Search

Your search keyword '"Sfeir, R."' showing total 340 results
Start Over Author "Sfeir, R."
340 results on '"Sfeir, R."'

12. The Management of Asymptomatic Congenital Pulmonary Airway Malformation: Results of a European Delphi Survey

Author

Kersten, C.M., Hermelijn, S.M., Mullassery, D., Muthialu, N., Cobanoglu, N., Gartner, S., Bagolan, P., Burgos, C. Mesas, Sgrò, A., Heyman, S., Till, H., Suominen, J., Schurink, M., Desender, L., Losty, P., Steyaert, H., Terheggen-Lagro, S., Metzelder, M., Bonnard, A., Sfeir, R., Singh, M., Yardley, I., Rikkers-Mutsaerts, N., Ent, C.K. van der, Qvist, N., Cox, D.W., Peters, R., Bannier, M., Wessel, L., Proesmans, M., Stanton, M., Hannon, E., Zampoli, M., Morini, F., Tiddens, H., Wijnen, R.M.H., Schnater, J.M., Kersten, C.M., Hermelijn, S.M., Mullassery, D., Muthialu, N., Cobanoglu, N., Gartner, S., Bagolan, P., Burgos, C. Mesas, Sgrò, A., Heyman, S., Till, H., Suominen, J., Schurink, M., Desender, L., Losty, P., Steyaert, H., Terheggen-Lagro, S., Metzelder, M., Bonnard, A., Sfeir, R., Singh, M., Yardley, I., Rikkers-Mutsaerts, N., Ent, C.K. van der, Qvist, N., Cox, D.W., Peters, R., Bannier, M., Wessel, L., Proesmans, M., Stanton, M., Hannon, E., Zampoli, M., Morini, F., Tiddens, H., Wijnen, R.M.H., and Schnater, J.M.

Abstract

Item does not contain fulltext, Consensus on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) is lacking, and comparison between studies remains difficult due to a large variety in outcome measures. We aimed to define a core outcome set (COS) for pediatric patients with an asymptomatic CPAM. An online, three-round Delphi survey was conducted in two stakeholder groups of specialized caregivers (surgeons and non-surgeons) in various European centers. Proposed outcome parameters were scored according to level of importance, and the final COS was established through consensus. A total of 55 participants (33 surgeons, 22 non-surgeons) from 28 centers in 13 European countries completed the three rounds and rated 43 outcome parameters. The final COS comprises seven outcome parameters: respiratory insufficiency, surgical complications, mass effect/mediastinal shift (at three time-points) and multifocal disease (at two time-points). The seven outcome parameters included in the final COS reflect the diversity in priorities among this large group of European participants. However, we recommend the incorporation of these outcome parameters in the design of future studies, as they describe measurable and validated outcomes as well as the accepted age at measurement.

Published
2022

14. Nutritional status at age 1 year in patients born with esophageal atresia: A population-based, prospective cohort study

Author

Depoortere, S. (Suzanne), Lapillonne, A. (Alexandre), Sfeir, R. (Rony), Bonnard, A. (Arnaud), Gelas, T. (Thomas), Panait, N. (Nicoleta), Rabattu, P-Y. (Pierre-Yves), Guignot, A. (Audrey), Lamireau, T. (Thierry), Irtan, S. (Sabine), Habonimana, E. (Edouard), Breton, A. (Anne), Fouquet, V. (Virginie), Allal, H. (Hossein), Elbaz, F. (Frédéric), Talon, I. (Isabelle), Ranke, A. (Aline), Abely, M. (Michel), Michel, J-L. (Jean-Luc), Lirussi Borgnon, J. (Joséphine), Buisson, P. (Philippe), Schmitt, F. (Françoise), Lardy, H. (Hubert), Petit, T. (Thierry), Chaussy, Y. (Yann), Borderon, C. (Corinne), Levard, G. (Guillaume), Cremillieux, C. (Clara), Tolg, C. (Cécilia), Breaud, J. (Jean), Jaby, O. (Olivier), Grossos, C. (Céline), De Vries, P. (Philine), Arnould, M. (Myriam), Pelatan, C. (Cécile), Geiss, S. (Stephan), Laplace, C. (Christophe), Kyheng, M. (MaÉva), Nicolas, A. (Audrey), Aumar, M. (Madeleine), gottrand, F. (Fréderic), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Lille, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital universitaire Robert-Debré [Paris], Hospices Civils de Lyon (HCL), CHU Marseille, CHU Grenoble, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Bordeaux [Bordeaux], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Bicêtre, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Rouen, Normandie Université (NU), CHU Strasbourg, ESPRI-Biobase [CHRU Nancy] (Unité fonctionnelle de la plateforme d’aide à la recherche clinique), CHR La réunion, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Amiens-Picardie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Clermont-Ferrand, Centre hospitalier universitaire de Poitiers (CHU Poitiers), CHU Saint-Etienne, CHU de la Martinique [Fort de France], Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Henri Mondor, CHU Limoges, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional d'Orléans (CHRO), Centre Hospitalier Le Mans (CH Le Mans), CH Colmar, CHU Pointe-à-Pitre/Abymes [Guadeloupe], BOURGEAIS, Véronique, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), CHU Henri Mondor [Créteil], Université de Lille, Inserm, Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], and Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Subjects
catch-up, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV]Life Sciences [q-bio], growth, prematurity, stunting, syndromic, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV] Life Sciences [q-bio], undernutrition, small for gestational age, Pediatrics, Perinatology and Child Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

