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Abstract We study infinite-distance limits in the complex structure moduli space of elliptic Calabi-Yau threefolds. In F-theory compactifications to six dimensions, such limits include infinite-distance trajectories in the non-perturbative open string moduli space. The limits are described as degenerations of elliptic threefolds whose central elements exhibit non-minimal elliptic fibers, in the Kodaira sense, over curves on the base. We show how these non-crepant singularities can be removed by a systematic sequence of blow-ups of the base, leading to a union of log Calabi-Yau spaces glued together along their boundaries. We identify criteria for the blow-ups to give rise to open chains or more complicated trees of components and analyse the blow-up geometry. While our results are general and applicable to all non-minimal degenerations of Calabi-Yau threefolds in codimension one, we exemplify them in particular for elliptic threefolds over Hirzebruch surface base spaces. We also explain how to extract the gauge algebra for F-theory probing such reducible asymptotic geometries. This analysis is the basis for a detailed F-theory interpretation of the associated infinite-distance limits that will be provided in a companion paper [1].

Background: We compared the prognostic value of the C-reactive protein (CRP)-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and modified Glasgow prognostic score (mGPS) with the Sequential Organ Failure Assessment (SOFA) score in an intensive care unit (ICUs). Methods: This study used the data of 53,877 adult patients admitted to an ICU between June 2013 and May 2022. Using the CAR, NLR, and mGPS values, as well as the SOFA score from the ICU, we conducted multivariable logistic regression analysis and used the receiver operating characteristic (ROC) curve to compare the predictive value for 28-day and 1-year mortality. Results: A total of 2419 patients (4.5%) died within 28 days, and 6209 (11.5%) patients died within 1 year. After an adjustment, all predictors were found to be independent risk factors for 28-day mortality (odds ratio [OR] 1.31, 95% confidence interval [CI] 1.29–1.33, p < 0.001 for the SOFA score; OR 1.05, 95% CI 1.03–1.07, p < 0.001 for CAR; OR 1.01, 95% CI 1.00–1.02, p < 0.001 for the NLR; and OR 1.19, 95% CI 1.08–1.30, p < 0.001 for the mGPS). This trend persisted for the 1-year mortality. In ROC curve analysis, the CAR showed better predictability than the NLR and mGPS. Furthermore, the predictive power of the CAR was significantly higher than that of the SOFA score for 1-year mortality. Conclusions: The CAR, NLR, and mGPS values at ICU admission were independent risk factors of mortality after ICU admission. The predictive value of CAR was higher than that of the SOFA score for 1-year mortality. CAR assessment at ICU admission may be a feasible predictor of long-term mortality.

Abstract Motivated by the Swampland Distance and the Emergent String Conjecture of Quantum Gravity, we analyse the infinite distance degenerations in the complex structure moduli space of elliptic K3 surfaces. All complex degenerations of K3 surfaces are known to be classified according to their associated Kulikov models of Type I (finite distance), Type II or Type III (infinite distance). For elliptic K3 surfaces, we characterise the underlying Weierstrass models in detail. Similarly to the known two classes of Type II Kulikov models for elliptic K3 surfaces we find that the Weierstrass models of the more elusive Type III Kulikov models can be brought into two canonical forms. We furthermore show that all infinite distance limits are related to degenerations of Weierstrass models with non-minimal singularities in codimension one or to models with degenerating generic fibers as in the Sen limit. We explicitly work out the general structure of blowups and base changes required to remove the non-minimal singularities. These results form the basis for a classification of the infinite distance limits of elliptic K3 surfaces as probed by F-theory in the companion paper [1]. The Type III limits, in particular, are (partial) decompactification limits as signalled by an emergent affine enhancement of the symmetry algebra.

Abstract We investigate infinite distance limits in the complex structure moduli space of F-theory compactified on K3 to eight dimensions. While this is among the simplest possible arenas to test ideas about the Swampland Distance Conjecture, it is nevertheless non-trivial enough to improve our understanding of the physics for these limiting geometries, including phenomena of emergence. It also provides a perspective on infinite distance limits from the viewpoint of open strings. The paper has two quite independent themes. In the main part we show that all degenerations of elliptic K3 surfaces at infinite distance as analysed in the companion paper [1] can be interpreted as (partial) decompactification or emergent string limits in F-theory, in agreement with the Emergent String Conjecture. We present a unified geometric picture of the possible towers of states that can become light and illustrate our general claims via the connection between Kulikov models of degenerating K3 surfaces and the dual heterotic string. As an application we classify the possible maximal non-abelian Lie algebras and their Kac-Moody and loop extensions that can arise in the infinite distance limits. In the second part we discuss the infinite distance behaviour of certain exact quartic gauge couplings. We encounter a tension with the hypothesis that effective couplings should be fully generated by integrating out massive states. We show that by appropriately renormalizing the string coupling, at least partial emergence can be achieved.

