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4,472 results on '"Sesso A"'

5. District-wide herd sanitation and eradication of intramammary Staphylococcus aureus genotype B infection in dairy herds in Ticino, Switzerland

Author

L. Sesso, T. Vanzetti, J. Weber, M. Vaccani, P. Riva Scettrini, C. Sartori, I. Ivanovic, A. Romanò, M. Bodmer, L.N. Bacciarini, R. Struchen, A. Steiner, and H.U. Graber

Subjects
Staphylococcus aureus, cattle, mastitis, herd sanitation, cure, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract

ABSTRACT: The present study demonstrates successful herd sanitation and eradication of contagious mastitis caused by Staphylococcus aureus genotype B (GTB) in an entire Swiss district (Ticino) including 3,364 dairy cows from 168 farms. Herd sanitation included testing of all cows using a highly GTB-specific and sensitive real-time quantitative PCR (qPCR) assay, implementation of related on-farm measures, appropriate antibiotic therapy of GTB-positive cows, and culling of therapy-resistant animals, respectively. A treatment index was used as an objective criterion to select GTB-positive cows eligible for culling and replacement payment. Sixty-two herds (37%) were initially GTB-positive with a cow prevalence between 10% and 100% and were submitted to sanitation. Twenty months after the start of the campaign, all of these herds were free from S. aureus GTB, whereby 73% of them were sanitized during the first 7 mo. At the cow level, a total of 343 animals were infected. Fifty of them were immediately culled and farmers were financially compensated based on their treatment index value. The remaining 293 cows were intramammarily treated with antibiotics either during lactation using the combination of cephalexin-kanamycin or penicillin-gentamicin or at dry-off using cloxacillin. Out of these cows, 275 (93.9%) were treated successfully, meaning that their milk was twice GTB-negative by qPCR after therapy. For lactational treatment, control samples were taken ≥10 and ≥20 d after treatment, for dry-off treatment ≥14 and ≥24 d after parturition. Neither lactation number nor SCC before treatment of the cow nor the type of therapy was associated with therapeutic cure. Using data of 30 GTB-positive and 71 GTB-negative herds (1,855 observations), the effect of GTB sanitation on bulk tank milk SCC (BTSCC) was evaluated by applying a linear mixed statistical model. In the year before sanitation, BTSCC was always higher in GTB-positive than in GTB-negative herds. After the start of the campaign, BTSCC declined rapidly in the herds under GTB sanitation and achieved values that no longer differed statistically from those of GTB-free herds after only 2 mo, remaining very similar for the rest of the campaign. The farmers were very satisfied with the outcome of the campaign because all GTB-positive herds could be sanitized rapidly, sanitation was sustainable, and milk quality increased.

Published
2024
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6. Sex-Specific Associations between Adiponectin and Leptin Signaling and Pancreatic Cancer Survival.

Author

Babic, Ana, Wang, Qiao-Li, Lee, Alice, Yuan, Chen, Rifai, Nader, Luo, Juhua, Tabung, Fred, Wactawski-Wende, Jean, Saquib, Nazmus, Kim, Jihye, Kraft, Peter, Sesso, Howard, Buring, Julie, Giovannucci, Edward, Manson, JoAnn, Stampfer, Meir, Ng, Kimmie, Fuchs, Charles, Wolpin, Brian, and Shadyab, Aladdin

Subjects
Male, Humans, Female, Leptin, Adiponectin, Adipokines, Receptors, Adiponectin, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Receptors, Leptin
Abstract

BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated. METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific differences in adipokine levels, associations were evaluated separately for men and women. In a subset of 415 patients, we genotyped 23 SNPs in adiponectin receptor genes (ADIPOR1 and ADIPOR2) and 30 SNPs in the leptin receptor gene (LEPR). RESULTS: Adiponectin levels were inversely associated with survival in women [HR, 1.71; 95% confidence interval (CI), 1.15-2.54]; comparing top with bottom quartile but not in men (HR, 0.89; 95% CI, 0.46-1.70). The SNPs rs10753929 and rs1418445 in ADIPOR1 were associated with survival in the combined population (per minor allele HR, 0.66; 95% CI, 0.51-0.84, and HR, 1.33; 95% CI, 1.12-1.58, respectively). Among SNPs in LEPR, rs12025906, rs3790431, and rs17127601 were associated with survival in the combined population [HRs, 1.54 (95% CI, 1.25-1.90), 0.72 (95% CI, 0.59-0.88), and 0.70 (95% CI, 0.56-0.89), respectively], whereas rs11585329 was associated with survival in men only (HR, 0.39; 95% CI, 0.23-0.66; Pinteraction = 0.0002). CONCLUSIONS: High levels of adiponectin in the prediagnostic period were associated with shorter survival among women, but not among men with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR are associated with patient survival. IMPACT: Our findings reveal the association between adipokine signaling and pancreatic cancer survival and demonstrate the importance of examining obesity-associated pathways in relation to pancreatic cancer in a sex-specific manner.

Published
2023

7. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.

Author

Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham, Goodman, Phyllis, Haiman, Christopher, Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel, Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja, Brais, Lauren, Brennan, Paul, Buring, Julie, Rabe, Kari, Bamlet, William, Chanock, Stephen, Fuchs, Charles, Gaziano, J, Giovannucci, Edward, Hackert, Thilo, Hassan, Manal, Katzke, Verena, Kurtz, Robert, Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann, Orlow, Irene, Porta, Miquel, Real, Francisco, Rothman, Nathaniel, Sesso, Howard, Silverman, Debra, Thompson, Ian, Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian, Duell, Eric, Li, Donghui, Hung, Rayjean, Perdomo, Sandra, McCullough, Marjorie, Freedman, Neal, Patel, Alpa, Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen, Kraft, Peter, Risch, Harvey, Amundadottir, Laufey, Klein, Alison, Stolzenberg-Solomon, Rachael, Antwi, Samuel, King, Sontoria, Veliginti, Swathi, Brouwers, Martijn, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica, Wilkens, Lynne, Shu, Xiao-Ou, Arslan, Alan, Beane Freeman, Laura, and Bracci, Paige

Subjects
Humans, Non-alcoholic Fatty Liver Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Mendelian Randomization Analysis, Pancreatic Neoplasms, Obesity, Polymorphism, Single Nucleotide
Abstract

BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer. METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes. RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample. CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk. IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer.

Published
2023

9. Emotional Dysregulation and Sleep Problems: A Transdiagnostic Approach in Youth

Author

Gianluca Sesso, Fulvio Guccione, Simone Pisano, Elena Valente, Antonio Narzisi, Stefano Berloffa, Pamela Fantozzi, Valentina Viglione, Annarita Milone, and Gabriele Masi

Subjects
sleep, emotional dysregulation, adolescents, youth, Medicine (General), R5-920
Abstract

Background: Sleep is a complex phenomenon that affects several aspects of life, including cognitive functioning, emotional regulation, and overall well-being. Sleep disturbances, especially during adolescence, can negatively impact emotional regulation, making it a critical factor in targeting psychopathology. Methods: This study explores the interplay between emotional dysregulation (ED) and sleep patterns in a sample of 90 adolescent patients by means of self- and parent-rated clinical measures. Results: Our findings reveal a bidirectional relationship between ED and sleep problems. Adolescents with higher affective instability experience poorer sleep quality, while those with worse sleep quality exhibit higher internalizing problems. Additionally, emotional reactivity is associated with disrupted circadian rhythms. Conclusions: These results emphasize the significance of addressing sleep problems in the context of psychopathology treatment, potentially leading to improved outcomes. Further research is needed to determine the most effective treatment strategies, including nonpharmacological and pharmacological interventions. Understanding the intricate relationship between sleep problems and emotion regulation offers insights for more targeted and effective treatment approaches for youths struggling with ED.

