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2. Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial.

Author

Oliver‐Pons, Carla, Sala‐Vila, Aleix, Cofán, Montserrat, Serra‐Mir, Mercè, Roth, Irene, Valls‐Pedret, Cinta, Domènech, Mònica, Ortega, Emilio, Rajaram, Sujatha, Sabaté, Joan, Ros, Emilio, and Chiva‐Blanch, Gemma

Subjects
WALNUT, PHOTON absorptiometry, OSTEOPENIA, FOOD consumption, BONE density, RESEARCH funding, STATISTICAL sampling, RANDOMIZED controlled trials, QUALITY assurance, OSTEOPOROSIS, TIME, BIOMARKERS, BONE remodeling, DIET, OLD age
Abstract

Background: Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha‐linolenic (the vegetable n‐3 fatty acid) and polyphenols, their regular consumption might be a dietary option to reduce age‐related bone loss. We determined whether daily walnut consumption improves bone mineral density (BMD) and circulating biomarkers of bone turnover. Methods: The Walnuts and Healthy Aging study (WAHA) is a two‐center, parallel, randomized controlled trial evaluating the effect of a diet enriched with walnuts at ≈15% energy compared with a control diet for 2 years on age‐related health outcomes in healthy men and women aged 63–79 years. Changes in BMD were a prespecified secondary outcome only at the Barcelona node of the trial, where 352 participants were randomized. Retention rate was 92.6%. Primary endpoints were 2‐year changes in BMD at the spine and the nondominant femoral neck, determined by dual‐energy X‐ray absorptiometry (DXA). Secondary endpoints were 2‐year changes in bone turnover biomarkers (adrenocorticotropic hormone, Dickkopf WNT signaling pathway inhibitor‐1, osteoprotegerin, osteocalcin, osteopontin, sclerostin, parathyroid hormone, and fibroblast growth factor‐23), which were quantified in 211 randomly selected participants. Results: The walnut diet versus the control diet had no effect on 2‐year changes in BMD at the spine (0.15% vs. 0.35%, p = 0.632) and femoral neck (−0.90% vs. −0.70%, p = 0.653), or on bone turnover biomarkers. Results were similar in participants treated or not with bone resorption inhibitors or those with or without osteoporosis/osteopenia at inclusion. Conclusions: Compared with the usual diet, a diet enriched with walnuts at 15% of energy for 2 years failed to improve BMD or circulating markers of bone metabolism in healthy older people. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial

Author

Estruch, Ramon, Martínez-González, Miguel Angel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Chiva-Blanch, Gemma, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Buil-Cosiales, Pilar, Sorlí, José V, Muñoz, Miguel A, Basora-Gallisá, Josep, Lamuela-Raventós, Rosa María, Serra-Mir, Mercè, and Ros, Emilio

Published
2019
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6. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial

Author

Papadaki, Angeliki, Martínez‐González, Miguel Ángel, Alonso‐Gómez, Angel, Rekondo, Javier, Salas‐Salvadó, Jordi, Corella, Dolores, Ros, Emilio, Fitó, Montse, Estruch, Ramon, Lapetra, José, García‐Rodriguez, Antonio, Fiol, Miquel, Serra‐Majem, Lluís, Pintó, Xavier, Ruiz‐Canela, Miguel, Bulló, Monica, Serra‐Mir, Mercè, Sorlí, Jose V., and Arós, Fernando

Published
2017
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7. Interplay of Walnut Consumption, Changes in Circulating miRNAs and Reduction in LDL-Cholesterol in Elders

Author

Gil-Zamorano, Judit, primary, Cofán, Montserrat, additional, López de las Hazas, María-Carmen, additional, García-Blanco, Tatiana, additional, García-Ruiz, Almudena, additional, Doménech, Mónica, additional, Serra-Mir, Mercè, additional, Roth, Irene, additional, Valls-Pedret, Cinta, additional, Rajaram, Sujatha, additional, Sabaté, Joan, additional, Ros, Emilio, additional, Dávalos, Alberto, additional, and Sala-Vila, Aleix, additional

Published
2022
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8. Effects of Walnut Consumption for 2 Years on Lipoprotein Subclasses Among Healthy Elders

