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3. Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI

Author

Vallejo-Vaz, Antonio J., Bray, Sarah, Villa, Guillermo, Brandts, Julia, Kiru, Gaia, Murphy, Jennifer, Banach, Maciej, De Servi, Stefano, Gaita, Dan, Gouni-Berthold, Ioanna, Kees Hovingh, G., Jozwiak, Jacek J., Jukema, J. Wouter, Gabor Kiss, Robert, Kownator, Serge, Iversen, Helle K., Maher, Vincent, Masana, Luis, Parkhomenko, Alexander, Peeters, André, Clifford, Piers, Raslova, Katarina, Siostrzonek, Peter, Romeo, Stefano, Tousoulis, Dimitrios, Vlachopoulos, Charalambos, Vrablik, Michal, Catapano, Alberico L., Poulter, Neil R., and Ray, Kausik K.

Published
2023
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7. Impact of hemoglobin levels at admission on outcomes among elderly patients with acute coronary syndrome treated with low-dose Prasugrel or clopidogrel: A sub-study of the ELDERLY ACS 2 trial

Author

De Luca, Giuseppe, Verdoia, Monica, Morici, Nuccia, Ferri, Luca A., Piatti, Luigi, Grosseto, Daniele, Bossi, Irene, Sganzerla, Paolo, Tortorella, Giovanni, Cacucci, Michele, Ferrario, Maurizio, Murena, Ernesto, Tondi, Stefano, Toso, Anna, Bongioanni, Sergio, Ravera, Amelia, Corrada, Elena, Mariani, Matteo, Di Ascenzo, Leonardo, Petronio, A. Sonia, Cavallini, Claudio, Vitrella, Giancarlo, Antonicelli, Roberto, Cesana, Bruno M., De Luca, Leonardo, Ottani, Filippo, Moffa, Nadia, Savonitto, Stefano, and De Servi, Stefano

Published
2022
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9. Older women with non-ST-elevation acute coronary syndrome undergoing invasive or conservative management: an individual patient data meta-analysis.

Author

Rubino, Francesca, Pompei, Graziella, Mills, Gregory B, Kotanidis, Christos P, Laudani, Claudio, Bendz, Bjørn, Berg, Erlend S, Hildick-Smith, David, Hirlekar, Geir, Morici, Nuccia, Myat, Aung, Tegn, Nicolai, Forés, Juan Sanchis, Savonitto, Stefano, Servi, Stefano De, and Kunadian, Vijay

Subjects
ACUTE coronary syndrome, OLDER women, OLDER patients, MYOCARDIAL infarction, CARDIOVASCULAR disease related mortality
Abstract

Aims Women and older patients are underrepresented in randomized controlled trials (RCTs) investigating treatment strategies following acute coronary syndrome. This study aims to evaluate the benefit of invasive vs. conservative strategy of older women with non-ST-elevation acute coronary syndrome (NSTEACS). Methods and results This analysis from an individual patient data meta-analysis included six RCTs comparing an invasive management with a conservative management in older NSTEACS patients. The primary endpoint was the composite of all-cause mortality or myocardial infarction (MI). Secondary endpoints included all-cause mortality, cardiovascular death, MI, urgent revascularization, and stroke. Follow-up time was censored at 1 year. In total, 717 women [median age 84.0 (interquartile range 81.0–87.0) years] were included. The primary endpoint occurred in 21.0% in the invasive strategy vs. 27.8% in the conservative strategy [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.52–1.13, P = 0.160 using random effect] at 1-year follow-up. The invasive management was associated with reduced risk of MI (HR 0.49, 95% CI 0.32–0.73, P < 0.001) and urgent revascularization (HR 0.44, 95% CI 0.20–0.98, P = 0.045). No significant differences were identified in the risk of all-cause mortality, cardiovascular death, and stroke. Among males, there was no significant association between the treatment strategy and primary or secondary endpoints. Conclusion An invasive strategy compared with a conservative strategy did not reduce the composite outcome of all-cause mortality or MI in older NSTEACS women at 1-year follow-up. An invasive strategy reduced the individual risk of MI and urgent revascularization. Our results support the beneficial role of the invasive strategy in older NSTEACS women. Registration This meta-analysis is registered with PROSPERO (CRD42023379819). [ABSTRACT FROM AUTHOR]

