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134 results on '"Sfeir, Jad"'

1. Bone health in autosomal dominant polycystic kidney disease (ADPKD) patients after kidney transplantation

Author

Zubidat, Dalia, Hanna, Christian, Randhawa, Amarjyot K., Smith, Byron H., Chedid, Maroun, Kaidbay, Daniel-Hasan N., Nardelli, Luca, Mkhaimer, Yaman G., Neal, Reem M., Madsen, Charles D., Senum, Sarah R., Gregory, Adriana V., Kline, Timothy L., Zoghby, Ziad M., Broski, Stephen M., Issa, Naim S., Harris, Peter C., Torres, Vicente E., Sfeir, Jad G., and Chebib, Fouad T.

Published
2023
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2. Hypothyroidism

Author

Sfeir, Jad G., Gharib, Hossein, Bandeira, Francisco, editor, Gharib, Hossein, editor, Griz, Luiz, editor, and Faria, Manuel, editor

Published
2022
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5. Natural history and complications of normocalcemic hyperparathyroidism: a retrospective cohort study.

Author

Hoong, Caroline Wei Shan, Broski, Stephen M, Sfeir, Jad G, and Clarke, Bart Lyman

Subjects
NATURAL history, URINARY calculi, PARATHYROIDECTOMY, HYPERPARATHYROIDISM, PREDICTION models
Abstract

Normocalcemic hyperparathyroidism (NHPT) is variably defined, and information regarding complications and natural history are scarce. We aimed to describe the phenotype of NHPT in relation to hypercalcemic hyperparathyroidism (PHPT) and controls, to determine risk of progression, and to develop a predictive model for progression to PHPT. This is a retrospective chart review of 232 patients at a tertiary medical center, comparing 75 controls, 73 patients with NHPT, and 84 with PHPT. NHPT was intermediate in biochemical profile between controls and PHPT with respect to cCa, iPTH, intraindividual coefficient of variant of cCa, phosphorus, and 25(OH)D. NHPT patients had an increased adjusted risk of urolithiasis (OR 5.34, 95%CI, 2.41-12.71, P  < .001) and fragility fractures (OR 4.53, 95%CI, 1.63-14.84, P  = .006) versus controls, after adjustment for age, sex, and BMI. Fewer NHPT compared with PHPTH patients achieved cure with parathyroidectomy (P  = .001). NHPT more often had nonlocalizing imaging or polyglandular disease (P  = .005). Parathyroidectomy improved biochemical but not BMD parameters in NHPT. Over a median follow-up of 4.23 (IQR 1.76-5.31) years, NHPT patients managed expectantly experienced no change in iPTH, and progression to PHPT occurred in 9%. An XGBoost model combining 6 factors for progression (mean index 2 iPTH, mean index 2 cCa, 24-h urinary calcium, age, 25(OH)D, and presence of urolithiasis) had an area under the curve 1.00 (95%CI, 1.00-1.00, P  < .001) for predicting combined progression. NHPT is a mild variant of PHPT at intermediate risk of urolithiasis and fragility fractures. Cure was less often achieved with parathyroidectomy, which did not improve BMD parameters. Progression was infrequent with conservative management. Because only a minority progressed to PHPT, in addition to lower surgical success rates, we suggest conservative management for the majority of NHPT unless risk factors for progression are identified. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Author

Farr, Joshua N., Atkinson, Elizabeth J., Achenbach, Sara J., Volkman, Tammie L., Tweed, Amanda J., Vos, Stephanie J., Ruan, Ming, Sfeir, Jad, Drake, Matthew T., Saul, Dominik, Doolittle, Madison L., Bancos, Irina, Yu, Kai, Tchkonia, Tamara, LeBrasseur, Nathan K., Kirkland, James L., Monroe, David G., and Khosla, Sundeep

Abstract

Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including bone loss. Thus, we conducted a phase 2 randomized controlled trial of intermittent administration of the senolytic combination dasatinib plus quercetin (D + Q) in postmenopausal women (n= 60 participants). The primary endpoint, percentage changes at 20 weeks in the bone resorption marker C-terminal telopeptide of type 1 collagen (CTx), did not differ between groups (median (interquartile range), D + Q −4.1% (−13.2, 2.6), control −7.7% (−20.1, 14.3); P= 0.611). The secondary endpoint, percentage changes in the bone formation marker procollagen type 1 N-terminal propeptide (P1NP), increased significantly (relative to control) in the D + Q group at both 2 weeks (+16%, P= 0.020) and 4 weeks (+16%, P= 0.024), but was not different from control at 20 weeks (−9%, P= 0.149). No serious adverse events were observed. In exploratory analyses, the skeletal response to D + Q was driven principally by women with a high senescent cell burden (highest tertile for T cell p16(also known as CDKN2A) mRNA levels) in which D + Q concomitantly increased P1NP (+34%, P= 0.035) and reduced CTx (−11%, P= 0.049) at 2 weeks, and increased radius bone mineral density (+2.7%, P= 0.004) at 20 weeks. Thus, intermittent D + Q treatment did not reduce bone resorption in the overall group of postmenopausal women. However, our exploratory analyses indicate that further studies are needed testing the hypothesis that the underlying senescent cell burden may dictate the clinical response to senolytics. ClinicalTrials.gov identifier: NCT04313634.

