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WOS: 000248794000005 PubMed: 17294139 Background No-reflow developed after coronary revascularization is an independent predictor of in-hospital mortality and poor clinical outcome. In this study, we investigated the difference between direct stenting and stenting with predilation, regarding to development of no-reflow in patients with acute coronary syndromes (ACS) and the role of fibrinolytic system in that phenomenon. Methods Fifty eight patients with the diagnosis of ACS in whom percutaneous coronary intervention (PCI) was applied were included in study. Patients were divided into two groups according to stent application with and without predilation. Pre- and post-intervention corrected TIMI frame counts (cTFC) were calculated. Post-PCI plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), plasminogen and D-Dimer levels were measured. Results Pre-intervention cTFC values were similar between stenting with and without predilation groups (P > 0.05). There was a significant decrease in post-intervention cTFC values in both groups (P < 0.002 and P < 0.05, respectively). But, there was no significant difference between post-intervention cTFC values of the groups, regardless to stent implantation techniques. (P > 0.05). In patients having high cTFC values compared with having low cTFC values; PAI-1 (P = 0.002), tPA (P = 0.015), plasminogen (P = 0.040) and D-dimer (P = 0.049) levels were significantly higher. Also, significant relationship was determined between cTFC and PAI-1, tPA, plasminogen, D-dimer levels (P values 0.003

Pinarli, Faruk Guclu/0000-0002-3241-2478 WOS: 000236144100004 PubMed: 16651239 Acquired von Willebrand syndronze is a rare bleeding disorder with clinical and laboratory features closely resembling to hereditary von Willebrand disease. The syndrome may accompany various conditions, including malignant disorders, most often with Wilms tumor and adrenal cell carcinoma. In this report, the authors present a patient with AvWS in association with Ewing sarcoma for the first time in the literature. The abnormal bleeding tendency was successfully treated with fresh frozen plasma and did not recur after the first two courses of chemotherapy with clinical improvement.

39th Annual Meeting of the European-Society-for-Paediatric-Nephrology -- SEP 10-13, 2005 -- Istanbul, TURKEY ozkaya, ozan/0000-0002-0198-1221; BEK, KENAN/0000-0002-1005-2379 WOS: 000239818100010 PubMed: 16810511 Acquired deficiency of anticoagulant proteins, due to loss in the urine, has been proposed as one of the major thrombogenic alterations in nephrotic syndrome (NS). Protein Z (PZ) is a single-chain vitamin K-dependent glycoprotein. Low PZ levels are reported to be a risk factor for thrombosis. The aim of this study was to investigate protein Z and other natural anticoagulant levels in children with NS. Thirty children aged between 1.5 and 12 years with NS (Groups I and II) and 19 age- and-sex-matched healthy controls (Group III) were enrolled into the study. Patients were divided into two groups: Group I (proteinuria > 40 mg/ m(2)/ hr) and Group II (patients in remission). Plasma PZ levels in Group I were significantly lower than Group II (p = 0.009) and group III (p = 0.018). Plasma levels of AT III for Group I were significantly lower than for Groups II and III (p = 0.009, p = 0.005, respectively). Protein C levels in Group I were higher than in Group II and Group III (p = 0.002, p = 0.000, respectively). Protein Z levels positively correlated with serum total protein and albumin levels (p = 0.003, p = 0.003, respectively) and negatively with the degree of proteinuria (p= 0.000). Protein Z levels were positively correlated with AT III (r = 0.037, p = 0.04). Along with the other coagulation abnormalities, decreased protein Z may contribute to increased risk of thromboembolic complications in children with NS. The negative correlation between proteinuria and PZ level suggests the possibility of renal PZ loss. Further studies are needed to investigate the mechanism and role of decreased PZ in NS. European Soc Paediat Nephrol