Search

Your search keyword '"Severus E"' showing total 208 results
Start Over Author "Severus E"
208 results on '"Severus E"'

2. Future directions in the field of Bipolar Disorder

Author

Reininghaus, E.Z., primary, Dalkner, N., additional, L, Wels, additional, Stijic, M., additional, Bechdolf, A., additional, Bellivier, F., additional, Bergink, V., additional, Ceylan, D., additional, Correll, C.U., additional, Etain, B., additional, Fagiolini, A., additional, Geddes, J., additional, Gonzalez-Pinto, A., additional, Goodwin, G., additional, Hajek, T., additional, Henry, C., additional, Kessing, L.V., additional, Kupka, R., additional, Lagerberg, T.V., additional, Landen, M., additional, Licht, R.W., additional, Martinez-Cengotitabengoa, M., additional, Morken, G., additional, Nielsen, R.E., additional, Rietschel, M., additional, Ritter, P., additional, Schulze, T., additional, Scott, J., additional, Severus, E., additional, Squassina, A., additional, Suwalska, A., additional, Vieta, E., additional, Yildiz, A., additional, Reif, A., additional, Manchia, M., additional, and Andreassen, O.A., additional

Published
2024
Full Text
View/download PDF

7. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Andreassen, O.A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R.H., Berk, M., Bjella, T.D., Bossini, L., Bersudsky, Y., Cheung, E.Y.W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M.A., Fountoulakis, K.N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsä, E.T., Kapczinski, F., Kliwicki, S., König, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E.R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F.G., O’Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J.K., Sagduyu, K., Scippa, A.M., Severus, E., Simhandl, C., Stein, D.J., Strejilevich, S., Hatim Sulaiman, A., Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M.J., Zetin, M., and Whybrow, P.C.

Published
2015
Full Text
View/download PDF

10. Solar insolation in springtime influences age of onset of bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Aleksandrovich, M. A., Andreassen, O. A., Angelopoulos, E., Ardau, R., Ayhan, Y., Baethge, C., Bharathram, S. R., Bauer, R., Baune, B. T., Becerra‐Palars, C., Bellivier, F., Belmaker, R. H., Berk, M., Bersudsky, Y., Bicakci, Ş., Birabwa‐Oketcho, H., Bjella, T. D., Bossini, L., Cabrera, J., Cheung, E. Y. W., Del Zompo, M., Dodd, S., Donix, M., Etain, B., Fagiolini, A., Fountoulakis, K. N., Frye, M. A., Gonzalez‐Pinto, A., Gottlieb, J. F., Grof, P., Harima, H., Henry, C., Isometsä, E. T., Janno, S., Kapczinski, F., Kardell, M., Khaldi, S., Kliwicki, S., König, B., Kot, T. L., Krogh, R., Kunz, M., Lafer, B., Landén, M., Larsen, E. R., Lewitzka, U., Licht, R. W., Lopez‐Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez‐Cengotitabengoa, M., Melle, I., Meza‐Urzúa, F., Yee Ming, M., Monteith, S., Morken, G., Mosca, E., Munoz, R., Mythri, S. V., Nacef, F., Nadella, R. K., Nery, F. G., Nielsen, R. E., OʼDonovan, C., Omrani, A., Osher, Y., Østermark Sørensen, H., Ouali, U., Pica Ruiz, Y., Pilhatsch, M., Pinna, M., da Ponte, F. D. R., Quiroz, D., Ramesar, R., Rasgon, N., Reddy, M. S., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, Â. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Subramaniam, M., Sulaiman, A. H., Suominen, K., Tagata, H., Tatebayashi, Y., Tondo, L., Torrent, C., Vaaler, A. E., Veeh, J., Vieta, E., Viswanath, B., Yoldi‐Negrete, M., Zetin, M., Zgueb, Y., and Whybrow, P. C.

Published
2017
Full Text
View/download PDF

15. Future directions in the field of Bipolar Disorder

Author

Bauer, M., Bechdolf, A., Bellivier, F., Bergink, V., Ceylan, D., Correll, C.U., Etain, B., Fagiolini, A., Geddes, J., Gonzalez-Pinto, A., Goodwin, G., Hajek, T., Henry, C., Kessing, L.V., Kupka, R., Lagerberg, T.V., Landen, M., Licht, R.W., Martinez-Cengotitabengoa, M., Morken, G., Nielsen, R.E., Rietschel, M., Ritter, P., Schulze, T., Scott, J., Severus, E., Squassina, A., Suwalska, A., Vieta, E., Yildiz, A., Reininghaus, E.Z., Dalkner, N., Wels, L., Stijic, M., Reif, A., Manchia, M., and Andreassen, O.A.

