in order to rule out well-known associated factors before claiming for a causal relationship.

Published
2022

17. From the New Diagnostic Criteria to COVID-19 Pandemic Passing Through the Placebo Effect. What Have We Learned in the Management of Pediatric Migrane Over the Past 5 Years?

Author

Papetti, Laura, Tarantino, Samuela, Ursitti, Fabiana, Moavero, Romina, Proietti, Martina Checchi, Sforza, Giorgia, Monte, Gabriele, Ferilli, Michela Ada Noris, Balestri, Martina, Vigevano, Federico, and Valeriani, Massimiliano

Subjects
children, treatment, Neurology, diagnosis, migraine, Neurology (clinical), headache, management
Abstract

In 2018, the Food and Drug Administration (FDA) approval of anti-calcitonin gene-related peptide (CGRP) therapies for the treatment of migraine represented a milestone for the management of the disease in adults. On the contrary, the novelties in the field of pediatric migraine are inserted in a different scenario and still concern: (1) diagnostic criteria of the international classification of headache disorders-3 (ICHD-3) that show numerous limits of applicability in the developmental age; (2) the release of the results of the Childhood and Adolescent Migraine Prevention (CHAMP) study that raised doubts about the usefulness of traditional drugs for the treatment of pediatric migraine; (3) the Coronavirus disease 2019 (COVID-19) pandemic has put the spotlight on the importance of managing the psychological factors associated with the disease. In this mini review we discuss the most relevant news in pediatric migraine over the last 5 years.

Published
2022
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18. Interictal Cognitive Performance in Children and Adolescents With Primary Headache: A Narrative Review

Author

Tarantino, Samuela, primary, Proietti Checchi, Martina, additional, Papetti, Laura, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Ferilli, Michela Ada Noris, additional, Moavero, Romina, additional, Monte, Gabriele, additional, Capitello, Teresa Grimaldi, additional, Vigevano, Federico, additional, and Valeriani, Massimiliano, additional

Published
2022
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19. Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination

Author

Papetti, Laura, primary, Amodeo, Maria Elisa, additional, Sabatini, Letizia, additional, Baggieri, Melissa, additional, Capuano, Alessandro, additional, Graziola, Federica, additional, Marchi, Antonella, additional, Bucci, Paola, additional, D’Ugo, Emilio, additional, Kojouri, Maedeh, additional, Gioacchini, Silvia, additional, Marras, Carlo Efisio, additional, Nucci, Carlotta Ginevra, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Ferilli, Michela Ada Noris, additional, Monte, Gabriele, additional, Moavero, Romina, additional, Vigevano, Federico, additional, Valeriani, Massimiliano, additional, and Magurano, Fabio, additional

Published
2022
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21. Pediatric Neuromyelitis Optica Spectrum Disorder: Case Series and Literature Review

Author

Ferilli, Michela Ada Noris, primary, Paparella, Roberto, additional, Morandini, Ilaria, additional, Papetti, Laura, additional, Figà Talamanca, Lorenzo, additional, Ruscitto, Claudia, additional, Ursitti, Fabiana, additional, Moavero, Romina, additional, Sforza, Giorgia, additional, Tarantino, Samuela, additional, Proietti Checchi, Martina, additional, Vigevano, Federico, additional, and Valeriani, Massimiliano, additional

Published
2021
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23. Migraine and Its Equivalents: What Do They Share? A Narrative Review on Common Pathophysiological Patterns

Author

Frattale, Ilaria, primary, Ruscitto, Claudia, additional, Papetti, Laura, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Moavero, Romina, additional, Ferilli, Michela Ada Noris, additional, Tarantino, Samuela, additional, Balestri, Martina, additional, Vigevano, Federico, additional, Mazzone, Luigi, additional, and Valeriani, Massimiliano, additional

Published
2021
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24. Migralepsy: The Two-Faced Janus of Neurology

Author

Sforza, Giorgia, Ruscitto, Claudia, Moavero, Romina, Ursitti, Fabiana, Ferilli, Michela Ada Noris, Tarantino, Samuela, Balestri, Martina, Vigevano, Federico, Valeriani, Massimiliano, and Papetti, Laura

Subjects
aura, migralepsy, seizure, epilepsy, migraine
Abstract

We report three cases of pediatric patients suffering from migraine aura triggered seizures. This entity, also called migralepsy, still does not have a unique definition today. Migraine and epilepsy are both episodic neurological disorders with periods of interictal well-being; this is indicative of similar pathophysiological mechanisms, such as increased neuronal excitation and ion channel dysfunction. The purpose of this paper is to discuss the clinical and instrumental features of migralepsy through the description of three clinical cases in which the symptoms of the usual migraine aura developed into a generalized tonic-clonic or focal seizure.