ObjectiveDespite recent progress in caring for patients born with esophageal atresia (EA), undernutrition and stunting remain common. Our study objective was to assess nutritional status in the first year after birth with EA and to identify factors associated with growth failure.Study designWe conducted a population-based study of all infants born in France with EA between 2010 and 2016. Through the national EA register, we collected prenatal to 1 year follow-up data. We used body mass index and length-for-age ratio Z scores to define patients who were undernourished and stunted, respectively. Factors with P < 0.20 in univariate analyses were retained in a logistic regression model.ResultsAmong 1,154 patients born with EA, body mass index and length-for-age ratio Z scores at 1 year were available for about 61%. Among these, 15.2% were undernourished and 19% were stunted at the age of 1 year. There was no significant catch-up between ages 6 months and 1 year. Patients born preterm (41%), small for gestational age (17%), or with associated abnormalities (55%) were at higher risk of undernutrition and stunting at age 1 year (P < 0.05). Neither EA type nor surgical treatment was associated with growth failure.ConclusionUndernutrition and stunting are common during the first year after birth in patients born with EA. These outcomes are significantly influenced by early factors, regardless of EA type or surgical management. Identifying high-risk patient groups with EA (i.e., those born preterm, small for gestational age, and/or with associated abnormalities) may guide early nutritional support strategies.

Published
2022
Full Text
View/download PDF

15. LONG GAP ESOPHAGEAL ATRESIAÂ: A FRENCH NATIONAL COHORT STUDY FROM 2008 TO 2010: O-03 (16:29 to 16:41)

Author

Parmentier, B. P., Piolat, C. P., Capito, C. A.R.M.E, Schneider, A. S., Elbaz, F. E., Sfeir, R. S., Bonnard, A. B., Sauvat, F. S., Pierre-Yves, P. M., Peycelon, M. P., Audry, G. A., Joyeux, L. J., Laufenburger, A. L., Lam Thanh, J. L., Varlet, F. V., Lardy, H. L., Boubnova, J. B., Gatibelza, M. G., Petit, T. P., De Napoli, S. D., Allal, H. A., M Boyo, A. M., Poli Merol, M. P., Ricard, J. R., Kotobi, H. K., and Auber, F. A.

Published
2016

18. Estudio sobre la importancia socioeconómica de las áreas fuera de la jurisdicción nacional (ABNJ) en la región del Pacífico Sudeste

Author

Olivares-Arenas, M., Yannicelli, B., Zapata-Padilla, L., Sfeir, R., Castellanos-Galindo, G., Aburto, J., Boteler, B., and Guerrero, P.

Abstract

Este reporte tiene como objetivo evaluar la con-tribución al bienestar humano de las activida-des socioeconómicas, actuales y potenciales, en las áreas marinas fuera de la jurisdicción nacio-nal (ABNJ por sus siglas en inglés) del Pacífico Sudeste, destacando la dependencia humana de los servicios ecosistémicos que la biodiver-sidad marina en las áreas fuera de la jurisdic-ción nacional (o BBNJ por sus siglas en inglés) provee, así como también de aquellas activi-dades que compiten en uso o bien generan efectos negativos sobre ella como consecuen-cia de su desarrollo. El estudio se focaliza en los aspectos socioeconómicos que dependen de, e interactúan con, la BBNJ en la región FAO 87, correspondiente al área f rente a las áreas juris-diccionales de Chile, Perú, Ecuador y Colombia (países miembros de la Comisión Permanente del Pacífico Sur o CPPS1), y de manera general para el bienestar de la humanidad. Como parte de esta introducción, se presenta a continuación una primera subsección que provee de contexto en relación a la importancia de los ecosistemas marinos y la relación de la BBNJ con el bienestar humano, seguida por una segunda donde se describe la organización de este reporte.