Published
2024
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15. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Author

Samakkarnthai, Parinya, primary, Saul, Dominik, additional, Zhang, Lei, additional, Aversa, Zaira, additional, Doolittle, Madison L., additional, Sfeir, Jad G., additional, Kaur, Japneet, additional, Atkinson, Elizabeth J., additional, Edwards, James R., additional, Russell, Graham G., additional, Pignolo, Robert J., additional, Kirkland, James L., additional, Tchkonia, Tamar, additional, Niedernhofer, Laura J., additional, Monroe, David G., additional, Lebrasseur, Nathan K., additional, Farr, Joshua N., additional, Robbins, Paul D., additional, and Khosla, Sundeep, additional

Published
2023
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20. In vitroandin vivoeffects of zoledronate on senescence and senescence-associated secretory phenotype markers

Author

Samakkarnthai, Parinya, primary, Saul, Dominik, additional, Zhang, Lei, additional, Aversa, Zaira, additional, Doolittle, Madison L., additional, Sfeir, Jad G., additional, Kaur, Japneet, additional, Atkinson, Elizabeth J, additional, Edwards, James R., additional, Russell, R. Graham G., additional, Pignolo, Robert J., additional, Kirkland, James L., additional, Tchkonia, Tamar, additional, Niedernhofer, Laura J., additional, Monroe, David G., additional, LeBrasseur, Nathan K., additional, Farr, Joshua N., additional, Robbins, Paul D., additional, and Khosla, Sundeep, additional

Published
2023
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23. Targeting cellular senescence prevents age-related bone loss in mice

Author

Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, and Khosla, Sundeep

Subjects
Osteoporosis -- Genetic aspects -- Prevention -- Research, Cell aging -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Author(s): Joshua N Farr [1]; Ming Xu [1]; Megan M Weivoda [1]; David G Monroe [1]; Daniel G Fraser [1]; Jennifer L Onken [1]; Brittany A Negley [1]; Jad G [...]

Published
2017
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29. List of Contributors