Published
2024
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10. Laboratory-based surveillance of chronic kidney disease in people with private health coverage in Brazil

Author

Farid Samaan, Rubens Carvalho Silveira, Amilton Mouro, Gianna Mastroianni Kirsztajn, and Ricardo Sesso

Subjects
Epidemiology, Prevalence, Information systems in clinical laboratory, Chronic kidney disease, Supplementary health, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Although approximately 25% of Brazilians have private health coverage (PHC), studies on the surveillance of chronic kidney disease (CKD) in this population are scarce. The objective of this study was to estimate the prevalence of CKD in individuals under two PHC regimes in Brazil, who total 8,335,724 beneficiaries. Methods Outpatient serum creatinine and proteinuria results of individuals from all five regions of Brazil, ≥ 18 years of age, and performed between 10/01/2021 and 10/31/2022, were analyzed through the own laboratory network database. People with serum creatinine measurements were evaluated for the prevalence and staging of CKD, and those with simultaneous measurements of serum creatinine and proteinuria were evaluated for the risk category of the disease. CKD was classified according to current guidelines and was defined as a glomerular filtration rate (GFR)

Published
2024
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11. The FinO/ProQ-like protein PA2582 impacts antimicrobial resistance in Pseudomonas aeruginosa

Author

Anastasia Cianciulli Sesso, Armin Resch, Isabella Moll, Udo Bläsi, and Elisabeth Sonnleitner

Subjects
RNA-binding protein, ProQ, Pseudomonas aeruginosa, antibiotic resistance, aminoglycosides, antimicrobial peptides, Microbiology, QR1-502
Abstract

Bacteria employ small regulatory RNAs (sRNA) and/or RNA binding proteins (RBPs) to respond to environmental cues. In Enterobacteriaceae, the FinO-domain containing RBP ProQ associates with numerous sRNAs and mRNAs, impacts sRNA-mediated riboregulation or mRNA stability by binding to 5′- or 3′-untranslated regions as well as to internal stem loop structures. Global RNA-protein interaction studies and sequence comparisons identified a ProQ-like homolog (PA2582/ProQPae) in Pseudomonas aeruginosa (Pae). To address the function of ProQPae, at first a comparative transcriptome analysis of the Pae strains PAO1 and PAO1ΔproQ was performed. This study revealed more than 100 differentially abundant transcripts, affecting a variety of cellular functions. Among these transcripts were pprA and pprB, encoding the PprA/PprB two component system, psrA, encoding a transcriptional activator of pprB, and oprI, encoding the outer membrane protein OprI. RNA co-purification experiments with Strep-tagged Pae ProQ protein corroborated an association of ProQPae with these transcripts. In accordance with the up-regulation of the psrA, pprA, and pprB genes in strain PAO1ΔproQ a phenotypic analysis revealed an increased susceptibility toward the aminoglycosides tobramycin and gentamicin in biofilms. Conversely, the observed down-regulation of the oprI gene in PAO1ΔproQ could be reconciled with a decreased susceptibility toward the synthetic cationic antimicrobial peptide GW-Q6. Taken together, these studies revealed that ProQPae is an RBP that impacts antimicrobial resistance in Pae.

Published
2024
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12. Produto Interno Bruto e pegada hídrica do agronegócio: comparativo entre países

Author

Umberto Antonio Sesso Filho, Ricardo Luís Lopes, Carlos Alberto Gonçalves Junior, Emerson Guzzi Zuan Esteves, and Patrícia Pompermayer Sesso

Subjects
água, pegada hídrica, agronegócio, sustentabilidade, insumo-produto, Agriculture (General), S1-972
Abstract

Resumo O objetivo do presente estudo é dimensionar o agronegócio dos países em termos de renda (Produto Interno Bruto - PIB) e água (pegada hídrica), além de estimar um indicador de sustentabilidade (água por unidade de renda). A metodologia é baseada na matriz insumo-produto e foi aplicada para 189 países com enfoque sobre as vinte maiores economias (PIB) no ano de 2015. O PIB do agronegócio mundial era de US$12,3 trilhões e a pegada hídrica de 151 trilhões de metros cúbicos, os valores representavam respectivamente 18% e 97,5% dos totais do sistema produtivo. A participação da renda do agronegócio no total do sistema produtivo dos países variou entre 4% e 61%. Os maiores valores do PIB do agronegócio foram obtidos para a China (US$ 2,5 trilhões), Estados Unidos (US$ 1,4 trilhão), Índia (US$ 0,67 trilhão), Japão (US$ 0,5 trilhão) e Brasil (US$ 0,43 trilhão). O custo ambiental do agronegócio mensurado em metros cúbicos de água para mil dólares de geração de renda (m3/US$) variou entre menos de cem metros cúbicos para cada mil dólares de renda gerada para mais de 200 mil, o que indica que existe a possibilidade do aumento da eficiência do uso da água e sustentabilidade por meio do desenvolvimento de novas tecnologias.

Published
2024
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15. Efficacy and Safety of Lithium for Suicide and Suicide-Related Behaviors in Youth: A Review of the Literature

Author

Gianluca Sesso, Francesca Bargnesi, Francesca Olzi, Giulia Mutti, Stefano Berloffa, Valentina Viglione, Pamela Fantozzi, Greta Tolomei, Fulvio Guccione, Annarita Milone, and Gabriele Masi

Subjects
lithium, youth, adolescents, suicide, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Objectives: This systematic review evaluates the anti-suicidal properties of Lithium in children and adolescents with Bipolar Disorder (BD), addressing gaps in evidence regarding its efficacy and safety in reducing suicidality and self-harming behaviors. Methods: A comprehensive literature search was conducted across PubMed, Web of Science, and Scopus up to February 2024. Eligible studies were those focusing on patients aged 25 years or younger, examining Lithium therapy and its impact on suicidal ideation and behaviors. The review included randomized controlled trials, longitudinal prospective and retrospective studies, and cross-sectional studies, while excluding expert opinions and case reports. Results: Evidence generally supports the efficacy of Lithium in reducing suicidal ideation and self-harming behaviors in youth with BD, though results are mixed. Randomized controlled trials demonstrated its effectiveness in mitigating suicidal thoughts during acute manic episodes, with effects persisting post-treatment. Longitudinal studies suggested that Lithium might offer superior outcomes compared to other mood stabilizers, although its specific impact on suicidality remains inconclusive. Cross-sectional studies and retrospective analyses reveal associations between Lithium use and reduced self-harming behaviors, but causality remains uncertain. While mood-stabilizing effects of Lithium offer potential benefits for reducing suicidality in youth, evidence on its direct impact on emotional dysregulation (ED) and long-term efficacy is limited. Variability in individual responses and adherence issues underscore the need for further research. Future studies should include larger, diverse samples, focus on ED symptoms, and explore Lithium mechanisms in suicidality prevention. Conclusions: Lithium remains a promising treatment for mood stabilization and reduction in suicidality in youth with BD.

Published
2024
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16. Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study

