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267 results on '"Seravalli, Viola"'

7. Schwann Cell C5aR1 co-opts Inflammasome NLRP1 to Sustain Pain in a Mouse Model of Endometriosis

Author

De Logu, Francesco, primary, Titiz, Mustafa, additional, Landini, Lorenzo, additional, de Araujo, Daniel Souza Monteiro, additional, Marini, Matilde, additional, Seravalli, Viola, additional, Chieca, Martina, additional, Pensieri, Pasquale, additional, Montini, Marco, additional, De Siena, Gaetano, additional, Pasquini, Benedetta, additional, Vannuccini, Silvia, additional, Iannone, Luigi, additional, Brancolini, Giulia, additional, Bellantoni, Elisa, additional, Scuffi, Irene, additional, Mastricci, Alessandra, additional, Tesi, Martina, additional, Tommaso, Mariarosaria Di, additional, Petraglia, Felice, additional, Geppetti, Pierangelo, additional, and Nassini, Romina, additional

Published
2024
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8. Endocrinology of Maternal-Placental Axis

Author

Seravalli, Viola, Di Tommaso, Mariarosaria, Challis, John, Petraglia, Felice, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Petraglia, Felice, editor, and Fauser, Bart C., editor

Published
2020
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18. Exploring Plasma-Level Gut Microbiota Mediators and Pro-Inflammatory Markers in Pregnant Women with Short Cervix and Gestational Diabetes Mellitus

Author

Silvano, Angela, primary, Niccolai, Elena, additional, Baldi, Simone, additional, Seravalli, Viola, additional, Strambi, Noemi, additional, Nannini, Giulia, additional, Pallecchi, Marco, additional, Bartolucci, Gianluca, additional, Parenti, Astrid, additional, Amedei, Amedeo, additional, and Di Tommaso, Mariarosaria, additional

Published
2023
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35. Vaginal Microbiome in Pregnant Women with and without Short Cervix.

Author

Silvano, Angela, Meriggi, Niccolò, Renzi, Sonia, Seravalli, Viola, Torcia, Maria Gabriella, Cavalieri, Duccio, and Di Tommaso, Mariarosaria

Abstract

Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length ≤25 mm and in 29 pregnant women with a cervix >25 mm in the second or early third trimester. Illumina protocol 16S Metagenomic Sequencing Library Preparation was used to detail amplified 16SrRNA gene. Statistical analyses were performed in R environment. Firmicutes was the phylum most represented in all pregnant women. The mean relative abundance of Proteobacteria and Actinobacteriota was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix. Staphylococcus and Pseudomonas, taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while Lactobacillus iners and Bifidobacterium were associated with a normal cervical length. Lactobacillus jensenii and Gardenerella vaginalis were associated with a short cervix. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Effectiveness of cervical pessary in women with arrested preterm labor compared to those with asymptomatic cervical shortening.

Author

Seravalli, Viola, Campana, Dante, Strambi, Noemi, Vialetto, Debora, and Di Tommaso, Mariarosaria

Subjects
*PREMATURE labor, *EDIBLE fats & oils, *PREMATURE rupture of fetal membranes, *MULTIPLE pregnancy, *ASYMPTOMATIC patients
Abstract

Objective To determine whether the effectiveness of cervical pessary is different in women who experienced cervical shortening after a threatened preterm labor episode compared to those with asymptomatic short cervix. Methods Retrospective study on singleton pregnancies at risk for preterm delivery (PTD) due to cervical length <25 mm before 28 weeks, who were treated with Arabin cervical pessary. Two groups of patients were compared: those who had contractions causing shortening of the cervix, prior to pessary placement, and those who had asymptomatic cervical shortening. Patients carrying a multiple pregnancy and those who underwent iatrogenic PTD were excluded. The primary outcome was the incidence of PTD at different gestational ages. Secondary outcome was the rate of preterm premature rupture of membrane (pPROM). The groups were compared using univariate and multivariate analyses. Results 115 patients that met the inclusion criteria were identified. Of these, 91 (79%) had asymptomatic cervical shortening, while 24 (21%) had an episode of threatened preterm labor that resolved, and the pessary was placed after the contractions had stopped. The two groups were similar for maternal characteristics, obstetric history, mean gestational age and length of the cervix at the time of pessary insertion. The median gestational age at delivery was significantly lower (36.4 vs 38.0 weeks, p = .02), and the incidence of PTD significantly higher (58.3% vs 30.8%, OR 4.69, 95% CI 1.68–13.1, p < .01) among women who had arrested preterm labor before the pessary was placed compared to the asymptomatic group, after controlling for confounders. The incidence of PTD before 34 and before 32 weeks was also significantly higher in the symptomatic group (p = .02 and p = .005, respectively). Women with asymptomatic cervical shortening had a longer interval between the placement of the pessary and delivery (median 15 weeks). pPROM occurred with a similar incidence in both groups. Conclusions Arabin cervical pessary to prevent preterm delivery seems be less effective in women with a short cervix following an episode of threatened preterm labor than in those with asymptomatic cervical shortening in the second trimester. This finding may help physicians to select patients in which cervical pessary is more likely to be effective, and to improve patient’s counseling about this intervention. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Inpatientvsoutpatient management and timing of delivery of uncomplicated monochorionic monoamniotic twin pregnancy: the MONOMONO study

