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1. COVID-19 vaccination, acceptance, safety, and side-effects in European patients with severe asthma

Author

Bossios, Apostolos, primary, Bacon, Alison M., additional, Eger, Katrien, additional, Paróczai, Dóra, additional, Schleich, Florence, additional, Hanon, Shane, additional, Sergejeva, Svetlana, additional, Zervas, Eleftherios, additional, Katsoulis, Konstantinos, additional, Aggelopoulou, Christina, additional, Kostikas, Konstantinos, additional, Gaki, Eleni, additional, Rovina, Nikoletta, additional, Csoma, Zsuzsanna, additional, Grisle, Ineta, additional, Bieksiené, Kristina, additional, Palacionyte, Jolita, additional, ten Brinke, Anneke, additional, Hashimoto, Simone, additional, Mihălţan, Florin, additional, Nenasheva, Natalia, additional, Zvezdin, Biljana, additional, Čekerevac, Ivan, additional, Hromiš, Sanja, additional, Ćupurdija, Vojislav, additional, Lazic, Zorica, additional, Chaudhuri, Rekha, additional, Smith, Steven James, additional, Rupani, Hitasha, additional, Haitchi, Hans Michael, additional, Kurukulaaratchy, Ramesh, additional, Fulton, Olivia, additional, Frankemölle, Betty, additional, Howarth, Peter, additional, Porsbjerg, Celeste, additional, Bel, Elisabeth H., additional, Djukanovic, Ratko, additional, and Hyland, Michael E., additional

Published
2023
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2. Heterogeneity in the use of biologics for severe asthma in Europe: a SHARP ERS study

Author

Frix, Anne-Noelle, primary, Heaney, Liam G., additional, Dahlén, Barbro, additional, Mihaltan, Florin, additional, Sergejeva, Svetlana, additional, Popović-Grle, Sanja, additional, Sedlak, Vratislav, additional, Lehtimäki, Lauri, additional, Bourdin, Arnaud, additional, Korn, Stephanie, additional, Zervas, Eleftherios, additional, Csoma, Zsuzsanna, additional, Lúðvíksdóttir, Dora, additional, Butler, Marcus, additional, Canonica, Giorgio Walter, additional, Grisle, Ineta, additional, Bieksiene, Kristina, additional, Ten Brinke, Anneke, additional, Kuna, Piotr, additional, Chaves Loureiro, Claudia, additional, Nenasheva, Natalia M., additional, Lazic, Zorica, additional, Škrgat, Sabina, additional, Ramos-Barbon, David, additional, Leuppi, Joerg, additional, Gemicioglu, Bilun, additional, Bossios, Apostolos, additional, Porsbjerg, Celeste M., additional, Bel, Elisabeth H., additional, Djukanovic, Ratko, additional, and Louis, Renaud, additional

Published
2022
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3. The effect of the COVID-19 pandemic on severe asthma care in Europe : will care change for good?

