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1. Growth in children with nephrotic syndrome: a post hoc analysis of the NEPTUNE study

Author

Maniar, Aesha, Gipson, Debbie S., Brady, Tammy, Srivastava, Tarak, Selewski, David T., Greenbaum, Larry A., Dell, Katherine M., Kaskel, Frederick, Massengill, Susan, Tran, Cheryl, Trachtman, Howard, Lafayette, Richard, Almaani, Salem, Hingorani, Sangeeta, Wang, Chia-shi, Reidy, Kimberly, Cara-Fuentes, Gabriel, Gbadegesin, Rasheed, Myers, Kevin, and Sethna, Christine B.

Published
2024
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3. Longitudinal analysis of blood pressure and lipids in childhood nephrotic syndrome

Author

Carboni, Johnathon, Thomas, Elizabeth, Gipson, Debbie S., Brady, Tammy M., Srivastava, Tarak, Selewski, David T., Greenbaum, Larry A., Wang, Chia-shi, Dell, Katherine M., Kaskel, Frederick, Massengill, Susan, Reidy, Kimberly, Tran, Cheryl L., Trachtman, Howard, Lafayette, Richard, Almaani, Salem, Hingorani, Sangeeta, Gbadegesin, Rasheed, Gibson, Keisha L., and Sethna, Christine B.

Published
2024
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13. Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study

Author

Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Chan, Brenda, D’Agati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Jain, Namrata, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nestor, Jordan, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Mucha, Krzysztof, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Lugani, Francesca, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Isa Ashoor, Aviles, Diego, Srivastava, Tarak, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Gbadegesin, Rasheed, Gomez-Mendez, Liliana, Yin, Hong (Julie), Cai, Yi, Jens, Goebel, Steinke, Julia, Weaver, Donald, Lane, Jerome, Cramer, Carl, Pan, Cindy, Paloian, Neil, Sreedharan, Rajasree, Selewski, David, Twombley, Katherine, Bowers, Corinna, Dreher, Mary, Kallash, Mahmoud, Mahan, John, Sharpe, Samantha, Al-Uzri, Amira, Iragorri, Sandra, Belsha, Craig, Alge, Joseph, Braun, Michael, Gomez, A.C., Wenderfer, Scott, Vasylyeva, Tetyana, Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Chishti, Aftab, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Hunley, Tracy, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Peleg, Yonatan, Wadhwani, Shikha, Almaani, Salem, Ayoub, Isabelle, Nadasdy, Tibor, Parikh, Samir, Rovin, Brad, Chang, Anthony, Fatima, Huma, Julian, Bruce, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Chen, Dhruti, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Mottl, Amy, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Kidd, Jason, Muthusamy, Selvaraj, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, O’Toole, John, Sedor, John, Sethna, Christine, Vento, Suzanne, Atta, Mohamed, Bagnasco, Serena, Neu, Alicia, Sperati, John, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Brathwaite, Kaye, Reidy, Kimberly, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Kopp, Jeffrey, Waldman, Meryl, Winkler, Cheryl, Krissberg, Jill, Lafayette, Richard, Fahmeedah, Kamal, Talley, Elizabeth, Hladunewich, Michelle, Parekh, Rulan, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Blazius, Brooke, Hodgin, Jeffrey, Oliverio, Andrea, Hogan, Jon, Palmer, Matthew, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Roehm, Bethany, Graff, John, Gillespie, Brenda, Kretzler, Matthias, Nast, Cynthia, Barisoni, Laura, Guay-Woodford, Lisa M., Wang, Chia-shi, Glenn, Dorey A., Helmuth, Margaret, Smith, Abigail R., Bomback, Andrew S., Canetta, Pietro A., Coppock, Gaia M., Khalid, Myda, Tuttle, Katherine R., Bou-Matar, Raed, Greenbaum, Larry A., Robinson, Bruce M., Holzman, Lawrence B., Smoyer, William E., Rheault, Michelle N., Gipson, Debbie, and Mariani, Laura H.

Published
2024
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14. Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease

Author

Kogon, Amy J., Ballester, Lance S., Zee, Jarcy, Walker, Natalie, Zaritsky, Joshua J., Atkinson, Meredith A., Sethna, Christine B., Hoofnagle, Andrew N., Leonard, Mary B., and Denburg, Michelle R.

Subjects
Care and treatment, Usage, Health aspects, Pediatric research, Proteinuria -- Care and treatment, Pediatric diseases -- Care and treatment, Glomerulonephritis -- Care and treatment, Vitamin D -- Usage -- Health aspects, Dietary supplements -- Usage -- Health aspects, Children -- Diseases, Alfacalcidol -- Usage -- Health aspects, Calcifediol -- Usage -- Health aspects
Abstract