Author

Rajaram, Sujatha, primary, Cofán, Montserrat, additional, Sala-Vila, Aleix, additional, Haddad, Ella, additional, Serra-Mir, Mercè, additional, Bitok, Edward, additional, Roth, Irene, additional, Freitas-Simoes, Tania M., additional, Kaur, Amandeep, additional, Valls-Pedret, Cinta, additional, Doménech, Mónica, additional, Oda, Keiji, additional, Corella, Dolores, additional, Sabaté, Joan, additional, and Ros, Emilio, additional

Published
2021
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10. Fruit and Vegetable Consumption is Inversely Associated with Plasma Saturated Fatty Acids at Baseline in Predimed Plus Trial

Author

Domínguez‐López, Inés, primary, Marhuenda‐Muñoz, María, additional, Tresserra‐Rimbau, Anna, additional, Hernáez, Álvaro, additional, Moreno, Juan José, additional, Martínez‐González, Miguel Ángel, additional, Salas‐Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, José Alfredo, additional, Alonso‐Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López‐Miranda, José, additional, Bernal‐Lopez, M. Rosa, additional, Lapetra, José, additional, Serra‐Majem, J. Luís, additional, Bueno‐Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín‐Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado‐Rodríguez, Miguel, additional, Matía‐Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Serra‐Mir, Mercè, additional, Vázquez‐Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Sorli, Jose V., additional, Castañer, Olga, additional, Abete, Itziar, additional, Luna, Jessica Vaquero, additional, Carabaño‐Moral, Rosa, additional, Asencio, Alberto, additional, Prohens, Lara, additional, Garcia‐Rios, Antonio, additional, Casas, Rosa, additional, Gomez‐Perez, Ana Maria, additional, Santos‐Lozano, José Manuel, additional, Razquin, Cristina, additional, Martínez, María Ángeles, additional, Saiz, Carmen, additional, Robledo‐Pastor, Vanesa, additional, Zulet, María Angeles, additional, Salaverria, Itziar, additional, Eguaras, Sonia, additional, Babio, Nancy, additional, Malcampo, Mireia, additional, Ros, Emilio, additional, Estruch, Ramon, additional, López‐Sabater, M. Carmen, additional, and Lamuela‐Raventós, Rosa M., additional

Published
2021
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11. Fruit and Vegetable Consumption is Inversely Associated with Plasma Saturated Fatty Acids at Baseline in Predimed Plus Trial

Author

Medicina, Medikuntza, Domínguez-López, Inés, Marhuenda-Muñoz, María, Tresserra-Rimbau, Anna, Hernáez, Álvaro, Moreno, Juan José, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Bernal-Lopez, M. Rosa, Lapetra, José, Serra Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Serra-Mir, Mercè, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Sorli, Jose V., Castañer, Olga, Abete, Itziar, Vaquero Luna, Jessica, Carabaño-Moral, Rosa, Asencio, Alberto, Prohens, Lara, Garcia-Rios, Antonio, Casas, Rosa, Gomez-Perez, Ana Maria, Santos-Lozano, José Manuel, Razquin, Cristina, Martínez, María Ángeles, Saiz, Carmen, Robledo-Pastor, Vanesa, Zulet, María Angeles, Salaverria, Itziar, Eguaras, Sonia, Babio, Nancy, Malcampo, Mireia, Ros, Emilio, Estruch, Ramón, López-Sabater, M. Carmen, Lamuela-Raventós, Rosa M., Medicina, Medikuntza, Domínguez-López, Inés, Marhuenda-Muñoz, María, Tresserra-Rimbau, Anna, Hernáez, Álvaro, Moreno, Juan José, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Bernal-Lopez, M. Rosa, Lapetra, José, Serra Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Serra-Mir, Mercè, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Sorli, Jose V., Castañer, Olga, Abete, Itziar, Vaquero Luna, Jessica, Carabaño-Moral, Rosa, Asencio, Alberto, Prohens, Lara, Garcia-Rios, Antonio, Casas, Rosa, Gomez-Perez, Ana Maria, Santos-Lozano, José Manuel, Razquin, Cristina, Martínez, María Ángeles, Saiz, Carmen, Robledo-Pastor, Vanesa, Zulet, María Angeles, Salaverria, Itziar, Eguaras, Sonia, Babio, Nancy, Malcampo, Mireia, Ros, Emilio, Estruch, Ramón, López-Sabater, M. Carmen, and Lamuela-Raventós, Rosa M.