Author

Eger, Katrien, Paroczai, Dora, Bacon, Alison, Schleich, Florence, Sergejeva, Svetlana, Bourdin, Arnaud, Vachier, Isabelle, Zervas, Eleftherios, Katsoulis, Konstantinos, Papapetrou, Dimosthenis, Kostikas, Konstantinos, Csoma, Zsuzsanna, Heffler, Enrico, Canonica, Giorgio Walter, Grisle, Ineta, Bieksiene, Kristina, Palacionyte, Jolita, Ten Brinke, Anneke, Hashimoto, Simone, Smeenk, Frank W. J. M., Braunstahl, Gert-Jan, van der Sar, Simone, Mihaltan, Florin, Nenasheva, Natalia, Peredelskaya, Marina, Zvezdin, Biljana, Cekerevac, Ivan, Hromis, Sanja, Cupurdija, Vojislav, Lazic, Zorica, Milenkovic, Branislava, Dimic-Janjic, Sanja, Yasinska, Valentyna, Dahlen, Barbro, Bossios, Apostolos, Lazarinis, Nikolaos, Aronsson, David, Egesten, Arne, Munir, Abul Kashem Mohammad, Ahlbeck, Lars, Janson, Christer, Skrgat, Sabina, Edelbaher, Natalija, Leuppi, Joerg, Jaun, Fabienne, Rudiger, Jochen, Pavlov, Nikolay, Gianella, Pietro, Fischer, Reta, Charbonnier, Florian, Chaudhuri, Rekha, Smith, Steven James, Doe, Simon, Fawdon, Michelle, Masoli, Matthew, Heaney, Liam, Haitchi, Hans Michael, Kurukulaaratchy, Ramesh, Fulton, Olivia, Frankemolle, Betty, Gibson, Toni, Needham, Karen, Howarth, Peter, Djukanovic, Ratko, Bel, Elisabeth, Hyland, Michael, Eger, Katrien, Paroczai, Dora, Bacon, Alison, Schleich, Florence, Sergejeva, Svetlana, Bourdin, Arnaud, Vachier, Isabelle, Zervas, Eleftherios, Katsoulis, Konstantinos, Papapetrou, Dimosthenis, Kostikas, Konstantinos, Csoma, Zsuzsanna, Heffler, Enrico, Canonica, Giorgio Walter, Grisle, Ineta, Bieksiene, Kristina, Palacionyte, Jolita, Ten Brinke, Anneke, Hashimoto, Simone, Smeenk, Frank W. J. M., Braunstahl, Gert-Jan, van der Sar, Simone, Mihaltan, Florin, Nenasheva, Natalia, Peredelskaya, Marina, Zvezdin, Biljana, Cekerevac, Ivan, Hromis, Sanja, Cupurdija, Vojislav, Lazic, Zorica, Milenkovic, Branislava, Dimic-Janjic, Sanja, Yasinska, Valentyna, Dahlen, Barbro, Bossios, Apostolos, Lazarinis, Nikolaos, Aronsson, David, Egesten, Arne, Munir, Abul Kashem Mohammad, Ahlbeck, Lars, Janson, Christer, Skrgat, Sabina, Edelbaher, Natalija, Leuppi, Joerg, Jaun, Fabienne, Rudiger, Jochen, Pavlov, Nikolay, Gianella, Pietro, Fischer, Reta, Charbonnier, Florian, Chaudhuri, Rekha, Smith, Steven James, Doe, Simon, Fawdon, Michelle, Masoli, Matthew, Heaney, Liam, Haitchi, Hans Michael, Kurukulaaratchy, Ramesh, Fulton, Olivia, Frankemolle, Betty, Gibson, Toni, Needham, Karen, Howarth, Peter, Djukanovic, Ratko, Bel, Elisabeth, and Hyland, Michael

Abstract

Background The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care. Methods In this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021. Results 1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on biologics, 24% experienced changes in biologic care, of whom 92% were changed to home-administered biologics and of these 62% were satisfied or very satisfied with this change. Only 2% reported worsening asthma symptoms associated with changes in biologic care. Many physicians expect continued implementation of video/phone consultations (41%) and home administration of biologics (52%). Conclusions Change to video/phone consultations and home administration of biologics was common in severe asthma care during the COVID-19 pandemic and was associated with high satisfaction levels in most but not all cases. Many physicians expect these changes to continue in future severe asthma care, though satisfaction levels may change after the pandemic.

Published
2022
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4. Heterogeneity in the use of biologics for severe asthma in Europe:a SHARP ERS study