Author

Ahmad, Christopher S., Aisen, Mindy, Allen, Jason, Alon, Gad, Aloni, Ronit, Amin, Mayur Jayant, Ang-Muñoz, Cynthia D., Argoff, Charles E., Atanelov, Levi (Levan), Ayyangar, Rita, Bach, John R., Bačkonja, Miroslav Misha, Baggett, Leela, Barr, Karen P., Barrett, J. Christian, Bartels, Matthew, Basford, Jeffrey R., Bastepe-Gray, Serap, Beheshti, Mahya, Benjamin, Scott E., Bergin, William A., Bhatti, Omar Maurice, Bhullar, Ravneet, Bialek, Amy, Boninger, Michael L., Borg-Stein, Joanne, Brady, Susan, Brooke, Marvin McClatchey, Brown, Scott E., Brown, Steven E., Bukovitz, Brandon, Cabahug, Philippines G., Carson, Benjamin S., Sr., Cassius, David A., Chan, Leighton, Chan, Stephanie, Cicone, Caitlin M., Cohen, Jeffrey, Cooper, Rory A., Corrales, Alberto G., Cowling, Matthew, Cuccurullo, Sara, Cymet, Tyler C., Delaney, Kate E., Delavaux, Laurent, Sena, Giampaolo de, DeStefano, Lisa, Devon, Rubin I., Dillingham, Timothy R., Donofrio, Peter Daniel, Dreher, Freda, Duarte, Andrew J., Tan Dy, Rochelle Coleen, Ellenberg, Maury Ruben, Falco, Frank J.E., Filatov, Sergey, Findley, Thomas, Finnegan, Mark, Flamm, Michael, Flanagan, Steven, Furman, Michael B., Gabriel, Vincent, Ganchoon, Filipinas G., Gellhorn, Alfred C., Gharibo, Christopher, Gillis, Theresa A., Gimigliano, Francesca, Goetz, Lance L., Goldberg, Gary, Goldberg, Stephen, Gonzalez-Fernandez, Marlis, Grant, Ryan A., Habibi, Behnum, Hakimi, Kevin, Harvey, Richard L., Heckman, Jeffrey T., Heinle, Edward W., III, Helms, Joseph M., Heruti, Rafi J., Hinderer, Steven R., Ho, Chun, Honce, Bethany, Howard, Ileana Michelle, Huang, DongFeng, Hurvitz, Edward A., Iafrate, Julia Louisa, Ibanez, Katarzyna, Imamura, Marta, Ito, Akiko, Jackson, Kristen, Jones, Paul Steven, Joyce, Nanette Cunningham, Kalva, Shailaja, Kane, Chelsea, Katz, Richard T., Kerrigan, Deidre Casey, Khalid, Ehtesham, Khan, Fary, Khurana, Seema, Kiekens, Carlotte, Kim, Charles, Kiprovski, Kiril, Kirby, R. Lee, Knudsen, Michael L., Kolessar, David J., König, Franchesca, Korth, Sarah A., Koutalianos, Evangeline P., Kowalske, Karen J., Lains, Jorge, Ledbetter, David H., Lehman, Jeffrey, Lehman, Yehoshua J., Leonard, James W., Levy, Charles Edward, Lew, Karen, Li, Leonard S.W., Limke, Janet C., Littell, Kyle, Lopez, Francis, Mastanduno, Samantha, McGunigal, Thomas, Meyers, Jeffrey Saul, Mitchkash, Matthew, Mojica, Jose Alvin, Moroz, Alex, Myers, Stanley J., Nally, Emma, Napier, Fabreena E., Rao, Noel, Nosek, Margaret A., Odderson, Ib R., O’Young, Bryan J., Parikh, Sagar, Pazionis, Theresa J.C., Perkash, Inder, Pignolo, Robert, Poliak-Tunis, Michelle A., Press, Joel M., Priebe, Michael, Pruente, Jessica, Pruski, April D., Raghavan, Preeti, Rashbaum, Ira G., Ratan, Rajiv R., Recio, Albert, Richardson, James P., Rizzo, John-Ross, Robinson, Lawrence R., Rodriguez, Gianna Maria, Rodriguez, Rosa, Rondinelli, Robert, Rossi, Roger P., Rowan, Jacob, Rudin, Nathan J., Rundorff, Robert, Roza, Ryan J., Ryan-Michailidis, Emily, Saulle, Michael Frederick, Schneck, Carson D., Schneider, Jeffrey C., Schultz, Shannon L., Schwartz, Robert G., Sfeir, Jad Georges, Shafshak, Tarek, Shah, Jay P., Shamberg, Shoshana, Shapiro, Jennifer, Dave, Shashank, Siddiqi, Asad Riaz, Silver, Kenneth H., Slotkin, Jonathan R., Smith, Cher, Soares, Bosco Francisco, Soroker, Nachum, Speckman, Rebecca A., Stecco, Antonio, Stecco, Carla, Stein, Joel, Stern, Michelle, Sturgeon, John A., Sthalekar, Ninad Durganand, Stiens, Beth, Stiens, Steven A., Stiens, Elizabeth A., Stineman, Margaret Grace, Stover, Gary, Jr., Strauss, Constance L., Strauss, Nancy, Strayer, Jonathan, Suputtitada, Areerat, Tepper, Mitchell S., Terzella, Matthew, Terzic, Carmen M., Thakral, Aakash, Thakur, Lokendra, Thomas, Peter, Tippett, Donna C., Trasolini, Robert G., Trovato, Melissa, Tunis, Justin G., Uustal, Heikki, de Walle, Naheed Asad-Van, Dien, Craig Van, Varlotta, Gerard P., Visco, Christopher J., Vivekanandan, Sheela, Wainapel, Stanley F., Wang, Ninghua, Westheimer, Ruth, Whiteson, Jonathan H., Williams, Marc S., Williams, Olajide, Wortman-Jutt, Susan, Wu, Sam S.H., York, Henry S., Young, Mark A., Young, Marlene, Young, Michael J., Yuan, Xiaoning (Jenny), Zaremski, Jason L., and Zorowitz, Richard D.

Published
2024
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33. Determinants of Bone Material Strength and Cortical Porosity in Patients with Type 2 Diabetes Mellitus

Author

Samakkarnthai, Parinya, primary, Sfeir, Jad G, additional, Atkinson, Elizabeth J, additional, Achenbach, Sara J, additional, Wennberg, Paul W, additional, Dyck, Peter J, additional, Tweed, Amanda J, additional, Volkman, Tammie L, additional, Amin, Shreyasee, additional, Farr, Joshua N, additional, Vella, Adrian, additional, Drake, Matthew T, additional, and Khosla, Sundeep, additional

Published
2020
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40. Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice

Author

Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, and Khosla, Sundeep

Subjects
Biological sciences, Health
Abstract

Author(s): Joshua N Farr; Ming Xu; Megan M Weivoda; David G Monroe; Daniel G Fraser; Jennifer L Onken; Brittany A Negley; Jad G Sfeir; Mikolaj B Ogrodnik; Christine M Hachfeld; [...]

Published
2017
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44. Erratum: Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice

Author

Farr, Joshua N, primary, Xu, Ming, additional, Weivoda, Megan M, additional, Monroe, David G, additional, Fraser, Daniel G, additional, Onken, Jennifer L, additional, Negley, Brittany A, additional, Sfeir, Jad G, additional, Ogrodnik, Mikolaj B, additional, Hachfeld, Christine M, additional, LeBrasseur, Nathan K, additional, Drake, Matthew T, additional, Pignolo, Robert J, additional, Pirtskhalava, Tamar, additional, Tchkonia, Tamara, additional, Oursler, Merry Jo, additional, Kirkland, James L, additional, and Khosla, Sundeep, additional

Published
2017
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