Published
2024
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11. Association of Sex with Outcome in Elderly Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Author

De Rosa, Roberta, Morici, Nuccia, De Luca, Giuseppe, De Luca, Leonardo, Ferri, Luca A., Piatti, Luigi, Tortorella, Giovanni, Grosseto, Daniele, Franco, Nicoletta, Misuraca, Leonardo, Sganzerla, Paolo, Cacucci, Michele, Antonicelli, Roberto, Cavallini, Claudio, Lenatti, Laura, Leuzzi, Chiara, Murena, Ernesto, Ravera, Amelia, Ferrario, Maurizio, Corrada, Elena, Colombo, Delia, Prati, Francesco, Piscione, Federico, Petronio, A. Sonia, Galasso, Gennaro, De Servi, Stefano, and Savonitto, Stefano

Published
2021
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13. Residual SYNTAX Score and One-Year Outcome in Elderly Patients With Acute Coronary Syndrome

Author

Morici, Nuccia, Alicandro, Gianfranco, Ferri, Luca A., Piatti, Luigi, Grosseto, Daniele, Sganzerla, Paolo, Tortorella, Giovanni, Ferrario, Maurizio, Crimi, Gabriele, Bossi, Irene, Tondi, Stefano, Petronio, Anna Sonia, Mariani, Matteo, Toso, Anna, Ravera, Amelia, Corrada, Elena, Cao, Davide, Di Ascenzo, Leonardo, La Vecchia, Carlo, De Servi, Stefano, and Savonitto, Stefano

Published
2020
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15. Characteristics and Outcome of Patients ≥75 Years of Age With Prior Coronary Artery Bypass Grafting Admitted for an Acute Coronary Syndrome

Author

Morici, Nuccia, De Rosa, Roberta, Crimi, Gabriele, De Luca, Leonardo, Ferri, Luca A., Lenatti, Laura, Piatti, Luigi, Tortorella, Giovanni, Grosseto, Daniele, Franco, Nicoletta, Bossi, Irene, Montalto, Claudio, Antonicelli, Roberto, Alicandro, Gianfranco, De Luca, Giuseppe, De Servi, Stefano, and Savonitto, Stefano

Published
2020
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16. Percutaneous Coronary Intervention Techniques for Bifurcation Disease: Network Meta-analysis Reveals Superiority of Double-Kissing Crush

Author

Crimi, Gabriele, Mandurino-Mirizzi, Alessandro, Gritti, Valeria, Scotti, Valeria, Strozzi, Clara, de Silvestri, Annalisa, Montalto, Claudio, di Giacomo, Ciro, d’Ascenzo, Fabrizio, Repetto, Alessandra, Ferlini, Marco, Marinoni, Barbara, Ferrario, Maurizio, de Servi, Stefano, Visconti, Luigi Oltrona, and Klersy, Catherine

Published
2020
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17. Impact of body mass index on clinical outcome among elderly patients with acute coronary syndrome treated with percutaneous coronary intervention: Insights from the ELDERLY ACS 2 trial

Author

De Luca, Giuseppe, Verdoia, Monica, Savonitto, Stefano, Ferri, Luca A., Piatti, Luigi, Grosseto, Daniele, Morici, Nuccia, Bossi, Irene, Sganzerla, Paolo, Tortorella, Giovanni, Cacucci, Michele, Ferrario, Maurizio, Murena, Ernesto, Sibilio, Girolamo, Tondi, Stefano, Toso, Anna, Bongioanni, Sergio, Ravera, Amelia, Corrada, Elena, Mariani, Matteo, Di Ascenzo, Leonardo, Petronio, A. Sonia, Cavallini, Claudio, Vitrella, Giancarlo, Antonicelli, Roberto, Rogacka, Renata, and De Servi, Stefano