Author

Abraham, Rachael, Ager, Arijan, Aguilar, Franchesca A., Ahmadi-Izad, Ghazal, Ahmed, Dilshad R., Alvarez, Alicarmen, Anderson, Blake, Asencios, Walter D., Atha, Mary, Beaty, Casey L., Bedi, Brahmchetna, Berry, Jasmine A., Boone, Donchel, Bower, Mary, Bremner, James D., Brent, Corbin, Brown-Smith, Ke'Ara, Bull, Rachel, Bush, Patricia A., Capo, Gustavo, Carl-Igwe, Kelechi, Chitadze, Calista, Chukwumerije, Nachi, Clyburn, Erna, Collins, Shelby, Costello, Julie, Couture, Grace, Craft, Angel, Cribbs, Sushma K., Cui, Xiangqin, Dandy, Annette, Rio, Carlos del, Jasarevic, Rijalda, Detelich, Joshua F., Dixon, Cartia, Dow, Jeanne, Doyle, D'Andrea, Elchommali, Jannah, Ibeawuchi, Carmel, Elsey, Imani, Fineman, Rebecca, Francis, Anyssa G., Franks, Nicole, Gallini, Julia, Gander, Jennifer C., Gray, Natalie, Grimes, Ash, Gutter, Evan, Han, Jenny E., Hang, Tina P., Harding, Jess, Hernandez, Liliana, Hewitt, Lauren N., Holloway, Carla, Hudgins, Alex F., Huerta, Christopher, Ifejika, Cynthia, Ingram, Ketteria D., Javia, Vidhi N., Jeter, Mykayla, Johnson, Brandi, Joseph, Yasha, Juarez, Monica, Kajan, Dana, Khalil, Lana, Kirkpatrick, Caitlin M., Kleinhenz, Dean, Kolailat, Imanii, Koumanelis, Athena, Koumanelis, Alexandra, Kozoman, Rebecca, Krishnan, Shilpa, Lainez, Jordi, Lawrence, Brianna, Lee, Matthew A., Leon, Jose D., Lew, Valerie, Lewis, Kennedy C., Litvack, Matthew, Maroney, Mara, Maier, Cheryl L., Makkaoui, Nour, Marconi, Vincent C., Martin, Christopher F., Martinez, Monica, Mbogo, Loice, McCaslin, Atuarra, McIntyre, Jerrod, Moanna, Abeer, Montoya, Miranda, Morales, Elena, Moran, Caitlin A., Morgan-Billingslea, Jan, Murray, Calista, Nelson, Roslin, Neuman, Robert B., Nguyen, Tran, Ofotokun, Ighovwerha, Ojemakinde, Elizabeth I., Ojoawo, Bukkie, Osinski, Eileen, Oviedo, Sofia, Panganiban, Bernadine, Paredes-Gaitan, Yolanda, Patzer, Rachel E., Pemu, Priscilla, Prude, Michael, Rahman, Kazi, Ramakrishnan, Grace, Rebolledo, Paulina A., Roberts, Marjorie, Robinson, Keysha, Rogers, Chantrice, Rouphael, Nadine G., Searles, Charles, Shah, Anand, Segall, Marni, Shaw, Renata M., Silva, Ruvina, Simpson, Cheryl, Simpson-Derrell, Krystal, Sirajud-Deen, Talib, Smith, Veronica E., Stringer, Andre, Stroud, Jacob, Suthar, Mehul S., Sylber, Cory, Sylvera, Ashley, Tanner, Tehquin, Teunis, Larissa J., Tolbert, Maliya, Thomas, Kodasha M., Thompson, Sierra G., Titanji, Kehmia, Toy, Christopher, Traenkner, Jessica, Truong, Alex, Unterberger, Kristen, Vaccarino, Viola, Varney, Kris, Vyas, Kartavya, Vyas, Kurt, Walker, Tiffany A., Walkow, Max, Wang, Dongli, Wesley, Tamara, Wiley, Zanthia, Wimberly, Erika, Winston, Juton R., Winter, Terra J., Wongtrakool, Cherry, Aikawa, Masanori, Alba, George A., Aung, Taing N., Baden, Lindsey, Baslet, Gaston, Bassett, Ingrid V., Bennett, Lindsey, Bhattacharyya, Shamik, Blazey-Martin, Deborah, Buring, Julie, Cagnina, Rebecca E., Chen, Li Qing, Clark, Cheryl R., Cohen, Pieter, Collier, Ai-Ris, Czeisler, Charles, Duffy, Elizabeth, Estill, Peter, Fong, Tamara, Gay, Elizabeth, Ghamloush, Maher, Ginns, Leo C., Haack, Monika, Haas, Jennifer, Hamburg, Naomi, Hauser, Kristine S., John, Janice, Jordan, Michael, Juelg, Boris D., Kanjilal, Diane G., Kim, Arthur Y., Klerman, Elizabeth B., Kobayashi, Misaki ., Kogelman, Laura, Lamas, Daniela, Levy, Bruce D., Levy-Carrick, Nomi, Lewis, Gregory, Maley, Jason H., Manson, JoAnn, Marathe, Jai G., Mullington, Janet M., O'Connor, George T., Ojikutu, Bisola, Perlis, Roy, Quintana, Yuri, Redline, Susan, Remis, Elijah J., Rosand, Jonathan, Sesso, Howard D., Shaughnessy, Lynn, Shepherd, Fitzgerald M., Solomon, Scott, Sparks, Jeffrey A., Spencer, Lia L., Stephenson, Kathryn, Systrom, David, Thomas, Robert J., Min Thu, Phyo Phyo, Ticotsky, Amberly, Torres, Robert, Wallace, Zachary S., Walt, David, Ward, Honorine D., Washko, George, Whittelsey, Maureen, Wiener, Rebecca, Williams, Charles T., Xerras, Dean, Zhang, Haihua, Zionts, Danielle, Armstrong, Donna, Binkley, Susan E., Blackwell, Kenneth, Brown, Todd, Carton, Thomas W., Causey, Annalia, Cook, Felice, Daniel, Casey L., Datri, Paula, Domingo, Julio, Donahue, Conner, Eady, Maitlyn, Edberg, Jeffrey, Erdmann, Nathaniel, Fuloria, Jyotsna, Garcia-McClaney, Noah, Garner, Melissa, Gillespie, Mark, Gray, Brandon, Hagensee, Michael, Hall, Wanda, Hansel, Jamie, Hart, Cady, Hebson, Camden L., Hidalgo, Bertha, Holtzapfel, Kaylen, Jinright, Alexis, Judd, Suzanne E., Kennedy, Teri, Kirkwood, Leigh, Leggio, Cathryn, Levitan, Emily B., Maier, Megan, McCormack, Patricia, Miele, Lucio, Mitchell, Kevin, Montgomery, Aoyjai, Peralta-Carcelen, Myriam, Perkins, Allen, Pilco, Juan P., Powell, Leigh, Shevin, Rachael, Skipworth, Sidney, Spurgeon, Leah, Sutherland, Erica, Tita, Alan T., Trauth, Amber, Trotter, Siobhan, Van Deerlin, Alexander, Ware, Gregory, Weiser, Sharon, Wilson, Rosanne, Woodruff, Dana, Wu, Jing, Young, Madeline, Alemu, Mhret, Anderson, Jordan, Ashktorab, Hassan, Brim, Hassan, Chang, Linda, Chauhan, Mahak, Cho, Sung, Durrani, Saima, Gentil, Monique P., Goodman, Karli, Laiyemo, Adeyinka O., Lanke, Gandi, Lebron, Ralph, Maheshwari, Anurag, Mehari, Alem, Nezamloo, Ali, Ngwa, Julius, Njoku, Noelle, Ok, Jina, Sherif, Zaki A., Solemani, Akbar, Thuluvath, Paul, To, Chau, Spikes, Leslie A., James, Judith A., Luciano Roman, Carlos A., Chow, Dominic C., Marshall, Gailen D., Dickinson, John D., Hoover, Susan E., Warren, David E., Emery, Ivette F., Sukhera, Fatima I., Rosen, Clifford J., Greenway, Frank L., Hodder, Sally L., Shikuma, Cecilia M., VanWagoner, Timothy M., Bardes, James M., Kirwan, John P., Wood, Jeremy P., Whiteheart, Sidney W., Shellito, Judd, Roelke, Theresa, Black, Lora, Tjarks, Brian, Fonseca, Vivian, Gupta, Shaveeta, Longo, Michele, Yang, Mei, MarGangcuangco, Louis, Bengtson, Charles, Castro, Mario, Howard, Theresa, Garvy, Beth, Simmons, Christopher, Garla, Vishnu, Kuebler, Joy, Nandi, Utsav, Vasey, Andrew, Bogie, Amanda, Scott, James, Frontera, Sigrid Perez, Bagur, Jorge Santana, Dominique-Villanueva, Daphne, Juskowich, Joy, Reece, Rebecca, Sarwari, Arif, Aponte-Soto, Lisa, Adams, Dara, Baker, Aileen, Barbera, Sunni, Basu, Sanjib, Bleasdale, Susan, Bolliger, Dawn, Boyd, Andrew D., Boyineni, Jerusha, Breiter, Taylor, Brown, Daniel, Buhimschi, Irina A., Carrithers, Michael D., Certa, Marta, Chalamalla, Rashmika, Chebrolu, Praneeth, Chestek, David, Chessier, Erica, Cook, Judith A., Cranford, Savannah, Curry, Hannah L., Darbar, Dawood, Dasgupta, Raktima, Blakley, Felicia Davis, DeLisa, Julie A., Del Rios, Marina, Diaz, Maya Z., Diviak, Kathleen R., Dixon, Jennifer, Donlon, Meghan F., Donohue, Sarah E., Dworkin, Mark S., Edmonds, Sherrie, Ellison, Angela, Everett, Emily, Flanigan, Clarie, Freedman, Michael B., Gale, Lisa, Gerald, Lynn B., Giles, Wayne H., Gordon, Howard S., Hafner, John, Hammad, Bayan, Hanson, Keith A., Harris, Pastor C., Hartwig, Kimberly, Hasek, Sharon, Hasse, Wendy, Hendrickson, Monica, Hobbs, Brianna, Hryniewicka, Martyna, Hammerl, Savannah, Hutton, Robert, Ibanez, Alejandra L., Illendula, Sai D., Ismail, Nahed, Jain, Akash, Jennette, Kyle J., Kadubek, Grace, Kent, Denise, Kotini-Shah, Pavitra, Kelly, Sara W., Kent, Denise A., Kim, Keri S., Kindred, Elijah, Klein, Jonathan D., Krishnan, Jerry A., Large, Lucia, Lash, James ., Lin, Janet Y., Lu, Jun, Mahamed, Abeer M., Maholovich, Phoebe, Malchenko, Sergey, Martinez, Miriam, Mauntel-Medici, Cammeo, Madineni, Abhigna, McCauley, Mark, Menchaca, Martha, Mermelstein, Robin, Moreno, David