Author

Saccone, Gabriele, Berghella, Vincenzo, Locci, Mariavittoria, Ghi, Tullio, Frusca, Tiziana, Lanna, Mariano, Faiola, Stefano, Fichera, Anna, Prefumo, Federico, Rizzo, Giuseppe, Bosi, Costanza, Arduino, Bruno, D'Alessandro, Pietro, Borgo, Maria, Arduino, Silvana, Cantanna, Elisabetta, Simonazzi, Giuliana, Rizzo, Nicola, Francesca, Giorgetta, Seravalli, Viola, Miller, Jena L., Magro-Malosso, Elena Rita, Di Tommaso, Mariarosaria, Dall'Asta, Andrea, Galli, Letizia, Volpe, Nicola, Visentin, Silvia, Cosmi, Erich, Sarno, Laura, Caissutti, Claudia, Driul, Lorenza, Anastasio, Hannah, Di Mascio, Daniele, Panici, Pierluigi Benedetti, Vena, Flaminia, Brunelli, Roberto, Ciardulli, Andrea, D'Antonio, Francesco, Schoen, Corina, Suhag, Anju, Gambacorti-Passerini, Zita Maria, Baz, Maria Angeles Anaya, Magoga, Giulia, Busato, Enrico, Filippi, Elisa, Suárez, María José Rodriguez, Alderete, Francisco Gamez, Ortuno, Paula Alonso, Vitagliano, Amerigo, Mollo, Antonio, Raffone, Antonio, Vendola, Marianne, Navaneethan, Preethi, Wimalasundera, Ruwan, Napolitano, Raffaele, Aquino, Carmen Imma, D'Agostino, Serena, Gallo, Cinzia, Maruotti, Giuseppe Maria, Flacco, Maria Elena, Baschat, Ahmet A., Venturella, Roberta, Guida, Maurizio, Martinelli, Pasquale, Zullo, Fulvio, Saccone G, Berghella V, Locci M, Ghi T, Frusca T, Lanna M, Faiola S, Fichera A, Prefumo F, Rizzo G, Bosi C, Arduino B, D'Alessandro P, Borgo M, Arduino S, Cantanna E, Simonazzi G, Rizzo N, Francesca G, Seravalli V, Miller JL, Magro-Malosso ER, Di Tommaso M, Dall'Asta A, Galli L, Volpe N, Visentin S, Cosmi E, Sarno L, Caissutti C, Driul L, Anastasio H, Di Mascio D, Panici PB, Vena F, Brunelli R, Ciardulli A, D'Antonio F, Schoen C, Suhag A, Gambacorti-Passerini ZM, Baz MAA, Magoga G, Busato E, Filippi E, Suárez MJR, Alderete FG, Ortuno PA, Vitagliano A, Mollo A, Raffone A, Vendola M, Navaneethan P, Wimalasundera R, Napolitano R, Aquino CI, D'Agostino S, Gallo C, Maruotti GM, Flacco ME, Baschat AA, Venturella R, Guida M, Martinelli P, Zullo F., Saccone, G., Berghella, V., Locci, M., Ghi, T., Frusca, T., Lanna, M., Faiola, S., Fichera, A., Prefumo, F., Rizzo, G., Bosi, C., Arduino, B., D'Alessandro, P., Borgo, M., Arduino, S., Cantanna, E., Simonazzi, G., Rizzo, N., Francesca, G., Seravalli, V., Miller, J. L., Magro-Malosso, E. R., Di Tommaso, M., Dall'Asta, A., Galli, L., Volpe, N., Visentin, S., Cosmi, E., Sarno, L., Caissutti, C., Driul, L., Anastasio, H., Di Mascio, D., Panici, P. B., Vena, F., Brunelli, R., Ciardulli, A., D'Antonio, F., Schoen, C., Suhag, A., Gambacorti-Passerini, Z. M., Baz, M. A. A., Magoga, G., Busato, E., Filippi, E., Suarez, M. J. R., Alderete, F. G., Ortuno, P. A., Vitagliano, A., Mollo, A., Raffone, A., Vendola, M., Navaneethan, P., Wimalasundera, R., Napolitano, R., Aquino, C. I., D'Agostino, S., Gallo, C., Maruotti, G. M., Flacco, M. E., Baschat, A. A., Venturella, R., Guida, M., Martinelli, P., and Zullo, F.

