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4. MO-0381 (A)symptomatic MRI changes after proton therapy; the Dutch national cohort of pediatric CNS tumors

Author

Rutgers, J., primary, Bannink-Gawryszuk, A., additional, van Rossum, P., additional, Lequin, M., additional, Maduro, J., additional, van der Weide, H., additional, Heesters, M., additional, Hoeben, B., additional, van der Heide, A., additional, Plasschaert, S., additional, Gidding, C., additional, de Vos-Kerkhof, E., additional, Meijer, L., additional, van der Lugt, J., additional, Schouten- van Meeteren, A., additional, Matysiak, W., additional, Seravalli, E., additional, Langendijk, H., additional, Hoving, E., additional, and Janssens, G., additional

Published
2023
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8. MO-0713 Stereotactic Body Radiotherapy for Long Bone Metastases: An International Multicenter Analysis

Author

Madani, I., primary, Guckenberger, M., additional, Erler, D., additional, Stish, B.J., additional, Olivier, K.R., additional, Park, S.S., additional, Eppinga, W., additional, Seravalli, E., additional, Redmond, K.J., additional, Cao, Y., additional, Siva, S., additional, Chang, D., additional, Nguyen, T.K., additional, O’Neil, M., additional, and Sahgal, A., additional

Published
2022
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9. Dosimetric feasibility of direct post-operative MR-Linac-based stereotactic radiosurgery for resection cavities of brain metastases

Author

Sierts, M., Seravalli, E., Brand, E., Matteo Maspero, David, S., Philippens, M. E. P., Voormolen, E. H. J., and Verhoeff, J. J. C.

Subjects
Oncology, Radiology, Nuclear Medicine and imaging, Hematology
Abstract

Post-operative radiosurgery (SRS) of brain metastases patients is typically planned on a post-recovery MRI, 2-4 weeks after resection. However, the intracranial metastasis may (re-)grow in this period. Planning SRS directly on the post-operative MRI enables shortening this time interval, anticipating the start of adjuvant systemic therapy, and so decreasing the chance of extracranial progression. The MRI-Linac (MRL) allows the simultaneous execution of the post-operative MRI and SRS treatment. The aim of this work was investigating the dosimetric feasibility of MRL-based post-operative SRS.MRL treatments based on the direct post-operative MRI were simulated, including thirteen patients with resectable single brain metastases. The gross tumor volume (GTV) was contoured on the direct post-operative scans and compared to the post-recovery MRI GTV. Three plans for each patient were created: a non-coplanar VMAT CT-Linac plan (ncVMAT) and a coplanar IMRT MRL plan (cIMRT) on the direct post-operative MRI, and a ncVMAT plan on the post-recovery MRI as the current clinical standard.Between the direct post-operative and post-recovery MRI, 15.5 % of the cavities shrunk by 2 cc, and 46 % expanded by ≥ 2 cc. Although the direct post-operative cIMRT plans had a higher median gradient index (3.6 vs 2.7) and median V3Gy of the skin (18.4 vs 1.1 cc) compared to ncVMAT plans, they were clinically acceptable.Direct post-operative MRL-based SRS for resection cavities of brain metastases is dosimetrically acceptable, with the advantages of increased patient comfort and logistics. Clinical benefit of this workflow should be investigated given the dosimetric plausibility.

Published
2023

12. Locoregional Control Using Highly Conformal Flank Target Volumes and Volumetric-Modulated Arc Therapy in Pediatric Renal Tumors: Results from the Dutch National Cohort

Author

Hubrecht Institute with UMC, PMC Medisch specialisten, Klinische Fysica RT, Cancer, MS Radiotherapie, Onderzoek Beeld, NEMI, Zorgeenheid Kinderchirurgie Medisch, Pathologie Pathologen staf, MS Radiologie, Speerpunt, Zorg en O&O, Child Health, Mul, J., Van Grotel, M., Seravalli, E., Bosman, M., Van Tinteren, H., Roy, P., Fajardo, R. Davila, Tytgat, L., Mavinkurve-Groothuis, A., Van De Ven, C., Wijnen, M., De Krijger, R., Littooij, A., Van den Heuvel-Eibrink, M., Janssens, G., Hubrecht Institute with UMC, PMC Medisch specialisten, Klinische Fysica RT, Cancer, MS Radiotherapie, Onderzoek Beeld, NEMI, Zorgeenheid Kinderchirurgie Medisch, Pathologie Pathologen staf, MS Radiologie, Speerpunt, Zorg en O&O, Child Health, Mul, J., Van Grotel, M., Seravalli, E., Bosman, M., Van Tinteren, H., Roy, P., Fajardo, R. Davila, Tytgat, L., Mavinkurve-Groothuis, A., Van De Ven, C., Wijnen, M., De Krijger, R., Littooij, A., Van den Heuvel-Eibrink, M., and Janssens, G.