J., Morrissy, Liam, Muramatsu, Naoko, Musick, Hugh, Noland, Seth, Norwick, Lourdes, Novak, Richard M., Olds, Lela, Ortiz, Marilyn, Patel, Khushboo, Perez, Nicolas L., Pliskin, Neil H., Pope, Sam, Prabhakar, Bellur S., Prasad, Bharati, Predki, Barbara, Prendergast, Heather M., Quigley, John G., Ramchandran, Ramaswamy, Ramirez, Ana, Rappe, Sarah, Rehman, Jalees, Rolon, Cesar, Rowley, Matthew, Rudraraju, Gowrisree, Rutherfoord, Melissa, Sader, Samer B., Sculley, Jennifer A., Smith-Mack, Jerisha, Swearingen, Peyton, Stewart de Ramirez, Sarah A., Sudhindra, Praveen, Sun, Jun, Tartt, Nancy, Terlinde, Tracy, Thompson, Tiffany, Vanden Hoek, Terry L., Kelly, Sara Warfield, Villanueva, Laura, Welter, Hannah, Woolley, Brittany, Yazici, Cemal, Charney, Alexander W., Kovatch, Patricia, Merad, Miriam, Nadkarni, Girish N., Wisnivesky, Juan P., Aberg, Judith A., Ascolillo, Steven, Assenso, Esther, Bagiella, Emilia, Bartram, Logan, Becker, Jacqueline, Beckmann, Noam D., Bendl, Ashley, Chen, Benjamin K., Civil, Alyssa, Dhar, Kaberi, Evo-Ortega, Lorraine, Fierer, Daniel, Gallagher, Emily J., Garcia-Sastre, Adolfo, Gnjatic, Sacha, Guliyeva, Sabina, Harvey-Ingram, Lori, Herrera-Moreno, Julia, Hill, Matthew, Horowitz, Carol R., Jackson, Rachel, Kastrat, Din, Lala-Trindade, Anu, Lin, Jenny, Macaluso, Nick, Marcon, Kathryn, Meyer, Dara, Morinigo, Janice, Natelson, Benjamin H., Nussenzweig, Maya, Padua, Tiffani, Putrino, David, Quazi, Nawreen, Ramos, Michelle, Richardson, Lynne, Russo, Scott, Seifert, Alan C., Serri, Abdullah, Walker, Jordan, Yee, Michell, Adolphi, Natalie L., Alekhina, Natalya, Archuleta, David A., Barlocker, Jackson, Bateman, Lucinda, Bradfute, Steven B., Brito, Rebecca, Bryan, Tanner W., Buck, Kaitlin E., Davis, Debra, Deakyne Davies, Sara J., Decker, Lauren A., Elifritz, Jamie, Erlandson, Kristine M., Facelli, Julio C., Fudge, Harrison Z., Tran, Huong, Pitch, Chloe, Feuerriegel, Elen M., Ford, Isaac, Friedman, Naomi P., Garcia-Soberanez, Noella D., Gardner, Edward M., Stringham, Caitlyn, Ling, Leah, Gebremariam, Tewodros H., Gentry, Frederick D., Gouripeddi, Ramkiran, Graham, Paige, Gronert, Eve G., Harkins, Michelle S., Hawkins, Kellie L., Hess, Rachel, Johnny, Jace D., Johnson, Brandon M., Jolley, Sarah E., Lloyd, Jennifer, Ludwig, Katelyn R., Martinez, Noah I., McCandless, Sean A., Montoya, Lorenzo A., Oakes, Judy L., Parada, Alisha N., Quinn, Davin K., Raissy, Hengameh, Ramos, Alfredo, Reid, Kayleigh M., Reusch, Jane E., Sheehan, Elyce B., Sokol, Ron J., Treacher, Irena S., Trinity, Joel D., Truong, Dongngan T., West, Shelby C., Molden, Joie, Sharareh, Nasser, Weaver, Lisa J., Spivak, Adam M., Brown, Jeanette P., Shah, Kevin S., Pace, Laura A., Scholand, Mary Beth, Velinder, Matt, Cortez, Melissa, Morimoto, Sarah Shizuko, Vernon, Suzanne D., Lu, Yue, Owen, Megan, Hermansen, Jessica A., Lindsay, Ashton M., Donohue, Dagny K., Garg, Lohit, Wodushek, Thomas, Higgins, Janine, Lockie, Tim, Brightman, Marisa, Thurman, Brook, Powell, Jenny M., Freston, Dylan C., Medina, Juliemar C., Aguirre, Bailee, Anderson, Jeff, Bair, Tami, Bosh, Lindsay, Evans, Lorlie, Garrett, Chase, Harris, Dixie, Herrera, Katherine, Horne, Benjamin D., Juan, James, Knight, Stacey, Knowlton, Kirk, Leither, Lindsay, Maestas, Heather, May, Heidi T., Najarian, Gabriel, Woller, Scott C., Zubal, Shyanne, Jensen, McKenna M., Webb, Tiaura, Iverson, Leslie, Ayache, Mirna, Baloi, Alexis, Barnboym, Emma, Boldt, Nicholas, Bukulmez, Hulya, Chesnick, Hailey, Conrad, Ann, Consolo, Mary, Curtis, Lynette, D’anza, Brian, DiFrancesco, Kathryn, Edminston, Marissa, Eteshola, Ebenezer, Gallagher, Michelle, Gibson, Kelly S., Gordesky, Larraine, Greenwood, Carla, Haghiac, Maricela, Harris, Paul, Hernandez, Carla, Iqbal, Shirin, Kaelber, David C., Kaufman, Elizabeth S., Kennedy, Olivia, Labbato, Danielle, Lengu, Ketrin, Levert, Antonio, Levin, Jennifer, Lowenthal, Rebecca, Mackin, Bridget, Malakooti, Shahdi K., McComsey, Grace A., Minium, Judy, Mouchati, Christian, Oleson, Christine, Pearman, Ann, Hershey, Morgan, Rivera, Amanda, Rodgers, Michael, Rodgers, Theresa, Roy, Arnab, Russ, Kris, Scott, Sarah, Sheth, Niyati, Singer, Nora G., Smith, Beth, Smith, Cheryl, Stancin, Terry, Temple, Daniel, Tribout, Megan, Weinberger, Elisheva, Zhang, David, Zisis, Sokratis N., Atieh, Ornina, Yendewa, George, Baissary, Jhony, Pettinato, KImberly, Lim, Joaquin, Jacob, Joshua, Adams, Cara, Tejani, Viral, Algren, Heather A., Alicic, Radica, Baxter, Joni, Brennan, Conor, Caudill, Antonina, Chen, Peter, Chopra, Tananshi, Chu, Helen Y., Del Alcazar, James, Duven, Alexandria M., Edmark, Rick, Emerson, Sarah, Goldman, Jason D., Gutierrez, Vanessa, Hadlock, Jennifer, Harteloo, Alex, Heath, James R., Hood, Susan, Jackman, Susan, Kaneko, John, Kemp, Megan, Kim, Christina, Kuykendall, Kelli, Li, Sarah, Logue, Jennifer K., Magis, Andrew T., Manner, Paula, Mason, Carly, McCaffrey, Kathryn, McDonald, Connor, McDonald, Dylan, Murray, Kim M., Nackviseth, Callista, Nguyen, Helen, Parimon, Tanyalak, Poussier, Rachel, Rowen, Lee, Satira, Richard, Torbati, Sam, Tuttle, Katherine R., Wallick, Julie A., Yuan, Dan, Watanabe, Kino, Wilcox, Lauren E., Contreras, Fatima, Dahlke, Lea, Gudipudi, Lasya, Modes, Matthew, Muttera, Nicole, Salinas, Nancy, Tadeo, Josie, White, Shane, Alvarado, Stephanie, Anderson, Reed, Arellanes, Azaneth, Barajas, Rose A., Chauhan, Suneet P., Clarke, Geoffrey D., Farner, Cheryl E., Fischer, Melinda S., Goldberg, Mark P., Hasbani, Keren, Hastings, Gabrielyd, Heard, Patricia, Herrera, Italia, Infante, Edgar, Johnson, Hillary, Jones, Johnnie, Kellogg, Dean L., Kraig, Ellen, Longoria, Lisa, Nambiar, Anoop M., Okafor, Emeka, Paredes, Claudia C., Patterson, Thomas F., Patterson, Jan E., Pinones, Alexis, Potter, Jennifer S., Reeves, W.B., Saade, George R., Salehi, Marzieh, Scholler, Irma, Seshadri, Sudha, Shah, Dimpy P., Shah, Pankil, Sharma, Kumar, Sharma, Kavita, Soileau, Bridgette, Solis, Pamela, Stoebner, Carmen, Sullivan, Michael, Taylor, Barbara S., Tragus, Robin, Tsevat, Joel, Verduzco-Gutierrez, Monica, Ahuja, Neera, Blish, Catherine A., Blomkalns, Andra L., Bonilla, Hector, Brotherton, Richard, Clinton, Kimberly, Dingankar, Vaidehi, Geng, Linda N., Go, Minjoung, Haddad, Francois, Jagannathan, Prasanna, Jamero, Christopher, Jee, Kathryn, Jia, Xiaolin K., Khurana, Naresh, Kumar, Andre, Maldonado, Yvonne, Miglis, Mitchell G., O'Conor, Ellen, Olszewski, Kelly, Pathak, Divya, Quintero, Orlando, Scott, Jake, Singh, Upinder, Urdaneta, Alfredo E., Utz, Paul J., Varkey, Mary R., Saperia, Corey, Autry, Lynn, Bime, Christian, Borwege, Sabine, Copeland, Jacquelynn, DiLise-Russo, Marjorie, Ernst, Kacey C., Esquivel, Denise R., Fadden, Susan, Gomez, Isaias, Grischo, Garrett, Hansen, Lillian, Harris, David T., Harris, Stefanie, Hartley, William, Hernandez, Michael, Hillier, Leah, Hsu, Harvey, Hughes, Trina, Ismail, Hira, Iusim, Stephanie, James, Michelle, Kala, Mrinalini, Karnafel, Maria, Kim, Daniel, Knox, Kenneth S., Koleski, Alison, LaFleur, Bonnie, Lambert, Brenda, LaRue, Sicily, Lee-Iannotti, Joyce K., Lieberman, David, Lutrick, Karen, Merchant, Nirav, Morton, Christopher, Mosier, Jarrod M., Murthy, Ganesh, Nikolich, Janko Z., Olorunnisola, Toluwanimi, Parthasarathy, Sairam, Peralta, Jeanette, Pilling, William, Pogreba-Brown, Kristen, Reiman, Eric M., Rischard, Franz