Abstract We investigate holomorphic anomalies of partition functions underlying string compactifications on Calabi-Yau fourfolds with background fluxes. For elliptic fourfolds the partition functions have an alternative interpretation as elliptic genera of N = 1 supersymmetric string theories in four dimensions, or as generating functions for relative, genus zero Gromov-Witten invariants of fourfolds with fluxes. We derive the holomorphic anomaly equations by starting from the BCOV formalism of topological strings, and translating them into geometrical terms. The result can be recast into modular and elliptic anomaly equations. As a new feature, as compared to threefolds, we find an extra contribution which is given by a gravitational descendant invariant. This leads to linear terms in the anomaly equations, which support an algebra of derivatives mapping between partition functions of the various flux sectors. These geometric features are mirrored by certain properties of quasi-Jacobi forms. We also offer an interpretation of the physics from the viewpoint of the worldsheet theory, and comment on holomorphic anomalies at genus one.

Abstract We systematically analyse weak coupling limits for 2-form tensor fields in the presence of gravity. Such limits are significant for testing various versions of the Weak Gravity and Swampland Distance Conjectures, and more broadly, the phenomenon of emergence. The weak coupling limits for 2-forms correspond to certain infinite-distance limits in the moduli space of string compactifications, where asymptotically tensionless, solitonic strings arise. These strings are identified as weakly coupled fundamental strings in a dual frame, which makes the idea of emergence manifest. Concretely we first consider weakly coupled tensor fields in six-dimensional compactifications of F-theory, where the arising tensionless strings play the role of dual weakly coupled heterotic strings. As the main part of this work, we consider certain infinite distance limits of Type IIB strings on K3 surfaces, for which we show that the asymptotically tensionless strings describe dual fundamental Type IIB strings, again on K3 surfaces. By contrast the analogous weak coupling limits of M-theory compactifications are found to correspond to an F-theory limit where an extra dimension emerges rather than tensionless strings. We comment on extensions of our findings to four-dimensional compactifications.

Abstract As a refinement of the Swampland Distance Conjecture, we propose that a quantum gravitational theory in an infinite distance limit of its moduli space either decompactifies, or reduces to an asymptotically tensionless, weakly coupled string theory. We support our claim by classifying, as special cases, the behaviour of M-Theory and Type IIA string theory compactifications on Calabi-Yau three-folds at infinite distances in Kähler moduli space. The analysis comprises three parts: we first classify the possible infinite distance limits in the classical Kähler moduli space of a Calabi-Yau three-fold. Each such limit at finite volume is characterized by a universal fibration structure, for which the generic fiber shrinking in the limit is either an elliptic curve, a K3 surface, or an Abelian surface. In the second part we focus on M-Theory and investigate the nature of the towers of asymptotically massless states that arise from branes wrapped on the shrinking fibers. Depending on which of the three classes of fibrations are considered, we obtain decompactification to F-Theory, or a theory with a unique asymptotically tensionless, weakly coupled heterotic or Type II string, respectively. The latter probes a dual D-manifold which is in general non-geometric. In addition to the intrinsic string excitations, towers of states from M2-branes along non-contractible curves become light and correspond to further wrapping and winding modes of the tensionless heterotic or Type II string. In the third part of the analysis, we consider Type IIA string theory on Calabi-Yau three-folds and show that quantum effects obstruct taking finite volume infinite distance limits in the Kähler moduli space. The only possible infinite distance limit which is not a decompactification limit involves K3-fibrations with string scale fiber volume and gives rise to an emergent tensionless heterotic string.

Purpose There are many studies on sentinel lymph node (SLN) biopsy in thyroid carcinoma but SLN biopsy (SLNB) in papillary thyroid carcinoma (PTC) remains open to debate. Therefore in this retrospective study, the usefulness of SLNB in thyroid carcinoma patients who had micro-PTC without cervical lymphadenopathy was assessed. Methods SLNB was performed in 114 patients who were diagnosed with micro-PTC in a single lobe without palpable or ultrasound-detected lymph node at the tertiary center between January 2012 and December 2013. After SLNB, all patients underwent total thyroidectomy and central neck dissection or thyroid lobectomy and central neck dissection of the single side. Results SLNs were identified in 112 of 114 patients with 41 positive SLNs and 71 negative SLNs on intraoperative frozen sections. However, eight negative patients were found to be positive in the final pathology. Sentinel node identification rate and false negative value of SLNB were 98.2% and 11.3%, respectively. In the univariate analysis, higher lymph node metastasis was detected in men than in women. Higher detection number of SLN showed higher probability of lymph node metastasis. Conclusion SLNB may be helpful in papillary thyroid cancer, especially in male patients. Also, it is useful for the staging of nodal status and clearance of persistent disease.