Published
2021

13. Morphological changes after cranial fractionated photon radiotherapy: Localized loss of white matter and grey matter volume with increasing dose

Author

Onderzoek Radiotherapie, Neuropsychologie, ZL Algemene Neurologie Medisch, Klinische Fysica RT, Cancer, Neurologen, Brain, MS Radiotherapie, Nagtegaal, S. H.J., David, S., van Grinsven, E. E., van Zandvoort, M. J.E., Seravalli, E., Snijders, T. J., Philippens, M. E.P., Verhoeff, J. J.C., Onderzoek Radiotherapie, Neuropsychologie, ZL Algemene Neurologie Medisch, Klinische Fysica RT, Cancer, Neurologen, Brain, MS Radiotherapie, Nagtegaal, S. H.J., David, S., van Grinsven, E. E., van Zandvoort, M. J.E., Seravalli, E., Snijders, T. J., Philippens, M. E.P., and Verhoeff, J. J.C.

Published
2021

14. Inter-Clinician Delineation Variation for a New Highly-Conformal Flank Target Volume in Children with Renal Tumors: A Siop-Renal Tumor Study Group International Multicenter Exercise

Author

Hubrecht Institute with UMC, Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Mul, J., Melchior, P., Seravalli, E., Saunders, D., Bolle, S., Cameron, A., Gurtner, K., Harrabi, S., Lassen-Ramshad, Y., Lavan, N., Magelssen, H., Mandeville, H., Boterberg, T., Kroon, P., Kotte, A., Hoeben, B., Van Rossum, P., Van Grotel, M., Graf, N., Van den Heuvel-Eibrink, M., Rube, C., Janssens, G., Hubrecht Institute with UMC, Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Mul, J., Melchior, P., Seravalli, E., Saunders, D., Bolle, S., Cameron, A., Gurtner, K., Harrabi, S., Lassen-Ramshad, Y., Lavan, N., Magelssen, H., Mandeville, H., Boterberg, T., Kroon, P., Kotte, A., Hoeben, B., Van Rossum, P., Van Grotel, M., Graf, N., Van den Heuvel-Eibrink, M., Rube, C., and Janssens, G.

Published
2021

16. Deep learning prediction of proton and photon dose distributions for paediatric abdominal tumours

Author

Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiotherapie, PMC Medisch specialisten, Experimentele klinische fysica, Guerreiro, F, Seravalli, E, Janssens, G O, Maduro, J H, Knopf, A C, Langendijk, J A, Raaymakers, B W, Kontaxis, C, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiotherapie, PMC Medisch specialisten, Experimentele klinische fysica, Guerreiro, F, Seravalli, E, Janssens, G O, Maduro, J H, Knopf, A C, Langendijk, J A, Raaymakers, B W, and Kontaxis, C

Published
2021

19. Current radiotherapy practice for children with metastases from solid tumors : SIOPE survey analysis

Author

Huijskens, S., Kroon, P., Abakay, C. Demiroz, Timmermann, B., Giralt, J., Gaze, M., Harrabi, S., Scarzello, G., Alexopoulou, A., Padovani, L., Escande, A., Gandola, L., Supiot, S., Chojnacka, M., Bokun, J., Napieralska, A., Rombi, B., Maduro, J. H., Bolle, S., Mussano, A., Mandeville, H., Claude, L., Seravalli, E., Janssens, G. O., and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Medizin
Published
2020

25. OC-0454: Current radiotherapy practice for children with metastases from solid tumors: SIOPE survey analysis

Author

Huijskens, S., primary, Kroon, P., additional, Demiroz Abakay, C., additional, Timmermann, B., additional, Giralt, J., additional, Gaze, M., additional, Harrabi, S., additional, Scarzello, G., additional, Alexopoulou, A., additional, Padovani, L., additional, Escande, A., additional, Gandola, L., additional, Supiot, S., additional, Chojnacka, M., additional, Bokun, J., additional, Napieralska, A., additional, Rombi, B., additional, Maduro, J.H., additional, Bolle, S., additional, Mussano, A., additional, Mandeville, H., additional, Claude, L., additional, Seravalli, E., additional, and Janssens, G.O., additional

Published
2020
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26. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group

Author

Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., Janssens, G.O., Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., and Janssens, G.O.

Abstract

Item does not contain fulltext, Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy.