Author(s): Amy J. Kogon [sup.1] , Lance S. Ballester [sup.2] , Jarcy Zee [sup.3] , Natalie Walker [sup.1] , Joshua J. Zaritsky [sup.4] , Meredith A. Atkinson [sup.5] , Christine [...], Background Vitamin D deficiency is common in glomerular disease. Supplementation may be ineffective due to ongoing urinary losses of vitamin D binding protein. We sought to determine if daily cholecalciferol supplementation would increase vitamin D concentrations in children with glomerular disease and persistent proteinuria, without adverse effects. Methods Eighteen participants at least 5 years of age with primary glomerular disease and urine protein:creatinine ratio [greater than or equal to] 0.5 were enrolled from four pediatric nephrology practices to receive cholecalciferol supplementation: 4,000 IU or 2,000 IU per day for serum 25 hydroxyvitamin vitamin D (25OHD) concentrations < 20 ng/mL and 20 ng/mL to < 30 ng/mL, respectively. Measures of vitamin D and mineral metabolism were obtained at baseline and weeks 6 and 12. Multivariable generalized estimating equation (GEE) regression estimated mean percent changes in serum 25OHD concentration. Results Median baseline 25OHD was 12.8 ng/mL (IQR 9.3, 18.9) and increased to 27.8 ng/mL (20.5, 36.0) at week 6 (p 20 ng/mL. In the adjusted GEE model, 25OHD was 102% (95% CI: 64, 141) and 96% (95% CI: 51, 140) higher versus baseline at weeks 6 and 12, respectively (p < 0.001). Conclusion Cholecalciferol supplementation in vitamin D deficient children with glomerular disease and persistent proteinuria safely increases 25OHD concentration. Ideal dosing to fully replete 25OHD concentrations in this population remains unknown. Clinical trial NCT01835639. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

Published
2023
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16. The Significance of Hematuria in Podocytopathies

Author

Marchel, Dorota, Trachtman, Howard, Larkina, Maria, Helmuth, Margaret, Lai Yee, Jennifer Y., Fermin, Damian, Bomback, Andrew S., Canetta, Pietro A., Gipson, Debbie S., Mottl, Amy K., Parekh, Rulan S., Saha, Manish K., Sampson, Matthew G., Lafayette, Richard A., Mariani, Laura H., Massengill, S., Lo, L., Dell, K., Sedor, J., Martin, B., Lemley, K., Fajardo, C., Sharma, S., Srivastava, T., Markus, K., Sethna, C., Vento, S., Canetta, P., Pradhan, A., Gbadegesin, R., Olabisi, O., Smith, M., Greenbaum, L., Wang, C.S., Yun, E., Adler, S., LaPage, J., Amarah, A., Itteera, M., Atkinson, M., Williams, M., Fervenza, F., Hogan, M., Lieske, J., Selewski, D., Alston, C., Kaskel, F., Ross, M., Flynn, P., Kopp, J., Malaga-Dieguez, L., Zhdanova, O., Pehrson, L.J., Almaani, S., Roberts, L., Lafayette, R., Dave, S., Lee, I., Pfeffer, Z., Shah, S., Deslandes, A., Reich, H., Hladunewich, M., Ling, P., Romano, M., Brakeman, P, Podoll, A., Rogers, N., McCarthy, E., Landry, E., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., Stelzer, M., Nachman, P., Rheault, M., Rao, V., Derebail, V., Gibson, K., Froment, A., Ochoa-Toro, F., Holzman, L., Meyers, K., Kallem, K., Swenson, A., Sharma, K., Sambandam, K., Robles, E., Turk, M., Jefferson, A., Hingorani, S., Tuttle, K., Manahan, L., Pao, E., Kuykendall K, K., Lin, J.J., Cody, E., Kretzler, M., Barisoni, L., Gadegbeku, C., Gillespie, B., Gipson, D., Holzman, L., Mariani, L., Sampson, M.G., Sedor, J., Smith, A., Zee, J., Alter, G., Desmond, H., Eddy, S., Fermin, D., Ju, W., Larkina, M., Li, S., Lienczewski, C.C., Mainieri, T., Scherr, R., Troost, J., Williams, A., Wang, Y., Avila-Casado, Carmen, Bagnasco, Serena, Cassol, Clarissa, Bu, Lihong, Caltharp, Shelley, Demeke, Dawit, Gillespie, Brenda, Hassler, Jared, Herlitz, Leal, Hewitt, Stephen, Hodgin, Jeff, Holanda, Danni, Kambham, Neeraja, Lemley, Kevin, Mariani, Laura, Messias, Nidia, Mikhailov, Alexei, Najafian, Behzad, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Stokes, Barry, Thomas, David, Yamashita, Michifumi, Yin, Hong, Zee, Jarcy, Zuo, Yiqin, Barisoni, Laura, Nast, Cynthia, Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Bomback, Andrew, Canetta, Pietro, Chan, Brenda, DʼAgati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Jain, Namrata, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nestor, Jordan, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Mucha, Krzysztof, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Lugani, Francesca, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Ashoor, Isa, Aviles, Diego, Srivastava, Tarak, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Gbadegesin, Rasheed, Gomez-Mendez, Liliana, Greenbaum, Larry, Wang, Chia-shi, Yin, Hong (Julie), Cai, Yi, Jens, Goebel, Steinke, Julia, Weaver, Donald, Lane, Jerome, Cramer, Carl, Pan, Cindy, Paloian, Neil, Sreedharan, Rajasree, Selewski, David, Twombley, Katherine, Bowers, Corinna, Dreher, Mary, Kallash, Mahmoud, Mahan, John, Sharpe, Samantha, Smoyer, William, Al-Uzri, Amira, Iragorri, Sandra, Khalid, Myda, Belsha, Craig, Alge, Joseph, Braun, Michael, Gomez, AC, Wenderfer, Scott, Vasylyeva, Tetyana, Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Chishti, Aftab, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Rheault, Michelle, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Hunley, Tracy, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Peleg, Yonatan, Wadhwani, Shikha, Almaani, Salem, Ayoub, Isabelle, Nadasdy, Tibor, Samir, Parikh, Rovin, Brad, Chang, Anthony, Fatima, Huma, Julian, Bruce, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Chen, Dhruti, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Glenn, Dorey, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Mottl, Amy, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Kidd, Jason, Muthusamy, Selvaraj, Schelling, Jeffrey, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, Matar, Raed Bou, OʼToole, John, Sedor, John, Sethna, Christine, Vento, Suzanne, Atta, Mohamed, Bagnasco, Serena, Neu, Alicia, Sperati, John, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Brathwaite, Kaye, Reidy, Kimberly, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Kopp, Jeffrey, Waldman, Meryl, Winkler, Cheryl, Tuttle, Katherine, Krissberg, Jill, Lafayette, Richard, Fahmeedah, Kamal, Talley, Elizabeth, Hladunewich, Michelle, Parekh, Rulan, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Gipson, Patrick, Hodgin, Jeffrey, Oliverio, Andrea, Hogan, Jon, Holzman, Lawrence, Palmer, Matthew, Coppock, Gaia, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Roehm, Bethany, Smith, Abigail, Nast, Cynthia, Barisoni, Laura, Gillespie, Brenda, Robinson, Bruce, Kretzler, Matthias, Mariani, Laura, and Guay-Woodford, Lisa M.