Abstract We study quantum corrections in four-dimensional theories with N = 1 supersymmetry in the context of Quantum Gravity Conjectures. According to the Emergent String Conjecture, infinite distance limits in quantum gravity either lead to decompactification of the theory or result in a weakly coupled string theory. We verify this conjecture in the framework of N = 1 supersymmetric F-theory compactifications to four dimensions including perturbative α′ as well as non-perturbative corrections. After proving uniqueness of the emergent critical string at the classical level, we show that quantum corrections obstruct precisely those limits in which the scale of the emergent critical string would lie parametrically below the Kaluza-Klein scale. Limits in which the tension of the asymptotically tensionless string sits at the Kaluza-Klein scale, by contrast, are not obstructed. In the second part of the paper we study the effect of quantum corrections for the Weak Gravity Conjecture away from the strict weak coupling limit. We propose that gauge threshold corrections and mass renormalisation effects modify the super-extremality bound in four dimensions. For the infinite distance limits in F-theory the classical super-extremality bound is generically satisfied by a sublattice of states in the tower of excitations of an emergent heterotic string. By matching the F-theory α′-corrections to gauge threshold corrections of the dual heterotic theory we predict how the masses of this tower must be renormalised in order for the Weak Gravity Conjecture to hold at the quantum level.

Abstract We investigate the interplay between the enumerative geometry of Calabi-Yau fourfolds with fluxes and the modularity of elliptic genera in four-dimensional string theories. We argue that certain contributions to the elliptic genus are given by derivatives of modular or quasi-modular forms, which may encode BPS invariants of Calabi-Yau or non-Calabi-Yau threefolds that are embedded in the given fourfold. As a result, the elliptic genus is only a quasi-Jacobi form, rather than a modular or quasi-modular one in the usual sense. This manifests itself as a holomorphic anomaly of the spectral flow symmetry, and in an elliptic holomorphic anomaly equation that maps between different flux sectors. We support our general considerations by a detailed study of examples, including non-critical strings in four dimensions. For the critical heterotic string, we explain how anomaly cancellation is restored due to the properties of the derivative sector. Essentially, while the modular sector of the elliptic genus takes care of anomaly cancellation involving the universal B-field, the quasi-Jacobi one accounts for additional B-fields that can be present. Thus once again, diverse mathematical ingredients, namely here the algebraic geometry of fourfolds, relative Gromow-Witten theory pertaining to flux backgrounds, and the modular properties of (quasi-)Jacobi forms, conspire in an intriguing manner precisely as required by stringy consistency.

DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond. Here, the authors present the crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase bound to undamaged DNA and to DNA containing an intrahelical oxoG lesion and further analyse these structures with molecular dynamics simulations, which allows them to characterise the base-extrusion pathways.

Cytosine base editors have been reported to induce off-target mutations in DNA and RNA. Here the authors identify next-generation CBEs with reduced guide-independent off-target editing profiles and retain high on-target editing activity.

