47 results on '"Sevgi T"'
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2. Evaluation of the Hand Grip and Sheet Rope Pulling Strength in Laser Sailing Athletes by Using Hiking Bench
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Sevgi Tuncel, İrfan Gülmez, Muhammed Yusuf Kahraman, Fatih Sani, and Nusret Ramazanoğlu
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Sports ,GV557-1198.995 - Abstract
This study aimed to investigate hand grip and rope-pulling strength and endurance in laser-class sailors. Seventeen laser class sailors, 15 males and two females participated in this study voluntarily. Hand grip and sheet rope-pulling tests were performed on the hiking bench. To determine the hand grip and the sheet rope-pulling strength, the loadcell and Strength Sensor Platform software were used. No significant correlation was observed between the hand grip and sheet rope-pulling strength (p > .05). A positive correlation was observed between the strengths of two hands in hand grip and sheet rope pulling (p < .01). According to endurance levels, the main effect of Force × Side interaction was significant (p=.038). For post hoc tests, sheet rope-pulling endurance was higher than the hand grip and the left was higher than the right hand grip. In conclusion, a significant correlation was observed between right and left hand grip strength. Anthropometric parameters, particularly body mass index, have a significant relationship with hand grip strength, probably due to increased muscle mass. Furthermore, significant differences in endurance levels were observed in hand grip and rope-pulling, as well as between the right and left hands. These findings highlight the importance of integrating hand grip endurance activities into training to reduce asymmetric endurance levels.
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- 2024
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3. Closed–loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study
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Gulhan Atakul, Gokhan Ceylan, Ozlem Sandal, Ekin Soydan, Pinar Hepduman, Mustafa Colak, Jan M. Zimmermann, Dominik Novotni, Utku Karaarslan, Sevgi Topal, and Hasan Aǧin
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hypoxemia ,oxygen therapy ,invasive mechanical ventilation ,automation ,closed-loop ,oxygen controller ,Medicine (General) ,R5-920 - Abstract
BackgroundThe aim of this study is the evaluation of a closed-loop oxygen control system in pediatric patients undergoing invasive mechanical ventilation (IMV).MethodsCross-over, multicenter, randomized, single-blind clinical trial. Patients between the ages of 1 month and 18 years who were undergoing IMV therapy for acute hypoxemic respiratory failure (AHRF) were assigned at random to either begin with a 2-hour period of closed-loop oxygen control or manual oxygen titrations. By using closed-loop oxygen control, the patients' SpO2 levels were maintained within a predetermined target range by the automated adjustment of the FiO2. During the manual oxygen titration phase of the trial, healthcare professionals at the bedside made manual changes to the FiO2, while maintaining the same target range for SpO2. Following either period, the patient transitioned to the alternative therapy. The outcomes were the percentage of time spent in predefined SpO2 ranges ±2% (primary), FiO2, total oxygen use, and the number of manual adjustments.FindingsThe median age of included 33 patients was 17 (13–55.5) months. In contrast to manual oxygen titrations, patients spent a greater proportion of time within a predefined optimal SpO2 range when the closed-loop oxygen controller was enabled (95.7% [IQR 92.1–100%] vs. 65.6% [IQR 41.6–82.5%]), mean difference 33.4% [95%–CI 24.5–42%]; P < 0.001). Median FiO2 was lower (32.1% [IQR 23.9–54.1%] vs. 40.6% [IQR 31.1–62.8%]; P < 0.001) similar to total oxygen use (19.8 L/h [IQR 4.6–64.8] vs. 39.4 L/h [IQR 16.8–79]; P < 0.001); however, median SpO2/FiO2 was higher (329.4 [IQR 180–411.1] vs. 246.7 [IQR 151.1–320.5]; P < 0.001) with closed–loop oxygen control. With closed–loop oxygen control, the median number of manual adjustments reduced (0.0 [IQR 0.0–0.0] vs. 1 [IQR 0.0–2.2]; P < 0.001).ConclusionClosed-loop oxygen control enhances oxygen therapy in pediatric patients undergoing IMV for AHRF, potentially leading to more efficient utilization of oxygen. This technology also decreases the necessity for manual adjustments, which could reduce the workloads of healthcare providers.Clinical Trial RegistrationThis research has been submitted to ClinicalTrials.gov (NCT05714527).
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- 2024
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4. Bullying Prevention in Turkish Schools: Evaluation of the ViSC Program
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Aysun Doğan, Sevgi T. Aytekin, and Dagmar Strohmeier
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- 2022
5. Confirmation of Nasogastric Tube Placement via Bedside Ultrasound in a Pediatric Intensive Care Unit
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Mustafa Çolak, Gökhan Ceylan, Sevgi Topal, Özlem Saraç Sandal, Gülhan Atakul, Ekin Soydan, Pınar Hepduman, Utku Kararslan, and Hasan Ağın
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nasogastric tube ,pediatric intensive care units ,radiography ,ultrasonography ,Medicine - Abstract
Introduction: Nasogastric tube (NGT) placement is a common procedure in pediatric intensive care and requires accurate verification to avoid complications. Traditional methods such as auscultation and radiography pose limitations such as unreliability and radiation exposure. The aim of this study was to confirm the placement of NGT using bedside ultrasonography (USG). Methods: A prospective study was conducted in a tertiary pediatric intensive care unit (PICU) using bedside USG to confirm NGT positioning. The study included 46 patients, with procedures ranging from November 2023 to January 2024. Placement confirmation techniques included USG visualization and the air bolus method when necessary. Results: All 68 NGT insertions were successfully visualized using USG. The median age of patients was 18 months, with the most common admissions being pneumonia and septic shock. An air bolus was used in 13.2% of the cases to indirectly confirm placement. Conclusion: Bedside USG is an effective and safe alternative for confirming NGT placement in the PICU, minimizing the risk of radiation, and leveraging the benefits of immediate and accurate bedside assessment. This method can replace radiography as the new standard for NGT placement confirmation.
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- 2024
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6. Assessment and Evaluation of Cardiology Residency Training in Türkiye: A National Survey
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Aylin Yıldırır and Sevgi Turan
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assessment and evaluation ,cardiology training ,survey ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Workplace-based assessment methods are essential in the assessment and evaluation of competency-based cardiology residency training. This study aims to determine the assessment and evaluation methods used in cardiology residency training in Türkiye and to reach the opinions of the institutions on the applicability of the workplace-based assessments. Methods: In this descriptive study, a Google Survey was sent to the heads/trainers of residency educational centers and their opinions about the currently used assessment and evaluation methods, applicability of cardiology competency exams, and the workplace-based assessments were asked. Results: Responses were received from 65 (76.5%) of 85 training centers. Of the centers, 89.2% reported using resident report cards, 78.5% case-based discussion, 78.5% direct observation of procedural skills, 69.2% multiple-choice questions, 60% traditional oral exams, and less commonly other exam types. About 74% of responders gave a positive opinion on the requirement of being successful in the Turkish Cardiology Competency knowledge exam before specialty. Case-based discussion was the most common work-place-based assessments that the centers think could be applied as suggested by the current literature. A common idea was the adaptation of workplace-based assessments based on international standards and our national norms. The trainers supported a nationwide examination for all training centers to ensure standardization. Conclusion: In Türkiye, it was promising to see that the trainers are positive about the applicability of workplace-based assessments, but they commonly thought that the proposed workplace-based assessments should be adapted before nationwide applicability. Medical educators and field experts need to work together on this issue.
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- 2023
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7. Does Endotracheal Suctioning Affect Bispectral Index and Ramsay Sedation Scores in Pediatric Intensive Care Patients?
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Gülhan Atakul, Gökhan Ceylan, Özlem Saraç Sandal, Ferhat Sarı, Sevgi Topal, Mustafa Çolak, Ekin Soydan, Utku Karaarslan, Rana İşgüder, and Hasan Ağın
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analgesia ,pain ,pediatrics ,critical care ,conscious sedation ,bispectral index ,Pediatrics ,RJ1-570 - Abstract
Objective: A particular electroencephalography parameter known as the bispectral index (BIS) is one of the objective methods used to assess sedative and hypnotic effects. The aim of this study is to monitor the level of consciousness of patients who underwent sedation-analgesia in pediatric intensive care unit (PICU) and to evaluate how their sedation levels were affected by painful procedures by examining BIS and Ramsey Sedation Scale (RSS). Method: This prospective observational study was held 43 pediatric patients who were hospitalized in the 24-bed university-affiliated tertiary PICU. BIS, RSS and vital signs were recorded both before and after the endotracheal suctioning procedure. Patients were divided into two groups according to the chosen analgesic which was fentanyl or morphine. Percentage change (BIS, electromyography activity, signal quality index, RSS score, heart rate, oxygen saturation) of before/after endotracheal suctioning was calculated. Results: The increase in BIS value, increase heart rates and decrease RSS of patients with endotracheal suctioning were found to be significant (p
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- 2023
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8. A Practical Approach to Super Refractory Status Epilepticus in Pediatric Intensive Care Unit
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Ekin Soydan, Ahmet Gönüllü, Yiğit Aksoy, Yiğithan Güzin, Gökhan Ceylan, Pınar Seven, Mustafa Çolak, Sevgi Topal, Gülhan Atakul, Özlem Saraç Sandal, Utku Karaarslan, Aycan Ünalp, and Hasan Ağın
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super refractory status epilepticus ,continuous electroencephalographic monitoring ,non-convulsive status epilepticus ,febrile infection-related epilepsy syndrome ,pediatric intensive care unit ,Pediatrics ,RJ1-570 - Abstract
Objective: In this study, we aimed to evaluate the demographic, clinical features, long-term electroencephalography (EEG) findings and treatment modalities of pediatric patients with super refractory status epilepticus (SRSE). Method: A retrospective, observational study was conducted in patients diagnosed as SRSE between 1 June 2018 and 30 May 2021 in the pediatric intensive care unit. Patients with SRSE between 1 month and 18 years of age who underwent continuous electroencephalogram (cEEG) monitoring were included in the study. Demographic data, clinical, and electroencephalographic characteristics were collected. Results: A total of 11 patients were included in the study. The median age of the patients was 31 months (IQR 8-72 months). Nine (81.8%) patients had symptomatic etiology. Of the symptomatic etiologies, 4 (36.3%) patients had acute symptomatic, 3 (27.2%) patients had remote symptomatic and 2 (18.2%) patients had progressive etiology. The most common etiology was immune-related. The median cEEG duration of the patients was 60 hours (IQR 52-72 hours). Midazolam infusion was given to 11 (100%) patients, ketamine infusion was given to 9 (81.8%) patients, thiopental infusion was given to 6 (54.5%) patients, and propofol infusion was given to 2 (18.1%) patients as coma induction treatment. Intravenous immunoglobulin, corticosteroid and plasmapheresis were administered to 3 (27.2%) patients with immune etiology. The overall mortality was 18.1%. Conclusion: SRSE is a neurological emergency with high mortality and morbidity. cEEG monitoring is very important in diagnosis and treatment. Immune etiology should be considered in long-lasting seizures, especially if they are resistant to anesthetics. The immunomodulatory therapy should be started.
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- 2023
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9. Evaluation of renal near-infrared spectroscopy for predicting extubation outcomes in the pediatric intensive care setting
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Mustafa Colak, Gokhan Ceylan, Sevgi Topal, Ozlem Sarac Sandal, Gulhan Atakul, Ekin Soydan, Ferhat Sarı, Pinar Hepduman, Utku Karaarslan, and Hasan Ağın
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extubation readiness test ,mechanical ventilation ,near-infrared spectroscopy ,noninvasive monitoring ,pediatric intensive care ,Pediatrics ,RJ1-570 - Abstract
BackgroundIn pediatric intensive care units, extubation failure following invasive mechanical ventilation poses significant health risks. Determining readiness for extubation in children can minimize associated morbidity and mortality. This study investigates the potential role of renal near-infrared spectroscopy (RrSO2) in predicting extubation failure in pediatric patients.MethodsA total of 84 patients aged between 1 month and 18 years, mechanically ventilated for at least 24 h, were included in this prospective study. RrSO2 levels were measured using near-infrared spectroscopy before and during an extubation readiness test (ERT). The primary outcome measure was extubation failure, defined as a need for reintubation within 48 h.ResultsOf the 84 patients, 71 (84.6%) were successfully extubated, while 13 (15.4%) failed extubation. RrSO2 was found to be lower in the failed extubation group, also decrease in RrSO2 values during ERT was significantly greater in patients with extubation failure. ROC analysis indicated a decrease in ΔRrSO2 of more than 6.15% from baseline as a significant predictor of extubation failure, with a sensitivity of 0.984 and a specificity of 0.889.ConclusionMonitoring changes in RrSO2 values may serve as a helpful tool to predict extubation failure in pediatric patients. Further multi-center research is warranted to improve the generalizability and reliability of these findings.