Published
2024
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19. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease

Author

Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Bomback, Andrew, Brown, Eric, Canetta, Pietro, Carlassara, Lucrezia, Chan, Brenda, D’Agati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Mucha, Krzysztof, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Ashoor, Isa, Srivastava, Tarak, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Silva, Cynthia, Gomez-Mendez, Liliana, Wang, Chia-shi, Yin, Hong (Julie), Jens, Goebel, Steinke, Julia, Cramer, Carl, Pan, Cindy, Sreedharan, Rajasree, Bowers, Corinna, Dreher, Mary, Kallash, Mahmoud, Mahan, John, Sharpe, Samantha, Smoyer, William, Al-Uzri, Amira, Belsha, Craig, Braun, Michael, Gomez, A.C., Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Chishti, Aftab, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Rheault, Michelle, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Hunley, Tracy, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Wadhwani, Shikha, Ayoub, Isabelle, Nadasdy, Tibor, Parikh, Samir, Rovin, Brad, Chang, Anthony, Fatima, Huma, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Chen, Dhruti, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Mottl, Amy, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Kidd, Jason, Massey, Hugh, Muthusamy, Selvaraj, Ganesan, Santhi, Gonzalez-Vicente, Agustin, Schelling, Jeffrey, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, Matar, Raed Bou, O’Toole, John, Sedor, John, Bagnasco, Serena, Neu, Alicia, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Vento, Suzanne, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Waldman, Meryl, Winkler, Cheryl, Hladunewich, Michelle, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Gipson, Patrick, Hodgin, Jeffrey, Oliverio, Andrew, Hogan, Jon, Holzman, Lawrence, Palmer, Matthew, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Robinson, Bruce, Nast, Cynthia, Barisoni, Laura, Gillespie, Brenda, Gipson, Deb, Hicken, Maggie, Kretzler, Matthias, Mariani, Laura, Guay-Woodford, Lisa M., Krissberg, Jill R., O’Shaughnessy, Michelle M., Smith, Abigail R., Helmuth, Margaret E., Almaani, Salem, Aviles, Diego H., Brathwaite, Kaye E., Cai, Yi, Gbadegesin, Rasheed, Glenn, Dorey A., Greenbaum, Larry A., Iragorri, Sandra, Khalid, Myda, Kopp, Jeffrey, Lafayette, Richard, Lane, Jerome C., Lugani, Francesca, Nestor, Jordan G., Parekh, Rulan S., Reidy, Kimberly, Selewski, David T., Sethna, Christine B., Sperati, C. John, Tuttle, Katherine, Twombley, Katherine, Vasylyeva, Tetyana L., Weaver, Donald J., Jr., and Wenderfer, Scott E.

Published
2023
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20. Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis

Author

Mariani, Laura H., Eddy, Sean, AlAkwaa, Fadhl M., McCown, Phillip J., Harder, Jennifer L., Nair, Viji, Eichinger, Felix, Martini, Sebastian, Ademola, Adebowale D., Boima, Vincent, Reich, Heather N., El Saghir, Jamal, Godfrey, Bradley, Ju, Wenjun, Tanner, Emily C., Vega-Warner, Virginia, Wys, Noel L., Adler, Sharon G., Appel, Gerald B., Athavale, Ambarish, Atkinson, Meredith A., Bagnasco, Serena M., Barisoni, Laura, Brown, Elizabeth, Cattran, Daniel C., Coppock, Gaia M., Dell, Katherine M., Derebail, Vimal K., Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal A., Gibson, Keisha L., Greenbaum, Laurence A., Hingorani, Sangeeta R., Hladunewich, Michelle A., Hodgin, Jeffrey B., Hogan, Marie C., Holzman, Lawrence B., Jefferson, J. Ashley, Kaskel, Frederick J., Kopp, Jeffrey B., Lafayette, Richard A., Lemley, Kevin V., Lieske, John C., Lin, Jen-Jar, Menon, Rajarasee, Meyers, Kevin E., Nachman, Patrick H., Nast, Cynthia C., O’Shaughnessy, Michelle M., Otto, Edgar A., Reidy, Kimberly J., Sambandam, Kamalanathan K., Sedor, John R., Sethna, Christine B., Singer, Pamela, Srivastava, Tarak, Tran, Cheryl L., Tuttle, Katherine R., Vento, Suzanne M., Wang, Chia-shi, Ojo, Akinlolu O., Adu, Dwomoa, Gipson, Debbie S., Trachtman, Howard, and Kretzler, Matthias

Published
2023
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24. Diagnosis, Treatment, and Outcomes in Children With Congenital Nephrogenic Diabetes Insipidus: A Pediatric Nephrology Research Consortium Study.

