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514 results on '"Sepulveda, Antonia R."'

2. Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists in Collaboration With the Association for Molecular Pathology and Fight Colorectal Cancer

Author

Bartley, Angela N., Mills, Anne M., Konnick, Eric, Overman, Michael, Ventura, Christina B., Souter, Lesley, Colasacco, Carol, Stadler, Zsofia K., Kerr, Sarah, Howitt, Brooke E., Hampel, Heather, Adams, Sarah F., Johnson, Wenora, Magi-Galluzzi, Cristina, Sepulveda, Antonia R., and Broaddus, Russell R.

Subjects
Practice guidelines (Medicine) -- Evaluation, Colorectal cancer -- Care and treatment, Immunotherapy -- Testing, DNA mismatch repair -- Testing, Microsatellite instability -- Testing, Health
Abstract

* Context.--The US Food and Drug Administration (FDA) approved immune checkpoint inhibitor therapy for patients with advanced solid tumors that have DNA mismatch repair defects or high levels of microsatellite instability; however, the FDA provided no guidance on which specific clinical assays should be used to determine mismatch repair status. Objective.--To develop an evidence-based guideline to identify the optimal clinical laboratory test to identify defects in DNA mismatch repair in patients with solid tumor malignancies who are being considered for immune checkpoint inhibitor therapy. Design.--The College of American Pathologists convened an expert panel to perform a systematic review of the literature and develop recommendations. Using the National Academy of Medicine-endorsed Grading of Recommendations Assessment, Development and Evaluation approach, the recommendations were derived from available evidence, strength of that evidence, open comment feedback, and expert panel consensus. Mismatch repair immunohistochemistry, microsatellite instability derived from both polymerase chain reaction and next-generation sequencing, and tumor mutation burden derived from large panel next-generation sequencing were within scope. Results.--Six recommendations and 3 good practice statements were developed. More evidence and evidence of higher quality were identified for colorectal cancer and other cancers of the gastrointestinal (GI) tract than for cancers arising outside the GI tract. Conclusions.--An optimal assay depends on cancer type. For most cancer types outside of the GI tract and the endometrium, there was insufficient published evidence to recommend a specific clinical assay. Absent published evidence, immunohistochemistry is an acceptable approach readily available in most clinical laboratories. doi: 10.5858/arpa.2021-0632-CP, Clinical laboratory assays for detection of high levels of tumor microsatellite instability (MSI-High) or loss of DNA mismatch repair (MMR) protein expression by immunohistochemistry (IHC) are familiar to many pathologists [...]

Published
2022
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4. IFN-[gamma]R/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease

Author

Lu, Caisheng, Ma, Huihui, Song, Liangsong, Wang, Hui, Wang, Lily, Li, Shirong, Lagana, Stephen M., Sepulveda, Antonia R., Hoebe, Kasper, Pan, Samuel S., Yang, Yong-Guang, Lentzsch, Suzanne, and Mapara, Markus Y.

Subjects
Interferon -- Health aspects, Immunological research, STAT1 -- Health aspects, Graft versus host reaction -- Development and progression, Cellular signal transduction -- Research, Antigen presenting cells -- Health aspects, Hematopoietic system -- Health aspects, Health care industry
Abstract

The absence of IFN-[gamma] receptor (IFN-[gamma]R) or STAT1 signaling in donor cells has been shown to result in reduced induction of acute graft-versus-host disease (GVHD). In this study, we unexpectedly observed increased activation and expansion of donor lymphocytes in both lymphohematopoietic organs and GVHD target tissues of IFN-[gamma]R/STAT1-deficient recipient mice, leading to rapid mortality following the induction of GVHD. LPS-matured, BM-derived [Ifngr1.sup.-/-] [Stat1.sup.-/-] DCs (BMDCs) were more potent allogeneic stimulators and expressed increased levels of MHC II and costimulatory molecules. Similar effects were observed in human antigen-presenting cells (APCs) with knockdown of Stat1 by CRISPR/Cas9 and treatment with a JAK1/2 inhibitor. Furthermore, we demonstrated that the absence of IFN-[gamma]R/STAT1 signaling in hematopoietic APCs impaired the presentation of exogenous antigens, while promoting the presentation of endogenous antigens. Thus, the indirect presentation of host antigens to donor lymphocytes was defective in IFN-^R/STAT1-deficient, donor-derived APCs in fully donor chimeric mice. The differential effects of IFN-[gamma]R/STAT1 signaling on endogenous and exogenous antigen presentation could provide further insight into the roles of the IFN-[gamma]/STAT1 signaling pathway in the pathogenesis of GVHD, organ rejection, and autoimmune diseases., Introduction IFN-[gamma] is a pleiotropic cytokine with a central role in host defense and immunopathology and is involved in both innate and adaptive immunity (1, 2). IFN-[gamma] is the only [...]

