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Introduction: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems., Methods: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal)., Results: We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased ( p  < 0.00001). Women were more prone than men to develop long-term symptoms, and invasive mechanical ventilation also increased the frequency of symptoms at 30 days post-discharge., Conclusion: Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19., Competing Interests: Conflict of interest statement: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The Carlos Slim Foundation funded this study. The funding source was involved in the design of the study, analysis, interpretation of data, and in writing the manuscript. R.R.V.V., E.X.R.C., C.A.R.V., M.L.R.C., S.A.F., M.S.F., H.H.B., L.M.C., M.A.A., J.A.H.C., N.A.M., L.F.C., L.R.G.C., and A.J.F. are employees of the Temporary COVID-19 Hospital. J.L.G., L.M.J., L.A.M.J., D-A.A-H., H.G-R., and R.T-C. are employees of The Carlos Slim Foundation. All authors confirm that they had full access to all the study data and accept responsibility to submit for publication., (© The Author(s), 2022.)