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Background: Previous studies have shown that chemerin has important roles in the development of obesity, insulin resistance, metabolic syndrome, polycystic ovary syndrome (PCOS) and T2DM. The main goal of our study was to investigate the role of Chemerin rs17173608 gene polymorphism in T2DM (type 2 diabetes mellitus). Materials and methods: 100 patients with T2DM and 50 healthy volunteers were included in the present study. DNA isolation from blood samples was performed with K1820-02 DNA Mini Kit. Chemerin gene polymorphism was detected by Tetra- Amplification Refractory mutation system polymerase chain reaction (T-ARMS-PCR). At the end of T-ARMS-PCR, samples were run using gel electrophoresis. Some samples were validated by sequence analysis. Results: In the genotype analysis, 18.0% of patients had TT genotype and 81.0% of TG genotype was detected. GG genotype was not detected in any patient. Genotype of 1 patient was unidentified. Genotype distribution of healthy control group was 12.0% TT genotype and 88.0% TG genotype. Similar to the T2DM group, the GG genotype was not detected in the control group. There was no statistically significant difference between T2DM group and healthy control group for TG and TT genotypes. Conclusion: To our knowledge, chemerin rs17173608 gene polymorphism has been investigated in T2DM for the first time herein. In the present study, the TT genotype ratios were higher in the T2DM subjects than in healthy subjects. G allele frequency in the T2DM group was lower than that in the control group. However, there was no statistically significant difference between the groups.

AIM To investigate the effect of septoplasty in patients with nasal septum deviation (NSD) on erythropoietin (EPO) and hemoglobin (Hgb) levels. METHODS Between 2017 December and 2018 May, 47 patients with NSD who underwent septoplasty in Adiyaman University Medical Faculty Department of Otorhinolaryngology included in this prospective study. The changes in EPO and Hgb levels were studied before and 3 months after the surgery. RESULTS The mean age of the patients studied was 30.7 ± 9.9. 31 of the patients were male and 16 were female. Pre- and post-operative 3rd month mean EPO levels of the patients were 11.45 ± 4.9 Mu/mL and 11.39 ± 6.02 Mu/mL, respectively. When these values were analyzed, no statistically significant difference was found (P = .93). Pre- and post-operative 3rd month mean Hgb levels were 14.6 g/dL, and 14.6 g/dL, in turn. When these values were analyzed, no statistically significant difference was found (P = .68). CONCLUSION According to these results, the author can say there is no statistically significant relationship between NSD and EPO or Hgb. Therefore, this issue will be enlightened with future studies including more patients and objective tests evaluating nasal patency.

Objective. To investigate the relationship between sarcopenia and diabetic nephropathy. Methods. 56 diabetic patients without complications, 50 diabetic patients with nephropathy, 53 healthy controls included in this present study. Demographic characteristics such as sex, age, anthropometric measurements such as weight, body mass index [BMI], hip circumference, waist circumference and upper arm circumference were measured. Sarcopenia diagnosis was based on European Working Group on Sarcopenia in Older People [EWGSOP] criteria which consist of hand grip strength, 6-meter walking test and muscle mass. Results. The frequency of sarcopenia increased gradually from 15.1% in healthy control group to 21.4% in the diabetes group, and 34% in diabetic nephropathy group (X2 for trend, p = 0.029). The frequency of sarcopenia was similar in diabetes and diabetic nephropathy group. However, the frequency of sarcopenia was higher in diabetic nephropathy than healthy controls (OR = 2.89, CI [1.11-7.51] in logistic regression). Conclusion: In the present study, the prevalence of sarcopenia was higher in patients with diabetic nephropathy compared to healthy controls.

Bilgiye erisimin kolaylastigi gunumuzde, maalesef her birimiz zaman zaman; pratik, ayrintidan uzak ve hedefe yonelik bilgiye ulasmakta zorlanmisizdir. Elinizdeki bu eser, sahada birebir vaka gorup aktif calisan hekimlerimiz tarafindan kaleme alinmis olup kolay, anlasilir, ayrintidan uzak ve hedefe yonelik bilgileri vakalar uzerinden okuyucuya ulastirmayi hedeflemektedir. Aile hekimleri, ic hastaliklari hekimleri, endokrinoloji alaninda calisan ya da tiroid hastaliklari ile ilgilenen tum meslektaslarimizin ilgiile okuyup faydalanabilecegi bir kaynak olusturuldugu kanaatindeyiz. Siz degerli meslektaslarimizin geri bildirimleri ile bir sonraki baski ve eserde huzurlariniza daha oz guvenli cikmayi umuyoruz