Author

Frix, Anne Noelle, Heaney, Liam G., Dahlén, Barbro, Mihaltan, Florin, Sergejeva, Svetlana, Popović-Grle, Sanja, Sedlak, Vratislav, Lehtimäki, Lauri, Bourdin, Arnaud, Korn, Stephanie, Zervas, Eleftherios, Csoma, Zsuzsanna, Lúðvíksdóttir, Dora, Butler, Marcus, Canonica, Giorgio Walter, Grisle, Ineta, Bieksiene, Kristina, Ten Brinke, Anneke, Kuna, Piotr, Loureiro, Claudia Chaves, Nenasheva, Natalia M., Lazic, Zorica, Škrgat, Sabina, Ramos-Barbon, David, Leuppi, Joerg, Gemicioglu, Bilun, Bossios, Apostolos, Porsbjerg, Celeste M., Bel, Elisabeth H., Djukanovic, Ratko, Louis, Renaud, Frix, Anne Noelle, Heaney, Liam G., Dahlén, Barbro, Mihaltan, Florin, Sergejeva, Svetlana, Popović-Grle, Sanja, Sedlak, Vratislav, Lehtimäki, Lauri, Bourdin, Arnaud, Korn, Stephanie, Zervas, Eleftherios, Csoma, Zsuzsanna, Lúðvíksdóttir, Dora, Butler, Marcus, Canonica, Giorgio Walter, Grisle, Ineta, Bieksiene, Kristina, Ten Brinke, Anneke, Kuna, Piotr, Loureiro, Claudia Chaves, Nenasheva, Natalia M., Lazic, Zorica, Škrgat, Sabina, Ramos-Barbon, David, Leuppi, Joerg, Gemicioglu, Bilun, Bossios, Apostolos, Porsbjerg, Celeste M., Bel, Elisabeth H., Djukanovic, Ratko, and Louis, Renaud

Abstract

Introduction Treatment with biologics for severe asthma is informed by international and national guidelines and defined by national regulating bodies, but how these drugs are used in real-life is unknown. Materials and methods The European Respiratory Society (ERS) SHARP Clinical Research Collaboration conducted a three-step survey collecting information on asthma biologics use in Europe. Five geographically distant countries defined the survey questions, focusing on seven end-points: biologics availability and financial issues, prescription and administration modalities, inclusion criteria, continuation criteria, switching biologics, combining biologics and evaluation of corticosteroid toxicity. The survey was then sent to SHARP National Leads of 28 European countries. Finally, selected questions were submitted to a broad group of 263 asthma experts identified by national societies. Results Availability of biologics varied between countries, with 17 out of 28 countries having all five existing biologics. Authorised prescribers (pulmonologists and other specialists) also differed. In-hospital administration was the preferred deliverance modality. While exacerbation rate was used as an inclusion criterion in all countries, forced expiratory volume in 1 s was used in 46%. Blood eosinophils were an inclusion criterion in all countries for interleukin-5 (IL-5)-targeted and IL-4/IL-13-targeted biologics, with varying thresholds. There were no formally established criteria for continuing biologics. Reduction in exacerbations represented the most important benchmark, followed by improvement in asthma control and quality of life. Only 73% (191 out of 263) of surveyed clinicians assessed their patients for corticosteroid-induced toxicity. Conclusion Our study reveals important heterogeneity in the use of asthma biologics across Europe. To what extent this impacts on clinical outcomes relevant to patients and healthcare services needs further investigation.

Published
2022

5. The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?

Author

Eger, Katrien, primary, Paroczai, Dora, additional, Bacon, Alison, additional, Schleich, Florence, additional, Sergejeva, Svetlana, additional, Bourdin, Arnaud, additional, Vachier, Isabelle, additional, Zervas, Eleftherios, additional, Katsoulis, Konstantinos, additional, Papapetrou, Dimosthenis, additional, Kostikas, Konstantinos, additional, Csoma, Zsuzsanna, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Grisle, Ineta, additional, Bieksiene, Kristina, additional, Palacionyte, Jolita, additional, ten Brinke, Anneke, additional, Hashimoto, Simone, additional, Smeenk, Frank W.J.M., additional, Braunstahl, Gert-Jan, additional, van der Sar, Simone, additional, Mihălţan, Florin, additional, Nenasheva, Natalia, additional, Peredelskaya, Marina, additional, Zvezdin, Biljana, additional, Čekerevac, Ivan, additional, Hromiš, Sanja, additional, Ćupurdija, Vojislav, additional, Lazic, Zorica, additional, Milenkovic, Branislava, additional, Dimic-Janjic, Sanja, additional, Yasinska, Valentyna, additional, Dahlén, Barbro, additional, Bossios, Apostolos, additional, Lazarinis, Nikolaos, additional, Aronsson, David, additional, Egesten, Arne, additional, Munir, Abul Kashem Mohammad, additional, Ahlbeck, Lars, additional, Janson, Christer, additional, Škrgat, Sabina, additional, Edelbaher, Natalija, additional, Leuppi, Joerg, additional, Jaun, Fabienne, additional, Rüdiger, Jochen, additional, Pavlov, Nikolay, additional, Gianella, Pietro, additional, Fischer, Reta, additional, Charbonnier, Florian, additional, Chaudhuri, Rekha, additional, Smith, Steven James, additional, Doe, Simon, additional, Fawdon, Michelle, additional, Masoli, Matthew, additional, Heaney, Liam, additional, Haitchi, Hans Michael, additional, Kurukulaaratchy, Ramesh, additional, Fulton, Olivia, additional, Frankemölle, Betty, additional, Gibson, Toni, additional, Needham, Karen, additional, Howarth, Peter, additional, Djukanovic, Ratko, additional, Bel, Elisabeth, additional, and Hyland, Michael, additional

