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1. Physical capacity in performing daily activities is reduced in scleroderma patients with early lung involvement

Author

Salvatore, Battaglia, Maria, Bellia, Laura, Serafino-Agrusa, Annarita, Giardina, Maria, Messina, Fabio, Cannizzaro, Massimo, Midiri, Giovanni, Triolo, Nicola, Scichilone, Battaglia, S., Bellia, M., Serafino-Agrusa, L., Giardina, A., Messina, M., Cannizzaro, F., Midiri, M., Triolo, G., and Scichilone, N.

Subjects
Adult, Male, Scleroderma, Systemic, Physical activity, Hypertension, Pulmonary, Middle Aged, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Lung function, Scleroderma, Nutrition Assessment, Spirometry, Activities of Daily Living, Humans, Motion sensor, Female, Exercise, Aged
Abstract

BACKGROUND: Patients with systemic sclerosis (SSc) often complain reduced capacity at submaximal exercise; conversely physical capacity in performing daily duties has never been measured in SSc. OBJECTIVES: To evaluate this performance and its correlates, in patients with SSc compared to healthy controls, in a free-living setting. METHODS: Twenty-seven outpatients with stable SSc and 11 controls were recruited. Physical activity was assessed by portable multiple sensor device (SenseWear Armband) worn for at least six days. Physical activity duration (PAD; in minutes) for non-sedentary activities and physical activity level (PAL= total daily energy/resting energy expenditure) per day were calculated. Nutritional status was estimated by bioelectrical impedance analysis, and pulmonary arterial hyperthension excluded by echocardiography. RESULTS: Daily physical activities (243+/-145 minutes per day versus 397+/-142 min, respectively; p=0.005) and PAL were significantly reduced in SSc compared to controls (1.5+/-0.4 vs 2+/-0.7, respectively; p=0.019). 74% of SSc patients showed PAL

Published
2017

2. Asthma and metabolic syndrome: Current knowledge and future perspectives

Author

Laura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone, Serafino Agrusa, L, Spatafora, M, and Scichilone, N.

Subjects
business.industry, Minireviews, Context (language use), General Medicine, Settore MED/10 - Malattie Dell'Apparato Respiratorio, medicine.disease, Bioinformatics, Obesity, Atopy, Insulin resistance, medicine, Hyperinsulinemia, asthma, obesity, Metabolic syndrome, business, Dyslipidemia, Asthma
Abstract

Asthma and obesity are epidemiologically linked; however, similar relationships are also observed with other markers of the metabolic syndrome, such as insulin resistance and dyslipidemia, which cannot be accounted for by increased body mass alone. Obesity appears to be a predisposing factor for the asthma onset, both in adults and in children. In addition, obesity could make asthma more difficult to control and to treat. Although obesity may predispose to increased Th2 inflammation or tendency to atopy, other mechanisms need to be considered, such as those mediated by hyperglycaemia, hyperinsulinemia and dyslipidemia in the context of metabolic syndrome. The mechanisms underlying the association between asthma and metabolic syndrome are yet to be determined. In the past, these two conditions were believed to occur in the same individual without any pathogenetic link. However, the improvement in asthma symptoms following weight reduction indicates a causal relationship. The interplay between these two diseases is probably due to a bidirectional interaction. The purpose of this review is to describe the current knowledge about the possible link between metabolic syndrome and asthma, and explore potential application for future studies and strategic approaches.

Published
2015
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3. Fever and dyspnoea in a tracheostomised patient.

Author

Arena C, Scaduto F, Principe S, Benfante A, Messina R, La Sala A, Serafino Agrusa L, Martorana A, Cabibi D, Solidoro P, and Scichilone N

Abstract

Pneumonia of unknown origin in tracheostomised patient https://bit.ly/3hZHBA0., Competing Interests: Conflict of interest: C. Arena has nothing to disclose. Conflict of interest: F. Scaduto has nothing to disclose. Conflict of interest: S. Principe has nothing to disclose. Conflict of interest: A. Benfante has nothing to disclose. Conflict of interest: R. Messina has nothing to disclose. Conflict of interest: A. La Sala has nothing to disclose. Conflict of interest: L. Serafino Agrusa has nothing to disclose. Conflict of interest: A. Martorana has nothing to disclose. Conflict of interest: D. Cabibi has nothing to disclose. Conflict of interest: P. Solidoro has nothing to disclose. Conflict of interest: N. Scichilone has nothing to disclose., (Copyright ©ERS 2020.)