Objectives:The purpose of this study is to evaluate the effects of heavy metals (Zn2+, Pb2+, Hg2+, Cd2+) toxicity in a real-time biosensor which is based on measuring the attenuation of light intensity emitted by Vibrio fischeri. Methods:The inhibition test included four heavy metals and the spiked effluent wastewater. The toxicity of the test samples was assessed by freeze-dried bacteria (Vibrio fischeri NRRL-B-11177). The pH of the samples was adjusted to 7±0.2 before conducting the toxicity tests in oder to eliminate potential pH effects. The results obtained from the real-time biosensor that can be measuring the toxicity of the samples as a function of the emitted light. within a short period time (2 min). And then EC20 and EC50 values was estimated from inhibition curves. Results and Discussion:In case of the inhibition test for dilluents of heavy metals, EC20 values were estimated as < 0.2 mg/L for Zn(II), 0.45 mg/L for Hg(II), 0.58 mg/L for Cd(II) and 1.95 mg/L for Pb(II) and EC50 values were estimated as 0.25 mg/L for Zn(II), 0.5~1.0 mg/L for Hg(II), 1.38 mg/L for Cd(II) and 3.76 mg/L for Pb(II). The sensitivity ranking of heavy metals was in order as Zn(II) > Hg(II), > Cd(II) > Pb(II). In case of the inhibition test for the spiked effluent wastewater, EC20 values were estimated as 0.38 mg/L for Hg(II), 0.58 mg/L for Zn(II), 1.45 mg/L for Pb(II) and 1.95 mg/L for Cd(II) and EC50 values were estimated as 0.53 mg/L for Hg(II), 1.13 mg/L for Zn(II), 6.44 mg/L for Pb(II) and 7.82 mg/L for Cd(II). The sensitivity ranking of the spiked effluent wastewater was in order as Hg(II) > Zn(II) > Pb(II) > Cd(II). Compared to the Emssion Limit Value (ELV) in Korea, the EC20 value of Zn(II) was found to be lower than ELV so that it was suitable for screening of Zn(II) as to meet the criteria of effluent wastewater. However, the other EC20 value of heavy metals can be used to control the unit processes and avoid accidental discharge. Conclusions:The assessment of the toxicity of four heavy metals and spiked samples with them was performed in this study, by real-time biosensor using bioluminescent bacteria. The EC20 value of the spiked sample with Zn(II) has been found to be 0.58 mg/L lower than its ELV so that it was considered as a suitable screening for determining whether or not to exceed the permissible limit value. The use of real-time biosensor is required in combination with physicochemical analyses for an integrated screening of the industrial effluent properties.

Differentiated thyroid cancer (DTC) originating from thyroid tissue is affected by thyrotropin (TSH). TSH suppression therapy is usually recommended after thyroidectomy in cases of DTC. A 57-year-old woman who harbored a very huge recurred lymph node underwent TSH suppression therapy because of the risk of surgical complications. After TSH suppression, the huge neck lymph node exhibited a response and decreased in size. She had been followed up for 144 months. TSH suppression therapy could be considered as an alternative treatment option in a recurred DTC patient with a high perioperative risk.

Abstract We analyse the Weak Gravity Conjecture for chiral four-dimensional F-theory compactifications with N = 1 supersymmetry. Extending our previous work on nearly tensionless heterotic strings in six dimensions, we show that under certain assumptions a tower of asymptotically massless states arises in the limit of vanishing coupling of a U(1) gauge symmetry coupled to gravity. This tower contains super-extremal states whose charge-to-mass ratios are larger than those of certain extremal dilatonic Reissner-Nordström black holes, precisely as required by the Weak Gravity Conjecture. Unlike in six dimensions, the tower of super-extremal states does not always populate a charge sub-lattice. The main tool for our analysis is the elliptic genus of the emergent heterotic string in the chiral N = 1 supersymmetric effective theories. This also governs situations where the heterotic string is non-perturbative. We show how it can be computed in terms of BPS invariants on elliptic four-folds, by making use of various dualities and mirror symmetry. Compared to six dimensions, the geometry of the relevant elliptically fibered four-folds is substantially richer than that of the three-folds, and we classify the possibilities for obtaining critical, nearly tensionless heterotic strings. We find that the (quasi-)modular properties of the elliptic genus crucially depend on the choice of flux background. Our general results are illustrated in a detailed example.

We prove a version of the Weak Gravity Conjecture for 6d F-theory or heterotic string compactifications with 8 supercharges. This sharpens our previous analysis by including massless scalar fields. The latter are known to modify the Weak Gravity Conjecture bound in two a priori independent ways: First, the extremality condition of a charged black hole is modified, and second, the test particles required to satisfy the Weak Gravity Conjecture are subject to additional Yukawa type interactions. We argue on general grounds that at weak coupling, the two types of effects are equivalent for a tower of asymptotically massless charged test particles predicted by the Swampland Distance Conjecture.We then specialize to F-theory compactified on elliptic Calabi–Yau three-folds and prove that the precise numerical bound on the charge-to-mass ratio is satisfied at weak coupling. This amounts to an intriguing coincidence of two a priori different notions of extremality, namely one based on the balance of gauge, gravitational and scalar forces for extremal (non-BPS) black holes, and the other encoded in the modular properties of certain Jacobi forms. In the presence of multiple abelian gauge group factors, the elliptic genus counting these states is a lattice quasi-Jacobi form of higher rank, and we exemplify this in a model with two abelian gauge group factors.