Published
2023
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5. List of contributors

Author

Aftimos, Philippe, primary, Al-Turkmani, M. Rabie, additional, Azim, Hatem A., additional, Bastacky, Sheldon I., additional, Beenhouwer, David O., additional, Behari, Jaideep, additional, Berdasco, María, additional, Biggs, Joseph R., additional, Brandão, Mariana, additional, Campbell, Sheldon, additional, Chan, Wai-Yee, additional, Coleman, William B., additional, Corsi Romanelli, Massimiliano M., additional, Couch, Robin D., additional, Davis, Justin B., additional, Deharvengt, Sophie J., additional, Del Portillo, Armando J., additional, Espina, Virginia, additional, Esteller, Manel, additional, Farver, Carol F., additional, Feldman, Michael D., additional, Fink, Susan L., additional, Flanagan, Margaret, additional, Fredolini, Claudia, additional, Funkhouser, William K., additional, Futschik, Matthias E., additional, Galliera, Emanuela, additional, Gotlieb, Avrum I., additional, Hevner, Robert F., additional, Highsmith, W. Edward, additional, Keene, Christopher Dirk, additional, Key, Nigel S., additional, Koellner, Christine M., additional, Lefferts, Joel A., additional, Lemasters, John J., additional, Lerch, Markus M., additional, Liotta, Lance A., additional, Liu, Youhua, additional, Lu, Karen H., additional, Lukacs, Nicholas W., additional, Ma, Alice D., additional, Martin, Karlyn, additional, Mayerle, Julia, additional, Mensink, Kara A., additional, Mok, Samuel C., additional, Monga, Satdarshan P.S., additional, Montine, Thomas J., additional, Moore, Jason H., additional, Morkel, Markus, additional, Munger, Karl, additional, Nagymanyoki, Zoltan, additional, Nerenz, Robert D., additional, Pang, Alan L.-Y., additional, Petricoin, Emanuel, additional, Ptaschinski, Catherine, additional, Schäfer, Reinhold, additional, Sendler, Matthias, additional, Sepulveda, Antonia R., additional, Sers, Christine, additional, Silverman, Lawrence M., additional, Sonnen, Joshua A., additional, Sotiriou, Christos, additional, Tan, Roderick J., additional, Tsongalis, Gregory J., additional, Wessagowit, Vesarat, additional, Williams, Eli S., additional, Wong, Kwong-Kwok, additional, Zander, Dani S., additional, Zhang, Dong-Er, additional, and Zhou, Weidong, additional

Published
2020
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9. Colorectal Cancer

Author

Sepulveda, Antonia R., Ma, Deqin, Behling, Kathryn C., Fernandes, Helen, and Leonard, Debra G.B., editor

Published
2016
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10. HER2 Heterogeneity in Gastroesophageal Cancer Detected by Testing Biopsy and Resection Specimens

Author

Fazlollahi, Ladan, Remotti, Helen E., Iuga, Alina, Yang, Hui-Min, Lagana, Stephen M., and Sepulveda, Antonia R.