P., Ryan, Lee T., Smith, Terry, Snyder, Manuel, Soto, Francisco, Subbian, Vignesh, Suhr, Kyle, Unzek, Samuel, Vadovicky, Sheila, Velarde, Deanna, Veres, Sharry, Wilson, Cathleen, Anderson, Grace, Anglin, Khamal, Argueta, Urania, Asare, Kofi, Buitrago, Melissa, Chang Song, Celina, Clark, Alexus, Conway, Emily, Deeks, Steven G., Del Castillo, Nicole, Deswal, Monika, Durstenfeld, Matthew S., Eilkhani, Elnaz, Eun, Avery, Fehrman, Emily, Figueroa, Tony, Flores, Diana, Grebe, Halle, Henrich, Timothy J., Hoh, Rebecca, Hsue, Priscilla, Huang, Beatrice, Ibrahim, Rania, Kelly, John D., Kerbleski, Marian, Kirtikar, Raushun, Lew, Megan T., Lombardo, James, Lopez, Monica, Luna, Michael, Marquez, Carina, Martin, Jeffrey N., Munter, Sadie, Ngo, Lynn, Peluso, Michael J., Pineda-Ramirez, Jesus, Rhoads, Kim, Rodriguez, Antonio, Romero, Justin, Ryder, Dylan, So, Matthew, Somsouk, Ma, Tai, Viva, Tran, Brandon, Uy, Julian, Valdivieso, Daisy, Verma, Deepshika, Williams, Meghann, Zamora, Andhy, Newman, Lisa T., Abella, Julie, Barnette, Quinn, Bevc, Christine, Beverly, Jennifer, Ceger, Patricia, Croxford, Julie, Enger, Mike, Fain, Katie, Farris, Tonya, Hanlon, Sean, Hines, David, Johnson-Lawrence, Vicki, Jordan, Kevin, Lefebvre, Craig, Linas, Beth, Luukinen, Bryan, Mandal, Meisha, McKoy, Nikki J., Nance, Susan, Pasquarelli, Demian, Quiner, Claire, Sembajwe, Rita, Shaw, Gwendolyn, Thornburg, Vanessa, Tosco, Kendall, Wright, Hannah, Gross, Rachel S., Hochman, Judith S., Horwitz, Leora I., Katz, Stuart D., Troxel, Andrea B., Adler, Lenard, Akinbo, Precious, Almenana, Ramona, Aschalew, Malate, Balick, Lara, Bello, Ola, Bhuiyan, Sultana, Blachman, Nina, Branski, Ryan, Briscoe, Jasmine, Brosnahan, Shari, Bueler, Elliott, Burgos, Yvette, Caplin, Nina, Chaplin, Domonique, Chen, Yu, Cheng, Shen, Choe, Peter, Choi, Jess, Chung, Alicia, Church, Richard, Cobos, Stanley, Croft, Nakia, Irving, Angelique Cruz, Del Boccio, Phoebe, Díaz, Iván, Divers, Jasmin, Doshi, Vishal, Dreyer, Benard, Ebel, Samantha, Esquenazi-Karonika, Shari, Faustin, Arline, Febres, Elias, Fine, Jeffrey, Fink, Sandra, Freeland, Catherine, Frontera, Jennifer, Gallagher, Richard, Gonzalez-Duarte, Alejandra, Gross, Rachel, Hasson, Denise, Hill, Sophia, Hochman, Judith, Horwitz, Leora, Hossain, Jennifer, Islam, Shahidul, Jean, Christina Saint, Johnson, Stephen, Kansal, Neha, Katz, Stuart, Kenney, Rachel, Kershner, Tammy, Kewlani, Deepshikha, Kwak, Judy, Lamendola-Essel, Michelle F., Laury, Sarah, Laynor, Gregory, Lei, Lei, Leon, Terry, Linton, Janelle, Logan, Max, Malik, Nadia, Mamistvalova, Lia, Mandel, Hannah, Maranga, Gabrielle, Mattoo, Aprajita, Mei, Tony, Mendelsohn, Alan, Mercier, Emmanuelle, Vernetti, Patricio Millar, Miller, Marc, Mitchell, Maika, Moreira, Andre, Mudumbi, Praveen C., Nahin, Erica, Nair, Nandini, Nekulak, Joseph, Owens, Kellie, Parent, Brendan, Patibandla, Nandan, Petrov, Peter, Postelnicu, Radu, Pratt, Francesca, Randall, Isabelle, Rao, Priyatha, Rapkiewicz, Amy, Rizzo, JohnRoss, Rosas, Johana, Rose, Chelsea, Saint-Jean, Christina, Santacatterina, Michelle, Shah, Binita, Shaukat, Aasma, Simon, Naomi, Simsir, Aylin, Stinson, Miranda, Tang, Wenfei, Tatapudi, Vasishta, Thawani, Sujata, Thomas, Mary, Thorpe, Lorna, Tom, MeeLee, Treiha, Ethan, Troxel, Andrea, Truong, Jennifer, Udosen, Mmekom, Valencia, Carlos, Velazquez-Perez, Jessica, Vernetti, Patricio M., Vidal, Crystal, Viswanathan, Anand, Willerford, Amy, Williams, Natasha, Wong, Crystal, Wood, Marion J., Wuller, Shannon, Yin, Shonna H., Young, Chloe, Zaretsky, Jonah, Zavlunova, Susanna, Ahirwar, Shreya, Ahmed, Shifa, Ainsworth, Layne L., Atchley-Challenner, Rachel, Avilach, Paul, Balan, Trisha T., Benik, Nicholas, Benoit, Barbara, Bind, Marie-Abèle C., Bonaventura, William J., Boutin, Natalie, Brion, Beverly, Cagan, Andrew, Cai, Tianrun, Cao, Tingyi, Castro, Victor M., Cerretani, Xander R., Chan, James G., Cheng, David, Chibnik, Lori B., Ciriello, Mark, Costenbader, Karen, Dimitrov, Dimitar S., Estiri, Hossein, Fayad, Maria, Feldman, Candace H., Foulkes, Andrea, Gainer, Vivian, Ghosh, Bhaswati, Gollub, Randy, Guan, Zoe, Harris, Alan, Helmer, Karl, Hendrix, Andrew, Holzbach, Ana, Huang, Weixing, Karlson, Elizabeth W., Kaufman, Daniel, Keogh, Diane, Kerr, James D., Klann, Jeffrey G., Krishnamoorthy, Aparna, Lasky-Su, Jessica A., Liao, Katherine P., MacFadden, Doug, Maram, Anupama, Martel, Megan W., Mendis, Michael, Metta, Reeta, Monteiro, Jonathan, Morales, Eduardo, Morse, Richard E., Murphy, Shawn, Nazaire, Marc-Danie, Neils, Gregory, Nguyen, Amber N., Norman, James, Paik, Henry H., Pant, Deepti, Park, HeeKyong, Rabideau, Dustin J., Reeder, Harrison T., Rossi-Roh, Kathleen, Santacroce, Leah M., Schlepphorst, Katherine, Schulte, Carolin, Selvaggi, Caitlin A., Shinnick, Daniel J., Simons, William, Simpson, Lynn A., St. Jean Flanders, Mary L., Strasser, Zachary, Thakrar, Mansi R., Thaweethai, Tanayott, Thorn, Madeleine, Trewett, Philip, Van Fleet, Dustin, Wagholikar, Kavishwar B., Wang, Taowei D., Wattanasin, Nich, Weber, Griffin, Williams, Michael A., Zhang, Ren Zhe, Cicek, Mine, Chang, Nancy, Wirkus, Samantha, Zahnle, Nicole, Flotte, Thomas J., Frisch, Erika, Boysen, Erik M., Welch, Gary, Akintonwa, Teresa, Blancero, Frank, Brown, Heather-Elizabeth, Carmilani, Megan, Cerda, Marta, Clash, Victor H., Copeland, Debra, Hall, Yvonka, kevin kondo, Lerma, Lydia, Lindsay, Jacqui, Marti, Heather, Maughan, Christine, Minor, Tony, Taylor, Brittany, Vincent, Hyatt, Zissis, Mike, Anderson, Brett, Bardhan, Sujata, Castro-Baucom, Leah, Chisolm, Deena, Corchado, Claudia, Damian, April Joy, Daniel, Casey, DasGupta, Soham, Dehority, Walter, Feldman, Candace, Fessel, Josh, Rosas, Lisa Goldman, Horowitz, Carol, Khullar, Dhruv, Lopez, Keila, McDonald Pinkett, Shelly, Myaskovsky, Larissa, Regino, Lidia, St John Thomas, Gelise, Stewart de Ramirez, Sarah, Vangeepuram, Nita, Walden, Anita, Williams, Neely, Yin, Shonna, Burton, Phoebe, Catallozzi, Marina, Clark, Cheryl, Dworetzky, Beth, Edwards, Belinda, Ferrer, Robert L., Judd, Suzanne, Rothman, Russell, Wagner, Laura, Wallace, Ann, Adams, Sonseeahray (Ray), Aragon, Leyna, Bander, Bryan, Bishof, Karyn, Brooks, Gail, Carignan, Etienne, Coombs, Krista, Davis, Hannah, Blakley, Felicia D., Diggs, Marissa, Brown, Heather E., Favors, Umar, Fields, Whitney, Fisher, Liza, Fitzgerald, Megan, Gaffney, Alicia, Witvliet, Margot Gage, Garcia, Roberto, Gustafson, Tyler, Guthe, Nick, Holmes, Verna, Hornig, Mady, Hornig, Maxwell, Jefferson, Wendy, Kochis, Nancy, Kondo, Kevin, Lam, Julie, Lawrence, Fadwa, Letts, Rebecca, Lewis, Juan, Lopez, Silcia, Martinez, Thomas, McCorkell, Lisa, McGrath, Rebecca, Minor, Thomas T., Moore, Charita, Nguyen, Kian, Nichols, Lauren, O'Brien, Lisa, Olson, Holly, Peddie, Aimee, Perlowski, Alice, Lorenzo, Elizabeth P., Prentiss, Lisa, Raytselis, Nadia, Rochez, Nitza, Rockwell, Megan, Rutter, Jacqueline, Seibert, Elle, Sekar, Anisha, Smith, Chimere, Stiles, Lauren, Taylor, Emily, Thompson, Julie, Trapp, Stephen, Valdiva, Stephen, Wilensky, Rochelle, Williams, Melissa, Dawson, Kay W., Wylam, Andrew, Swank, Zoe, Borberg, Ella, Chen, Yulu, Senussi, Yasmeen, Chalise, Sujata, Manickas-Hill, Zachary, Yu, Xu G., Li, Jonathan Z., Alter, Galit, Kelly, J. Daniel, Goldberg, Sarah A., Talla, Aarthi, Li, Xiaojun, Skene, Peter, Bumol, Thomas F., Torgerson, Troy R., Czartoski, Julie L., McElrath, M. Juliana, and Walt, David R.