Published
2021

24. Study on the Socio-Economic Importance of Areas Beyond National Jurisdiction (ABNJ) in the Southeast Pacific Region

Author

Olivares-Arenas, M., Yannicelli, B., Zapata-Padilla, L., Sfeir, R., Castellanos-Galindo, G., Aburto, J., Boteler, B., and Guerrero, P.

Abstract

This report aims to assess the contribution to human well-being of current and potential socio-economic activities in marine Areas Beyond National Jurisdiction (ABNJ) in the Southeast Pacific, highlighting human dependence on the ecosystem services that marine Biodiversity in Areas Beyond National Jurisdiction (BBNJ) provides, as well as on those activities that compete with or generate negative effects on it as a consequence of their deployment. The study focuses on the socio-economic aspects that depend on, and interact with, BBNJ in the FAO 87 region, corresponding to the area in front of the jurisdictional areas of Chile, Peru, Ecuador and Colombia (member countries of the Permanent Commission for the South Pacific or CPPS1), and in general for the well-being of mankind.

Published
2021
Full Text
View/download PDF

27. Integrated genomic analyses of ovarian carcinoma

Author

Bell, D., Berchuck, A., Birrer, M., Chien, J., Cramer, D. W., Dao, F., Dhir, R., DiSaia, P., Gabra, H., Glenn, P., Godwin, A. K., Gross, J., Hartmann, L., Huang, M., Huntsman, D. G., Iacocca, M., Imielinski, M., Kalloger, S., Karlan, B. Y., Morrison, C., Mutch, D., Olvera, N., Orsulic, S., Park, K., Petrelli, N., Rabeno, B., Rader, J. S., Sikic, B. I., Smith-McCune, K., Sood, A. K., Bowtell, D., Testa, J. R., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Gunaratne, P., Hawes, A. C., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Santibanez, J., Reid, J. G., Trevino, L. R., Wu, Y.-Q., Wang, M., Muzny, D. M., Wheeler, D. A., Gibbs, R. A., Sivachenko, A. Y., Sougnez, C., Wilkinson, J., Bloom, T., Fennell, T., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., Koboldt, D. C., McLellan, M. D., Wylie, T., Walker, J., O’Laughlin, M., Dooling, D. J., Fulton, L., Abbott, R., Dees, N. D., Zhang, Q., Kandoth, C., Wendl, M., Schierding, W., Shen, D., Harris, C. C., Schmidt, H., Kalicki, J., Delehaunty, K. D., Fronick, C. C., Demeter, R., Cook, L., Wallis, J. W., Lin, L., Magrini, V. J., Hodges, J. S., Eldred, J. M., Smith, S. M., Pohl, C. S., Vandin, F., Raphael, B. J., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Meyerson, M., Winckler, W., Verhaak, R. G. W., Carter, S. L., Mermel, C. H., Nguyen, H., Onofrio, R. C., Hubbard, D., Gupta, S., Crenshaw, A., Ramos, A. H., Protopopov, A., Zhang, Juinhua, Kim, T. M., Perna, I., Xiao, Y., Ren, G., Sathiamoorthy, N., Lee, E., Park, P. J., Kucherlapati, R., Absher, D. M., Waite, L., Sherlock, G., Brooks, J. D., Li, J. Z., Xu, J., Myers, R. M., Laird, P. W., Cope, L., Herman, J. G., Shen, H., Weisenberger, D. J., Noushmehr, H., Pan, F., Triche, T., Jr, Berman, B. P., Van Den Berg, D. J., Buckley, J., Baylin, S. B., Jakkula, L. R., Dorton, S., Marr, H., Choi, Y. G., Wang, V., Wang, N. J., Ngai, J., Conboy, J. G., Feiler, H. S., Socci, N. D., Liang, Y., Lash, A. E., Brennan, C., Viale, A., Meng, S., Shi, Y., Li, L., Turman, Y. J., Zang, D., Helms, E. B., Zhou, X., Wu, J., Topal, M. D., Zhang, Junihua, Wu, C. J., Shukla, S., Sivachenko, A., Jing, R., Liu, Y., Noble, M., Carter, H., Kim, D., Karchin, R., Korkola, J. E., Heiser, L. M., Cho, R. J., Hu, Z., Parvin, B., Cerami, E., Olshen, A., Reva, B., Antipin, Y., Shen, R., Mankoo, P., Sheridan, R., Ciriello, G., Chang, W. K., Bernanke, J. A., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Sanborn, J. Z., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Wilkerson, M. D., Zhang, N., Akbani, R., Baggerly, K. A., Yung, W. K., Weinstein, J. N., Shelton, T., Grimm, D., Hatfield, M., Morris, S., Yena, P., Rhodes, P., Sherman, M., Paulauskis, J., Millis, S., Kahn, A., Greene, J. M., Sfeir, R., Jensen, M. A., Chen, J., Whitmore, J., Alonso, S., Jordan, J., Chu, A., Zhang, Jinghui, Barker, A., Compton, C., Eley, G., Ferguson, M., Fielding, P., Gerhard, D. S., Myles, R., Schaefer, C., Mills Shaw, K. R., Vaught, J., Vockley, J. B., Good, P. J., Guyer, M. S., Ozenberger, B., Peterson, J., and Thomson, E.