Abstract

Scope Plasma fatty acids (FAs) are associated with the development of cardiovascular diseases and metabolic syndrome. The aim of our study is to assess the relationship between fruit and vegetable (F&V) consumption and plasma FAs and their subtypes. Methods and Results Plasma FAs are assessed in a cross-sectional analysis of a subsample of 240 subjects from the PREDIMED-Plus study. Participants are categorized into four groups of fruit, vegetable, and fat intake according to the food frequency questionnaire. Plasma FA analysis is performed using gas chromatography. Associations between FAs and F&V consumption are adjusted for age, sex, physical activity, body mass index (BMI), total energy intake, and alcohol consumption. Plasma saturated FAs are lower in groups with high F&V consumption (-1.20 mg cL(-1) [95% CI: [-2.22, -0.18], p-value = 0.021), especially when fat intake is high (-1.74 mg cL(-1) [95% CI: [-3.41, -0.06], p-value = 0.042). Total FAs and n-6 polyunsaturated FAs tend to be lower in high consumers of F&V only in the high-fat intake groups. Conclusions F&V consumption is associated with lower plasma saturated FAs when fat intake is high. These findings suggest that F&V consumption may have different associations with plasma FAs depending on their subtype and on the extent of fat intake.

Published
2021

12. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma

Author

Marhuenda-Muñoz, María, primary, Rinaldi de Alvarenga, José Fernando, additional, Hernáez, Álvaro, additional, Tresserra-Rimbau, Anna, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Malcampo, Mireia, additional, Martínez, José Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, J. Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Serra-Mir, Mercè, additional, Vázquez-Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Sorlí, Jose V., additional, Zomeño, María Dolores, additional, Zulet, María Angeles, additional, Vaquero-Luna, Jessica, additional, Carabaño-Moral, Rosa, additional, Notario-Barandiaran, Leyre, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Gómez-Pérez, Ana M., additional, Santos-Lozano, José Manuel, additional, Buil-Cosiales, Pilar, additional, Basora, Josep, additional, Portolés, Olga, additional, Schröder, Helmut, additional, Abete, Itziar, additional, Salaverria-Lete, Itziar, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Fitó, Montse, additional, Martínez-Huélamo, Miriam, additional, and Lamuela-Raventós, Rosa M, additional

Published
2021
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13. One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects

Author

Fundación Ramón Areces, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), López de las Hazas, María-Carmen, Gil-Zamorano, Judit, Cofán, Montserrat, Mantilla-Escalante, Diana C., García-Ruiz, Almudena, del Pozo-Acebo, Lorena, Pastor, Óscar, Yáñez-Mó, María, Mazzeo, Carla, Serra-Mir, Mercè, Domenech, Monica, Valls-Pedret, Cinta, Rajaram, Sujatha, Sabaté, Joan, Ros, Emilio, Sala-Vila, Aleix, Dávalos, Alberto, Fundación Ramón Areces, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), López de las Hazas, María-Carmen, Gil-Zamorano, Judit, Cofán, Montserrat, Mantilla-Escalante, Diana C., García-Ruiz, Almudena, del Pozo-Acebo, Lorena, Pastor, Óscar, Yáñez-Mó, María, Mazzeo, Carla, Serra-Mir, Mercè, Domenech, Monica, Valls-Pedret, Cinta, Rajaram, Sujatha, Sabaté, Joan, Ros, Emilio, Sala-Vila, Aleix, and Dávalos, Alberto

Abstract

Purpose: Epidemiological studies and clinical trials support the association of nut consumption with a lower risk of prevalent non-communicable diseases, particularly cardiovascular disease. However, the molecular mechanisms underlying nut benefits remain to be fully described. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and play a pivotal role in health and disease. Exosomes are extracellular vesicles released from cells and mediate intercellular communication. Whether nut consumption modulates circulating miRNAs (c-miRNAs) transported in exosomes is poorly described. Methods: Cognitively healthy elderly subjects were randomized to either control (n = 110, abstaining from walnuts) or daily supplementation with walnuts (15% of their total energy, ≈30–60 g/day, n = 101) for 1-year. C-miRNAs were screened in exosomes isolated from 10 samples, before and after supplementation, and identified c-miRNA candidates were validated in the whole cohort. In addition, nanoparticle tracking analysis and lipidomics were assessed in pooled exosomes from the whole cohort. Results: Exosomal hsa-miR-32-5p and hsa-miR-29b-3p were consistently induced by walnut consumption. No major changes in exosomal lipids, nanoparticle concentration or size were found. Conclusion: Our results provide novel evidence that certain c-miRNAs transported in exosomes are modulated by walnut consumption. The extent to which this finding contributes to the benefits of walnuts deserves further research.

