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389 results on '"Seron, D."'

2. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

Author

Loupy, A, Haas, M, Solez, K, Racusen, L, Glotz, D, Seron, D, Nankivell, BJ, Colvin, RB, Afrouzian, M, Akalin, E, Alachkar, N, Bagnasco, S, Becker, JU, Cornell, L, Drachenberg, C, Dragun, D, de Kort, H, Gibson, IW, Kraus, ES, Lefaucheur, C, Legendre, C, Liapis, H, Muthukumar, T, Nickeleit, V, Orandi, B, Park, W, Rabant, M, Randhawa, P, Reed, EF, Roufosse, C, Seshan, SV, Sis, B, Singh, HK, Schinstock, C, Tambur, A, Zeevi, A, and Mengel, M

Subjects
Organ Transplantation, Clinical Research, Transplantation, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Renal and urogenital, Arteritis, Complement C4b, Graft Rejection, Humans, Isoantibodies, Kidney Transplantation, Peptide Fragments, Research Report, clinical research, practice, translational research, science, kidney transplantation, nephrology, pathology, histopathology, organ transplantation in general, rejection, rejection: antibody-mediated, rejection: subclinical, rejection: T cell mediated, clinical research/practice, kidney transplantation/nephrology, pathology/histopathology, translational research/science, Medical and Health Sciences, Surgery
Abstract

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i-IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell-mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus-based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next-generation clinical trials.

Published
2017

5. Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

Author

Rebollo-Mesa, I., Nova-Lamperti, E., Mobillo, P., Runglall, M., Christakoudi, S., Norris, S., Smallcombe, N., Kamra, Y., Hilton, R., Bhandari, S., Baker, R., Berglund, D., Carr, S., Game, D., Griffin, S., Kalra, P.A., Lewis, R., Mark, P.B., Marks, S., Macphee, I., McKane, W., Mohaupt, M.G., Pararajasingam, R., Kon, S.P., Serón, D., Sinha, M.D., Tucker, B., Viklický, O., Lechler, R.I., Lord, G.M., and Hernandez-Fuentes, M.P.

Published
2016
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7. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell–mediated rejection, antibody‐mediated rejection, and prospects for integrative endpoints for next‐generation clinical trials

Author

Haas, M., Loupy, A., Lefaucheur, C., Roufosse, C., Glotz, D., Seron, D., Nankivell, B. J., Halloran, P. F., Colvin, R. B., Akalin, Enver, Alachkar, N., Bagnasco, S., Bouatou, Y., Becker, J. U., Cornell, L. D., van Huyen, J. P. Duong, Gibson, I. W., Kraus, Edward S., Mannon, R. B., Naesens, M., Nickeleit, V., Nickerson, P., Segev, D. L., Singh, H. K., Stegall, M., Randhawa, P., Racusen, L., Solez, K., and Mengel, M.

Published
2018
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16. Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions

Author

Solez, K., Colvin, R.B., Racusen, L.C., Haas, M., Sis, B., Mengel, M., Halloran, P.F., Baldwin, W., Banfi, G., Collins, A.B., Cosio, F., David, D.S.R., Drachenberg, C., Einecke, G., Fogo, A.B., Gibson, I.W., Glotz, D., Iskandar, S.S., Kraus, E., Lerut, E., Mannon, R.B., Mihatsch, M., Nankivell, B.J., Nickeleit, V., Papadimitriou, J.C., Randhawa, P., Regele, H., Renaudin, K., Roberts, I., Seron, D., Smith, R.N., and Valente, M.

Published
2008
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21. Reduced nonlinear microwave effects in YBaCuO resonators on a polarized SrTi[O.sub.3] thin layer

Author

Seron, D., Guyard, S., Bouzehouane, K., Lemaitre, Y., Marcilhac, B., and Mage, J.-C.