Published
2022
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8. Toward clinically applicable biomarkers for asthma : An EAACI position paper

Author

Diamant, Zuzana, Vijverberg, Susanne, Alving, Kjell, Bakirtas, Arzu, Bjermer, Leif, Custovic, Adnan, Dahlen, Sven-Erik, Gaga, Mina, van Wijk, Roy Gerth, Del Giacco, Stefano, Hamelmann, Eckard, Heaney, Liam G., Heffler, Enrico, Kalayci, Omer, Kostikas, Konstantinos, Lutter, Rene, Olin, Anna-Carin, Sergejeva, Svetlana, Simpson, Angela, Sterk, Peter J., Tufvesson, Ellen, Agache, Ioana, Seys, Sven F., Diamant, Zuzana, Vijverberg, Susanne, Alving, Kjell, Bakirtas, Arzu, Bjermer, Leif, Custovic, Adnan, Dahlen, Sven-Erik, Gaga, Mina, van Wijk, Roy Gerth, Del Giacco, Stefano, Hamelmann, Eckard, Heaney, Liam G., Heffler, Enrico, Kalayci, Omer, Kostikas, Konstantinos, Lutter, Rene, Olin, Anna-Carin, Sergejeva, Svetlana, Simpson, Angela, Sterk, Peter J., Tufvesson, Ellen, Agache, Ioana, and Seys, Sven F.

Abstract

Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their expression varies across the heterogeneous spectrum of asthma. Type 2 inflammatory responses are characterized by increased levels of eosinophils, FeNO, and type 2 cytokines in blood and/or airways. Presently, type 2 asthma is the best-defined endotype, typically found in patients with allergic asthma, but surprisingly also in nonallergic patients with (severe) asthma. The etiology of asthma with non-type 2 inflammation is less clear. During the past decade, targeted therapies, including biologicals and small molecules, have been increasingly integrated into treatment strategies of severe asthma. These treatments block specific inflammatory pathways or single mediators. Single or composite biomarkers help to identify patients who will benefit from these treatments. So far, only a few inflammatory biomarkers have been validated for clinical application. The European Academy of Allergy & Clinical Immunology Task Force on Biomarkers in Asthma was initiated to review different biomarker sampling methods and to investigate clinical applicability of new and existing inflammatory biomarkers (point-of-care) to support diagnosis, targeted treatment, and monitoring of severe asthma. Subsequently, we discuss existing and novel targeted therapies for asthma as well as applicable biomarkers.

Published
2019
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10. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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11. Peipsimaa vanausulised läbi aegade – rahvakultuur ja elu

Author

Sergejeva, Svetlana, Tóth, Szilárd Tibor, juhendaja, Tartu Ülikool. Humanitaarteaduste ja kunstide valdkond, and Tartu Ülikool. Eesti ja üldkeeleteaduse instituut

Subjects
rahvakultuur, magistritööd, vanausulised, rahvaluule
Abstract

https://www.ester.ee/record=b5161190*est

Published
2018

12. Toward clinically applicable biomarkers for asthma: An EAACI position paper

Author

Diamant, Zuzana, primary, Vijverberg, Susanne, additional, Alving, Kjell, additional, Bakirtas, Arzu, additional, Bjermer, Leif, additional, Custovic, Adnan, additional, Dahlen, Sven‐Erik, additional, Gaga, Mina, additional, Gerth van Wijk, Roy, additional, Del Giacco, Stefano, additional, Hamelmann, Eckard, additional, Heaney, Liam G., additional, Heffler, Enrico, additional, Kalayci, Ömer, additional, Kostikas, Konstantinos, additional, Lutter, Rene, additional, Olin, Anna‐Carin, additional, Sergejeva, Svetlana, additional, Simpson, Angela, additional, Sterk, Peter J., additional, Tufvesson, Ellen, additional, Agache, Ioana, additional, and Seys, Sven F., additional