Aim: To investigate impact of the hypothyroidism on hematological parameters.Material and Method: Twenty patients with hypothyroidism and twenty two healthy subjects were enrolled in this study between February 2015 and July 2015. We collected clinical and laboratory data of patients with hypothyroidism and randomized healthy subject’s from the Adıyaman University Medical Faculty Hospital records retrospectively. The patients with anemia, rheumatic diseases, chronic kidney diseases, chronic liver diseases, chronic obstructive pulmonary disease, chronic heart diseases, inflammatory bowel diseases, malignancy and acute infections were excluded from the study. Patients were divided into two groups; hypothyroid group and healthy group. TSH values were increased in all of the hypothyroid patients. We compared hematological parameters consist of hemoglobin, platelet count, white blood cell (WBC), red cell distribution width (RDW) and mean platelet volume (MPV) between the two groups. Results: 70% of patients with hypothyroidism were female and 30% of patients were male. Mean age of patients with hypothyroidism were 44,8±13,4. 72,7% of healthy subjects were female and 27,3% of healthy subjects were male. Mean age of healthy subjects was 31±14,6. In the result with Independent sample T test increased RDW-CV values was significantly associated with hypothyroidism (P value =0.01). The other hematological parameters weren’t different between the groups (P value >0.05).Conclusion: The present study demonstrated that increased RDW values was associated with hypothyroidism. Key words: Hypothyroidism, RDW, MPV

Background: Inflammatory hematological parameters like the neutrophil/lymphocyte (N/L) ratio have been investigated in many cancer types and significant relationships found with prognosis, for example. The aim of this present study was to investigate the impact of hematological parameters notably on N/L ratio and mean platelet volume (MPV) in papillary thyroid cancer cases. Materials and Methods: A total of 79 patients who underwent a thyroidectomy operation in Findikli, Goiter Research and Treatment Center during 2011- 2015 period were enrolled in the study, 41 with papillary thyroid cancer and 38 with benign goiter confirmed by pathological examination. We collected clinical and laboratory data for the patients from hospital records retrospectively. Blood samples taken at admission were assessed for parameters compared between the groups. Results: No significant differences between papillary thyroid cancer and benign goiter groups were apparent in terms of age, the N/L ratio, MPV, white blood cell count (WBC), red blood cell count (RBC), hemoglobin, hematocrit, platelet, neutrophil, lymphocyte, red blood cell distribution width (RDW) and platelet crit (PCT) levels (>0.05). Only the level of platelet distribution width (PDW) significantly differed, being lower in the papillary cancer group (

AIM: To investigate the effect of bariatric surgery on HbA1c and serum cortisol levels in morbidly obese patients without type 2 diabetes mellitus.MATERIALS AND METHODS: Twenty-nine patients who underwent sleeve gastrectomy and whose body mass index was> 40 were included in the present study. Patients' files were reviewed retrospectively. Those with diabetes mellitus and those with age

Introduction: This study aimed to investigate the relationship between trace element levels and T2DM in patients from Adıyaman province in southeastern Turkey.Materials and Methods: This study included 49 healthy subjects and 80 patients diagnosed with T2DM. The study population was divided into healthy controls and patients with T2DM and good glycemic control (GGC) and with T2DM and poor glycemic control (PGC). Biochemical parameters and trace element levels were compared in the three groups.Results: Fasting blood glucose (FBG) and triglyceride (TG) levels were significantly higher in both diabetic groups and were higher in the PGC than in the GGC group (p

Introduction: The aim of this study was to investigate the relationship between HbA1c and carotid intima-media thickness (cIMT) which is noninvasive marker of atherosclerosis in type 2 diabetic patients. Methods: 81 type 2 diabetic patients were enrolled in this study. Demographic, clinical and laboratory features of the patients were obtained from hospital records. cIMT values were measured by high resolution B-mode ultrasound. Patients were divided into two groups according to cIMT values: cIMT < 0,9 mm group and cIMT ≥ 0,9 mm group. Increased cIMT values were accepted as ≥ 0,9 mm. Then we compared HbA1c and other collected features between normal and increased cIMT groups. Results: 69,2% of the patients were female, 30,8% were male. The mean age of the patients were 58,4±10,7 year. The mean HbA1c values of the patients were 8,6±2,03%. The mean cIMT values of the patients were 0,74±0,22 mm. Result with Student T test and ROC curve analysis HbA1c values were’nt different between the groups (p >0.05). Conclusion: in this present study we demonstrated that HbA1c could not be a marker for subclinical atherosclerosis in diabetic patients.Pan African Medical Journal 2016; 2

