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460 results on '"Severson, David W."'

4. Demonstration of RNAi Yeast Insecticide Activity in Semi-Field Larvicide and Attractive Targeted Sugar Bait Trials Conducted on Aedes and Culex Mosquitoes

Author

Stewart, Akilah T. M., primary, Mysore, Keshava, additional, Njoroge, Teresia M., additional, Winter, Nikhella, additional, Feng, Rachel Shui, additional, Singh, Satish, additional, James, Lester D., additional, Singkhaimuk, Preeraya, additional, Sun, Longhua, additional, Mohammed, Azad, additional, Oxley, James D., additional, Duckham, Craig, additional, Ponlawat, Alongkot, additional, Severson, David W., additional, and Duman-Scheel, Molly, additional

Published
2023
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10. Marker-assisted mapping enables forward genetic analysis in Aedes aegypti, an arboviral vector with vast recombination deserts

Author

Chen, Chujia, primary, Compton, Austin, additional, Nikolouli, Katerina, additional, Wang, Aihua, additional, Aryan, Azadeh, additional, Sharma, Atashi, additional, Qi, Yumin, additional, Dellinger, Camden, additional, Hempel, Melanie, additional, Potters, Mark, additional, Augustinos, Antonios, additional, Severson, David W, additional, Bourtzis, Kostas, additional, and Tu, Zhijian, additional

Published
2022
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11. Correction: Mysore et al. A Broad-Based Mosquito Yeast Interfering RNA Pesticide Targeting Rbfox1 Represses Notch Signaling and Kills Both Larvae and Adult Mosquitoes. Pathogens 2021, 10, 1251

Author

Mysore, Keshava, primary, Sun, Longhua, additional, Hapairai, Limb K., additional, Wang, Chien-Wei, additional, Roethele, Joseph B., additional, Igiede, Jessica, additional, Scheel, Max P., additional, Scheel, Nicholas D., additional, Li, Ping, additional, Wei, Na, additional, Severson, David W., additional, and Duman-Scheel, Molly, additional

Published
2022
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18. Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Author

Arensburger, Peter, Megy, Karine, Waterhouse, Robert M., Abrudan, Jenica, Amedeo, Paolo, Antelo, Beatriz, Bartholomay, Lyric, Bidwell, Shelby, Caler, Elisabet, Camara, Francisco, Campbell, Corey L., Campbell, Kathryn S., Casola, Claudio, Castro, Marta T., Chandramouliswaran, Ishwar, Chapman, Sinéad B., Christley, Scott, Costas, Javier, Eisenstadt, Eric, Feschotte, Cedric, Fraser-Liggett, Claire, Guigo, Roderic, Haas, Brian, Hammond, Martin, Hansson, Bill S., Hemingway, Janet, Hill, Sharon R., Howarth, Clint, Ignell, Rickard, Kennedy, Ryan C., Kodira, Chinnappa D., Lobo, Neil F., Mao, Chunhong, Mayhew, George, Michel, Kristin, Mori, Akio, Liu, Nannan, Naveira, Horado, Nene, Vishvanath, Nguyen, Nam, Pearson, Matthew D., Pritham, Ellen J., Puiu, Daniela, Qi, Yumin, Ranson, Hilary, Ribeiro, Jose M. C., Roberston, Hugh M., Severson, David W., Shumway, Martin, Stanke, Mario, Strausberg, Robert L., Sun, Cheng, Sutton, Granger, Tubio, Jose Manuel C., Unger, Maria F., Vanlandingham, Dana L., Vilella, Albert J., White, Owen, White, Jared R., Wondji, Charles S., Wortman, Jennifer, Zdobnov, Evgeny M., Birren, Bruce, Christensen, Bruce M., Collins, Frank H., Cornel, Anthony, Dimopoulos, George, Hannick, Linda I., Higgs, Stephen, Lanzaro, Gregory C., Lawson, Daniel, Lee, Norman H., Muskavitch, Marc A. T., Raikhel, Alexander S., and Atkinson, Peter W.

Published
2010

20. Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes

Author

Waterhouse, Robert M., Kriventseva, Evgenia V., Meister, Stephan, Xi, Zhiyong, Alvarez, Kanwal S., Bartholomay, Lyric C., Barillas-Mury, Carolina, Bian, Guowu, Blandin, Stephanie, Christensen, Bruce M., Dong, Yuemei, Jiang, Haobo, Kanost, Michael R., Koutsos, Anastasios C., Levashina, Elena A., Li, Jianyong, Ligoxygakis, Petros, MacCallum, Robert M., Mayhew, George F., Mendes, Antonio, Michel, Kristin, Osta, Mike A., Paskewitz, Susan, Shin, Sang Woon, Vlachou, Dina, Wang, Lihui, Wei, Weiqi, Zheng, Liangbiao, Zou, Zhen, Severson, David W., Raikhel, Alexander S., Kafatos, Fotis C., Dimopoulos, George, Zdobnov, Evgeny M., and Christophides, George K.