Author

DAlessandri-Silva, Cynthia, Carpenter, Melinda, Ayoob, Rose, Barcia, John, Chishti, Aftab, Constantinescu, Alex, Dell, Katherine, Goodwin, Julie, Hashmat, Shireen, Iragorri, Sandra, Kaspar, Cristin, Mason, Sherene, Misurac, Jason, Muff-Luett, Melissa, Sethna, Christine, Shah, Shweta, Weng, Patricia, Greenbaum, Larry, and Mahan, John

Subjects
genetic disease, multicenter, nephrogenic diabetes insipidus (NDI), pediatric, vasopressin (AVP)
Abstract

Background and Objectives: Congenital or primary nephrogenic diabetes insipidus (NDI) is a rare genetic disorder that severely impairs renal concentrating ability, resulting in massive polyuria. There is limited information about prognosis or evidence guiding the management of these patients, either in the high-risk period after diagnosis, or long-term. We describe the clinical presentation, genetic etiology, treatment and renal outcomes in a large group of children

Published
2019

25. Acute kidney injury and kidney recovery after cardiopulmonary bypass in children

Author

LoBasso, Michael, Schneider, James, Sanchez-Pinto, L. Nelson, Del Castillo, Sylvia, Kim, Gina, Flynn, Alysia, and Sethna, Christine B.

Subjects
Children -- Diseases, Acute renal failure -- Diagnosis -- Risk factors -- Prognosis, Cardiopulmonary bypass -- Complications and side effects, Acute renal failure in children -- Diagnosis -- Risk factors -- Prognosis, Health
Abstract

Background Acute kidney injury (AKI) that improves in the pediatric intensive care unit (PICU) is associated with better outcomes compared to AKI that persists, but no study has investigated whether this also occurs in children undergoing cardiopulmonary bypass (CPB). Methods A retrospective study of children [less than or equal to]18 years who underwent CPB in three children's hospitals was conducted. Patients were classified into groups by kidney recovery after AKI according to Acute Disease Quality Initiative (ADQI) guidelines. Adjusted regression models evaluated associations between kidney recovery group and hospital outcomes. Results Among 3620 children, AKI developed in 701 (19.4%): 610 transient AKI, 47 persistent AKI, and 44 acute kidney disease (AKD). Mortality increased with severity of kidney recovery group: 4.5% in the never developed AKI group, 8.9% in the transient AKI group, 25.5% in the persistent AKI group, and 31.8% in the AKD group (p Conclusions Patterns of kidney recovery after AKI were associated with worse PICU outcomes in children after CPB compared to those who did not develop AKI, even after rapid AKI recovery. Identification of factors that increase risk for these AKI patterns is necessary for prevention of AKI during CPB in children. Graphical abstract, Author(s): Michael LoBasso [sup.1] , James Schneider [sup.2] , L. Nelson Sanchez-Pinto [sup.3] , Sylvia Del Castillo [sup.4] , Gina Kim [sup.4] , Alysia Flynn [sup.4] , Christine B. Sethna [...]

Published
2022
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29. Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation

Author

Bomback, Andrew S., Appel, Gerald B., Gipson, Debbie S., Hladunewich, Michelle A., Lafayette, Richard, Nester, Carla M., Parikh, Samir V., Smith, Richard J.H., Trachtman, Howard, Heeger, Peter S., Ram, Sanjay, Rovin, Brad H., Ali, Shadab, Arceneaux, Nicole, Ashoor, Isa, Bailey-Wickins, Laura, Barratt, Jonathan, Beck, Laurence, Cattran, Daniel C., Cravedi, Paolo, Erkan, Elif, Fervenza, Fernando, Frazer-Abel, Ashley A., Fremeaux-Bacchi, Veronique, Fuller, Lindsey, Gbadegesin, Rasheed, Hogan, Jonathan J., Kiryluk, Krzysztof, le Quintrec-Donnette, Moglie, Licht, Christoph, Mahan, John D., Pickering, Matthew C., Quigg, Richard, Rheault, Michelle, Ronco, Pierre, Sarwal, Minnie M., Sethna, Christine, Spino, Cathie, Stegall, Mark, Vivarelli, Marina, Feldman, David L., and Thurman, Joshua M.