Cirrhotic patients admitted to the hospital have a high mortality rate. The aim of this study was to evaluate predictors of mortality in patients hospitalized for specific complications of cirrhosis.All patients admitted to the gastroenterology service with cirrhosis during a 2-year period were retrospectively identified. We compared the clinical characteristics of patients who died and those who survived. Multivariable analysis was performed to determine predictors of mortality.A total of 84 patients were included in the study. In hospital mortality rate was 35%. Hepatorenal syndrome development (41% vs 4%, p0.001), MELD score (17 vs 12, p = 0.003), Child Pugh score (11 vs 8, p0.001), serum creatinine (p0.001) and serum potassium values (p = 0.01) were significantly higher in patients who died. Stepwise logistic regression analysis revealed that the best model in prediction of death included serum potassium levels (OR = 2.182; 95% Cl: 1.189-4.006; p0.001) and Child Pugh score (OR = 2.140; 95% CI: 1.507-3,038; p = 0.012).The mortality of cirrhotic patients admitted to hospital is significantly high. Prevention of acute kidney injury will be an appropriate approach for improving the survival in hospitalized patients with cirrhosis.

Tinnitus is the perception of sound with no external stimulus and idiopathic subjective tinnitus is the most common type in adults. Mean platelet volume (MPV) alterations were shown in some inflammatory diseases and were evaluated as a clinically useful marker. Our aim was to investigate MPV alterations in idiopathic subjective tinnitus patients. A total of 101 patients and 54 age- and sex-matched healthy control subjects were enrolled in the study. Patients included in the study had complaints of tinnitus for at least 3 months. All patients underwent detailed otolaryngologic examination, blood sampling, pure tone audiometry, magnetic resonance imaging of ear, and vertebrobasilar artery Doppler ultrasonography to make the differential diagnosis of tinnitus. Blood sampling consisted of renal-liver-thyroid function tests, lipid profile, and complete blood count. All tests and examinations except the imaging modalities were also performed for the control group. There were no differences in age and sex distribution of groups. Mean platelet volume values were significantly increased in tinnitus patients when compared with controls (p = 0.001). We think that MPV can be qualified as a useful marker in tinnitus patients.

Sarcoidosis is a systemic granulomatous disorder and most often involve in lung, rarely may present with bone marrow involvement. Hematologic anomalies can be determined in patients with bone marrow involvement, but it is not a rule. A 47-year-old woman patient having complaints from backache, difficulty in walking and weakness in bilateral lower extremities admitted to our hospital we detected bicytopenia and lesion in L2-L3 vertebrae. Patient was operated. After pathological investigation of lesion we diagnosed bone marrow involvement of sarcoidosis. Lung and the other organs systems were normal. A-74-year-old woman patient having complaints from malaise and fatigue admitted to our hospital, we detected pancytopenia and vertebral lesion than we applied bone marrow biopsy from the lesion. After bone marrow biopsy we diagnosed bone marrow involvement of sarcoidosis. In other investigations lung involvement with mediastinal lymphadenopathy was detected and the other organ systems were normal. Here we presented two cases diagnosed with bone marrow involvement of sarcoidosis which is seen rarely., Sarkoidoz sistemik granülomatöz bir hastalıktır ve en sık akciğerleri tutar, nadir olarak kemik iliği tutulumu ile seyredebilir. Kemik iliği tutulumu olan hastalarda hematolojik anormallikler saptanabilmektedir. 47 yaşında bel ağrısı, yürümede güçlük ve çift taraflı alt ekstremitelerde güçsüzlük şikayetleri olan bayan hastada bisitopeni ve L2-L3 vertebrada lezyon saptandı. Hasta opere edildi. Lezyonun patolojik incelemesi sonucu sarkoidoz tanısı kondu. Yapılan diğer incelemeler sonucunda Akciğerde sarkoidoz tutulumu saptandı. 74 yaşında halsizlik ve yorgunluk şikayetleri olan bayan hastada yapılan tetkiklerde pansitopeni saptanması üzerine kemik iliği biyopsisi yapıldı. Kemik iliğinin patolojik olarak incelemesi sonucunda sarkoidozla uyumlu non-kazeifiye granülom saptandı. Yapılan diğer incelemelerde başka bir tutulum saptanmadı. Burada nadir görülen kemik iliği sarkoidozu saptanan iki olguyu sunduk.