The volatile compounds and sensory profiles of 18 different types of distilled soju, chosen with regard to various raw materials and distillation methods (atmospheric vs. vacuum), were explored using headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) and descriptive analysis. General chemical properties such as pH, total acidity (TA), total soluble solids (°Brix), and lactic acid concentration were also determined. A total of 56 volatile compounds, comprising 31 esters, 11 alcohols, 1 acid, 4 aldehydes, 3 ketones, and 6 miscellaneous compounds, were identified. From the principal component analysis (PCA) of the volatile data, samples made using atmospheric distillation such as MSO and PJU showed a clear difference from decompressed distillation samples. Based on the PCA of the sensory data, there was also a clear distinction between samples by their distillation method. To explore relationships among chemical, volatile, and sensory data sets, multiple factor analysis (MFA) was applied. Yeasty and earthy flavors showed a close relationship with 1-nonanol, octatonic acid, and longer-chain esters such as ethyl phenylacetate and ethyl tetradecanoate, and with chemical parameters such as TA, °Brix, and lactic acid.

Ammonium toxicity is a significant source of pollution from industrial civilization that is disrupting the balance of natural systems, adversely affecting soil and water quality, and causing several environmental problems that affect aquatic and human life, including the strong promotion of eutrophication and increased dissolved oxygen consumption. Thus, a cheap catalyst is required for power generation and detoxification. Herein, compost soil is employed as a novel electrocatalyst for ammonium degradation and high-power generation. Moreover, its effect on catalytic activity and material performances is systematically optimized and compared by treating it with various reducing agents, including potassium ferricyanide, ferrocyanide, and manganese dioxide. Ammonium fuel was supplied to the compost soil ammonium fuel cell (CS-AFC) at concentrations of 0.1, 0.2, and 0.3 g/mL. The overall results show that ferricyanide affords a maximum power density of 1785.20 mW/m2 at 0.2 g/mL fuel concentration. This study focuses on high-power generation for CS-AFC. CS-AFCs are sustainable for many hours without any catalyst deactivation; however, they need to be refueled at regular intervals (every 12 h). Moreover, CS-AFCs afford the best performance when ferricyanide is used as the electron acceptor at the cathode. This study proposes a cheap electrocatalyst and possible solutions to the more serious energy generation problems. This study will help in recycling ammonium-rich wastewaters as free fuel for running CS-AFC devices to yield high-power generation with reducing agents for ammonium fuel cell power applications.

ABSTRACT The Helicobacter pylori type IV secretion system (T4SS) encoded on the cag pathogenicity island (cagPAI) secretes the CagA oncoprotein and other effectors into the gastric epithelium. During murine infection, T4SS function is lost in an immune-dependent manner, typically as a result of in-frame recombination in the middle repeat region of cagY, though single nucleotide polymorphisms (SNPs) in cagY or in other essential genes may also occur. Loss of T4SS function also occurs in gerbils, nonhuman primates, and humans, suggesting that it is biologically relevant and not simply an artifact of the murine model. Here, we sought to identify physiologically relevant conditions under which T4SS function is maintained in the murine model. We found that loss of H. pylori T4SS function in mice was blunted by systemic Salmonella coinfection and completely eliminated by dietary iron restriction. Both have epidemiologic parallels in humans, since H. pylori strains from individuals in developing countries, where iron deficiency and systemic infections are common, are also more often cagPAI+ than strains from developed countries. These results have implications for our fundamental understanding of the cagPAI and also provide experimental tools that permit the study of T4SS function in the murine model. IMPORTANCE The type IV secretion system (T4SS) is the major Helicobacter pylori virulence factor, though its function is lost during murine infection. Loss of function also occurs in gerbils and in humans, suggesting that it is biologically relevant, but the conditions under which T4SS regulation occurs are unknown. Here, we found that systemic coinfection with Salmonella and iron deprivation each promote retention of T4SS function. These results improve our understanding of the cag pathogenicity island (cagPAI) and provide experimental tools that permit the study of T4SS function in the murine model.

Abstract We study the behaviour of abelian gauge symmetries in six-dimensional N = (1,0) theories upon decoupling gravity and investigate abelian flavour symmetries in the context of 6d N = (1, 0) SCFTs. From a supergravity perspective, the anomaly cancellation mechanism implies that abelian gauge symmetries can only survive as global symmetries as gravity is decoupled. The flavour symmetries obtained in this way are shown to be free of ABJ anomalies, and their ’t Hooft anomaly polynomial in the decoupling limit is obtained explicitly. In an F-theory realisation the decoupling of abelian gauge symmetries implies that a mathematical object known as the height pairing of a rational section is not contractible as a curve on the base of an elliptic Calabi-Yau threefold. We prove this prediction from supergravity by making use of the properties of the Mordell-Weil group of rational sections. In the second part of this paper we study the appearance of abelian flavour symmetries in 6d N = (1, 0) SCFTs. We elucidate both the geometric origin of such flavour symmetries in F-theory and their field theoretic interpretation in terms of suitable linear combinations of geometrically massive U(1)s. Our general results are illustrated in various explicit examples.

