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131 results on '"Sepulveda, Nuno"'

3. Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Author

Steiner, Sophie, Fehrer, Annick, Hoheisel, Friederike, Schoening, Simon, Aschenbrenner, Anna, Babel, Nina, Bellmann-Strobl, Judith, Finke, Carsten, Fluge, Øystein, Froehlich, Laura, Goebel, Andreas, Grande, Bettina, Haas, Johannes-Peter, Hohberger, Bettina, Jason, Leonard A., Komaroff, Anthony L., Lacerda, Eliana, Liebl, Max, Maier, Andrea, Mella, Olav, Nacul, Luis, Paul, Friedemann, Prusty, Bhupesh K., Puta, Christian, Riemekasten, Gabriela, Ries, Wolfgang, Rowe, Peter C., Sawitzki, Birgit, Shoenfeld, Yehuda, Schultze, Joachim L., Seifert, Martina, Sepúlveda, Nuno, Sotzny, Franziska, Stein, Elisa, Stingl, Michael, Ufer, Friederike, Veauthier, Christian, Westermeier, Francisco, Wirth, Klaus, Wolfarth, Bernd, Zalewski, Pawel, Behrends, Uta, and Scheibenbogen, Carmen

Published
2023
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10. Failure of rapid diagnostic tests in Plasmodium falciparum malaria cases among travelers to the UK and Ireland: Identification and characterisation of the parasites

Author

Nolder, Debbie, Stewart, Lindsay, Tucker, Julie, Ibrahim, Amy, Gray, Adam, Corrah, Tumena, Gallagher, Carmel, John, Laurence, O’Brien, Edel, Aggarwal, Dinesh, Benavente, Ernest Diez, van Schalkwyk, Donelly, Henriques, Gisela, Sepúlveda, Nuno, Campino, Susana, Chiodini, Peter, Sutherland, Colin, and Beshir, Khalid B.

Published
2021
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12. Association between the proportion of Plasmodium falciparum and Plasmodium vivax infections detected by passive surveillance and the magnitude of the asymptomatic reservoir in the community: a pooled analysis of paired health facility and community data

Author

Stresman, Gillian, Sepúlveda, Nuno, Fornace, Kimberly, Grignard, Lynn, Mwesigwa, Julia, Achan, Jane, Miller, John, Bridges, Daniel J, Eisele, Thomas P, Mosha, Jacklin, Lorenzo, Pauline Joy, Macalinao, Maria Lourdes, Espino, Fe Esperanza, Tadesse, Fitsum, Stevenson, Jennifer C, Quispe, Antonio M, Siqueira, André, Lacerda, Marcus, Yeung, Shunmay, Sovannaroth, Siv, Pothin, Emilie, Gallay, Joanna, Hamre, Karen E, Young, Alyssa, Lemoine, Jean Frantz, Chang, Michelle A, Phommasone, Koukeo, Mayxay, Mayfong, Landier, Jordi, Parker, Daniel M, Von Seidlein, Lorenz, Nosten, Francois, Delmas, Gilles, Dondorp, Arjen, Cameron, Ewan, Battle, Katherine, Bousema, Teun, Gething, Peter, D'Alessandro, Umberto, and Drakeley, Chris

Published
2020
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13. A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

Author

Grignard, Lynn, Nolder, Debbie, Sepúlveda, Nuno, Berhane, Araia, Mihreteab, Selam, Kaaya, Robert, Phelan, Jody, Moser, Kara, van Schalkwyk, Donelly A., Campino, Susana, Parr, Jonathan B., Juliano, Jonathan J., Chiodini, Peter, Cunningham, Jane, Sutherland, Colin J., Drakeley, Chris, and Beshir, Khalid B.

Published
2020
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16. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
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31. Corrigendum to ‘A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections’

Author

Grignard, Lynn, Nolder, Debbie, Sepulveda, Nuno, Berhane, Araia, Mihreteab, Selam, Kaaya, Robert, Phelan, Jody, Moser, Kara, van Schalkwyk, Donelly A., Campino, Susana, Parr, Jonathan B., Juliano, Jonathan J., Chiodini, Peter, Cunningham, Jane, Sutherland, Colin J., Drakeley, Chris, and Beshir, Khalid B.

Published
2021
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33. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) : Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe