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- 2024
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10. Evaluation of nutritional status in pediatric intensive care unit patients: the results of a multicenter, prospective study in Turkey
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Merve Misirlioglu, Dincer Yildizdas, Faruk Ekinci, Ozden Ozgur Horoz, Gokhan Tumgor, Ahmet Yontem, Mehmet Nur Talay, Murat Kangin, Erennur Tufan, Selman Kesici, Nazik Yener, Hatice Elif Kinik Kaya, Merve Havan, Ali Tunc, Nihal Akçay, Esra Sevketoglu, Fatih Durak, Aysenur Ozel Dogruoz, Serhan Ozcan, Oktay Perk, Muhterem Duyu, Merve Boyraz, Mutlu Uysal Yazici, Zeynelabidin Ozturk, Mehmet Çeleğen, Aysegul Bukulmez, Ebru Kacmaz, Ener Cagri Dinleyici, Oguz Dursun, Alper Koker, Suleyman Bayraktar, Mey Talip Petmezci, Aygul Nabaliyeva, Hasan Agin, Pinar Hepduman, Emine Akkuzu, Tanil Kendirli, Hasan Ozen, Sevgi Topal, Çağlar Ödek, Murat Ozkale, Yasemin Ozkale, Gürkan Atay, Seher Erdoğan, Capan Konca, Guler Yapici, Gazi Arslan, Tolga Besci, Resul Yilmaz, Meltem Gumus, Arzu Oto, Tahir Dalkiran, Mehmet Mercan, Yasemin Çoban, Sevcan Ipek, Sukru Gungor, Ali Ertug Arslankoylu, Mehmet Alakaya, Ferhat Sari, Aylin Yucel, and Abdullah Yazar
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calorie intake ,malnutrition ,nutrition ,pediatric intensive care unit ,protein intake ,Pediatrics ,RJ1-570 - Abstract
IntroductionMalnutrition is defined as a pathological condition arising from deficient or imbalanced intake of nutritional elements. Factors such as increasing metabolic demands during the disease course in the hospitalized patients and inadequate calorie intake increase the risk of malnutrition. The aim of the present study is to evaluate nutritional status of patients admitted to pediatric intensive care units (PICU) in Turkey, examine the effect of nutrition on the treatment process and draw attention to the need for regulating nutritional support of patients while continuing existing therapies.Material and MethodIn this prospective multicenter study, the data was collected over a period of one month from PICUs participating in the PICU Nutrition Study Group in Turkey. Anthropometric data of the patients, calorie intake, 90-day mortality, need for mechanical ventilation, length of hospital stay and length of stay in intensive care unit were recorded and the relationship between these parameters was examined.ResultsOf the 614 patients included in the study, malnutrition was detected in 45.4% of the patients. Enteral feeding was initiated in 40.6% (n = 249) of the patients at day one upon admission to the intensive care unit. In the first 48 h, 86.82% (n = 533) of the patients achieved the target calorie intake, and 81.65% (n = 307) of the 376 patients remaining in the intensive care unit achieved the target calorie intake at the end of one week. The risk of mortality decreased with increasing upper mid-arm circumference and triceps skin fold thickness Z-score (OR = 0.871/0.894; p = 0.027/0.024). The risk of mortality was 2.723 times higher in patients who did not achieve the target calorie intake at first 48 h (p = 0.006) and the risk was 3.829 times higher in patients who did not achieve the target calorie intake at the end of one week (p = 0.001). The risk of mortality decreased with increasing triceps skin fold thickness Z-score (OR = 0.894; p = 0.024).ConclusionTimely and appropriate nutritional support in critically ill patients favorably affects the clinical course. The results of the present study suggest that mortality rate is higher in patients who fail to achieve the target calorie intake at first 48 h and day seven of admission to the intensive care unit. The risk of mortality decreases with increasing triceps skin fold thickness Z-score.
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- 2023
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11. How Does Respiratory Rate Affect Alveolar Ventilation in Pediatric Patients?
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Gokhan Ceylan, Gülhan Atakul, Sevgi Topal, Mustafa Çolak, Ekin Soydan, Ferhat Sarı, Pınar Seven, Özlem Saraç Sandal, and Hasan Ağın
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alveolar ventilation ,dead space ,respiratory rate ,minute ventilation ,mecahnical ventilation ,pediatric intensive care unit ,Pediatrics ,RJ1-570 - Abstract
Objective: Minute ventilation is a combination of alveolar ventilation (V'alv) and dead space ventilation which is also a result of multiplication of respiratory rate (RR) by tidal volume. V'alv is the volume of the air which reaches the alveoli per minute by definition. The aim of this study was to examine the effect of RR on V'alv in a pediatric physiologic bench setting. Method: In our study, respiratory parameters of a male child, approximately 1 year old, 78 cm in length and ideal body weight of 10 kg, were simulated. This model was ventilated in two different RR settings and with two different breathing circuits which has different dead space (DS) values. However amount of CO2 was kept same during whole bench. Static compliance, static resistance, end-tidal-carbondioxide, positive end expiratory pressure, peak inspiratory pressure, inspiratory time, expiratory-time values of each breathing circuit were taken as the mean and standard deviation of repeated measurements. Results: V'Alv decreased from 1.84+-0.3 L/m to 1.63+-0.5 L/m (p
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- 2022
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12. Central Venous Catheter Types and Association with Bloodstream Infection in the Pediatric Intensive Care Unit: Experience of two Years
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Sevgi Topal, Özlem Saraç Sandal, Gökhan Ceylan, Gülhan Atakul, Mustafa Çolak, Ekin Soydan, Utku Karaarslan, Elif Boncuoğlu, İlker Devrim, and Hasan Ağın
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catheter-associated bloodstream infections ,central venous catheter ,pediatric intensive care unit ,Pediatrics ,RJ1-570 - Abstract
Objective: Central venous catheters (CVC) provides great convenience in pediatric intensive care units (PICUs). In this study, we aimed to prospectively examine patients who underwent CVC in the PICU in terms of catheter types and infections Methods: We conducted our monocentric, prospective, and cohort study by including patients between January 2019 and December 2020, involving all central catheters temporarily inserted, except port-line catheters, PICCs, indwelling catheters (cuffed and uncuffed tunnel catheters), and arterial catheters. The main issue we focus on is the rate of catheter-associated bloodstream infection (CLABSI). We analyzed the relationship between infection and risk factors using binary logistic regression analysis. Results: We included 26 CLABSIs with 196 CVCs. The incidence rate was 6.2/1000 catheter days. We found that the incidence of CLABSI increased in femoral catheters (OR: 0.04 p: 0.035, 95% CI: 0.49-3.49). Moreover, the incidence was increased in catheters with 3 lumens (OR: 0.06, p: 0.031, 95% CI: 0.34-1.69). The prolongation of the catheter also increases the risk of infection (OR: 0.06, p: 0.028, 95% CI: 0.56-2.36). Also, we found that the frequency of CLABSI increased in patients with underlying immunodeficiency (OR: 0.19, p: 0.007, 95% CI: 0.85-1.39) and in patients who were given total parenteral nutrition (OR: 0.02, p: 0.041, 95% CI: 0.063-2.38). Conclusion: The number of studies that directly compare catheter types in pediatric patients and their relationship with CLABSI is limited. Moreover, the comparison of unrelated studies is difficult because of heterogeneity in study populations. Multicenter pediatric prospective studies focused on identifying catheter-associated infections are needed.
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- 2021
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13. TOPLUMSAL CİNSİYET EŞİTSİZLİĞİ BAĞLAMINDA KADIN YOKSULLUĞU VE SÜRDÜRÜLEBİLİR KALKINMA: TÜRKİYE ÖLÇEĞİNDE BİR İNCELEME
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Sevgi TOKGÖZ GÜNEŞ and Gül BİNBOĞA
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sürdürülebilir kalkınma ,yoksulluk ,kadın yoksulluğu ,cinsiyet eşitsizliği ,türkiye ,sustainable development ,poverty ,women’s poverty ,gender inequality ,turkey ,Social sciences (General) ,H1-99 - Abstract
ÖZ: Dünya ekonomilerinde yükselen eşitsizliklerin ve krizlerin temelinde sürdürülebilir olmayan üretim ve tüketim modelinin yer aldığı artık kabul edilen bir gerçektir. Bu noktada sürdürülebilir kalkınma; bugünün ihtiyaçlarını karşılarken gelecek nesillerin ihtiyaçlarını karşılayabilme yeteneğini tehlikeye atmayan, sadece nicel bir büyümeyi değil çevre ve sosyal sürdürülebilirliği gözeten bir model olarak ülkelerce benimsenmeye başlanmıştır. Hiç kimseyi geride bırakmamak sloganıyla Birleşmiş Milletlerce deklare edilen 2030 yılı sürdürülebilir kalkınma amaçlarından ikisi; yetersiz beslenmeden sosyal dışlanma ve kararlara katılamamaya değin çeşitli şekillerde tezahür eden yoksulluğun sona erdirilmesi ve toplumsal cinsiyet eşitliğinin sağlanmasıdır. Yoksulluğu deneyimleyen spesifik gruplardan birisi de toplumda bulunduğu dezavantajlı pozisyonuyla kadınlardır. Sürdürülebilir gelişmenin sağlanmasında, toplumun yarısını oluşturan kadın nüfusunun sahip olduğu bilgisini, emeğini, duyarlılığını ve yaratıcı gücünü yaşama aktarabilmesi için toplumsal cinsiyet eşitsizliğinin ve kadın yoksulluğunun giderilmesi kritik önemdedir. Türkiye özelinde toplumsal cinsiyet eşitsizliğinin yarattığı kadın yoksulluğunun sürdürülebilir kalkınma ekseninde incelendiği bu çalışmada; eğitime erişim, işgücüne katılım ve parlamentoda temsil oranları açısından kadınların dezavantajlı durumlarında yeterli düzeyde bir iyileşmeye ulaşılamadığı sonucu elde edilmiştir. Bu kapsamda, sürdürülebilir kalkınma politikalarının daha yoğun bir şekilde uygulanmaya başladığı 1999 yılından itibaren toplumsal cinsiyet eşitsizliği dolayısıyla kadın yoksulluğunun giderilmesi amacıyla atılan adımların ekonomi ve kamu politikalarındaki düzenlemelerle daha üst bir boyuta taşınması gerektiği söylenebilir. ABSTRACT: It is an accepted reality that an unsustainable production and consumption model is at the root of rising inequalities and crises in world economies. At this point, sustainable development has started to be adopted by countries as a model that does not compromise the ability to meet the needs of future generations' while at the same time fulfilling the needs of our day, that takes not only the quantitative growth but also environmental and social sustainability into account. Two of the goals for sustainable development declared by the United Nations for the year 2030 with the slogan of leaving no one behind are to end poverty manifesting itself in various ways from malnutrition to social ostracism and inability to participate in decisions and to actualize gender equality. One of the specific groups experiencing poverty is women with their disadvantageous position in society. It is of critical importance to eliminate gender inequality and women's poverty in order to transfer the knowledge, labor, sensitivity and creative power of the women's population, which makes up half of the society, into life to ensure sustainable development. In this study, women's poverty created by gender inequality in Turkey is examined on the bases of sustainable development. It has been concluded that a sufficient level of improvement has not been achieved in the disadvantaged situations of women in terms of access to education, labor force participation and representation in parliament. In this context, it can be said that the steps taken to eliminate women's poverty due to gender inequality since 1999, when sustainable development policies began to be implemented more intensively, should be carried to a higher level with regulations in economy and public policies.
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- 2021
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14. Closed–loop oxygen control improves oxygenation in pediatric patients under high–flow nasal oxygen—A randomized crossover study
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Ozlem Sandal, Gokhan Ceylan, Sevgi Topal, Pinar Hepduman, Mustafa Colak, Dominik Novotni, Ekin Soydan, Utku Karaarslan, Gulhan Atakul, Marcus J. Schultz, and Hasan Ağın
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intensive care ,pediatric [MeSH] ,hypoxemia ,oxygen therapy ,high flow (NHF) ,automation ,Medicine (General) ,R5-920 - Abstract
BackgroundWe assessed the effect of a closed–loop oxygen control system in pediatric patients receiving high–flow nasal oxygen therapy (HFNO).MethodsA multicentre, single–blinded, randomized, and cross–over study. Patients aged between 1 month and 18 years of age receiving HFNO for acute hypoxemic respiratory failure (AHRF) were randomly assigned to start with a 2–h period of closed–loop oxygen control or a 2–h period of manual oxygen titrations, after which the patient switched to the alternative therapy. The endpoints were the percentage of time spent in predefined SpO2 ranges (primary), FiO2, SpO2/FiO2, and the number of manual adjustments.FindingsWe included 23 patients, aged a median of 18 (3–26) months. Patients spent more time in a predefined optimal SpO2 range when the closed–loop oxygen controller was activated compared to manual oxygen titrations [91⋅3% (IQR 78⋅4–95⋅1%) vs. 63⋅0% (IQR 44⋅4–70⋅7%)], mean difference [28⋅2% (95%–CI 20⋅6–37⋅8%); P < 0.001]. Median FiO2 was lower [33⋅3% (IQR 26⋅6–44⋅6%) vs. 42⋅6% (IQR 33⋅6–49⋅9%); P = 0.07], but median SpO2/FiO2 was higher [289 (IQR 207–348) vs. 194 (IQR 98–317); P = 0.023] with closed–loop oxygen control. The median number of manual adjustments was lower with closed–loop oxygen control [0⋅0 (IQR 0⋅0–0⋅0) vs. 0⋅5 (IQR 0⋅0–1⋅0); P < 0.001].ConclusionClosed-loop oxygen control improves oxygenation therapy in pediatric patients receiving HFNO for AHRF and potentially leads to more efficient oxygen use. It reduces the number of manual adjustments, which may translate into decreased workloads of healthcare providers.Clinical trial registration[www.ClinicalTrials.gov], identifier [NCT 05032365].
