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Acute lymphoblastic leukemia is the most common hematological malignancy at pediatric age. Cardiotoxicity holds the first place among the causes of morbidity and mortality in these patients. Anthracyclines are cytostatic drugs frequently associated with cardiotoxicity. Early diagnosis of cardiac impairment during the treatment of pediatric patients is extremely important, both for modulating future chemotherapy and for administering cardioprotective agents. Long term monitoring after chemotherapy helps to identify the risk of late cardiotoxicity among cancer survivors. There are several biomarkers, already in use or still under study, which may represent an operator-independent alternative for echocardiography in the diagnosis of cardiotoxicity. In case of cardiac damage, the clinician has options for treating or limiting the progression, either with the use of already approved agents, such as Dexrazoxane, or by administrating other cardioprotective drugs. International experts are still attempting to establish the best algorithm for early detection of cardiotoxicity, as well as the most efficient treatment plan in case of already existing myocardial damage in these patients. We present a review on treatment-related cardiotoxicity, including mechanisms of development, useful biomarkers and treatment options, after carefully analyzing specialty literature.

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This paper aims to analyze the elements that define the trade relations between the EU and the U.S. The economic power of the two giants is overwhelming. The two large economies import, export, invest and get more foreign investment than any other country or international organization combined. The historical perspective enables the discussion of the stages of the development of the economic relations between the U.S. and the European countries after World War II, from the heyday of the economic power represented by the United States (1945-1965), through the period marking the end of the American domination (1966-1986) leading to the economic balance between the two giants (1986-present). To better understand the economic and political framework, the role of the New Transatlantic Agenda (NTA-1995), which establishes the strategy of transatlantic relations in the post-Cold War, is outlined and debated. [ABSTRACT FROM AUTHOR]

Copyright of Romanian Review of Eurasian Studies / Revista Română de Studii Eurasiatice is the property of Romanian Review of Eurasian Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives. Previous research has shown that Cushing's syndrome has been linked with higher incidence of cognitive impairment. The beneficial effects of exercise on cognitive function have been demonstrated in clinical studies. This study will test the hypothesis that aerobic exercise leads to improved cognitive function in patients with Cushing's syndrome. Material and Method. 16 patients with Cushing's syndrome (10 with iatrogenic syndrome, 2 with adrenal and 4 with pituitary adenoma) and mild or moderate cognitive impairment were recruited for this study. The mental state examination were evaluated by Folstein test-30-point questionnaire test that is used to screen for cognitive impairment. Training consisted of exercise (such as cycling or fast walking) 5days/week for approximately 30 min/day. The efficacy were evaluated at six months of aerobic exercise treatment. Results. The subjects were between 42 and 58 years age and an evolution of the Cushing's syndrome between 2 and 6 years. Patients were screened initially with a questionnaire detailing their medical history, concomitant medications, smoking status, alcohol consumption. Baseline score of the Folstein test were 20±2.1 points. 10 patients present mild (19-24 points) and 6 patients moderate (10-18 points) cognitive impairment. At the end of six months, the mean score of the Folstein test was improved (20,3±2.1 vs 21.4±3.3, p<0.05).Conclusion. In our study the Folstein score can be corrected significantly by aerobic exercise in patients with Cushing's syndrome. [ABSTRACT FROM AUTHOR]

Tudor Arghezi was not not only a great Romanian poet but also a very prodigious pamphleteer. He had a vocation for polemic and wrote on the most controversial issues of his time, entering into polemic with many writers. Among them were the historian Nicolae Iorga and the poet Ion Barbu. He was even imprisoned two times: in 1919 and 1943 because of his critical articles and his disobedient attitude towards the political parties and Romania's position in the 1st World War and the 2nd World War. In October 1943 he published the nationalistic pamphlet ‟Baroane„, in which the German ambassador in Romania, Manfred von Killinger was accused for his taking part in the loot of our country. [ABSTRACT FROM AUTHOR]

Background and aims: The obstetric care of a pregnancy, as it is practiced today, includes non-invasive screening approaches as well as invasive procedures for the definitive prenatal diagnosis of fetal disorders correlations between indications for prenatal cytogenetic diagnosis and results of the chromosomal analysis made upon fetal cells. The aim of our study was to evaluate the correlations between the screening test results and results of chromosomal analysis on fetal cells. Methods: Amniotic fluid samples from 1159 pregnant women were studied with the rapid FISH method and the cytogenetic analysis (karyotype). The results from both methods were compared. Results: The indications to perform prenatal cytogenetic diagnosis for numerical chromosomal abnormalities were: abnormal results of double or triple test, advanced maternal age, fetal abnormality detected through ultrasound examination, and positive family history for chromosomal anomalies. In our study we identified 30 cases with abnormal numeric chromosomes (18 cases of trisomy 21, 4 cases of trisomy 18, 3 cases of trisomy X, 1 case of monosomy, 2 cases of trisomy XYY, 1 case of trisomy XXY and 1 case of triploidy). Conclusions: This report confirms the importance of screening and the cytogenetic diagnosis in the identification of the numerical chromosomal abnormalities. [ABSTRACT FROM AUTHOR]

Background and Aims: The obstetric care of a pregnancy, as it is practiced today, includes non-invasive screening approaches as well as invasive procedures for the definitive prenatal diagnosis of fetal disorders correlations between indications for prenatal cytogenetic diagnosis and results of the chromosomal analysis made upon fetal cells. The aim of our study was to evaluate the correlations between the screening test results and results of chromosomal analysis on fetal cells., Methods: Amniotic fluid samples from 1159 pregnant women were studied with the rapid FISH method and the cytogenetic analysis (karyotype). The results from both methods were compared., Results: The indications to perform prenatal cytogenetic diagnosis for numerical chromosomal abnormalities were: abnormal results of double or triple test, advanced maternal age, fetal abnormality detected through ultrasound examination, and positive family history for chromosomal anomalies. In our study we identified 30 cases with abnormal numeric chromosomes (18 cases of trisomy 21, 4 cases of trisomy 18, 3 cases of trisomy X, 1 case of monosomy, 2 cases of trisomy XYY, 1 case of trisomy XXY and 1 case of triploidy)., Conclusions: This report confirms the importance of screening and the cytogenetic diagnosis in the identification of the numerical chromosomal abnormalities.