Published
2024
Full Text
View/download PDF

17. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Author

Bauer, M. Glenn, T. Achtyes, E.D. Alda, M. Agaoglu, E. Altınbaş, K. Andreassen, O.A. Angelopoulos, E. Ardau, R. Vares, E.A. Aydin, M. Ayhan, Y. Baethge, C. Bauer, R. Baune, B.T. Balaban, C. Becerra-Palars, C. Behere, A.P. Behere, P.B. Belete, H. Belete, T. Belizario, G.O. Bellivier, F. Belmaker, R.H. Benedetti, F. Berk, M. Bersudsky, Y. Bicakci, Ş. Birabwa-Oketcho, H. Bjella, T.D. Brady, C. Cabrera, J. Cappucciati, M. Castro, A.M.P. Chen, W.-L. Cheung, E.Y.W. Chiesa, S. Crowe, M. Cuomo, A. Dallaspezia, S. Del Zompo, M. Desai, P. Dodd, S. Donix, M. Etain, B. Fagiolini, A. Fellendorf, F.T. Ferensztajn-Rochowiak, E. Fiedorowicz, J.G. Fountoulakis, K.N. Frye, M.A. Geoffroy, P.A. Gonzalez-Pinto, A. Gottlieb, J.F. Grof, P. Haarman, B.C.M. Harima, H. Hasse-Sousa, M. Henry, C. Høffding, L. Houenou, J. Imbesi, M. Isometsä, E.T. Ivkovic, M. Janno, S. Johnsen, S. Kapczinski, F. Karakatsoulis, G.N. Kardell, M. Kessing, L.V. Kim, S.J. König, B. Kot, T.L. Koval, M. Kunz, M. Lafer, B. Landén, M. Larsen, E.R. Lenger, M. Lewitzka, U. Licht, R.W. Lopez-Jaramillo, C. MacKenzie, A. Madsen, H.Ø. Madsen, S.A.K.A. Mahadevan, J. Mahardika, A. Manchia, M. Marsh, W. Martinez-Cengotitabengoa, M. Martiny, K. Mashima, Y. McLoughlin, D.M. Meesters, Y. Melle, I. Meza-Urzúa, F. Ming, M.Y. Monteith, S. Moorthy, M. Morken, G. Mosca, E. Mozzhegorov, A.A. Munoz, R. Mythri, S.V. Nacef, F. Nadella, R.K. Nakanotani, T. Nielsen, R.E. O‘Donovan, C. Omrani, A. Osher, Y. Ouali, U. Pantovic-Stefanovic, M. Pariwatcharakul, P. Petite, J. Pfennig, A. Ruiz, Y.P. Pilhatsch, M. Pinna, M. Pompili, M. Porter, R. Quiroz, D. Rabelo-da-Ponte, F.D. Ramesar, R. Rasgon, N. Ratta-apha, W. Ratzenhofer, M. Redahan, M. Reddy, M.S. Reif, A. Reininghaus, E.Z. Richards, J.G. Ritter, P. Rybakowski, J.K. Sathyaputri, L. Scippa, Â.M. Simhandl, C. Severus, E. Smith, D. Smith, J. Stackhouse, P.W., Jr. Stein, D.J. Stilwell, K. Strejilevich, S. Su, K.-P. Subramaniam, M. Sulaiman, A.H. Suominen, K. Tanra, A.J. Tatebayashi, Y. Teh, W.L. Tondo, L. Torrent, C. Tuinstra, D. Uchida, T. Vaaler, A.E. Veeh, J. Vieta, E. Viswanath, B. Yoldi-Negrete, M. Yalcinkaya, O.K. Young, A.H. Zgueb, Y. Whybrow, P.C.

Abstract

Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed. © 2021, The Author(s).

Published
2021

18. Corrigendum to 'Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action [European Neuropsychopharmacology (2020) 36, 121–136]' (European Neuropsychopharmacology (2020) 36 (121–136), (S0924977X20301802), (10.1016/j.euroneuro.2020.05.006)

Author

Manchia, M., Vieta, E., Smeland, O. B., Altimus, C., Bechdolf, A., Bellivier, F., Bergink, V., Fagiolini, A., Geddes, J. R., Hajek, T., Henry, C., Kupka, R., Lagerberg, T. V., Licht, R. W., Martinez-Cengotitabengoa, M., Morken, G., Nielsen, R. E., Gonzalez-Pinto, A., Reif, A., Rietschel, M., Ritter, P., Schulze, T. G., Scott, J., Severus, E., Yildiz, A., Kessing, L. V., Bauer, M., Goodwin, G. M., and Andreassen, O. A.

Published
2021

19. Corrigendum to “Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action [European Neuropsychopharmacology (2020) 36, 121–136]” (European Neuropsychopharmacology (2020) 36 (121–136), (S0924977X20301802), (10.1016/j.euroneuro.2020.05.006))

Author

Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), González-Pinto, A. (Ana), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), Andreassen, O.A. (Ole), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), González-Pinto, A. (Ana), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), and Andreassen, O.A. (Ole)

Abstract

The authors regret that there was an error in the author list, this should appear as above. The authors apologise for any inconvenience caused.

Published
2021
Full Text
View/download PDF

20. Corrigendum to 'Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action [European Neuropsychopharmacology (2020) 36, 121-136]'.

Author

Manchia, M, Vieta, E, Smeland, OB, Altimus, C, Bechdolf, A, Bellivier, F, Bergink, V, Fagiolini, A, Geddes, JR, Hajek, T, Henry, C, Kupka, R, Lagerberg, TV, Licht, RW, Martinez-Cengotitabengoa, M, Morken, G, Nielsen, RE, González-Pinto, A, Reif, A, Rietschel, M, Ritter, P, Schulze, TG, Scott, J, Severus, E, Yildiz, A, Kessing, LV, Bauer, M, Goodwin, GM, Andreassen, OA, European College of Neuropsychopharmacology (ECNP) Bipolar Disorders Network, Manchia, M, Vieta, E, Smeland, OB, Altimus, C, Bechdolf, A, Bellivier, F, Bergink, V, Fagiolini, A, Geddes, JR, Hajek, T, Henry, C, Kupka, R, Lagerberg, TV, Licht, RW, Martinez-Cengotitabengoa, M, Morken, G, Nielsen, RE, González-Pinto, A, Reif, A, Rietschel, M, Ritter, P, Schulze, TG, Scott, J, Severus, E, Yildiz, A, Kessing, LV, Bauer, M, Goodwin, GM, Andreassen, OA, and European College of Neuropsychopharmacology (ECNP) Bipolar Disorders Network

Published
2021

21. DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis - A narrative review from the ECNP bipolar disorders network.