Published
2020
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20. Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis

Author

Kotanidis, Christos P, primary, Mills, Gregory B, additional, Bendz, Bjørn, additional, Berg, Erlend S, additional, Hildick-Smith, David, additional, Hirlekar, Geir, additional, Milasinovic, Dejan, additional, Morici, Nuccia, additional, Myat, Aung, additional, Tegn, Nicolai, additional, Sanchis, Juan, additional, Savonitto, Stefano, additional, De Servi, Stefano, additional, Fox, Keith A A, additional, Pocock, Stuart, additional, and Kunadian, Vijay, additional

Published
2024
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21. Outcomes of Elderly Patients with ST-Elevation or Non-ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Author

Morici, Nuccia, Savonitto, Stefano, Ferri, Luca A., Grosseto, Daniele, Bossi, Irene, Sganzerla, Paolo, Tortorella, Giovanni, Cacucci, Michele, Ferrario, Maurizio, Crimi, Gabriele, Murena, Ernesto, Tondi, Stefano, Toso, Anna, Gandolfo, Nicola, Ravera, Amelia, Corrada, Elena, Mariani, Matteo, Di Ascenzo, Leonardo, Petronio, A. Sonia, Cavallini, Claudio, Vitrella, Giancarlo, Antonicelli, Roberto, Piscione, Federico, Rogacka, Renata, Antolini, Laura, Alicandro, Gianfranco, La Vecchia, Carlo, Piatti, Luigi, and De Servi, Stefano

Published
2019
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24. Derivation and validation of the incomplete ST-segment resolution score and its usefulness for treatment with glycoprotein IIb-IIIa inhibitors

Author

Cornara, Stefano, primary, Mandurino-Mirizzi, Alessandro, additional, Somaschini, Alberto, additional, Mauri, Silvia, additional, Crimi, Gabriele, additional, Munafò, Andrea, additional, Camporotondo, Rita, additional, Gnecchi, Massimiliano, additional, De Servi, Stefano, additional, De Ferrari, Gaetano Maria, additional, and Ferlini, Marco, additional

Published
2023
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26. Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial

Author

Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Presbitero, Patrizia, Zavalloni-Parenti, Dennis, Ferrari, Fabio, Ceravolo, Roberto, Tarantino, Fabio, Pasquetto, Giampaolo, Casu, Gavino, Mameli, Stefano, Stochino, Maria Letizia, Mazzarotto, Pietro, Cremonesi, Alberto, Saia, Francesco, Saccone, Giovanni, Abate, Fabio, Picchi, Andrea, Violini, Roberto, Colangelo, Salvatore, Boccuzzi, Giacomo, Guiducci, Vincenzo, Vigna, Carlo, Zingarelli, Antonio, Gagnor, Andrea, Zaro, Tiziana, Tresoldi, Simone, Vandoni, Pietro, Contarini, Marco, Liso, Armando, Dellavalle, Antonio, Curello, Salvatore, Mangiacapra, Fabio, Evola, Rosario, Palmieri, Cataldo, Falcone, Camillo, Liistro, Francesco, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Perkan, Andrea, De Servi, Stefano, Fischetti, Dionigi, Rigattieri, Stefano, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, De Caterina, Raffaele, Caputo, Marcello, Zimmarino, Marco, Bramucci, Ezio, Di Lorenzo, Emilio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Loi, Bruno, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Micari, Antonio, Belloni, Flavia, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Klinieken, Isala, Van Mieghem, Nicolas, Diletti, Roberto, Regar, Evelyn, Sabaté, Manel, Gómez Hospital, Joan Antoni, Díaz Fernández, José Francisco, Mainar, Vicente, de la Torre Hernandez, Jose Maria, Valgimigli, Marco, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Rothenbühler, Martina, Tebaldi, Matteo, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Rubartelli, Paolo, Briguori, Carlo, Andó, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, de Cesare, Nicoletta, Tosi, Paolo, van 't Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, Heg, Dik, and Jüni, Peter