Published
2019
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14. Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis

Author

Bossios Apostolos, Malmhäll Carina, Johansson Anna-Karin, Sergejeva Svetlana, Rådinger Madeleine, Sjöstrand Margareta, Lee James J, and Lötvall Jan

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background There is a growing body of evidence to suggest that CD8+ T lymphocytes contribute to local allergen-induced eosinophilic inflammation. Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process. Methods Several approaches were utilized. Firstly, mice overexpressing interleukin-5 (IL-5) in CD3+ T lymphocytes (NJ.1638; CD3IL-5+ mice) were bred with gene knockout mice lacking either CD4+ T lymphocytes (CD4-/-) or CD8+ T lymphocytes (CD8-/-) to produce CD3IL-5+ knockout mice deficient in CD4+ T lymphocytes (CD3IL-5+/CD4-/-) and CD8+ T lymphocytes (CD3IL-5+/CD8-/-), respectively. Secondly, CD3+, CD4+ and CD8+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice were adoptively transferred to immunodeficient SCID-bg mice to determine their effect on BM eosinophilia. Thirdly, CD3IL-5+, CD3IL-5+/CD8-/- and CD3IL-5+/CD4-/- mice were sensitized and allergen challenged. Bone marrow and blood samples were collected in all experiments. Results The number of BM eosinophils was significantly reduced in CD3IL-5+/CD8-/- mice compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice. Serum IL-5 was significantly higher in CD3IL-5+/CD4-/- mice compared to CD3IL-5+ mice but there was no difference in serum IL-5 between CD3IL-5+/CD4-/- and CD3IL-5+/CD8-/- mice. Adoptive transfer of CD8+, but not CD4+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice restored BM eosinophilia in immunodeficient SCID-bg mice. Additionally, allergen challenged CD3IL-5+/CD8-/- mice developed lower numbers of BM eosinophils compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice. Conclusion This study shows that CD8+ T lymphocytes are intricately involved in the regulation of BM eosinophilopoiesis, both in non-sensitized as well as sensitized and allergen challenged mice.

Published
2006
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15. Caplani sündroom. Haigusjuhu kirjeldus

Author

Melnikova, Renata, Pille, Andres, Bogovskaja, Jelena, Pille, Viive, and Sergejeva, Svetlana

Subjects
Caplani sündroom, reumatoidartriit, pneumokonioos
Abstract

Caplani sündroomi ehk reumatoidse pneumokonioosi patognoomiline tunnus on iseloomulik radioloogiline leid kopsudes reumatoidartriidi ja pneumokonioosiga patsientidel. Diferentsiaaldiagnoosideks on pahaloomulised kasvajad ja tuberkuloos. Caplani sündroomi ravi on sümptomaatiline, haigusspetsiifiline ravi puudub. Seetõttu jääb kõige olulisemaks haiguse profülaktika. Artiklis on kirjeldatud haigusjuhtu Caplani sündroomiga patsiendil, kellel iseloomulikud muutused kopsudes avastati rutiinse radioloogilise uuringu käigus. Diagnoosi õige hüpotees tekkis tänu põhjalikult võetud anamneesile, eelkõige tööanamneesile. Eesti Arst 2012; 91(7):361–367, Eesti Arst, August 2012

Published
2012
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17. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, and Rhyner, Claudio

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treat

Published
2012

18. Research needs in allergy:An EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A., Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A.