Published
2007
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21. Genome Sequence of Aedes aegypti, a Major Arbovirus Vector

Author

Nene, Vishvanath, Wortman, Jennifer R., Lawson, Daniel, Haas, Brian, Kodira, Chinnappa, Tu, Zhijian (Jake), Loftus, Brendan, Xi, Zhiyong, Megy, Karyn, Grabherr, Manfred, Ren, Quinghu, Zdobnov, Evgeny M., Lobo, Neil F., Campbell, Kathryn S., Brown, Susan E., Bonaldo, Maria F., Zhu, Jingsong, Sinkins, Steven P., Hogenkamp, David G., Amedeo, Paolo, Arensburger, Peter, Atkinson, Peter W., Bidwell, Shelby, Biedler, Jim, Birney, Ewan, Bruggner, Robert V., Costas, Javier, Coy, Monique R., Crabtree, Jonathan, Crawford, Matt, deBruyn, Becky, DeCaprio, David, Eiglmeier, Karin, Eisenstadt, Eric, El-Dorry, Hamza, Gelbart, William M., Gomes, Suely L., Hammond, Martin, Hannick, Linda I., Hogan, James R., Holmes, Michael H., Jaffe, David, Johnston, J. Spencer, Kennedy, Ryan C., Koo, Hean, Kravitz, Saul, Kriventseva, Evgenia V., Kulp, David, LaButti, Kurt, Lee, Eduardo, Li, Song, Lovin, Diane D., Mao, Chunhong, Mauceli, Evan, Menck, Carlos F. M., Miller, Jason R., Montgomery, Philip, Mori, Akio, Nascimento, Ana L., Naveira, Horacio F., Nusbaum, Chad, O'Leary, Sinéad, Orvis, Joshua, Pertea, Mihaela, Quesneville, Hadi, Reidenbach, Kyanne R., Rogers, Yu-Hui, Roth, Charles W., Schneider, Jennifer R., Schatz, Michael, Shumway, Martin, Stanke, Mario, Stinson, Eric O., Tubio, Jose M. C., VanZee, Janice P., Verjovski-Almeida, Sergio, Werner, Doreen, White, Owen, Wyder, Stefan, Zeng, Qiandong, Zhao, Qi, Zhao, Yongmei, Hill, Catherine A., Raikhel, Alexander S., Soares, Marcelo B., Knudson, Dennis L., Lee, Norman H., Galagan, James, Salzberg, Steven L., Paulsen, Ian T., Dimopoulos, George, Collins, Frank H., Birren, Bruce, Fraser-Liggett, Claire M., and Severson, David W.

Published
2007
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22. A Yeast RNA-Interference Pesticide Targeting the Irx Gene Functions as a Broad-Based Mosquito Larvicide and Adulticide

Author

Mysore, Keshava, primary, Sun, Longhua, additional, Hapairai, Limb K., additional, Wang, Chien-Wei, additional, Igiede, Jessica, additional, Roethele, Joseph B., additional, Scheel, Nicholas D., additional, Scheel, Max P., additional, Li, Ping, additional, Wei, Na, additional, Severson, David W., additional, and Duman-Scheel, Molly, additional

Published
2021
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24. A Broad-Based Mosquito Yeast Interfering RNA Pesticide Targeting Rbfox1 Represses Notch Signaling and Kills Both Larvae and Adult Mosquitoes

Author

Mysore, Keshava, primary, Sun, Longhua, additional, Hapairai, Limb K., additional, Wang, Chien-Wei, additional, Roethele, Joseph B., additional, Igiede, Jessica, additional, Scheel, Max P., additional, Scheel, Nicholas D., additional, Li, Ping, additional, Wei, Na, additional, Severson, David W., additional, and Duman-Scheel, Molly, additional

Published
2021
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29. Marker-assisted mapping enables effective forward genetic analysis in the arboviral vector Aedes aegypti, a species with vast recombination deserts

Author

Chen, Chujia, primary, Compton, Austin, additional, Nikolouli, Katerina, additional, Wang, Aihua, additional, Aryan, Azadeh, additional, Sharma, Atashi, additional, Qi, Yumin, additional, Delinger, Camden, additional, Hempel, Melanie, additional, Augustinos, Antonios, additional, Severson, David W., additional, Bourtzis, Kostas, additional, and Tu, Zhijian, additional

Published
2021
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32. Quantitative genetics of vector competence for La Crosse virus and body size in Ochlerotatus hendersoni and Ochlerotatus triseriatus interspecific hybrids

Author

Anderson, Justin R., Schneider, Jennifer R., Grimstad, Paul R., and Severson, David W.