Author

Kessing, LV, González-Pinto, A, Fagiolini, A, Bechdolf, A, Reif, A, Yildiz, A, Etain, B, Henry, C, Severus, E, Reininghaus, EZ, Morken, G, Goodwin, GM, Scott, J, Geddes, JR, Rietschel, M, Landén, M, Manchia, M, Bauer, M, Martinez-Cengotitabengoa, M, Andreassen, OA, Ritter, P, Kupka, R, Licht, RW, Nielsen, RE, Schulze, TG, Hajek, T, Lagerberg, TV, Bergink, V, Vieta, E, Kessing, LV, González-Pinto, A, Fagiolini, A, Bechdolf, A, Reif, A, Yildiz, A, Etain, B, Henry, C, Severus, E, Reininghaus, EZ, Morken, G, Goodwin, GM, Scott, J, Geddes, JR, Rietschel, M, Landén, M, Manchia, M, Bauer, M, Martinez-Cengotitabengoa, M, Andreassen, OA, Ritter, P, Kupka, R, Licht, RW, Nielsen, RE, Schulze, TG, Hajek, T, Lagerberg, TV, Bergink, V, and Vieta, E

Abstract

This narrative review summarizes and discusses the implications of the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 and the upcoming International Classification of Diseases (ICD)-11 classification systems on the prevalence of bipolar disorder and on the validity of the DSM-5 diagnosis of bipolar disorder according to the Robin and Guze criteria of diagnostic validity. Here we review and discuss current data on the prevalence of bipolar disorder diagnosed according to DSM-5 versus DSM-IV, and data on characteristics of bipolar disorder in the two diagnostic systems in relation to extended Robin and Guze criteria: 1) clinical presentation, 2) associations with para-clinical data such as brain imaging and blood-based biomarkers, 3) delimitation from other disorders, 4) associations with family history / genetics, 5) prognosis and long-term follow-up, and 6) treatment effects. The review highlights that few studies have investigated consequences for the prevalence of the diagnosis of bipolar disorder and for the validity of the diagnosis. Findings from these studies suggest a substantial decrease in the point prevalence of a diagnosis of bipolar with DSM-5 compared with DSM-IV, ranging from 30-50%, but a smaller decrease in the prevalence during lifetime, corresponding to a 6% reduction. It is concluded that it is likely that the use of DSM-5 and ICD-11 will result in diagnostic delay and delayed early intervention in bipolar disorder. Finally, we recommend areas for future research.

Published
2021

22. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Author

Bauer, M, Glenn, T, Achtyes, ED, Alda, M, Agaoglu, E, Altinbas, K, Andreassen, OA, Angelopoulos, E, Ardau, R, Vares, EA, Aydin, M, Ayhan, Y, Baethge, C, Bauer, R, Baune, BT, Balaban, C, Becerra-Palars, C, Behere, AP, Behere, PB, Belete, H, Belete, T, Belizario, GO, Bellivier, F, Belmaker, RH, Benedetti, F, Berk, M, Bersudsky, Y, Bicakci, S, Birabwa-Oketcho, H, Bjella, TD, Brady, C, Cabrera, J, Cappucciati, M, Castro, AMP, Chen, W-L, Cheung, EYW, Chiesa, S, Crowe, M, Cuomo, A, Dallaspezia, S, Del Zompo, M, Desai, P, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fellendorf, FT, Ferensztajn-Rochowiak, E, Fiedorowicz, JG, Fountoulakis, KN, Frye, MA, Geoffroy, PA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Haarman, BCM, Harima, H, Hasse-Sousa, M, Henry, C, Hoffding, L, Houenou, J, Imbesi, M, Isometsa, ET, Ivkovic, M, Janno, S, Johnsen, S, Kapczinski, F, Karakatsoulis, GN, Kardell, M, Kessing, LV, Kim, SJ, Koenig, B, Kot, TL, Koval, M, Kunz, M, Lafer, B, Landen, M, Larsen, ER, Lenger, M, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacKenzie, A, Madsen, HO, Madsen, SAKA, Mahadevan, J, Mahardika, A, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Martiny, K, Mashima, Y, McLoughlin, DM, Meesters, Y, Melle, I, Meza-Urzua, F, Ming, MY, Monteith, S, Moorthy, M, Morken, G, Mosca, E, Mozzhegorov, AA, Munoz, R, Mythri, S, Nacef, F, Nadella, RK, Nakanotani, T, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Ouali, U, Pantovic-Stefanovic, M, Pariwatcharakul, P, Petite, J, Pfennig, A, Ruiz, YP, Pilhatsch, M, Pinna, M, Pompili, M, Porter, R, Quiroz, D, Rabelo-da-Ponte, FD, Ramesar, R, Rasgon, N, Ratta-Apha, W, Ratzenhofer, M, Redahan, M, Reddy, MS, Reif, A, Reininghaus, EZ, Richards, JG, Ritter, P, Rybakowski, JK, Sathyaputri, L, Scippa, AM, Simhandl, C, Severus, E, Smith, D, Smith, J, Stackhouse, PW, Stein, DJ, Stilwell, K, Strejilevich, S, Su, K-P, Subramaniam, M, Sulaiman, AH, Suominen, K, Tanra, AJ, Tatebayashi, Y, Teh, WL, Tondo, L, Torrent, C, Tuinstra, D, Uchida, T, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Yalcinkaya, OK, Young, AH, Zgueb, Y, Whybrow, PC, Bauer, M, Glenn, T, Achtyes, ED, Alda, M, Agaoglu, E, Altinbas, K, Andreassen, OA, Angelopoulos, E, Ardau, R, Vares, EA, Aydin, M, Ayhan, Y, Baethge, C, Bauer, R, Baune, BT, Balaban, C, Becerra-Palars, C, Behere, AP, Behere, PB, Belete, H, Belete, T, Belizario, GO, Bellivier, F, Belmaker, RH, Benedetti, F, Berk, M, Bersudsky, Y, Bicakci, S, Birabwa-Oketcho, H, Bjella, TD, Brady, C, Cabrera, J, Cappucciati, M, Castro, AMP, Chen, W-L, Cheung, EYW, Chiesa, S, Crowe, M, Cuomo, A, Dallaspezia, S, Del Zompo, M, Desai, P, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fellendorf, FT, Ferensztajn-Rochowiak, E, Fiedorowicz, JG, Fountoulakis, KN, Frye, MA, Geoffroy, PA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Haarman, BCM, Harima, H, Hasse-Sousa, M, Henry, C, Hoffding, L, Houenou, J, Imbesi, M, Isometsa, ET, Ivkovic, M, Janno, S, Johnsen, S, Kapczinski, F, Karakatsoulis, GN, Kardell, M, Kessing, LV, Kim, SJ, Koenig, B, Kot, TL, Koval, M, Kunz, M, Lafer, B, Landen, M, Larsen, ER, Lenger, M, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacKenzie, A, Madsen, HO, Madsen, SAKA, Mahadevan, J, Mahardika, A, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Martiny, K, Mashima, Y, McLoughlin, DM, Meesters, Y, Melle, I, Meza-Urzua, F, Ming, MY, Monteith, S, Moorthy, M, Morken, G, Mosca, E, Mozzhegorov, AA, Munoz, R, Mythri, S, Nacef, F, Nadella, RK, Nakanotani, T, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Ouali, U, Pantovic-Stefanovic, M, Pariwatcharakul, P, Petite, J, Pfennig, A, Ruiz, YP, Pilhatsch, M, Pinna, M, Pompili, M, Porter, R, Quiroz, D, Rabelo-da-Ponte, FD, Ramesar, R, Rasgon, N, Ratta-Apha, W, Ratzenhofer, M, Redahan, M, Reddy, MS, Reif, A, Reininghaus, EZ, Richards, JG, Ritter, P, Rybakowski, JK, Sathyaputri, L, Scippa, AM, Simhandl, C, Severus, E, Smith, D, Smith, J, Stackhouse, PW, Stein, DJ, Stilwell, K, Strejilevich, S, Su, K-P, Subramaniam, M, Sulaiman, AH, Suominen, K, Tanra, AJ, Tatebayashi, Y, Teh, WL, Tondo, L, Torrent, C, Tuinstra, D, Uchida, T, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Yalcinkaya, OK, Young, AH, Zgueb, Y, and Whybrow, PC