Author

Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid Bergliot, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Estévez-López, Fernando, Zalewski, Paweł, Pheby, Derek, Castro-Marrero, Jesús, Sakkas, Giorgos K., Capelli, Enrica, Brundsdlund, Ivan, Cullinan, John, Krumina, Angelika, Bergquist, Jonas, Murovska, Modra, Vermuelen, Ruud C. W., Lacerda, Eliana, Universitat Autònoma de Barcelona, Child and Adolescent Psychiatry / Psychology, Institut Català de la Salut, [Nacul L] London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London WC1E 7HT, UK. BC Women’s Hospital, Vancouver, BC V6H 3N1, Canada. [Authier FJ] Faculty of Medicine Créteil—Paris Est, 94010 Creteil, France. [Scheibenbogen C] Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. [Lorusso L] Neurology and Stroke Unit—Neuroscience Department—A.S.S.T.—Lecco, 23900 Merate, Italy. [Helland IB] National Advisory Unit on CFS/ME, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway. [Martin JA] Unitat de Fatiga Crònica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castro-Marrero J] Secció de Reumatologia, Unitat de Recerca en Síndrome de Fatiga Crònica / Encefalomielitis Miàlgica (SFC/EM), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Chronic Fatigue Syndrome, Medicine (General), diagnosis, Service provision, Encephalomyelitis, Care, Malalties - Presa de decisions, Health services, 0302 clinical medicine, Health care, Diagnosis, Other subheadings::/diagnosis [Other subheadings], 030212 general & internal medicine, health care economics and organizations, Fatigue Syndrome, Chronic, General Medicine, Psychological Phenomena::Mental Processes::Thinking::Decision Making::Consensus [PSYCHIATRY AND PSYCHOLOGY], ddc, Europe, Nervous System Diseases::Central Nervous System Diseases::Encephalomyelitis::Nervous System Diseases::Fatigue Syndrome, Chronic [DISEASES], localizaciones geográficas::Europa (continente) [DENOMINACIONES GEOGRÁFICAS], fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión::consenso [PSIQUIATRÍA Y PSICOLOGÍA], Myalgic Encephalomyelitis, Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi, musculoskeletal diseases, medicine.medical_specialty, Opinion, Consensus, Otros calificadores::/diagnóstico [Otros calificadores], Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Geographic Locations::Europe [GEOGRAPHICALS], Síndrome de fatiga crònica - Diagnòstic - Europa, 03 medical and health sciences, R5-920, medicine, Chronic fatigue syndrome, Humans, care, health services, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::encefalomielitis::enfermedades del sistema nervioso::síndrome de fatiga crónica [ENFERMEDADES], business.industry, Network on, Expert consensus, Health Care Service and Management, Health Policy and Services and Health Economy, medicine.disease, Family medicine, Clinical diagnosis, business, Delivery of Health Care, 030217 neurology & neurosurgery
Abstract

Encefalomielitis miàlgica/síndrome de fatiga crònica; Cura; Diagnòstic Myalgic encephalomyelitis/chronic fatigue syndrome; Care; Diagnosis Encefalomielitis miálgica/síndrome de fatiga crónica; Cuidado; Diagnóstico Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)—COST action 15111—from 2016 to 2020. The main goal of the Cost Action was to assess the existing knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report our findings and make recommendations for clinical diagnosis, health services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS. This research received no external funding. EUROMENE receives funding for networking activities from the COST programme (COST Action 15111), via the COST Association.

Published
2021
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34. EUROPEAN ME NETWORK (EUROMENE) Expert Consensus on the Diagnosis, Service Provision and Care of People with ME/CFS in Europe

Author

Nacul, Luis, Authier, Jerome, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Lopez, Fernando Esteves, Zalewsk, Pawel, Pheby, Derek, Castro-Marrero, Jesus, Sakkas, Giorgos, Bergquist, Jonas, Capelli, Enrica, Brandslund, Ivan, Cullinan, John, Krumina, Angelika, Murovska, Modra, Vermuelen, Ruud, and Lacerda, Eliana

Subjects
musculoskeletal diseases, allergology, clinical_neurology, health care economics and organizations
Abstract

Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation is Science and Technology (COST) (https://www.cost.eu/cost-actions/what-are-cost-actions/ ) - COST action 15111 - from 2016 to 2020. The main goal of the Cost Action was to assess the existing fragmented knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report on the recommendations for clinical diagnosis, heath services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS (https://www.cost.eu/actions/CA15111/#tabs|Name:overview).

Published
2020

35. G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials

Author

Sepulveda, Nuno, Grignard, Lynn, Curry, Jonathan, Mahey, Laleta, Bastiaens, G.J.H., Tiono, A.B., Lanke, K.H., Bousema, T., Drakeley, C., Sepulveda, Nuno, Grignard, Lynn, Curry, Jonathan, Mahey, Laleta, Bastiaens, G.J.H., Tiono, A.B., Lanke, K.H., Bousema, T., and Drakeley, C.

Abstract

Contains fulltext : 232901.pdf (Publisher’s version ) (Open Access)

Published
2021

36. Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Author

Stanculescu, Dominic, Sepulveda, Nuno, Lim, Chin Leong, Bergquist, Jonas, Stanculescu, Dominic, Sepulveda, Nuno, Lim, Chin Leong, and Bergquist, Jonas

Abstract

We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transcriptomic studies suggest that similar gene expressions are altered in both heat stroke and ME/CFS. Finally, some predisposing factors for heat stroke, such as pre-existing inflammation or infection, overlap with those for ME/CFS. Notwithstanding important differences - and despite heat stroke being an acute condition - the overlaps between heat stroke and ME/CFS suggest common pathways in the physiological responses to very different forms of stressors, which are manifested in different clinical outcomes. The human studies and animal models of heat stroke provide an explanation for the self-perpetuation of homeostatic imbalance centered around intestinal wall injury, which could also inform the understanding of ME/CFS. Moreover, the studies of novel therapeutics for heat stroke might provide new avenues for the treatment of ME/CFS. Future research should be conducted to investigate the similarities between heat stroke and ME/CFS to help identify the potential treatments for ME/CFS.

Published
2021
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37. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE):Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe

Author

Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid Bergliot, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Estévez-López, Fernando, Zalewski, Pawel, Pheby, Derek F.H., Castro-Marrero, Jesus, Sakkas, Giorgos K., Capelli, Enrica, Brundsdlund, Ivan, Cullinan, John, Krumina, Angelika, Bergquist, Jonas, Murovska, Modra, Vermuelen, Ruud C.W., Lacerda, Eliana M., Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid Bergliot, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Estévez-López, Fernando, Zalewski, Pawel, Pheby, Derek F.H., Castro-Marrero, Jesus, Sakkas, Giorgos K., Capelli, Enrica, Brundsdlund, Ivan, Cullinan, John, Krumina, Angelika, Bergquist, Jonas, Murovska, Modra, Vermuelen, Ruud C.W., and Lacerda, Eliana M.

