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1. Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.

Author

Blum, David, Cailliau, Emeline, Béhal, Hélène, Vidal, Jean‐Sébastien, Delaby, Constance, Buée, Luc, Allinquant, Bernadette, Gabelle, Audrey, Bombois, Stéphanie, Lehmann, Sylvain, Schraen‐Maschke, Susanna, Hanon, Olivier, Blanc, Frédéric, Boudali, Yasmina, Touchon, Jacques, Seux, Marie‐Laure, Lenoir, Hermine, Bayle, Catherine, Delmaire, Christine, and Delbeuck, Xavier

Abstract

INTRODUCTION: We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. METHODS: MCI (N = 147) and AD (N = 116) patients of the Biomarker of AmyLoid pepTide and AlZheimer's diseAse Risk (BALTAZAR) cohort reported their caffeine intake at inclusion using a dedicated survey. Associations of caffeine consumption with memory impairments and CSF biomarkers (tau, p‐tau181, amyloid beta 1‐42 [Aβ1‐42], Aβ1‐40) were analyzed using logistic and analysis of covariance models. RESULTS: Adjusted on Apolipoprotein E (APOE ε4), age, sex, education level, and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95% CI: 1.13 to 5.46]; p = 0.023) and lower CSF Aβ1‐42 (p = 0.047), Aβ1‐42/Aβ1‐40 (p = 0.040), and Aβ1‐42/p‐tau181 (p = 0.020) in the whole cohort. DISCUSSION: Data support the beneficial effect of caffeine consumption to memory impairments and CSF amyloid markers in MCI and AD patients. Highlights: We studied the impact of caffeine consumption in the BALTAZAR cohort.Low caffeine intake is associated with higher risk of being amnestic in MCI/AD patients.Caffeine intake is associated with CSF biomarkers in AD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

Author

Hanon, Olivier, Blanc, Frédéric, Boudali, Yasmina, Gabelle, Audrey, Seux, Marie–Laure, Lenoir, Hermine, Bayle, Catherine, Bombois, Stéphanie, Delbeuck, Xavier, Moulin, Florence, Duron, Emmanuelle, Latour, Florence, Plichart, Matthieu, Pichierri, Sophie, Orvoën, Galdric, Galbrun, Evelyne, Castelnovo, Giovanni, Volpe–Gillot, Lisette, Labourée, Florien, Cassagnaud, Pascaline, Paquet, Claire, Lala, Françoise, Dumurgier, Julien, Rigaud, Anne–Sophie, Perret–Guillaume, Christine, Alonso, Eliana, du Boisgueheneuc, Foucaud, Hugonot–Diener, Laurence, Rollin–Sillaire, Adeline, Martinaud, Olivier, Boully, Clémence, Spivac, Yann, Devendeville, Agnès, Belmin, Joël, Robert, Philippe–Henri, Dantoine, Thierry, Caillard, Laure, Wallon, David, Hannequin, Didier, Sastre, Nathalie, Haffen, Sophie, Kearney–Schwartz, Anna, Novella, Jean–Luc, Deramecourt, Vincent, Chauvire, Valérie, Abitbol, Gabiel, Schwald, Nathalie, Hommet, Caroline, Sellal, François, Cariot, Marie–Ange, Abdellaoui, Mohamed, Benisty, Sarah, Gherabli, Salim, Anthony, Pierre, Bloch, Frédéric, Charasz, Nathalie, Chauvelier, Sophie, Gaubert, Jean–Yves, Sacco, Guillaume, Guerin, Olivier, Boddaert, Jacques, Paccalin, Marc, Mackowiak, Marie–Anne, Rabus, Marie–Thérèse, Gissot, Valérie, Benetos, Athanase, Picard, Candice, Guillemaud, Céline, Gervais, Claire, Hugon, Jaques, Michel, Jean–Marc, David, Jean–Philippe, Paulin, Marion, Ousset, Pierre–Jean, Vandel, Pierre, Pariel, Sylvie, Camus, Vincent, Chawakilian, Anne, Joffredo, Léna, Troussiere, Anne–Cécile, Adam, Cécile, Dupuy, Diane, Paillaud, Elèna, Briault, Hélène, Saulnier, Isabelle, Mondon, Karl, Picat, Marie–Agnès, Laurent, Marie, Godefroy, Olivier, Daheb, Rezki, Libercier, Stéphanie, Krabchi, Djamila, Chupin, Marie, Vidal, Jean–Sébastien, Chaussade, Edouard, Lehmann, Sylvain, Schraen-Maschke, Suzanna, Vidal, Jean-Sébastien, Allinquant, Bernadette, Tréluyer, Jean-Marc, Gelé, Patrick, Delmaire, Christine, Blanc, Fredéric, Mangin, Jean-François, Buée, Luc, Touchon, Jacques, Hugon, Jacques, Vellas, Bruno, Berrut, Gilles, Volpe-Gillot, Lisette, Robert, Philippe-Henri, Novella, Jean-Luc, and Rigaud, Anne-Sophie