Subjects
Barium compounds -- Electric properties, Barium compounds -- Structure, Barium compounds -- Thermal properties, Copper oxide superconductors -- Electric properties, Copper oxide superconductors -- Thermal properties, High temperature superconductors -- Electric properties, Yttrium -- Electric properties, Yttrium -- Thermal properties, Business, Electronics, Electronics and electrical industries
Published
2009

33. Banff ʼ09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups

Author

Sis, B., Mengel, M., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Baldwin, W. M., III, Bracamonte, E. R., Broecker, V., Cosio, F., Demetris, A. J., Drachenberg, C., Einecke, G., Gloor, J., Glotz, D., Kraus, E., Legendre, C., Liapis, H., Mannon, R. B., Nankivell, B. J., Nickeleit, V., Papadimitriou, J. C., Randhawa, P., Regele, H., Renaudin, K., Rodriguez, E. R., Seron, D., Seshan, S., Suthanthiran, M., Wasowska, B. A., Zachary, A., and Zeevi, A.

Published
2010
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37. Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Author

Valls, J, Cambray, S, Perez-Guallar, C, Bozic, M, Bermudez-Lopez, M, Fernandez, E, Betriu, A, Rodriguez, I, Valdivielso, JM, Regidor, MJA, Almirall, J, Ponz, E, Coloma, JA, Rubio, MAB, Diaz, RR, Rodriguez, MB, Gascon, A, Sanjuan, JB, Artero, JB, Romero, JBC, Cases, SM, Varela, JC, Acevedo, PC, Bassa, JC, Amenos, AC, Jimenez, EM, Lopez, RM, Guldris, SC, Prieto, SL, Mongay, LC, Comerma, I, Jove, MTC, Izquierdo, MC, de Alvaro, F, Ojanguren, CH, de la Fuente, GD, Pino, MDDY, Izquierdo, RDT, Hormigos, FA, Dotori, M, Duarte, V, Torres, SE, Reyes, MJF, Rodriguez, MLF, Fernandez, G, Serrano, AG, Canton, CG, Herrera, ALG, Mena, MG, Sacaluga, LG, Aguilar, M, Gorriz, JL, Loza, EH, Lerma, JL, Canada, AL, Alvarez, JPM, Alemany, NM, Garcia, JM, Castelao, AM, Villaescusa, MM, Martinez, I, Eguren, IM, Los Huertos, SM, Mirco, RM, Vila, AM, Diaz, ABM, Gonzalez, JFN, Nieto, J, Carreno, A, Fernandez, EN, Ortiz, A, Fernandez, B, Paraiso, V, Fontan, MP, Domingo, AP, Haces, CP, Garrido, MDP, Velasco, MP, Mari, CP, Gorrin, MR, Rubio, E, Ruiz, P, Lazo, MS, Puerto, AIM, Tomero, JAS, Sanchez, JE, Lorman, RS, Saracho, R, Sarrias, M, Seron, D, Soler, MJ, Barrios, C, Sousa, F, Toran, D, Molina, FT, Carrasco, JJU, Cortes, IV, del Perugia, MMV, Ruiz, RCV, Altozano, CS, Rodenas, MA, Gil, IG, Gil, FA, Criado, EG, Belinchon, RD, Toro, JMF, and Garrote, JAD

Subjects
haplotype, single nucleotide polymorphism, genetic association study, risk factors, chronic kidney disease, linkage disequilibrium
Abstract

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2,445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD.

Published
2019

39. Banff ʼ05 Meeting Report: Differential Diagnosis of Chronic Allograft Injury and Elimination of Chronic Allograft Nephropathy (‘CAN’)

Author

Solez, K., Colvin, R. B., Racusen, L. C., Sis, B., Halloran, P. F., Birk, P. E., Campbell, P. M., Cascalho, M., Collins, A. B., Demetris, A. J., Drachenberg, C. B., Gibson, I. W., Grimm, P. C., Haas, M., Lerut, E., Liapis, H., Mannon, R. B., Marcus, P. B., Mengel, M., Mihatsch, M. J., Nankivell, B. J., Nickeleit, V., Papadimitriou, J. C., Platt, J. L., Randhawa, P., Roberts, I., Salinas-Madriga, L., Salomon, D. R., Seron, D., Sheaff, M., and Weening, J. J.