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- 2022
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15. HPLC fluorescence method for the determination of nizatidine in human plasma and its application to pharmacokinetic study
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Mahmut B, Çakar and Sevgi T, Ulu
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Histamine H2 Antagonists ,Humans ,Chromatography, High Pressure Liquid ,Fluorescence ,Nizatidine - Abstract
A sensitive high-performance liquid chromatographic (HPLC) method was developed for the determination of nizatidine in human plasma. Nizatidine was derivatized by 4-fluoro-7-nitrobenzofurazan (NBD-F). Chromatographic separation was performed on a Inertsil C18 column (150 mm × 4.6 mm, 5 µm) using isocratic elution by a mobile phase consisting of methanol/water (55:45) at a flow rate of 1.2 mL/min. Amlodipine was used as the internal standard (IS). Fluorescence detector was used operated at 461 nm (excitation) and 517 nm (emission), respectively. The calibration curve was linear over the range of 50-2000 ng/mL. This method was successfully applied to a pharmacokinetic study after oral administration of a dose (150 mg) of nizatidine.
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- 2013
16. Automated closed–loop FiO2 titration increases the percentage of time spent in optimal zones of oxygen saturation in pediatric patients–A randomized crossover clinical trial
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Ekin Soydan, Gokhan Ceylan, Sevgi Topal, Pinar Hepduman, Gulhan Atakul, Mustafa Colak, Ozlem Sandal, Ferhat Sari, Utku Karaarslan, Dominik Novotni, Marcus J. Schultz, and Hasan Agin
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intensive care ,pediatric intensive care ,mechanical ventilation ,Adaptive support ventilation ,ASV ,closed loop ventilation ,Medicine (General) ,R5-920 - Abstract
IntroductionWe aimed to compare automated ventilation with closed–loop control of the fraction of inspired oxygen (FiO2) to automated ventilation with manual titrations of the FiO2 with respect to time spent in predefined pulse oximetry (SpO2) zones in pediatric critically ill patients.MethodsThis was a randomized crossover clinical trial comparing Adaptive Support Ventilation (ASV) 1.1 with use of a closed–loop FiO2 system vs. ASV 1.1 with manual FiO2 titrations. The primary endpoint was the percentage of time spent in optimal SpO2 zones. Secondary endpoints included the percentage of time spent in acceptable, suboptimal and unacceptable SpO2 zones, and the total number of FiO2 changes per patient.ResultsWe included 30 children with a median age of 21 (11–48) months; 12 (40%) children had pediatric ARDS. The percentage of time spent in optimal SpO2 zones increased with use of the closed–loop FiO2 controller vs. manual oxygen control [96.1 (93.7–98.6) vs. 78.4 (51.3–94.8); P < 0.001]. The percentage of time spent in acceptable, suboptimal and unacceptable zones decreased. Findings were similar with the use of closed-loop FiO2 controller compared to manual titration in patients with ARDS [95.9 (81.6–98.8) vs. 78 (49.5–94.8) %; P = 0.027]. The total number of closed-loop FiO2 changes per patient was 52 (11.8–67), vs. the number of manual changes 1 (0–2), (P < 0.001).ConclusionIn this randomized crossover trial in pediatric critically ill patients under invasive ventilation with ASV, use of a closed–loop control of FiO2 titration increased the percentage of time spent within in optimal SpO2 zones, and increased the total number of FiO2 changes per patient.Clinical trial registrationClinicalTrials.gov, identifier: NCT04568642.
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- 2022
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17. Evaluation of Inhaled Nitric Oxide Use in Patients with Pediatric Acute Respiratory Distress Syndrome
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Gülhan Atakul, Gokhan Ceylan, Ferhat Sarı, Özlem Sarac Sandal, Sevgi Topal, Mustafa Çolak, Utku Karaarslan, and Hasan Agin
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pediatric acute respiratory distress syndrome ,inhale nitric oxide ,pediatric intensive care unit ,Pediatrics ,RJ1-570 - Abstract
Objective: Nitric oxide therapy is not routinely used in the treatment of pediatric acute respiratory distress syndrome (PARDS), but it is recommended to be used as an adjunctive therapy in some selected cases. In our study, we aimed to discuss patients with PARDS who were treated with inhaled nitric oxide (iNO) therapy. Methods: The data of patients who were hospitalized in the pediatric intensive care unit with a diagnosis of PARDS and received iNO treatment between January 2016 and January 2018 were retrospectively analyzed. Age, gender, length of stay, mortality, number of days on mechanical ventilation, use of vasoactive drugs, mortality scores, lactate levels, OI (oxygenation index), PaO2/FiO2, methemoglobin levels, iNO administration time, echocardiographic findings and underlying primary diseases were recorded. Results: It was determined that 9 patients who were followed up with the diagnosis of PARDS were given iNO treatment. Except for one patient, they were diagnosed with pneumonia developing on the basis of chronic disease and PARDS secondary to septic shock. Five patients died while receiving iNO therapy. Seven patients were ventilated with iNO in addition to conventional mechanical ventilation methods. Two patients who died were ventilated with HFOV (high frequency oscillatory ventilation). In 3 of 9 patients, inhaled nitric oxide treatment was successful. Conclusion: Although inhaled nitric oxide treatment is a known treatment used in different diseases, the level of its effect in PARDS patients continues to be investigated. We think that this treatment can be beneficial when applied in selected patients and experienced centers.
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- 2021
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18. Do Intratumoral And Peritumoral Apparent Diffusion Coefficient (ADC) Values Have A Role In The Diagnosis Of Pediatric Brain Tumors?
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Güleç Mert Doğan, Ahmet Sığırcı, Sevgi Taşolar, Aslınur Cengiz, Hilal Er Ulubaba, Selami Çagatay Önal, and Neşe Karadağ
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apparent diffusion coefficient ,brain tumor ,magnetic resonance image ,Pediatrics ,RJ1-570 - Abstract
INTRODUCTION: The motion of water particles within biological tissues, which is called random Brownian motion, is detected at the microscopic level by Diffusion-Weighted Imaging (DWI) sequence of Magnetic Resonance Image technique. The Apparent Diffusion Coefficient (ADC) calculated on DWI has been used for tumor diagnosis and grading. The purpose of this study was to evaluate of ADC values in the differential diagnosis of supratentorial and infratentorial pediatric brain tumors and to reveal the difference of peritumoral ADC measurements of pediatric patients from adult patients. METHODS: All of the 56 pediatric patients included in this retrospective study had lesions >1 cm in diameter on magnetic resonance image and all of the diagnosies were confirmed by histopathology. Intratumoral and peritumoral ADC values and ratios were measured in diffusion weighted Magnetic Resonance Image. RESULTS: The 58.9% (n=33) of these tumors were supratentorial and 41.1% (n=23) were infratentorial. ADC values and ADC ratios were significantly lower in high-grade tumors than low-grade tumors (p
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- 2020
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19. Farklı düzeylerdeki tıp fakültesi öğrencilerinin öğrenme yaklaşımı tercihleri
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Sevgi Turan, Dilek İlhan Beyaztaş, Arif Onan, and Melih Elçi̇n
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learning approaches ,medical students ,learning preferences ,learning skills ,medical education ,öğrenme yaklaşımları ,tıp öğrencisi ,öğrenme tercihleri ,öğrenme becerileri ,tıp eğitimi ,Medicine (General) ,R5-920 - Abstract
Amaç: Tıp öğrencilerinin öğrenmelerini desteklemek için - öğrenmelerinin gerçekleşme şekli - öğrenme sürecinin kalitesi ve gelişiminin daha iyi anlaşılması gerekmektedir. Bu araştırma tıp fakültesi öğrencileri tarafından tercih edilen öğrenme yaklaşımlarını ve zaman içinde meydana gelen değişiklikleri belirlemeyi amaçlamaktadır.Gereç ve Yöntem: İzlem çalışması dahil olmak üzere kesitsel bir çalışma yapılmıştır. Çalışma grubunu 2011-2015 yılları arasında Hacettepe Üniversitesi Tıp Fakültesi'ne kayıtlı birinci sınıf öğrencileri (n = 2714) oluşturmaktadır. İzlem çalışması Mayıs 2016'da 1195 öğrenci katılımıyla gerçekleştirilmiştir. Araştırmada Öğrenme Yaklaşımları ve Çalışma Becerileri Ölçeği” kullanılmıştır. Çalışmada öğrencilerin yıllar içinde tercih ettikleri öğrenme yaklaşımlarındaki değişiklikleri incelemek amacıyla ilk yıl öğrenme yaklaşımlarının puanları karşılaştırılmıştır. Ek olarak öğrencilerin ilk ve ikinci puanları da karşılaştırılmıştır.Bulgular: Çalışmaya katılım oranı %80'dir. Çalışma ASSIST ölçeğini iki kez yanıtlayan öğrencilerin oranı (n = 1195) ise %55'dir. 2011-2014 yılları arasında öğrencilerin öğrenme yaklaşımları puanları sırasıyla stratejik, derin ve yüzeysel öğrenme yaklaşımları olarak sıralanmıştır. Bununla birlikte, 2015 yılı kohort puanları derin, stratejik ve yüzeysel öğrenme olarak sıralanmıştır. Tıp öğrencileri ilk yıl stratejik öğrenme yaklaşımını tercih ettikleri görülmektedir. İkinci değerlendirmede tercihleri farklılaşmaktadır. Yüzeysel öğrenme puanları ilk değerlendirmeye göre artmıştır.Sonuç: Öğrencilerin öğrenme becerileri sadece ilk yıl değil, tüm öğretim süresi boyunca desteklenmelidir. İkinci değerlendirmede öğrencilerin stratejik ve derin öğrenme puanları azalırken, yüzeysel öğrenme yaklaşımının ortalama puanı toplamda artmıştır.
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- 2020
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20. HPLC fluorescence method for the determination of nizatidine in human plasma and its application to pharmacokinetic study
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Çakar, Mahmut B., primary and Ulu, Sevgi T., additional
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- 2013
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21. Firuz Kazımzade, Transkafkasya İçin Mücadele (1917-1921), Çeviren: Cengiz İ. Çay, İstanbul, Tarih ve Kuram Yayınları, 2016, 416 s.
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Sevgi Tuhan Aydın
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History (General) and history of Europe ,Political science (General) ,JA1-92 - Published
- 2019
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22. Otologic Findings Based on no Complaints in a Pediatric Examination
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Emine Demir, Sevgi Topal, Gorkem Atsal, Mehmet Erdil, Zerrin Ozergin Coskun, and Engin Dursun
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otoscopy ,pediatrics ,otologic ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Abstract Introduction the otological evaluation is highly significant in those branches of medicine in which the general evaluation of the patient is conducted by general practitioners and pediatricians. Objectives To investigate the otologic findings and their incidences in the sample, which consisted of patients who presented to the pediatric outpatient clinic with non-otologic complaints. Methods Patients, aged between 2 and 16 years, who had neither otorhinolaryngological complaints nor history of surgery by the otolaryngology (ear, nose and throat, ENT) department were included in the present study. The findings detected in the external auditory system and in the tympanic membranes as well as the otorhinolaryngologists' otologic examination findings of the referred patients were recorded from the files of each patient along with the applied medical and surgical treatments, and diagnostic investigations. Results Of a total of 973 patients evaluated, 129 (13.2%) were referred to the ENT outpatient clinic due to any otologic pathology. In the otorhinolaryngological examinations, false positivity was detected in 12 (1.2%) patients, and pathological findings were detected in 117 (12%) patients who received the following diagnoses: 68 (6.9%) had otitis media with effusion(OME); 37 (3.8%) had cerumen impactions; 8 (0.8%) had acute otitis media (AOM); 2 (0.2%) had ticks in the external auditory canal; 2 (0.2%) had a retraction pocket in tympanic membrane; 1 (0.1%) had unilateral central dry perforation of the tympanic membrane; and 1(0.1%) had congenital cholesteatoma. Conclusion Any complications and sequelae that may develop due to any pathologies and predominantly infections can be prevented by an early diagnosis, which can be made by means of a simple examination, performed merely with an otoscope. Pediatricians and general practitioners should be in close contact with otorhinolaryngologists regarding the pathologies they identify.
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- 2019
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23. Early postoperative capsular block syndrome
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Durak, Idot;smet, primary, Özbek, Zeynep, additional, Ferliel, Sevgi T, additional, Öner, Hakan F., additional, and Söylev, Meltem, additional
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- 2001
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24. HPLC fluorescence method for the determination of nizatidine in human plasma and its application to pharmacokinetic study.
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Çakar, Mahmut B. and Ulu, Sevgi T.