Abstract

Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)-COST action 15111-from 2016 to 2020. The main goal of the Cost Action was to assess the existing knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report our findings and make recommendations for clinical diagnosis, health services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS.

Published
2021

38. Recommendations for Epidemiological Research in ME/CFS from the EUROMENE Epidemiology Working Group

Author

Mudie, Kathleen, primary, Estévez-López, Fernando, additional, Sekulic, Slobodan, additional, Ivanovs, Andrejs, additional, Sepulveda, Nuno, additional, Zalewski, Pawel, additional, Mengshoel, Anne Marit, additional, De Korwin, Jean-Dominique, additional, Hinic Capo, Natasa, additional, Alegre-Martin, Jose, additional, Castro-Marrero, Jesus, additional, Murovska, Modra, additional, Nacul, Luis, additional, and Lacerda, Eliana, additional

Published
2020
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40. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Author

Surendran, Praveen, Feofanova, Elena V., Lahrouchi, Najim, Ntalla, Ioanna, Karthikeyan, Savita, Cook, James, Chen, Lingyan, Mifsud, Borbala, Yao, Chen, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Thorleifsson, Gudmar, Liu, Dajiang J., Prins, Bram P., Stewart, Isobel D., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Auer, Paul L., Bielak, Lawrence F., Bis, Joshua C., Braithwaite, Vickie S., Brody, Jennifer A., Daw, E. Warwick, Warren, Helen R., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Fauman, Eric B., Fava, Cristiano, Ferreira, Teresa, Foley, Christopher N., Franceschini, Nora, Gao, He, Giannakopoulou, Olga, Giulianini, Franco, Gudbjartsson, Daniel F., Guo, Xiuqing, Harris, Sarah E., Havulinna, Aki S., Helgadottir, Anna, Huffman, Jennifer E., Hwang, Shih-Jen, Kanoni, Stavroula, Kontto, Jukka, Larson, Martin G., Li-Gao, Ruifang, Lindstrom, Jaana, Lotta, Luca A., Lu, Yingchang, Luan, Jian'an, Mahajan, Anubha, Malerba, Giovanni, Masca, Nicholas G. D., Mei, Hao, Menni, Cristina, Mook-Kanamori, Dennis O., Mosen-Ansorena, David, Muller-Nurasyid, Martina, Pare, Guillaume, Paul, Dirk S., Perola, Markus, Poveda, Alaitz, Rauramaa, Rainer, Richard, Melissa, Richardson, Tom G., Sepulveda, Nuno, Sim, Xueling, Smith, Albert, V, Smith, Jennifer A., Staley, James R., Stanakova, Alena, Sulem, Patrick, Theriault, Sebastien, Thorsteinsdottir, Unnur, Trompet, Stella, Varga, Tibor V., Edwards, Digna R. Velez, Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Yao, Jie, Young, Robin, Yu, Bing, Zhang, Weihua, Zhao, Jing-Hua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Blankenberg, Stefan, Bonnycastle, Lori L., Bork-Jensen, Jette, Brandslund, Ivan, Braund, Peter S., Burgess, Stephen, Cho, Kelly, Christensen, Cramer, Connell, John, de Mutsert, Renee, Dominiczak, Anna F., Dorr, Marcus, Eiriksdottir, Gudny, Farmaki, Aliki-Eleni, Gaziano, J. Michael, Grarup, Niels, Grove, Megan L., Hallmans, Göran, Hansen, Torben, Have, Christian T., Heiss, Gerardo, Jorgensen, Marit E., Jousilahti, Pekka, Kajantie, Eero, Kamat, Mihir, Karajamaki, AnneMari, Karpe, Fredrik, Koistinen, Heikki A., Kovesdy, Csaba P., Kuulasmaa, Kari, Laatikainen, Tiina, Lannfelt, Lars, Lee, I-Te, Lee, Wen-Jane, Linneberg, Allan, Martin, Lisa W., Moitry, Marie, Nadkarni, Girish, Neville, Matt J., Palmer, Colin N. A., Papanicolaou, George J., Pedersen, Oluf, Peters, James, Poulter, Neil, Rasheed, Asif, Rasmussen, Katrine L., Rayner, N. William, Magi, Reedik, Renström, Frida, Rettig, Rainer, Rossouw, Jacques, Schreiner, Pamela J., Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan, V, Sundstrom, Johan, Thorgeirsson, Gudmundur, Esko, Tonu, Trabetti, Elisabetta, Tsao, Philip S., Tuomi, Tiinamaija, Turner, Stephen T., Tzoulaki, Ioanna, Vaartjes, Ilonca, Vergnaud, Anne-Claire, Willer, Cristen J., Wilson, Peter W. F., Witte, Daniel R., Yonova-Doing, Ekaterina, Zhang, He, Aliya, Naheed, Almgren, Peter, Amouyel, Philippe, Asselbergs, Folkert W., Barnes, Michael R., Blakemore, Alexandra, I, Boehnke, Michael, Bots, Michiel L., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Conen, David, Correa, Adolfo, Smith, George Davey, de Boer, Rudolf A., Deary, Ian J., Dedoussis, George, Deloukas, Panos, Di Angelantonio, Emanuele, Elliott, Paul, Felix, Stephan B., Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Franks, Stephen, Frossard, Philippe, Gambaro, Giovanni, Gaunt, Tom R., Groop, Leif, Gudnason, Vilmundur, Harris, Tamara B., Hayward, Caroline, Hennig, Branwen J., Herzig, Karl-Heinz, Ingelsson, Erik, Tuomilehto, Jaakko, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kardia, Sharon L. R., Kee, Frank, Kooner, Jaspal S., Kooperberg, Charles, Launer, Lenore J., Lind, Lars, Loos, Ruth J. F., Majumder, Abdulla Al Shafi, Laakso, Markku, McCarthy, Mark, I, Melander, Olle, Mohlke, Karen L., Murray, Alison D., Nordestgaard, Borge Gronne, Orho-Melander, Marju, Packard, Chris J., Padmanabhan, Sandosh, Palmas, Walter, Polasek, Ozren, Porteous, David J., Prentice, Andrew M., Province, Michael A., Relton, Caroline L., Rice, Kenneth, Ridker, Paul M., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome, I, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sattar, Naveed, Sheu, Wayne H-H, Smith, Blair H., Soranzo, Nicole, Spector, Timothy D., Starr, John M., Sebert, Sylvain, Taylor, Kent D., Lakka, Timo A., Timpson, Nicholas J., Tobin, Martin D., van der Harst, Pim, van der Meer, Peter, Ramachandran, Vasan S., Verweij, Niek, Virtamo, Jarmo, Volker, Uwe, Weir, David