Published
2018
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16. Diabetes Mellitus and Cognition

Author

Frison, Eric, Proust-Lima, Cecile, Mangin, Jean-Francois, Habert, Marie-Odile, Bombois, Stephanie, Ousset, Pierre-Jean, Pasquier, Florence, Hanon, Olivier, Paquet, Claire, Gabelle, Audrey, Ceccaldi, Mathieu, Annweiler, Cédric, Krolak-Salmon, Pierre, Béjot, Yannick, Belin, Catherine, Wallon, David, Sauvee, Mathilde, Beaufils, Emilie, Bourdel-Marchasson, Isabelle, Jalenques, Isabelle, Chupin, Marie, Chêne, Geneviève, Dufouil, Carole, Allard, Michèle, Andrieu, Sandrine, Anthony, Pierre, Astier, Christine, Augier, Alexandre, Auguste, Nicolas, Auriacombe, Sophie, Avet, John, Bailon, Olivier, Barral, Fabrice-Guy, Barré, Jean, Barthelaix, Annick, Bayle, Catherine, Beauchet, Olivier, Belkacem, Samia, Ben Salem, Douraied, Bennys, Karim, Bera, Géraldine, Berger, Eric, Berger, Marc G, Bergouin, Emilie, Bertin-Hugault, François, Bertrand, Guillaume, Bertrand, François-Xavier, Beze, Catherine, Boilet, Valérie, Bonafé, Alain, Boudali, Yasmina, Bouhladour, Hatem, Boully, Clémence, Bouteloup, Vincent, Boutet, Claire, Bracard, Serge, Brangier, Antoine, Brillet, Pierre-Yves, Caillard, Laure, Calvas, Fabienne, Camus, Agnès, Camus, Vincent, Canaple, Sandrine, Carpentier, Antoine, Cassagnaud, Pascaline, Cattin, Françoise, Chamard, Ludivine, Chanalet, Stéphane, Chastan, Mathieu, Chauvelier, Sophie, Chauvire, Valérie, Cheriet, Samia, Clotagatide, Anthony, Cognat, Emmanuel, Cohen, Lora, Constans, Jean-Marc, Coste, Marie-Hélène, Cottier, Jean-Philippe, Cotton, François, Couret, Isabelle, Couturier, Olivier-François, Cowppli-Bony, Pascale, Cressot, Véronique, Crétin, Benjamin, Danaila, Keren, Darcourt, Jacques, Dartigues, Jean-François, Dascalita, Ana-Maria, David, Renaud, De Petigny, Xavier, De Verbizier-Lonjon, Delphine, Decousus, Marielle, Defouilloy, Isabelle, Delmaire, Christine, Delrieu, Julien, Demuyinck, Catherine, Deramecourt, Vincent, Deramond, Hervé, Desmidt, Thomas, Desruet, Marie-Dominique, Detour, Julien, Devendeville, Agnès, Didic, Mira, Doireau, Maritchu, Santos, Antonio Dos, Douillet, Patrice, Du Boisgueheneuc, Foucaud, Dubail, Delphine, Ducroq-Ducastaing, Laure, Dumurgier, Julien, Dupuy, Diane, Duron, Emmanuelle, Dygai-Cochet, Inna, Eder, Véronique, Epelbaum, Stéphane, Etcharry-Bouyx, Frédérique, Fagret, Daniel, Faisant, Catherine, Farid, Karim, Fédérico, Denis, Felician, Olivier, Fernandez, Philippe, Fosse, Pacôme, Foubert-Samier, Alexandra, Franck, Isabelle, Galitzky, Monique, Gallazzini-Crepin, Céline, Gantchev, Radka, Garbarg-Chenon, Laurence, Gautier, Guillaume, Gerardin, Emmanuel, Gervais, Claire, Getenet, Jean-Claude, Girard, Nadine, Giraud, Fabienne, Girtanner, Chantal, Gissot, Valérie, Grangeon, Caroline, Grucker, Daniel, Guedj, Eric, Gueriot, Claude, Guilhermet, Yves, Guillevin, Rémy, Haffen, Sophie, Hannequin, Didier, Harston, Sandrine, Hitzel, Anne, Hommet, Caroline, Hossein-Foucher, Claude, Hubele, Fabrice, Jacquin-Piques, Agnès, Jean, Betty, Jenn, Joanne, Joly, Laure, Jonveaux, Thérèse, Julian, Adrien, Kas, Aurélie, Kearney-Schwartz, Anna, Keles, Alice, Kelly, Antony, Keromnes, Nathalie, Koric, Lejla, Krainik, Alexandre, Kremer, Stéphane, Labourée, Florian, Lacoeuille, Franck, Lala, Francoise, Lamy, Chantal, Laplanche, Jean-Louis, Launay, Cyrille, Lehericy, Stéphane, Lehmann, Sylvain, Lenoir, Hermine, Levy, Marcel, Libercier, Stéphanie, Mackowiak-Cordoliani, Marie-Anne, Magnin, Eloi, Makaroff, Zaza, Marantidou, Athina, Marcet, Isabelle, Marelli, Cécilia, Marilier, Sophie, Martin, Idalie, Martinaud, Olivier, Martin-Hunyadi, Catherine, Medjoul, Aïcha, Merlet, Isabelle, Mestas, Danielle, Meyer, Marc-Etienne, Michel, Jean-Marc, Michon, Agnès, Migeon-Duballet, Isabelle, Mondon, Karl, Morgat, Clément, Moullart, Véronique, Moussard, Christian, Mouton, Aurélie, Namer, Izzie Jacques, Niewiadomski, Georges, Nivaggioni, Guillaume, Noblet, Marie, Nonent, Michel, Nourhashemi, Fati, Oesterle, Hélène, Orvoen, Galdric, Pallardy, Amandine, Pare, Pierre-Yves, Pasco, Anne, Payoux, Pierre, Pays, Cécile, Pellegrin, Isabelle, Perdrisot, Rémy, Perin, Bertille, Perret-Guillaume, Christine, Petyt, Grégory, Philippi, Nathalie, Pinganaud, Geneviève, Plichart, Matthieu, Pop, Gabriel, Puel, Michèle, Queneau, Mathieu, Querellou, Solène, Quillard-Muraine, Muriel, Quipourt, Valérie, Rachez, Chloé, Razzouk-Cadet, Micheline, Rigaud, Anne-Sophie, Robin-Ismer, Hélène, Rodallec, Mathieu, Rolland, Yves, Rollin-Sillaire, Adeline, Rouaud, Olivier, Roubaud, Caroline, Rouch, Isabelle, Roux, Julie, Sacco, Guillaume, Salaun, Pierre-Yves, Salmon, François, Sanchez, Alicia, Santiago-Ribeiro, Maria-Joao, Sarciron, Alain, Sastre-Hengan, Nathalie, Scheiber, Christian, Schneider, Anne-Marie, Semah, Franck, Serra, Amélie, Seux, Marie-Laure, Sordet-Guépet, Hélène, Soto, Maria Eugenia, Tafani, Mathieu, Tanguy, Jean-Yves, Taroux, Michael, Teichmann, Marc, Terrat, Catherine, Thabet, Jamila, Thalamas, Claire, Thomas-Anterion, Catherine, Troussière, Anne-Cécile, Ursu, Renata, Vera, Pierre, Vercelletto, Martine, Vercruysse, Olivier, Verger, Antoine, Viau, Philippe, Videau, Marie-Neige, Voisin, Thierry, Wagemann, Nathalie, Waissi-Sediq, Aziza, Xie, Jing, Yeni, Nathanaëlle, Zanca, Michel, and Zinszner, Jean