Subjects
Cardiotocography, chorionicity, Twins, Cesarean delivery, cord accident, cord entanglement, healthcare, monochorionic, multiple gestation, perinatal death, respiratory distress syndrome, twin pregnancy, Radiological and Ultrasound Technology, Reproductive Medicine, Radiology, Nuclear Medicine and Imaging, Obstetrics and Gynecology, 0302 clinical medicine, Pregnancy, Nuclear Medicine and Imaging, Outpatients, Health care, Prenatal, Medicine, 030212 general & internal medicine, Twin Pregnancy, Monochorionic monoamniotic twin pregnancy, Ultrasonography, Cord entanglement, 030219 obstetrics & reproductive medicine, Obstetrics, Adult, Female, Fetal Death, Humans, Infant, Newborn, Inpatients, Length of Stay, Live Birth, Perinatal Death, Pregnancy, Twin, Prenatal Care, Retrospective Studies, Statistics, Nonparametric, Twins, Monozygotic, Ultrasonography, Prenatal, Perinatal Mortality, Statistics, General Medicine, cesarean delivery, health care, Radiology, medicine.medical_specialty, Socio-culturale, Monozygotic, Multiple Gestation, 03 medical and health sciences, Nonparametric, Radiology, Nuclear Medicine and imaging, business.industry, Infant, Twin, Newborn, Settore MED/40 - Ginecologia e Ostetricia, business, Outpatient management
Abstract

OBJECTIVES: Monoamniotic twin pregnancies are at increased risk of perinatal complications, primarily owing to the risk of cord entanglement. There is no recommendation on whether such pregnancies should be managed in hospital or can be safely managed in an outpatient setting, and the timing of planned delivery is also a subject of debate. The aim of this study was to compare the perinatal outcomes of inpatient vs outpatient fetal surveillance approaches employed among 22 participating study centers, and to calculate the fetal and neonatal death rates according to gestational age, in non-anomalous monoamniotic twins from 26 weeks' gestation. METHODS: The MONOMONO study was a multinational cohort study of consecutive women with monochorionic monoamniotic twin pregnancies, who were referred to 22 university hospitals in Italy, the USA, the UK and Spain, from January 2010 to January 2017. Only non-anomalous uncomplicated monoamniotic twin pregnancies with two live fetuses at 26 + 0 weeks' gestation were included in the study. In 10 of the centers, monoamniotic twins were managed routinely as inpatients, whereas in the other 12 centers they were managed routinely as outpatients. The primary outcome was intrauterine fetal death. We also planned to assess fetal and neonatal death rates according to gestational age per 1-week interval. Outcomes are presented as odds ratio (OR) with 95% CIs. The main outcome was analyzed using both standard logistic regression analysis, in which each fetus was treated as an independent unit, and a generalized mixed-model approach, with each twin pair treated as a cluster unit, considering that the outcome for a twin is not independent of that of its cotwin. RESULTS: 195 consecutive pregnant women with a non-anomalous uncomplicated monoamniotic twin gestation (390 fetuses) were included. Of these, 75 (38.5%) were managed as inpatients and 120 (61.5%) as outpatients. The overall perinatal loss rate was 10.8% (42/390) with a peak fetal death rate of 4.3% (15/348) occurring at 29 weeks' gestation. There was no significant difference in mean gestational age at delivery (31 weeks), birth weight (∼1.6 kg), or emergency delivery rate between the inpatient and outpatient surveillance groups. Based on generalized mixed-model analysis, there was no statistically significant difference in fetal death rates between inpatient management commencing from around 26 weeks compared with outpatient surveillance protocols from 30 weeks (3.3% vs 10.8%; adjusted OR 0.21 (95% CI, 0.04-1.17)). Maternal length of stay in the hospital was 42.1 days in the inpatient group, and 7.4 days in the outpatient group (mean difference 34.70 days (95% CI, 31.36-38.04 days). From 32 + 0 to 36 + 6 weeks, no fetal or neonatal death in either group was recorded. 46 fetuses were delivered after 34 + 0 weeks, and none of them died in utero or within the first 28 days postpartum. CONCLUSION: In uncomplicated monoamniotic twins, inpatient surveillance is associated with similar fetal mortality as outpatient management. After 31 + 6 weeks, and up to 36 + 6 weeks, there were no intrauterine fetal deaths or neonatal deaths. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Published
2018

48. Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology

Author

Cahill, Lindsay S., primary, Stortz, Greg, additional, Ravi Chandran, Anjana, additional, Milligan, Natasha, additional, Shinar, Shiri, additional, Whitehead, Clare L., additional, Hobson, Sebastian R., additional, Ayyathurai, Viji, additional, Rahman, Anum, additional, Saghian, Rojan, additional, Jobst, Karl J., additional, McShane, Cyrethia, additional, Block-Abraham, Dana, additional, Seravalli, Viola, additional, Laurie, Melissa, additional, Millard, Sarah, additional, Delp, Cassandra, additional, Wolfson, Denise, additional, Baschat, Ahmet A., additional, Murphy, Kellie E., additional, Serghides, Lena, additional, Morgen, Eric, additional, Macgowan, Christopher K., additional, Parks, W.Tony, additional, Kingdom, John C., additional, and Sled, John G., additional

Published
2021
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