Published
2007

40. Phenomenology World-Wide

Author

Bello, A. Ales, primary, Antonelli, M., additional, Backhaus, G., additional, Balaban, O., additional, Baptist, G., additional, Bengtsson, J., additional, Benoist, J., additional, Bernasconi, R., additional, Bielawka, M., additional, Bosio, G., additional, Bourgeois, P., additional, Buceniece, E., additional, Callieri, B., additional, Cantista, M. J., additional, Canán, A. Carrillo, additional, Cecilia, M. A., additional, Conill, J., additional, Cousin, F. R., additional, d’Ippolito, B. M., additional, de Monticelli, R., additional, Di Pinto, L., additional, Dolidze, M. G., additional, Domagala, E., additional, Duncan, R., additional, Eng, E., additional, Flores, L., additional, Frings, M. S., additional, Garrabé, J., additional, Giovannangeli, D., additional, Golomb, J., additional, Grillo, E., additional, Hanafi, H., additional, Haney, K., additional, Heelan, P. A., additional, Teba, M. Illán, additional, Jervolino, D., additional, Kocay, V., additional, Kühn, R., additional, Levering, B., additional, Luft, S., additional, Flores, H. Luis, additional, Majewska, Z., additional, Manganaro, P., additional, Martins, M. M., additional, Mazzú, A., additional, Miles, J., additional, Mróz, P., additional, Hill, C. Ortiz, additional, Park, Y., additional, Raynova, Y. B., additional, Sindoni, P. Ricci, additional, Rinofner-Kreidl, S., additional, Rokstad, K., additional, Rossi, O., additional, Ryba, T., additional, Schmitz, H., additional, Scott, C. E., additional, Seron, D., additional, Sinha, D., additional, Sivák, J., additional, Staudigl, M., additional, Sugarman, R., additional, Surzyn, J., additional, Sweeney, R. D., additional, Syřišt’ová, E., additional, Tymieniecka, Anna-Teresa, additional, Vandenberg, D., additional, van Manen, M., additional, Verducci, D., additional, Warmínski, A., additional, Watanabe, J., additional, Wise, R. J., additional, and Zecchi, S., additional

Published
2002
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50. High-frequency characterization and modeling of paraelectric/superconductor resonators for high power-handling microwave passive devices.

Author

Seron, D., Guyard, S., Bouzehouane, K., Lemaitre, Y., Marcilhac, B., and Mage, J. C.

Subjects
*MICROWAVE devices, *PERMITTIVITY, *THIN films, *HIGH temperature superconductors, *SUPERCONDUCTORS
Abstract

The theoretical conditions required to observe reduced nonlinearities in passive microwave devices made of a paraelectric (PE) thin layer and a high-temperature superconductor (HTS) thin film are presented. In a transmission line (TL) combining both materials, the nonlinear permittivity [variant_greek_epsilon]r(Vrf) of the PE generates a nonlinear capacitive contribution Cd(Vrf), whereas the nonlinear penetration depth λ(Irf) of the HTS produces a nonlinear inductive contribution Ld(Irf). These contributions act in opposite ways. Under determined conditions that will be defined, they may fully compensate or at least lead to the reduction of the spurious signal level. The HTS nonlinearities may be lowered by employing very thin layers of PE. In this case, the high dielectric loss tangent (tan δ) of PE should not be such an issue. Based on experimental results obtained with superconducting YBa2Cu3O7-δ resonators integrating different thicknesses of paraelectric SrTiO3 (STO) deposited on LaAlO3 substrates, the loss level could then be considered in the simulation of the proposed compensation effect. The results show that the reduction of the unloaded quality factor (Q0) as the thickness of STO increases also impacts the level of spurious signals. Then, an analytic expression for the Q0 of a resonant TL that integrates a PE and a HTS thin layer is proposed. It specifies the conditions for reducing the total nonlinear response. These results could then be applied to realize high power handling HTS passive microwave devices. [ABSTRACT FROM AUTHOR]

Published
2007
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