Published
2021

26. Neuropsychological Sequelae, Quality of Life and Adaptive Behavior in Children and Adolescents with Anti-NMDAR Encephalitis: A Narrative Review

Author

Tarantino, Samuela, primary, Averna, Roberto, additional, Ruscitto, Claudia, additional, Ursitti, Fabiana, additional, Ferilli, Michela Ada Noris, additional, Moavero, Romina, additional, Papetti, Laura, additional, Proietti Checchi, Martina, additional, Sforza, Giorgia, additional, Balestri, Martina, additional, Grimaldi Capitello, Teresa, additional, Vigevano, Federico, additional, Vicari, Stefano, additional, and Valeriani, Massimiliano, additional

Published
2021
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27. Case Report: Migralepsy: The Two-Faced Janus of Neurology

Author

Sforza, Giorgia, primary, Ruscitto, Claudia, additional, Moavero, Romina, additional, Ursitti, Fabiana, additional, Ferilli, Michela Ada Noris, additional, Tarantino, Samuela, additional, Balestri, Martina, additional, Vigevano, Federico, additional, Valeriani, Massimiliano, additional, and Papetti, Laura, additional

Published
2021
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28. Sleep Disorders in Pediatric Migraine: A Questionnaire-Based Study

Author

Voci, Alessandra, primary, Bruni, Oliviero, additional, Ferilli, Michela Ada Noris, additional, Papetti, Laura, additional, Tarantino, Samuela, additional, Ursitti, Fabiana, additional, Sforza, Giorgia, additional, Vigevano, Federico, additional, Mazzone, Luigi, additional, Valeriani, Massimiliano, additional, and Moavero, Romina, additional

Published
2021
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29. Truths and Myths in Pediatric Migraine and Nutrition

Author

Papetti, Laura, primary, Moavero, Romina, additional, Ferilli, Michela A. N., additional, Sforza, Giorgia, additional, Tarantino, Samuela, additional, Ursitti, Fabiana, additional, Ruscitto, Claudia, additional, Vigevano, Federico, additional, and Valeriani, Massimiliano, additional

Published
2021
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31. Anxiety, Depression, and Body Weight in Children and Adolescents With Migraine

Author

Tarantino, Samuela, primary, Papetti, Laura, additional, Di Stefano, Alessandra, additional, Messina, Valeria, additional, Ursitti, Fabiana, additional, Ferilli, Michela Ada Noris, additional, Sforza, Giorgia, additional, Moavero, Romina, additional, Vigevano, Federico, additional, Gentile, Simonetta, additional, and Valeriani, Massimiliano, additional

Published
2020
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37. Pediatric Neuromyelitis Optica Spectrum Disorder: Case Series and Literature Review.

Author

Ferilli, Michela Ada Noris, Paparella, Roberto, Morandini, Ilaria, Papetti, Laura, Figà Talamanca, Lorenzo, Ruscitto, Claudia, Ursitti, Fabiana, Moavero, Romina, Sforza, Giorgia, Tarantino, Samuela, Proietti Checchi, Martina, Vigevano, Federico, and Valeriani, Massimiliano

Subjects
NEUROMYELITIS optica, MYELIN oligodendrocyte glycoprotein, PERIAQUEDUCTAL gray matter, CENTRAL nervous system, SPINAL cord, LITERATURE reviews
Abstract

Neuromyelitis Optica Spectrum Disorder (NMOSD) is a central nervous system (CNS) inflammatory demyelinating disease characterized by recurrent inflammatory events that primarily involve optic nerves and the spinal cord, but also affect other regions of the CNS, including hypothalamus, area postrema and periaqueductal gray matter. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Recently, myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG negative patients. NMOSD is rare among children and adolescents, but early diagnosis is important to start adequate therapy. In this report, we present cases of seven pediatric patients with NMOSD and we review the clinical and neuroimaging characteristics, diagnosis, and treatment of NMOSD in children. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Childhood primary stabbing headache: A double center study.

Author

Monte, Gabriele, Papetti, Laura, Ursitti, Fabiana, Sforza, Giorgia, Tarantino, Samuela, Proietti, Martina Checchi, D’Agnano, Daniela, Sciruicchio, Vittorio, and Valeriani, Massimiliano

Subjects
*PRIMARY headache disorders, *HEADACHE, *MOTION sickness, *INFANTILE colic, *ABDOMINAL pain, *MIGRAINE
Abstract

Background: Primary stabbing headache (PSH) is an idiopathic headache disorder characterized by head pain occurring as a transient and localized single stab or a series of stabs. The present study aimed to examine the characteristics of childhood PSH and whether they fit the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria. We also investigated the association with migraine and episodic syndromes. Methods: In this retrospective study, we included 60 patients seen at two headache clinics (Rome and Bari) between 2016 and 2022. A headache-focused history was obtained. All patients had normal neurological examination. PSH was defined according to ICHD-3 criteria. Results: Twenty-three patients were male (38%) and median (range) age at disease onset was 8 (3–17) years. Stabs recurred with irregular frequency and their duration varied from a few seconds up to 30 minutes. Stabs were located in different head regions. Twenty-five patients (42%) underwent neuroimaging exams. Five children reported a limitation of daily activities and none had a chronic pattern. Forty-seven patients (78%) reported a family history of primary headache, especially migraine, and forty-three had episodic syndromes (i.e. infantile colic, benign paroxysmal vertigo, motion sickness, recurrent abdominal pain, cyclic vomiting). Twenty patients had an associated primary headache: 16 suffered from migraine and four suffered from tension type-headache. According to ICHD-3 criteria, thirty-one patients had a diagnosis of probable PSH as a result of a duration of stabs longer than a few seconds (>3 seconds). Conclusions: Features of childhood PSH can vary widely. As seen in previous studies, several patients reported a stab duration longer than a few seconds and this might suggest that current ICHD-3 criteria may need adjustments to be suitable for children. High frequency of associated migraine and episodic syndromes could suggest a common pathophysiological mechanism between PSH and migraine. We can hypothesize that PSH and migraine attacks may be part of a spectrum of the same disease, although further evidence is needed. Larger studies with long-term follow-up are needed to improve understanding of this condition. [ABSTRACT FROM AUTHOR]

Published
2024
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