Abstract

BACKGROUND: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. METHODS: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). RESULTS: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. CONCLUSION: A large change in solar insolation, both between winter and summer and between the minimum an

Published
2021

24. Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action

Author

Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), Andreassen, O.A. (Ole), Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), and Andreassen, O.A. (Ole)

Abstract

Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemin

Published
2020
Full Text
View/download PDF

25. German S3 guidelines on bipolar disorders-first update 2019 What is new in pharmacotherapy?

Author

Bschor, T., Baethge, C., Grunze, H., Lewitzka, U., Scherk, H., Severus, E., Bauer, M., Bschor, T., Baethge, C., Grunze, H., Lewitzka, U., Scherk, H., Severus, E., and Bauer, M.

Abstract

Background German S3 guidelines are subject to the highest methodological standards. This includes that they are only valid for a certain time period. Following the first edition in 2012 the first update of the S3 guidelines on bipolar disorder has now been published (2019). Objective What has changed in the field of pharmacological recommendations comparing the first edition with the update in 2019? Material and methods Comparison of the 1st edition from 2012 with the update from 2019 of the S3 guidelines for the diagnostics and treatment of bipolar disorders. Results The three principle treatment targets of acute treatment of bipolar depression, acute treatment of mania and phase prophylaxis (maintenance treatment) can be distinguished. For acute treatment of bipolar depression, for the first time a medication has received a level A recommendation: quetiapine. For the acute treatment of mania, several drugs are still recommended with the same level of recommendation (B). Asenapine has been added as the tenth substance. Lithium is still the only drug with a level A recommendation for maintenance and prophylactic treatment and is also the only drug approved for this indication without restrictions. A new recommendation is that in the absence of contraindications, phase prophylaxis with a serum level of at least 0.6x202f;mmol/l should be carried out. With a B recommendation, quetiapine has been added to the drugs for phase prophylactic treatment. Conclusion The S3 guidelines make recommendations at the highest scientific level. In view of these findings, lithium is clearly underutilized for maintenance therapy. In the absence of clear contraindications (advanced renal insufficiency), every patient with bipolar disease should be given the chance of lithium prophylaxis for an adequately long period.

Published
2020

26. Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action

Author

Manchia, M, Vieta, E, Smeland, OB, Altimus, C, Bechdolf, A, Bellivier, F, Bergink, Veerle, Fagiolini, A, Geddes, JR, Hajek, T, Henry, C, Kupka, R, Lagerberg, TV, Licht, RW, Martinez-Cengotitabengoa, M, Morken, G, Nielsen, RE, Pinto, AG, Reif, A, Rietschel, M, Ritter, P, Schulze, TG, Scott, J, Severus, E, Yildiz, A, Kessing, LV, Bauer, M, Goodwin, GM, Andreassen, OA, Manchia, M, Vieta, E, Smeland, OB, Altimus, C, Bechdolf, A, Bellivier, F, Bergink, Veerle, Fagiolini, A, Geddes, JR, Hajek, T, Henry, C, Kupka, R, Lagerberg, TV, Licht, RW, Martinez-Cengotitabengoa, M, Morken, G, Nielsen, RE, Pinto, AG, Reif, A, Rietschel, M, Ritter, P, Schulze, TG, Scott, J, Severus, E, Yildiz, A, Kessing, LV, Bauer, M, Goodwin, GM, and Andreassen, OA