Abstract We test various conjectures about quantum gravity for six-dimensional string compactifications in the framework of F-theory. Starting with a gauge theory coupled to gravity, we analyze the limit in Kähler moduli space where the gauge coupling tends to zero while gravity is kept dynamical. We show that such a limit must be located at infinite distance in the moduli space. As expected, the low-energy effective theory breaks down in this limit due to a tower of charged particles becoming massless. These are the excitations of an asymptotically tensionless string, which is shown to coincide with a critical heterotic string compactified to six dimensions. For a more quantitative analysis, we focus on a U(1) gauge symmetry and use a chain of dualities and mirror symmetry to determine the elliptic genus of the nearly tensionless string, which is given in terms of certain meromorphic weak Jacobi forms. Their modular properties in turn allow us to determine the charge-to-mass ratios of certain string excitations near the tensionless limit. We then provide evidence that the tower of asymptotically massless charged states satisfies the (sub-)Lattice Weak Gravity Conjecture, the Completeness Conjecture, and the Swampland Distance Conjecture. Quite remarkably, we find that the number theoretic properties of the elliptic genus conspire with the balance of gravitational and scalar forces of extremal black holes, such as to produce a narrowly tuned charge spectrum of superextremal states. As a byproduct, we show how to compute elliptic genera of both critical and non-critical strings, when refined by Mordell-Weil U(1) symmetries in F-theory.

Abstract In this work we systematically enumerate genus one fibrations in the class of 7, 890 Calabi-Yau manifolds defined as complete intersections in products of projective spaces, the so-called CICY threefolds. This survey is independent of the description of the manifolds and improves upon past approaches that probed only a particular algebraic form of the threefolds (i.e. searches for “obvious” genus one fibrations as in [1, 2]). We also study K3-fibrations and nested fibration structures. That is, K3 fibrations with potentially many distinct elliptic fibrations. To accomplish this survey a number of new geometric tools are developed including a determination of the full topology of all CICY threefolds, including triple intersection numbers. In 2, 946 cases this involves finding a new “favorable” description of the manifold in which all divisors descend from a simple ambient space. Our results consist of a survey of obvious fibrations for all CICY threefolds and a complete classification of all genus one fibrations for 4, 957 “Kähler favorable” CICYs whose Kähler cones descend from a simple ambient space. Within the CICY dataset, we find 139, 597 obvious genus one fibrations, 30, 974 obvious K3 fibrations and 208, 987 nested combinations. For the Kähler favorable geometries we find a complete classification of 377, 559 genus one fibrations. For one manifold with Hodge numbers (19, 19) we find an explicit description of an infinite number of distinct genus-one fibrations extending previous results for this particular geometry that have appeared in the literature. The data associated to this scan is available here [3].

Abstract We revisit the D0 bound state problems, of the M/IIA duality, with the Orientifolds. The cases of O4 and O8 have been studied recently, from the perspective of five-dimensional theories, while the case of O0 has been much neglected. The computation we perform for D0-O0 states boils down to the Witten indices for N = 16 $$ \mathcal{N}=16 $$ O(m) and Sp(n) quantum mechanics, where we adapt and extend previous analysis by the authors. The twisted partition function Ω, obtained via localization, proves to be rational, and we establish a precise relation between Ω and the integral Witten index ℐ, by identifying continuum contributions sector by sector. The resulting Witten index shows surprisingly large numbers of threshold bound states but in a manner consistent with M-theory. We close with an exploration on how the ubiquitous rational invariants of the wall-crossing physics would generalize to theories with Orientifolds.

We use the latest techniques in machine-learning to study whether from the landscape of Calabi-Yau manifolds one can distinguish elliptically fibred ones. Using the dataset of complete intersections in products of projective spaces (CICY3 and CICY4, totalling about a million manifolds) as a concrete playground, we find that a relatively simple neural network with forward-feeding multi-layers can very efficiently distinguish the elliptic fibrations, much more so than using the traditional methods of manipulating the defining equations. We cross-check with control cases to ensure that the AI is not randomly guessing and is indeed identifying an inherent structure. Our result should prove useful in F-theory and string model building as well as in pure algebraic geometry.