- Abstract
ABSTRACT A sensitive high-performance liquid chromatographic (HPLC) method was developed for the determination of nizatidine in human plasma. Nizatidine was derivatized by 4-fluoro-7-nitrobenzofurazan (NBD-F). Chromatographic separation was performed on a Inertsil C
18 column (150 mm × 4.6 mm, 5 µm) using isocratic elution by a mobile phase consisting of methanol/water (55:45) at a flow rate of 1.2 mL/min. Amlodipine was used as the internal standard (IS). Fluorescence detector was used operated at 461 nm (excitation) and 517 nm (emission), respectively. The calibration curve was linear over the range of 50-2000 ng/mL. This method was successfully applied to a pharmacokinetic study after oral administration of a dose (150 mg) of nizatidine. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2014
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25. Pre-Descemet’s membrane hemorrhage after secondary intraocular lens implantation
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Durak, İsmet, primary, Ferliel, Sevgi T, additional, Söylev, Meltem, additional, and Saatçi, Osman, additional
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- 1999
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26. Expanding the spectrum of SMAD3‐related phenotypes to agnathia‐otocephaly
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Nicole Meier, Elisabeth Bruder, Peter Miny, Sevgi Tercanli, and Isabel Filges
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agnathia‐otocephaly ,exome sequencing ,prenatal ,SMAD3 ,Genetics ,QH426-470 - Abstract
Abstract Background Agnathia‐otocephaly is a rare and lethal anomaly affecting craniofacial structures derived from the first pharyngeal arch. It is characterized by agnathia, microstomia, aglossia, and abnormally positioned auricles with or without associated anomalies. Variants affecting function of OTX2 and PRRX1, which together regulate the neural crest cells and the patterning of the first pharyngeal arch as well as skeletal and limb development, were identified to be causal for the anomaly in a few patients. Methods Family‐based exome sequencing (ES) on a fetus with severe agnathia‐otocephaly, cheilognathopalatoschisis, laryngeal hypoplasia, fused lung lobes and other organ abnormalities and mRNA expression analysis were performed. Results Exome sequencing detected a de novo SMAD3 missense variant in exon 6 (c.860G>A) associated with decreased mRNA expression. Variants in SMAD3 cause Loeys–Dietz syndrome 3 presenting with craniofacial anomalies such as mandibular hypoplasia, micro‐ or retro‐gnathia, bifid uvula and cleft palate as well as skeletal anomalies and arterial tortuosity. The SMAD3 protein acts as a transcriptional regulator in the transforming growth factor β (TGFB) and bone morphogenetic (BMP) signaling pathways, which play a key role in the development of craniofacial structures originating from the pharyngeal arches. Conclusion Agnathia‐otocephaly with or without associated anomalies may represent the severe end of a phenotypic spectrum related to variants in genes in the interacting SMAD/TGFB/BMP/SHH/FGF developmental pathways.
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- 2020
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27. EPANET ile hidrolik simülasyon yoluyla bir su dağıtım şebekesinin işletiminin enerji verimliliği açısından iyileştirilmesi
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Hasan Sarptaş, Sevgi Tokgöz Güneş, and Davut Özdağlar
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water distribution network ,pump ,pressure ,operation ,epanet ,energy efficiency ,su dağıtım şebekesi ,pompa ,basınç ,i̇şletim ,enerji verimliliği ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Su dağıtım şebekeleri, genellikle, şebekede basınç açısından en kritik noktalarda yeterli basınç olacak şekilde işletilir. Ancak günün saatleri içindeki debi salınımlarına uyacak ve enerji tüketimini en aza indirecek bir işletme tipi yerine, işletme kolaylığı için, genellikle, basınçların en düşük basıncın oldukça üstünde olduğu düşük basınç şikayetlerine göre bir işletim uygulanmaktadır. Su dağıtım sistemlerinde, zaman, tüketilen su miktarı ve basınç gibi parametreler dikkate alınarak şebeke işletiminin iyileştirilmesi, hem sistemde su kayıplarının önlenmesi hem de enerji verimliliğinin arttırılmasını sağlar. Yerel yönetimler için önemli bir maliyet kalemi olan içmesuyu dağıtım sistemlerindeki enerji tüketimi şebekenin optimum işletimi ile önemli miktarda azaltılarak enerji tasarrufu sağlanabilmektedir. Bu çalışmada, bir organize sanayi bölgesinin su dağıtım şebekesi örnek şebeke olarak ele alınmıştır. Örnek şebekede, su tüketim farklılıkları esas alınarak üç ayrı işletme bölgesi oluşturulmuştur. Bu bölgelerde minimum ve maksimum su tüketimlerinin debi için ekstrem koşullar olduğu kabul edilerek iki ayrı tüketim değeri ve üç işletme için sekiz farklı hidrolik durum oluşturulmuştur. Bu durumlarda oluşan hidrolik koşullar EPANET yazılımı ile simülasyon yoluyla çözümlenmiştir. İşletmede yapılacak iyileştirmelerle elde edilecek enerji tasarrufunu belirleyebilmek için örnek şebekede iki farklı işletme prosedürü tanımlanmıştır: (i) normal (basit) işletme ve (ii) iyileştirilmiş işletme. Çalışma sonunda, iyileştirilmiş işletmenin toplam enerji tüketimini %16 oranında azalttığı hesaplanmıştır. Birim enerji tüketimi normal işletme için 0.314 kWh/m³ değerinden iyileştirilmiş işletme için 0.261 kWh/m³ değerine düşmüştür. Bu çalışma, su dağıtım şebekeleri işletiminin su tasarrufu ve enerji verimliliği açısından iyileştirilmesine ilişkin planlanma çalışmalarında, hidrolik simülasyon yazılımı EPANET’in etkin bir araç olarak kullanılabileceğini ortaya koymaktadır.
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- 2017
28. To Determine The Performance of Family Physicians Working In A District Of Tekirdağ Using Data Envelopment Analysis
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Sevgi TAŞLIDERE, Gamze Varol SARAÇOĞLU, and Birol TOPÇU
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data envelopment analysis (dea) ,family physician ,performance ,health serv ,Medicine - Abstract
Aim:In our country, the 2000s was a period in which implementations of reform in the health field were brought to the agenda. The Health Transformation Program (HTP) developed in this process has firstly necessitated changes in the presentation of primary health care services. As a first for primary health care, family physicians (FP) were adopted, and there was an attempt to offer a personalized preventive and curative health service in this way. Performance evaluations of family physicians in the presentation of health care services are an assessment which has been spoken about quite frequently in the recent period and also overrated by the Ministry of Health.Material and Methods:Due to the importance and necessity of the subject this study proposed to determine the performance of family physicians working in a district of Tekirdağ using Data Envelopment Analysis (DEA) for the determination of areas of disruption and the development of recommendations for a development system in the health services provided by family physicians.Results:Nine FPs are working in the district but there is a lack of a physician in the roaming service area. Data were presented it did not contribute to the calculation of DEA. In the region, 8 of the FPs’ performance were 100%. In terms of accessible resources, it is observed that FP performance can change depending on geography, the population of urban and rural settlements, age, ethnic group and sociodemographic characteristics such as education. The population of the region where the study was carried out has a homogenous, limited and closed geography affected by similar demographic dynamics to a similar degree.Conclusion:In this area, family physicians have a population of similar characteristics. Hundred percent of the available performance may be associated with the reasons stated above. More large-scale analysis should be performed so that the whole province is evaluated or a few districts are evaluated with each other in order to achieve more accurate results.
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- 2017
29. Kur’an’da Erẕeli'l-ʽumur ve Yaşlılık Üzerine Bir Değerlendirme
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Sevgi Tütün
- Subjects
senescence in the qurʾān ,old ,sheikh ,shayb ,dementia ,ardhal al-ʿumur ,kur’an’da yaşlılık ,yaşlı ,erẕeli’l-ʽumur ,şeyḫ ,şeyb ,bunama ,Islam. Bahai Faith. Theosophy, etc. ,BP1-610 - Abstract
İnsan dünyaya geldiği andan itibaren birçok yaşam devresinden geçmektedir. Bebeklikte hatta anne karnında başlayan bu devreler yaşlılık ve ömrün son dönemlerine kadar uzayan bir süreci de beraberinde getirmektedir. Kur'an'da insanın yaratılışından ve hayatının çeşitli dönemlerinden söz edilmekle birlikte yaşlanmaya da atıflar yapılmaktadır. Yaşlılığa işaret eden şeyḫ, şeyb, ʽacûz ve kiber tabirlerinin yanı sıra erẕeli’l-ʽumur da bu konuda Kur’an’da dikkatleri çekmektedir. Makalemiz erzeli'l-ʽumur ve yaşlılık ile ilgili lafızların Kur’an bünyesinde hangi bağlamlarda ve anlamlarda yer aldığını tespit etmeyi ve bu kavramlar arasındaki ilişkiyi ortaya koymayı hedeflemektedir. Çünkü tefsirlerde çoğunlukla erẕeli’l-ʽumur kavramı ile yaşlılıkta bunama arasında doğrudan bir bağlantı kurulmakta ve yorumlar adeta bu iki tabirin eşanlamlı olduğu algısını oluşturmaktadır. Gerçekten erẕeli’l-ʽumur ve bunama birebir örtüşmekte midir? Ayrıca Kur’an’da geçen ve yaşlılığa işaret eden diğer kavramlar ile bunama arasında bir bağlantı kurulmakta mıdır? Çalışmamızda Kur'an'da geçen erzeli'l-ʽumur tabirinin bu bağlamda açıklanması amaçlanmaktadır. Bununla beraber Kur’an’da yaşlılık hakkında kullanılan diğer kavramlar da bu açıdan gözden geçirilmektedir. Kur’an’da insanın yaratılışı anlatıldığı gibi onun yaşamının değişik kısımlarına da yer verilmekte, yaratılış ile başlayan açıklamalar insanın doğum öncesini, bebeklik ve çocukluğunu, gençlik ve yetişkinliğini anlatmaktadır. Kur’an’da yaşam dönemlerinin en sonuncusu olan yaşlılığa da değinilmektedir. Bu bağlamda erzeli’l-ʽumur, şeyḫ, şeyb, ʽacûz ve kiber Kur’an’da kullanılan yaşlılık bağlantılı tabirlerdir. Yaşlılık Kur’an’da bahsedilmesinin yanı sıra özellikle günümüzde bilimsel anlamda üzerinde oldukça durulan bir konudur. Makalemizde konu bilimsel olarak da ele alınmıştır. Yaşlılık fiziksel, psikolojik ve sosyal boyutları olan bir dönemi ifade ettiğinden çeşitli açılardan ele alınarak tanımlanmaktadır. Ayrıca yaşlılık ile ilgili bir takım sınıflandırmalar yapılmakta ve bu konuda daha çok kronolojik yaşa bağlı fizyolojik değişimler vurgulanmaktadır. Yaşlanmanın biyolojik ve kronolojik olmak üzere ikiye ayrıldığı da belirtilmiştir. Buna göre kronolojik yaş herkes için aynı olmakla beraber biyolojik yaş kişiden kişiye değişim göstermektedir. Sosyal bilimler açısından ise yaşlılık insan hayatının son gelişim basamağı kabul edilmekte, yaşlanma doğum ile ölüm arasında devam etmekte olan evrensel bir süreç olarak görülmektedir. Bu nedenle yaşlılık göreceli fakat yaşlanma evrensel olarak değerlendirilmektedir. Böylece herkesin yaşlanması söz konusu olmakla birlikte yaşlılık kişiye göre değişen bir hayat dönemini dile getirmektedir. Yaşlılık sağlığı etkilediği gibi, psikolojik, sosyolojik ve ekonomik düzeyde de bireyi etkilemektedir. Başka bir ifadeyle zor bir süreç olan yaşlılık insanı var kılan bütün özelliklerini derinden etkileyen bir olgudur. Yaşlılık Kur’an’da çeşitli tabirlerle ele alınmaktadır. Bunların başında gelen erzeli'l-ʽumur Kur'an’da iki yerde geçmektedir. (en-Nahl 16/70- el-Hac 22/5) Müfessirler genellikle erzeli’l-ʽumuru yaşlılıktan dolayı kişinin fizyolojik olarak yıpranması ve bunamanın gerçekleştiği dönem olarak düşünmüşlerdir. Kur'an'da erzeli'l-ʽumur olarak adlandırılan dönemin özelliği bilirken hiçbir şey bilmez hâle gelmek ifadesiyle açıklanmaktadır. Zaten erzeli’l-ʽumura bunama anlamının verilmesinin temelinde bu cümle yatmaktadır. Acaba erzeli’l-ʽumur ve bunama birebir örtüşmekte midir? Bu makalede Kur’an’da yaşlılık hakkında kullanılan diğer kavramlar da bu açıdan gözden geçirilmiştir. Kur’an’da yaşlılıkla ilgili olarak kullanılan bir diğer tabir olan şeyḫ dört yerde (Hûd 11/72, Yusuf 12/78, el-Kasas 28/23, el-Mü’min 40/67)geçmekte ve bunlardan ikisinde kebîr kelimesi ile nitelendirilmektedir. Şeyḫ sözlükte görünüş ve yaş itibariyle yaşlı olan kimse anlamına gelmektedir. Bununla beraber örfte ilmi çok olan kişiler hakkında da şeyḫ sıfatı kullanılmaktadır. Böylece şeyḫ kelimesi yaşı ilerlemiş olmakla beraber bilgi ve tecrübe bakımından bir üstünlüğün ifadesi olmaktadır. Kur’an’da yaşlılık için kullanılan bir başka kelime olan şeyb de üç yerde (Meryem 19/4, er-Rûm 30/54, el-Müzzemmil 73/17) geçmekte olup saç ve saçın beyazlığı anlamına gelmekte ve yaşlılıktaki fizyolojik bir değişimi anlatmaktadır. Kur’an’da yaşlılığı ifade etmek için kullanılan ʽacûz, dört ayrı surede (Hûd 11/72, eş-Şuarâ 26/171, es-Saffât 37/135, ez-Zâriyât 51/29) yer almakta ve işlerin birçoğunu yapmadaki acziyeti dile getirmektedir. Kur’an’da acûz, yaşın büyüklüğünü anlatan bir diğer ifadedir. Bu tabir ile de yaşlılık kastedilmekte ancak bir bunamadan bahsedilmemektedir. Yaşlılık ile irtibatlı lafızlardan sonuncusu olan