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3. Effects of tranexamic acid and bipolar sealer alone or in combination in primary total knee arthroplasty: a prospective, randomized, controlled trial

Author

Irwin Gross, Stephen M. Walsh, Alexandru Seviciu, and Samreen Fathima

Subjects
musculoskeletal diseases, medicine.medical_specialty, Tranexamic acid, Blood management, Total knee arthroplasty, 030204 cardiovascular system & hematology, Bipolar sealer system, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Blood loss, lcsh:Orthopedic surgery, law, medicine, Orthopedics and Sports Medicine, Original Research, 030222 orthopedics, business.industry, musculoskeletal system, Surgery, Hemoglobin change, lcsh:RD701-811, Anesthesia, sense organs, business, medicine.drug
Abstract

Background: The purpose of this study was to compare 2 blood management interventions, tranexamic acid (TXA) and bipolar sealer system (BSS) used independently or in combination with a control group during primary total knee arthroplasty (TKA). Methods: A total of 127 TKA patients were enrolled and randomized into 4 groups: Intravenous TXA plus the BSS (N = 29, group 1); TXA only (N = 29, group 2); BSS only (N = 31, group 3); and intravenous normal saline as a control group (N = 32, group 4). Results: Changes in hemoglobin from baseline to postoperative follow-up were significantly lower among patients who received TXA plus BSS and those receiving TXA only when compared with the control. BSS only did not differ significantly when compared to the control group. In addition, TXA plus BSS was as efficacious as TXA only in preserving postoperative hemoglobin. Conclusions: In other terms, using bipolar sealer did not add to the effect of TXA in reducing the postoperative hemoglobin drop in primary TKA.

Published
2016

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