Aim: Nasal septum deviation (NSD) is an important cause of upper respiratory tract obstruction. Alveolar hypoventilation can occur in patients with severe NSD. In some studies, hypoxia has been found to increase platelet activation. Thus,herein weaimed to investigate the impact of the NSD and septoplasty on platelet indices. Material and Methods: 100 patients with NSD were enrolled in this present study retrospectively between December 2015 and October 2016.NSD diagnosed by anterior rhinoscopy and trans-nasal endoscopic examination. Septoplasty was performed with the help of Killian or hemitransfixion incision under general anesthesia. The haemogram results including platelets indiceswere investigated from recorded hospital database retrospectively. Results: 56 of the patients were males and 44 of the patients were females. Mean age of the patients was 25.7±10.2 year. Threemonthsafter surgery mean platelet volume (MPV) values were significantly decreased when compared with preoperative values(p value

Here we wanted to investigate predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the diagnosis of brucellosis. Thirty-two brucellosis patients diagnosed with positive serum agglutination test and thirty-two randomized healthy subjects were enrolled in this study retrospectively. Result with ROC analyzes the baseline NLR and hemoglobin values were found to be significantly associated with brucellosis (P=0.01,P=0.01, resp.). Herein we demonstrated for the first time that NLR values were significantly associated with brucellosis. This situation can help clinicians during diagnosis of brucellosis.

To the Editor, Anti-mitochondrial antibody (AMA) is a highly specific and sensitive test for primary biliary cirrhosis (PBC). It can also be detected as positive in connective tissue diseases, such as scleroderma, CREST, systemic lupus erythematosus, and Sjogren’s syndrome (1). In general, HEp-2 cells are analyzed with immunofluorescence microscopic and/or extractable nuclear antigen (ENA) tests in rat liver and kidney tissues. Recently, the increasing request for ENA tests used in the diagnosis of autoimmune diseases by rheumatology clinics has led to a frequent encounter with the AMA M2 positivity present in these tests. In this study, we aimed to retrospectively evaluate patients with AMA M2 detected as positive in microbiology laboratories.

Demodex folliculorum and Demodex brevis are obligatory parasites that live in sebaceous glands and follicles. When immune system becomes suppressed by any reason, patients become vulnerable to obligatory parasites like D. folliculorum and D. brevis. Immune system becomes suppressed in cancer patients who undergo chemotherapy, and as a result these patients become vulnerable to infestations. In our case, a 45 year-old female has been admitted to oncology clinic for a medical treatment of breast cancer. Her systematic physical examination was normal, except redness on her cheeks and forehead. There was no abnormality in biochemical and haematological laboratory values. We have decided to apply chemotherapy of Adriamycin, cyclophosphamide and 5-fluorouracil. Due to the itchy redness on her cheeks and forehead, we had performed an examination for demodex before chemotherapy; and we have identified 20 mites/cm² on her right and left cheeks, and 15 mites/cm² on her forehead. When our patient had came our clinic with increasing complaint of itchy rash, after the first course of chemotherapy we have reexamined demodex. The result of microscopic examination revealed large amount of demodex of 50 mites/cm² on her right and left cheeks and 30 mites/cm² on her forehead, which were nearly 2.5-times higher than the previous examination. This increase probably was associated with immune suppression of chemotherapy.Keywords: Chemotherapy, demodex, infestation

e17685 Background: Cancer is a stressful situation itself and brings along a number of psychiatric disorders, which are frequently encountered as depression and sleep disorders. The purpose of this...

Rarely, intrahepatic cholestasis may occur during the course of Graves' disease. It is important to rule out other causes of intrahepatic cholestasis for diagnosis. In this article, we present a case of intrahepatic cholestasis due to Graves' disease in a 52-year-old male patient with jaundice, pruritus, and weight loss.

Conclusions: Taking the medication on a full stomach or in the evening, occasional use of medication, storing the medicine in the refrigerator, and the use of additional medications were the major factors for insufficient TSH levels. Appropriate usage of levothyroxine pills is crucial for successful treatment.