R., Zeggini, Eleftheria, Charchar, Fadi J., Wareham, Nicholas J., Langenberg, Claudia, Tomaszewski, Maciej, Butterworth, Adam S., Caulfield, Mark J., Danesh, John, Edwards, Todd L., Holm, Hilma, Hung, Adriana M., Lindgren, Cecilia M., Liu, Chunyu, Manning, Alisa K., Morris, Andrew P., Morrison, Alanna C., O'Donnell, Christopher J., Psaty, Bruce M., Saleheen, Danish, Stefansson, Kari, Boerwinkle, Eric, Chasman, Daniel, I, Levy, Daniel, Newton-Cheh, Christopher, Munroe, Patricia B., Howson, Joanna M. M., Surendran, Praveen, Feofanova, Elena V., Lahrouchi, Najim, Ntalla, Ioanna, Karthikeyan, Savita, Cook, James, Chen, Lingyan, Mifsud, Borbala, Yao, Chen, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Thorleifsson, Gudmar, Liu, Dajiang J., Prins, Bram P., Stewart, Isobel D., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Auer, Paul L., Bielak, Lawrence F., Bis, Joshua C., Braithwaite, Vickie S., Brody, Jennifer A., Daw, E. Warwick, Warren, Helen R., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Fauman, Eric B., Fava, Cristiano, Ferreira, Teresa, Foley, Christopher N., Franceschini, Nora, Gao, He, Giannakopoulou, Olga, Giulianini, Franco, Gudbjartsson, Daniel F., Guo, Xiuqing, Harris, Sarah E., Havulinna, Aki S., Helgadottir, Anna, Huffman, Jennifer E., Hwang, Shih-Jen, Kanoni, Stavroula, Kontto, Jukka, Larson, Martin G., Li-Gao, Ruifang, Lindstrom, Jaana, Lotta, Luca A., Lu, Yingchang, Luan, Jian'an, Mahajan, Anubha, Malerba, Giovanni, Masca, Nicholas G. D., Mei, Hao, Menni, Cristina, Mook-Kanamori, Dennis O., Mosen-Ansorena, David, Muller-Nurasyid, Martina, Pare, Guillaume, Paul, Dirk S., Perola, Markus, Poveda, Alaitz, Rauramaa, Rainer, Richard, Melissa, Richardson, Tom G., Sepulveda, Nuno, Sim, Xueling, Smith, Albert, V, Smith, Jennifer A., Staley, James R., Stanakova, Alena, Sulem, Patrick, Theriault, Sebastien, Thorsteinsdottir, Unnur, Trompet, Stella, Varga, Tibor V., Edwards, Digna R. Velez, Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Yao, Jie, Young, Robin, Yu, Bing, Zhang, Weihua, Zhao, Jing-Hua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Blankenberg, Stefan, Bonnycastle, Lori L., Bork-Jensen, Jette, Brandslund, Ivan, Braund, Peter S., Burgess, Stephen, Cho, Kelly, Christensen, Cramer, Connell, John, de Mutsert, Renee, Dominiczak, Anna F., Dorr, Marcus, Eiriksdottir, Gudny, Farmaki, Aliki-Eleni, Gaziano, J. Michael, Grarup, Niels, Grove, Megan L., Hallmans, Göran, Hansen, Torben, Have, Christian T., Heiss, Gerardo, Jorgensen, Marit E., Jousilahti, Pekka, Kajantie, Eero, Kamat, Mihir, Karajamaki, AnneMari, Karpe, Fredrik, Koistinen, Heikki A., Kovesdy, Csaba P., Kuulasmaa, Kari, Laatikainen, Tiina, Lannfelt, Lars, Lee, I-Te, Lee, Wen-Jane, Linneberg, Allan, Martin, Lisa W., Moitry, Marie, Nadkarni, Girish, Neville, Matt J., Palmer, Colin N. A., Papanicolaou, George J., Pedersen, Oluf, Peters, James, Poulter, Neil, Rasheed, Asif, Rasmussen, Katrine L., Rayner, N. William, Magi, Reedik, Renström, Frida, Rettig, Rainer, Rossouw, Jacques, Schreiner, Pamela J., Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan, V, Sundstrom, Johan, Thorgeirsson, Gudmundur, Esko, Tonu, Trabetti, Elisabetta, Tsao, Philip S., Tuomi, Tiinamaija, Turner, Stephen T., Tzoulaki, Ioanna, Vaartjes, Ilonca, Vergnaud, Anne-Claire, Willer, Cristen J., Wilson, Peter W. F., Witte, Daniel R., Yonova-Doing, Ekaterina, Zhang, He, Aliya, Naheed, Almgren, Peter, Amouyel, Philippe, Asselbergs, Folkert W., Barnes, Michael R., Blakemore, Alexandra, I, Boehnke, Michael, Bots, Michiel L., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Conen, David, Correa, Adolfo, Smith, George Davey, de Boer, Rudolf A., Deary, Ian J., Dedoussis, George, Deloukas, Panos, Di Angelantonio, Emanuele, Elliott, Paul, Felix, Stephan B., Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Franks, Stephen, Frossard, Philippe, Gambaro, Giovanni, Gaunt, Tom R., Groop, Leif, Gudnason, Vilmundur, Harris, Tamara B., Hayward, Caroline, Hennig, Branwen J., Herzig, Karl-Heinz, Ingelsson, Erik, Tuomilehto, Jaakko, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kardia, Sharon L. R., Kee, Frank, Kooner, Jaspal S., Kooperberg, Charles, Launer, Lenore J., Lind, Lars, Loos, Ruth J. F., Majumder, Abdulla Al Shafi, Laakso, Markku, McCarthy, Mark, I, Melander, Olle, Mohlke, Karen L., Murray, Alison D., Nordestgaard, Borge Gronne, Orho-Melander, Marju, Packard, Chris J., Padmanabhan, Sandosh, Palmas, Walter, Polasek, Ozren, Porteous, David J., Prentice, Andrew M., Province, Michael A., Relton, Caroline L., Rice, Kenneth, Ridker, Paul M., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome, I, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sattar, Naveed, Sheu, Wayne H-H, Smith, Blair H., Soranzo, Nicole, Spector, Timothy D., Starr, John M., Sebert, Sylvain, Taylor, Kent D., Lakka, Timo A., Timpson, Nicholas J., Tobin, Martin D., van der Harst, Pim, van der Meer, Peter, Ramachandran, Vasan S., Verweij, Niek, Virtamo, Jarmo, Volker, Uwe, Weir, David R., Zeggini, Eleftheria, Charchar, Fadi J., Wareham, Nicholas J., Langenberg, Claudia, Tomaszewski, Maciej, Butterworth, Adam S., Caulfield, Mark J., Danesh, John, Edwards, Todd L., Holm, Hilma, Hung, Adriana M., Lindgren, Cecilia M., Liu, Chunyu, Manning, Alisa K., Morris, Andrew P., Morrison, Alanna C., O'Donnell, Christopher J., Psaty, Bruce M., Saleheen, Danish, Stefansson, Kari, Boerwinkle, Eric, Chasman, Daniel, I, Levy, Daniel, Newton-Cheh, Christopher, Munroe, Patricia B., and Howson, Joanna M. M.