Published
2011
Full Text
View/download PDF

33. DOZ047.30: First year risk factors of mortality and morbidity in esophageal atresia with tracheo-esophageal fistula: data from a population-based national register

Author

Sfeir, R, primary, Rousseau, V, additional, Bonnard, A, additional, Gelas, T, additional, Michaud, L, additional, Boubnova, J, additional, Piolat, C, additional, Irtan, S, additional, Fouquet, V, additional, Mandat, A Le, additional, De Napoli, S, additional, Habonimana, E, additional, Lamireau, T, additional, Lemelle, J L, additional, Elbaz, F, additional, Schneider, A, additional, Polimerol, M L, additional, Allal, H, additional, Buisson, P, additional, Petit, T, additional, Sapin, E, additional, Lardy, H, additional, Podevin, G, additional, Levard, G, additional, Varlet, F, additional, Michel, J L, additional, Jaby, O, additional, Pelatan, C, additional, De Vries, P, additional, Borderon, C, additional, Fourcade, L, additional, Breaud, J, additional, Pouzac, M, additional, Tolg, C, additional, Auber, F, additional, Geiss, S, additional, Laplace, C, additional, Drumez, E, additional, and Gottrand, F, additional

Published
2019
Full Text
View/download PDF

34. DOZ047.55: Midterm follow-up of long-gap esophageal atresia national cohort: study of feeding difficulties and morbidity

Author

Thomas, J, primary, Gottrand, F, additional, Levard, G, additional, Lamireau, T, additional, Michaud, L, additional, Sfeir, R, additional, Michel, J-L, additional, Carcauzon, V, additional, Pouzac, M, additional, Branchereau, S, additional, Petit, T, additional, Sapin, E, additional, Piolat, C, additional, Allal, H, additional, Lemelle, J-L, additional, De Napoli Cocci, S, additional, Ricard, J, additional, Merol, M L P, additional, Elbaz, F, additional, Lardy, H, additional, Schneider, A, additional, Mure, P-Y, additional, Audry, G, additional, Auber, F, additional, Rousseau, V, additional, Bonnard, A, additional, Varlet, F, additional, and Parmentier, B, additional

Published
2019
Full Text
View/download PDF

37. DOZ047.39: Respiratory morbidity at the age of one year in children with esophageal atresia: data from the French National Esophageal Atresia Register

Author

Lejeune, S, primary, Rousseau, V, additional, Bonnard, A, additional, Michaud, L, additional, Gelas, T, additional, Boubnova, J, additional, Jacquier, C, additional, Irtan, S, additional, Breton, A, additional, Fouquet, V, additional, Guinot, A, additional, Lamireau, T, additional, Habonimana, E, additional, Schneider, A, additional, Elbaz, F, additional, Ranke, A, additional, Poli-Merol, M L, additional, Allal, H, additional, Petit, T, additional, Michel, J-L, additional, Buisson, P, additional, Sapin, Z, additional, Lardy, H, additional, Levard, G, additional, Lopez, M, additional, Schmitt, F, additional, Borderon, C, additional, Jaby, O, additional, Pelatan, C, additional, De Vries, P, additional, Pouzac-Arnould, M, additional, Grosos, C, additional, Breaud, J, additional, Tolg, C, additional, Auber, F, additional, Geiss, S, additional, Laplace, C, additional, Sfeir, R, additional, Gottrand, F, additional, Drumez, E, additional, Mourad, S El, additional, and Thumerelle, C, additional

