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Your search keyword '"Setiadi, A. Francesca"' showing total 17 results
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17 results on '"Setiadi, A. Francesca"'

1. Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Author

Yadav, Rajbharan, Sukumaran, Siddharth, Lutman, Jeff, Mitra, Mayur S., Halpern, Wendy, Sun, Tianhe, Setiadi, A. Francesca, Neighbors, Margaret, Sheng, X. Rebecca, Yip, Victor, Shen, Ben-Quan, Liu, Chang, Han, Lyrialle, Ovacik, Ayse Meric, Wu, Yan, Glickstein, Sara, Kunder, Rebecca, Arron, Joseph R., Pan, Lin, Kamath, Amrita V., and Stefanich, Eric G. more...

Published
2023
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6. The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

Author

Corzo, Cesar A., primary, Varfolomeev, Eugene, additional, Setiadi, A. Francesca, additional, Francis, Ross, additional, Klabunde, Sha, additional, Senger, Kate, additional, Sujatha-Bhaskar, Swathi, additional, Drobnick, Joy, additional, Do, Steven, additional, Suto, Eric, additional, Huang, Zhiyu, additional, Eastham-Anderson, Jeffrey, additional, Katewa, Arna, additional, Pang, Jodie, additional, Domeyer, Melanie, additional, Dela Cruz, Christopher, additional, Paler-Martinez, Andres, additional, Lau, Vivian W. C., additional, Hadadianpour, Azadeh, additional, Ramirez-Carrozi, Vladimir, additional, Sun, Yonglian, additional, Bao, Katherine, additional, Xu, Daqi, additional, Hunley, Emily, additional, Brightbill, Hans D., additional, Warming, Soren, additional, Roose-Girma, Merone, additional, Wong, Alfred, additional, Tam, Lucinda, additional, Emson, Claire L., additional, Crawford, James J., additional, Young, Wendy B., additional, Pappu, Rajita, additional, McKenzie, Brent S., additional, Asghari, Vida, additional, Vucic, Domagoj, additional, Hackney, Jason A., additional, Austin, Cary D., additional, Lee, Wyne P., additional, Lekkerkerker, Annemarie, additional, Ghilardi, Nico, additional, Bryan, Marian C., additional, Kiefer, James R., additional, Townsend, Michael J., additional, and Zarrin, Ali A., additional more...

Published
2020
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7. Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

Author

Humby, Frances, Lewis, Myles, Ramamoorthi, Nandhini, Hackney, Jason A, Barnes, Michael R, Bombardieri, Michele, Setiadi, A. Francesca, Kelly, Stephen, Bene, Fabiola, DiCicco, Maria, Riahi, Sudeh, Rocher, Vidalba, Ng, Nora, Lazarou, Ilias, Hands, Rebecca, van der Heijde, Désirée, Landewé, Robert B M, van der Helm-van Mil, Annette, Cauli, Alberto, McInnes, Iain, Buckley, Christopher Dominic, Choy, Ernest H, Taylor, Peter C, Townsend, Michael J, Pitzalis, Costantino, Clinical Immunology and Rheumatology, and AII - Inflammatory diseases more...

Subjects
dmards (synthetic), inflammation, early rheumatoid arthritis, Rheumatoid Arthritis, synovitis
Abstract

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally. Methods 144 consecutive treatment-naïve early RA patients ( Results Cellular and molecular analyses of synovial tissue demonstrated for the first time in early RA the presence of three pathology groups: (1) lympho-myeloid dominated by the presence of B cells in addition to myeloid cells; (2) diffuse-myeloid with myeloid lineage predominance but poor in B cells nd (3) pauci-immune characterised by scanty immune cells and prevalent stromal cells. Longitudinal correlation of molecular signatures demonstrated that elevation of myeloid- and lymphoid-associated gene expression strongly correlated with disease activity, acute phase reactants and DMARD response at 6 months. Furthermore, elevation of synovial lymphoid-associated genes correlated with autoantibody positivity and elevation of osteoclast-targeting genes predicting radiographic joint damage progression at 12 months. Patients with predominant pauci-immune pathology showed less severe disease activity and radiographic progression. Conclusions We demonstrate at disease presentation, prior to pathology modulation by therapy, the presence of specific cellular/molecular synovial signatures that delineate disease severity/progression and therapeutic response and may pave the way to more precise definition of RA taxonomy, therapeutic targeting and improved outcomes. more...