Abstract

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets., Errata: Surendran, P., Feofanova, E.V., Lahrouchi, N. et al. Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics 53, 762 (2021). https://doi.org/10.1038/s41588-021-00832-z

Published
2020
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41. Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Author

Shelton, Jennifer MG, Corran, Patrick, Risley, Paul, Silva, Nilupa, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Craik, Rachel, Cornelius, Victoria, Hensmann, Meike, Molloy, Sile, Sepulveda, Nuno, Clark, Taane G, Band, Gavin, Clarke, Geraldine M, Spencer, Christopher CA, Kerasidou, Angeliki, Campino, Susana, Auburn, Sarah, Tall, Adama, Ly, Alioune Badara, Mercereau-Puijalon, Odile, Sakuntabhai, Anavaj, Djimdé, Abdoulaye, Maiga, Boubacar, Touré, Ousmane, Doumbo, Ogobara K, Dolo, Amagana, Troye-Blomberg, Marita, Mangano, Valentina D, Verra, Frederica, Modiano, David, Bougouma, Edith, Sirima, Sodiomon B, Ibrahim, Muntaser, Hussain, Ayman, Eid, Nahid, Elzein, Abier, Mohammed, Hiba, Elhassan, Ahmed, Elhassan, Ibrahim, Williams, Thomas N, Ndila, Carolyne, Macharia, Alexander, Marsh, Kevin, Manjurano, Alphaxard, Reyburn, Hugh, Lemnge, Martha, Ishengoma, Deus, Carter, Richard, Karunaweera, Nadira, Fernando, Deepika, Dewasurendra, Rajika, Drakeley, Christopher J, Riley, Eleanor M, Kwiatkowski, Dominic P, Rockett, Kirk A, MalariaGEN Consortium, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], London School of Hygiene and Tropical Medicine (LSHTM), National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency (MHRA), Nuffield Department of Population Health [Oxford], The Wellcome Trust Sanger Institute [Cambridge], Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Immunologie Moléculaire des Parasites, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Malaria Research and Training Center [Bamako, Mali], Université de Bamako, Stockholm University, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] (CNRFP), University of Khartoum, KEMRI-Wellcome Trust Research Programme (KWTRP), Tumaini University Makumira, National Institute for Medical Research [Tanzania] (NIMR), University of Edinburgh, University of Colombo [Sri Lanka], MalariaGEN is supported by the Wellcome Trust (077383/Z/05/Z) and by the Foundation for the National Institutes of Health (566) as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative. The Resource Centre for Genomic Epidemiology of Malaria is supported by the Wellcome Trust (090770/Z/09/Z). Support was also provided by the Medical Research Council (G0600718). DPK receives support from the Medical Research Council (G19/9). CCAS was supported by a Wellcome Trust Career Development Fellowship (097364/Z/11/Z). The Wellcome Trust also provides core awards to The Wellcome Trust Centre for Human Genetics (075491/Z/04, 090532/Z/09/Z) and the Wellcome Trust Sanger Institute (077012/Z/05/Z). MTB and BM received funding through the EU Network of Excellence EviMalar. VDM was funded by a Biomalpar (European Community’s Sixth Framework Programme) PhD fellowship. FV was funded by the Italian Malaria Network, sponsored by Compagnia di San Paolo, Turin, Italy. TNW is supported by a Senior Research Fellowship from the Wellcome Trust (091758/Z/10/Z). This study was conducted as part of the Joint Malaria Programme, a collaboration between the National Institute for Medical Research (NIMR), Kilimanjaro Christian Medical College (KCMC), the London School of Hygiene and Tropical Medicine (LSHTM) and the Centre for Medical Parasitology, University of Copenhagen (CMP) with funding from the UK Medical Research Council (GG9901439) and the Danish International Development Agency. CJD is supported by the Wellcome Trust (091924). RD is supported by the University of Colombo Research Grants 2011 (AP/3/2011/PG/15)., European Project: 26843,BIOMALPAR, University of Oxford, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)

