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2. BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Author

Dudnik, Alexey, Almeida, A. Filipa, Andrade, Ricardo, Avila, Barbara, Bañados, Pilar, Barbay, Diane, Bassard, Jean-Etienne, Benkoulouche, Mounir, Bott, Michael, Braga, Adelaide, Breitel, Dario, Brennan, Rex, Bulteau, Laurent, Chanforan, Celine, Costa, Inês, Costa, Rafael S., Doostmohammadi, Mahdi, Faria, Nuno, Feng, Chengyong, Fernandes, Armando, Ferreira, Patricia, Ferro, Roberto, Foito, Alexandre, Freitag, Sabine, Garcia, Gonçalo, Gaspar, Paula, Godinho-Pereira, Joana, Hamberger, Björn, Hartmann, András, Heider, Harald, Jardim, Carolina, Julien-Laferriere, Alice, Kallscheuer, Nicolai, Kerbe, Wolfgang, Kuipers, Oscar P., Li, Shanshan, Love, Nicola, Marchetti-Spaccamela, Alberto, Marienhagen, Jan, Martin, Cathie, Mary, Arnaud, Mazurek, Vincent, Meinhart, Camillo, Sevillano, David Méndez, Menezes, Regina, Naesby, Michael, Nørholm, Morten H. H., Okkels, Finn T., Oliveira, Joana, Ottens, Marcel, Parrot, Delphine, Pei, Lei, Rocha, Isabel, Rosado-Ramos, Rita, Rousseau, Caroline, Sagot, Marie-France, dos Santos, Claudia Nunes, Schmidt, Markus, Shelenga, Tatiana, Shepherd, Louise, Silva, Ana Rita, da Silva, Marcelo Henriques, Simon, Olivier, Stahlhut, Steen Gustav, Solopova, Ana, Sorokin, Artem, Stewart, Derek, Stougie, Leen, Su, Shang, Thole, Vera, Tikhonova, Olga, Trick, Martin, Vain, Philippe, Veríssimo, André, Vila-Santa, Ana, Vinga, Susana, Vogt, Michael, Wang, Liangsheng, Wang, Lijin, Wei, Wei, Youssef, Sandra, Neves, Ana Rute, and Forster, Jochen

Published
2018
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7. BacHBerry:BACterial hosts for production of bioactive phenolics from bERRY fruits

Author

Dudnik, Alexey, Almeida, A. Filipa, Andrade, Ricardo, Avila, Barbara, Bañados, Pilar, Barbay, Diane, Bassard, Jean-Étienne André, Benkoulouche, Mounir, Bott, Michael, Braga, Adelaide, Breitel, Dario, Brennan, Rex, Bulteau, Laurent, Chanforan, Celine, Costa, Inês, Costa, Rafael S., Doostmohammadi, Mahdi, Faria, Nuno, Feng, Chengyong, Fernandes, Armando, Ferreira, Patricia, Ferro, Roberto, Foito, Alexandre, Freitag, Sabine, Garcia, Gonçalo, Gaspar, Paula, Godinho-Pereira, Joana, Hamberger, Björn Robert, Hartmann, András, Heider, Harald, Jardim, Carolina, Julien-Laferriere, Alice, Kallscheuer, Nicolai, Kerbe, Wolfgang, Kuipers, Oscar P., Li, Shanshan, Love, Nicola, Marchetti-Spaccamela, Alberto, Marienhagen, Jan, Martin, Cathie, Mary, Arnaud, Mazurek, Vincent, Meinhart, Camillo, Sevillano, David Méndez, Menezes, Regina, Naesby, Michael, Nørholm, Morten H.H., Okkels, Finn T., Stahlhut, Steen Gustav, Vogt, Michael, Dudnik, Alexey, Almeida, A. Filipa, Andrade, Ricardo, Avila, Barbara, Bañados, Pilar, Barbay, Diane, Bassard, Jean-Étienne André, Benkoulouche, Mounir, Bott, Michael, Braga, Adelaide, Breitel, Dario, Brennan, Rex, Bulteau, Laurent, Chanforan, Celine, Costa, Inês, Costa, Rafael S., Doostmohammadi, Mahdi, Faria, Nuno, Feng, Chengyong, Fernandes, Armando, Ferreira, Patricia, Ferro, Roberto, Foito, Alexandre, Freitag, Sabine, Garcia, Gonçalo, Gaspar, Paula, Godinho-Pereira, Joana, Hamberger, Björn Robert, Hartmann, András, Heider, Harald, Jardim, Carolina, Julien-Laferriere, Alice, Kallscheuer, Nicolai, Kerbe, Wolfgang, Kuipers, Oscar P., Li, Shanshan, Love, Nicola, Marchetti-Spaccamela, Alberto, Marienhagen, Jan, Martin, Cathie, Mary, Arnaud, Mazurek, Vincent, Meinhart, Camillo, Sevillano, David Méndez, Menezes, Regina, Naesby, Michael, Nørholm, Morten H.H., Okkels, Finn T., Stahlhut, Steen Gustav, and Vogt, Michael