Nucleotide excision repair (NER) is an essential DNA repair system distinguished from other such systems by its extraordinary versatility. NER removes a wide variety of structurally dissimilar lesions having only their bulkiness in common. NER can also repair several less bulky nucleobase lesions, such as 8-oxoguanine. Thus, how a single DNA repair system distinguishes such a diverse array of structurally divergent lesions from undamaged DNA has been one of the great unsolved mysteries in the field of genome maintenance. Here we employ a synthetic crystallography approach to obtain crystal structures of the pivotal NER enzyme UvrB in complex with duplex DNA, trapped at the stage of lesion-recognition. These structures coupled with biochemical studies suggest that UvrB integrates the ATPase-dependent helicase/translocase and lesion-recognition activities. Our work also conclusively establishes the identity of the lesion-containing strand and provides a compelling insight to how UvrB recognizes a diverse array of DNA lesions.

CCL2/CCR2 signaling is believed to play an important role in kidney diseases. Several studies have demonstrated that blocking of CCR2 has a therapeutic effect on kidney diseases. However, the effects of CCR2 knockout on obesity-induced kidney injury remain unclear. We investigated the therapeutic effects and the mechanism of CCL2/CCR2 signaling in obesity-induced kidney injury. We used C57BL/6-CCR2 wild type and C57BL/6-CCR2 knockout mice: Regular diet wild type (RD WT), RD CCR2 knockout (RD KO), High-fat diet WT (HFD WT), HFD CCR2 KO (HFD KO). Body weight of WT mice was significantly increased after HFD. However, the body weight of HFD KO mice was not decreased compared to HFD WT mice. Food intake and calorie showed no significant differences between HFD WT and HFD KO mice. Glucose, insulin, total cholesterol, and triglycerides levels increased in HFD WT mice were decreased in HFD KO mice. Insulin resistance, increased insulin secretion, and lipid accumulation showed in HFD WT mice were improved in HFD KO mice. Increased desmin expression, macrophage infiltration, and TNF-α in HFD mice were reduced in HFD KO mice. HFD-induced albuminuria, glomerular hypertrophy, glomerular basement membrane thickening, and podocyte effacement were restored by CCR2 depletion. HFD-induced elevated expressions of xBP1, Bip, and Nox4 at RNA and protein levels were significantly decreased in HFD KO. Therefore, blockade of CCL2/CCR2 signaling by CCR2 depletion might ameliorate obesity-induced albuminuria through blocking oxidative stress, ER stress, and lipid accumulation.

Conventional categorical data imputation techniques, such as mode imputation, often encounter issues related to overestimation. If the variable has too many categories, multinomial logistic regression imputation method may be impossible due to computational limitations. To rectify these limitations, we propose a two-stage imputation method. During the first stage, we utilize the Boruta variable selection method on the complete dataset to identify significant variables for the target categorical variable. Then, in the second stage, we use the important variables for the target categorical variable for logistic regression to impute missing data in binary variables, polytomous regression to impute missing data in categorical variables, and predictive mean matching to impute missing data in quantitative variables. Through analysis of both asymmetric and non-normal simulated and real data, we demonstrate that the two-stage imputation method outperforms imputation methods lacking variable selection, as evidenced by accuracy measures. During the analysis of real survey data, we also demonstrate that our suggested two-stage imputation method surpasses the current imputation approach in terms of accuracy. [ABSTRACT FROM AUTHOR]

The Wnt/β-catenin signaling pathway plays a major role in tissue homeostasis, and its dysregulation can lead to various human diseases. Aberrant activation of β-catenin is oncogenic and is a critical driver in the development and progression of human cancers. Despite the significant potential of targeting the oncogenic β-catenin pathway for cancer therapy, the development of specific inhibitors remains insufficient. Using a T cell factor (TCF)-dependent luciferase-reporter system, we screened for small-molecule compounds that act against Wnt/β-catenin signaling and identified MSAB (methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate) as a selective inhibitor of Wnt/β-catenin signaling. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. Our findings might represent an effective therapeutic strategy for cancers addicted to the Wnt/β-catenin signaling pathway.

We present a generalization of the complete intersection in products of projective space (CICY) construction of Calabi–Yau manifolds. CICY three-folds and four-folds have been studied extensively in the physics literature. Their utility stems from the fact that they can be simply described in terms of a ‘configuration matrix’, a matrix of integers from which many of the details of the geometries can be easily extracted. The generalization we present is to allow negative integers in the configuration matrices which were previously taken to have positive semi-definite entries. This broadening of the complete intersection construction leads to a larger class of Calabi–Yau manifolds than that considered in previous work, which nevertheless enjoys much of the same degree of calculational control. These new Calabi–Yau manifolds are complete intersections in (not necessarily Fano) ambient spaces with an effective anticanonical class. We find examples with topology distinct from any that has appeared in the literature to date. The new manifolds thus obtained have many interesting features. For example, they can have smaller Hodge numbers than ordinary CICYs and lead to many examples with elliptic and K3-fibration structures relevant to F-theory and string dualities.