Subjects
Male, Hemoglobin, Sickle, Antibodies, Protozoan, Sickle, MESH: Linear Models, MESH: Child, Child, HbAS, MESH: Infant, Newborn, Antibody, CD36, Genotype, Malaria, Sickle cell trait, Adolescent, Adult, Africa South of the Sahara, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Linear Models, Sri Lanka, Young Adult, Infectious Diseases, Parasitology, MESH: Infant, MESH: Young Adult, Protozoan, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Malaria, Antibodies, parasitic diseases, MESH: Antibodies, Protozoan, Hemoglobin, MESH: Africa South of the Sahara, Preschool, MESH: Sri Lanka, MESH: Adolescent, MESH: Humans, Research, MESH: Child, Preschool, MESH: Adult, Newborn, MESH: Hemoglobin, Sickle, MESH: Male, antibody, cd36, genotype, hbas, malaria, sickle cell trait, infectious diseases, parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract

Background Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologies. This study brings together samples and data collected from multiple sites across Africa and Asia to use standardized methods to look for consistent genetic effects on anti-malarial antibody levels. Methods Sera, DNA samples and clinical data were collected from 13,299 individuals from ten sites in Senegal, Mali, Burkina Faso, Sudan, Kenya, Tanzania, and Sri Lanka using standardized methods. DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques. Regression models were used to investigate the associations of clinical and genetic factors with antibody levels. Results Malaria infection increased levels of antibodies to malaria antigens and, as expected, stable predictors of anti-malarial antibody levels included age, seasonality, location, and ethnicity. Correlations between antibodies to blood-stage antigens AMA1, MSP1 and MSP2 were higher between themselves than with antibodies to the (NANP)4 epitope of the pre-erythrocytic circumsporozoite protein, while there was little or no correlation with total IgE levels. Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2. Conclusion Although the most significant finding with a consistent effect across sites was for sickle cell trait, its effect is likely to be via reducing a microscopically positive parasitaemia rather than directly on antibody levels. However, this study does demonstrate a framework for the feasibility of combining data from sites with heterogeneous malaria transmission levels across Africa and Asia with which to explore genetic effects on anti-malarial immunity. Electronic supplementary material The online version of this article (doi:10.1186/s12936-015-0833-x) contains supplementary material, which is available to authorized users.

Published
2015
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42. Additional file 3: of Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Author

Shelton, Jennifer, Corran, Patrick, Risley, Paul, Nilupa Silva, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Craik, Rachel, Cornelius, Victoria, Hensmann, Meike, Molloy, Sile, Sepulveda, Nuno, Taane Clark, Band, Gavin, Clarke, Geraldine, Spencer, Christopher, Kerasidou, Angeliki, Campino, Susana, Auburn, Sarah, Tall, Adama, Alioune Ly, Mercereau-Puijalon, Odile, Anavaj Sakuntabhai, Abdoulaye DjimdĂŠ, Boubacar Maiga, Ousmane TourĂŠ, Ogobara Doumbo, Amagana Dolo, Troye-Blomberg, Marita, Mangano, Valentina, Verra, Frederica, Modiano, David, Bougouma, Edith, Sodiomon Sirima, Muntaser Ibrahim, Hussain, Ayman, Eid, Nahid, Abier Elzein, Mohammed, Hiba, Elhassan, Ahmed, Elhassan, Ibrahim, Williams, Thomas, Ndila, Carolyne, Macharia, Alexander, Marsh, Kevin, Alphaxard Manjurano, Reyburn, Hugh, Lemnge, Martha, Deus Ishengoma, Carter, Richard, Karunaweera, Nadira, Fernando, Deepika, Rajika Dewasurendra, Drakeley, Christopher, Riley, Eleanor, Kwiatkowski, Dominic, and Rockett, Kirk

Abstract

Additional File LFST1A: Details of gene regions selected for genotyping and the SNP assay design details. This file contains a list of the genes from which SNPs were selected and typed for this study. Information is provided on the gene and its genomic location with respect to the Human Reference genome build GRCh37. Also provided is a table containing the assay design details for each SNP used in this study for the Agena Biosciences iPLEX genotyping platform. SNPs are grouped into multiplexes as assigned by the assay design software.