Published
2022
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32. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis

Author

Zee, Jarcy, McNulty, Michelle T., Hodgin, Jeffrey B., Zhdanova, Olga, Hingorani, Sangeeta, Jefferson, Jonathan Ashley, Gibson, Keisha L., Trachtman, Howard, Fornoni, Alessia, Dell, Katherine M., Reich, Heather N., Bagnasco, Serena, Greenbaum, Larry A., Lafayette, Richard A., Gipson, Debbie S., Brown, Elizabeth, Kretzler, Matthias, Appel, Gerald, Sambandam, Kamalanathan K., Tuttle, Katherine R., Chen, Dhruti, Atkinson, Meredith A., Hogan, Marie C., Kaskel, Frederick J., Meyers, Kevin E., O’Toole, John, Srivastava, Tarak, Sethna, Christine B., Hladunewich, Michelle A., Lin, JJ, Nast, Cynthia C., Derebail, Vimal K., Patel, Jiten, Vento, Suzanne, Holzman, Lawrence B., Athavale, Ambarish M., Adler, Sharon G., Lemley, Kevin V., Lieske, John C., Hogan, Jonathan J., Gadegbeku, Crystal A., Fervenza, Fernando C., Wang, Chia-Shi, Matar, Raed Bou, Singer, Pamela, Kopp, Jeffrey B., Barisoni, Laura, and Sampson, Matthew G.

Published
2021
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33. Acute kidney injury in pediatric patients hospitalized with acute COVID-19 and multisystem inflammatory syndrome in children associated with COVID-19

Author

Basalely, Abby, Gurusinghe, Shari, Schneider, James, Shah, Sareen S., Siegel, Linda B., Pollack, Gabrielle, Singer, Pamela, Castellanos-Reyes, Laura J., Fishbane, Steven, Jhaveri, Kenar D., Mitchell, Elizabeth, Merchant, Kumail, Capone, Christine, Gefen, Ashley M., Steinberg, Julie, and Sethna, Christine B.

Published
2021
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34. Continued reduction in peritonitis rates in pediatric dialysis centers: results of the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) Collaborative

Author

Neu, Alicia M., Richardson, Troy, De Souza, Heidi Gruhler, Mahon, Allison Redpath, Keswani, Mahima, Zaritsky, Joshua, Munshi, Raj, Swartz, Sarah, Sethna, Christine B., Somers, Michael J.G., and Warady, Bradley A.

Subjects
Chronic kidney failure -- Statistics -- Care and treatment -- Complications and side effects, Hemodialysis facilities -- Quality management, Hemodialysis -- Statistics -- Complications and side effects, Pediatric research, Peritonitis -- Statistics -- Risk factors -- Prevention, Health
Abstract

Background In its first 3 years, the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) Collaborative demonstrated a statistically significant increase in the likelihood of compliance with a standardized follow-up care bundle and a significant reduction in peritonitis. We sought to determine if compliance with care bundles and low peritonitis rates could be sustained in centers continuously participating for 84 months. Methods Centers that participated from collaborative launch through the 84-month study period and provided pre-launch peritonitis rates were included. Children on maintenance peritoneal dialysis were eligible for enrollment. Changes in bundle compliance were assessed using a logistic regression model or a generalized linear mixed model (GLMM). Changes in average annualized peritonitis rates over time were modeled using GLMMs. Results Nineteen centers contributed 1055 patients with 1268 catheters and 17,247 follow-up encounters. The likelihood of follow-up compliance increased significantly over the study period (OR 1.05 95% confidence interval (CI) 1.03, 1.07; p < 0.001). Centers achieved [greater than or equal to] 80% follow-up bundle compliance by 28 months and maintained a mean compliance of 84% between 28 and 84 months post-launch. Average monthly peritonitis rates decreased from 0.53 (95% CI 0.37, 0.70) infections per patient-year pre-launch to 0.30 (95% CI 0.23, 0.43) at 84 months post-launch, p < 0.001. Conclusions Centers participating in the SCOPE Collaborative for 84 months achieved and maintained a high level of compliance with a standardized follow-up care bundle and demonstrated a significant and continued reduction in average monthly peritonitis rates. Graphical abstract, Author(s): Alicia M. Neu [sup.1] , Troy Richardson [sup.2] , Heidi Gruhler De Souza [sup.2] , Allison Redpath Mahon [sup.3] , Mahima Keswani [sup.4] , Joshua Zaritsky [sup.5] , Raj [...]

Published
2021
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36. Hemolytic Uremic Syndrome

Author

Sethna, Christine B., Gurusinghe, Shari, Trachtman, Howard, editor, Herlitz, Leal C., editor, Lerma, Edgar V., editor, and Hogan, Jonathan J., editor

Published
2019
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37. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Author