Purpose: The previous reports regarding VUR resolution were not precise due to early frequent surgical intervention. We evaluated the spontaneous resolution (SR) rate and the incidence of new renal scars in primary VUR, focusing on severe reflux. Methods: Medical records of 334 patients with primary VUR who were on medical prophylaxis without surgery for 1 to 9 years, were retrospectively reviewed. Medical prophylaxis was initiated with low-dose antibiotic prophylaxis or probiotics. Radioisotope cystourethrography was performed every 1 to 3 years until SR of reflux. New renal scar was evaluated with follow-up 99mTc DMSA renal scan. Results: The SR rates decreased as VUR grades were getting higher (P =0.00). The overall and annual SR were 58.4% and 14.9%/yr in grade IV reflux and 37.5% and 9.3%/yr in grade V reflux. The median times of SR were 38 months in grade IV reflux and 66 months in grade V reflux. The probable SR rates in grade IV and V reflux were 7.8% and 8.9% in the 1st year, 46.0% and 30.8% in the 3rd year and 74.4% and 64.4% in the 5th year. The incidences of new renal scars between low to moderate reflux and severe reflux showed no significant difference (P =0.32). Conclusion: The SR rates of severe primary VUR were higher than previously reported and most new renal scars were focal and mild.

Volatile compositions and sensory characteristics of 11 commercially distilled soju samples were investigated using headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) and sensory descriptive analysis. A total of 59 major volatile compounds, consisting of 32 esters, 10 alcohols, 2 acids, 5 aldehydes, 3 ketones, 1 hydrocarbon, 1 furan, 2 phenols, and 3 miscellaneous compounds, were identified. From the principal component analysis (PCA) of volatile data, MSJ made by atmospheric distillation showed a clear distinction in volatile compositions compared to that of other samples made by vacuum distillation. Based on PCA of the sensory data determined by a panel of ten judges, MSJ was associated with a large amount of longer chain esters that showed high intensities in bitter taste and yeast/nuruk-related flavor attributes. HYJ, LPJ, and HAJ made with rice as a raw material were associated with lower intensities of the alcohol aroma, while JRJ and OKJ aged in oak barrels were associated with fruit flavor, sweet flavor, and brandy aroma. In the partial least squares regression (PLSR) analysis to see any relationship between volatile and sensory data, longer chain esters like ethyl tetradecanoate, and ethyl hexadecanoate were highly associated with bleach aroma. In contrast, positive correlations were seen with barley aroma and yeast flavor with hexanal, nonanal, benzaldehyde, and 2-methoxy-phenol.

To revise the clinical guideline for childhood urinary tract infections (UTIs) of the Korean Society of Pediatric Nephrology (2007), the recently updated guidelines and new data were reviewed.The major revisions are as follows. In diagnosis, the criterion for a positive culture of the catheterized or suprapubic aspirated urine is reduced to 50,000 colony forming uits (CFUs)/mL from 100,000 CFU/mL. Diagnosis is more confirmatory if the urinalysis is abnormal. In treating febrile UTI and pyelonephritis, oral antibiotics is considered to be as effective as parenteral antibiotics. In urologic imaging studies, the traditional aggressive approach to find primary vesicoureteral reflux (VUR) and renal scar is shifted to the targeted restrictive approach. A voiding cystourethrography is not routinely recommended and is indicated only in atypical or complex clinical conditions, abnormal ultrasonography and recurrent UTIs. 99mTc-DMSA renal scan is valuable in diagnosing pyelonephritis in children with negative culture or normal RBUS. Although it is not routinely recommended, normal scan can safely avoid VCUG. In prevention, a more natural approach is preferred. Antimicrobial prophylaxis is not supported any more even in children with VUR. Topical steroid (2-4 weeks) to non-retractile physiologic phimosis or labial adhesion is a reasonable first-line treatment. Urogenital hygiene is important and must be adequately performed. Breast milk, probiotics and cranberries are dietary factors to prevent UTIs. Voiding dysfunction and constipation should be properly treated and prevented by initiating toilet training at an appropriate age (18-24 months). The follow-up urine test on subsequent unexplained febrile illness is strongly recommended. Changes of this revision is not exclusive and appropriate variation still may be accepted.