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2 results on '"Sergio Lacayo"'

1. 1342 Therapeutic targeting of MARCO with PY265 antibody promotes myeloid cell reprogramming and unleashes anti-tumor immunity

Author

Linnea Haeggblom, Subhadra Dash, Yelena Vayn, Josh Rudolph, Rachael Palmer, Xi Yang, Sergio Lacayo, Cesar Juarez, Erin Mayes, Rachel Greathouse, Kara Mojica, Carlos Santamaria, Johanna Ramoth, Ranna Mehta, Maryam Yousefi, Nadine Jahchan, Svetlana Gratch, Amy-Jo Casbon, Joshua Pollack, Marc Chamberlain, Leonard Reyno, Matthew Myers, Vladislava Juric, Linda Liang, Kristen Pierce, and Kevin Baker

Published
2022
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2. Preclinical Evaluation of an Anti-Nectin-4 ImmunoPET Reagent in Tumor-Bearing Mice and Biodistribution Studies in Cynomolgus Monkeys

Author

Sosuke Miyoshi, Akihiro Noda, Hiroshi Fushiki, Alla Verlinsky, Peng Yang, Yoshihiro Murakami, Sergio Lacayo, Dean O Campbell, Edward Cabral, David R. Stover, Ingrid B.J.K. Joseph, Yuji Fujita, and Josh Snyder

Subjects
0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Biodistribution, Metastatic lesions, Bone disease, medicine.drug_class, Nectins, Bone Neoplasms, Positive correlation, Monoclonal antibody, 03 medical and health sciences, Mice, 0302 clinical medicine, Breast cancer, Nectin, Cell Line, Tumor, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Tissue Distribution, business.industry, Liver Neoplasms, Antibodies, Monoclonal, medicine.disease, Immunohistochemistry, Xenograft Model Antitumor Assays, Macaca fascicularis, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Reagent, Positron-Emission Tomography, Indicators and Reagents, Zirconium, business, Cell Adhesion Molecules
Abstract

Nectin-4 is selectively overexpressed in a variety of cancers and is currently under clinical investigation as a therapeutic target. A monoclonal antibody against nectin-4 (AGS-22M6) was evaluated as an Immuno-positron emission tomography (ImmunoPET) reagent. Its ability to assay nectin-4 expression as well as detect nectin-4 positive tumors in the liver and bone was evaluated using mouse models.The biodistribution of [(89)Zr]AGS-22M6 was evaluated in mice bearing tumors with varying levels of nectin-4 expression. An isogenic breast cancer tumor line was used to model metastatic liver and bone disease in mice. The biodistribution of [(18)F]AGS-22M6 in cynomolgus monkeys was evaluated.A positive correlation was demonstrated between tumor nectin-4 expression and [(89)Zr]AGS-22M6 uptake. Tumors in the liver and bone were detected and differentiated based on nectin-4 expression. [(18)F]AGS-22M6 showed limited uptake in cynomolgus monkey tissues.[(89)Zr]AGS-22M6 is a promising ImmunoPET reagent that can assay nectin-4 expression in both primary and metastatic lesions.

Published
2016

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