Gharavi, Ali, Ahn, Wooin, Appel, Gerald B., Avasare, Rupali S., Babayev, Revekka, Batal, Ibrahim, Bomback, Andrew S., Brown, Eric, Campenot, Eric S., Canetta, Pietro, Chan, Brenda, D’Agati, Vivette D., Fernandez, Hilda, Foroncewicz, Bartosz, Ghiggeri, Gian Marco, Hines, William H., Jain, Namrata G., Kiryluk, Krzysztof, Lin, Fangming, Lugani, Francesca, Marasa, Maddalena, Markowitz, Glen, Mohan, Sumit, Mucha, Krzysztof, Nickolas, Thomas L., Radhakrishnan, Jai, Rao, Maya K., Regunathan-Shenk, Renu, Sanna-Cherchi, Simone, Santoriello, Dominick, Stokes, Michael B., Yu, Natalie, Valeri, Anthony M., Zviti, Ronald, Greenbaum, Larry A., Smoyer, William E., Al-Uzri, Amira, Ashoor, Isa, Aviles, Diego, Baracco, Rossana, Barcia, John, Bartosh, Sharon, Belsha, Craig, Braun, Michael C., Chishti, Aftab, Claes, Donna, Cramer, Carl, Davis, Keefe, Erkan, Elif, Feig, Daniel, Freundlich, Michael, Hanna, Melisha, Hidalgo, Guillermo, Jain, Amrish, Khalid, Myda, Kallash, Mahmoud, Lane, Jerome C., Mahan, John, Mathews, Nisha, Nester, Carla, Pan, Cynthia, Patel, Hiren, Revell, Adelaide, Sreedharan, Rajasree, Steinke, Julia, Wenderfer, Scott E., Wong, Craig S., Falk, Ronald, Cook, William, Derebail, Vimal, Fogo, Agnes, Gasim, Adil, Gehr, Todd, Harris, Raymond, Kidd, Jason, Laurin, Louis-Philippe, Pendergraft, Will, Pichette, Vincent, Powell, Thomas Brian, Renfrow, Matthew B., Royal, Virginie, Holzman, Lawrence B., Adler, Sharon, Alpers, Charles, Matar, Raed Bou, Brown, Elizabeth, Choi, Michael, Dell, Katherine M., Dukkipati, Ram, Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal, Gipson, Patrick, Hasely, Leah, Hingorani, Sangeeta, Hladunewich, Michelle A., Hogan, Jonathan, Jefferson, J. Ashley, Jhaveri, Kenar, Johnstone, Duncan B., Kaskel, Frederick, Kogan, Amy, Kopp, Jeffrey, Lemley, Kevin V., Dieguez, Laura Malaga, Meyers, Kevin, Neu, Alicia, O'Shaughnessy, Michelle Marie, O’Toole, John F., Parekh, Rulan, Reich, Heather, Reidy, Kimberly, Rondon, Helbert, Sambandam, Kamalanathan K., Sedor, John R., Selewski, David T., Sethna, Christine B., Schelling, Jeffrey, Sperati, John C., Swiatecka-Urban, Agnes, Trachtman, Howard, Tuttle, Katherine R., Weisstuch, Joseph, Zhdanova, Olga, Gillespie, Brenda, Gipson, Debbie S., Herreshoff, Emily, Kretzler, Matthias, Robinson, Bruce M., Mariani, Laura, Troost, Jonathan P., Wladkowski, Matthew, Guay-Woodford, Lisa M., Murphy, Shannon L., Mahan, John D., Srivastava, Tarak, Kogon, Amy J., Cai, Yi, Davis, T. Keefe, Gbadegesin, Rasheed A., Canetta, Pietro A., Nachman, Patrick H., Reeve, Bryce B., Wang, Chia-shi, and Bartosh, Sharon M.

Published
2020
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39. Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today

Author

Trachtman, Howard, primary, Desmond, Hailey, additional, Williams, Amanda L., additional, Mariani, Laura H., additional, Eddy, Sean, additional, Ju, Wenjun, additional, Barisoni, Laura, additional, Ascani, Heather K., additional, Uhlmann, Wendy R., additional, Spino, Cathie, additional, Holzman, Lawrence B., additional, Sedor, John R., additional, Gadegbeku, Crystal, additional, Subramanian, Lalita, additional, Lienczewski, Chrysta C., additional, Manieri, Tina, additional, Roberts, Scott J., additional, Gipson, Debbie S., additional, Kretzler, Matthias, additional, Massengill, Susan, additional, Lo, Layla, additional, Dell, Katherine, additional, O’Toole, John, additional, Sedor, John, additional, Martin, Blair, additional, Macumber, Ian, additional, Sharma, Silpa, additional, Srivastava, Tarak, additional, Markus, Kelsey, additional, Sethna, Christine, additional, Vento, Suzanne, additional, Canetta, Pietro, additional, Olabisi, Opeyemi, additional, Gbadegesin, Rasheed, additional, Smith, Maurice, additional, Greenbaum, Laurence, additional, Wang, Chia-shi, additional, Yun, Emily, additional, Adler, Sharon, additional, LaPage, Janine, additional, Amarah, Amatur, additional, Itteera, Mathew, additional, Atkinson, Meredith, additional, Williams, Miahje, additional, Lieske, John, additional, Hogan, Marie, additional, Fervenza, Fernando, additional, Selewski, David, additional, Alston, Cheryl, additional, Reidy, Kim, additional, Ross, Michael, additional, Kaskel, Frederick, additional, Flynn, Patricia, additional, Malaga-Dieguez, Laura, additional, Zhdanova, Olga, additional, Pehrson, Laura Jane, additional, Miranda, Melanie, additional, Almaani, Salem, additional, Roberts, Laci, additional, Lafayette, Richard, additional, Dave, Shiktij, additional, Lee, Iris, additional, Shah, Shweta, additional, Batla, Sadaf, additional, Reich, Heather, additional, Hladunewich, Michelle, additional, Ling, Paul, additional, Romano, Martin, additional, Brakeman, Paul, additional, Dylewski, James, additional, Rogers, Nathan, additional, McCarthy, Ellen, additional, Creed, Catherine, additional, Fornoni, Alessia, additional, Bandes, Miguel, additional, Mariani, Laura, additional, Modi, Zubin, additional, Williams, A., additional, Ni, Roxy, additional, Nachman, Patrick, additional, Rheault, Michelle, additional, Kowalski, Amy, additional, Rauwolf, Nicolas, additional, Derebail, Vimal, additional, Gibson, Keisha, additional, Froment, Anne, additional, Kelley, Sara, additional, Holzman, Lawrence, additional, Meyers, Kevin, additional, Kallem, Krishna, additional, Edwards, Aliya, additional, Sharma, Samin, additional, Roehm, Elizabeth, additional, Sambandam, Kamalanathan, additional, Brown, Elizabeth, additional, Hellewege, Jamie, additional, Jefferson, Ashley, additional, Hingorani, Sangeeta, additional, Tuttle, Katherine, additional, Manahan, Linda, additional, Pao, Emily, additional, Kuykendall, Kelli, additional, Lin, Jen Jar, additional, Dharnidharka, Vikas, additional, Gillespie, Brenda, additional, Salmon, Eloise, additional, Trachtman, Howard, additional, Mainieri, Tina, additional, Alter, Gabrielle, additional, Arbit, Michael, additional, Fermin, Damian, additional, Larkina, Maria, additional, Lienczewski, Chrysta, additional, Scherr, Rebecca, additional, Troost, Jonathan, additional, Williams, Amanda, additional, Zhai, Yan, additional, Kincaid, Colleen, additional, Li, Shengqian, additional, Li, Shannon, additional, Sampson, Matthew G., additional, Smith, Abigail, additional, Zee, Jarcy, additional, Avila-Casado, Carmen, additional, Bagnasco, Serena, additional, Bu, Lihong, additional, Caltharp, Shelley, additional, Cassol, Clarissa, additional, Demeke, Dawit, additional, Hassler, Jared, additional, Herlitz, Leal, additional, Hewitt, Stephen, additional, Hodgin, Jeff, additional, Holanda, Danni, additional, Kambham, Neeraja, additional, Lemley, Kevin, additional, Messias, Nidia, additional, Mikhailov, Alexei, additional, Moreno, Vanessa, additional, Najafian, Behzad, additional, Palmer, Matthew, additional, Rosenberg, Avi, additional, Royal, Virginie, additional, Sekulik, Miroslav, additional, Stokes, Barry, additional, Thomas, David, additional, Wu, Ming, additional, Yamashita, Michifumi, additional, Yin, Hong, additional, Zuo . Cochairs, Yiqin, additional, and Nast, Cynthia, additional