Published
2020

15. One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects

Author

López de las Hazas, María-Carmen, primary, Gil-Zamorano, Judit, additional, Cofán, Montserrat, additional, Mantilla-Escalante, Diana C., additional, Garcia-Ruiz, Almudena, additional, del Pozo-Acebo, Lorena, additional, Pastor, Oscar, additional, Yañez-Mo, María, additional, Mazzeo, Carla, additional, Serra-Mir, Mercè, additional, Doménech, Monica, additional, Valls-Pedret, Cinta, additional, Rajaram, Sujatha, additional, Sabaté, Joan, additional, Ros, Emilio, additional, Sala-Vila, Aleix, additional, and Dávalos, Alberto, additional

Published
2020
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16. Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial

Author

Sala-Vila, Aleix, primary, Valls-Pedret, Cinta, additional, Rajaram, Sujatha, additional, Coll-Padrós, Nina, additional, Cofán, Montserrat, additional, Serra-Mir, Mercè, additional, Pérez-Heras, Ana M, additional, Roth, Irene, additional, Freitas-Simoes, Tania M, additional, Doménech, Mónica, additional, Calvo, Carlos, additional, López-Illamola, Anna, additional, Bitok, Edward, additional, Buxton, Natalie K, additional, Huey, Lynnley, additional, Arechiga, Adam, additional, Oda, Keiji, additional, Lee, Grace J, additional, Corella, Dolores, additional, Vaqué-Alcázar, Lídia, additional, Sala-Llonch, Roser, additional, Bartrés-Faz, David, additional, Sabaté, Joan, additional, and Ros, Emilio, additional

Published
2020
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17. Effects of Supplementing the Usual Diet with a Daily Dose of Walnuts for Two Years on Metabolic Syndrome and Its Components in an Elderly Cohort

Author

Al Abdrabalnabi, Ahmed, primary, Rajaram, Sujatha, additional, Bitok, Edward, additional, Oda, Keiji, additional, Beeson, W. Lawrence, additional, Kaur, Amandeep, additional, Cofán, Montserrat, additional, Serra-Mir, Mercè, additional, Roth, Irene, additional, Ros, Emilio, additional, and Sabaté, Joan, additional

Published
2020
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18. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., Rekondo, Javier, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., and Rekondo, Javier

Abstract

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts., [Design]: We assessed 18,566 participants in the “Seguimiento Universidad de Navarra” (SUN) cohort followed-up during 188,891 person-years and 6790 participants in the “PREvencion con DIeta MEDiterránea” (PREDIMED) randomized trial representing 30,233 person-years of follow-up. DII scores were calculated in both cohorts from validated FFQs. Higher DII scores corresponded to more proinflammatory diets. A total of 230 and 302 deaths occurred in SUN and PREDIMED, respectively. In a random-effect meta-analysis we included 12 prospective studies (SUN, PREDIMED and 10 additional studies) that assessed the association between DII scores and all-cause mortality., [Results]: After adjusting for a wide array of potential confounders, the comparison between extreme quartiles of the DII showed a positive and significant association with all-cause mortality in both the SUN (hazard ratio [HR] = 1.85; 95% CI: 1.15, 2.98; P-trend = 0.004) and the PREDIMED cohort (HR = 1.42; 95% CI: 1.00, 2.02; P-trend = 0.009). In the meta-analysis of 12 cohorts, the DII was significantly associated with an increase of 23% in all-cause mortality (95% CI: 16%–32%, for the highest vs lowest category of DII)., [Conclusion]: Our results provide strong and consistent support for the hypothesis that a pro-inflammatory diet is associated with increased all-cause mortality. The SUN cohort and PREDIMED trial were registered at clinicaltrials.gov as NCT02669602 and at isrctn.com as ISRCTN35739639, respectively.