Published
2018
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27. High on-treatment platelet reactivity and outcome in elderly with non ST-segment elevation acute coronary syndrome - Insight from the GEPRESS study

Author

De Rosa, Roberta, Palmerini, Tullio, De Servi, Stefano, Belmonte, Marta, Crimi, Gabriele, Cornara, Stefano, Calabrò, Paolo, Cattaneo, Marco, Maffeo, Diego, Toso, Anna, Bartorelli, Antonio, Palmieri, Cataldo, De Carlo, Marco, Capodanno, Davide, Genereux, Philippe, Angiolillo, Dominick, Piscione, Federico, and Galasso, Gennaro

Published
2018
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28. Lack of implementation of guidelines recommendations for coronary revascularization in stable patients with complex disease is associated with high rates of incomplete revascularization: Analysis from the Apache study

Author

Marino, Marcello, Leonardi, Sergio, Crimi, Gabriele, Ferrario, Maurizio, Musumeci, Giuseppe, Tarantini, Giuseppe, Lettieri, Corrado, Bettari, Luca, Maddalena, Lettino, De Luca, Leonardo, Varbella, Ferdinando, and De Servi, Stefano

Published
2020
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32. Beneficial Effects of IABP in Anterior Myocardial Infarction Complicated by Cardiogenic Shock

Author

Somaschini, Alberto, primary, Cornara, Stefano, additional, Leonardi, Sergio, additional, Demarchi, Andrea, additional, Mandurino-Mirizzi, Alessandro, additional, Fortuni, Federico, additional, Ferlini, Marco, additional, Crimi, Gabriele, additional, Camporotondo, Rita, additional, Gnecchi, Massimiliano, additional, Oltrona Visconti, Luigi, additional, De Servi, Stefano, additional, and De Ferrari, Gaetano Maria, additional

Published
2023
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35. Patients with non-ST segment elevation acute coronary syndromes managed without coronary revascularization: A population needing treatment improvement

Author

Menozzi, Alberto, De Servi, Stefano, Rossini, Roberta, Ferlini, Marco, Lina, Daniela, Abrignani, Maurizio Giuseppe, Capranzano, Piera, Carrabba, Nazario, Galvani, Marcello, Marchese, Alfredo, Mazzotta, Gianfranco, Moretti, Luciano, Signore, Nicola, Uguccioni, Massimo, Olivari, Zoran, and De Luca, Leonardo

Published
2017
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36. Comparison of Outcomes of Staged Complete Revascularization Versus Culprit Lesion–Only Revascularization for ST-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease

Author

Marino, Marcello, Crimi, Gabriele, Leonardi, Sergio, Ferlini, Marco, Repetto, Alessandra, Camporotondo, Rita, Demarchi, Andrea, De Pascali, Ilaria, Falcinella, Francesca, Oltrona Visconti, Luigi, De Servi, Stefano, Ferrario, Maurizio, De Ferrari, Gaetano Maria, and Gnecchi, Massimiliano

Published
2017
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38. Impact of diabetes on clinical outcome among elderly patients with acute coronary syndrome treated with percutaneous coronary intervention: insights from the ELDERLY ACS 2 trial

Author

De Luca, Giuseppe, Verdoia, Monica, Savonitto, Stefano, Piatti, Luigi, Grosseto, Daniele, Morici, Nuccia, Bossi, Irene, Sganzerla, Paolo, Tortorella, Giovanni, Cacucci, Michele, Murena, Ernesto, Toso, Anna, Bongioanni, Sergio, Ravera, Amelia, Corrada, Elena, Mariani, Matteo, Di Ascenzo, Leonardo, Petronio, Anna S., Cavallini, Claudio, Vitrella, Giancarlo, Antonicelli, Roberto, Rogacka, Renata, and De Servi, Stefano

Published
2020
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42. A comparison of reduced-dose prasugrel and standard-dose clopidogrel in elderly patients with acute coronary syndromes undergoing early percutaneous revascularization: Design and rationale of the randomized Elderly-ACS 2 study