Published
2019

29. Sparing the surgical area with stereotactic body radiotherapy for combined treatment of spinal metastases: a treatment planning study

Author

Trialbureau Beeld, Other research (not in main researchprogram), Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, MS Orthopaedie Spine, Regenerative Medicine and Stem Cells, Klinische Fysica RT, Orthopaedie Opleiding, Versteeg, A L, Hes, J, van der Velden, J M, Eppinga, W, Kasperts, N, Verkooijen, H M, van Vulpen, M, Oner, F C, Seravalli, E, Verlaan, J J, Trialbureau Beeld, Other research (not in main researchprogram), Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, MS Orthopaedie Spine, Regenerative Medicine and Stem Cells, Klinische Fysica RT, Orthopaedie Opleiding, Versteeg, A L, Hes, J, van der Velden, J M, Eppinga, W, Kasperts, N, Verkooijen, H M, van Vulpen, M, Oner, F C, Seravalli, E, and Verlaan, J J

Published
2019

30. Potential benefit of MRI-guided IMRT for flank irradiation in pediatric patients with Wilms' tumor

Author

Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Fysica Radiotherapie Research, Guerreiro, F, Seravalli, E, Janssens, G O, van den Heuvel-Eibrink, M M, Lagendijk, J J W, Raaymakers, B W, Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Fysica Radiotherapie Research, Guerreiro, F, Seravalli, E, Janssens, G O, van den Heuvel-Eibrink, M M, Lagendijk, J J W, and Raaymakers, B W

Published
2019

35. Auditing local methods for quality assurance in radiotherapy using the same set of predefined treatment plans

Author

Seravalli, E., Houweling, A.C. (Arjan), Van Battum, L., Raaben, T.A., Kuik, M., Pooter, J.A. (Jacobus Abraham) de, Van Gellekom, M.P.R., Kaas, J., de Vries, W., Loeff, E.A., Van de Kamer, J.B., Seravalli, E., Houweling, A.C. (Arjan), Van Battum, L., Raaben, T.A., Kuik, M., Pooter, J.A. (Jacobus Abraham) de, Van Gellekom, M.P.R., Kaas, J., de Vries, W., Loeff, E.A., and Van de Kamer, J.B.

Abstract

Background and purpose: Local implementation of plan-specific quality assurance (QA) methods for intensitymodulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) treatment plans may vary because of dissimilarities in procedures, equipment and software. The purpose of this work is detecting possible differences between local QA findings and those of an audit, using the same set of treatment plans. Methods: A pre-defined set of clinical plans was devised and imported in the participating institute’s treatment planning system for dose computation. The dose distribution was measured using an ionisation chamber, radiochromic film and an ionisation chamber array. The centres performed their own QA, which was compared to the audit findings. The agreement/disagreement between the audit and the institute QA results were assessed along with the differences between the dose distributions measured by the audit team and computed by the institute. Results: For the majority of the cases the results of the audit were in agreement with the institute QA findings: ionisation chamber: 92%, array: 88%, film: 76% of the total measurements. In only a few of these cases the evaluated measurements failed for both: ionisation chamber: 2%, array: 4%, film: 0% of the total measurements. Conclusion: Using predefined treatment plans, we found that in approximately 80% of the evaluated measurements the results of local QA of IMRT and VMAT plans were in line with the findings of the audit. However, the percentage of agreement/disagreement depend

Published
2018
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36. Inter-observer agreement in GTV delineation of bone metastases on CT and impact of MR imaging : A multicenter study

Author

Gerlich, A. S., van der Velden, J. M., Kotte, A. N.T.J., Tseng, C. L., Fanetti, G., Eppinga, W. S.C., Kasperts, N., Intven, M. P.W., Pameijer, F. A., Philippens, M. E.P., Verkooijen, H. M., Seravalli, E., Gerlich, A. S., van der Velden, J. M., Kotte, A. N.T.J., Tseng, C. L., Fanetti, G., Eppinga, W. S.C., Kasperts, N., Intven, M. P.W., Pameijer, F. A., Philippens, M. E.P., Verkooijen, H. M., and Seravalli, E.

Published
2018

37. Inter-observer agreement in GTV delineation of bone metastases on CT and impact of MR imaging: A multicenter study

Author

Onderzoek Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Klinische Fysica RT, MS Radiotherapie, MS Radiologie, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Gerlich, A. S., van der Velden, J. M., Kotte, A. N.T.J., Tseng, C. L., Fanetti, G., Eppinga, W. S.C., Kasperts, N., Intven, M. P.W., Pameijer, F. A., Philippens, M. E.P., Verkooijen, H. M., Seravalli, E., Onderzoek Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Klinische Fysica RT, MS Radiotherapie, MS Radiologie, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Gerlich, A. S., van der Velden, J. M., Kotte, A. N.T.J., Tseng, C. L., Fanetti, G., Eppinga, W. S.C., Kasperts, N., Intven, M. P.W., Pameijer, F. A., Philippens, M. E.P., Verkooijen, H. M., and Seravalli, E.