Published
2015
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43. Additional file 17: of Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Author

Shelton, Jennifer, Corran, Patrick, Risley, Paul, Nilupa Silva, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Craik, Rachel, Cornelius, Victoria, Hensmann, Meike, Molloy, Sile, Sepulveda, Nuno, Taane Clark, Band, Gavin, Clarke, Geraldine, Spencer, Christopher, Kerasidou, Angeliki, Campino, Susana, Auburn, Sarah, Tall, Adama, Alioune Ly, Mercereau-Puijalon, Odile, Anavaj Sakuntabhai, Abdoulaye DjimdĂŠ, Boubacar Maiga, Ousmane TourĂŠ, Ogobara Doumbo, Amagana Dolo, Troye-Blomberg, Marita, Mangano, Valentina, Verra, Frederica, Modiano, David, Bougouma, Edith, Sodiomon Sirima, Muntaser Ibrahim, Hussain, Ayman, Eid, Nahid, Abier Elzein, Mohammed, Hiba, Elhassan, Ahmed, Elhassan, Ibrahim, Williams, Thomas, Ndila, Carolyne, Macharia, Alexander, Marsh, Kevin, Alphaxard Manjurano, Reyburn, Hugh, Lemnge, Martha, Deus Ishengoma, Carter, Richard, Karunaweera, Nadira, Fernando, Deepika, Rajika Dewasurendra, Drakeley, Christopher, Riley, Eleanor, Kwiatkowski, Dominic, and Rockett, Kirk

Abstract

Additional Figure SF5: Plot for 178 SNPs with logged anti-malarial antibody levels. Plot for the P-values of the analyses of 178 SNPs with logged anti-malarial antibody levels Adjusted for age, gender, parasite density, village (>20), ethnicity (>20), sample month (>20) and study. This is an extension to that shown in the main text and is a reduced dataset as not all sites provided parasitaemia data.

Published
2015
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46. Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali

Author

Maiga, Bakary, Dolo, Amagana, Touré, Ousmane, Dara, Victor, Tapily, Amadou, Campino, Susana, Sepulveda, Nuno, Risley, Paul, Silva, Nilupa, Corran, Patrick, Rockett, Kirk A, Kwiatkowski, Dominic, MalariaGEN Consortium, Clark, Taane G, Troye-Blomberg, Marita, and Doumbo, Ogobara K

Subjects
Male, Adolescent, Cross-sectional study, Plasmodium falciparum, 030231 tropical medicine, Prevalence, lcsh:Medicine, Antibodies, Protozoan, Antigens, Protozoan, Single-nucleotide polymorphism, Mali, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Ethnicity, medicine, Humans, SNP, Genetic Predisposition to Disease, lcsh:Science, Child, Allele frequency, Disease Resistance, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, lcsh:R, Infant, Newborn, Infant, biology.organism_classification, medicine.disease, FCER1A, Immunity, Innate, Malaria, 3. Good health, Sympatry, Phenotype, Child, Preschool, Immunology, Cytokines, lcsh:Q, Female, Research Article
Abstract

Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmission rates, but Fulani individuals tend to show significantly higher spleen enlargement scores, lower parasite prevalence, and seem less affected by the disease than their Dogon neighbours. We have used genetic polymorphisms from malaria-associated genes to investigate associations with various malaria metrics between the Fulanai and Dogon groups. Two cross sectional surveys (transmission season 2006, dry season 2007) were performed. Healthy volunteers from the both ethnic groups (n=939) were recruited in a rural setting. In each survey, clinical (spleen enlargement, axillary temperature, weight) and parasitological data (malaria parasite densities and species) were collected, as well as blood samples. One hundred and sixty six SNPs were genotyped and 5 immunoassays (AMA1, CSP, MSP1, MSP2, total IgE) were performed on the DNA and serum samples respectively. The data confirm the reduced malaria susceptibility in the Fulani, with a higher level of the protective O-blood group, and increased circulating antibody levels to several malaria antigens (p