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and

Published
2012

19. Research needs in allergy:an EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform

Published
2012

26. Smoothened agonist augments proliferation and survival of neural cells

Author

Bragina, Olga, Sergejeva, Svetlana, Serg, Martin, Žarkovsky, Tamara, Maloverjan, Alla, Kogerman, Priit, and Žarkovsky, Aleksandr

Subjects
*HEDGEHOG signaling proteins, *DEVELOPMENTAL neurobiology, *CELLULAR signal transduction, *GENE expression, *CELL proliferation, *NEURON development, *NEURAL tube, *DENTATE gyrus
Abstract

Abstract: Sonic hedgehog signaling pathway is important in developmental processes like dorsoventral neural tube patterning, neural stem cell proliferation and neuronal and glial cell survival. Shh is also implicated in the regulation of the adult hippocampal neurogenesis. Recently, nonpeptidyl Smoothened activators of the Shh pathway have been identified. The aim of this study was to investigate the effects of chlorobenzothiophene-containing molecule, Smo agonist (SAG), which has been shown to activate Shh signaling pathway, in neurogenesis and neuronal survival in in vitro and in vivo models. Our in vitro experiments showed that SAG induces increased expression of Gli1 mRNA, transcriptional target and mediator of Shh signal. In vitro experiments also demonstrated that SAG in low-nanomolar concentrations induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. In contrast to Shh, SAG did not induce neurotoxicity in neuronal cultures. The SAG and Shh treatment also promoted the survival of newly generated neural cells in the dentate gyrus after their intracerebroventricular administration to adult rats. We propose that SAG and similar compounds represent attractive molecules to be developed for treatment of disorders where stimulation of the generation and survival of new neural cells would be beneficial. [ABSTRACT FROM AUTHOR]

Published
2010
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27. Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis.

Author

Rådinger, Madeleine, Sergejeva, Svetlana, Johansson, Anna-Karin, Malmhäll, Carina, Bossios, Apostolos, Sjöstrand, Margareta, Lee, James J., and Lötvall, Jan

Subjects
*LYMPHOCYTES, *EOSINOPHIL disorders, *BONE marrow diseases, *T cells, *MICE as carriers of disease, *IMMUNODEFICIENCY
Abstract

Background: There is a growing body of evidence to suggest that CD8+ T lymphocytes contribute to local allergen-induced eosinophilic inflammation. Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process. Methods: Several approaches were utilized. Firstly, mice overexpressing interleukin-5 (IL-5) in CD3+ T lymphocytes (NJ.1638; CD3IL-5+ mice) were bred with gene knockout mice lacking either CD4+ T lymphocytes (CD4-/-) or CD8+ T lymphocytes (CD8-/-) to produce CD3IL-5+ knockout mice deficient in CD4+ T lymphocytes (CD3IL-5+/CD4-/-) and CD8+ T lymphocytes (CD3IL-5+/CD8-/-), respectively. Secondly, CD3+, CD4+ and CD8+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice were adoptively transferred to immunodeficient SCID-bg mice to determine their effect on BM eosinophilia. Thirdly, CD3IL-5+, CD3IL-5+/CD8-/- and CD3IL-5+/CD4-/- mice were sensitized and allergen challenged. Bone marrow and blood samples were collected in all experiments. Results: The number of BM eosinophils was significantly reduced in CD3IL-5+/CD8-/- mice compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice. Serum IL-5 was significantly higher in CD3IL-5+/CD4-/- mice compared to CD3IL-5+ mice but there was no difference in serum IL-5 between CD3IL-5+/CD4-/- and CD3IL-5+/CD8-/- mice. Adoptive transfer of CD8+, but not CD4+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice restored BM eosinophilia in immunodeficient SCID-bg mice. Additionally, allergen challenged CD3IL-5+/CD8-/- mice developed lower numbers of BM eosinophils compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice. Conclusion: This study shows that CD8+ T lymphocytes are intricately involved in the regulation of BM eosinophilopoiesis, both in non-sensitized as well as sensitized and allergen challenged mice. [ABSTRACT FROM AUTHOR]

Published
2006
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29. Allergen exposure–induced differences in CD34+cell phenotype: relationship to eosinophilopoietic responses in different compartments