Published
2024
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17. Symptom Burden and Its Impact on Quality of Life in Patients With Moderate to Severe CKD: The International Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps)

Author

Lopes, Antonio, Pecoits-Filho, Roberto, Combe, Christian, Jacquelinet, Christian, Massy, Ziad, Stengel, Benedicte, Alencar de Pinho, Natalia, Duttlinger, Johannes, Fliser, Danilo, Lonnemann, Gerhard, Reichel, Helmut, Wada, Takashi, Yamagata, Kunihiro, Pisoni, Ron, Robinson, Bruce, Calice da Silva, Viviane, Sesso, Ricardo, Speyer, Elodie, Asahi, Koichi, Hoshino, Junichi, Narita, Ichiei, Perlman, Rachel, Port, Friedrich, Sukul, Nidhi, Wong, Michelle, Young, Eric, Zee, Jarcy, Tu, Charlotte, Lopes, Antonio A., Moutard, Emilie, Omorou, Abdou Y., Stengel, Bénédicte, Finkelstein, Fredric O., de Pinho, Natalia Alencar, and Pisoni, Ronald L.

Published
2024
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19. Alteração climática

Author

Raoni Felipe de Almeida André, Irene Domenes Zapparoli, Umberto Antonio Sesso Filho, and Patrícia Pompermayer Sesso

Subjects
Emissões de CO2eq, Insumo-Produto, Comércio Internacional., Economic growth, development, planning, HD72-88, Economics as a science, HB71-74
Abstract

O objetivo consiste em estimar o efeito que as cadeias produtivas dos países têm de multiplicar as emissões de poluentes e identificar a interdependência dos fluxos de bens e serviços internacionais por meio do índice de ligação Inter-regional. Para tanto utiliza-se a matriz Insumo-Produto ampliada para coeficientes ambientais, agregando-a em 36 países para o ano de 2012. O volume de produção foi extraído do World Input-Output Database (WIOD) e a emissões medidas em dióxido de carbono equivalente (CO2eq) da Organistion For Economic Co-operation and Development (OECD.stat). Os EUA, China, Japão, Alemanha, França, Rússia e Brasil emitiram juntos mais de 76% do volume de emissões de CO­2eq mundial. Os países que apresentam estrutura produtiva com maior grau de multiplicação das emissões de CO2eq são a Suécia, Suíça, Finlândia, Luxemburgo e China. Visto que o aumento de mil toneladas nas emissões de CO2eq nesses países provocam um aumento de 2,59 a 3,66 mil toneladas nas emissões em todos os países pelo efeito em cadeia. A Rússia e a China são as principais economias no encadeamento de insumo intensivos em CO2eq, demandando, respectivamente, 3,2 e 2,9 vezes a mais que a média e ofertando 4,9 e 3,9 vezes a mais que a média.

Published
2024
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20. A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium

Author

Midttun, Øivind, Ulvik, Arve, Meyer, Klaus, Zahed, Hana, Giles, Graham G., Manjer, Jonas, Sandsveden, Malte, Langhammer, Arnulf, Sørgjerd, Elin Pettersen, Behndig, Annelie F., Johansson, Mikael, Freedman, Neal D., Huang, Wen-Yi, Chen, Chu, Prentice, Ross, Stevens, Victoria L., Wang, Ying, Le Marchand, Loïc, Weinstein, Stephanie J., Cai, Qiuyin, Arslan, Alan A., Chen, Yu, Shu, Xiao-Ou, Zheng, Wei, Yuan, Jian-Min, Koh, Woon-Puay, Visvanathan, Kala, Sesso, Howard D., Zhang, Xuehong, Gaziano, J. Michael, Fanidi, Anouar, Robbins, Hilary A., Brennan, Paul, Johansson, Mattias, and Ueland, Per M.

Published
2023
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23. Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS

Author

Vyas, Chirag M, Manson, JoAnn E, Sesso, Howard D, Cook, Nancy R, Rist, Pamela M, Weinberg, Alison, Moorthy, M Vinayaga, Baker, Laura D, Espeland, Mark A, Yeung, Lok-Kin, Brickman, Adam M, and Okereke, Olivia I

Published
2024
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25. Non-Suicidal Self-Injury in Eating and Feeding Disorder Patients: Characteristics and Clinical Implications in a Group of Referred Female Adolescents

Author

Gianluca Sesso, Cristina Mazzullo, Elena Valente, Francesca Ditaranto, Pamela Fantozzi, Vittorio Belmonti, Stefano Berloffa, Francesca Placini, Raffaella Tancredi, Gabriele Masi, and Annarita Milone

Subjects
non-suicidal self-injury, feeding and eating disorders, anorexia nervosa, bulimia nervosa, emotional dysregulation, Pediatrics, RJ1-570
Abstract

Background: Non-suicidal self-injury (NSSI) and Feeding or Eating Disorders (FEDs) often coexist during adolescence with reciprocal influences on their clinical picture. The present study aimed to identify differences and similarities in the clinical presentation of young patients with both conditions compared to those with the two non-comorbid disorders. Methods: We consecutively recruited forty-five female patients aged between 11 and 18 at our third-level hospital and subdivided them into three groups (NSSI: n = 15; FED: n = 15; NSSI + FED: n = 15). Patients underwent a full clinical assessment. Results: Based on our results, the NSSI + FED group was characterized by higher rates of binging/purging behaviors, greater prevalence of Cyclothymic Disorder, and a more severe clinical presentation compared to the non-comorbid groups. Moreover, higher levels of suicidal ideation were found in the NSSI + FED group. Pharmacological treatment patterns also differed, with SSRI being prescribed more frequently to NSSI + FED patients while mood stabilizers were prescribed more frequently to NSSI ones. A Principal Component Analysis identified four main dimensions: “Body Image” impairment was more pronounced in NSSI + FED patients, indicating negative attitudes towards their own body; “Metacognition” deficits were higher in NSSI than FED. Conclusions: The present study underscores distinctive clinical features in patients with comorbid NSSI and FED, emphasizing the urgent need for tailored intervention strategies focusing on specific symptom domains.

Published
2024
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29. Prediagnostic Inflammation and Pancreatic Cancer Survival.