Subjects
Stomach cancer -- Genetic aspects -- Diagnosis -- Research, Immunohistochemistry -- Usage -- Research, Esophageal cancer -- Genetic aspects -- Diagnosis -- Research, Health
Abstract

Context.--In advanced gastric, esophageal, and gastroesophageal junction adenocarcinomas (GE-GEJ-AC) that overexpress ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2), anti-HER2 monoclonal antibody therapy confers survival benefit. To select patients for treatment, HER2 expression and gene amplification are evaluated by immunohistochemistry (IHC) and in situ hybridization. Objective.--To determine whether GE-GEJ-AC tested for HER2 on biopsy specimens of a primary tumor show different IHC scores and/or HER2 amplification by in situ hybridization in matched resection specimens, potentially changing therapy eligibility. Design.--Immunohistochemistry and silver in situ hybridization were performed in biopsy and/or resection specimens from 100 patients. HER2 testing was performed in matched resection and biopsy specimens of 15 cases to determine whether GE-GEJ-AC with IHC scores of 0, 1+, and 2+ in biopsy and resection specimens had different IHC and silver in situ hybridization results. Results.--The IHC 3+ cases showed HER2 amplification in 4 of 5 cases (80%), and IHC scores of 0, 1+, and 2+ showed 3.5%, 14.3%, and 23.5% HER2 amplification by silver in situ hybridization. Among the 15 paired biopsy and resection specimens, 9 (60%) had at least pT2 stage GE-GEJ-AC with HER2 IHC scores of 0, 1+, or 2+ in the biopsy, and 2 of those 9 cases (22%) had IHC 3+ and HER2 amplification by silver in situ hybridization on the resection specimen. Conclusions.--Our data suggest that HER2 testing should be repeated on resection specimens of GE-GEJ-AC with HER2 IHC scores of negative (0 and 1+) or equivocal (2+) and in situ hybridization amplification negative biopsy specimen results to evaluate for HER2 heterogeneity when patients are being considered for anti-HER2 therapy. doi: 10.5858/arpa.2017-0039-OA, Gastric adenocarcinoma is the most frequent malignancy arising in the stomach, and nearly 1 million new cases were estimated to have occurred in 2012, representing the fifth most common malignancy [...]

Published
2018
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15. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

Author

Alvarez, Mariano J., Subramaniam, Prem S., Tang, Laura H., Grunn, Adina, Aburi, Mahalaxmi, Rieckhof, Gabrielle, Komissarova, Elena V., Hagan, Elizabeth A., Bodei, Lisa, Clemons, Paul A., Dela Cruz, Filemon S., Dhall, Deepti, Diolaiti, Daniel, Fraker, Douglas A., Ghavami, Afshin, Kaemmerer, Daniel, Karan, Charles, Kidd, Mark, Kim, Kyoung M., Kim, Hee C., Kunju, Lakshmi P., Langel, Ülo, Li, Zhong, Lee, Jeeyun, Li, Hai, LiVolsi, Virginia, Pfragner, Roswitha, Rainey, Allison R., Realubit, Ronald B., Remotti, Helen, Regberg, Jakob, Roses, Robert, Rustgi, Anil, Sepulveda, Antonia R., Serra, Stefano, Shi, Chanjuan, Yuan, Xiaopu, Barberis, Massimo, Bergamaschi, Roberto, Chinnaiyan, Arul M., Detre, Tony, Ezzat, Shereen, Frilling, Andrea, Hommann, Merten, Jaeger, Dirk, Kim, Michelle K., Knudsen, Beatrice S., Kung, Andrew L., Leahy, Emer, Metz, David C., Milsom, Jeffrey W., Park, Young S., Reidy-Lagunes, Diane, Schreiber, Stuart, Washington, Kay, Wiedenmann, Bertram, Modlin, Irvin, and Califano, Andrea

Published
2018
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17. Supplementary figure 1 from CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma

Author

Fang, Hsin-Yu, primary, Münch, Natasha Stephens, primary, Schottelius, Margret, primary, Ingermann, Jonas, primary, Liu, Haibo, primary, Schauer, Michael, primary, Stangl, Stefan, primary, Multhoff, Gabriele, primary, Steiger, Katja, primary, Gerngroß, Carlos, primary, Jesinghaus, Moritz, primary, Weichert, Wilko, primary, Kühl, Anja A., primary, Sepulveda, Antonia R., primary, Wester, Hans-Jürgen, primary, Wang, Timothy C., primary, and Quante, Michael, primary

