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343 results on '"Severs, Nicholas J."'

2. The ninth victory of German ace Hans-Joachim Buddecke

Author

Severs, Nicholas J.

Subjects
ACES, WORLD WAR I - Aerial Operations, German, WORLD WAR I - Aerial Operations, British, AIRPLANES, FAMOUS AND HISTORIC, PILOTS
Abstract

tab bibliog por map illus

Published
2006

3. Cardiac physiology

Author

Evans, Rhys D., additional, MacLeod, Kenneth T., additional, Marston, Steven B., additional, Severs, Nicholas J., additional, and Sugden, Peter H., additional

Published
2020
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5. List of Contributors

Author

Bache, Robert J., primary, Baldwin, Kenneth M., additional, Barclay, Chris J., additional, Benson, Alan P., additional, Bowen, T. Scott, additional, Burnley, Mark, additional, Celichowski, Jan, additional, Chabowski, Adrian, additional, Chapman, Brian, additional, Craig, Jesse C., additional, Davis, Jonathan P., additional, Davison, Glen, additional, Degens, Hans, additional, di Prampero, Pietro E., additional, Duchateau, Jacques, additional, Duda, Krzysztof, additional, Duncker, Dirk J., additional, Enoka, Roger M., additional, Fell, Marc J., additional, Fisher, James P., additional, Gao, Lie, additional, Górski, Jan, additional, Grassi, Bruno, additional, Haddad, Fadia, additional, Hammond, Kelly M., additional, Han, June-Chiew, additional, Hearris, Mark A., additional, Heymsfield, Steven B., additional, Janssen, Paul M.L., additional, Jones, Andrew M., additional, Jones, Arwel Wyn, additional, Kemmler, Wolfgang, additional, Kemp, Graham J., additional, Kilarski, Wincenty, additional, Koltai, Erika, additional, Krutki, Piotr, additional, Laughlin, M. Harold, additional, Legård, Grit E., additional, Loiselle, Denis S., additional, Majerczak, Joanna, additional, Merkus, Daphne, additional, Morton, James P., additional, Nieckarz, Zenon, additional, Osgnach, Cristian, additional, Pedersen, Bente K., additional, Poole, David C., additional, Radak, Zsolt, additional, Roseguini, Bruno Tesini, additional, Rossiter, Harry B., additional, Secher, Niels H., additional, Severs, Nicholas J., additional, Szkutnik, Zbigniew, additional, Taberner, Andrew J., additional, Tikunova, Svetlana B., additional, Tran, Kenneth, additional, Vanhatalo, Anni, additional, von Stengel, Simon, additional, Wang, Hanjun, additional, Zoladz, Jerzy A., additional, and Zucker, Irving H., additional

Published
2019
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20. Cardiac physiology

Author

Evans, Rhys, primary, MacLeod, Kenneth T., additional, Marston, Steven B., additional, Severs, Nicholas J., additional, and Sugden, Peter H., additional

Published
2010
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25. The cardiac muscle cell

Author

Severs, Nicholas J.

Subjects
Muscle cells -- Research, Heart muscle -- Research, Biological sciences
Published
2000

46. Species-specific difference in distribution of voltage-gated L-type [Ca.sup.2+] channels of cardiac myocytes

Author

TAKAGISHI, YOSHIKO, YASUI, KENJI, SEVERS, NICHOLAS J., and MURATA, YOSHIHARU

Subjects
Rabbits -- Physiological aspects, Rats -- Physiological aspects, Excitation (Physiology) -- Research, Biological sciences
Abstract