Published
2019
Full Text
View/download PDF

38. DOZ047.01: Risk factors for anastomotic strictures in the first year after esophageal atresia repair: data from a prospective multicentric cohort

Author

Aumar, M, primary, Rousseau, V, additional, Bonnard, A, additional, Sfeir, R, additional, Gelas, T, additional, Boubnova, J, additional, Jacquier, C, additional, Irtan, S, additional, Breton, A, additional, Guinot, A, additional, Lamireau, T, additional, Fouquet, V, additional, Habonimana, E, additional, Schneider, A, additional, Elbaz, F, additional, Ranke, A, additional, Polimerol, M L, additional, Allal, H, additional, Michel, J L, additional, Buisson, P, additional, Petit, T, additional, Sapin, E, additional, Lopez, M, additional, Levard, G, additional, Schmitt, F, additional, Lardy, H, additional, Borderon, C, additional, Jaby, O, additional, Breaud, J, additional, Pelatan, C, additional, Auber, F, additional, Tolg, C, additional, De Vries, P, additional, Pouzac, M, additional, Grosos, C, additional, Geiss, S, additional, Laplace, C, additional, Pierache, A, additional, Gottrand, F, additional, and Michaud, L, additional

Published
2019
Full Text
View/download PDF

41. Position Paper of iNoeA Working Group on Long-Gap esophageal Atresia: For Better care

Author

van der Zee, DC, Bagolan, P, Faure, C, Gottrand, F, Jennings, R, Laberge, J-M, Martinez Ferro, MH, Parmentier, B, Sfeir, R, Teague, W, van der Zee, DC, Bagolan, P, Faure, C, Gottrand, F, Jennings, R, Laberge, J-M, Martinez Ferro, MH, Parmentier, B, Sfeir, R, and Teague, W

Abstract

INoEA is the International Network of Esophageal Atresia and consists of a broad spectrum of pediatric specialties and patient societies. The working group on long-gap esophageal atresia (LGEA) set out to develop guidelines regarding the definition of LGEA, the best diagnostic and treatment strategies, and highlight the necessity of experience and communication in the management of these challenging patients. Review of the literature and expert discussion concluded that LGEA should be defined as any esophageal atresia (EA) that has no intra-abdominal air, realizing that this defines EA with no distal tracheoesophageal fistula (TEF). LGEA is considerably more complex than EA with distal TEFs and should be referred to a center of expertise. The first choice is to preserve the native esophagus and pursue primary repair, delayed primary anastomosis, or traction/growth techniques to achieve anastomosis. A cervical esophagostomy should be avoided if possible. Only if primary anastomosis is not possible, replacement techniques should be used. Jejunal interposition is proposed as the best option among the major EA centers. In light of the infrequent occurrence of LGEA and the technically demanding techniques involved to achieve esophageal continuity, it is strongly advised to develop regional or national centers of expertise for the management and follow-up of these very complex patients.

Published
2017

42. Suivi à un an de l’atrésie de l’oesophage Résultats du registre national français

Author

Schneider, A., Blanc, S., Bonnard, A., Khen-Dunlop, N., Auber, F., Breton, A., Podevin, G., Sfeir, R., Fouquet, V., Jacquier, C., Lemelle, J.-L., Lavrand, F., Becmeur, F., Petit, T., Poli-Merol, M.-L., Elbaz, F., Merrot, T., Michel, J.-L., Allal, H., Lopez, M., Habonimana, E., Pelatan, C., De Lagausie, P., Buisson, P., De Vries, P., Gaudin, J., Lardy, H., Borderon, C., Borgnon, J., Jaby, O., Weil, D., Aubert, D., Geiss, S., Breaud, J., Echaieb, A., Languepin, J., Laplace, C., Pouzac, M., Lefebvre, F., Gottrand, F., and Michaud, L.

Published
2014
Full Text
View/download PDF

46. Review shows that implementing a nationwide protocol for congenital diaphragmatic hernia was a key factor in reducing mortality and morbidity.