kiber ise Kur’an’da altı ayette (el-Bakara 2/266; Âl-i-İmrân 3/40, İbrâhim 14/39, el-Hicr 15/54, el-İsrâ 17/23, Meryem 19/8) geçmektedir. Kiber kelimesi yaşlılık ve fiziki güç kaybı ifade eden bir anlama sahip olmakla birlikte yine bunama ile ilişkili bir mana içermemektedir. Tefsirlerin birçoğunda yaşlılık ve bunama ile bağlantılı yapılan açıklamalar kanaatimizce Kur’an’da karşılığını bulamamaktadır. Şöyle ki erzeli’l-ʽumur tabiri ile yaşlılıkta bunama eş anlamlı gibi algılanmaktadır. Erzeli’l-ʽumur kelimesinin sözlük anlamı içinde bunamaya işaret eden ifadelerin varlığı böyle bir algıya yol açmış olabilir. Günümüz biliminin ulaştığı veriler ışığında bunamanın yaşlılığın getirdiği tabii bir sonuç olmadığı ancak risklerinden biri olduğu anlaşılmaktadır. Zaten bilimin bunamayı normal yaşlanma sürecinden ayrı ele alması bunu göstermektedir. Dolayısıyla tüm yaşlıları içine alan genel bir bunama tablosu ortaya çıkmamaktadır. Böylece erzeli’l-ʽumuru; bazı yaşlıları içine alan, aklî melekelerde kayıpların yaşandığı ve kişileri fizyolojik, psikolojik, sosyolojik vb. birçok yönden etkileyen ileri hayat dönemi olarak tanımlamak mümkündür. Kur’an’da yaşlılık ile ilgili tabirlerin her biri Kur’an’ın bütünlüğü çerçevesinde bir yaşlılık resmi ortaya çıkarmaktadır. Kur’an’da yaşlılık kaçınılması mümkün olmayan bir realitedir. Ayetlerde bu dönemin açıkça belirtilmesi insanın bu gerçeği kabul etmesine ve o döneme hazırlanmasına yöneliktir. Kur’an’da yaşlıların karşılaşacağı bazı problemlere de değinilmektedir. Kur’an’da yer alan erzeli’l-ʽumur dışındaki yaşlılık ile ilişkili diğer kavramlar incelendiğinde değinilen hususların ileri yaşlardaki kişilerde gözlemlenebilen saç beyazlaması, kemik rahatsızlıkları, birtakım işlerini yapmada yetersizlikler ve güçsüzlükler olduğu görülmektedir. Bugün yaşlılar ile ilgilenen çeşitli bilim dalları vardır ve onların ulaştığı bilgiler bu sorunların Kur’an’da değinilenlerden çok daha fazla olduğunu göstermektedir. Ancak Kur’an ilahi bir kitap olduğundan bir bilim kitabı gibi olgulara yaklaşması beklenemez. Erzeli’l-ʽumur bilimsel veriler ışığında değerlendirildiğinde bazı yaşlıların bunama/şuur kaybı gibi zihinsel anlamda sıkıtılar yaşayacağı bir hastalık dönemi olarak karşımıza çıkmaktadır. Bunu tecrübe edecek yaşlılar olacağı gibi etkilenmeyenler de olacaktır. Kur’an’da geçen yaşlılık ile ilgili tüm tabirler de yaşlanmanın doğrudan tamamen bunamayı getirdiği sonucuna götürmemektedir. Kur’an bütünlüğü içerisinde erzeli’l-ʽumur yaşlılıkta bunamanın bazı kişileri etkilemekle beraber bir kısmını içine almadığını anlatmaktadır. Dolayısıyla erzeli’l-ʽumur her yaşlıyı değil ama bir kısmını etkileyen yaşam dönemlerinden biridir. Kur’an’da yaşlılar ile ilgili farklı kavramların kullanılması da yaşlanma sürecinin değişik etkilere yol açan çeşitli yönlerine dikkat çekmektedir. Kur’an’da yaşlanmadan bahsedilmesinin ikinci önemli sebebi yaşlı insanın taşıdığı değere ve ona gösterilmesi gereken itibara işaret etmektir. Ayrıca yaşlıların psikolojik ve sosyal açıdan tek başlarına bırakılmayacak kadar değerli oldukları da Kur’an’da altı çizilen konulardandır. Zira Kur’an’a göre yaşlılar sevgi ve değere layık bireylerdir. Dolayısıyla Kur’an’da gerek erzeli’l-ʽumurla karşılaşacak olsun gerekse bu dönemle karşılaşmayacak olsun yaşlılara sevgi, saygı ve hürmet gösterip onlarla birlikte bir hayat sürdürülmesi öngörülmektedir. İşte bu yüzden insana yaşlılarına sahip çıkıp onlara maddî-manevî hak ettikleri değeri verme yükümlülüğünde olduğu ve bu dönemin özelliğini dikkate alarak hareket etmesi hatırlatılmaktadır.
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- 2016
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30. Experiments with the Concept of Authenticity in Studio Pedagogy: Designing with Precedents
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Sevgi Türkkan and Arzu Erdem
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architectural education ,authenticity ,creativity ,design tools ,manipulation ,precedent ,studio culture ,studio pedagogy. ,Architecture ,NA1-9428 ,City planning ,HT165.5-169.9 - Abstract
Architectural education, like architectural culture, is charged with responsibility for traditions, rituals, pedagogical models, and norms that place great importance on authenticity. Authenticity, meaning originality or genuineness as well as referring to an individual's creative faculties, is a fundamental concept that distinguishes the designer's capabilities in a creative process. Situated at the core of architectural education, the design studio has long been serving as an environment for the semi-god creator to invent his 'authentic' designs ex-nihilo. The prevalent conception of authenticity is a romanticized one, where unique forms are a means of personal expression and exterior influences are intruders into one's true creativity. Although 'authenticity' was subjected to heavy criticism during the 20th century in various fields, it continues to shape pedagogical tendencies in architectural education today. Taboos on formal similarity, repetition, and ordinariness continue to pressure studio culture. One of the pedagogical implications of this obsession with 'authenticity' is to restrict interaction with precedents in design education. It is worth asking if subverting these taboos on authenticity enhances design studio learning. Is it possible to re-approach precedents as found objects, and manipulation as a tool for alternative modes of creativity and learning in the studio environment? Two design experiments have been devised to rethink authenticity and creation in studio pedagogy, and to experiment with manipulation of precedents as a potential learning and designing resource. It is not intended to neglect or overthrow the concept of 'authenticity' in the design studio, but to reassess it with a critical pedagogical approach that acknowledges architectural qualities other than the purely formal.
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- 2016
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31. FT-IR Spectroscopy Based Evaluation of Changes in Primary Metabolites of Amsonia orientalis after In vitro 6-benzylaminopurine Treatment
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Arda ACEMİ, Sevgi TÜRKER-KAYA, and Fazıl ÖZEN
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Apocynaceae ,in vitro multiplication ,plant growth regulator ,plant primary metabolites ,Forestry ,SD1-669.5 ,Agriculture (General) ,S1-972 - Abstract
Amsonia orientalis Decne. (syn. Rhazya orientalis (Decne.) A. DC.) is only cultivated as an ornamental plant but also has a medicinal merit. The natural populations of the species were taken under conservation as per the Bern Convention by European Council. As one of the most common plant growth regulators and synthetic agricultural fertilizers, the effects of 6-benzylaminopurine (BAP) at different concentrations on primary metabolites of in vitro propagated A. orientalis have been investigated by using Fourier transform infrared (FT-IR) spectroscopy. Among all applied concentrations, 2.0 mg l-1 BAP resulted in increment of hydrogen bonded polysaccharide and proteins concentrations, lipid structure and membrane fluidity. Treatments of 2.0 and 4.0 mg l-1 BAP increased the existence of ferulic acid which also indicates the linkage of xylan and both cellulose and hemicellulose content. There was a significant decrease in the area of the peak which indicated the C=O stretching of proteins and pectins for 0.5 and 1.0 mg l-1 BAP while there was a significant increase for 2.0 and 4.0 mg l-1 of BAP treatments. The evaluation of molecular data from FT-IR spectroscopy as in the current study might help to estimate different physiological changes at the molecular level in plants depending on plant growth regulator and/or fertilizer applications. Thus, this FT-IR based method can be applied to in vitro propagation studies and also to studies focused on effects of pesticide and/or herbicide applications on plants to understand the metabolic changes in target species.
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- 2016
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32. Medical students’ self-efficacy in problem-based learning and its relationship with self-regulated learning
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Meral Demirören, Sevgi Turan, and Derya Öztuna
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self-regulated learning ,problem-based learning ,self-efficacy ,medical students ,medical education ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Background: Problem-based learning (PBL) is most commonly used in medical education to enhance self-regulated learning (SRL) skills. Self-efficacy beliefs affect students’ motivation through self-regulatory processes. The purpose of this study is to examine the relationship between medical students’ self-reported SRL skills and their self-efficacy in PBL. Methods: A cross-sectional study was conducted with second (286; 83.1%) and third (275; 80.2%) year students at the Ankara University School of Medicine. The SRL perception (SRLP) scale and self-efficacy for problem-based learning (SPBL) scale were used in the study. Results: The SRLP subscales were positively correlated with the SPBL subscales. There was a weak but meaningful correlation between the subscales of SRLP (with the exception of the lack of self-directedness scale) and the subscales of SPBL and the students’ views on benefiting from PBL. The female students’ mean score was higher for the ‘planning and goal setting’ subscale of SRLP (p=0.017), and the second-year students’ mean score was higher than that of the third-year students for the ‘lack of self-directedness’ subscale of SRLP (p=0.001) with small effect sizes (Cohen's d is 0.17 and 0.27). There was no statistically significant difference between the year and subscales of SPBL. With regard to gender, the female students had higher scores than the male students on the ‘responsibility’ subscale of SPBL (p=0.003; Cohen's d=0.26). Conclusions: The study showed that medical students used SRL skills and believed in their ability to learn effectively in the PBL context and demonstrated the relationship between SRL skills and self-efficacy beliefs. Monitoring students’ development in these skills and giving them feedback could be beneficial for the cognitive achievement of students with learning difficulties and insufficient study skills. Further studies need to be undertaken to investigate issues such as the curriculum, learning environment, individual differences, and how these can affect the SRL process.
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- 2016
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33. Kur’an’da Bazı İman Konularının Ele Alınışı
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Sevgi Tütün
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Quran ,Faith ,Faithful ,Godless ,Sincerity ,Heart ,Kur'an ,İman ,Mümin ,Kafir ,İhlas ,Kalp ,Philosophy. Psychology. Religion ,Islam. Bahai Faith. Theosophy, etc. ,BP1-610 ,Islam ,BP1-253 - Abstract
Bu makalede Kur'an'ın bazı iman konularını ele alışı üzerinde durulmuştur. Bu bağlamda Kur'an'da imanın insan, kalp, şirk ve ihlas konuları ile bağlantısı incelenmiştir. Ayrıca imanın artması ve iman-psikoloji konularının Kur'an'da ele alınışı değerlendirilmiştir. Kur'an'da imana vurgu yapılan hususlar ve bağlantılar araştırılarak imana yüklenen anlam üzerinde durulmuştur. Böylece Kur'an'da ön görülen iman olgusu açıklanmaya çalışılmıştır.
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- 2015
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34. Visual Event-Related Potentials in Patients with Mild Cognitive Impairment
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Eren Gozke, Sevgi Tomrukcu, and Nursel Erdal
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dementia ,mild cognitive impairment ,visual event-related potentials ,Geriatrics ,RC952-954.6 - Abstract
Background: To compare the findings of visual event-related potential (ERP) in patients with mild cognitive impairment (MCI) and healthy individuals. Methods: Twenty patients (12 males, 8 females) diagnosed as MCI who received no treatment and 20 healthy individuals (14 males, 6 females) with no cognitive impairments were included to the study. To obtain visual ERP responses, 32 (rare) and 64 (frequent) angle checkerboard displays were used. Three channel recordings were performed from Fz, Cz, and Pz. Results: The mean age of the control and MCI groups were 66.0 ± 3.6 and 66.3 ± 4.4 years, respectively. No statistically significant difference was found in the mean age and distribution of gender between the groups. Visual ERP revealed that mean N200 and P300 latencies of the MCI group were significantly longer than controls. The longest N200 and P300 latencies were obtained from Fz. The mean P300 amplitudes were found to be significantly lower in patients with MCI. No significant difference was observed between the two groups with respect to N200 amplitudes. Conclusion: Visual ERP can be used to support MCI diagnosis. Although it is not a diagnostic test for cognitive impairment per se, it is an important, feasible, and noninvasive technique for evaluating the cognitive state.