Published
2020

30. Association between solar insolation and a history of suicide attempts in bipolar I disorder

Author

Bauer, M. Glenn, T. Alda, M. Andreassen, O.A. Angelopoulos, E. Ardau, R. Ayhan, Y. Baethge, C. Bauer, R. Baune, B.T. Becerra-Palars, C. Bellivier, F. Belmaker, R.H. Berk, M. Bersudsky, Y. Bicakci, Ş. Birabwa-Oketcho, H. Bjella, T.D. Cabrera, J. Wo Cheung, E.Y. Del Zompo, M. Dodd, S. Donix, M. Etain, B. Fagiolini, A. Fountoulakis, K.N. Frye, M.A. Gonzalez-Pinto, A. Gottlieb, J.F. Grof, P. Harima, H. Henry, C. Isometsä, E.T. Janno, S. Kapczinski, F. Kardell, M. Khaldi, S. Kliwicki, S. König, B. Kot, T.L. Krogh, R. Kunz, M. Lafer, B. Landén, M. Larsen, E.R. Lewitzka, U. Licht, R.W. Lopez-Jaramillo, C. MacQueen, G. Manchia, M. Marsh, W. Martinez-Cengotitabengoa, M. Melle, I. Meza-Urzúa, F. Ming, M.Y. Monteith, S. Morken, G. Mosca, E. Mozzhegorov, A.A. Munoz, R. Mythri, S.V. Nacef, F. Nadella, R.K. Nery, F.G. Nielsen, R.E. O'Donovan, C. Omrani, A. Osher, Y. Sørensen, H.Ø. Ouali, U. Ruiz, Y.P. Pilhatsch, M. Pinna, M. da Ponte, F.D.R. Quiroz, D. Ramesar, R. Rasgon, N. Reddy, M.S. Reif, A. Ritter, P. Rybakowski, J.K. Sagduyu, K. Raghuraman, B.S. Scippa, Â.M. Severus, E. Simhandl, C. Stackhouse, P.W., Jr. Stein, D.J. Strejilevich, S. Subramaniam, M. Sulaiman, A.H. Suominen, K. Tagata, H. Tatebayashi, Y. Tondo, L. Torrent, C. Vaaler, A.E. Vares, E. Veeh, J. Vieta, E. Viswanath, B. Yoldi-Negrete, M. Zetin, M. Zgueb, Y. Whybrow, P.C.

Abstract

In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres. Suicide related data were available for 3365 patients from 310 onset locations in 51 countries. 1047 (31.1%) had a history of suicide attempt. There was a significant inverse association between a history of suicide attempt and the ratio of mean winter solar insolation/mean summer solar insolation. This ratio is smallest near the poles where the winter insolation is very small compared to the summer insolation. This ratio is largest near the equator where there is relatively little variation in the insolation over the year. Other variables in the model that were positively associated with suicide attempt were being female, a history of alcohol or substance abuse, and being in a younger birth cohort. Living in a country with a state-sponsored religion decreased the association. (All estimated coefficients p < 0.01). In summary, living in locations with large changes in solar insolation between winter and summer may be associated with increased suicide attempts in patients with bipolar disorder. Further investigation of the impacts of solar insolation on the course of bipolar disorder is needed. © 2019 Elsevier Ltd

Published
2019

33. What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium

Author

Nolen, WA, Licht, RW, Young, AH, Malhi, GS, Tohen, M, Vieta, E, Kupka, RW, Zarate, C, Nielsen, RE, Baldessarini, RJ, Severus, E, Alda, M, Bauer, M, Berghoefer, A, Berk, M, Bocchetta, A, Calkin, CV, Duffy, A, Fountoulakis, KN, Gonzalez-Pinto, A, Hajek, T, Kessing, LV, Lopez-Jaramillo, C, Machado-Vieira, R, Post, RM, Rybakowski, JK, Simhandl, C, Soares, JC, Tondo, L, Nolen, WA, Licht, RW, Young, AH, Malhi, GS, Tohen, M, Vieta, E, Kupka, RW, Zarate, C, Nielsen, RE, Baldessarini, RJ, Severus, E, Alda, M, Bauer, M, Berghoefer, A, Berk, M, Bocchetta, A, Calkin, CV, Duffy, A, Fountoulakis, KN, Gonzalez-Pinto, A, Hajek, T, Kessing, LV, Lopez-Jaramillo, C, Machado-Vieira, R, Post, RM, Rybakowski, JK, Simhandl, C, Soares, JC, and Tondo, L

Abstract

AIMS: To systematically review the existing trials on optimal serum levels for lithium for maintenance treatment of bipolar disorder and to develop clinical recommendations. METHODS: Systematic literature search. Discussion of major characteristics, limitations, methodological quality, and results of selected trials. Delphi survey consisting of clinical questions and corresponding statements. For statements endorsed by at least 80% of the members, consensus was considered as having been achieved. RESULTS: With strict inclusion criteria no studies could be selected, making it difficult to formulate evidence-based recommendations. After loosening the inclusion criteria 7 trials were selected addressing our aims at least to some extent. Four of these studies suggest better efficacy being associated with lithium serum levels in a range above a lower threshold around 0.45/0.60 and up to 0.80/1.00 mmol/L. These findings support the outcome of the Delphi survey. CONCLUSIONS: For adults with bipolar disorder there was consensus that the standard lithium serum level should be 0.60-0.80 mmol/L with the option to reduce it to 0.40-0.60 mmol/L in case of good response but poor tolerance or to increase it to 0.80-1.00 mmol/L in case of insufficient response and good tolerance. For children and adolescents there was no consensus, but the majority of the members endorsed the same recommendation. For the elderly there was also no consensus, but the majority of the members endorsed a more conservative approach: usually 0.40-0.60 mmol/L, with the option to go to maximally 0.70 or 0.80 mmol/L at ages 65-79 years, and to maximally 0.70 mmol/L over age 80 years.