Author

Storme, L., Boubnova, J., Mur, S., Pognon, L., Sharma, D., Aubry, E., Sfeir, R., Vaast, P., Rakza, T., Benachi, A., the French Reference Center for Rare Disease «Congenital Diaphragmatic Hernia», and French Reference Center for Rare Disease «Congenital Diaphragmatic Hernia»

Subjects
DIAPHRAGMATIC hernia, NEONATAL mortality, PULMONARY hypertension, PULMONARY hypoplasia, PROGNOSIS
Abstract

The French Rare Disease Reference Center for congenital diaphragmatic hernia (CDH) was created in 2008, to implement a national protocol for foetuses and children with this serious condition. Neonatal mortality from CDH is 30-40%, mainly due to pulmonary hypoplasia and persistent pulmonary hypertension, and half of those who live have high respiratory, nutritional and digestive morbidity. CDH management requires long-term and specialised multidisciplinary care. It has been well established that a standardised management protocol improves the prognosis of children with CDH.Conclusion: Organising health care and implementing a nationwide French protocol were key factors for reducing mortality and morbidity from CDH. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

47. Management and outcome of neonates with a prenatal diagnosis of esophageal atresia type A: A population-based study.

Author

Garabedian, C., Bonnard, A., Rousseau, V., Sfeir, R., CRACMO, Drumez, E., Michaud, L., Gottrand, F., Houfflin‐Debarge, V., and Houfflin-Debarge, V

Abstract

Objective: Evaluate the neonatal management and outcomes of neonates with prenatal diagnosis of esophageal atresia (EA) type A.Methods: This population-based study was conducted using data from the French National Register for infants with EA born from 2008 to 2014, including all cases of EA type A. We compared prenatal and neonatal characteristics and outcomes in children with prenatal diagnosis of EA type A with those with a postnatal diagnosis until the age of 1.Results: A total of 1118 live births with EA were recorded among which 88 (7.9%) were EA type A. Prenatal diagnoses were performed in 75 cases (85.2%), and counselling with a prenatal specialist was conducted in 84.8% of the prenatal group. Still within that group, the gestational age at delivery was significantly higher than in the postnatal group (36 [35-38] versus 34 [32-36] weeks; P = .048). Inborn births were more frequent in the prenatal group (86.1% vs 7.7%, P < .0001), and mortality and outcome were similar in both groups.Conclusion: Prenatal diagnosis is high in EA type A, which enables to offer an antenatal parental counseling and which avoids postnatal transfers. Prognosis of EA types A does not appear to be influenced by the prenatal diagnosis. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

48. Will the Body Temperature be Affected by Lowering Intrathecal Morphine Dose from 100 to 50 Micrograms?

Author

Ishak M, Sfeir R, Ighnatios N, M. Khattar, S. Chamandy, Kamel K, S. Tarraf, and A. Ghosn

Subjects
business.industry, medicine.medical_treatment, Microgram, Spinal anesthesia, Pain scale, Hypothermia, Intrathecal morphine, Anesthesiology and Pain Medicine, Anesthesia, Statistical significance, medicine, Morphine, Caesarean section, medicine.symptom, business, medicine.drug
Abstract

Hypothermia has been reported in parturient undergoing caesarean section during spinal anesthesia. Hypothermia has been reported when a large dose of morphine was used in spinal anesthesia as well as in smaller doses of morphine; however it is not studied yet whether a very small dose of morphine (50 μg) would affect the body temperature without changing the analgesia effect. Our study was performed to determine if the body temperature will be affected significantly by lowering the intrathecal dose of morphine from 100 to 50 micrograms. We performed a prospective randomized double blinded study on parturients scheduled for elective caesarean sections under spinal anesthesia. Body temperatures data was processed using t-test with p-value >0.05. There was no statistical significance in the average body temperatures between patients getting intrathecally 50 versus 100 μg of morphine. Our study demonstrated that the body temperature is not affected by decreasing the intrathecal dose of morphine with no change in parturient’s pain scale.

Published
2013
Full Text
View/download PDF

49. Le diagnostic anténatal modifie-t-il la prise en charge néonatale et le devenir à 1 an des enfants suivis pour atrésie de l’œsophage de type III ?