Published
2023
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18. Supplementary figure 2 from CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma

Author

Fang, Hsin-Yu, primary, Münch, Natasha Stephens, primary, Schottelius, Margret, primary, Ingermann, Jonas, primary, Liu, Haibo, primary, Schauer, Michael, primary, Stangl, Stefan, primary, Multhoff, Gabriele, primary, Steiger, Katja, primary, Gerngroß, Carlos, primary, Jesinghaus, Moritz, primary, Weichert, Wilko, primary, Kühl, Anja A., primary, Sepulveda, Antonia R., primary, Wester, Hans-Jürgen, primary, Wang, Timothy C., primary, and Quante, Michael, primary

Published
2023
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19. Data from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Author

Amaravadi, Ravi K., primary, Hamilton, Kathryn E., primary, Ma, Xiaohong, primary, Piao, Shengfu, primary, Portillo, Armando Del, primary, Nathanson, Katherine L., primary, Carlino, Matteo S., primary, Long, Georgina V., primary, Puzanov, Igor, primary, Xu, Xiaowei, primary, Morrissette, Jennifer J.D., primary, Tsai, Kenneth Y., primary, Flaherty, Keith T., primary, Sosman, Jeffrey A., primary, Goodman, Grant R., primary, McArthur, Grant A., primary, Rustgi, Anil K., primary, Metz, David C., primary, Schuchter, Lynn M., primary, Chapman, Paul B., primary, and Sepulveda, Antonia R., primary

Published
2023
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20. Supplemental Figure 1 from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Author

Amaravadi, Ravi K., primary, Hamilton, Kathryn E., primary, Ma, Xiaohong, primary, Piao, Shengfu, primary, Portillo, Armando Del, primary, Nathanson, Katherine L., primary, Carlino, Matteo S., primary, Long, Georgina V., primary, Puzanov, Igor, primary, Xu, Xiaowei, primary, Morrissette, Jennifer J.D., primary, Tsai, Kenneth Y., primary, Flaherty, Keith T., primary, Sosman, Jeffrey A., primary, Goodman, Grant R., primary, McArthur, Grant A., primary, Rustgi, Anil K., primary, Metz, David C., primary, Schuchter, Lynn M., primary, Chapman, Paul B., primary, and Sepulveda, Antonia R., primary

Published
2023
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21. Supplementary figure 3 from CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma

Author

Fang, Hsin-Yu, primary, Münch, Natasha Stephens, primary, Schottelius, Margret, primary, Ingermann, Jonas, primary, Liu, Haibo, primary, Schauer, Michael, primary, Stangl, Stefan, primary, Multhoff, Gabriele, primary, Steiger, Katja, primary, Gerngroß, Carlos, primary, Jesinghaus, Moritz, primary, Weichert, Wilko, primary, Kühl, Anja A., primary, Sepulveda, Antonia R., primary, Wester, Hans-Jürgen, primary, Wang, Timothy C., primary, and Quante, Michael, primary

Published
2023
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22. Supplemental Methods from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Author

Amaravadi, Ravi K., primary, Hamilton, Kathryn E., primary, Ma, Xiaohong, primary, Piao, Shengfu, primary, Portillo, Armando Del, primary, Nathanson, Katherine L., primary, Carlino, Matteo S., primary, Long, Georgina V., primary, Puzanov, Igor, primary, Xu, Xiaowei, primary, Morrissette, Jennifer J.D., primary, Tsai, Kenneth Y., primary, Flaherty, Keith T., primary, Sosman, Jeffrey A., primary, Goodman, Grant R., primary, McArthur, Grant A., primary, Rustgi, Anil K., primary, Metz, David C., primary, Schuchter, Lynn M., primary, Chapman, Paul B., primary, and Sepulveda, Antonia R., primary

Published
2023
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43. List of Contributors