Author

Sergejeva, Svetlana, Johansson, Anna-Karin, Malmhäll, Carina, and Lötvall, Jan

Abstract

We hypothesized that the allergen-induced increased number of airway eosinophils results from increased recruitment of eosinophils from bone marrow (BM) and local development of CD34+cells into eosinophils. We also assumed that the phenotype of airway eosinophils depends on whether these cells have differentiated within BM or airway. C57BL/6 mice were sensitized and subsequently exposed to ovalbumin (OVA) on 5 consecutive days. Newly produced cells were labeled with a thymidine analog. Clonogenic activity and interleukin 5 (IL-5) release from bronchoalveolar lavage fluid (BALf) CD34+cells were evaluated by using cell-culture techniques. Allergen exposure induces increase in CD135+primitive myeloid progenitors within the BM CD34+cell population, without significant changes in total number of CD34+cells or newly produced CD34+cells. CD34+/IL-5Rα+cells in the first stage of cell differentiation were found only in BM, arguing that early commitment of CD34+cells into the eosinophil lineage is restricted to the BM compartment. Allergen exposure induces a shift in differentiation of BM, blood, and BALf eosinophillineage–committed CD34+cells toward mature eosinophils and recruitment of these cells via blood into airway. We further demonstrate in vitro that ability to multiply persists in BALf CD34+cells but not CD34–cells, likely via autocrine IL-5 release and IL-5–induced up-regulation of IL-5Rα.

Published
2004
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30. Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis.

Author

Rådinger M, Sergejeva S, Johansson AK, Malmhäll C, Bossios A, Sjöstrand M, Lee JJ, and Lötvall J

Subjects
Adoptive Transfer, Animals, Bronchoalveolar Lavage Fluid cytology, CD3 Complex analysis, CD3 Complex genetics, CD4 Antigens analysis, CD4 Antigens genetics, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes transplantation, CD8 Antigens analysis, CD8 Antigens genetics, CD8-Positive T-Lymphocytes transplantation, Eosinophil Major Basic Protein biosynthesis, Interleukin-5 biosynthesis, Interleukin-5 blood, Interleukin-5 genetics, Leukocyte Count, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, SCID, Ovalbumin, Pulmonary Eosinophilia blood, Respiratory Hypersensitivity blood, T-Lymphocyte Subsets transplantation, Bone Marrow Cells immunology, CD8-Positive T-Lymphocytes immunology, Eosinophils immunology, Leukopoiesis, Pulmonary Eosinophilia immunology, Respiratory Hypersensitivity immunology, T-Lymphocyte Subsets immunology
Abstract

Background: There is a growing body of evidence to suggest that CD8+ T lymphocytes contribute to local allergen-induced eosinophilic inflammation. Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process., Methods: Several approaches were utilized. Firstly, mice overexpressing interleukin-5 (IL-5) in CD3+ T lymphocytes (NJ.1638; CD3IL-5+ mice) were bred with gene knockout mice lacking either CD4+ T lymphocytes (CD4-/-) or CD8+ T lymphocytes (CD8-/-) to produce CD3IL-5+ knockout mice deficient in CD4+ T lymphocytes (CD3IL-5+/CD4-/-) and CD8+ T lymphocytes (CD3IL-5+/CD8-/-), respectively. Secondly, CD3+, CD4+ and CD8+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice were adoptively transferred to immunodeficient SCID-bg mice to determine their effect on BM eosinophilia. Thirdly, CD3IL-5+, CD3IL-5+/CD8-/- and CD3IL-5+/CD4-/- mice were sensitized and allergen challenged. Bone marrow and blood samples were collected in all experiments., Results: The number of BM eosinophils was significantly reduced in CD3IL-5+/CD8-/- mice compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice. Serum IL-5 was significantly higher in CD3IL-5+/CD4-/- mice compared to CD3IL-5+ mice but there was no difference in serum IL-5 between CD3IL-5+/CD4-/- and CD3IL-5+/CD8-/- mice. Adoptive transfer of CD8+, but not CD4+ T lymphocytes from naïve CD3IL-5+ and C57BL/6 mice restored BM eosinophilia in immunodeficient SCID-bg mice. Additionally, allergen challenged CD3IL-5+/CD8-/- mice developed lower numbers of BM eosinophils compared to CD3IL-5+ mice and CD3IL-5+/CD4-/- mice., Conclusion: This study shows that CD8+ T lymphocytes are intricately involved in the regulation of BM eosinophilopoiesis, both in non-sensitized as well as sensitized and allergen challenged mice.

Published
2006
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