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3 results on '"Serena Rechichi"'

1. Electroencephalographic features in patients undergoing extracorporeal membrane oxygenation

Author

Lorenzo Peluso, Serena Rechichi, Federico Franchi, Selene Pozzebon, Sabino Scolletta, Alexandre Brasseur, Benjamin Legros, Jean-Louis Vincent, Jacques Creteur, Nicolas Gaspard, and Fabio Silvio Taccone

Subjects
ECMO, Electroencephalogram, EEG, Outcome, Neurological complication, Cardiac arrest, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Neurologic injury is one of the most frequent causes of death in patients undergoing extracorporeal membrane oxygenation (ECMO). As neurological examination is often unreliable in sedated patients, additional neuromonitoring is needed. However, the value of electroencephalogram (EEG) in adult ECMO patients has not been well assessed. Therefore, the aim of this study was to assess the occurrence of electroencephalographic abnormalities in patients treated with extracorporeal membrane oxygenation (ECMO) and their association with 3-month neurologic outcome. Methods Retrospective analysis of all patients undergoing venous–venous (V–V) or venous–arterial (V–A) ECMO with a concomitant EEG recording (April 2009–December 2018), either recorded intermittently or continuously. EEG background was classified into four categories: mild/moderate encephalopathy (i.e., mostly defined by the presence of reactivity), severe encephalopathy (mostly defined by the absence of reactivity), burst-suppression (BS) and suppressed background. Epileptiform activity (i.e., ictal EEG pattern, sporadic epileptiform discharges or periodic discharges) and asymmetry were also reported. EEG findings were analyzed according to unfavorable neurological outcome (UO, defined as Glasgow Outcome Scale

Published
2020
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2. Homocysteine and P wave dispersion in patients with heart transplantation

Author

Serena Rechichi, Maurizio Acampa, Massimo Maccherini, Pier Leopoldo Capecchi, Pietro Enea Lazzerini, Franco Laghi-Pasini, and Francesca Guideri

Subjects
Heart transplantation, Transplantation, medicine.medical_specialty, education.field_of_study, Hyperhomocysteinemia, medicine.diagnostic_test, Heart disease, Homocysteine, business.industry, medicine.medical_treatment, Population, medicine.disease, QT interval, chemistry.chemical_compound, chemistry, Internal medicine, Anesthesia, medicine, Cardiology, Risk factor, education, business, Electrocardiography
Abstract

Acampa M, Lazzerini PE, Guideri F, Rechichi S, Capecchi PL, Maccherini M, Laghi-Pasini F. Homocysteine and P wave dispersion in patients with heart transplantation. Clin Transplant 2011: 25: 119–125. © 2009 John Wiley & Sons A/S. Abstract: Background: Hyperhomocysteinemia (HHcy), a putative independent risk factor for the development of atherotrombosis in the general population, represents a very common finding in orthotopic heart transplantation (OHT) patients. Starting from previous studies suggesting a pro-arrhythmogenic activity of homocysteine (Hcy), we evaluated the possible correlation among Hcy plasma levels and P wave dispersion (PWD), corrected QT interval (QTc), and QTc dispersion (QTcD) as parameters of electric instability of the myocardium in patients undergone OHT whose hearts are therefore completely denervated, thus unresponsive to autonomic influences. Methods and results: Homocysteine plasma levels, PWD, QTc, QTcD, and QTc dynamics were measured in 32 patients, who underwent OHT, and in 20 control subjects. In OHT patients, PWD (39.5 ± 11 vs. 34 ± 6 ms, p = 0.04) and QTc interval (438 ± 20 vs. 410 ± 10 ms, p

Published
2011
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3. Cyclosporin and tacrolimus increase plasma levels of adenosine in kidney transplanted patients

Author

Francesca Guideri, Franco Laghi-Pasini, Mario Carmellini, Pietro Enea Lazzerini, A. Collini, Serena Rechichi, Pier Leopoldo Capecchi, and Giuliana Ruggieri

Subjects
Adult, Male, medicine.medical_specialty, Adenosine, Adenosine kinase, Tacrolimus, Nephrotoxicity, Internal medicine, medicine, Humans, Aged, Antibacterial agent, Transplantation, Kidney, biology, business.industry, Middle Aged, Kidney Transplantation, Calcineurin, medicine.anatomical_structure, Endocrinology, Cyclosporine, biology.protein, Female, business, Immunosuppressive Agents, medicine.drug
Abstract

Summary The immunosuppressive agents, cyclosporin (CsA) and tacrolimus (FK506), display cardioprotective activities. The mechanism would consist on the inhibition of the enzyme, adenosine kinase (AK), leading to an increase in adenosine (ADO) levels. ADO, inosine (INO) and nucleotide plasma levels were measured in kidney transplant recipients before and 1, 2, 4, 6 and 8 h after the administration of CsA or FK506. After CsA and FK506 administration, ADO plasma levels significantly increased, reaching a peak level after 2 h (483 ± 124 and 429 ± 96 nm, respectively), and then progressively declined. Calculated peak values (tmax) of ADO were slightly delayed with respect to those of CsA and FK506. Treatment with rapamycin did not influence the phenomenon. The dynamic profile of plasma changes of ADO, nucleotides and INO were consistent with the inhibition of the enzyme, AK. ADO increase may be clinically relevant in terms of anti-ischaemic, tissue protecting, and immunosuppressive activities as well as in terms of nephrotoxicity.

Published
2005
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