Author

Aftimos, Philippe, primary, Azim, Hatem A., additional, Bastacky, Sheldon I., additional, Beenhouwer, David O., additional, Behari, Jaideep, additional, Biggs, Joseph R., additional, Campbell, Sheldon, additional, Chan, Wai-Yee, additional, Coleman, William B., additional, Corsi Romanelli, Massimiliano M., additional, Couch, Robin D., additional, Davis, Justin B., additional, Deharvengt, Sophie J., additional, Del Portillo, Armando J., additional, Espina, Virginia, additional, Esteller, Manel, additional, Farver, Carol F., additional, Feldman, Michael D., additional, Fink, Susan L., additional, Flanagan, Margaret, additional, Fredolini, Claudia, additional, Funkhouser, William K., additional, Futschik, Matthias E., additional, Galliera, Emanuela, additional, Gotlieb, Avrum I., additional, Hevner, Robert F., additional, Edward Highsmith, W., additional, Keene, Christopher Dirk, additional, Key, Nigel S., additional, Koellner, Christine M., additional, Lemasters, John J., additional, Lerch, Markus M., additional, Liotta, Lance A., additional, Liu, Youhua, additional, Lu, Karen H., additional, Lukacs, Nicholas W., additional, Ma, Alice D., additional, Martin, Karlyn, additional, Mayerle, Julia, additional, Mensink, Kara A., additional, Mok, Samuel C., additional, Monga, Satdarshan P.S., additional, Montine, Thomas J., additional, Moore, Jason H., additional, Morkel, Markus, additional, Munger, Karl, additional, Nagymanyoki, Zoltan, additional, Nerenz, Robert D., additional, Pang, Alan L.-Y., additional, Petricoin, Emanuel, additional, Ptaschinski, Catherine, additional, Schäfer, Reinhold, additional, Sendler, Matthias, additional, Sepulveda, Antonia R., additional, Sers, Christine, additional, Silverman, Lawrence M., additional, Sonnen, Joshua A., additional, Sotiriou, Christos, additional, Tan, Roderick J., additional, Tsongalis, Gregory J., additional, Wessagowit, Vesarat, additional, Williams, Eli S., additional, Wong, Kwong-Kwok, additional, Zander, Dani S., additional, Zhang, Dong-Er, additional, and Zhou, Weidong, additional

Published
2018
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44. IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease

Author

Lu, Caisheng, primary, Ma, Huihui, additional, Song, Liangsong, additional, Wang, Hui, additional, Wang, Lily, additional, Li, Shirong, additional, Lagana, Stephen M., additional, Sepulveda, Antonia R., additional, Hoebe, Kasper, additional, Pan, Samuel S., additional, Yang, Yong-Guang, additional, Lentzsch, Suzanne, additional, and Mapara, Markus Y., additional

Published
2023
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47. Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus

Author

Jiang, Ming, Li, Haiyan, Zhang, Yongchun, Yang, Ying, Lu, Rong, Liu, Kuancan, Lin, Sijie, Lan, Xiaopeng, Wang, Haikun, Wu, Han, Zhu, Jian, Zhou, Zhongren, Xu, Jianming, Lee, Dong-Kee, Zhang, Lanjing, Lee, Yuan-Cho, Yuan, Jingsong, Abrams, Julian A., Wang, Timothy C., Sepulveda, Antonia R., Wu, Qi, Chen, Huaiyong, Sun, Xin, She, Junjun, Chen, Xiaoxin, and Que, Jianwen

Published
2017
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48. Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology

Author

Sepulveda, Antonia R., Hamilton, Stanley R., Allegra, Carmen J., Grody, Wayne, Cushman-Vokoun, Allison M., Funkhouser, William K., Kopetz, Scott E., Lieu, Christopher, Lindor, Noralane M., Minsky, Bruce D., Monzon, Federico A., Sargent, Daniel J., Singh, Veena M., Willis, Joseph, Clark, Jennifer, Colasacco, Carol, Rumble, R. Bryan, Temple-Smolkin, Robyn, Ventura, Christina B., and Nowak, Jan A.

Published
2017
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