Published
2018

43. EP-2144: Tumor and OAR delineation variation – Dice coefficient versus dose assessed with automated planning

Author

Habraken, S.J.M., primary, Sharfo, A.W.M., additional, Buijsen, J., additional, Verbakel, W.F.A.R., additional, Haasbeek, C.J.A., additional, Ollers, M.C., additional, Westerveld, G.H., additional, Van Wieringen, N., additional, Reerink, O., additional, Seravalli, E., additional, Braam, P.M., additional, Wendling, M., additional, Lacornerie, T., additional, Mirabel, X., additional, Weytjens, R., additional, Depuydt, L., additional, Tanadini-Lang, S., additional, Riesterer, O., additional, Haustermans, K., additional, Depuydt, T., additional, Dwarkasing, R.S., additional, Willemssen, F.E.J.A., additional, Heijmen, B.J.M., additional, and Méndez Romero, A., additional

Published
2018
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45. The TRENDY multi-center randomized trial on hepatocellular carcinoma - Trial QA including automated treatment planning and benchmark-case results

Author

Habraken, S.J.M., Sharfo, A.W.M., Buijsen, J., Verbakel, W., Haasbeek, C.J.A., Ollers, M.C., Westerveld, H., Wieringen, N. van, Reerink, O., Seravalli, E., Braam, P.M., Wendling, M., Lacornerie, T., Mirabel, X., Weytjens, R., Depuydt, L., Tanadini-Lang, S., Riesterer, O., Haustermans, K., Depuydt, T., Dwarkasing, R.S., Willemssen, F., Heijmen, B.J.M., Romero, A., Habraken, S.J.M., Sharfo, A.W.M., Buijsen, J., Verbakel, W., Haasbeek, C.J.A., Ollers, M.C., Westerveld, H., Wieringen, N. van, Reerink, O., Seravalli, E., Braam, P.M., Wendling, M., Lacornerie, T., Mirabel, X., Weytjens, R., Depuydt, L., Tanadini-Lang, S., Riesterer, O., Haustermans, K., Depuydt, T., Dwarkasing, R.S., Willemssen, F., Heijmen, B.J.M., and Romero, A.

Abstract

Item does not contain fulltext, BACKGROUND AND PURPOSE: The TRENDY trial is an international multi-center phase-II study, randomizing hepatocellular carcinoma (HCC) patients between transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) with a target dose of 48-54Gy in six fractions. The radiotherapy quality assurance (QA) program, including prospective plan feedback based on automated treatment planning, is described and results are reported. MATERIALS AND METHODS: Scans of a single patient were used as a benchmark case. Contours submitted by nine participating centers were compared with reference contours. The subsequent planning round was based on a single set of contours. A total of 20 plans from participating centers, including 12 from the benchmark case, 5 from a clinical pilot and 3 from the first study patients, were compared to automatically generated VMAT plans. RESULTS: For the submitted liver contours, Dice Similarity Coefficients (DSC) with the reference delineation ranged from 0.925 to 0.954. For the GTV, the DSC varied between 0.721 and 0.876. For the 12 plans on the benchmark case, healthy liver normal-tissue complication probabilities (NTCPs) ranged from 0.2% to 22.2% with little correlation between NCTP and PTV-D95% (R(2)<0.3). Four protocol deviations were detected in the set of 20 treatment plans. Comparison with co-planar autoVMAT QA plans revealed these were due to too high target dose and suboptimal planning. Overall, autoVMAT resulted in an average liver NTCP reduction of 2.2 percent point (range: 16.2 percent point to -1.8 percent point, p=0.03), and lower doses to the healthy liver (p<0.01) and gastrointestinal organs at risk (p<0.001). CONCLUSIONS: Delineation variation resulted in feedback to participating centers. Automated treatment planning can play an important role in clinical trials for prospective plan QA as suboptimal plans were detected.

Published
2017

46. OC-0541: Automated treatment planning for prospective QA in the TRENDY randomized trial on liver-SBRT for HCC

Author

Habraken, S.J.M., primary, Sharfo, A.W., additional, Buijsen, J., additional, Verbakel, W.F.A.R., additional, Haasbeek, C.J.A., additional, Ollers, M.C., additional, Westerveld, G.H., additional, Van Wieringen, N., additional, Reerink, O., additional, Seravalli, E., additional, Braam, P.M., additional, Wendling, M., additional, Lacornerie, T., additional, Mirabel, X., additional, Weytjens, R., additional, Depuydt, L., additional, Lang, S., additional, Riesterer, O., additional, Haustermans, K., additional, Depuydt, T., additional, Heijmen, B.J.M., additional, and Méndez Romero, A., additional

Published
2017
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