Published
2019

19. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Hojiblanca, Fundación Patrimonio Comunal Olivarero, California Walnut Commission, Borges, Morella Nuts, Estruch, Ramón, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Chiva-Blanch, Gemma, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Buil-Cosiales, Pilar, Muñoz, Miguel Ángel, Basora, Josep, Lamuela-Raventós, Rosa M., Serra-Mir, Mercè, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Hojiblanca, Fundación Patrimonio Comunal Olivarero, California Walnut Commission, Borges, Morella Nuts, Estruch, Ramón, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Chiva-Blanch, Gemma, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Buil-Cosiales, Pilar, Muñoz, Miguel Ángel, Basora, Josep, Lamuela-Raventós, Rosa M., and Serra-Mir, Mercè

Abstract

[Background] Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese., [Methods] PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. 7447 asymptomatic men (aged 55–80 years) and women (aged 60–80 years) who had type 2 diabetes or three or more cardiovascular risk factors were randomly assigned (1:1:1) with a computer-generated number sequence to one of three interventions: Mediterranean diet supplemented with extra-virgin olive oil (n=2543); Mediterranean diet supplemented with nuts (n=2454); or a control diet (advice to reduce dietary fat; n=2450). Energy restriction was not advised, nor was physical activity promoted. In 2016, we reported the 5 year changes in bodyweight and waist circumference, but because of a subsequently identified protocol deviation (including enrolment of household members without randomisation, assignment to a study group without randomisation of some participants at one of 11 study sites, and apparent inconsistent use of randomisation tables at another site; 866 [11·6%] participants were affected in total), we have withdrawn our previously published report and now report revised effect estimates based on reanalyses that do not rely exclusively on the assumption that all the participants were randomly assigned. In this analysis of the trial, we measured bodyweight and waist circumference at baseline and yearly for 5 years in the intention-to-treat population. The PREDIMED trial is registered with ISRCTN.com, number ISRCTN35739639., [Findings] After a median 4·8 years (IQR 2·8–5·8) of follow-up, participants in all three groups had marginally reduced bodyweight and increased waist circumference. After multivariable adjustment, including adjustment for propensity scores and use of robust variance estimators, the difference in 5 year changes in bodyweight in the Mediterranean diet with olive oil group was −0·410 kg (95% CI −0·830 to 0·010; p=0·056) and in the nut group was −0·016 kg (–0·453 to 0·421; p=0·942), compared with the control group. The adjusted difference in 5 year changes in waist circumference was −0·466 cm (–1·109 to 0·176; p=0·154) in the Mediterranean diet with olive oil group and −0·923 cm (–1·604 to −0·241; p=0·008) in the nut group, compared with the control group., [Interpretation] A long-term intervention with an unrestricted-calorie, high-vegetable-fat Mediterranean diet was associated with no significant difference in bodyweight and some evidence of less gain in central adiposity compared with a control diet. These results lend support to advice not restricting intake of healthy fats for bodyweight maintenance.

Published
2019

20. The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial

Author

Freitas-Simoes, Tania-Marisa, primary, Cofán, Montserrat, additional, Blasco, Maria A., additional, Soberón, Nora, additional, Foronda, Miguel, additional, Corella, Dolores, additional, Asensio, Eva M., additional, Serra-Mir, Mercè, additional, Roth, Irene, additional, Calvo, Carlos, additional, Valls-Pedret, Cinta, additional, Casaroli-Marano, Ricardo P., additional, Doménech, Mónica, additional, Rajaram, Sujatha, additional, Sabaté, Joan, additional, Ros, Emilio, additional, and Sala-Vila, Aleix, additional

Published
2019
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21. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. Eur J Heart Fail 2017; 19 :1179–1185. doi: 10.1002/ejhf.750

Author

Papadaki, Angeliki, primary, Martínez‐González, Miguel Ángel, additional, Alonso‐Gómez, Angel, additional, Rekondo, Javier, additional, Salas‐Salvadó, Jordi, additional, Corella, Dolores, additional, Ros, Emilio, additional, Fitó, Montse, additional, Estruch, Ramon, additional, Lapetra, José, additional, García‐Rodriguez, Antonio, additional, Fiol, Miquel, additional, Serra‐Majem, Lluís, additional, Pintó, Xavier, additional, Ruiz‐Canela, Miguel, additional, Bulló, Monica, additional, Serra‐Mir, Mercè, additional, Sorlí, Jose V., additional, and Arós, Fernando, additional

Published
2019
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22. Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial

Author

Freitas-Simoes, Tania-Marisa, primary, Cofán, Montserrat, additional, Blasco, Maria, additional, Soberón, Nora, additional, Foronda, Miguel, additional, Serra-Mir, Mercè, additional, Roth, Irene, additional, Valls-Pedret, Cinta, additional, Doménech, Mónica, additional, Ponferrada-Ariza, Elena, additional, Calvo, Carlos, additional, Rajaram, Sujatha, additional, Sabaté, Joan, additional, Ros, Emilio, additional, and Sala-Vila, Aleix, additional

Published
2018
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23. Retracted: Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial

Author

Estruch, Ramon, Martínez-González, Miguel Angel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Chiva-Blanch, Gemma, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Buil-Cosiales, Pilar, Sorlí, José V, Muñoz, Miguel A, Basora-Gallisá, Josep, Lamuela-Raventós, Rosa María, Serra-Mir, Mercè, and Ros, Emilio

Published
2016
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26. Prediction of Cardiovascular Disease by the Framingham‐REGICOR Equation in the High‐Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different Risk Strata

Author

Amor, Antonio J., primary, Serra‐Mir, Mercè, additional, Martínez‐González, Miguel A., additional, Corella, Dolores, additional, Salas‐Salvadó, Jordi, additional, Fitó, Montserrat, additional, Estruch, Ramón, additional, Serra‐Majem, Lluis, additional, Arós, Fernando, additional, Babio, Nancy, additional, Ros, Emilio, additional, Ortega, Emilio, additional, Pérez‐Heras, A., additional, Viñas, C., additional, Casas, R., additional, de Santamaría, L., additional, Romero, S., additional, Sacanella, E., additional, Chiva, G., additional, Valderas, P., additional, Arranz, S., additional, Baena, J. M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, Ll., additional, Parra, Ll., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M. T., additional, Martin, M. T., additional, Sánchez, M. S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Sala‐Vila, A., additional, Cofán, M., additional, Valls‐Pedret, C., additional, Freitas‐Simoes, T. M., additional, Doménech, M., additional, Gilabert, R., additional, Bargalló, N., additional, Bulló, M., additional, Basora, J., additional, González, R., additional, Díaz‐López, A., additional, Molina, C., additional, Mena, G., additional, Márquez, F., additional, Martínez, P., additional, Ibarrola, N., additional, Sorli, M., additional, García Roselló, J., additional, Martín, F., additional, Tort, N., additional, Isach, A., additional, Salas‐Huetos, A., additional, Becerra‐Tomás, N., additional, Rosique Esteban, N., additional, Cabré, J. J., additional, Mestres, G., additional, Paris, F., additional, Llaurado, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Hernandez‐Alonso, P., additional, Giardina, S., additional, Ferreira‐Pego, C., additional, Papandreou, C., additional, Camacho, L., additional, Toledo, E., additional, Buil‐Cosiales, P., additional, Ruiz‐Canela, M., additional, Martínez, J. A., additional, Sanjulian, B., additional, Sánchez‐Tainta, A., additional, Diez‐Espino, J., additional, Razquin, C., additional, Garcia‐Arellano, A., additional, Goni, E., additional, Vazquez, Z., additional, Berrade, N., additional, Extremera‐Urabayen, V., additional, Eguaras, S., additional, Marti, A., additional, Arroyo‐Azpa, C., additional, García‐Pérez, L., additional, Villanueva Telleria, J., additional, Cortés Ugalde, F., additional, Sagredo Arce, T., additional, de la Noceda Montoy, M. D. García, additional, Vigata López, M. D., additional, Arceiz Campo, M. T., additional, Urtasun Samper, A., additional, Gueto Rubio, M. V., additional, Sola, A., additional, Goñi, N., additional, Lecea, O., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz‐Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Castañer, O., additional, Rovira, A., additional, Farre, M., additional, Sorli, J. V., additional, Zanon‐Moreno, V., additional, Carrasco, P., additional, Ortega‐Azorín, C., additional, Asensio, E. M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J. I., additional, Saiz, C., additional, Portolés, O., additional, Giménez, F. J., additional, Coltell, O., additional, Guillem‐Saiz, P., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M. A., additional, Godoy, D., additional, Carratala‐Calvo, A., additional, Martín‐Rillo, M. J., additional, Llopis‐Osorio, E., additional, Ruiz‐Baixauli, J., additional, Bertolín‐Muñoz, A., additional, Salaverría, I., additional, del Hierro, T., additional, Algorta, J., additional, Francisco, S., additional, Alonso‐Gómez, A., additional, Sanz, E., additional, Rekondo, J., additional, Bello, M. C., additional, Loma‐Osorio, A., additional, Gómez‐Gracia, E., additional, Warnberg, J., additional, Benítez Pont, R., additional, Bianchi Alba, M., additional, Gómez‐Huelgas, R., additional, Martínez‐González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J. J., additional, Vargas López, E., additional, Ruiz‐Gutiérrez, V., additional, Sánchez Perona, J., additional, Montero Romero, E., additional, García‐García, M., additional, Jurado‐Ruiz, E., additional, Fiol, M., additional, García‐Valdueza, M., additional, Moñino, M., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Ginard, M., additional, Fiol, F., additional, Jover, A., additional, Romaguera, D., additional, García, J., additional, Lapetra, J., additional, Santos‐Lozano, J. M., additional, Ortega‐Calvo, M., additional, Mellado, L., additional, Leal, M., additional, Martínez, E., additional, José García, F., additional, Román, P., additional, Iglesias, P., additional, Corchado, Y., additional, Miró, L., additional, Domínguez, C., additional, Lozano, J. M., additional, Mayoral, E., additional, Lamuela‐Raventós, R. M., additional, López‐Sabater, M. C., additional, Castellote‐Bargallo, A. I., additional, Tresserra‐Rimbau, A., additional, Álvarez‐Pérez, J., additional, Díaz‐Benítez, E. M., additional, Bautista Castaño, I., additional, Sánchez‐Villegas, A., additional, Fernández‐Rodríguez, M. J., additional, Casanas Quintana, T., additional, Pérez‐Cabrera, J., additional, Nissensohn, M., additional, Díaz‐González, V., additional, Ruano‐Rodríguez, C., additional, Ortiz‐Andrelluchi, A. P., additional, Macías Gutiérrez, B., additional, Santana‐Santana, A. J., additional, Pintó, X., additional, de la Cruz, E., additional, Galera, A., additional, Soler, Y., additional, Trias, F., additional, Sarasa, I., additional, Padres, E., additional, Corbella, E., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M. A., additional, García, L., additional, Flores, G., additional, Verdú, J. M., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M. C., additional, Guarner, A., additional, Santamaría, M. I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Tur, J. A., additional, Portillo, M. P., additional, Sáez, G., additional, Aldamiz, M., additional, Alonso, A., additional, Berjón, J., additional, Forga, L., additional, Gallego, J., additional, Larrauri, A., additional, Portu, J., additional, Timiraos, J., additional, and Serrano‐Martínez, M., additional