Published
2021
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17. Pulse Wave Velocity Is Associated With Greater Risk of Dementia in Mild Cognitive Impairment Patients

Author

Rouch, Laure, primary, Cestac, Philippe, additional, Sallerin, Brigitte, additional, Andrieu, Sandrine, additional, Bailly, Henri, additional, Beunardeau, Maëlle, additional, Cohen, Adrien, additional, Dubail, Delphine, additional, Hernandorena, Intza, additional, Seux, Marie-Laure, additional, Vidal, Jean-Sébastien, additional, and Hanon, Olivier, additional

Published
2018
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18. A17091 Pulse wave velocity is associated with greater risk of dementia in mild cognitive impairment patients

Author

Rouch, Laure, primary, Cestac, Philippe, additional, Sallerin, Brigitte, additional, Andrieu, Sandrine, additional, Bailly, Henri, additional, Beunardeau, Maëlle, additional, Cohen, Adrien, additional, Dubail, Delphine, additional, Hernandorena, Intza, additional, Seux, Marie Laure, additional, Vidal, Jean Sébastien, additional, Hanon, Olivier, additional, and Rouch, Laure, additional

Published
2018
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20. Author’s reply

Author

Staessen, Jan A, Forette, Françoise, Thijs, Lutgarde, Gasowski, Jerzy, and Seux, Marie-Laure

Published
1999
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21. Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis

Author

Duron, Emmanuelle, Vidal, Jean-Sébastien, Funalot, Benoît, Viollet, Cécile, Seux, Marie-Laure, Treluyer, Jean-Marc, Epelbaum, Jacques, Bouc, Yves Le, Hanon, Olivier, Camelo, Serge, Lajavardi, Laure, Bochot, Amélie, Goldenberg, Brigitte, Naud, Marie-Christine, Brunel, Nadège, Lescure, Bernadette, Klein, Christophe, Fattal, Elias, Behar-Cohen, Francine, De Kozak, Yvonne, Centre de Mémoire de Ressources et de Recherche [Paris Broca], AP-HP - Hôpital Broca [Paris], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Génétique Médicale [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-0901, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Neurobiologie de la Croissance et de la Senescence, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dpt Gériatrie [CHU Broca], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Maladies Oculaires : Innovations Therapeutiques, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR58-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer, Inflammation, Hormones, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de neurologie [Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physico-chimie, pharmacotechnie, biopharmacie (PCPB), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and École pratique des hautes études (EPHE)

Subjects
MESH: Cytokines, MESH: Rats, Elderly participants, [SDV]Life Sciences [q-bio], MESH: Vasoactive Intestinal Peptide, MESH: Vitreous Body, MESH: Macrophages, MESH: Lymph Nodes, MESH: Rhodamines, Atrial fibrillation, MESH: Male, Insulin-like growth factor binding protein-3, MESH: T-Lymphocytes, MESH: Arrestin, MESH: Autoimmune Diseases, MESH: Cell Proliferation, MESH: Uveitis, MESH: Retinitis, MESH: Injections, MESH: Liposomes, MESH: Animals, MESH: Rats, Inbred Lew, Insulin-like growth factor-I, MESH: Disease Models, Animal
Abstract

International audience; Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.

Published
2014
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23. Analyse de la réponse des aidants informels des patients atteints de troubles cognitifs majeurs à une proposition d’une évaluation médico-psycho-sociale.