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- 2016
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35. Development and evaluation of the evidence-based medicine program in surgery: a spiral approach
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Melih Elçin, Sevgi Turan, Orhan Odabaşı, and İskender Sayek
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evidence-based medicine ,spiral curriculum ,medical education ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Background: Evidence-based medicine (EBM) aims to provide skills that help physicians answer clinically important questions, determine new evidence, and incorporate the acquired knowledge in practice. EBM skills are necessary for the practice of modern medicine, since physicians should use up-to-date knowledge and information to justify their medical decisions. Purpose: We aimed to evaluate the EBM program implemented at Hacettepe University School of Medicine. Methods: In 2004, a spiral program for the teaching and practice of EBM was developed for the first 3 years of medical school. Following this program, a practice of EBM was included in the fourth year during the surgery clerkship, after an introductory lecture. The students worked within collaborative teams of 3–5 and practiced EBM with actual cases seen in the surgical service in which they were involved. Each student was asked to complete a questionnaire that evaluated the more theoretical program from the first 3 years and the practical application in the fourth year. Results: Nearly half of the students stated that the preclinical years of the EBM program were ‘adequate’, but only 30% of the students indicated that the program was practical. They stated that ‘more practical approaches were used in the fourth year, whereas more theory-based approaches were used during the preclinical years’. More than 75% of the students declared that the practice of EBM in the fourth year was useful and appropriate for team-based learning. Conclusions: The EBM program was evaluated as ‘adequate’. EBM courses should be included in the entire curriculum in an integrated manner. The students understand the main philosophy of EBM in the clinical year when involved in its practical application with actual patients.
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- 2014
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36. MEI
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Sevgi TÜTÜN
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Qur'an ,exegesis ,period of Ottoman ,Sure el-İhlas ,Hz. Muhammed ,Kur'an ,tefsir ,Osmanlı dönemi ,İhlas SQresi ,Philosophy. Psychology. Religion ,Islam. Bahai Faith. Theosophy, etc. ,BP1-610 ,Islam ,BP1-253 - Abstract
Kur'an-ı Kerim'i anlama faaliyetleri Hz. Muhammed ile birlikte baş lamış ve tarihin her döneminde sürdürülmüştür. Osmanlı döneminde de tefsire dair çalışmalar bu bağlamda devam etmiştir. İhlas suresinin açıklamasını yapan bu risafe ile Osmanlı dönemi tefsirine ışık tutan bir eseri incelemeye çalışacağız. Böylece söz konusu devre ait tefsir özelliklerini bir de bu eser çerçevesinde değerlendirmiş olacağız.
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- 2012
37. Beled Suresi Bağlamında İnsan Ve Özellikleri
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Sevgi Tütün
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Surah al-Balad ,human ,responsibility ,Beled suresi ,insan ,sorumluluk ,Philosophy. Psychology. Religion ,Islam. Bahai Faith. Theosophy, etc. ,BP1-610 ,Islam ,BP1-253 - Abstract
Beled suresi yirmi ayetten oluşan kısa bir sure olmasına rağmen konu açısından oldukça kapsamlıdır. Sure, insanın bazı davranışlarına değinmektedir. Bunlardan bir kısmı onun Allah’a, bir kısmı da topluma karşı sergilediği davranışlarıdır. Beled suresi, aynı zamanda insanın bu dünyada olgunlaşmasını hedeflemektedir. Bu çalışmada Beled suresi bağlamında insanın söz konusu durumu ve sorumluluğu açıklanmakta ve Allah’ın ona sunduğu seçeneklerle biçimlenmektedir. Dolayısıyla Beled suresi, insana bu konuda yol göstermekte ve seçtiği yolun sonuçlarını açıklamaktadır.
- Published
- 2012
38. Yirminci Yüzyıl Müfessirlerinin Garânik Olayına Bakışı
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Sevgi Tütün
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Garânik olayı ,Yirminci Yüzyıl Müfes-sirleri ,Necm Suresi ,Garâniq matter ,Twentieth Century Commen-tators ,Sura al- Necm ,Philosophy. Psychology. Religion ,Islam. Bahai Faith. Theosophy, etc. ,BP1-610 ,Islam ,BP1-253 - Abstract
İslam Tarihi ve Tefsir alanında Garânik olayı üzerinde çeşitli araştırmalar yapılmıştır. Biz bu makalede son dönem müfessirlerinin Garânik meselesine bakışını ortaya koymaya çalıştık. Böylece, Garânik mevzusuna Yirminci Yüzyıl müfessirlerinin yaklaşımını belirlemeye gayret ettik.
- Published
- 2012
39. The Impact of Standardized Patient Feedback on Student Motivational Levels
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Sevgi Turan, Sarp Üner, and Melih Elçin
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Motivation ,learning strategies ,communication skills ,medical students ,standardized patient ,Medicine - Abstract
Objective: The impact of standardized patient feedback on the motivational levels of learners for learning communication skills was examined in the study.Material and Methods: Control group post-test design was used and 284 of Year-I students took part in the study (87%). Both groups were randomly organized. The students had two standardized patient encounters in addition to training and debriefing sessions. The study group students received face-to-face feedback after the first encounters; but not the control group. We used the motivation dimension of Motivated Strategies for Learning Questionnaire and t-test to evaluate the differences between the average scores of motivational levels of both groups for all sub-dimensions.Results: After the first encounters, there is a significant difference between study and control groups in the sub-dimension of test anxiety (p=0.028). After the second encounters, the students of the study group who received feedback after the first encounters, got lower scores in the sub-dimension of test anxiety (p=0.016), and got higher scores in the sub-dimension of self-efficacy (p=0.027).Conclusion: We found out that the students who received feedback had lower levels of test anxiety, and higher levels of self-efficacy. Those results showed that standardized patient feedback eafected student motivational levels in two sub-dimensions.
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- 2011
40. TABERİ TEFSİR’İNDE HZ.AİŞE’NİN RİVAYETLERİ VE TEFSİR METODU
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Sevgi Tütün
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kur’an ,tefsir ,hz. aişe ,rivayet ,taberi tefsiri ,quran ,commentary ,hz. aisah ,narrative ,tefsir of taberi ,History of the arts ,NX440-632 - Abstract
Kur’an’ın anlaşılması ve açıklanması Hz. Peygamber’den itibaren başlamış ve birçok kişi bu konuda faaliyette bulunmuştur. İşte bunlardan biri olan Hz. Aişe’nin Kur’an tefsirindeki rolü çok fazla bilinmemektedir. Biz bu makalede onun Kur’an tefsirine olan katkısını ortaya çıkarmak için Taberi Tefsiri’ni esas alarak rivayetlerini inceledik. Böylece Hz. Aişe’nin tefsir ilmindeki yerini ve metodunu tespit etmeye çalıştık
- Published
- 2010
41. A follow up study of cytomegalovirus infection in a group of Turkish renal transplant recipients using molecular assays
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Meltem Yalinay Cirak, Seyyal Rota, Isil Maral, Sevgi Turet, and Sukru Sindel
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cytomegalovirus ,polymerase chain reaction ,hybridization ,Microbiology ,QR1-502 ,Infectious and parasitic diseases ,RC109-216 - Abstract
The clinical value of an in-house cytomegalovirus nested polymerase chain reaction (CMV-PCR) and a commercial molecular assay hybrid capture CMV DNA assay (HCA) was evaluated in monitoring a group of renal transplant patients for six months follow up. In this study, the sensitivity, specificity, positive predictive value, and negative predictive value of nested CMV DNA PCR assay and HCA at the beginning of the study were 70, 42.9, 46.7, 66.7, and 60, 78.6, 66.7, and 73.3% respectively. After six months, they were 80, 66.7, 80, 66.7 for CMV PCR and 73.3, 88.9, 91.7, 66.7% for HCA respectively. These results indicate that in monitoring and predicting CMV infections in renal transplant recipients, not only qualitative but also quantitative assays must be used together in order to decide the preemptive strategies.
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- 2005
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42. ÖĞRENEN TOPLUMLARA DOĞRU AVRUPA BİRLİĞİ EĞİTİM POLİTİKALARINDA YAŞAM BOYU ÖĞRENME
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Sevgi Turan
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yaşam boyu öğrenme ,eği̇ti̇m ,toplum ,Political science ,Political science (General) ,JA1-92 - Abstract
Yaşam boyu öğrenme, örgün-yaygın her türlü eğitim faaliyetini kapsayan çok geniş bir kavramdır. Avrupa Birliği Komisyonu ’nun 2000 yılında Yaşam Boyu Öğrenme Memorandumu ’nu kabul ederek bu metnin hayata geçirilmesini tüm üye devletlerde ve aday ülkelerde tartışmaya açmasının yaşam boyu öğrenmenin gelişiminde olumlu bir rolü olduğu düşünülmektedir. Avrupa Birliği, yaşam boyu öğrenmeyi, "bilgi, beceri ve yeterliliği geliştirmek amacıyla belirli bir süreyle yapılan eğitim faaliyetlerinin tümü " şeklinde tanımlamaktadır.Yaşam boyu öğrenme istihdamla ilgili amaçlar kadar bireysel, vatandaşlık ve sosyal amaçları da kapsar. Formal eğitim sistemi içinde ve dışında farklı çevrelerde olabilir. Yaşam boyu öğrenme, insana ve bilgiye yatırımın artmasını, bilgisayar okuryazarlığı dâhil olmak üzere temel becerilerin edinilmesinin desteklenmesini ve yenilik için fırsatların genişletilmesini, öğrenmenin daha esnek formlarını içerir. Bu amaç, bireylerin yüksek kalitedeki öğrenme olanaklarına ve farklı öğrenme yaşantılarına eşit ve açık olarak ulaşmasının sağlanması içindir. Eğitim sistemi buna ulaşmada anahtar role sahiptir.
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- 2005
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43. A Review of Mid-Infrared and Near-Infrared Imaging: Principles, Concepts and Applications in Plant Tissue Analysis
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Sevgi Türker-Kaya and Christian W. Huck
- Subjects
plants ,mid-infrared ,near-infrared ,imaging ,microspectroscopy ,Organic chemistry ,QD241-441 - Abstract
Plant cells, tissues and organs are composed of various biomolecules arranged as structurally diverse units, which represent heterogeneity at microscopic levels. Molecular knowledge about those constituents with their localization in such complexity is very crucial for both basic and applied plant sciences. In this context, infrared imaging techniques have advantages over conventional methods to investigate heterogeneous plant structures in providing quantitative and qualitative analyses with spatial distribution of the components. Thus, particularly, with the use of proper analytical approaches and sampling methods, these technologies offer significant information for the studies on plant classification, physiology, ecology, genetics, pathology and other related disciplines. This review aims to present a general perspective about near-infrared and mid-infrared imaging/microspectroscopy in plant research. It is addressed to compare potentialities of these methodologies with their advantages and limitations. With regard to the organization of the document, the first section will introduce the respective underlying principles followed by instrumentation, sampling techniques, sample preparations, measurement, and an overview of spectral pre-processing and multivariate analysis. The last section will review selected applications in the literature.