Author

Ferri, Luca A., Morici, Nuccia, Grosseto, Daniele, Tortorella, Giovanni, Bossi, Irene, Sganzerla, Paolo, Cacucci, Michele, Sibilio, Girolamo, Tondi, Stefano, Toso, Anna, Ferrario, Maurizio, Gandolfo, Nicola, Ravera, Amelia, Mariani, Matteo, Corrada, Elena, Di Ascenzo, Leonardo, Petronio, Anna Sonia, Cavallini, Claudio, Moffa, Nadia, De Servi, Stefano, and Savonitto, Stefano

Published
2016
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50. Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD:A Simulation Study From DA VINCI

Author

Vallejo-Vaz, Antonio J, Bray, Sarah, Villa, Guillermo, Brandts, Julia, Kiru, Gaia, Murphy, Jennifer, Banach, Maciej, De Servi, Stefano, Gaita, Dan, Gouni-Berthold, Ioanna, Kees Hovingh, G., Jozwiak, Jacek J., Jukema, J. Wouter, Gabor Kiss, Robert, Kownator, Serge, Iversen, Helle K., Maher, Vincent, Masana, Luis, Parkhomenko, Alexander, Peeters, André, Clifford, Piers, Raslova, Katarina, Siostrzonek, Peter, Romeo, Stefano, Tousoulis, Dimitrios, Vlachopoulos, Charalambos, Vrablik, Michal, Catapano, Alberico L., Poulter, Neil R., Ray, Kausik K., Vallejo-Vaz, Antonio J, Bray, Sarah, Villa, Guillermo, Brandts, Julia, Kiru, Gaia, Murphy, Jennifer, Banach, Maciej, De Servi, Stefano, Gaita, Dan, Gouni-Berthold, Ioanna, Kees Hovingh, G., Jozwiak, Jacek J., Jukema, J. Wouter, Gabor Kiss, Robert, Kownator, Serge, Iversen, Helle K., Maher, Vincent, Masana, Luis, Parkhomenko, Alexander, Peeters, André, Clifford, Piers, Raslova, Katarina, Siostrzonek, Peter, Romeo, Stefano, Tousoulis, Dimitrios, Vlachopoulos, Charalambos, Vrablik, Michal, Catapano, Alberico L., Poulter, Neil R., and Ray, Kausik K.

Abstract

Purpose: Low-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association (ACC/AHA) and 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (< 70 vs. < 55 mg/dl, respectively). In the DA VINCI study, residual cardiovascular risk was predicted in ASCVD patients. The extent to which relative and absolute risk might be lowered by achieving ACC/AHA versus ESC/EAS LDL-C recommended approaches was simulated. Methods: DA VINCI was a cross-sectional observational study of patients prescribed lipid-lowering therapy (LLT) across 18 European countries. Ten-year cardiovascular risk (CVR) was predicted among ASCVD patients receiving stabilized LLT. For patients with LDL-C ≥ 70 mg/dl, the absolute LDL-C reduction required to achieve an LDL-C of < 70 or < 55 mg/dl (LDL-C of 69 or 54 mg/dl, respectively) was calculated. Relative and absolute risk reductions (RRRs and ARRs) were simulated. Results: Of the 2039 patients, 61% did not achieve LDL-C < 70 mg/dl. For patients with LDL-C ≥ 70 mg/dl, median (interquartile range) baseline LDL-C and 10-year CVR were 93 (81–115) mg/dl and 32% (25–43%), respectively. Median LDL-C reductions of 24 (12–46) and 39 (27–91) mg/dl were needed to achieve an LDL-C of 69 and 54 mg/dl, respectively. Attaining ACC/AHA or ESC/EAS goals resulted in simulated RRRs of 14% (7–25%) and 22% (15–32%), respectively, and ARRs of 4% (2–7%) and 6% (4–9%), respectively. Conclusion: In ASCVD patients, achieving ESC/EAS LDL-C goals could result in a 2% additional ARR over 10 years versus the ACC/AHA approach. Graphical abstract: [Figure not available: see fulltext.]

Published
2023

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