Published
2017
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27. The Walnuts and Healthy Aging Study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging

Author

Rajaram, Sujatha, primary, Valls-Pedret, Cinta, additional, Cofán, Montserrat, additional, Sabaté, Joan, additional, Serra-Mir, Mercè, additional, Pérez-Heras, Ana M., additional, Arechiga, Adam, additional, Casaroli-Marano, Ricardo P., additional, Alforja, Socorro, additional, Sala-Vila, Aleix, additional, Doménech, Mónica, additional, Roth, Irene, additional, Freitas-Simoes, Tania M., additional, Calvo, Carlos, additional, López-Illamola, Anna, additional, Haddad, Ella, additional, Bitok, Edward, additional, Kazzi, Natalie, additional, Huey, Lynnley, additional, Fan, Joseph, additional, and Ros, Emilio, additional

Published
2017
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28. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. Eur J Heart Fail 2017;19:1179-1185. doi: 10.1002/ejhf.750.

Author

Papadaki, Angeliki, Martínez‐González, Miguel Ángel, Alonso‐Gómez, Angel, Rekondo, Javier, Salas‐Salvadó, Jordi, Corella, Dolores, Ros, Emilio, Fitó, Montse, Estruch, Ramon, Lapetra, José, García‐Rodriguez, Antonio, Fiol, Miquel, Serra‐Majem, Lluís, Pintó, Xavier, Ruiz‐Canela, Miguel, Bulló, Monica, Serra‐Mir, Mercè, Sorlí, Jose V., Arós, Fernando, and Martínez-González, Miguel Ángel

Subjects
HEART failure, MEDITERRANEAN diet, HEART
Published
2019
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29. Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study.