- Published
- 2017
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44. Performance of reconstruction and identification of τ leptons decaying to hadrons and vτ in pp collisions at √s=13 TeV
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Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Asilar, E., Bergauer, T., Brandstetter, J., Dragicevic, M., Eroe, J., Del Valle, A. Escalante, Flechl, M., Fruehwirth, R., Ghete, V. M., Hrubec, J., Jeitler, M., Krammer, N., Kraetschmer, I., Liko, D., Madlener, T., Mikulec, I., Rad, N., Rohringer, H., Schieck, J., Schoefbeck, R., Spanring, M., Spitzbart, D., Taurok, A., Waltenberger, W., Wittmann, J., Wulz, C. -E., Zarucki, M., Chekhovsky, V., Mossolov, V., Gonzalez, J. Suarez, De Wolf, E. A., Di Croce, D., Janssen, X., Lauwers, J., Pieters, M., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Abu Zeid, S., Blekman, F., D'Hondt, J., De Bruyn, I., De Clercq, J., Deroover, K., Flouris, G., Lontkovskyi, D., Lowette, S., Marchesini, I., Moortgat, S., Moreels, L., Python, Q., Skovpen, K., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Parijs, I., Beghin, D., Bilin, B., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Dorney, B., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Kalsi, A. 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Manuel Olmedo Negrete, Mirena Ivova Paneva, Weinan, S, Long, W, Hua, W, Stephen, W, Brent, Y, James, G, Philip, C, Sergio, C, Mark, D, Raffaele, G, Dylan, G, Bobak, H, André, H, Daniel, K, Gouranga, K, James, L, Mario, M, Dominick, O, Sanjay, P, Matteo, S, Vivek, S, Sean, S, Matevz, T, Adish, V, Steven, W, John, W, Frank, W, Avraham, Y, Giovanni Zevi Della Porta, Nick, A, Rohan, B, John, B, Matthew, C, Adam, D, Valentina, D, Manuel Franco Sevilla, Loukas, G, Ryan, H, Joe, I, Ana, O, Huilin, Q, Jeffrey, R, Indara, S, Sicheng, W, Jaehyeok, Y, Dustin, A, Adolf, B, Jay Mathew Lawhorn, Harvey, B, Thong, N, Maria, S, Jean-Roch, V, Richard, W, Xie, S, Zhicai, Z, Ren-Yuan, Z, Michael Benjamin Andrews, Thomas, F, Tanmay, M, Manfred, P, Menglei, S, Igor, V, John Perry Cumalat, William, T, Frank, J, Andrew, J, Michael, K, Emily, M, Troy, M, Rishi, P, Kevin, S, Keith, U, Stephen Robert Wagner, James, A, Jorge, C, Yangyang, C, Jennifer, C, Abhisek, D, Kevin, M, Nathan, M, Juliet Ritchie Patterson, 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Andrew, W, Darin, A, Paul, A, Pierluigi, B, Dimitri, B, Luca, C, Andrew, C, Richard, D, Sergei, V, Bhargav Madhusudan Joshi, Jacobo, K, Andrey, K, Kin Ho Lo, Peisen, M, Konstantin, M, Hualin, M, Guenakh, M, Daniel, R, Kun, S, Jian, W, Sean-Jiun, W, Yagya Raj Joshi, Andrew, A, Todd, A, Sharon, H, Vasken, H, Kurtis, F, Ted, K, German, M, Thomas, P, Harrison, P, Anirban, S, Catherine, S, Rachel, Y, Marc, M, Vallary, B, Marcus, H, Daniel, N, Mehdi, R, Titas, R, Francisco, Y, Mark Raymond Adams, Leonard, A, Russell Richard Betts, Richard, C, Xuan, C, Susan, D, Olga, E, Cecilia Elena Gerber, Dhanush Anil Hangal, David Jonathan Hofman, Kurt, J, Jason, K, Corrinne, M, Irving Daniel Sandoval Gonzalez, Marguerite, T, Nikos, V, Hui, W, Xiao, W, Zhenbin, W, Jingyu, Z, Mohammad, A, Burak, B, Warren, C, Kamuran, D, Süleyman, D, Reddy Pratap Gandrajula, Maksat, H, Jean-Pierre, M, Alexi, M, Anthony, M, Jane, N, Hasan, O, Yasar, O, Ferhat, O, Aldo, P, Christina, S, Emrah, T, James, W, Barry, B, Alice, C, Nicholas, E, David, F, Lei, F, Andrei, G, Wai Ting Hung, Petar, M, Ulascan, S, Morris, S, Meng, X, Can, Y, Ayman, A, Philip, B, Alice, B, James, B, James, C, Sadia, K, Anna, K, Devdatta, M, William, M, Christopher, R, Stephen, S, Erich, S, Daniel Tapia Takaki, Quan, W, Senka, D, Andrew, I, Ketino, K, Doyeong, K, Yurii, M, Dalath Rachitha Mendis, Tyler, M, Atanu, M, Abdollah, M, Lovedeep Kaur Saini, Nikoloz, S, Finn, R, Douglas, W, Drew, B, Owen, B, Sarah Catherine Eno, Yongbin, F, Charles, F, Nicholas John Hadley, Shabnam, J, Geng-Yuan, J, Richard, G, Joshua, K, Francesca, R, Young Ho Shin, Andris, S, Suresh, C, Kak, W, Brandon, A, Virginia, A, Gerry, B, Ran, B, Wit, B, Ivan Amos Cali, Mariarosaria, D, Zeynep, D, Guillelmo Gomez Ceballos, Maxim, G, Dylan, H, Miao, H, Yutaro, I, Gian Michele Innocenti, Markus, K, Dmytro, K, Yen-Jie, L, Paul David Luckey, Benedikt, M, Andrea Carlo Marini, Camelia, M, Siddharth, N, Xinmei, N, Christoph, P, Christof, R, Gunther, R, George, S, Konstanty, S, Kaya, T, Dragos, V, Jing, W, Ta-Wei, W, Bolek, W, Zhaozhong, S, Rajdeep Mohan Chatterjee, Andrew, E, Peter, H, Sean, K, Yuichi, K, Zachary, L, Jeremy, M, Nicole, R, Roger, R, Jared, T, Mohammad Abrar Wadud, John Gabriel Acosta, Sandra, O, Ekaterina, A, Kenneth, B, Caleb, F, Rebeca Gonzalez Suarez, Rami, K, Ilya, K, Joaquin Emilo Siado, Benjamin, S, Charles, H, Iashvili, I, Avto, K, Christine, M, Duong, N, Ashley, P, Salvatore, R, Bahareh, R, George, A, Emanuela, B, Apichart, H, David Michael Morse, Toyoko, O, Rafael Teixeira De Lima, Tanvi, W, Bingran, W, Darien, W, Saptaparna, B, Otman, C, Kristan Allan Hahn, Nicholas, M, Nathaniel, O, Michael Henry Schmitt, Marco, T, Mayda, V, Rachael, B, Nabarun, D, Michael, H, Kenyi Hurtado Anampa, Colin, J, Daniel John Karmgard, Nathan, K, Kevin, L, Wenzhao, L, Nikitas, L, Nancy, M, Fanbo, M, Charles, M, Yuri, M, Allison, R, Randy, R, Prasanna, S, Geoffrey, S, Silvia, T, Mitchell, W, Matthias, W, Anna, W, Juliette, A, Louis, A, Ben, B, Lloyd Stanley Durkin, Sean, F, Brian, F, Andrew, H, Christopher, H, Weifeng, J, Ta-Yung, L, Wuming, L, Brian, L, Howard Wells Wulsin, Stephane, C, Peter, E, Joshua, H, Samuel, H, Alexis, K, David, L, Marco Toliman Lucchini, Jingyu, L, Daniel, M, Kelvin, M, Isabel, O, James, O, Christopher, P, Pierre, P, Jakob, S, Christopher, T, Sudhir, M, Scarlet, N, Anthony, B, Virgil, E, Souvik, D, Laszlo, G, Matthew, J, Andreas Werner Jung, Ajeeta, K, Bibhuprasad, M, David Harry Miller, Norbert, N, Cheng-Chieh, P, Stefan, P, Hao, Q, Jan-Frederik, S, Jian, S, Fuqiang, W, Rui, X, Wei, X, Tongguang, C, James, D, Neeti, P, Zhenyu, C, Karl Matthew Ecklund, Sarah, F, Frank JM Geurts, Matthew, K, Wei, L, Brian Paul Padley, Jay, R, Jamal, R, Wei, S, Zhoudunming, T, James, Z, Aobo, Z, Arie, B, Pawel de Barbaro, Regina, D, Yi-ting, D, Joseph Lynn Dulemba, Colin, F, Mario, G, Aran, G, Jiyeon, H, Otto, H, Aleko, K, Ping, T, Rhys, T, Antonis, A, John Paul Chou, Yuri, G, Eva, H, Maximilian, H, Elliot, H, Steven, K, Raghav Kunnawalkam Elayavalli, Savvas, K, Amitabh, L, Roy, M, Kevin, N, Marc, O, Halil, S, Sevil, S, Steve, S, Sunil, S, Scott, T, Peter, T, Matthew, W, Andrés, G, Joseph, H, Grant, R, Stefan, S, Othmane, B, Ali, C, Mykhailo, D, Marco De Mattia, Andrea, D, Sven, D, Ricardo, E, Jason, G, Tao, H, Teruki, K, Sifu, L, Ryan, M, Alexx, P, Denis, R, Alexei, S, Nural, A, Jordan, D, DE GUIO, F, Phillip Russell Dudero, Shuichi, K, Kamal, L, Sung Won Lee, Tielige, M, Samila, M, Timo, P, Sonaina, U, Zhixing, W, Senta, G, Alfredo, G, Ravi, J, Willard, J, Andrew, M, Hong, N, Klaas, P, José David Ruiz Alvarez, Shengquan, T, Julia, V, Marta, V, Qiao, X, Michael Wayne Arenton, Patrizia, B, Bradley, C, Robert, H, Hengne, L, Christopher, N, Tutanon, S, Yanchu, W, Evan, W, Fan, X, Paul Edmund Karchin, Nabin, P, Jared, S, Prakash, T, Shawn, Z, Michael, B, Cécile, C, Duncan, C, Sridhara, D, Laura, D, Bhawna, G, Monika, G, Matthew, H, Alain, H, Usama, H, Pamela, K, Armando, L, Kenneth, L, Tyler, R, Varun, S, Nicholas, S, Wesley, H, Nathaniel, W, Lucchini, M, Department of Physics, Helsinki Institute of Physics, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CMS, Elementary Particle Physics, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, Çukurova Üniversitesi, Fen-Edebiyat Fakültesi, Fizik Bölümü, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Karapınar, Güler, Izmir Institute of Technology. Mathematics, CMS Collaboration, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Yerevan Phys Inst, Inst Hochenergiephys, Inst Nucl Problems, Univ Antwerp, Vrije Univ Brussel, Univ Libre Bruxelles, Univ Ghent, Catholic Univ Louvain, Ctr Brasileiro Pesquisas Fis, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Estadual Paulista (Unesp), Universidade Federal do ABC (UFABC), Bulgarian Acad Sci, Univ Sofia, Beihang Univ, Inst High Energy Phys, Peking Univ, Tsinghua Univ, Univ Los 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University, Işıldak, Bora, Sirunyan, A.M., Tumasyan, A., Adam, W., Ambrogi, F., Asilar, E., Bergauer, T., Brandstetter, J., Dragicevic, M., Erö, J., Valle, A. 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Calderon De La Barca, Chertok, M., Conway, J., Conway, R., Cox, P.T., Erbacher, R., Flores, C., Funk, G., Ko, W., Kukral, O., Lander, R., Mulhearn, M., Pellett, D., Pilot, J., Shalhout, S., Shi, M., Stolp, D., Taylor, D., Tos, K., Tripathi, M., Zhang, F., Bachtis, M., Bravo, C., Cousins, R., Dasgupta, A., Florent, A., Hauser, J., Ignatenko, M., McColl, N., Regnard, S., Saltzberg, D., Schnaible, C., Valuev, V., Bouvier, E., Burt, K., Clare, R., Gary, J.W., Shirazi, S.M.A. Ghiasi, Hanson, G., Karapostoli, G., Kennedy, E., Lacroix, F., Long, O.R., Negrete, M. Olmedo, Paneva, M.I., Si, W., Wang, L., Wei, H., Wimpenny, S., Yates, B.R., Branson, J.G., Cittolin, S., Derdzinski, M., Gerosa, R., Gilbert, D., Hashemi, B., Holzner, A., Klein, D., Kole, G., Krutelyov, V., Letts, J., Masciovecchio, M., Olivito, D., Padhi, S., Pieri, M., Sani, M., Sharma, V., Simon, S., Tadel, M., Vartak, A., Wasserbaech, S., Wood, J., Würthwein, F., Yagil, A., Porta, G. Zevi Della, Amin, N., Bhandari, R., Bradmiller-Feld, J., Campagnari, C., Citron, M., Dishaw, A., Dutta, V., Sevilla, M. 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Sandoval, Tonjes, M.B., Varelas, N., Wang, H., Wang, X., Wu, Z., Zhang, J., Alhusseini, M., Bilki, B., Clarida, W., Dilsiz, K., Durgut, S., Gandrajula, R.P., Haytmyradov, M., Khristenko, V., Merlo, J.-P., Mestvirishvili, A., Moeller, A., Nachtman, J., Ogul, H., Onel, Y., Ozok, F., Penzo, A., Snyder, C., Tiras, E., Wetzel, J., Blumenfeld, B., Cocoros, A., Eminizer, N., Fehling, D., Feng, L., Gritsan, A.V., Hung, W.T., Maksimovic, P., Roskes, J., Sarica, U., Swartz, M., Xiao, M., You, C., Al-Bataineh, A., Baringer, P., Bean, A., Boren, S., Bowen, J., Bylinkin, A., Castle, J., Khalil, S., Kropivnitskaya, A., Majumder, D., McBrayer, W., Murray, M., Rogan, C., Sanders, S., Schmitz, E., Takaki, J.D. Tapia, Duric, S., Ivanov, A., Kaadze, K., Kim, D., Maravin, Y., Mendis, D.R., Mitchell, T., Modak, A., Mohammadi, A., Saini, L.K., Skhirtladze, N., Rebassoo, F., Wright, D., Baden, A., Baron, O., Belloni, A., Eno, S.C., Feng, Y., Ferraioli, C., Hadley, N.J., Jabeen, S., Jeng, G.Y., Kellogg, R.G., Kunkle, J., Mignerey, A.C., Ricci-Tam, F., Shin, Y.H., Skuja, A., Tonwar, S.C., Wong, K., Abercrombie, D., Allen, B., Azzolini, V., Baty, A., Bauer, G., Bi, R., Brandt, S., Busza, W., Cali, I.A., D'Alfonso, M., Demiragli, Z., Ceballos, G. Gomez, Goncharov, M., Harris, P., Hsu, D., Hu, M., Iiyama, Y., Innocenti, G.M., Klute, M., Kovalskyi, D., Lee, Y.-J., Luckey, P.D., Maier, B., Marini, A.C., McGinn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Roland, C., Roland, G., Stephans, G.S.F., Sumorok, K., Tatar, K., Velicanu, D., Wang, T.W., Wyslouch, B., Zhaozhong, S., Benvenuti, A.C., Chatterjee, R.M., Evans, A., Hansen, P., Kalafut, S., Kubota, Y., Lesko, Z., Mans, J., Ruckstuhl, N., Rusack, R., Turkewitz, J., Wadud, M.A., Acosta, J.G., Oliveros, S., Avdeeva, E., Bloom, K., Claes, D.R., Fangmeier, C., Golf, F., Suarez, R. Gonzalez, Kamalieddin, R., Kravchenko, I., Monroy, J., Siado, J.E., Snow, G.R., Stieger, B., Godshalk, A., Harrington, C., Iashvili, I., Kharchilava, A., McLean, C., Nguyen, D., Parker, A., Rappoccio, S., Roozbahani, B., Alverson, G., Barberis, E., Freer, C., Hortiangtham, A., Morse, D.M., Orimoto, T., Lima, R. Teixeira De, Wamorkar, T., Wang, B., Wisecarver, A., Wood, D., Charaf, O., Hahn, K.A., Mucia, N., Odell, N., Schmitt, M.H., Sung, K., Trovato, M., Velasco, M., Bucci, R., Dev, N., Hildreth, M., Anampa, K. Hurtado, Jessop, C., Karmgard, D.J., Kellams, N., Lannon, K., Li, W., Loukas, N., Marinelli, N., Meng, F., Mueller, C., Musienko, Y., Planer, M., Reinsvold, A., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Woodard, A., Alimena, J., Antonelli, L., Bylsma, B., Durkin, L.S., Flowers, S., Francis, B., Hart, A., Hill, C., Ji, W., Ling, T.Y., Luo, W., Winer, B.L., Wulsin, H.W., Cooperstein, S., Elmer, P., Hardenbrook, J., Higginbotham, S., Kalogeropoulos, A., Lange, D., Lucchini, M.T., Luo, J., Marlow, D., Mei, K., Ojalvo, I., Olsen, J., Palmer, C., Piroué, P., Salfeld-Nebgen, J., Stickland, D., Tully, C., Norberg, S., Barker, A., Barnes, V.E., Das, S., Gutay, L., Jones, M., Jung, A.W., Khatiwada, A., Mahakud, B., Miller, D.H., Neumeister, N., Peng, C.C., Piperov, S., Qiu, H., Schulte, J.F., Sun, J., Wang, F., Xiao, R., Xie, W., Cheng, T., Dolen, J., Parashar, N., Chen, Z., Ecklund, K.M., Freed, S., Geurts, F.J.M., Kilpatrick, M., Padley, B.P., Roberts, J., Rorie, J., Shi, W., Tu, Z., Zabel, J., Zhang, A., Bodek, A., De Barbaro, P., Demina, R., Duh, Y.T., Dulemba, J.L., Fallon, C., Ferbel, T., Galanti, M., Garcia-Bellido, A., Han, J., Hindrichs, O., Khukhunaishvili, A., Tan, P., Taus, R., Agapitos, A., Chou, J.P., Gershtein, Y., Halkiadakis, E., Heindl, M., Hughes, E., Kaplan, S., Elayavalli, R. Kunnawalkam, Kyriacou, S., Lath, A., Montalvo, R., Nash, K., Osherson, M., Saka, H., Salur, S., Schnetzer, S., Sheffield, D., Somalwar, S., Stone, R., Thomas, S., Thomassen, P., Walker, M., Delannoy, A.G., Heideman, J., Riley, G., Spanier, S., Bouhali, O., Celik, A., Dalchenko, M., Mattia, M. De, Delgado, A., Dildick, S., Eusebi, R., Gilmore, J., Huang, T., Kamon, T., Luo, S., Mueller, R., Perloff, A., Pernie, L., Rathjens, D., Safonov, A., Akchurin, N., Damgov, J., Guio, F. De, Dudero, P.R., Kunori, S., Lamichhane, K., Mengke, T., Muthumuni, S., Peltola, T., Undleeb, S., Volobouev, I., Greene, S., Gurrola, A., Janjam, R., Johns, W., Maguire, C., Melo, A., Ni, H., Padeken, K., Alvarez, J.D. Ruiz, Sheldon, P., Tuo, S., Velkovska, J., Verweij, M., Xu, Q., Arenton, M.W., Barria, P., Cox, B., Hirosky, R., Joyce, M., Ledovskoy, A., Li, H., Neu, C., Sinthuprasith, T., Wolfe, E., Xia, F., Harr, R., Karchin, P.E., Poudyal, N., Sturdy, J., Thapa, P., Zaleski, S., Brodski, M., Buchanan, J., Caillol, C., Carlsmith, D., Dasu, S., Dodd, L., Gomber, B., Grothe, M., Herndon, M., Hervé, A., Hussain, U., Klabbers, P., Lanaro, A., Long, K., Loveless, R., Ruggles, T., Savin, A., Smith, N., Smith, W.H., and Woods, N.