Published
2019

34. Solar insolation in springtime influences age of onset of bipolar I disorder

Author

Bauer, M. Glenn, T. Alda, M. Aleksandrovich, M.A. Andreassen, O.A. Angelopoulos, E. Ardau, R. Ayhan, Y. Baethge, C. Bharathram, S.R. Bauer, R. Baune, B.T. Becerra-Palars, C. Bellivier, F. Belmaker, R.H. Berk, M. Bersudsky, Y. Bicakci, Ş. Birabwa-Oketcho, H. Bjella, T.D. Bossini, L. Cabrera, J. Cheung, E.Y.W. Del Zompo, M. Dodd, S. Donix, M. Etain, B. Fagiolini, A. Fountoulakis, K.N. Frye, M.A. Gonzalez-Pinto, A. Gottlieb, J.F. Grof, P. Harima, H. Henry, C. Isometsä, E.T. Janno, S. Kapczinski, F. Kardell, M. Khaldi, S. Kliwicki, S. König, B. Kot, T.L. Krogh, R. Kunz, M. Lafer, B. Landén, M. Larsen, E.R. Lewitzka, U. Licht, R.W. Lopez-Jaramillo, C. MacQueen, G. Manchia, M. Marsh, W. Martinez-Cengotitabengoa, M. Melle, I. Meza-Urzúa, F. Yee Ming, M. Monteith, S. Morken, G. Mosca, E. Munoz, R. Mythri, S.V. Nacef, F. Nadella, R.K. Nery, F.G. Nielsen, R.E. O'Donovan, C. Omrani, A. Osher, Y. Østermark Sørensen, H. Ouali, U. Pica Ruiz, Y. Pilhatsch, M. Pinna, M. da Ponte, F.D.R. Quiroz, D. Ramesar, R. Rasgon, N. Reddy, M.S. Reif, A. Ritter, P. Rybakowski, J.K. Sagduyu, K. Scippa, Â.M. Severus, E. Simhandl, C. Stein, D.J. Strejilevich, S. Subramaniam, M. Sulaiman, A.H. Suominen, K. Tagata, H. Tatebayashi, Y. Tondo, L. Torrent, C. Vaaler, A.E. Veeh, J. Vieta, E. Viswanath, B. Yoldi-Negrete, M. Zetin, M. Zgueb, Y. Whybrow, P.C.

Abstract

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Published
2017

35. Solar insolation in springtime influences age of onset of bipolar I disorder

Author

Bauer, M, Glenn, T, Alda, M, Aleksandrovich, MA, Andreassen, OA, Angelopoulos, E, Ardau, R, Ayhan, Y, Baethge, C, Bharathram, SR, Bauer, R, Baune, BT, Becerra-Palars, C, Bellivier, F, Belmaker, RH, Berk, M, Bersudsky, Y, Bicakci, S, Birabwa-Oketcho, H, Bjella, TD, Bossini, L, Cabrera, J, Cheung, EYW, Del Zompo, M, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fountoulakis, KN, Frye, MA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Harima, H, Henry, C, Isometsae, ET, Janno, S, Kapczinski, F, Kardell, M, Khaldi, S, Kliwicki, S, Koenig, B, Kot, TL, Krogh, R, Kunz, M, Lafer, B, Landen, M, Larsen, ER, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Meza-Urzua, F, Yee Ming, M, Monteith, S, Morken, G, Mosca, E, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nery, FG, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Ostermark Sorensen, H, Ouali, U, Pica Ruiz, Y, Pilhatsch, M, Pinna, M, da Ponte, FDR, Quiroz, D, Ramesar, R, Rasgon, N, Reddy, MS, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, AM, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Subramaniam, M, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Tondo, L, Torrent, C, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Zetin, M, Zgueb, Y, Whybrow, PC, Bauer, M, Glenn, T, Alda, M, Aleksandrovich, MA, Andreassen, OA, Angelopoulos, E, Ardau, R, Ayhan, Y, Baethge, C, Bharathram, SR, Bauer, R, Baune, BT, Becerra-Palars, C, Bellivier, F, Belmaker, RH, Berk, M, Bersudsky, Y, Bicakci, S, Birabwa-Oketcho, H, Bjella, TD, Bossini, L, Cabrera, J, Cheung, EYW, Del Zompo, M, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fountoulakis, KN, Frye, MA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Harima, H, Henry, C, Isometsae, ET, Janno, S, Kapczinski, F, Kardell, M, Khaldi, S, Kliwicki, S, Koenig, B, Kot, TL, Krogh, R, Kunz, M, Lafer, B, Landen, M, Larsen, ER, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Meza-Urzua, F, Yee Ming, M, Monteith, S, Morken, G, Mosca, E, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nery, FG, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Ostermark Sorensen, H, Ouali, U, Pica Ruiz, Y, Pilhatsch, M, Pinna, M, da Ponte, FDR, Quiroz, D, Ramesar, R, Rasgon, N, Reddy, MS, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, AM, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Subramaniam, M, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Tondo, L, Torrent, C, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Zetin, M, Zgueb, Y, and Whybrow, PC

Abstract

OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

Published
2017

36. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Author

Bauer, M. Glenn, T. Alda, M. Andreassen, O. A. and Angelopoulos, E. Ardau, R. Baethge, C. Bauer, R. and Bellivier, F. Belmaker, R. H. Berk, M. Bjella, T. D. and Bossini, L. Bersudsky, Y. Cheung, E. Y. W. Conell, J. and Del Zompo, M. Dodd, S. Etain, B. Fagiolini, A. Frye, M. A. Fountoulakis, K. N. Garneau-Fournier, J. Gonzalez-Pinto, A. Harima, H. Hassel, S. Henry, C. Iacovides, A. and Isometsa, E. T. Kapczinski, F. Kliwicki, S. Koenig, B. and Krogh, R. Kunz, M. Lafer, B. Larsen, E. R. Lewitzka, U. and Lopez-Jaramillo, C. MacQueen, G. Manchia, M. Marsh, W. and Martinez-Cengotitabengoa, M. Melle, I. Monteith, S. and Morken, G. Munoz, R. Nery, F. G. O'Donovan, C. Osher, Y. and Pfennig, A. Quiroz, D. Ramesar, R. Rasgon, N. Reif, A. Ritter, P. Rybakowski, J. K. Sagduyu, K. Scippa, A. M. Severus, E. Simhandl, C. Stein, D. J. Strejilevich, S. Sulaiman, A. Hatim Suominen, K. Tagata, H. and Tatebayashi, Y. Torrent, C. Vieta, E. Viswanath, B. and Wanchoo, M. J. Zetin, M. Whybrow, P. C.