Published
2020
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4. Physical capacity in performing daily activities is reduced in scleroderma patients with early lung involvement.

Author

Battaglia S, Bellia M, Serafino-Agrusa L, Giardina A, Messina M, Cannizzaro F, Midiri M, Triolo G, and Scichilone N

Subjects
Activities of Daily Living, Adult, Aged, Exercise, Female, Humans, Male, Middle Aged, Nutrition Assessment, Spirometry, Hypertension, Pulmonary physiopathology, Scleroderma, Systemic physiopathology
Abstract

Background and Aims: Patients with systemic sclerosis (SSc) often complain reduced capacity at submaximal exercise; conversely, physical capacity in performing daily duties has never been measured in SSc. The aim of this study is to evaluate this performance and its correlates, in patients with SSc compared with healthy controls, in a free-living setting., Methods: Twenty-seven outpatients with stable SSc and 11 controls were recruited. Physical activity was assessed by portable multiple sensor device (SenseWear Armband) worn for at least 6 days. Physical activity duration (PAD; in minutes) for non-sedentary activities and physical activity level (PAL = total daily energy/resting energy expenditure) per day were calculated. Nutritional status was estimated by bioelectrical impedance analysis and pulmonary arterial hypertension excluded by echocardiography., Results: Daily physical activities (243 ± 145 min per day vs 397 ± 142 min, respectively; P = 0.005) and PAL were significantly reduced in SSc compared with controls (1.5 ± 0.4 vs 2 ± 0.7, respectively; P = 0.019). Seventy-four per cent of SSc patients showed PAL < 1.70, whereas only 27% of controls were below this threshold for sedentary life style. Both PAD and PAL positively correlated with DLco. Patients and controls did not differ for spirometric parameters, body mass index, phase angle at bioelectrical impedance analysis, fat mass or fat-free mass indexes. In SSc, exercise capacity during daily activity was reduced compared with controls, and was associated with early evidence of functional decay (decreasing DLco) but not with malnutrition (undernutrition)., Conclusions: A reduction of daily physical activity is already present even in early stages of lung involvement in SSc, characterized by unaltered spirometry and well-preserved nutritional status., (© 2015 John Wiley & Sons Ltd.)

Published
2017
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5. Blood eosinophils and treatment response in hospitalized exacerbations of chronic obstructive pulmonary disease: A case-control study.

Author

Serafino-Agrusa L, Scichilone N, Spatafora M, and Battaglia S

Subjects
Adrenal Cortex Hormones administration & dosage, Aged, Aged, 80 and over, Case-Control Studies, Female, Hospitalization, Humans, Length of Stay, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive physiopathology, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Adrenal Cortex Hormones therapeutic use, Eosinophilia epidemiology, Eosinophils metabolism, Pulmonary Disease, Chronic Obstructive drug therapy
Abstract

Background: In outpatients with chronic obstructive pulmonary disease (COPD), blood eosinophilia is considered as a biomarker of response to systemic corticosteroid therapy. However, little is known on whether blood eosinophilia is also predictive of positive clinical outcome in severe acute exacerbations of COPD requiring hospitalization. We hypothesized that blood eosinophil-positive severe acute exacerbations of COPD differ from eosinophil-negative ones in terms of response to therapy and clinical outcomes., Methods: To test our experimental hypothesis, we retrospectively analyzed medical records of patients with COPD admitted to our ward because of severe exacerbation, over a two-year period of observation. After evaluation of inclusion and exclusion criteria, 132 patients were selected and divided in cases (blood eosinophilia ≥2% at admission; n = 20) and controls (blood eosinophilia <2% at admission; n = 112)., Results: Cases had a shorter hospital stay than controls (geometric mean = 8.9 ± 1.5 versus 11.3 ± 1.5 days; p = 0.028). In addition, cases had a significantly lower consumption of systemic corticosteroids (geometric mean = 19.2 ± 4.0 versus 35.7 ± 2.5 mg per day of hospitalization; p = 0.012)., Conclusions: In severe acute exacerbations of COPD requiring hospitalization, blood eosinophilia identifies a subgroup of subjects characterized by a prompt response to treatment with shorter hospital stay., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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