Subjects
Quantitative trait loci -- Research, Encephalitis -- Causes of, Genetic research, Biological sciences
Abstract

La Crosse virus is a leading cause of pediatric encephalitis in the United States. The mosquito Ochlerotatus triseriatus is an efficient vector for La Crosse virus, whereas the closely related O. hendersoni transmits only at very low rates. Quantitative trait loci (QTL) affecting the ability to orally transmit this virus and adult body size were identified in 164 [F.sub.2] female individuals from interspecific crosses of O. hendersoni females and O. triseriatus males using a combination of composite interval mapping (CIM), interval mapping (IM) for binary traits, and single-marker mapping. For oral transmission (OT), no genome locations exceeded the 95% experimentwise threshold for declaring a QTL using IM, but single-marker analysis identified four independent regions significantly associated with OT that we considered as tentative QTL. With two QTL, an increase in OT was associated with alleles from the refractory vector, O. hendersoni, and likely reflect epistatic interactions between genes that were uncovered by our interspecific crosses. For body size, two QTL were identified using CIM and a third tentative QTL was identified using single-marker analysis. The genome regions associated with body size also contain three QTL controlling OT, suggesting that these regions contain either single genes with pleiotropic effects or multiple linked genes independently determining each trait.

Published
2005

35. Quantitative Trait Locus Determining the Time of Blood Feeding in Culex pipiens(Diptera: Culicidae)

Author

Hickner, Paul V, Mori, Akio, Rund, Samuel S C, and Severson, David W

Abstract

Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as Plasmodiumspp. (malaria), Wuchereria bancrofti(lymphatic filariasis), Borrelia burgdorferi(Lyme disease), and viruses causing dengue, Zika, West Nile, chikungunya, and yellow fever. Among the most effective strategies for the prevention of vector-borne diseases are those aimed at reducing human–vector interactions, such as insecticide applications and insecticide-treated bed nets (ITNs). In some areas where ITNs are widely used, behavioral adaptations have resulted in mosquitoes shifting their time of blood feeding to earlier or later in the night when the bed nets are not being employed. Little is known about the genetic basis of these behavioral shifts. We conducted quantitative trait locus (QTL) analysis using two strains of Culex pipienssensu lato with contrasting blood feeding behaviors, wherein the lab adapted Shasta strain blood feeds at any time of the day or night, while the newly established Trinidad strain feeds only at night. We identified a single locus on chromosome 2 associated with the observed variation in feeding times. None of the core clock genes period, timeless, clock, cycle, PAR-domain protein 1, vrille, discs overgrown, cryptochrome 1, or cryptochrome 2were located within the QTL region. We then monitored locomotor behavior to determine if they differed in their flight activity. The highly nocturnal Trinidad strain showed little daytime activity while the day-feeding Shasta strain was active during the day, suggesting blood feeding behavior and flight activity are physiologically linked.

Published
2022
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36. Dynamics of molecular markers linked to the resistance loci in a Mosquito-Plasmodium System

Author

Yan, Guiyun and Severson, David W.

Subjects
Malaria -- Genetic aspects, Mosquitoes -- Genetic aspects, Yellow fever -- Genetic aspects, Biological sciences
Abstract

Models on the evolution of resistance to parasitism generally assume fitness tradeoffs between the costs of being parasitized and the costs associated with resistance. This study tested this assumption using the yellow fever mosquito Aedes aegypti and malaria parasite Plasmodium gallinaceum system. Experimental mosquito populations were created by mixing susceptible and resistant strains in equal proportions, and then the dynamics of markers linked to loci for Plasmodium resistance and other unlinked neutral markers were determined over 12 generations. We found that when the mixed population was maintained under parasite-free conditions, the frequencies of alleles specific to the susceptible strain at markers closely linked to the loci for resistance (QTL markers) as well as other unlinked markers increased significantly in the first generation and then fluctuated around equilibrium frequencies for all six markers. However, when the mixed population was exposed to an infected blood meal every generation, allele frequencies at the QTL markers for resistance were not significantly changed. Small population size caused significant random fluctuations of allele frequencies at all marker loci. Consistent allele frequency changes in the QTL markers and other unlinked markers suggest that the reduced fitness in the resistant population has a genome-wide effect on the genetic makeup of the mixed population. Continuous exposure to parasites promoted the maintenance of alleles from the resistant Moyo-R strain in the 'mixed population. The results are discussed in relation to the proposed malaria control strategy through genetic disruption of vector competence.