Author

Garabedian, C., primary, Sfeir, R., additional, Langlois, C., additional, Bonnard, A., additional, Khen-Dunlop, N., additional, Gelas, T., additional, Michaud, L., additional, Auber, F., additional, Piolat, C., additional, Lemelle, J.-L., additional, Fouquet, V., additional, Habonima, É., additional, Becmeur, F., additional, Polimerol, M.-L., additional, Breton, A., additional, Petit, T., additional, Podevin, G., additional, Lavrand, F., additional, Allal, H., additional, Lopez, M., additional, Elbaz, F., additional, Merrot, T., additional, Michel, J.-L., additional, Buisson, P., additional, Sapin, E., additional, Delagausie, P., additional, Pelatan, C., additional, Gaudin, J., additional, Weil, D., additional, de Vries, P., additional, Jaby, O., additional, Lardy, H., additional, Aubert, D., additional, Borderon, C., additional, Fourcade, L., additional, Geiss, S., additional, Breaud, J., additional, Pouzac, M., additional, Echaieb, A., additional, Laplace, C., additional, Gottrand, F., additional, and Houfflin-Debarge, V., additional

Published
2015
Full Text
View/download PDF

50. Integrated genomic analyses of ovarian carcinoma

Author

Bell, D, Berchuck, A, Birrer, M, Chien, J, Cramer, DW, Dao, F, Dhir, R, DiSaia, P, Gabra, H, Glenn, P, Godwin, AK, Triche, T, Berman, BP, Van den Berg, DJ, Buckley, J, Baylin, SB, Zhang, J, Spellman, PT, Purdom, E, Iacocca, M, Shelton, T, Voet, D, Neuvial, P, Bengtsson, H, Jakkula, LR, Durinck, S, Han, J, Dorton, S, Marr, H, Zhang, H, Choi, YG, Wang, V, Wilkinson, J, Nguyen, H, Wang, NJ, Imielinski, M, Ngai, J, Conboy, JG, Parvin, B, Feiler, HS, Speed, TP, Gray, JW, Wu, CJ, Bloom, T, Levine, DA, Li, L, Socci, ND, Liang, Y, Taylor, BS, Kalloger, S, Schultz, N, Borsu, L, Lash, AE, Brennan, C, Ardlie, K, Viale, A, Shukla, S, Grimm, D, Sander, C, Ladanyi, M, Hoadley, KA, Meng, S, Du, Y, Karlan, BY, Shi, Y, Fennell, T, Cibulskis, K, Lawrence, MS, Meyerson, M, Hatfield, M, Mills, GB, Sivachenko, A, Jing, R, Park, RW, Liu, Y, Park, PJ, Ramos, AH, Noble, M, Chin, L, Carter, H, Kim, D, Morris, S, Winckler, W, Karchin, R, Morrison, C, Baldwin, J, Korkola, JE, Yena, P, Heiser, LM, Getz, G, Cho, RJ, Hu, Z, Gabriel, S, Mutch, D, Cerami, E, Rhodes, P, Olshen, A, Verhaak, RGW, Lander, ES, Reva, B, Antipin, Y, Shen, R, Olvera, N, Mankoo, P, Sheridan, R, Ciriello, G, Sherman, M, Chang, WK, Bernanke, JA, Hayes, DN, Carter, SL, Haussler, D, Orsulic, S, Benz, CC, Paulauskis, J, Stuart, JM, Zhang, N, Benz, SC, Sanborn, JZ, Vaske, CJ, Mermel, CH, Zhu, J, Szeto, C, Scott, GK, Yau, C, Rabeno, B, Ding, L, Park, K, Balu, S, Perou, CM, Saksena, G, Wilkerson, MD, Millis, S, Kahn, A, Turman, YJ, Fulton, RS, Onofrio, RC, Greene, JM, Sfeir, R, Jensen, MA, Chen, J, Whitmore, J, Alonso, S, Jordan, J, Chu, A, Rader, JS, Koboldt, DC, Zang, D, Gross, J, Barker, A, Compton, C, Eley, G, Ferguson, M, Fielding, P, Gerhard, DS, Myles, R, McLellan, MD, Schaefer, C, Helms, EB, Shaw, KRM, Sikic, BI, Vaught, J, Vockley, JB, Good, PJ, Guyer, MS, Ozenberger, B, Wylie, T, Peterson, J, Thomson, E, Smith-McCune, K, Sood, AK, Bowtell, D, Hubbard, D, Penny, R, Testa, JR, Chang, K, Walker, J, Dinh, HH, Drummond, JA, Fowler, G, Zhou, X, Gunaratne, P, Hawes, AC, Kovar, CL, Lewis, LR, Gupta, S, Morgan, MB, O'Laughlin, M, Newsham, IF, Santibanez, J, Reid, JG, Trevino, LR, Wu, J, Wu, Y-Q, Wang, M, Muzny, DM, Wheeler, DA, Gibbs, RA, Crenshaw, A, Sivachenko, AY, Topal, MD, Sougnez, C, Dooling, DJ, Fulton, L, Akbani, R, Abbott, R, Dees, ND, Zhang, Q, Kandoth, C, Wendl, M, Schierding, W, Shen, D, Harris, CC, Baggerly, KA, Schmidt, H, Wilson, RK, Kalicki, J, Delehaunty, KD, Fronick, CC, Demeter, R, Cook, L, Wallis, JW, Lin, L, Magrini, VJ, Yung, WK, Hodges, JS, Protopopov, A, Eldred, JM, Smith, SM, Pohl, CS, Vandin, F, Raphael, BJ, Weinstock, GM, Mardis, R, Kim, TM, Hartmann, L, Perna, I, Xiao, Y, Ren, G, Sathiamoorthy, N, Petrelli, N, Lee, E, Kucherlapati, R, Absher, DM, Huang, M, Waite, L, Sherlock, G, Brooks, JD, Li, JZ, Weinstein, JN, Xu, J, Myers, RM, Laird, PW, Cope, L, Herman, JG, Shen, H, Huntsman, DG, Weisenberger, DJ, Noushmehr, H, Pan, F, Massachusetts Institute of Technology. Department of Biology, Lander, Eric S., and Meyerson, Matthew L.