Author

Krabchi, Djamila, Vidal, Jean-Sébastien, Chauvelier, Sophie, Seux, Marie-Laure, Cantegreil-Kallen, Ignatia, Jailany, Hariniaina, Hanon, Olivier, Rigaud, Anne-Sophie, and Duron, Emmanuelle

Abstract

Copyright of Gériatrie et Psychologie Neuropsychiatrie du Vieillissement is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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25. Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment

Author

Duron, Emmanuelle, primary, Vidal, Jean-Sébastien, additional, Bounatiro, Samira, additional, Ben Ahmed, Sana, additional, Seux, Marie-Laure, additional, Rigaud, Anne-Sophie, additional, Hanon, Olivier, additional, Viollet, Cécile, additional, Epelbaum, Jacques, additional, and Martel, Guillaume, additional

Published
2014
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28. Support for patients with Alzheimer's disease and their caregivers by gerontechnology

Author

RIGAUD, ANNE-SOPHIE, additional, PINO, MARIBEL, additional, WU, YA-HUEI, additional, DE ROTROU, JOCELYNE, additional, BOULAY, MELODIE, additional, SEUX, MARIE-LAURE, additional, HUGONOT-DIENER, LAURENCE, additional, DE SANT’ANNA, MARTHA, additional, MOULIN, FLORENCE, additional, LE GOUVERNEUR, GREGORY, additional, CRISTANCHO-LACROIX, VICTORIA, additional, and LENOIR, HERMINE, additional

Published
2011
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33. Initiation of warfarin therapy in elderly medical inpatients: A safe and accurate regimen

Author

Siguret, Virginie, primary, Gouin, Isabelle, additional, Debray, Matthieu, additional, Perret-Guillaume, Christine, additional, Boddaert, Jacques, additional, Mahé, Isabelle, additional, Donval, Valérie, additional, Seux, Marie-Laure, additional, Romain-Pilotaz, Marjolaine, additional, Gisselbrecht, Mathilde, additional, Verny, Marc, additional, and Pautas, Eric, additional

Published
2005
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34. Calcium Channel Blockade and Cardiovascular Prognosis in the European Trial on Isolated Systolic Hypertension

Author

Staessen, Jan A., primary, Thijs, Lutgarde, additional, Fagard, Robert H., additional, Birkenhäger, Willem H., additional, Arabidze, Guramy, additional, Babeanu, Speranta, additional, Gil-Extremera, Blas, additional, Bulpitt, Christopher J., additional, Davidson, Christopher, additional, de Leeuw, Peter W., additional, Efstratopoulos, Aris D., additional, Fletcher, Astrid E., additional, Fogari, Roberto, additional, Jääskivi, Matti, additional, Kawecka-Jaszcz, Kalina, additional, Nachev, Choudomir, additional, Petrie, James C., additional, Seux, Marie-Laure, additional, Tuomilehto, Jaakko, additional, Webster, John, additional, and Yodfat, Yair, additional

Published
1998
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35. Correlates of cognitive status of old patients with isolated systolic hypertension

Author

Seux, Marie-Laure, primary, Thijs, Lut, additional, Forette, Françoise, additional, Staessen, Jan A., additional, Birkenhäger, Willem H., additional, Bulpitt, Christopher J., additional, Girerd, Xavier, additional, Jääskivi, Matti, additional, Vanhanen, Hannu, additional, Kivinen, Paula, additional, Yodfat, Yair, additional, Vänskä, Olavi, additional, Antikainen, Riitta, additional, Laks, Tovio, additional, Webster, John R., additional, Hakamäki, Tapio, additional, Lehtomäki, Erkki, additional, Lilov, Emil, additional, Grigorov, Mladen, additional, Janculova, Krassimira, additional, Halonen, Kari, additional, Kohonen-Jalonen, Paula, additional, Kermowa, Rumiana, additional, Nachev, Chodoumir, additional, and Tuomilehto, Jaakko, additional

Published
1998
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37. Effects of Antihypertensive Therapy on Cognitive Decline in Alzheimer's Disease.