Author

Sala ‐ Vila, Aleix, Guasch ‐ Ferré, Marta, Hu, Frank B., Sánchez ‐ Tainta, Ana, Bulló, Mònica, Serra ‐ Mir, Mercè, López ‐ Sabater, Carmen, Sorlí, Jose V., Arós, Fernando, Fiol, Miquel, Muñoz, Miguel A., Serra ‐ Majem, Luis, Martínez, J. Alfredo, Corella, Dolores, Fitó, Montserrat, Salas ‐ Salvadó, Jordi, Martínez ‐ González, Miguel A., Estruch, Ramón, Ros, Emilio, and Pérez ‐ Heras, A.

Published
2016
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30. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial

Author

Estruch, Ramon, Martínez-González, Miguel Angel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Chiva-Blanch, Gemma, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Buil-Cosiales, Pilar, Sorlí, José V, Muñoz, Miguel A, Basora-Gallisá, Josep, Lamuela-Raventós, Rosa María, Serra-Mir, Mercè, and Ros, Emilio

Abstract

Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.

Published
2016
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31. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial

Author

Papadaki, Angeliki, Martínez-González, Miguel Ángel, 1957, Alonso Gómez, Ángel M., Rekondo, Javier, Salas Salvadó, Jordi, Corella Piquer, Dolores, Ros Rahola, Emilio, Fitó Colomer, Montserrat, Estruch Riba, Ramon, Lapetra, José, García Rodriguez, Antonio, Fiol Sala, Miguel, Serra Majem, Lluís, Pintó Sala, Xavier, Ruiz-Canela, Miguel, Bulló, Mònica, Serra-Mir, Mercè, Sorlí, José V., Arós, Fernando, and Universitat de Barcelona

Subjects
Male, AF, atrial fibrillation, Heart diseases, BMI, body mass index, Statistics as Topic, HDL, high-density lipoprotein, Heart failure, T2D, type 2 diabetes, CVD, cardiovascular disease, Diet, Mediterranean, CHD, coronary heart disease, Risk Assessment, HF, heart failure, Malalties del cor, Mediterranean cooking, PAD, peripheral arterial disease, Mediterranean diet, LDL, low-density lipoprotein, Cuina mediterrània, Humans, Nuts, FFQ, food frequency questionnaire, PREDIMED, Prevención con Dieta Mediterránea, Olive Oil, Dieta -- Mediterrània, Regió de la, Aged, Heart Failure, EVOO, extra virgin olive oil, Incidence, WtHR, waist-to-height ratio, PREDIMED study, Middle Aged, Cardiovascular disease, Cardiac arrest, Aturada cardíaca, MedDiet, Mediterranean diet, Infart de miocardi, Outcome and Process Assessment, Health Care, Cardiovascular Diseases, Dietary Supplements, MI, myocardial infarction, Female
Abstract

Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.

32. Effects of Long-Term Walnut Supplementation on Body Weight in Free-Living Elderly: Results of a Randomized Controlled Trial.

Author

Rajaram, Sujatha, Jaceldo-Siegl, Karen, Oda, Keiji, Sabaté, Joan, Bitok, Edward, Serra-Mir, Mercè, Sala-Vila, Aleix, and Ros, Emilio

Abstract

Objective: To assess the effects of chronic walnut consumption on body weight and adiposity in elderly individuals. Methods: The Walnuts and Healthy Aging study is a dual-center (Barcelona, Spain and Loma Linda University (LLU)), 2-year randomized parallel trial. This report concerns only the LLU cohort. Healthy elders (mean age 69 year, 67% women) were randomly assigned to walnut (n = 183) or control diets (n = 173). Subjects in the walnut group received packaged walnuts (28–56 g/day), equivalent to ≈15% of daily energy requirements, to incorporate into their habitual diet, while those in the control group abstained from walnuts. Adiposity was measured periodically, and data were adjusted for in-trial changes in self-reported physical activity. Results: After 2 years, body weight significantly decreased (p = 0.031), while body fat significantly increased (p = 0.0001). However, no significant differences were observed between the control and walnut groups regarding body weight (−0.6 kg and −0.4 kg, respectively, p = 0.67) or body fat (+0.9% and +1.3%, respectively, p = 0.53). Lean body mass, waist circumference, and waist-to-hip ratio remained essentially unchanged. Sensitivity analyses were consistent with the findings of primary analysis. Conclusion: Our findings indicate that walnuts can be incorporated into the daily diet of healthy elders without concern for adverse effects on body weight or body composition. [ABSTRACT FROM AUTHOR]

Published
2018
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