Published
2003

40. Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes

Author

Mysore, Keshava, primary, Hapairai, Limb K., additional, Sun, Longhua, additional, Li, Ping, additional, Wang, Chien-Wei, additional, Scheel, Nicholas D., additional, Lesnik, Alexandra, additional, Igiede, Jessica, additional, Scheel, Max P., additional, Wei, Na, additional, Severson, David W., additional, and Duman-Scheel, Molly, additional

Published
2020
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43. VectorBase: a data resource for invertebrate vector genomics

Author

Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J., Bruggner, Robert V., Butler, Ryan, Campbell, Kathryn S., Christophides, George K., Christley, Scott, Dialynas, Emmanuel, Hammond, Martin, Hill, Catherine A., Konopinski, Nathan, Lobo, Neil F., MacCallum, Robert M., Madey, Greg, Megy, Karine, Meyer, Jason, Redmond, Seth, Severson, David W., Stinson, Eric O., Topalis, Pantelis, Birney, Ewan, Gelbart, William M., Kafatos, Fotis C., Louis, Christos, and Collins, Frank H.

Published
2009

45. VectorBase: a home for invertebrate vectors of human pathogens

Author

Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J., Bruggner, Robert V., Butler, Ryan, Campbell, Kathryn S., Christophides, George K., Christley, Scott, Dialynas, Emmanuel, Emmert, David, Hammond, Martin, Hill, Catherine A., Kennedy, Ryan C., Lobo, Neil F., MacCallum, M. Robert, Madey, Greg, Megy, Karine, Redmond, Seth, Russo, Susan, Severson, David W., Stinson, Eric O., Topalis, Pantelis, Zdobnov, Evgeny M., Birney, Ewan, Gelbart, William M., Kafatos, Fotis C., Louis, Christos, and Collins, Frank H.

Published
2007

46. Evidence for genetic hitchhiking effect associated with insecticide resistance in Aedes aegypti

Author

Yan, Guiyun, Chadee, Dave D., and Severson, David W.

Subjects
Aedes -- Genetic aspects, Insecticide resistance -- Genetic aspects, Variation (Biology) -- Research, Mosquitoes -- Genetic aspects, Biological sciences
Abstract

Information on genetic variation within and between populations is critical for understanding the evolutionary history of mosquito populations and disease epidemiology. Previous studies with Drosophila suggest that genetic variation of selectively neutral loci in a large fraction of genome may be constrained by fixation of advantageous mutations associated with hitchhiking effect. This study examined restriction fragment length polymorphisms of four natural Aedes aegypti mosquito populations from Trinidad and Tobago, at 16 loci. These populations have been subjected to organophosphate (OP) insecticide treatments for more than two decades, while dichlor-diphenyltrichlor (DDT) was the insecticide of choice prior to this period. We predicted that genes closely linked to the OP target loci would exhibit reduced genetic variation as a result of the hitchhiking effect associated with intensive OP insecticide selection. We also predicted that genetic variability of the genes conferring resistance to DDT and loci near the target site would be similar to other unlinked loci. As predicted, reduced genetic variation was found for loci in the general chromosomal region of a putative OP target site, and these loci generally exhibited larger [F.sub.ST] values than other random loci. In contrast, the gene conferring resistance to DDT and its linked loci show polymorphisms and genetic differentiation similar to other random loci. The reduced genetic variability and apparent gene deletion in some regions of chromosome 1 likely reflect the hitchhiking effect associated with OP insecticide selection.

Published
1998

49. Mapping a quantitative trait locus involved in melanotic encapsulation of foreign bodies in the malaria vector, Anopheles gambiae

Author

Gorman, Maureen J., Severson, David W., Cornel, Anton J., Collins, Frank H., and Paskewitz, Susan M.

Subjects
Anopheles -- Genetic aspects, Plasmodium -- Genetic aspects, Biological sciences
Abstract

A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. We report the results of broad-scale quantitative trait locus (QTL) mapping of the encapsulation trait using the bead model system. Interval mapping using the method of maximum likelihood identified one major QTL, Pen1. The 13.7-cM interval containing Pen1 was defined by marker AGH157 at 8E and AGH46 at 7A on 2R. Pen1 was associated with a maximum LOD score of 9.0 and accounted for 44% of the phenotypic variance in the distribution of phenotypes in the backcross. To test if this QTL is important for encapsulation of Plasmodium berghei, [F.sub.2] progeny were infected with P. berghei and evaluated for degree of parasite encapsulation. For each of the two markers that define the interval containing Pen1, a significant difference of encapsulation was seen in progeny with at least one refractory allele in contrast with homozygous susceptible progeny. These results suggest that Pen1 is important for melanotic encapsulation of Plasmodium as well as beads.

Published
1997

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