Published
2024
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41. Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome

Author

Srivastava, Tarak, primary, Garola, Robert E., additional, Zhou, Jianping, additional, Boinpelly, Varun Chandra, additional, Rezaiekhaligh, Mohammad H., additional, Joshi, Trupti, additional, Jiang, Yuexu, additional, Ebadi, Diba, additional, Sharma, Siddarth, additional, Sethna, Christine, additional, Staggs, Vincent S., additional, Sharma, Ram, additional, Gipson, Debbie S., additional, Hao, Wei, additional, Wang, Yujie, additional, Mariani, Laura H., additional, Hodgin, Jeffrey B., additional, Rottapel, Robert, additional, Yoshitaka, Teruhito, additional, Ueki, Yasuyoshi, additional, and Sharma, Mukut, additional

Published
2023
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42. Reclassification of Adolescent Ambulatory Prehypertension and Unclassified Blood Pressures by 2022 American Heart Association Pediatric Ambulatory Blood Pressure Monitoring Guidelines

Author

Hill-Horowitz, Taylor, primary, Merchant, Kumail, additional, Abdullah, Mahie, additional, Castellanos-Reyes, Laura, additional, Singer, Pamela, additional, Dukkipati, Haripriya, additional, Frank, Rachel, additional, Sethna, Christine B., additional, and Basalely, Abby, additional

Published
2023
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43. Pediatric COVID-19-associated rhabdomyolysis: a case report

Author

Gefen, Ashley M., Palumbo, Nancy, Nathan, Suresh K., Singer, Pamela S., Castellanos-Reyes, Laura J., and Sethna, Christine B.

Subjects
Rhabdomyolysis -- Case studies -- Diagnosis -- Care and treatment -- Complications and side effects, Pediatric research -- Case studies, Health
Abstract

COVID-19 is the illness caused by infection with the novel coronavirus SARS-CoV-2. Although myalgia is common in adults, it has not been noted as a common symptom in children. There have been a few reported cases of COVID-19-associated rhabdomyolysis in adults. This case report describes a 16-year-old boy who presented with fever, myalgias, mild shortness of breath with exertion, and dark-colored urine. COVID-19 PCR was positive. His initial creatinine kinase (CK) level was 427,656 U/L. Serum creatinine was normal for age. He was treated with isotonic intravenous fluids containing sodium bicarbonate to maintain urine output of 100-200 mL/h and urine pH > 7.0. His serum creatinine remained normal throughout the hospital stay and he was discharged on hospital day 12 with a CK of 6526 U/L. To our knowledge, no pediatric cases of COVID-19-associated rhabdomyolysis have been previously reported. Adult cases of rhabdomyolysis have been reported and a few reports have noted patients with elevated CK levels without rhabdomyolysis. Given this pediatric case of COVID-19-associated rhabdomyolysis, pediatric clinicians should be aware of this complication and manage fluids appropriately in order to prevent acute kidney injury., Author(s): Ashley M. Gefen [sup.1] , Nancy Palumbo [sup.2] , Suresh K. Nathan [sup.2] , Pamela S. Singer [sup.1] , Laura J. Castellanos-Reyes [sup.1] , Christine B. Sethna [sup.1] Author [...]