Abstract

Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data using the residuals. Clinical variables in subgroups were compared. Results: There was a strong birth cohort effect. Without adjusting for the birth cohort, three subgroups were found by clustering. After adjusting for the birth cohort or when considering only those born after 1959, two subgroups were found. With results of either two or three subgroups, the youngest subgroup was more likely to have a family history of mood disorders and a first episode with depressed polarity. However, without adjusting for birth cohort (three subgroups), family history and polarity of the first episode could not be distinguished between the middle and oldest subgroups. Conclusion: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research. (C) 2014 Elsevier Masson SAS. All rights reserved.

Published
2015

39. Does lithium reduce acute suicidal ideation and behavior? A protocol for a randomized, placebo-controlled multicenter trial of lithium plus Treatment As Usual (TAU) in patients with suicidal major depressive episode

Author

Lewitzka, U., primary, Jabs, B., additional, Fülle, M., additional, Holthoff, V., additional, Juckel, G., additional, Uhl, I., additional, Kittel-Schneider, S., additional, Reif, A., additional, Reif-Leonhard, C., additional, Gruber, O., additional, Djawid, B., additional, Goodday, S., additional, Haussmann, R., additional, Pfennig, A., additional, Ritter, P., additional, Conell, J., additional, Severus, E., additional, and Bauer, M., additional

Published
2015
Full Text
View/download PDF

40. Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study

Author

Bauer, M, Glenn, T, Alda, M, Andreassen, OA, Angelopoulos, E, Ardau, R, Baethge, C, Bauer, R, Bellivier, F, Belmaker, RH, Berk, M, Bjella, TD, Bossini, L, Bersudsky, Y, Cheung, EYW, Conell, J, Del Zompo, M, Dodd, S, Etain, B, Fagiolini, A, Frye, MA, Fountoulakis, KN, Garneau-Fournier, J, Gonzalez-Pinto, A, Harima, H, Hassel, S, Henry, C, Iacovides, A, Isometsa, ET, Kapczinski, F, Kliwicki, S, Koenig, B, Krogh, R, Kunz, M, Lafer, B, Larsen, ER, Lewitzka, U, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Monteith, S, Morken, G, Munoz, R, Nery, FG, O'Donovan, C, Osher, Y, Pfennig, A, Quiroz, D, Ramesar, R, Rasgon, N, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, AM, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Torrent, C, Vieta, E, Viswanath, B, Wanchoo, MJ, Zetin, M, Whybrow, PC, Bauer, M, Glenn, T, Alda, M, Andreassen, OA, Angelopoulos, E, Ardau, R, Baethge, C, Bauer, R, Bellivier, F, Belmaker, RH, Berk, M, Bjella, TD, Bossini, L, Bersudsky, Y, Cheung, EYW, Conell, J, Del Zompo, M, Dodd, S, Etain, B, Fagiolini, A, Frye, MA, Fountoulakis, KN, Garneau-Fournier, J, Gonzalez-Pinto, A, Harima, H, Hassel, S, Henry, C, Iacovides, A, Isometsa, ET, Kapczinski, F, Kliwicki, S, Koenig, B, Krogh, R, Kunz, M, Lafer, B, Larsen, ER, Lewitzka, U, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Monteith, S, Morken, G, Munoz, R, Nery, FG, O'Donovan, C, Osher, Y, Pfennig, A, Quiroz, D, Ramesar, R, Rasgon, N, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, AM, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Torrent, C, Vieta, E, Viswanath, B, Wanchoo, MJ, Zetin, M, and Whybrow, PC

Abstract

BACKGROUND: The onset of bipolar disorder is influenced by the interaction of genetic and environmental factors. We previously found that a large increase in sunlight in springtime was associated with a lower age of onset. This study extends this analysis with more collection sites at diverse locations, and includes family history and polarity of first episode. METHODS: Data from 4037 patients with bipolar I disorder were collected at 36 collection sites in 23 countries at latitudes spanning 3.2 north (N) to 63.4 N and 38.2 south (S) of the equator. The age of onset of the first episode, onset location, family history of mood disorders, and polarity of first episode were obtained retrospectively, from patient records and/or direct interview. Solar insolation data were obtained for the onset locations. RESULTS: There was a large, significant inverse relationship between maximum monthly increase in solar insolation and age of onset, controlling for the country median age and the birth cohort. The effect was reduced by half if there was no family history. The maximum monthly increase in solar insolation occurred in springtime. The effect was one-third smaller for initial episodes of mania than depression. The largest maximum monthly increase in solar insolation occurred in northern latitudes such as Oslo, Norway, and warm and dry areas such as Los Angeles, California. LIMITATIONS: Recall bias for onset and family history data. CONCLUSIONS: A large springtime increase in sunlight may have an important influence on the onset of bipolar disorder, especially in those with a family history of mood disorders.