Abstract

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Published
2018

8. Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington’s Disease

Author

Kallscheuer, Nicolai, primary, Menezes, Regina, additional, Foito, Alexandre, additional, da Silva, Marcelo Henriques, additional, Braga, Adelaide, additional, Dekker, Wijbrand, additional, Sevillano, David Méndez, additional, Rosado-Ramos, Rita, additional, Jardim, Carolina, additional, Oliveira, Joana, additional, Ferreira, Patrícia, additional, Rocha, Isabel, additional, Silva, Ana Rita, additional, Sousa, Márcio, additional, Allwood, J. William, additional, Bott, Michael, additional, Faria, Nuno, additional, Stewart, Derek, additional, Ottens, Marcel, additional, Naesby, Michael, additional, Nunes dos Santos, Cláudia, additional, and Marienhagen, Jan, additional

Published
2018
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9. BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Author

Dudnik, Alexey, primary, Almeida, A. Filipa, additional, Andrade, Ricardo, additional, Avila, Barbara, additional, Bañados, Pilar, additional, Barbay, Diane, additional, Bassard, Jean-Etienne, additional, Benkoulouche, Mounir, additional, Bott, Michael, additional, Braga, Adelaide, additional, Breitel, Dario, additional, Brennan, Rex, additional, Bulteau, Laurent, additional, Chanforan, Celine, additional, Costa, Inês, additional, Costa, Rafael S., additional, Doostmohammadi, Mahdi, additional, Faria, Nuno, additional, Feng, Chengyong, additional, Fernandes, Armando, additional, Ferreira, Patricia, additional, Ferro, Roberto, additional, Foito, Alexandre, additional, Freitag, Sabine, additional, Garcia, Gonçalo, additional, Gaspar, Paula, additional, Godinho-Pereira, Joana, additional, Hamberger, Björn, additional, Hartmann, András, additional, Heider, Harald, additional, Jardim, Carolina, additional, Julien-Laferriere, Alice, additional, Kallscheuer, Nicolai, additional, Kerbe, Wolfgang, additional, Kuipers, Oscar P., additional, Li, Shanshan, additional, Love, Nicola, additional, Marchetti-Spaccamela, Alberto, additional, Marienhagen, Jan, additional, Martin, Cathie, additional, Mary, Arnaud, additional, Mazurek, Vincent, additional, Meinhart, Camillo, additional, Sevillano, David Méndez, additional, Menezes, Regina, additional, Naesby, Michael, additional, Nørholm, Morten H. H., additional, Okkels, Finn T., additional, Oliveira, Joana, additional, Ottens, Marcel, additional, Parrot, Delphine, additional, Pei, Lei, additional, Rocha, Isabel, additional, Rosado-Ramos, Rita, additional, Rousseau, Caroline, additional, Sagot, Marie-France, additional, dos Santos, Claudia Nunes, additional, Schmidt, Markus, additional, Shelenga, Tatiana, additional, Shepherd, Louise, additional, Silva, Ana Rita, additional, da Silva, Marcelo Henriques, additional, Simon, Olivier, additional, Stahlhut, Steen Gustav, additional, Solopova, Ana, additional, Sorokin, Artem, additional, Stewart, Derek, additional, Stougie, Leen, additional, Su, Shang, additional, Thole, Vera, additional, Tikhonova, Olga, additional, Trick, Martin, additional, Vain, Philippe, additional, Veríssimo, André, additional, Vila-Santa, Ana, additional, Vinga, Susana, additional, Vogt, Michael, additional, Wang, Liangsheng, additional, Wang, Lijin, additional, Wei, Wei, additional, Youssef, Sandra, additional, Neves, Ana Rute, additional, and Forster, Jochen, additional

Published
2017
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10. Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease.

Author

Kallscheuer, Nicolai, Menezes, Regina, Foito, Alexandre, da Silva, Marcelo Henriques, Braga, Adelaide, Dekker, Wijbrand, Sevillano, David Méndez, Rosado-Ramos, Rita, Jardim, Carolina, Oliveira, Joana, Ferreira, Patrícia, Rocha, Isabel, Silva, Ana Rita, Sousa, Márcio, Allwood, J. William, Bott, Michael, Faria, Nuno, Stewart, Derek, Ottens, Marcel, and Naesby, Michael

Published
2019
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11. Model Comparison for the Prediction of the Solubility of Green Tea Catechins in Ethanol/Water Mixtures

Author

Sevillano, David Méndez, van der Wielen, Luuk A. M., Trifunovic, Olivera, and Ottens, Marcel

Abstract

This article evaluates some of the most used solubility models and their applicability to antioxidants, namely, the family of catechins. From the list of possible catechins, the main four were selected for this study: epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate. Both the enthalpy of fusion and melting temperature were measured experimentally for these four molecules and compared with the values obtained using predictive methods. Solubility measurements for mixtures of water and ethanol were performed with high-throughput experimentation at temperatures of 293 and 303 K. The experiments show a strong nonideal behavior in both pure and mixed solvents. A comparison of different models was performed, identifying the advantages and disadvantages of each model and their performance in this particular case. Finally, the NRTL-SAC model was found to be the most accurate model for predicting solubility, with an RMSE of 0.550.

Published
2024
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