Author

Yuan, Chen, Morales-Oyarvide, Vicente, Khalaf, Natalia, Perez, Kimberly, Tabung, Fred K, Ho, Gloria YF, Kooperberg, Charles, Shadyab, Aladdin H, Qi, Lihong, Kraft, Peter, Sesso, Howard D, Giovannucci, Edward L, Manson, JoAnn E, Stampfer, Meir J, Ng, Kimmie, Fuchs, Charles S, Wolpin, Brian M, and Babic, Ana

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Rare Diseases, Cancer, Pancreatic Cancer, Digestive Diseases, Humans, Inflammation, Pancreatic Neoplasms, Proportional Hazards Models, Prospective Studies, Risk Factors, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundChronic inflammation may promote initiation and progression of pancreatic cancer, but no studies have examined the association between inflammation in the period before diagnosis and pancreatic cancer survival.MethodsWe prospectively examined the association of prediagnostic plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α receptor 2 with survival among 492 participants from 5 large US prospective cohort studies who developed pancreatic cancer. Using an empirical dietary inflammatory pattern (EDIP) score, we evaluated whether long-term proinflammatory diets were associated with survival among 1153 patients from 2 of the 5 cohorts. Cox proportional hazards regression was used to estimate hazard ratios for death with adjustment for potential confounders. All statistical tests were 2-sided.ResultsHigher prediagnostic levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α receptor 2 were individually associated with reduced survival (Ptrend = .03, .01, and .04, respectively). Compared with patients with a combined inflammatory biomarker score of 0 (all 3 marker levels below medians), those with a score of 3 (all 3 marker levels above medians) had a hazard ratio for death of 1.57 (95% confidence interval = 1.16 to 2.12; Ptrend = .003), corresponding to median overall survival times of 8 vs 5 months. Patients consuming the most proinflammatory diets (EDIP quartile 4) in the prediagnostic period had a hazard ratio for death of 1.34 (95% confidence interval = 1.13 to 1.59; Ptrend = .01), compared with those consuming the least proinflammatory diets (EDIP quartile 1).ConclusionPrediagnostic levels of inflammatory biomarkers and long-term proinflammatory diets were inversely associated with pancreatic cancer survival.

Published
2021

32. CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD

Author

Lopes, Antonio, Pecoits-Filho, Roberto, Combe, Christian, Jacquelinet, Christian, Massy, Ziad, Stengel, Benedicte, Duttlinger, Johannes, Fliser, Danilo, Lonnemann, Gerhard, Reichel, Helmut, Wada, Takashi, Yamagata, Kunihiro, Pisoni, Ron, Robinson, Bruce, Calice da Silva, Viviane, Sesso, Ricardo, Speyer, Elodie, Asahi, Koichi, Hoshino, Junichi, Narita, Ichiei, Perlman, Rachel, Port, Friedrich, Sukul, Nidhi, Wong, Michelle, Young, Eric, Zee, Jarcy, Scherer, Jennifer S., Tu, Charlotte, Pisoni, Ronald L., Lopes, Antonio A., Wen, Warren, Menzaghi, Frederique, Cirulli, Joshua, Alencar de Pinho, Natalia, and Karaboyas, Angelo

Published
2024
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34. O COMÉRCIO DE VALOR ADICIONADO E A PARTICIPAÇÃO DO BRASIL NAS CADEIAS GLOBAIS DE VALOR/The value-added trade and the participation of Brazil in global value chains

Author

Carlos Alberto Gonçalves Junior, Cassia Girotto, Ricardo Luis Lopes, and Umberto Antonio Sesso Filho

Subjects
Valor Adicionado Doméstico, Cadeias Globais de Valor, Sistema Global de Insumo Produto, TiVA, Desenvolvimento Regional, Agriculture (General), S1-972, Agricultural industries, HD9000-9495
Abstract

O presente artigo tem como objetivo analisar a evolução do comércio de Valor Adicionado Doméstico - VAD brasileiro, assim como participação do Brasil nas Cadeias Globais de Valor - CGVs, considerando os seus principais parceiros comerciais, por meio dos indicadores Trade in value-added – TiVA e das matrizes mundiais de insumo-produto Inter-Country Input-Output Tables – ICIO release 2018, disponibilizadas pela Organisation for Economic Co-operation e Development – OECD. Os resultados mostram que os produtos exportados pelo Brasil para União Europeia, China e Coréia do Sul apresentam maior proporção de VAD, em relação ao total das exportações. No entanto, são produtos com baixo valor adicionado em termos absolutos, pois são, em sua maioria, exportados in natura ou semielaborados. Já os produtos exportados pelo Brasil para Argentina, México, e a região Andina, apresentam menor proporção de VAD em relação ao valor total das exportações, contudo, são produtos de alta e média tecnologia que utilizam processos mais elaborados em sua produção e abrem mais espaço para inserção de conteúdo importado, o que corrobora para a maior inserção do Brasil nas CGVs. Além disso, apresentam maior valor adicionado em termos absolutos. Abstract: The aim of this paper is to analyze the evolution of Brazilian Domestic Value Added - DVA trade, as well as Brazil's participation in Global Value Chains - CGVs, considering the Brazilian main trading partners, through the Trade in value-added indicators - TiVA and the Inter-Country Input-Output Tables - ICIO, release 2018, made available by the Organization for Economic Co-operation and Development – OECD. The results show that products exported by Brazil to the European Union, China and South Korea have a higher proportion of DVA in relation to total exports. However, they are low value-added products in absolute terms, as they are mostly exported in natura or semi-processed. On the other hand, Products exported by Brazil to Argentina, Mexico, and the Andean region, have a lower proportion of DVA in relation to the total value of exports, however, they are high and medium technology products that use more elaborate processes in their production and make room for insertion of imported content, which corroborates for the greater insertion of Brazil in the GVCs. In addition, they have higher value added in absolute terms.

Published
2024
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35. Key Performance Indicators of Secondary Health Care in Chronic Kidney Disease: Experience in Public and Private Services in the State of São Paulo, Brazil

Author

Farid Samaan, Cristiane Akemi Vicente, Luiz Antônio Coutinho Pais, Gianna Mastroianni Kirsztajn, and Ricardo Sesso

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Conclusions: Quality of care for patients with CKD can be improved through both services, and multidisciplinary care may have a positive impact on the control of comorbidities, the progression of CKD, and the planning of the initiation of hemodialysis.

Published
2024
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36. CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD

Author

Jennifer S. Scherer, Charlotte Tu, Ronald L. Pisoni, Elodie Speyer, Antonio A. Lopes, Warren Wen, Frederique Menzaghi, Joshua Cirulli, Natalia Alencar de Pinho, Roberto Pecoits-Filho, Angelo Karaboyas, Antonio Lopes, Christian Combe, Christian Jacquelinet, Ziad Massy, Benedicte Stengel, Johannes Duttlinger, Danilo Fliser, Gerhard Lonnemann, Helmut Reichel, Takashi Wada, Kunihiro Yamagata, Ron Pisoni, Bruce Robinson, Viviane Calice da Silva, Ricardo Sesso, Koichi Asahi, Junichi Hoshino, Ichiei Narita, Rachel Perlman, Friedrich Port, Nidhi Sukul, Michelle Wong, Eric Young, and Jarcy Zee

Subjects
Chronic kidney disease, hospitalization, mortality, pruritus, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Rationale & Objective: Itching is a frequent symptom experienced by people with chronic kidney disease (CKD). We investigated the associations of CKD-associated pruritus (CKD-aP) with clinical outcomes. Study Design: This was a longitudinal cohort study. Setting & Participants: Patients from Brazil, France, and the United States enrolled in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps) from 2013 to 2021, an international prospective cohort study of adults with nondialysis dependent CKD, and an estimated glomerular filtration rate (eGFR) of

Published
2024
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37. Brazilian Dialysis Survey 2022

Author

Fabiana Baggio Nerbass, Helbert do Nascimento Lima, José Andrade Moura-Neto, Jocemir Ronaldo Lugon, and Ricardo Sesso

Subjects
Renal Dialysis, Peritoneal Dialysis, Epidemiology, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Introduction: The Brazilian Dialysis Survey (BDS) is an annual national survey about patients on chronic dialysis that contributes to health policies. Objective: To report the 2022 epidemiological data from the BDS of the Brazilian Society of Nephrology (BSN). Methods: A survey was carried out in Brazilian chronic dialysis centers using an online questionnaire that included clinical and epidemiological aspects of patients on chronic dialysis, dialysis therapy data, and dialysis center characteristics. Results: Overall, 28% (n = 243) of the centers answered the questionnaire. In July 2022, the estimated total number of patients on dialysis was 153,831. The estimated prevalence and incidence rates of patients per million population (pmp) were 758 and 214, respectively. Of the prevalent patients, 95.3% were on hemodialysis (HD, 4.6% of these on hemodiafiltration) and 4.7% on peritoneal dialysis (PD). Only 1.3% of patients were not vaccinated against COVID-19. The prevalence of anemia (Hb < 10g/dL) was 27% and hyperphosphatemia (P > 5.5mg/dL) reached 30%. The estimated overall crude annual mortality rate was 17.1%. Conclusions: The absolute number and prevalence rate of patients on chronic dialysis continue to increase. A growing number of patients were receiving hemodiafiltration. The mortality rate decreased, probably due to the end of COVID-19 pandemic. The conclusions were drawn in the context of relatively low voluntary participation, which imposed methodological limitations on our estimates.