Takagishi, Yoshiko, Kenji Yasui, Nicholas J. Severs, and Yoshiharu Murata. Species-specific difference in distribution of voltage-gated L-type [Ca.sup.2+] channels of cardiac myocytes. Am J Physiol Cell Physiol 279: C1963-C1969, 2000.--[Ca.sup.2+] influx via sarcolemmal voltage-dependent [Ca.sup.2+] channels (L-type [Ca.sup.2+] channels) is the fundamental step in excitation-contraction (E-C) coupling in cardiac myocytes. Physiological and pharmacological studies reveal species-specific differences in E-C coupling resulting from a difference in the contribution of [Ca.sup.2+] influx and intracellular [Ca.sup.2+] release to activation of contraction. We investigated the distribution of L-type [Ca.sup.2+] channels in isolated cardiac myocytes from rabbit and rat ventricle by correlative immuno-confocal and immunogold electron microscopy. Immunofluorescence labeling revealed discrete spots in the surface plasma membrane and transverse (T) tubules in rabbit myocytes. In rat myocytes, labeling appeared more intense in T tubules than in the surface sarcolemma. Immunogold electron microscopy extended these findings, showing that the number of gold particles in the surface plasma membrane was significantly higher in rabbit than rat myocytes. In rabbit myocyte plasma membrane, the gold particles were distributed as clusters in both regions that were associated with junctional sarcoplasmic reticulum and those that were not. The findings are consistent with the idea that influx of [Ca.sup.2+] via surface sarcolemmal [Ca.sup.2+] channels contributes to intracellular [Ca.sup.2+] to a greater degree in rabbit than in rat myocytes. rabbit and rat ventricular myocytes; immunoconfocal microscopy; immunoelectron microscopy; excitation-contraction coupling

Published
2000

47. Lipid droplet associated proteins:an emerging role in atherogenesis

Author

Buers, Insa, Hofnagel, Oliver, Ruebel, Anneke, Severs, Nicholas J., and Robenek, Horst

Subjects
PAT proteins, lipids (amino acids, peptides, and proteins), Atherosclerosis, Lipid droplets, 61 - Medicina
Abstract

Coronary heart disease and stroke, caused by rupture of atherosclerotic plaques in the arterial wall, are the major causes of death in industrialized countries. A key event in the pathogenesis of atherosclerosis is the transformation of smooth muscle cells and in particular of macrophages into foam cells, a result of massive accumulation of lipid droplets. It is well known that the formation of these lipid droplets is a result of the uninhibited uptake of modified lipoproteins by scavenger receptors. However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets. Here we review recent findings and assess the current state of knowledge on lipid droplets and their PAT proteins in atherogenesis.

Published
2011

48. Topography of Lipid Droplet-Associated Proteins: Insights from Freeze-Fracture Replica Immunogold Labeling

Author

Robenek, Horst, Buers, Insa, Robenek, Mirko J., Hofnagel, Oliver, Ruebel, Anneke, Troyer, David, and Severs, Nicholas J.

Subjects
Article Subject
Abstract

Lipid droplets are not merely storage depots for superfluous intracellular lipids in times of hyperlipidemic stress, but metabolically active organelles involved in cellular homeostasis. Our concepts on the metabolic functions of lipid droplets have come from studies on lipid droplet-associated proteins. This realization has made the study of proteins, such as PAT family proteins, caveolins, and several others that are targeted to lipid droplets, an intriguing and rapidly developing area of intensive inquiry. Our existing understanding of the structure, protein organization, and biogenesis of the lipid droplet has relied heavily on microscopical techniques that lack resolution and the ability to preserve native cellular and protein composition. Freeze-fracture replica immunogold labeling overcomes these disadvantages and can be used to define at high resolution the precise location of lipid droplet-associated proteins. In this paper illustrative examples of how freeze-fracture immunocytochemistry has contributed to our understanding of the spatial organization in the membrane plane and function of PAT family proteins and caveolin-1 are presented. By revisiting the lipid droplet with freeze-fracture immunocytochemistry, new perspectives have emerged which challenge prevailing concepts of lipid droplet biology and may hopefully provide a timely impulse for many ongoing studies.

Published
2011
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50. Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line

Author

Dias, Priyanthi, primary, Desplantez, Thomas, additional, El-Harasis, Majd A., additional, Chowdhury, Rasheda A., additional, Ullrich, Nina D., additional, Cabestrero de Diego, Alberto, additional, Peters, Nicholas S., additional, Severs, Nicholas J., additional, MacLeod, Kenneth T., additional, and Dupont, Emmanuel, additional

Published
2014
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