Published
2019
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9. The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Author

Senger, Kate, primary, Pham, Victoria C., additional, Varfolomeev, Eugene, additional, Hackney, Jason A., additional, Corzo, Cesar A., additional, Collier, Jenna, additional, Lau, Vivian W. C., additional, Huang, Zhiyu, additional, Hamidzhadeh, Kajal, additional, Caplazi, Patrick, additional, Peng, Ivan, additional, Setiadi, A. Francesca, additional, Francis, Ross, additional, Paler-Martinez, Andres, additional, Kwon, Youngsu C., additional, Ramirez-Carrozzi, Vladimir, additional, Sun, Yonglian, additional, Grigg, Patricia W., additional, Roose-Girma, Merone, additional, Jeet, Surinder, additional, Barck, Kai H., additional, Pham, Anna, additional, Ota, Naruhisa, additional, Ha, Connie, additional, Stinson, Jeremy, additional, Guillory, Joseph, additional, Tam, Lucinda, additional, Modrusan, Zora, additional, Emson, Claire, additional, McKenzie, Brent S., additional, Townsend, Michael J., additional, Carano, Richard A. D., additional, Warming, Søren, additional, Vucic, Domagoj, additional, DeVoss, Jason, additional, Lee, Wyne P., additional, Lill, Jennie R., additional, and Zarrin, Ali A., additional more...

Published
2017
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11. Mechanisms underlying the downregulation of the transporter associated with antigen processing (TAP)-1 in carcinomas

Author

Setiadi, Alvernia Francesca

Abstract

Expression of Transporter associated with Antigen Processing (TAP)-1 is often lost in metastatic carcinomas, resulting in defective antigen processing and presentation, and escape of the cancer cell from immune surveillance. In this study, the nature of TAP-1 deficiencies in tumors was investigated. By chromatin immunoprecipitation assay, it was shown that the recruitment of RNA polymerase II to the Tap-1 gene was impaired in TAP-deficient, metastatic cells derived from murine melanoma, prostate and lung carcinomas. Levels of TAP-1 promoter activity, as assessed by stable transfections with a reporter construct containing the TAP-1 promoter, were also relatively low in TAP-deficient cells. These suggest that the deficiency in TAM expression resulted--at least partially--from a reduced level of transcriptional activity of the Tap-1 gene. In order to examine genetic heritability of regulators of TAP-1 promoter activity, TAP- and MHC class I-deficient cells of H-2[sup b] origin were fused with wild-type fibroblasts of H-2[sup k] origin. Fusion with TAP-expressing cells complemented the low levels of TAP-1 promoter activity in TAP-deficient cells. However, these fused cells exhibited lower levels of TAP-1 mRNA and H-2[sup k] than unfused fibroblasts. Further analysis showed that TAP-1 mRNA stability was lower in fused carcinoma-fibroblasts than in unfused fibroblasts. Taken together, TAP deficiency in many carcinomas appears to be caused by a decrease in activity/expression of trans-acting factors regulating TAP-1 promoter activity, as well as a decrease in TAP-1 mRNA stability. The hypothesis that epigenetic regulation plays a fundamental role in controlling TAP-1 transcription was also tested. Chromatin immunoprecipitation analyses showed that the lack of TAP-1 transcription correlated with low levels of recruitment of a histone acetyltransferase, CBP, and of histone H3 acetylation at the TAP-1 promoter, leading to a decrease in accessibility of the RNA polymerase II complex to the TAP-1 promoter. These findings lie at the heart of understanding immune escape mechanisms in tumors and suggest that the reversal of epigenetic codes may provide novel immunotherapeutic paradigms for intervention in cancer. more...

Published
2007
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12. Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

Author

Dennis, Glynn, primary, Holweg, Cécile TJ, additional, Kummerfeld, Sarah K, additional, Choy, David F, additional, Setiadi, A Francesca, additional, Hackney, Jason A, additional, Haverty, Peter M, additional, Gilbert, Houston, additional, Lin, Wei Yu, additional, Diehl, Lauri, additional, Fischer, S, additional, Song, An, additional, Musselman, David, additional, Klearman, Micki, additional, Gabay, Cem, additional, Kavanaugh, Arthur, additional, Endres, Judith, additional, Fox, David A, additional, Martin, Flavius, additional, and Townsend, Michael J, additional more...

Published
2014
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13. Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients

Author

Chang, Andrew Y, primary, Bhattacharya, Nupur, additional, Mu, Jian, additional, Setiadi, A Francesca, additional, Carcamo-Cavazos, Valeria, additional, Lee, Gerald H, additional, Simons, Diana L, additional, Yadegarynia, Sina, additional, Hemati, Kaveh, additional, Kapelner, Adam, additional, Ming, Zheng, additional, Krag, David N, additional, Schwartz, Erich J, additional, Chen, Danny Z, additional, and Lee, Peter P, additional more...

Published
2013
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14. Quantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes

Author

Setiadi, A. Francesca, primary, Ray, Nelson C., additional, Kohrt, Holbrook E., additional, Kapelner, Adam, additional, Carcamo-Cavazos, Valeria, additional, Levic, Edina B., additional, Yadegarynia, Sina, additional, van der Loos, Chris M., additional, Schwartz, Erich J., additional, Holmes, Susan, additional, and Lee, Peter P., additional more...

Published
2010
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