Published
2014

42. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders

Author

Bauer, M, Pfennig, A, Severus, E, Whybrow, PC, Angst, J, Möller, HJ, Adli, M, Benkert, O, Bschor, T, Tadić, A, Holsboer-Trachsler, E, Anderson, I, Baldwin, D, Cookson, JC, Grunze, H, Katona, C, Paykel, ES, Tylee, A, Ayuso-Gutierrez, JL, Vieta, E, Bech, P, Licht, RW, Lublin, H, Vestergaard, P, Berk, M, Burrows, G, Mitchell, PB, Schweitzer, I, Bitter, I, Cassano, G, Cetkovich-Bakmas, M, Da Costa, D, Gheorghe, MD, Heinze, G, Higuchi, T, Hirschfeld, RMA, Keller, MB, Kupfer, DJ, Rush, AJ, Unützer, J, Höschl, C, Kang, RH, Lee, MS, Lim, SW, Paik, JW, Park, YC, Kasper, S, Kirli, S, Yazici, A, Kostukova, E, Kulhara, P, Leonard, B, Lingjaerde, O, Liu, CY, Mendlewicz, J, Puzynski, S, Rybakowski, JK, Yamada, K, Bauer, M, Pfennig, A, Severus, E, Whybrow, PC, Angst, J, Möller, HJ, Adli, M, Benkert, O, Bschor, T, Tadić, A, Holsboer-Trachsler, E, Anderson, I, Baldwin, D, Cookson, JC, Grunze, H, Katona, C, Paykel, ES, Tylee, A, Ayuso-Gutierrez, JL, Vieta, E, Bech, P, Licht, RW, Lublin, H, Vestergaard, P, Berk, M, Burrows, G, Mitchell, PB, Schweitzer, I, Bitter, I, Cassano, G, Cetkovich-Bakmas, M, Da Costa, D, Gheorghe, MD, Heinze, G, Higuchi, T, Hirschfeld, RMA, Keller, MB, Kupfer, DJ, Rush, AJ, Unützer, J, Höschl, C, Kang, RH, Lee, MS, Lim, SW, Paik, JW, Park, YC, Kasper, S, Kirli, S, Yazici, A, Kostukova, E, Kulhara, P, Leonard, B, Lingjaerde, O, Liu, CY, Mendlewicz, J, Puzynski, S, Rybakowski, JK, and Yamada, K

Abstract

Objectives. This 2013 update of the practice guidelines for the biological treatment of unipolar depressive disorders was developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal has been to systematically review all available evidence pertaining to the treatment of unipolar depressive disorders, and to produce a series of practice recommendations that are clinically and scientifically meaningful based on the available evidence. The guidelines are intended for use by all physicians seeing and treating patients with these conditions. Methods. The 2013 update was conducted by a systematic update literature search and appraisal. All recommendations were approved by the Guidelines Task Force. Results. This first part of the guidelines (Part 1) covers disease definition, classification, epidemiology, and course of unipolar depressive disorders, as well as the management of the acute and continuation phase treatment. It is primarily concerned with the biological treatment (including antidepressants, other psychopharmacological medications, electroconvulsive therapy, light therapy, adjunctive and novel therapeutic strategies) of adults. Conclusions. To date, there is a variety of evidence-based antidepressant treatment options available. Nevertheless there is still a substantial proportion of patients not achieving full remission. In addition, somatic and psychiatric comorbidities and other special circumstances need to be more thoroughly investigated. Therefore, further high-quality informative randomized controlled trials are urgently needed. © 2013 Informa Healthcare.

Published
2013

43. Antidepressant dosage taken by patients with bipolar disorder: factors associated with irregularity

Author

Bauer, R, Glenn, T, Alda, M, Sagduyu, K, Marsh, W, Grof, P, Munoz, R, Murray, G, Ritter, P, Lewitzka, U, Severus, E, Whybrow, PC, Bauer, M, Bauer, R, Glenn, T, Alda, M, Sagduyu, K, Marsh, W, Grof, P, Munoz, R, Murray, G, Ritter, P, Lewitzka, U, Severus, E, Whybrow, PC, and Bauer, M

Abstract

BACKGROUND: This study analyzed regularity in the daily dosage of antidepressants taken by patients with bipolar disorder and identified the factors associated with irregularity. METHODS: Daily self-reported medication dosage taken and mood ratings were available from 144 patients who received treatment as usual. All 144 patients took the same antidepressant for at least 100 days. One hundred eleven of these patients were also taking a mood stabilizer. Approximate entropy (ApEn) was used to measure serial regularity in daily dosage. Regularity is the tendency that values within a time series remain the same on incremental comparisons. Drug holidays (missing three or more consecutive days) were also determined. Generalized estimating equations (GEE) were used to estimate if any demographic or clinical variables were associated with regularity. RESULTS: Although the mean percent of days missing doses was only 18.6%, there was a wide range of regularity in the daily antidepressant dosage. Drug holidays were common, occurring in 41% of the analyses. Factors significantly associated with irregularity were as follows: total number of psychotropic medications (p = 0.005), pill burden (p = 0.005), and depression (p = 0.015). Neither the percent of days missing doses nor the drug holidays were associated with any demographic or clinical factors. For patients taking both antidepressants and mood stabilizers, there was no significant difference in regularity in daily dosage between these drugs. DISCUSSION: There can be considerable irregularity in daily dosage despite a low percent of days missing doses. Medication regimen complexity and depressed mood are associated with increased irregularity. Daily regularity in drug dosage may be more dependent on the individual than on the specific drug. Research on the clinical impact of irregularity in daily dosage of antidepressants is needed.

Published
2013

46. Bipolare Depression

Author

Seemüller, F., primary, Riedel, M., additional, Dargel, S., additional, Djaja, N., additional, Schennach-Wolff, R., additional, Dittmann, S., additional, Möller, H.-J., additional, and Severus, E., additional

Published
2010
Full Text
View/download PDF

49. Effect of Aripiprazole on Cognition in the Treatment of Patients with Schizophrenia

Author

Riedel, M., primary, Spellmann, I., additional, Schennach-Wolff, R., additional, Musil, R., additional, Dehning, S., additional, Cerovecki, A., additional, Opgen-Rhein, M., additional, Matz, J., additional, Seemüller, F., additional, Obermeier, M., additional, Severus, E., additional, Engel, R. R., additional, Müller, N., additional, and Möller, H.-J., additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results