Published
2020
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44. Abstract P195: Association Of Unmet Social Needs With Antihypertensive Medication Prescription And Dietitian Referral: Interim Analysis Of The Study Of The Epidemiology Of Pediatric Hypertension Registry (SUPERHERO)

Author

Onugha, Elizabeth A, primary, Campbell, Jessica F, additional, Londeree, Jackson, additional, Misurac, Jason, additional, Riar, Sandeep, additional, Sethna, Christine, additional, Siddiqui, Sahar, additional, Weaver, Donald J, additional, Yamaguchi, Ikuyo, additional, Vincent, Carol, additional, and South, Andrew, additional

Published
2023
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45. Abstract P197: The Total And Direct Effects Of Cardiovascular Risk Factors On Target Organ Injury And The Indirect Effect Mediated Through Blood Pressure Severity: Modifying Effect Of Chronic Kidney Disease

Author

Vincent, Carol, primary, Campbell, Jessica F, additional, Londeree, Jackson, additional, Misurac, Jason, additional, Murphy, Maggie, additional, Onugha, Elizabeth, additional, Riar, Sandeep, additional, Sethna, Christine, additional, Siddiqui, Sahar, additional, Weaver, Donald J, additional, Yamaguchi, Ikuyo, additional, and South, Andrew, additional

Published
2023
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46. Abstract P196: Association Of Chronic Kidney Disease With Blood Pressure Severity And Target Organ Injury At Baseline In Youth Referred For Hypertension Disorders

Author

Vincent, Carol, primary, Campbell, Jessica F, additional, Londeree, Jackson, additional, Misurac, Jason, additional, Murphy, Maggie, additional, Onugha, Elizabeth, additional, Riar, Sandeep, additional, Sethna, Christine, additional, Siddiqui, Sahar, additional, Weaver, Donald J, additional, Yamaguchi, Ikuyo, additional, and South, Andrew, additional

Published
2023
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47. Abstract P198: Initial Management Of Hypertensive Disorders In Youth With And Without Chronic Kidney Disease

Author

Vincent, Carol, primary, Campbell, Jessica F, additional, Londeree, Jackson, additional, Murphy, Maggie, additional, Misurac, Jason M, additional, Onugha, Elizabeth, additional, Riar, Sandeep, additional, Sethna, Christine, additional, Siddiqui, Sahar, additional, Weaver, Donald J, additional, Yamaguchi, Ikuyo, additional, and South, Andrew, additional

Published
2023
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50. Cardiovascular disease risk among children with focal segmental glomerulosclerosis: a report from the chronic kidney disease in children study

Author

Sethna, Christine B., Ng, Derek K., Jiang, Shuai, Saland, Jeff, Warady, Bradley A., Furth, Susan, and Meyers, Kevin E.

Subjects
Glomerulonephritis -- Complications and side effects, Cardiovascular diseases -- Risk factors -- Demographic aspects, Pediatric research, Health
Abstract

Background The aims were to compare the cardiovascular disease (CVD) risk among children with chronic kidney disease (CKD) secondary to focal segmental glomerulosclerosis (FSGS) with the CVD risk of children with CKD due to other diagnoses. Methods Casual blood pressure (BP), ambulatory blood pressure monitoring (APBM), echocardiogram, lipids, carotid intima medial thickness (cIMT), and uric acid obtained from participants in the Chronic Kidney Disease in Children (CKiD) cohort were analyzed longitudinally. Seventy-nine children with FSGS (FSGS-CKD) were compared to 196 children with non-FSGS glomerular disease (GDO-CKD) and 616 children with non-glomerular disease (NG-CKD). Results At baseline, FSGS-CKD (median 14 years) had ambulatory hypertension (24.6%), masked hypertension (46.2%), left ventricular hypertrophy (LVH) (26.3%), and dyslipidemia (60.0%). In adjusted models, FSGS-CKD had higher systolic BP z-score (0.52 vs 0.11 and 0.23, p = 0.002 and 0.02), triglycerides (133 vs 109 and 102 mg/dl, p = 0.007 and < 0.001), and non-high density lipoprotein (144 vs 132 and 119 mg/dl, p = 0.07 and < 0.001) at baseline when compared to GDO-CKD and NG-CKD, respectively. Left ventricular mass index (LVMI) (36.0 vs 31.7 g/m.sup.2.7, p < 0.001) and the odds of LVH (OR 3.38, 95% CI 1.42, 8.08) at baseline were greater in FSGS-CKD compared to NG-CKD. Adjusted longitudinal analysis showed that FSGS-CKD had a faster decline in LVMI than NG-CKD, and FSGS-CKD had a faster increase in uric acid compared to both groups. Conclusions Children with CKD due to FSGS had a relatively high prevalence of CVD risk factors. FSGS was associated with greater CVD risk when compared to other CKD diagnoses., Author(s): Christine B. Sethna [sup.1] [sup.2] , Derek K. Ng [sup.3] , Shuai Jiang [sup.3] , Jeff Saland [sup.4] , Bradley A. Warady [sup.5] , Susan Furth [sup.6] , Kevin [...]

Published
2019
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