Published
2013

47. Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Author

Shelton, Jennifer M. G., Corran, Patrick, Risley, Paul, Silva, Nilupa, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Craik, Rachel, Cornelius, Victoria, Hensmann, Meike, Molloy, Sile, Sepulveda, Nuno, Clark, Taane G., Band, Gavin, Clarke, Geraldine M., Spencer, Christopher C. A., Kerasidou, Angeliki, Campino, Susana, Auburn, Sarah, Tall, Adama, Ly, Alioune Badara, Mercereau-Puijalon, Odile, Sakuntabhai, Anavaj, Djimde, Abdoulaye, Maiga, Boubacar, Toure, Ousmane, Doumbo, Ogobara K., Dolo, Amagana, Troye-Blomberg, Marita, Mangano, Valentina D., Verra, Frederica, Modiano, David, Bougouma, Edith, Sirima, Sodiomon B., Ibrahim, Muntaser, Hussain, Ayman, Eid, Nahid, Elzein, Abier, Mohammed, Hiba, Elhassan, Ahmed, Elhassan, Ibrahim, Williams, Thomas N., Ndila, Carolyne, Macharia, Alexander, Marsh, Kevin, Manjurano, Alphaxard, Reyburn, Hugh, Lemnge, Martha, Ishengoma, Deus, Carter, Richard, Karunaweera, Nadira, Fernando, Deepika, Dewasurendra, Rajika, Drakeley, Christopher J., Riley, Eleanor M., Kwiatkowski, Dominic P., Rockett, Kirk A., Shelton, Jennifer M. G., Corran, Patrick, Risley, Paul, Silva, Nilupa, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Craik, Rachel, Cornelius, Victoria, Hensmann, Meike, Molloy, Sile, Sepulveda, Nuno, Clark, Taane G., Band, Gavin, Clarke, Geraldine M., Spencer, Christopher C. A., Kerasidou, Angeliki, Campino, Susana, Auburn, Sarah, Tall, Adama, Ly, Alioune Badara, Mercereau-Puijalon, Odile, Sakuntabhai, Anavaj, Djimde, Abdoulaye, Maiga, Boubacar, Toure, Ousmane, Doumbo, Ogobara K., Dolo, Amagana, Troye-Blomberg, Marita, Mangano, Valentina D., Verra, Frederica, Modiano, David, Bougouma, Edith, Sirima, Sodiomon B., Ibrahim, Muntaser, Hussain, Ayman, Eid, Nahid, Elzein, Abier, Mohammed, Hiba, Elhassan, Ahmed, Elhassan, Ibrahim, Williams, Thomas N., Ndila, Carolyne, Macharia, Alexander, Marsh, Kevin, Manjurano, Alphaxard, Reyburn, Hugh, Lemnge, Martha, Ishengoma, Deus, Carter, Richard, Karunaweera, Nadira, Fernando, Deepika, Dewasurendra, Rajika, Drakeley, Christopher J., Riley, Eleanor M., Kwiatkowski, Dominic P., and Rockett, Kirk A.

Abstract

Background: Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologies. This study brings together samples and data collected from multiple sites across Africa and Asia to use standardized methods to look for consistent genetic effects on anti-malarial antibody levels. Methods: Sera, DNA samples and clinical data were collected from 13,299 individuals from ten sites in Senegal, Mali, Burkina Faso, Sudan, Kenya, Tanzania, and Sri Lanka using standardized methods. DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP) 4] plus total IgE were measured by ELISA techniques. Regression models were used to investigate the associations of clinical and genetic factors with antibody levels. Results: Malaria infection increased levels of antibodies to malaria antigens and, as expected, stable predictors of anti-malarial antibody levels included age, seasonality, location, and ethnicity. Correlations between antibodies to blood-stage antigens AMA1, MSP1 and MSP2 were higher between themselves than with antibodies to the (NANP)(4) epitope of the pre-erythrocytic circumsporozoite protein, while there was little or no correlation with total IgE levels. Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2. Conclusion: Although the most significant finding with a consistent effect across sites was for sickle cell trait, its effect is likely to be via reducing a microscopically positive parasitaemia rather than directly on antibody levels. However, this study does demons

Published
2015
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48. Novel Insights Into the Protective Role of Hemoglobin S and C AgainstPlasmodium falciparumParasitemia

Author

Mangano, Valentina D., primary, Kabore, Youssouf, additional, Bougouma, Edith C., additional, Verra, Federica, additional, Sepulveda, Nuno, additional, Bisseye, Cyrille, additional, Santolamazza, Federica, additional, Avellino, Pamela, additional, Tiono, Alfred B., additional, Diarra, Amidou, additional, Nebie, Issa, additional, Rockett, Kirk A., additional, Sirima, Sodiomon B., additional, and Modiano, David, additional

Published
2015
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49. Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

Author

Maiga, Bakary, Dolo, Amagana, Campino, Susana, Sepulveda, Nuno, Corran, Patrick, Rockett, Kirk A., Troye-Blomberg, Marita, Doumbo, Ogobara K., Clark, Taane G., Maiga, Bakary, Dolo, Amagana, Campino, Susana, Sepulveda, Nuno, Corran, Patrick, Rockett, Kirk A., Troye-Blomberg, Marita, Doumbo, Ogobara K., and Clark, Taane G.

Abstract

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with protection from severe malaria, and potentially uncomplicated malaria phenotypes. It has been documented that G6PD deficiency in sub-Saharan Africa is due to the 202A/376G G6PD A-allele, and association studies have used genotyping as a convenient technique for epidemiological studies. However, recent studies have shown discrepancies in G6PD202/376 associations with severe malaria. There is evidence to suggest that other G6PD deficiency alleles may be common in some regions of West Africa, and that allelic heterogeneity could explain these discrepancies. Methods: A cross-sectional epidemiological study of malaria susceptibility was conducted during 2006 and 2007 in the Sahel meso-endemic malaria zone of Mali. The study included Dogon (n = 375) and Fulani (n = 337) sympatric ethnic groups, where the latter group is characterized by lower susceptibility to Plasmodium falciparum malaria. Fifty-three G6PD polymorphisms, including 202/376, were genotyped across the 712 samples. Evidence of association of these G6PD polymorphisms and mild malaria was assessed in both ethnic groups using genotypic and haplotypic statistical tests. Results: It was confirmed that the Fulani are less susceptible to malaria, and the 202A mutation is rare in this group (< 1% versus Dogon 7.9%). The Betica-Selma 968C/376G (similar to 11% enzymatic activity) was more common in Fulani (6.1% vs Dogon 0.0%). There are differences in haplotype frequencies between Dogon and Fulani, and association analysis did not reveal strong evidence of protective G6PD genetic effects against uncomplicated malaria in both ethnic groups and gender. However, there was some evidence of increased risk of mild malaria in Dogon with the 202A mutation, attaining borderline statistical significance in females. The rs915942 polymorphism was found to be associated with asymptomatic malaria in Dogon females, and the rs61042368 polymorphism w, AuthorCount:9

Published
2014
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