Author

Duron, Emmanuelle, Rigaud, Anne-Sophie, Dubail, Delphine, Mehrabian, Shima, Latour, Florence, Seux, Marie-Laure, and Hanon, Olivier

Subjects
ANTIHYPERTENSIVE agents, CARDIOVASCULAR agents, ALZHEIMER'S disease, PRESENILE dementia, COGNITIVE ability, BLOOD pressure
Abstract

BackgroundTherapeutic trials concerning the effect of antihypertensive therapy on cognition have produced controversial findings. Our objective was to evaluate the impact of antihypertensive therapy on the cognitive function in subjects already diagnosed with Alzheimer's disease (AD).MethodsWe conducted an observational study in a memory clinic assessing outpatients suffering from AD. A total of 321 patients were included. Cognitive function was assessed yearly by the Mini-Mental State Examination (MMSE; score/30).ResultsThe mean age of patients was 78.1 ± 6 years, 54% of them received antihypertensive therapy and the mean MMSE scores were similar in both groups (patients taking antihypertensive therapy and patient without antihypertensive therapy). The mean follow-up was 34.1 ± 6 months. MMSE means were significantly higher among patients using antihypertensive therapy compared to those without antihypertensive therapy (MMSE scores = 21.9 ± 4.9 vs. 21.2 ± 5.1 at 1 year (P = 0.001); 20.8 ± 5.5 vs. 19.4 ± 5.7 at 2 years (P < 0.001); 19.0 ± 6.7 vs. 17.5 ± 6.4 at 3 years (P < 0.001)), after adjustment for age, gender, education level, systolic blood pressure (SBP), and diastolic blood pressure (DBP) at baseline, MMSE at baseline, coronary heart disease, statins, and antiplatelet agents' consumption. Furthermore, the use of antihypertensive therapy was associated with a lower estimated risk of cognitive decline (as defined by a decrease of at least one point in MMSE score over time) (hazard ratio = 0.61; 95% confidence interval = 0.45–0.81) after adjustment for the same factors.ConclusionsThese results suggest an association between antihypertensive therapy, a lower decrease in mean MMSE and a lower cognitive decline over time in AD.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.119American Journal of Hypertension 2009; 22, 9, 1020–1024. doi:10.1038/ajh.2009.119 [ABSTRACT FROM AUTHOR]

Published
2009
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38. Blood Pressure, Cognitive Functions, and Prevention of Dementias in Older Patients with...

Author

Burkenhager, Willem H., Forette, Francoise, Seux, Marie-Laure, Wang, Ji-Guang, and Staessen, Jan A.

Subjects
PATIENTS, HYPERTENSION, BLOOD pressure, DEMENTIA prevention
Abstract

Focuses on blood pressure, cognitive functions and prevention of dementias in older patients with hypertension. Incidence of degenerative and vascular dementias; Cognitive performance and dementia in relation to blood pressure; Effects of antihypertensive treatment.

Published
2001

40. L'accompagnement du patient

Author

Seux, Marie-Laure, De Rotrou, Jocelyne, Seux, Marie-Laure, and De Rotrou, Jocelyne

Abstract

Soigner dans toutes les dimensions de la santé, respecter, protéger, informer, soulager, chacun de ses rôles essentiels pour le médecin impliqué dans l’accompagnement des patients affectés par la maladie d’Alzheimer est souligné dans le serment d’Hippocrate. Prendre en charge un patient c’est avant tout instaurer une relation avec lui mais également souvent avec son entourage. C’est soigner les symptômes liés à la maladie d’Alzheimer par des traitements médicamenteux ou non. C’est aussi soigner les autres problèmes de santé tout en tenant compte de la maladie d’Alzheimer. C’est proposer au patient l’apport de compétences multi-disciplinaires. C’est accompagner dans la durée en s’adaptant à l’évolution de l’état du patient et des éventuelles modifications de l’entourage. C’est être disponible., SURROUNDING PATIENTS All the dimensions of health care are stipulated in the Hippocratic Oath. Respect, protection, information, relief are essential in the role played by doctors when caring for patients suffering from Alzheimer’s Disease. To take charge of patients is, above all, to build a relationship with them but very often with their entourage also. It is to treat the disease’s symptoms through medication or not. It is also to treat their other health problems whilst bearing in mind their Alzheimer’s condition. It is to offer the patient multi-disciplinary skills. It is to offer long-term accompaniment whilst adapting to patients’ evolving state and to possible changes in their entourage. It is to be available.

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