Published
2023
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38. Estimação do sistema interregional de insumo-produto Maringá-Paraná-restante do Brasil, 2018: diagnóstico do mercado de trabalho maringaense

Author

Cleverson Neves, Marina Silva Cunha, and Umberto Antonio Sesso Filho

Subjects
Insumo-produto, Mercado de trabalho, Escolaridade, Qualificação, Maringá, Human ecology. Anthropogeography, GF1-900, Physical geography, GB3-5030, Geography (General), G1-922
Abstract

O objetivo do estudo foi estimar a geração de empregos direta e indireta por nível de qualificação nos setores da cidade de Maringá, bem como, o efeito exportação de empregos para o restante dos municípios do Paraná e também do restante do Brasil para o ano de 2018, pois identificar tais setores da cadeia produtiva que mais exportam empregos pode ser uma ferramenta estrategicamente importante para a promoção e fomento do desenvolvimento regional apartir do instrumental metodológico de insumo-produto. Os resultados mostraram que as maiores participações no emprego total da economia maringaense estiveram nos setores (19) Serviços, (15) Comércio, (20) Administração Pública, (16) Transportes e (11) Industria de Alimentos. As aquisições de insumos de fora da região de origem causaram maiores valores de efeito exportação de empregos para os setores (11) Industria de Alimentos, (1) Agropecuária, (9) Industria Têxtil, (8) Ind. Química e Farmacêutica e (6) Celulose, Papel e Gráfica. Nesse particular, estudos mais detalhados poderão ser realizados para avaliar a viabilidade de se desenvolver no município a capacidade de ofertar insumos antes importados. Os resultados da pesquisa podem ser utilizados pelo setor educação (pública e privada) para adequar a oferta de trabalho qualificado para diminuir a ocorrência de fuga de cérebros do município ou necessidade de atrair profissionais de outras localidades.

Published
2023
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39. Gross Domestic Product and water footprint of agribusiness: comparative between countries.

Author

Sesso Filho, Umberto Antonio, Luís Lopes, Ricardo, Gonçalves Junior, Carlos Alberto, Zuan Esteves, Emerson Guzzi, and Pompermayer Sesso, Patrícia

Abstract

Copyright of Revista de Economia e Sociologia Rural is the property of Sociedade Brasileira de Economia e Sociologia Rural and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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44. Endogenous sex steroid hormones and risk of liver cancer among US men: Results from the Liver Cancer Pooling Project

Author

Wu, Zeni, Petrick, Jessica L., Florio, Andrea A., Guillemette, Chantal, Beane Freeman, Laura E., Buring, Julie E., Bradwin, Gary, Caron, Patrick, Chen, Yu, Eliassen, A. Heather, Engel, Lawrence S., Freedman, Neal D., Gaziano, J. Michael, Giovannuci, Edward L., Hofmann, Jonathan N., Huang, Wen-Yi, Kirsh, Victoria A., Kitahara, Cari M., Koshiol, Jill, Lee, I-Min, Liao, Linda M., Newton, Christina C., Palmer, Julie R., Purdue, Mark P., Rohan, Thomas E., Rosenberg, Lynn, Sesso, Howard D., Sinha, Rashmi, Stampfer, Meir J., Um, Caroline Y., Van Den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Graubard, Barry I., Campbell, Peter T., and McGlynn, Katherine A.

Published
2023
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45. Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project

Author

Florio, Andrea A, Campbell, Peter T, Zhang, Xuehong, Zeleniuch‐Jacquotte, Anne, Wactawski‐Wende, Jean, Smith‐Warner, Stephanie A, Sinha, Rashmi, Simon, Tracey G, Sesso, Howard D, Schairer, Catherine, Rosenberg, Lynn, Rohan, Thomas E, Robien, Kim, Renehan, Andrew G, Purdue, Mark P, Poynter, Jenny N, Palmer, Julie R, Newton, Christina C, Lu, Yunxia, Linet, Martha S, Liao, Linda M, Lee, I‐Min, Koshiol, Jill, Kitahara, Cari M, Kirsh, Victoria A, Hofmann, Jonathan N, Graubard, Barry I, Giovannucci, Edward, Gaziano, John M, Gapstur, Susan M, Freedman, Neal D, Demuth, Jane, Chong, Dawn Q, Chan, Andrew T, Buring, Julie E, Bradshaw, Patrick T, Freeman, Laura E Beane, McGlynn, Katherine A, and Petrick, Jessica L

Subjects
Obesity, Rare Diseases, Cancer, Liver Disease, Digestive Diseases, Clinical Research, Liver Cancer, Prevention, Adiposity, Adult, Aged, Bile Duct Neoplasms, Body Mass Index, Carcinoma, Hepatocellular, Cholangiocarcinoma, Female, Humans, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Waist Circumference, Waist-Hip Ratio, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, abdominal obesity, gluteofemoral obesity, epidemiology, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type-hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC n = 1,154, ICC n = 335). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Waist circumference, per 5 cm increase, was associated with an 11% increased PLC risk (HR = 1.11, 95%CI: 1.09-1.14), including when adjusted for hip circumference (HR = 1.12, 95%CI: 1.08-1.17) and also when restricted to individuals in a normal body mass index (BMI) range (18.5 to

Published
2020

46. Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank

Author

Petrick, Jessica L, McMenamin, Úna C, Zhang, Xuehong, Zeleniuch-Jacquotte, Anne, Wactawski-Wende, Jean, Simon, Tracey G, Sinha, Rashmi, Sesso, Howard D, Schairer, Catherine, Rosenberg, Lynn, Rohan, Thomas E, Robien, Kim, Purdue, Mark P, Poynter, Jenny N, Palmer, Julie R, Lu, Yunxia, Linet, Martha S, Liao, Linda M, Lee, I-Min, Koshiol, Jill, Kitahara, Cari M, Kirsh, Victoria A, Hofmann, Jonathan N, Graubard, Barry I, Giovannucci, Edward, Gaziano, J Michael, Gapstur, Susan M, Freedman, Neal D, Florio, Andrea A, Chong, Dawn Q, Chen, Yu, Chan, Andrew T, Buring, Julie E, Freeman, Laura E Beane, Bea, Jennifer W, Cardwell, Christopher R, Campbell, Peter T, and McGlynn, Katherine A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Liver Disease, Cancer, Digestive Diseases, Contraception/Reproduction, Clinical Research, Digestive Diseases - (Gallbladder), Liver Cancer, Prevention, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Good Health and Well Being, Aged, Bile Ducts, Bile Ducts, Intrahepatic, Biological Specimen Banks, Cholangiocarcinoma, Cohort Studies, Contraceptives, Oral, Hormonal, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Gene Expression Regulation, Neoplastic, Hormones, Humans, Hysterectomy, Liver Neoplasms, Menopause, Middle Aged, Proportional Hazards Models, Risk Factors, United Kingdom, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundIntrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both oestrogen receptor-α and -β, and oestrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating oestradiol is associated with increased ICC risk, further supporting a hormonal aetiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC.MethodsWe harmonised data from 1,107,498 women who enroled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from the LCPP (n = 180 cases) and the UK Biobank (n = 57 cases).ResultsHysterectomy was associated with a doubling of ICC risk (HR = 1.98, 95% CI: 1.27-3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR = 1.62, 95% CI: 1.03-2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors.ConclusionsThis study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

Published
2020

47. A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium

Author

Øivind Midttun, Arve Ulvik, Klaus Meyer, Hana Zahed, Graham G. Giles, Jonas Manjer, Malte Sandsveden, Arnulf Langhammer, Elin Pettersen Sørgjerd, Annelie F. Behndig, Mikael Johansson, Neal D. Freedman, Wen-Yi Huang, Chu Chen, Ross Prentice, Victoria L. Stevens, Ying Wang, Loïc Le Marchand, Stephanie J. Weinstein, Qiuyin Cai, Alan A. Arslan, Yu Chen, Xiao-Ou Shu, Wei Zheng, Jian-Min Yuan, Woon-Puay Koh, Kala Visvanathan, Howard D. Sesso, Xuehong Zhang, J. Michael Gaziano, Anouar Fanidi, Hilary A. Robbins, Paul Brennan, Mattias Johansson, and Per M. Ueland

Subjects
Medicine, Science
Abstract

Abstract Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin and the kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, and together with C-reactive protein (CRP) and kynurenines they are associated with various diseases, but comprehensive data on the strength of associations of inflammatory markers with circulating concentrations of kynurenines are lacking. We measured circulating concentrations of neopterin, CRP, tryptophan and seven kynurenines in 5314 controls from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). The associations of neopterin, KTR and CRP with kynurenines were investigated using regression models. In mixed models, one standard deviation (SD) higher KTR was associated with a 0.46 SD higher quinolinic acid (QA), and 0.31 SD higher 3-hydroxykynurenine (HK). One SD higher neopterin was associated with 0.48, 0.44, 0.36 and 0.28 SD higher KTR, QA, kynurenine and HK, respectively. KTR and neopterin respectively explained 24.1% and 16.7% of the variation in QA, and 11.4% and 7.5% of HK. CRP was only weakly associated with kynurenines in regression models. In summary, QA was the metabolite that was most strongly associated with the inflammatory markers. In general, the inflammatory markers were most strongly related to metabolites located along the tryptophan–NAD axis, which may support suggestions of increased production of NAD from tryptophan during inflammation.

Published
2023
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