Subjects
endocrine system diseases, Serous carcinoma, Messenger, Gene Dosage, Cancer Genome Atlas Research Network, GYNECOLOGIC-ONCOLOGY-GROUP, GRADE SEROUS CARCINOMA, 0302 clinical medicine, Ovarian carcinoma, Aged, Carcinoma, DNA Methylation, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs, Middle Aged, Mutation, Ovarian Neoplasms, RNA, Messenger, Genomics, Multidisciplinary, Genetics, HYBRID SELECTION, 0303 health sciences, female genital diseases and pregnancy complications, 3. Good health, Multidisciplinary Sciences, Serous fluid, BRCA MUTATION CARRIERS, 030220 oncology & carcinogenesis, DNA methylation, PARP inhibitor, Science & Technology - Other Topics, General Science & Technology, Biology, Article, 03 medical and health sciences, CLEAR-CELL CARCINOMA, MD Multidisciplinary, microRNA, HIGH-THROUGHPUT ANNOTATION, medicine, DRIVER MUTATIONS, Gene, 030304 developmental biology, Neoplastic, Science & Technology, MUTANT-CELLS, SOMATIC MUTATIONS, medicine.disease, CANCER STATISTICS, Gene Expression Regulation, Cancer research, RNA, Ovarian cancer
Abstract

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. Pathway analyses suggested that homologous recombination is defective in about half of the tumours analysed, and that NOTCH and FOXM1 signalling are involved in serous ovarian cancer pathophysiology., National Institutes of Health (U.S.) (Grant U54HG003067), National Institutes of Health (U.S.) (Grant U54HG003273), National Institutes of Health (U.S.) (Grant U54HG003079), National Institutes of Health (U.S.) (Grant U24CA126543), National Institutes of Health (U.S.) (Grant U24CA126544), National Institutes of Health (U.S.) (Grant U24CA126546), National Institutes of Health (U.S.) (Grant U24CA126551), National Institutes of Health (U.S.) (Grant U24CA126554), National Institutes of Health (U.S.) (Grant U24CA126561), National Institutes of Health (U.S.) (Grant U24CA126563), National Institutes of Health (U.S.) (Grant U24CA143882), National Institutes of Health (U.S.) (Grant U24CA143731), National Institutes of Health (U.S.) (Grant U24CA143835), National Institutes of Health (U.S.) (Grant U24CA143845), National Institutes of Health (U.S.) (Grant U24CA143858), National Institutes of Health (U.S.) (Grant U24CA144025), National Institutes of Health (U.S.) (Grant U24CA143866), National Institutes of Health (U.S.) (Grant U24CA143867), National Institutes of Health (U.S.) (Grant U24CA143848), National Institutes of Health (U.S.) (Grant U24CA143843), National Institutes of Health (U.S.) (Grant R21CA135877)

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results