- Subjects
Technology ,Compact Muon Solenoid ,Physics::Instrumentation and Detectors ,13000 GeV-cms ,particle identification: efficiency ,PROTON-PROTON COLLISIONS ,Hadron ,Performance of High Energy Physics Detector ,Particle identification methods ,01 natural sciences ,7. Clean energy ,030218 nuclear medicine & medical imaging ,High Energy Physics - Experiment ,tau: particle identification ,Particle identification methods ,0302 clinical medicine ,particle identification [tau] ,scattering [p p] ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Nuclear Experiment ,Instrumentation ,Instruments & Instrumentation ,Mathematical Physics ,Boson ,Large detector-systems performance ,Physics ,Large Hadron Collider ,Luminosity (scattering theory) ,efficiency [particle identification] ,tau: pair production ,track data analysis ,CMS ,Settore FIS/01 - Fisica Sperimentale ,Performance of High Energy Physics Detectors ,BOSON ,Monte Carlo [numerical calculations] ,CMS collaboration ,particle tracking detectors ,particle identification methods ,large detector-system performance ,proton-proton collisions ,Nuclear & Particles Physics ,CERN LHC Coll ,pair production [tau] ,Physique des particules élémentaires ,pi0: particle identification ,PARTICLE PHYSICS ,Neutrino ,colliding beams [p p] ,numerical calculations: Monte Carlo ,CROSS-SECTION ,Particle Physics - Experiment ,performance ,Particle physics ,data analysis method ,p p: scattering ,Large detector-systems performance, Particle identification methods, Performance of High Energy Physics Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,SEARCH ,NEUTRINO ,PAIR ,boosted particle ,114 Physical sciences ,03 medical and health sciences ,Particle identification method ,High energy physics detectors ,Performance of HighEnergyPhysicsDetectors ,0103 physical sciences ,LHC,CMS ,ddc:610 ,particle identification [pi0] ,010306 general physics ,tau: hadronic decay ,Muon ,Science & Technology ,LARGE HADRON COLLIDER ,010308 nuclear & particles physics ,hep-ex ,High Energy Physics::Phenomenology ,Particle İdentification Methods ,high energy physics ,experimental particle physics ,LHC ,standard model ,trigger ,Pair production ,Physics and Astronomy ,High Energy Physics::Experiment ,hadronic decay [tau] ,p p: colliding beams ,ddc:600 ,Lepton ,experimental results - Abstract
Journal of Instrumentation 13(10), P10005 (2018). doi:10.1088/1748-0221/13/10/P10005, The algorithm developed by the CMS Collaboration to reconstruct and identify τ leptons produced in proton-proton collisions at $\sqrt{s}=$7 and 8 TeV, via their decays to hadrons and a neutrino, has been significantly improved. The changes include a revised reconstruction of $π^0$ candidates, and improvements in multivariate discriminants to separate τ leptons from jets and electrons. The algorithm is extended to reconstruct $τ$ leptons in highly Lorentz-boosted pair production, and in the high-level trigger. The performance of the algorithm is studied using proton-proton collisions recorded during 2016 at $\sqrt{s}=$13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The performance is evaluated in terms of the efficiency for a genuine $τ$ lepton to pass the identification criteria and of the probabilities for jets, electrons, and muons to be misidentified as $τ$ leptons. The results are found to be very close to those expected from Monte Carlo simulation., Published by Inst. of Physics, London
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- 2018
- Full Text
- View/download PDF
45. The effects of the posttraumatic stress and general health status on paediatric burns and their sleep habits.
- Author
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Düken ME, Yayan EH, Zengin M, and Sevgi T
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- Child, Humans, Male, Adolescent, Female, Hospitalization, Sleep, Health Status, Burns complications, Burns epidemiology, Burns psychology, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Sleep Wake Disorders epidemiology
- Abstract
Background: Burns are serious injuries that can require hospitalization and have physical and emotional sequelae. Sleep disturbance can occur after trauma as evidenced by posttraumatic stress symptoms such as re-experiencing of a trauma with repetitive dreams, memories and flashbacks. This area has been minimally examined with pediatric burn survivors; therefore, the aim of this study was to investigate the effects of posttraumatic stress and general health on sleep habits of pediatric burn survivors from., Method: This is a correlational descriptive study. Its sample included 7-18-year-old inpatients at the burn clinic of a university hospital from January to November 2019. This study used the Posttraumatic Stress Disorder Reaction Index, the General Health Questionnaire (12) and the Children's Sleep Habits Questionnaire for data collection., Results: Of the participants, 58.6% were male, 46.5% were primary school students, and 62.6% had no diseases other than their burns. 20.2% of the children had epilepsy, 14.2% had diabetes and 3% had pneumonia. Of the child burn victims, 45.5% were brought to the hospital because of contact with fire. All of them had first-degree burns, 59.6% had second-degree burns, and 80.8% had third-degree burns. After their burns, infections developed in 20.2% during trauma and in 43.4% during burn treatment. A structural equation model indicated that the child burn victims' general health perceptions did not significantly affect their sleep habits (p > 0.05). A significant correlation was found between the children's posttraumatic stress disorder and their sleep habits (p < 0.05). Posttraumatic stress disorder explained 7.2% of their sleep habits. A positive and significant correlation was found between the children's general health perceptions and posttraumatic stress disorder (r = 0.74, p < 0.05)., Conclusion: Burns of any kind can cause posttraumatic stress, sleep disorders and impairment of health status in children., (Copyright © 2022 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
- Published
- 2023
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46. Synthesis and crystal structures of novel copper(II) complexes with glycine and substituted phenanthrolines: reactivity towards DNA/BSA and in vitro cytotoxic and antimicrobial evaluation.
- Author
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İnci D, Aydın R, Vatan Ö, Sevgi T, Yılmaz D, Zorlu Y, Yerli Y, Çoşut B, Demirkan E, and Çinkılıç N
- Subjects
- Animals, Anti-Infective Agents chemical synthesis, Anti-Infective Agents chemistry, Anti-Infective Agents metabolism, Anti-Infective Agents pharmacology, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents metabolism, Antineoplastic Agents pharmacology, Cattle, Chemistry Techniques, Synthetic, Crystallography, X-Ray, DNA Cleavage drug effects, Models, Molecular, Molecular Conformation, Copper chemistry, DNA metabolism, Glycine chemistry, Phenanthrolines chemistry, Serum Albumin, Bovine metabolism
- Abstract
New copper(II) complexes-dimeric-[Cu(nphen)(gly)(H
2 O)]+ (1) and [Cu(dmphen)(gly)(NO3 )(H2 O)] (2) (nphen = 5-nitro-1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline, and gly = glycine)-have been synthesized and characterized by CHN analysis, single-crystal X-ray diffraction techniques, FTIR, EPR spectroscopy, and cyclic voltammetry. The CT-DNA-binding properties of these complexes have been investigated by thermal denaturation measurements and both absorption and emission spectroscopy. The DNA cleavage activity of these complexes has been studied on supercoiled pUC19 plasmid DNA by gel electrophoresis experiments in the absence and presence of H2 O2 . Furthermore, the interaction of these complexes with bovine serum albumin (BSA) has been investigated using absorption and emission spectroscopy. The thermodynamic parameters, free-energy change (ΔG), enthalpy change (ΔH), and entropy change (ΔS) for BSA + complexes 1 and 2 systems have been calculated by the van't Hoff equation at three different temperatures (293.2, 303.2, and 310.2 K). The distance between the BSA and these complexes has been determined using fluorescence resonance energy transfer (FRET). Conformational changes of BSA have been observed using the synchronous fluorescence technique. In addition, in vitro cytotoxicities of these complexes on tumor cell lines (Caco-2, A549, and MCF-7) and healthy cells (BEAS-2B) have been examined. The antimicrobial activity of the complexes has also been tested on certain bacteria cells. The effect of mono and dimeric in the above complexes is presented and discussed. New copper(II) complexes-dimeric-[Cu(nphen)(gly)(H2 O)]+ (1) and [Cu(dmphen)(gly) (NO3 )(H2 O)] (2) (nphen = 5-nitro-1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline and gly = glycine)-have been synthesized and characterized by CHN analysis, single-crystal X-ray diffraction techniques, FTIR and EPR spectroscopy. They have been tested for their in vitro DNA/BSA interactions by the spectroscopic methods. These complexes exhibited higher cytotoxic and antimicrobial activities. Complex 1 shows better DNA / BSA interactions in comparison to complex 2.- Published
- 2017
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47. HPLC fluorescence method for the determination of nizatidine in human plasma and its application to pharmacokinetic study.
- Author
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Çakar MB and Ulu ST
- Subjects
- Chromatography, High Pressure Liquid instrumentation, Fluorescence, Histamine H2 Antagonists pharmacokinetics, Humans, Nizatidine pharmacokinetics, Chromatography, High Pressure Liquid methods, Histamine H2 Antagonists blood, Nizatidine blood
- Abstract
A sensitive high-performance liquid chromatographic (HPLC) method was developed for the determination of nizatidine in human plasma. Nizatidine was derivatized by 4-fluoro-7-nitrobenzofurazan (NBD-F). Chromatographic separation was performed on a Inertsil C18 column (150 mm × 4.6 mm, 5 µm) using isocratic elution by a mobile phase consisting of methanol/water (55:45) at a flow rate of 1.2 mL/min. Amlodipine was used as the internal standard (IS). Fluorescence detector was used operated at 461 nm (excitation) and 517 nm (emission), respectively. The calibration curve was linear over the range of 50-2000 ng/mL. This method was successfully applied to a pharmacokinetic study after oral administration of a dose (150 mg) of nizatidine., (Copyright © 2013 John Wiley & Sons, Ltd.)
- Published
- 2014
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